EPA Listed Wastes Table 1: Maximum Concentration of Contaminants For
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Methyl Ethyl Ketone (2-Butanone)
Methyl Ethyl Ketone (2-Butanone) 78-93-3 Hazard Summary Methyl ethyl ketone is used as a solvent. Acute (short-term) inhalation exposure to methyl ethyl ketone in humans results in irritation to the eyes, nose, and throat. Limited information is available on the chronic (long-term) effects of methyl ethyl ketone in humans. Chronic inhalation studies in animals have reported slight neurological, liver, kidney, and respiratory effects. No information is available on the developmental, reproductive, or carcinogenic effects of methyl ethyl ketone in humans. Developmental effects, including decreased fetal weight and fetal malformations, have been reported in mice and rats exposed to methyl ethyl ketone via inhalation and ingestion. EPA has classified methyl ethyl ketone as a Group D, not classifiable as to human carcinogenicity. Please Note: The main sources of information for this fact sheet are EPA's Health Effects Assessment for Methyl Ethyl Ketone (1) and EPA's Integrated Risk Information System (IRIS) (6), which contains information on inhalation chronic toxicity of methyl ethyl ketone and the RfC and oral chronic toxicity and the RfD. Uses The primary use of methyl ethyl ketone is as a solvent in processes involving gums, resins, cellulose acetate, and cellulose nitrate. (1) Methyl ethyl ketone is also used in the synthetic rubber industry, in the production of paraffin wax, and in household products such as lacquer and varnishes, paint remover, and glues. (1) Sources and Potential Exposure Methyl ethyl ketone has been detected in both indoor and outdoor air. Methyl ethyl ketone can be produced in outdoor air by the photooxidation of certain air pollutants, such as butane and other hydrocarbons. -
Methyl Isopropyl Ketone Safety Data Sheet According to Federal Register / Vol
Methyl isopropyl ketone Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 05/25/2015 Version: 1.0 SECTION 1: Identification 1.1. Identification Product form : Substance Substance name : Methyl isopropyl ketone CAS-No. : 563-80-4 Product code : (US) W1814 Formula : C5H10O Synonyms : 3-Methylbutane-2-one / Isopropyl methyl ketone / Methyl-2-butanone, 3- / 2-Acetylpropane / 3- Methylbutanone-2 / 3-Methylbutanone / 3-Methylbutan-2-one / 3-Methyl-2-butanone / 2- Butanone, 3-methyl- / Butan-2-one, 3-methyl- 1.2. Recommended use and restrictions on use No additional information available 1.3. S upplie r Synerzine 5340 Hwy 42 S Ellenwood, Georgia 30294 - USA T 404-524-6744 - F 404-577-1651 [email protected] - www.synerzine.com 1.4. Emergency telephone number Emergency number : Infotrac 1-800-535-5053 (Contract# 102471) Dial +1-352-323-3500 when outside the US SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mi xt ure GHS -US classification Flammable liquids Category H225 Highly flammable liquid and vapour 2 Specific target organ toxicity H336 May cause drowsiness or dizziness (single exposure) Category 3 Hazardous to the aquatic H402 Harmful to aquatic life environment - Acute Hazard Category 3 Full text of H statements : see section 16 2.2. GHS Label elements, including precautionary statements GHS-US labeling Hazard pictograms (GHS-US) : Signal word (GHS-US) : Danger Hazard statements (GHS-US) : H225 - Highly flammable liquid and vapour H336 - May cause drowsiness or dizziness H402 - Harmful to aquatic life Precautionary statements (GHS-US) : P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. -
Nitric Oxide in Health and Disease of the Nervous System H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3
Molecular Psychiatry (1997) 2, 300–310 1997 Stockton Press All rights reserved 1359–4184/97 $12.00 PROGRESS Nitric oxide in health and disease of the nervous system H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3 Departments of 1Neurology; 3Neuroscience; 4Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (NOS) isoforms (neuronal, endothelial and immunologic NOS). Endothelial NOS and neuronal NOS are constitutively expressed and acti- vated by elevated intracellular calcium, whereas immunologic NOS is inducible with new RNA and protein synthesis upon immune stimulation. Neuronal NOS can be transcriptionally induced under conditions such as neuronal development and injury. NO may play a role not only in physiologic neuronal functions such as neurotransmitter release, neural development, regeneration, synaptic plasticity and regulation of gene expression but also in a variety of neurological disorders in which excessive production of NO leads to neural injury. Keywords: nitric oxide synthase; endothelium-derived relaxing factor; neurotransmission; neurotoxic- ity; neurological diseases Nitric oxide is probably the smallest and most versatile NO synthases isoforms and regulation of NO bioactive molecule identified. Convergence of multi- generation disciplinary efforts in the field of immunology, cardio- vascular pharmacology, chemistry, toxicology and neu- NO is formed by the enzymatic conversion of the guan- robiology led to the revolutionary novel concept of NO idino nitrogen of l-arginine by NO synthase (NOS). -
