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The Effects of NMDA Receptor Antagonists on Attentional Set-Shifting Task Performance in Mice
Psychopharmacology (2011) 214:911–921 DOI 10.1007/s00213-010-2102-6 ORIGINAL INVESTIGATION The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice Tomasz Kos & Agnieszka Nikiforuk & Dominik Rafa & Piotr Popik Received: 29 April 2010 /Accepted: 11 November 2010 /Published online: 16 December 2010 # The Author(s) 2010. This article is published with open access at Springerlink.com. Abstract a facilitation of cognitive flexibility. Finally, as revealed by the Rationale and objectives Cognitive deficits, including an number of trials and time to criterion measures, Ro 25-6981 impaired ability to shift perceptual attentional set, belong to (10 mg/kg) administration to ketamine (10 mg/kg)-pretreated the core features of schizophrenia, are associated with mice inhibited ketamine-induced cognitive inflexibility. prefrontal cortical dysfunctions, and may involve glutamate Conclusion The present study provides an improved and NMDA receptors. Although phencyclidine disturbs cogni- reliable mouse ASST protocol and confirms and extends tive flexibility, little is known about the effects of ketamine previous findings demonstrating that NR2B subunit- and other NMDA antagonists that differ in receptor subunit selective antagonists improve cognitive processes. selectivity, particularly in the mouse species. Methods At different times following the administration of Keywords Ketamine . NMDA receptor antagonist . ketamine, the NMDA NR2B-subtype specific antagonist NR2B-selective antagonist . Mouse . Cognition . Ro 25-6981, -
Society Register
ISSN 2544-5502 SOCIETY REGISTER 4 (4) 2020 Adam Mickiewicz University in Poznan ISSN 2544-5502 SOCIETY REGISTER 4 (4) 2020 Adam Mickiewicz University in Poznan SOCIETY REGISTER 2020 / Vol. 4, No. 4 ISSN: 2544-5502 | DOI: 10.14746/sr EDITORIAL TEAM: Mariusz Baranowski (Editor-in-Chief), Marcos A. Bote (Social Policy Editor), Piotr Cichocki (Quantitative Research Editor), Sławomir Czapnik (Political Science Editor), Piotr Jabkowski (Statistics Editor), Mark D. Juszczak (International Relations), Agnieszka Kanas (Stratification and Inequality Editor), Magdalena Lemańczyk (Anthropology Editor), Urszula Markowska-Manista (Educational Sciences Editor), Bartosz Mika (Sociology of Work Editor), Kamalini Mukherjee (English language Editor), Krzysztof Nowak-Posadzy (Philoso- phy Editor), Anna Odrowąż-Coates (Deputy Editor-in-Chief), Aneta Piektut (Migration Editor). POLISH EDITORIAL BOARD MEMBERS: Agnieszka Gromkowska-Melosik, Adam Mickiewicz University in Poznań (Poland); Kazimierz Krzysztofek, SWPS University of Social Sciences and Humanities (Poland); Roman Leppert, Kazimierz Wielki University (Poland); Renata Nowakowska-Siuta, ChAT (Poland); Inetta Nowosad, University of Zielona Góra (Poland); Ewa Przybylska, Nicolaus Copernicus University in Toruń (Poland); Piotr Sałustowicz, SWPS University of Social Sciences and Humanities (Poland); Bogusław Śliwerski, University of Lodz (Poland); Aldona Żurek, Adam Mickiewicz University in Poznań (Poland). INTERNATIONAL EDITORIAL BOARD MEMBERS: Tony Blackshaw, Sheffield Hallam University (United King- dom); Theodore Chadjipadelis, Aristotle University Thessaloniki (Greece); Kathleen J. Farkas, Case Western Reserve University, Cleveland, Ohio (US); Sribas Goswami, Serampore College, University of Calcutta (India); Bozena Hautaniemi, Stockholm University (Sweden); Kamel Lahmar, University of Sétif 2 (Algeria); Georg Kam- phausen, University of Bayreuth (Germany); Nina Michalikova, University of Central Oklahoma (US); Jaroslaw Richard Romaniuk, Case Western Reserve University, Cleveland, Ohio (US); E. -
Environmental and Therapeutic Modulators of Neuropsychiatric Disease
