bioRxiv preprint doi: https://doi.org/10.1101/547026; this version posted February 13, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 2 The Telomerase Reverse Transcriptase (TERT) and p53 Regulate Mammalian PNS and 3 CNS Axon Regeneration downstream of c-Myc 4 5 Jin-Jin Ma1#, Ren-Jie Xu2,3#, Xin Ju2#, Wei-Hua Wang1, Zong-Ping Luo1,2, Chang-Mei Liu4,5, Lei 6 Yang1,2, Bin Li1,2, Jian-Quan Chen1,2, Bin Meng2, Hui-Lin Yang1,2, Feng-Quan Zhou6, 7* and 7 Saijilafu1,2* 8 9 1Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China 10 2Department of Orthopaedic Surgery, the First Affiliated Hospital, Soochow University, Suzhou, 11 China 12 3Department of Orthopaedics, Suzhou Municipal Hospital/the Affiliated Hospital of Nanjing 13 Medical University, Suzhou, Jiangsu, China 14 4State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese 15 Academy of Science, Beijing, China 16 5Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China 17 6Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, 18 MD, USA. 19 7The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of 20 Medicine, Baltimore, MD, USA. 21 22 # These authors contributed equally to this work 23 24 *Correspondence: Saijilafu, MD, Ph.D.;Feng-Quan Zhou, Ph.D. 25 Phone: 0512-6778-0762 26 Email:
[email protected];
[email protected] 27 28 29 Running title: The c-Myc / TERT / p53 Pathways regulates axon growth 30 31 32 33 34 bioRxiv preprint doi: https://doi.org/10.1101/547026; this version posted February 13, 2019.