Toxicological Profile for 2-Butanone Released for Public Comment in May 2019
Toxicological Profile for 2-Butanone October 2020 2-BUTANONE ii DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. 2-BUTANONE iii FOREWORD This toxicological profile is prepared in accordance with guidelines* developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. The adequacy of information to determine a substance's -
References on Use of CO2 for Medical
Some References on the Use of CO2 for Medical Entomology Survey Becker N et al. Comparison of carbon dioxide, octenol and a host-odour as mosquito attractants in the Upper Rhine Valley, Germany. Med Vet Entomol 1995;9:377-80. Abstract: Field studies were conducted in the Upper Rhine Valley to determine the responses of mosquitoes to CDC traps baited with either CO2, octenol, light or paired combinations of these. Among eight mosquito species caught, the attractant effect on trap catches was studied in the four most abundant: Aedes vexans, Ae. rossicus, Ae. cinereus and Culex pipiens. Traps baited only with light or octenol caught few mosquitoes, whereas many were caught by traps baited with CO2 alone or in combination with either of the other candidate attractants. CO2 baited traps, with or without light, caught the most Aedes. The combination of CO2 and octenol attracted most Cx pipiens, but this apparent synergy was not significant. Using a caged hamster compared to CO2 as bait in a CDC light-trap with only intermittent fan suction, the hamster attracted less mosquitoes than CO2 emitted at a rate of 225 g/h on days 1 and 2, whereas on days 3 and 4 the smell from the hamster's cage became significantly more attractive than this rate of CO2 for all species of mosquitoes. Canyon DV, Hii JL. Efficacy of carbon dioxide, 1-octen-3-ol, and lactic acid in modified Fay- Prince traps as compared to man-landing catch of Aedes aegypti. J Am Mosq Control Assoc 1997;13:66-70. Abstract: The attractants 1-octen-3-ol and lactic acid significantly decreased catches of Aedes aegypti in Townsville, Australia, by 50% in a controlled laboratory environment and by 100% in the field when compared to carbon dioxide baited bidirectional Fay-Prince trap catches. -
Dose–Response Assay for Synthetic Mosquito (Diptera: Culicidae) Attractant Using a High-Throughput Screening System
insects Article Dose–Response Assay for Synthetic Mosquito (Diptera: Culicidae) Attractant Using a High-Throughput Screening System Dae-Yun Kim 1, Theerachart Leepasert 2, Michael J. Bangs 1 and Theeraphap Chareonviriyaphap 1,* 1 Department of Entomology, Faculty of Agriculture, Kasetsart Univeristy, Bangkok 10900, Thailand; [email protected] (D.-Y.K.); [email protected] (M.J.B.) 2 Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand; [email protected] * Correspondence: [email protected] Simple Summary: Entomological surveillance is important to evaluate vector management inter- ventions. However, collecting adult mosquitoes using direct human bait is controversial and often discouraged because of potential infection risk. Alternatively, active and passive trapping methods are available. Female mosquitoes detect human host cues such as body heat, carbon dioxide, and other volatile body emanations using olfactory sensilla to direct movement to a host. Attractive chemical lures have been identified and evaluated using a variety of olfactometric methods to in- crease trap production and efficiency. In this study, we evaluated a simple olfactometer without need of airflow. To ‘optimize’ a commercial mosquito attractant, 10 different doses of product, the TM Biogents-lure (BG-lure ), were compared. Results showed dose-dependent responses with 0.005 g with the highest attraction for Aedes aegypti, while doses of 0.2 g and above produced a repellent Citation: Kim, D.-Y.; Leepasert, T.; response. There was no significantly different response behavior between permethrin-susceptible Bangs, M.J.; Chareonviriyaphap, T. and -resistant Ae. aegypti. Culex quinquefasciatus showed significantly different responses compared Dose–Response Assay for Synthetic to Ae. -
Past Use of Chlordane, Dieldrin, And