Environmental and therapeutic modulators of neuropsychiatric disease PhD Thesis Dissertation for the award of the degree “Doctor of Philosophy” (Ph.D.) at the Georg-August-University, Göttingen Faculty of Biology submitted by Bartosz Tomasz Adamcio born in Kożuchów, Poland Göttingen 2009 Members of the Thesis Committee Prof. Dr. Dr. Hannelore Ehrenreich (Reviewer) Division of Clinical Neuroscience Max-Planck-Institute for Experimental Medicine Göttingen Prof. Dr. Ralf Heinrich (Reviewer) Department of Neurobiology Institute for Zoology and Anthropology Georg-August-University Göttingen Prof. Dr. Ursula Havemann-Reinecke Department of Psychiatry and Psychotherapy Georg-August-University Göttingen Date of the oral examination: 2 DECLARATION I hereby declare that this submission is my own work and that, to the best of my knowledge and belief, it contains no materials previously published or written by another person nor material which to a substantial extent has been accepted for the award of any other degree of the university or other institute of higher education, except where due acknowledgement has been made in the text. Bartosz Tomasz Adamcio Göttingen, 29 September 2009 3 ACKNOWLEDGEMENTS In the first place I would like to thank Prof. Dr. Dr. Hannelore Ehrenreich for giving me the opportunity to work with her in the Division of Clinical Neuroscience at Max-Planck-Institute for Experimental Medicine. I am extremely grateful for her supervision and support throughout my PhD years. Above all, I would like to thank for her wonderful enthusiasm, boundless motivation and her trust. I owe many thanks to Prof. Ursula Havemann-Reinecke and Prof. Ralf Heinrich for their supportive contributions as members of my thesis committee. -
The Continued Need for Animals to Advance Brain Research
ll NeuroView The continued need for animals to advance brain research Judith R. Homberg,1,* Roger A.H. Adan,7 Natalia Alenina,15 Antonis Asiminas,23,24 Michael Bader,15 Tom Beckers,20 Denovan P. Begg,38 Arjan Blokland,10 Marilise E. Burger,33 Gertjan van Dijk,6 Ulrich L.M. Eisel,6 Ype Elgersma,3 Bernhard Englitz,2 Antonio Fernandez-Ruiz,35 Carlos P. Fitzsimons,5 Anne-Marie van Dam,9,40 Peter Gass,19 Joanes Grandjean,1 Robbert Havekes,6 Marloes J.A.G. Henckens,1 Christiane Herden,12,13 Roelof A. Hut,6 Wendy Jarrett,22 Kate Jeffrey,39 Daniela Jezova,30 Andries Kalsbeek,8,9 Maarten Kamermans,8,9 Martien J. Kas,6 Nael Nadif Kasri,1 Amanda J. Kiliaan,1 Sharon M. Kolk,2 Aniko Korosi,5 S. Mechiel Korte,43 Tamas Kozicz,36 Steven A. Kushner,3 Kirk Leech,31 Klaus-Peter Lesch,16,17,18 Heidi Lesscher,11 Paul J. Lucassen,5 Anita Luthi,29 Liya Ma,2 Anne S. Mallien,19 Peter Meerlo,6 Jorge F. Mejias,5 Frank J. Meye,7 Anna S. Mitchell,21 Joram D. Mul,5 (Author list continued on next page) 1Radboud University Medical Center, Nijmegen, the Netherlands 2Radboud University, Nijmegen, the Netherlands 3Erasmus Medical Center, Rotterdam, the Netherlands 4Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 5Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands 6Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands 7University Medical Center Utrecht, Utrecht, the Netherlands 8Netherlands Institute for -
Morphine Tolerance and Reward but Not Expression Of
Neuropsychopharmacology (2003) 28, 457–467 & 2003 Nature Publishing Group All rights reserved 0893-133X/03 $25.00 www.neuropsychopharmacology.org Morphine Tolerance and Reward but not Expression of Morphine Dependence are Inhibited by the Selective Glutamate Carboxypeptidase II (GCP II, NAALADase) Inhibitor, 2-PMPA ,1 1 = 1 2 2 Piotr Popik* , Ewa Kozela , Malgorzata Wro´bel , Krystyna M Wozniak and Barbara S Slusher 1 2 Institute of Pharmacology, Polish Academy of Sciences, Krako´w, Poland; Guilford Pharmaceuticals Inc., Baltimore, USA Inhibition of glutamate carboxypeptidase II (GCP II; NAALADase) produces a variety of effects on glutamatergic neurotransmission. The aim of this study was to investigate effects of GCP II inhibition with the selective inhibitor, 2-PMPA, on: (a) development of tolerance to the antinociceptive effects, (b) withdrawal, and (c) conditioned reward produced by morphine in C57/Bl mice. The degree of tolerance was assessed using the tail-flick test before and after 6 days of twice daily (b.i.d.) administration of 2-PMPA and 10 mg/kg of morphine. Opioid withdrawal was measured 3 days after twice daily morphine (30 or 10 mg/kg) administration, followed by naloxone challenge. Conditioned morphine reward was investigated using conditioned place preference with a single morphine dose (10 mg/kg). High doses of 2-PMPA inhibited the development of morphine tolerance (resembling the effect of 7.5 mg/kg of the NMDA receptor antagonist, memantine) while not affecting the severity of withdrawal. A high dose of 2-PMPA (100 mg/kg) also significantly potentiated morphine withdrawal, but inhibited both acquisition and expression of morphine-induced conditioned place preference. -
