US5478848.Pdf
||||||||||| US005478848A United States Patent (19) 11 Patent Number: 5,478,848 Aune 45) Date of Patent: Dec. 26, 1995 54) INHIBITION OF ARTHRITIS BYL-TYPE Kong et al., Second Messenger Phosphoproteins 13, CALCIUM CHANNEL ANTAGONSTS 117-130 (1991). NIMODIPINE, NISOLDIPINE AND Olsen et al., Biochem. Biophys. Res. Commun. 162,448-455 NFEDIPINE (1989). Dayer and Demczuk, Cytokines and Other Mediators in 75) Inventor: Thomas M. Aune, Hamden, Conn. Rheumatoid Arthritis, Springer Seminars in Immunopathol ogy, pp. 1-27 (Springer-Verlag 1984). 73) Assignee: Bayer Corporation, Pittsburgh, Pa. Gay and Koopman, Current Opinion in Rheumatology 1, 8-14 (1989). (21) Appl. No.: 188464 Brennan et al., The Lancet Jul. 29, 224-247 (1989). Taurog et al., Meth. Enzymol. 162, 339-355 (1988). (22 Filed: Jan. 26, 1994 Otterness and Bliven et al., Nonsteroidal Anti-Inflammatory (51 Int. Cl. .................. A61K 31/44 Drugs, pp. 111-252 (1985). 52 U.S. Cl. ............ 514/356; 514/355 Ward, Am. J. Med., pp. 3-9 (1984). Triggle and Janis, Structure and Physiology if the Slow (58) Field of Search ...................................... 514/355, 356 Inward Calcium Channel, pp. 51-70 (1987). (56) References Cited Godfraind et al., Pharmacol. Rev. 38, 321-416 (1986). Janis and Triggle, Drug Dev. Res. 4, 257-274 (1984). U.S. PATENT DOCUMENTS Schramm et al., Nature 303, 535-537 (1983). Re. 33,963 6/1992 Hegasy ......... ... 424/78.24 Scriabine, Rational Drug Therapy 21, 1-17 (1987). 3,932,645 1/1976 Meyer et al. ........................... 424/266 Chen et al., Science 239, 1024 (1988). 4,154,839 5/1979 Wehinger et al.
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