The Hazard Evaluation and Emergency Response Office (HEER Office) is part of the Hawai‘i Department of Health (HDOH) Environmental Health Administration, whose mission is to protect human health and the environment. The HEER Office provides leadership, support, and partnership in preventing, planning for, responding to, and enforcing environmental laws relating to releases or threats of releases of hazardous substances. Past Use of Chlordane, Dieldrin, and other Organochlorine Pesticides for Termite Control in Hawai‘i: Safe Management Practices around Treated Foundations or during Building Demolition This fact sheet provides building owners, demolition and construction contractors, developers, realtors, and others with an overview of the potential environmental concerns associated with the past use of organochlorine termiticides (pesticides used to control termites) in Hawai‘i. In addition, this fact sheet discusses methods for reducing exposure to organochlorine termiticides during building demolition or around the foundations of treated buildings and identifies resources for further information. What are organochlorine termiticides? Organochlorine termiticides are a group of pesticides that were used for termite control in and around wooden buildings and homes from the mid-1940s to the late 1980s. These organochlorine pesticides included chlordane, aldrin, dieldrin, heptachlor, and dichlorodiphenyltrichloroethane (DDT). They were used primarily by pest control operators in Hawaii’s urban areas, but also by homeowners, the military, the state, and counties to protect buildings against termite damage. In the 1970s and 1980s, the U.S. Environmental Protection Agency (EPA) banned all uses of these organochlorine pesticides except for heptachlor, which can be used today only for control of fire ants in underground power transformers. -
Health Consultation Chevron Chemical Co
- • ! t Health Consultation Chevron Chemical Co. (Ortho Division) Orlando, Orange County, Florida CERCLIS NO. FLD004064242 June 1995 Prepared by Environmental Toxicology The Florida Department of Health and Rehabilitative Services Under a Cooperative Agreement With Agency for Toxic Substances and Disease Registry U.S. Public Health Service Department of Health and Human Services - ' ' Health Consultation - Chevron Chemical June 1995 Background and Statement of Issues The purpose of this health consultation is to interpret the results of indoor air monitoring for pesticides in two trailers adjacent to the Chevron Chemical Superfund site in Orlando, Florida. During a March 9, 1995 public meeting, two nearby residents expressed concerns that the insides of their trailers were contaminated with pesticides. We agreed to test their trailers for pesticide contamination. The Chevron Chemical Co. (Ortho Division) Superfund site is a former pesticide formulation plant and truck repair facility in Orlando, Florida (Figures 1-3, Appendix A). Past waste disposal practices contaminated soil and ground water. Stormwater run-off carried pesticide-contaminated soil to the adjacent Armstrong Trailer Park. In 1992, the Chevron Chemical Company removed the on-site contaminated soil. In 1994, they removed the contaminated soil from the Armstrong Trailer Park. In a 1995 public health assessment (ATSDR 1995), we found the site was a public health hazard because some residents of the adjacent Armstrong Trailer Park may have unknowingly eaten small amounts of soil contaminated with the pesticide chlordane. As a result, we estimated those residents have a moderately increased risk of liver cancer. Since Chevron cleaned up the chlordane-contaminated soil at this trailer park, we estimated the remaining cancer risk from chlordane is insignificant. -
Chronology of Pesticides Used on National Park Service Collections
Conserve O Gram June 2001 Number 2/16 Chronology Of Pesticides Used On National Park Service Collections The history of National Park Service pesticide use publication). Synonyms and trade names were policy for museum collection objects is obtained from the Merck Index, notes from the documented in various publications including IPM Coordinator, and two Internet sites Field Manual for Museums (Burns), Manual for (<http://chemfinder.com> and <http:// Museums (Lewis), versions of the Museum www.cdpr.ca.gov/cgi-bin/epa>). Handbook, Part I, and two versions of the Integrated Pest Management Information Manual. Not all of the chemicals listed in the Other non-policy sources include Coleman's accompanying charts were marketed as pesticides. Manual for Small Museums, object treatment Some are fungicides and microbiocides. One, reports and notes from NPS staff, and notes from Lexol, is a leather preservative and consolidant. the Office of the Integrated Pest Management All of these are included here because records (IPM) Coordinator. indicate they were applied to objects as pesticides. The two accompanying charts list the types of The potential for pesticide residue remaining on pesticides that may have been used on National collection objects is very high. Objects with such Park Service collections along with some common residues pose a health risk to curatorial staff and synonyms and trade names. to the public who come into physical contact with them, unless proper precautions are taken. Dates shown in blue on the chart represent Additional information on health and safety issues published recommendations for the use of and protective measures can be found in the pesticides. -