Florian Znaniecki ’ S Teory of Civilization
■ STUDIE Crisis or Fluidity? Florian Znaniecki ’ s Teory of Civilization ELŻBIETA HAŁAS* Krize, nebo tekutost? Teorie civilizace Floriana Znanieckého Abstract: Te preoccupation with the processes of globalization, which has become a key concept in the analysis of the sociocultural condition of postmodernity, has led to a decreased interest in the theory of civilization. Te ideological burden of the concept of civilization and its stigmati- zation by critics of post-Enlightenment modernity also contribute to this current state. However, issues associated with the processes of civilization have once again come to the fore, as shown by the reconstruction of threads associated with civilization in social theory, including sociological works. Te views on civilization presented by Weber, Durkheim and Mauss, by their successors Sorokin, Elias and Nelson, down to the contemporary publications of Huntington and Eisenstadt are widely known, whereas works published on this subject in Polish by Florian Znaniecki are not. On a backdrop of the genesis of civilization-associated discourse and its antinomy as regards religion, the article presents Znaniecki ’ s concept of civilization processes as the social integration of culture, developed on the basis of his theory of cultural and social systems. Two types of human participation in culture are signifcant here: cultural communities and social groups which create a cultural bond. Te de-civilizing processes which Znaniecki described are shown. Te article analyzes Znaniecki ’ s idea of a fuid civilization and the conditions which are necessary for its existence, in the shape of refexive cultural knowledge as the answer to a cultural crisis. Te new type of cultural crisis stems from cultural innovations. -
POLITICAL IDEOLOGIES András Bozóki Professor, Dept. of Political
Win POLITICAL IDEOLOGIES András Bozóki Professor, Dept. of Political Science, CEU, Vienna [email protected] MA course, 4 credits, Fall semester, 2020. #D318, Monday at 1.30pm and Wednesday at 3.30pm Description: The purpose of the course is to give a comprehensive overview to the modern political ideologies. The course starts off with the concept of ideology itself, in both historical and post-Cold War context, by paying attention to the linguistic turn in historiography in clarifying different approaches to ideology vs discourse.Then, we examine major ideologies such a way in which we shall discuss the theoretical considerations first, and then the impact of these ideas. The course aim to put these ideologies into the context of social and political practice. Beside some 'classic' ideologies (liberalism, conservatism, socialism, anarchism, fascism, nationalism etc.) which all had significant impact in the history of ideas, we will discuss some 'new' ideologies (feminism, ecologism, new left, new right) and issues in democratic political participation in the era of globalization) will be discussed. We will follow the main debates on ideology too. Learning outcome: Students will be able to understand and analyze different political arguments in their wider, ideological context and they will be more sophisticated in dealing with the cultural, ideological and social embeddedness of political actions, discourses, and rhetorics. The course will enhance the students’ critical thinking in revealing and uncovering one of the major components (i.e. ideology) has been present in the history of politics and political ideas. Grade components: Students are required to follow the readings before each meeting, to attend the seminars, participating actively in the class discussions, and, if asked, introducing the readings of the week (20%). -
Acta 114.Indd
