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ASB M B Annual Meeting Highlights from the 2009
2010 ANNUAL MEETING, APRIL 24-28. ANAHEIM AWAITS! hlights fr ig om H June 2009 t h e 2 0 0 9 A S B M B A n n u al Meeting American Society for Biochemistry and Molecular Biology ANNUAL REVIEWS A Nonprofit Scientific Publisher INSIGHTFUL ANNUAL REVIEW OF TABLE OF CONTENTS BIOCHEMISTRY Without a License, or Accidents Waiting to Happen, E. Peter Geiduschek RESEARCH IN • A Journey in the World of DNA Rings and Beyond, James C. Wang BIOCHEMISTRY Vol. 78 • JUlY 2009 • The Biochemistry of Disease: Desperately Seeking Syzygy, John W. Kozarich • Biosynthesis of Phosphonic and Phosphinic Acid Natural STARTS WITH Editor: Products, William W. Metcalf, Wilfred A. van der Donk • New Antivirals and Drug Resistance, Peter M. Colman • Multidrug Resistance in Bacteria, Roger D. Kornberg ANNUAL Hiroshi Nikaido • Conformational Pathology of the Serpins: Themes, REVIEWS Stanford University School Variations, and Therapeutic Strategies, Bibek Gooptu, David A. Lomas of Medicine • Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions, Byron Caughey, Gerald S. Baron, Bruce Chesebro, Annual Review of Martin Jeffrey • RING Domain E3 Ubiquitin Ligases, Raymond J. Deshaies, Biochemistry, in publication Claudio A.P. Joazeiro • Regulation and Cellular Roles of Ubiquitin- since 1932, sets the standard Specific Deubiquitinating Enzymes, Francisca E. Reyes-Turcu, Karen H. Ventii, Keith D. Wilkinson • Recognition and Processing of Ubiquitin- for review articles in biological Protein Conjugates by the Proteasome, Daniel Finley • Degradation of chemistry and molecular biology. Activated Protein Kinases by Ubiquitination, Zhimin Lu, Tony Hunter • The Since its inception, these volumes Role of Ubiquitin in the NFκB Regulatory Pathways, Brian Skaug, Xiaomo have served as an indispensable Jiang, Zhijian J. -
Penicillin's Discovery and Antibiotic Resistance
YALE JOURNAL OF BIOLOGY AND MEDICINE 90 (2017), pp.135-145. Perspectives Penicillin’s Discovery and Antibiotic Resistance: Lessons for the Future? Mariya Lobanovska* and Giulia Pilla* Sir William Dunn School of Pathology, University of Oxford, United Kingdom Undoubtedly, the discovery of penicillin is one of the greatest milestones in modern medicine. 2016 marks the 75th anniversary of the first systemic administration of penicillin in humans, and is therefore an occasion to reflect upon the extraordinary impact that penicillin has had on the lives of millions of people since. This perspective presents a historical account of the discovery of the wonder drug, describes the biological nature of penicillin, and considers lessons that can be learned from the golden era of antibiotic research, which took place between the 1940s and 1960s. Looking back at the history of penicillin might help us to relive this journey to find new treatments and antimicrobial agents.This is particularly relevant today as the emergence of multiple drug resistant bacteria poses a global threat, and joint efforts are needed to combat the rise and spread of resistance. FLEMING’S DISCOVERY AND OXFORD’S Experimental Pathology in 1929 [2], where he showed BREAKTHROUGH 1928 TO 1941 that penicillin is able to inhibit bacterial growth in vitro. Fleming thought that penicillin could be useful as a local The discovery of penicillin was much more than just antiseptic, but did not manage to purify penicillin or char- a lucky accident, although it did start with a mistake. In acterize its activity [1,3]. 1928, after returning from holiday, Alexander Fleming, Fleming’s article on penicillin served as a basis for a bacteriologist working at St. -
ACA 2009 Toronto, Ontario Bruker AXS
