Available online at http://www.ifgdg.org Int. J. Biol. Chem. Sci. 13(4): 1918-1937, August 2019 ISSN 1997-342X (Online), ISSN 1991-8631 (Print) Original Paper http://ajol.info/index.php/ijbcs http://indexmedicus.afro.who.int Ghanaian Mangrove Wetland Endophytic Fungus, Penicillium herquei strain BRS2A-AR produces (9Z, 11E)-13-oxooctadeca-9,11-dienoic acid with activity against Trichomonas mobilensis Kennedy HAYIBOR1, Samuel KWAIN1, Enoch OSEI1, Adwoa Padiki NARTEY1, Gilbert Mawuli TETEVI1, Kofi Baffour-Awuah OWUSU2, Mustafa CAMAS3, Anil Sazak CAMAS3 and Kwaku KYEREMEH1* 1 Marine and Plant Research Laboratory of Ghana, Department of Chemistry, School of Physical and Mathematical Sciences, University of Ghana, P.O. Box LG 56, Legon-Accra, Ghana. 2 Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box LG 581, Legon-Accra, Ghana. 3 Department of Bioengineering, Munzur University, 62000 Tunceli, Turkey. *Corresponding author; E-mail:
[email protected]; Tel.: +233-50-482-9778 ABSTRACT Sub-Sahara Africa is burdened with a high incidence of parasitic infections, including schistosomiasis, trypanosomiasis, trichomoniasis, and leishmaniasis. Currently, there is a rapid widespread development of resistance to prescription drugs for these neglected diseases. Microbes provide the largest chemical and biological diversity in drug discovery screening programs; therefore, our project seeks to explore microbes in the sub-region for new drugs. The oxylipin (9Z,11E)-13-oxooctadeca-9,11-dienoic acid (1) was isolated from the Ghanaian endophytic fungus, Penicillium herquei strain BRS2A-AR obtained from the leaves of a Laguncularia racemosa tree growing on the banks of the River Butre in the Western Regional wetlands of Ghana.