PRO MEMORIA Acta Poloniae Historica 114, 2016 PL ISSN 0001–6829 JERZY RYSZARD SZACKI (6 FEBRUARY 1929 – 25 OCTOBER 2016) Born 6th February 1929 in Warsaw, Jerzy Ryszard Szacki began his studies in sociology at the University of Warsaw after the Second World War (in 1948) and associated himself with his Alma Mater for the rest of his professional life. He got his PhD in 1959, a postdoctoral (‘habilitation’) degree in 1965, and became a professor in 1973. Once retired (1999), he continued his research and worked with his PhD students on an individual basis. In 2003–9 Szacki was a professor with the University of Social Sciences and Humanites in Warsaw (SWPS). Since 1984, he cooperated regularly with the Vienna-based Institute for Human Sciences, which he visited a number of times as a guest or visiting fellow. From the early 1990s until his last days, he was member of the Institute’s Academic Advisory Board; 1995 saw him join a seminar contributed by the Institute and held at the Castel Gandolfo, with Pope John Paul II among the attendees. Within more than fi fty years of his activity, Szacki often received scholarships with prestigious scientifi c institutions of Europe and the United States. His functions or titles included Associate Dean and Dean of the Warsaw University’s Faculty of Philosophy and Sociology, Chair of the Polish Sociological Association, editor with The Polish Sociological Review, chairmanship of the Committee of Sociology, Polish Academy of Sciences, and membership with the said Academy. Jerzy Szacki has successfully tutored dozens of MA and a total of twenty-seven doctoral students. -
The University of Chicago Mechanisms Underlying Ocd
THE UNIVERSITY OF CHICAGO MECHANISMS UNDERLYING OCD-RELEVANT BEHAVIORS IN MICE A DISSERTATION SUBMITTED TO THE FACULTY OF THE DIVISION OF THE BIOLOGICAL SCIENCES AND THE PRITZKER SCHOOL OF MEDICINE IN CANDIDACY FOR THE DEGREE OF DOCTOR OF PHILOSOPHY COMMITTEE ON NEUROBIOLOGY BY SUMMER LORETTA THOMPSON CHICAGO, ILLINOIS DECEMBER 2017 Copyright © 2017 by Summer Loretta Thompson All Rights Reserved TABLE OF CONTENTS LIST OF FIGURES . vii LIST OF TABLES . viii ACKNOWLEDGMENTS . ix ABSTRACT . xi 1 GENERAL INTRODUCTION . 1 1.1 Obsessive-compulsive disorder .......................... 1 1.1.1 Background ................................ 1 1.1.2 Neural circuitry .............................. 1 1.1.3 Psychiatric genetics and OCD ...................... 2 1.2 Animal models of OCD: a conceptual framework ................ 4 1.2.1 Can an animal have OCD? ........................ 4 1.2.2 Validity .................................. 5 1.2.3 Diagnostic boundaries and endophenotypes . 10 1.2.4 Mechanisms, disease models, and behavioral tests . 12 1.2.5 Utility ................................... 13 1.3 Pharmacological and behavioral rodent models of obsessive-compulsive disorder 18 1.3.1 OCD background ............................. 18 1.3.2 Principles of animal modeling ...................... 20 1.3.3 Pharmacologically induced models of obsessive-compulsive disorder . 24 1.3.4 Environmentally induced models .................... 30 1.3.5 Spontaneous models ........................... 32 1.3.6 Conclusions ................................ 35 2 DISTINCT ROLES FOR β-ARRESTIN2 AND GSK-3 SIGNALING IN 5-HT1BR- MEDIATED PERSEVERATIVE BEHAVIOR AND PREPULSE INHIBITION DEFICITS IN MICE . 37 2.1 Introduction .................................... 37 2.2 Materials and methods .............................. 40 2.2.1 Animals .................................. 40 2.2.2 Drugs ................................... 40 2.2.3 Behavioral testing ............................. 41 2.2.4 Experiments ................................ 42 2.2.5 Statistical analysis ........................... -
Law As Tradition Author(S): Martin Krygier Reviewed Work(S): Source: Law and Philosophy, Vol
Law as Tradition Author(s): Martin Krygier Reviewed work(s): Source: Law and Philosophy, Vol. 5, No. 2 (Aug., 1986), pp. 237-262 Published by: Springer Stable URL: http://www.jstor.org/stable/3504690 . Accessed: 16/03/2012 09:29 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. Springer is collaborating with JSTOR to digitize, preserve and extend access to Law and Philosophy. http://www.jstor.org MARTIN KRYGIER LAW AS TRADITION* ABSTRACT. This essay argues that to understand much that is most central to and characteristic of the nature and behaviour of law, one needs to supple- ment the 'time-free' conceptual staples of modern jurisprudence with an understanding of the nature and behaviour of traditions in social life. The article is concerned with three elements of such an understanding. First, it suggests that traditionality is to be found in almost all legal systems, not as a peripheral but as a central feature of them. Second, it questions the post- Enlightenment antinomy between tradition and change. Third, it argues that in at least two important senses of 'tradition', the traditionality of law is inescapable. Legal philosophers disagree about many things, few more than the nature of law. -