AMERICAN CRYSTALLOGRAPHIC ASSOCIATION Number 2 Summer 2009 ACA 2009 Toronto, Ontario Bruker AXS HELIOS MX MULTILAYER OPTICS The Ultimate Optic for Protein Crystallography Bruker AXS Inc.‘s HELIOS MX delivers next generation multilayer optics technology that has twice the signal-to-noise ratio of previously available optics. The HELIOS MX optics feature optimized divergence for cell axis up to approximately 150 Å with capability to quickly reduce divergence allowing resolution of large unit cells with axis up to and beyond 450 Å. The HELIOS MX delivers superior data quality from your weakest diffracting samples. www.bruker-axs.com • 1-800-234-XRAY • [email protected] think forward Crystallography American Crystallographic Association ACA HOME PAGE: www.amercrystalassn.org Table of Contents 2 President’s Column 3 Notes from the Treasurer 4 News from Canada 6 ACA Balance Sheet 7 Awards and Notices 8 Les Lessinger (1943-2009) 8-10 Fred Richards (1925-2009) 10 Robert Newnham (1929-2009) 12 Audrey Rossmann (1928-2009) 14-15 ACA Awards -Who was Peggy Etter 16 Texas Teaching Standards on Evolution 17 News from South America 18 WebCS - Cambridge Online 20-21 PSI-SG Knowledgebase 21-22 6th Annual SER-CAT Symposium 24-25 Book Reviews 26-30 President Obama Speaks at the NAS 30 Galileoscopes 31 ACA Corporate Members 32-40 Candidates for ACA Offices in 2010 42 ACA 2009 - Travel Grantees Contributors to this Issue 43 ACA 2009 - SIG Lecturers - Sponsors - Exhibitors 44 Calendar of Future Meetings Index of Advertisers What’s on the Cover Contributions to ACA RefleXions may be sent to either of the Editors: Please address matters pertaining to advertisements, membership inquiries, or use of the ACA mailing list to: Connie Rajnak ......................................... -
Pages 459 To
459 University Organization Board of Trustees The dean of the Heller School for Social study abroad, international students and Policy and Management oversees the scholars, and student enrichment services), academic activities of the school and its Hiatt Career Center, research and planning, Under Massachusetts law, the Board of work in such policy areas as children, and student life (including athletics, Trustees is the governing body of the youth, families, health, mental health, chaplaincy, community service, health university. There are four faculty substance abuse, disabilities, aging, social services, intercultural center, judicial representatives and three student change, and economic inequalities. orientation, psychological counseling, representatives to the board who participate residence life, and student activities). in board meetings and have votes on the The dean of the Brandeis International several committees. The president of the Business School oversees the academic, The senior vice president for university, the chair of the Fellows, the professional, and development activities communications administers and executes president of the Brandeis National of the university’s second professional critical university-wide internal and Committee, and the president of the school. Research areas of the school external communications, overseeing the Alumni Association serve ex officio. The include economic policy, finance, global communications emergency response plan board annually elects an alumni term entrepreneurship, international business, and directing all crisis communications. trustee who serves a four-year term with regional economics integration, and trade Further, she is responsible for an integrated full voting privileges. and exports. marketing communications program that highlights Brandeis’s research The President accomplishments, academic excellence, The president, the chief executive officer of The Faculty Senate social justice mission, and scholarly the university, is appointed by the Board of contributions to the Jewish community. -
2014-Program-For-Lecture-Gregory
OKLAHOMA SCHOOL OF SCIENCE AND MATHEMATICS Oklahoma stands out among other states in our dedication to providing OSSM an outstanding science and mathematics education to its gifted students at a time when our nation falls behind other countries in these areas. Senator Penny Williams Distinguished Lecture Series With just 22 classes graduated, OSSM alumni/alumnae are already Presents bringing substantial benefits to our state as they complete their degrees and move into their professions. “How Parkinson’s Disease Starts and •••••••••••••••••••••••• How It Might Be Stopped” • Eighty-five percent of OSSM alumni are remaining in scientific, technology, By engineering, and mathematics (STEM) fields for their careers! 