Chlordane and Toxaphene Residues Following Cooking of Treated Channel Catfish Fillets
763 Journal of Food Protection, Vol. 63, No. 6, 2000, Pages 763±767 Copyright Q, International Association for Food Protection Chlordane and Toxaphene Residues following Cooking of Treated Channel Cat®sh Fillets C. R. SANTERRE,1* R. INGRAM,2 D. H. XU,3 G. W. LEWIS,4 AND L. G. LANE2 1Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-1264; 2Mississippi State Chemical Laboratory, Mississippi State, Mississippi 39762; 3Department of Fisheries and Allied Aquacultures, Auburn University, Auburn, Alabama 36849; and 4Warnell School of Forest Resources, University of Georgia, Athens, Georgia 30602, USA MS 99-215: Received 28 July 1999/Accepted 17 December 1999 Downloaded from http://meridian.allenpress.com/jfp/article-pdf/63/6/763/1673844/0362-028x-63_6_763.pdf by guest on 27 September 2021 ABSTRACT The reduction in residues of chlordane and toxaphene following cooking (frying, baking, and smoking) of ®llets obtained from treated Channel cat®sh (Ictalurus punctatus) was determined. On average, cooking reduced moisture content by 17% and increased fat content by 28 to 274%. Frying reduced chlordane residues by 56 to 86% on a dry basis (db) or 84 to 92% on a percent fat basis (fb) when raw ®llets were compared to cooked ®llets. Baking and smoking reduced chlordane signi®cantly less (P , 0.05) than frying with reductions in residues of 12% and 9% (db) or 30% and 33% (fb), respectively. Frying reduced toxaphene residues by 40 to 49% (db) or 65 to 77% (fb), while baking and smoking reduced toxaphene by 35% and 24% (db) or 51% and 59% (fb), respectively. -
TOXICOLOGICAL PROFILE for CHLORDANE U.S. DEPARTMENT of HEALTH and HUMAN SERVICES Public Health Service Agency for Toxic Subs
TOXICOLOGICAL PROFILE FOR CHLORDANE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry May 1994 CHLORDANE ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. CHLORDANE iii UPDATE STATEMENT A Toxicological Profile for Chlordane was released on December 1989. This edition supersedes any previously released draft or final profile. Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 CHLORDANE vii CONTRIBUTORS CHEMICAL MANAGERS(S)/AUTHOR(S): Henry G. Abadin, M.S.P.H. ATSDR, Division of Toxicology, Atlanta, GA Ronald Baynes, D.V.M., M.S. Paul F. Goetchius, D.V.M. Syracuse Research Corporation, Syracuse, NY THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1 . Green Border Review. Green Border review assures the consistency with ATSDR policy. 2 . Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying endpoints. 3 . Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. 4 . Quality Assurance Review. The Quality Assurance Branch assures that consistency across profiles is maintained, identifies any significant problems in format or content, and establishes that Guidance has been followed. -
Differential Regulation of Endothelium Behavior by Progesterone and Medroxyprogesterone Acetate
P H CUTINI and others Progestins and vascular function 220:3 179–193 Research Differential regulation of endothelium behavior by progesterone and medroxyprogesterone acetate Pablo H Cutini1,2, Adria´n E Campelo1,2 and Virginia L Massheimer1,2 Correspondence should be addressed 1Ca´ tedra de Bioquı´mica Clı´nica II, Departamento de Biologı´a, Bioquı´mica y Farmacia, Universidad Nacional to V L Massheimer del Sur (UNS), San Juan 670, B8000ICN, Bahı´a Blanca, Argentina Email 2Consejo Nacional de Investigaciones Cientı´ficas y Te´ cnicas (CONICET), Argentina, Buenos Aires, Argentina [email protected] Abstract Medroxyprogesterone acetate (MPA) is a synthetic progestin commonly used in hormone Key Words replacement therapy (HRT). The aim of this research was to study and compare the effect of " cell migration progesterone (Pg) and MPA on the regulation of cellular events associated with vascular " medroxyprogesterone homeostasis and disease. Platelet adhesion to endothelial cells (ECs), nitric oxide (NO) acetate production, and cell migration were studied using murine ECs in vitro exposed to the " nitric oxide progestins. After 7 min of treatment, MPA significantly inhibited NO synthesis with respect " progesterone to control values; meanwhile, Pg markedly increased vasoactive production. In senile ECs, " vascular tissue the stimulatory action of Pg decreases; meanwhile, MPA maintained its ability to inhibit Journal of Endocrinology NO synthesis. The presence of RU486 antagonized the action of each steroid. When ECs were preincubated with PD98059 (MAPK inhibitor) or chelerythrine (protein kinase C (PKC) inhibitor) before Pg or MPA treatment, the former totally suppressed the steroid action, but the PKC antagonist did not affect NO production.