SPECIAL SECTION on POLISH ANTHROPOLOGY 5: Review Article
SPECIAL SECTION ON POLISH ANTHROPOLOGY 5: Review Article THE MALINOWSKI CENTENARY CONFERENCE: CRACOW 1984 GRAZYNA KUBICA and JANUS Z MUCHA (eds.), Mi~dzy Dwana a,iatami - B~onislaw Malinowski [Be~~een Two Worlds: Bronislaw Malinowski], Wars~_wa and Krakow: Panstwowe Wydawnictwo Naukowa 1985. 195pp.~ English summaries. !his book contains the speeches and papers delivered at the Malin owski Centenary Conference held in Cracow in September 1984 under the auspices of the Jagiellonian University, where Malinowski once studied. It was one of four conferences held that year to mark the occasion, the others being in London in April, New Haven in October, and Florence in November. For several reasons, the Cra cow conference may have been the most significant. Effectively for the first time, Polish academia publicly embraced Malinowski as a long-lost national hero. It also marked the first real entry of Polish anthropologists into the international academic arena. Considering the political situation in Poland, it is not surpris- that they had to wait for such an event of international im portance and then use Malinowski as a national symbol in order to establish an academic dialogue with the West. Subsequent contact between Oxford and Cracow anthropologists has been particularly constructive, especia since the establishment of the 'Polish Hospitality Scheme', which has made it possible for Polish anthro pologists as well as other scholars from Poland - to visit Ox ford University on a short-term basis. In September 1985 the Jagiellonian University hosted another international conference, on the subject of 'Ritual: Sacred and Secular'; a forthcoming con ference, to be held in January 1987, is to be on 'Identity'. -
Effects of Memantine, an NMDA Receptor Antagonist, on Place Preference Conditioned with Drug and Nondrug Reinforcers in Mice P
Original article 237 Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice P. Popika, M. Wrobela, R. Rygulaa, A. Bisagab and A.Y. Bespalovc Antagonists of the N-methyl-D-aspartate (NMDA) receptor tioned with morphine and sexual encounter, but had no complex have been shown to inhibit the expression of effects in food-conditioned mice. These findings suggest place preferences conditioned with several drugs that are that the effects of NMDA receptor blockade may not be abused by humans, which suggests that this class of limited to drug-reinforced behaviors. Behavioural Phar- compounds may be beneficial in the treatment of sub- macology 14:237–244 c 2003 Lippincott Williams & stance dependence. Therefore it is important to assess the Wilkins. specificity of this effect, of whether inhibitory effects of NMDA receptor antagonists on conditioned drug stimuli Behavioural Pharmacology 2003, 14:237–244 generalize to behaviors produced by nondrug reinforcers. Keywords: conditioned place preference, NMDA receptor antagonist, The present study was designed to compare the effects of memantine, morphine, sexual interaction, food reward, mouse the NMDA receptor channel blocker, memantine, on the aInstitute of Pharmacology, Polish Academy of Sciences, Krako´ w, Poland, expression of place preferences conditioned with: bDepartment of Psychiatry, Columbia University College of Physicians and (1) consumption of regular laboratory food; (2) sexual Surgeons, New York, USA and cInstitute of Pharmacology, Pavlov Medical encounters with females; and (3) injection of morphine University, St. Petersburg, Russia. (10 mg/kg) in adult male Swiss mice. For all three Sponsorship: This study and preparation of the manuscript were supported by experiments reported here, unconditioned stimuli (food, Institute of Pharmacology Statutory Activity, State Committee for Scientific Research (KBN grant No P05A.