2014 Capra Scholar • Of OSSM graduates now employed (many are still in undergraduate and graduate school or completing residencies in medical school), more than 60% GreGory A. PetSko, D.PHIl. are employed in Oklahoma. The fields of study and careers most chosen by OSSM graduates are engineering Arthur J. Mahon Professor of Neurology and Neuroscience and • Director, Helen and Robert Appel Alzheimer’s Disease Research Institute Weill Cornell Medical College (aerospace, biomedical, chemical, civil, computer, electrical, mechanical, Adjunct Professor of Biomedical Engineering Cornell University petroleum); medicine, medical research, and other health sciences; and other fields including computer science, technology, education, scientific research, Gyula and Katica Tauber Professor of Biochemistry and Chemistry, Emeritus Brandeis University business, and law. Adjunct Professor of Neurology Harvard Medical School Many OSSM alums are employed in many of Oklahoma’s finest corporations, Past-President, American Society for Biochemistry and Molecular Biology • President, International Union of Biochemistry and Molecular Biology hospitals and technical firms such as AT&T, Artificial Lift Company, Baptist Hospital, Benham Companies, Boeing, Chesapeake Energy, C. -
Biophysical Society 58Th Annual Meeting February 15–19, 2014 | San Francisco, California
ABSTRACT DEADLINE: OCTOBER 1, 2013 | EARLY REGISTRATION DEADLINE: JANUARY 8, 2014 Biophysical Society 58th Annual Meeting FEBRUARY 15–19, 2014 | SAN FRANCISCO, CALIFORNIA BIOPHYSICS OF CELL DIVISION AND National Lecturer SPATIAL RELATIONSHIPS Workshops Susan Biggins, Fred Hutchinson Cancer Workshops will be held on Sunday and Carlos Bustamante Research Center, Co-Chair Tuesday evenings. University of California, Berkeley Wallace Marshall, University of California, San Francisco, Co-Chair POLARIZABLE FORCE FIELDS FROM Daniel Fletcher, University of California, BIOMOLECULAR SIMULATIONS A Journey Through Cellular Processes: Berkeley One Molecule at a Time Matthieu Piel, Curie Institute, France Benoit Roux, University of Chicago, Co-Chair Alexander Mackerell, University FORCE GENERATION IN CELL AND of Maryland, Co-Chair TISSUE NETWORKS Vijay Pande, Stanford University Michael Sheetz, Columbia University, MOLECULAR BASIS FOR REGULATION Teresa Head-Gordon, University Co-Chair Symposia 2+ of California, Berkeley OF CA CHANNELS Clare Waterman, NHLBI, Co-Chair Stephen Long, Memorial Sloan- Symposia will be held Sunday through Alexander Bershadsky, Weizmann Kettering Cancer Center, Co-Chair SINGLE MOLECULE DYNAMICS USING Wednesday. Institute of Science, Israel FRET/LRET Amy Lee, University of Iowa, Co-Chair Frank Jülicher, Max Planck Institute for the Achillefs Kapanidis, University of Annette Dolphin, University College Physics of Complex Systems, Germany FORCE SENSING IN MUSCLE London, United Kingdom Oxford, United Kingdom, Co-Chair Mathias Gautel, -
Experimentally Demonstrated the Intrinsic Instability of the Fluorite-Type Zr Cation Network
0246110 Rta(i) 1 1,2 l,4 1,6 1,l 2 22 Rta(i) Figure 2. Temperature dependence of Zr-FTfor pure orthorhombic zirconia Figure 3 Temperature dependence of Zr-0 shell in tetragonal zirconia solid solution Our study has experimentally demonstrated the intrinsic instability of the fluorite-type Zr cation network. Coherent scattering beween Conclusions central Zr ion and distant cations is weaker and vibration modes of the Zr-cation network are It is found that, for all of zirconia solid softer in tetragonal zirconia than in monoclmic, solutions studied, the dopant-oxygen distances are orthorhombic, or stabilized cubic zirconia. In si@icantly ddferent from the Zr-0 distances. addition, the outer foux oxygens in the 8-fold The dopant-cation distances, on the other hand, coordinated Zr-0 polyhedron are only loosely are usually very close to the Zr-Zr distance, solutions. A bonded and are subject to very large static and confirming the formation of solid dynamic distortions. This effect is illustrated by general structural picture for zirconia solid the expanded portion of the Fourier transform solutions is one that places the dopant cations shown in Figure 3. randomly on tbe Zr sites in the cation network, but with distorted and sometimes very different Dopant Structure dopant-oxygen polyhedra surrounding these dopants. In the case of Ge4+ doping and Y-Nb We have also successfully performed co-doping, short-rangecation ordering has been EXAFS experiments at the dopant absorption suggested from our EXAFS results. edges for doped zirconia solid solutions. Dopants Based on the above structural information studied include the Ce-,Nb-, and Y-K edges as and other EXAFS results obtained from NSLS, well as Ce-LIn edge. -
Cell Biology in Sudan
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/290440842 Science on the Banks of the Nile: Cell Biology in Sudan Article · September 2014 READS 162 4 authors, including: Marmar A. El Siddig Adil Ali EL Hussein University of Khartoum University of Khartoum 40 PUBLICATIONS 25 CITATIONS 44 PUBLICATIONS 67 CITATIONS SEE PROFILE SEE PROFILE Sakina Yagi University of Khartoum 36 PUBLICATIONS 174 CITATIONS SEE PROFILE Available from: Marmar A. El Siddig Retrieved on: 17 May 2016 ASCB MARCH 2014 NEWSLETTER VOLUME 37, NUMBER 2 The ASCB in 2018 Page 3 ASCB Task Force to Explore Annual Meeting Reproducibility of Scientific Data Highlights The apparent irreproducibility of some published scientific Page 9 results is an issue of growing concern to industry and to the scientific community. It has begun to receive attention in the news media as well, and if one believes the popular press as MBoC Call for Papers much as 80% of scientific research cannot be reproduced. Is in Quantitative that really true? Does that apply to all research or just some Biology areas? These are just two of the questions a task force of the Page 36 ASCB’s Public Policy Committee (PPC) will attempt to answer as it conducts an in-depth analysis of the issue. If reports of widespread difficulty in reproducing published Inside research results are true, it is a problem that could threaten the scientific enterprise and undermine the authority of the COMPASS Outreach Awards 2 scientific community. In his charge to the task force, ASCB Executive Director’s Column 3 Executive Director Stefano Bertuzzi listed four potential causes for difficulties in reproducing results: DORA Panel Discussion 9 n A hyper-competitive culture that overemphasizes results BSCB Young Cell Biologist 10 n A bias in favor of positive results Young French Cell Biologists 11 Reproducibility, continued on p.17 Mark Winey Local Meeting Highlights 12 Nominate a Colleague for an ASCB Award! Deadline April 1. -
IUBMB Newsletter Issue 2.Pdf
IUBMB NEWS Issue 2 October 2016 President’s Message IUBMB aims to promote research and education in In This Issue Biochemistry and Molecular Biology. In this regard, over the President’s Message years we have channelled great efforts into the research aspects of our science. We now consider it timely to turn our Report on the 16th IUBMB attention to educational initiatives. Conference / Young To address this aim and in collaboration with FEBS, we are organising a conference on Education in Biochemistry and Molecular Biology, to be held in Scientists’ Program Rehovot (Israel) in September 2017. The conference seeks to provide a think-tank Tang Prize Foundation setting in which to draw up ideas to improve the current approach to teaching these subjects, and to generate a series of recommendations to be shared with Awardees / IUBMB Travel the educational community. In this regard, this conference will serve to propel the Fellowships changes that are required to bring education in biochemistry and molecular biology st at all levels into the 21 century. Another Way to Think About Another important aspect of education is to provide young scientists from Disease by Gregory Petsko developing countries the opportunity to attend international congresses and meetings. IUBMB is firmly committed to this endeavour and devotes significant Retrospective — financial resources to this end. Given that the number of applications from African countries is very low, I wish to encourage our young African colleagues to apply Osamu Hayaishi and benefit from IUBMB travel awards and Wood-Whelan fellowships. An Appreciation — IUBMB is also launching a new activity, namely Focused Meetings. -
FALL2015.Pdf
Introducing… In Meso In Situ Serial Crystallography mitegen.com/imisx Easy Crystallizaon in LCP • Simple in situ X-ray Diffracon • Standard Goniometer Compable • Serial Crystallography Enabling • Advanced Dual-Sandwich Design Rethink what your LCP crystallizaon plate is capable of. EZ-Cut LCP LCP Tools Easy Access LCP Crystallizaon Plate Starter Kits, Syringes, Lipids & More Take your crystallizaon in LCP to the next level with MiTeGen’s new LCP line mitegen.com/lcp ACA - Structure Matters www.AmerCrystalAssn.org Table of Contents 2 President’s Column 2-4 News from Canada 4 From the Editor's Desk 5-6 Update on Structural Dynamics Chris Cahill 7 What's on the Cover ACA President 8-11 Poster Prizes in Philadelphia 12 Undergraduate Student Reception in Philadelphia Contributors to this Issue What's on the Cover 13-51 Philadelphia ACA Meeting Page 7 21 Index of Advertisers 53-54 2015 ACA Summer Course 56 What's New on the ACA History Website Spotlight on Stamps Juanma García-Ruiz Net RefleXions 15 Plenary Lecturer in Philadelphia 58-59 Puzzle Corner 59 YSSIG Activities 60-61 48th Erice International School of Crystallography 61-62 Updates from 2014-2015 AIP Science & Technology Fellows 62 CSD50 Symposium Daniel Rabinovich 64-65 News & Awards Spotlight on Stamps 65-66 Book Reviews 66-67 2015 Wisconsin Crystal-Growing Competition 68 Net RefleXions 69 CCDC Data Deposition Service Enhancement 70-71 ACA 2016 Denver Preview 72 Future Meetings Anastasiya Vinokur Net RefleXions Contributions to ACA RefleXions may be sent to either of the Editors: Please address matters pertaining to advertisements, membership Judith L. -
Frederic M. Richards 1925–2009
Frederic M. Richards 1925–2009 A Biographical Memoir by Robert L. Baldwin and George D. Rose ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the National Academy of Sciences. FREDERIC MIDDLEBROOK RICHARDS August 19, 1925–January 11, 2009 Elected to the NAS, 1971 Frederic M. Richards (who preferred to be called Fred) is remembered as a guiding influence in 20th century protein chemistry and structural biology. In a landmark 1957 exper- iment, he discovered that the proteolytic enzyme subtilisin cuts the protein ribonuclease into two inactive fragments which, when mixed, associate spontaneously and restore activity completely. This single experiment at once estab- lished the field of protein molecular recognition, showing, for example, how peptide hormones might activate their protein receptors. Later, Fred pioneered computational approaches for analyzing and interpreting protein struc- tures that remain in widespread use today. He was the founding chair of the Department of Molecular Biophysics and Biochemistry at Yale, which became the world’s By Robert L. Baldwin and George D. Rose preeminent department of molecular biophysics soon after its inception. He was an outspoken critic against the social forces that erode time and trivialize achievement. He served the scientific community at large in many influential roles, and his work garnered many of the most prestigious awards. Fred was a natural leader with a charismatic, fun-loving personality. He cherished life and reveled in ideas, conversation, the sheer joy of doing, and, especially, sailing. For Fred, a quintessential part of the full life was to spend at least 4 to 6 weeks a year sailing. -
Democritus Universtity of Thrace Department of Molecular Biology and Genetics Undergraduate Prospectus 2009-2010
DEMOCRITUS UNIVERSTITY OF THRACE DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS UNDERGRADUATE PROSPECTUS 2009-2010 ALEXANDROUPOLIS ENTRY 2009 i Turkey Thessaloniki MBG Alexandroupolis Nea Chili Makri Department of Medicine MBG University Hospital Nea Chili ADDRESS Democritus University of Thrace Department of Molecular Biology and Genetics, 6th km Alexandroupolis-Makris University Campus, Dragana, GR. 68100 WEBSITE www.mbg.duth.gr INFORMATION Τel: (+30)25510/30610, 30612,30614 FAX: (+30) 25510/30613 The prospectus was organized by Dr C.Staneloudi and M.Grigoriou, Assistant Professor ii CONTENTS ACADEMIC DIARY 2009-2010………………………..…………………………………………………..v A Preface By The President…………………………………………………………………………………vi PART Ι: GENERAL INFORMATION.…………………………………………………………………...1 DEMOCRITUS UNIVERSITY OF THRACE (D.U.TH)………………………………………………....2 1. The University………………………………………………………………………………….....2 2. Administration………………………………………………………………………………….....3 THE DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS (M.B.G)……………………..4 1. The Department…………………………………………………………………………………...4 2. Administration and Teaching Staff…………………………………………………………….....5 3. Divisions………………………………………………………………..........................................6 4. Admission ………………………….....................................................................………………..7 PART ΙI: STUDYING IN M.B.G……………………………………………………………............……..8 1. Rules and Regulations of Exams and Evaluation……………………............................................9 2. Requirements for Graduation………………………………………..................…………………9