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Evolutionary Relationships and Systematics of the Alphaviruses ANN M
JOURNAL OF VIROLOGY, Nov. 2001, p. 10118–10131 Vol. 75, No. 21 0022-538X/01/$04.00ϩ0 DOI: 10.1128/JVI.75.21.10118–10131.2001 Copyright © 2001, American Society for Microbiology. All Rights Reserved. Evolutionary Relationships and Systematics of the Alphaviruses ANN M. POWERS,1,2† AARON C. BRAULT,1† YUKIO SHIRAKO,3‡ ELLEN G. STRAUSS,3 1 3 1 WENLI KANG, JAMES H. STRAUSS, AND SCOTT C. WEAVER * Department of Pathology and Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555-06091; Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado2; and Division of Biology, California Institute of Technology, Pasadena, California 911253 Received 1 May 2001/Accepted 8 August 2001 Partial E1 envelope glycoprotein gene sequences and complete structural polyprotein sequences were used to compare divergence and construct phylogenetic trees for the genus Alphavirus. Tree topologies indicated that the mosquito-borne alphaviruses could have arisen in either the Old or the New World, with at least two transoceanic introductions to account for their current distribution. The time frame for alphavirus diversifi- cation could not be estimated because maximum-likelihood analyses indicated that the nucleotide substitution rate varies considerably across sites within the genome. While most trees showed evolutionary relationships consistent with current antigenic complexes and species, several changes to the current classification are proposed. The recently identified fish alphaviruses salmon pancreas disease virus and sleeping disease virus appear to be variants or subtypes of a new alphavirus species. Southern elephant seal virus is also a new alphavirus distantly related to all of the others analyzed. -
Diapositiva 1
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Diposit Digital de Documents de la UAB Annabel García León, Faculty of Biosciences, Microbiology degree Universitat Autònoma de Barcelona, 2013 EMERGING ARBOVIRAL DISEASES GLOBAL WARMING In the past 50 years, many vector-borne diseases have The accumulation of greenhouse gases (GHG) in the atmosphere by human activity altered emerged. Some of these diseases are produced for exotic the balance of radiation of the atmosphere, altering the TEMPERATURE at the Earth's surface pathogens that have been introduced into new regions and [1]. others are endemic species that have increased in incidence or have started to infect the human populations for first time Growth human Some longwaves ↑ Air Temperature (new pathogens). population Accumulation of radiation from the Near Surface Many of these vector-borne diseases are caused by greenhouse gases sun are absorbed ↑ Specific Humidity arbovirus. Arboviruses are virus transmitted by arthropods in the atmosphere and re-emitted to ↑ Ocean Heat Content vectors, such mosquitoes, ticks or sanflys. The virus is usually (burn fuels in the Earth by GHG ↑ Sea Level electricity generation, transmitted to the vector by a blood meal, after replicates in Increased per molecules ↑ Sea-Surface transport, industry, capita Temperature the vector salivary glands, where it will be transmitted to a agriculture and land consumption other animal upon feeding. Thus, the virus is amplified by use change, use of ↑ Temperature over of resources fluorinated gases in the oceans the vector and without it, the arbovirus can’t spread. (water, energy, industry) ↑ Temperature over In 1991, Robert Shope, presented the hypothesis that material, land, the land global warming might result in a worldwide increase of biodiversity) ↓ Snow Cover zoonotic infectious diseases. -
Characterizing the Fecal Shedding of Swine Infected with Japanese Encephalitis Virus
Characterizing the fecal shedding of swine infected with Japanese encephalitis virus by Konner Cool B.S., Kansas State University, 2017 A REPORT submitted in partial fulfillment of the requirements for the degree MASTER OF SCIENCE Department of Diagnostic Medicine/Pathobiology College of Veterinary Medicine KANSAS STATE UNIVERSITY Manhattan, Kansas 2020 Approved by: Major Professor Dr. Dana Vanlandingham Copyright © Konner Cool 2020. Abstract Japanese encephalitis virus (JEV) is an enveloped, single-stranded, positive sense Flavivirus with five circulating genotypes (GI to GV). JEV has a well described enzootic cycle in endemic regions between swine and avian populations as amplification hosts and Culex species mosquitoes which act as the primary vector. Humans are incidental hosts with no known contributions to sustaining transmission cycles in nature. Vector-free routes of JEV transmission have been described through oronasal shedding of viruses among infected swine. The aim of this study was to characterize the fecal shedding of JEV from intradermally challenged swine. The objective of the study was to advance our understanding of how JEV transmission can be maintained in the absence of arthropod vectors. Our hypothesis is that JEV RNA will be detected in fecal swabs and resemble the shedding profile observed in swine oral fluids, peaking between days three and five. In this study fecal swabs were collected throughout a 28-day JEV challenge experiment in swine and samples were analyzed using reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). Quantification of viral loads in fecal shedding will provide a more complete understanding of the potential host-host transmission in susceptible swine populations. -
Science Article: If the Mercury Soars, So May Health Hazards
If the Mercury Soars, So May Health Hazards Richard Stone Science, New Series, Vol. 267, No. 5200. (Feb. 17, 1995), pp. 957-958. Stable URL: http://links.jstor.org/sici?sici=0036-8075%2819950217%293%3A267%3A5200%3C957%3AITMSSM%3E2.0.CO%3B2-0 Science is currently published by American Association for the Advancement of Science. Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available at http://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact information may be obtained at http://www.jstor.org/journals/aaas.html. Each copy of any part of a JSTOR transmission must contain the same copyright notice that appears on the screen or printed page of such transmission. The JSTOR Archive is a trusted digital repository providing for long-term preservation and access to leading academic journals and scholarly literature from around the world. The Archive is supported by libraries, scholarly societies, publishers, and foundations. It is an initiative of JSTOR, a not-for-profit organization with a mission to help the scholarly community take advantage of advances in technology. For more information regarding JSTOR, please contact [email protected]. http://www.jstor.org Sun Jul 1 18:16:11 2007 I MALARlA RISK. -
Libros Sobre Enfermedades Autoinmunes: Tratamientos, Tipos Y Diagnósticos- Profesor Dr
- LIBROS SOBRE ENFERMEDADES AUTOINMUNES: TRATAMIENTOS, TIPOS Y DIAGNÓSTICOS- PROFESOR DR. ENRIQUE BARMAIMON- 9 TOMOS- AÑO 2020.1- TOMO VI- - LIBROS SOBRE ENFERMEDADES AUTOINMUNES: TRATAMIENTOS, TIPOS Y DIAGNÓSTICOS . AUTOR: PROFESOR DR. ENRIQUE BARMAIMON.- - Doctor en Medicina.- - Cátedras de: - Anestesiología - Cuidados Intensivos - Neuroanatomía - Neurofisiología - Psicofisiología - Neuropsicología. - 9 TOMOS - - TOMO VI - -AÑO 2020- 1ª Edición Virtual: (.2020. 1)- - MONTEVIDEO, URUGUAY. 1 - LIBROS SOBRE ENFERMEDADES AUTOINMUNES: TRATAMIENTOS, TIPOS Y DIAGNÓSTICOS- PROFESOR DR. ENRIQUE BARMAIMON- 9 TOMOS- AÑO 2020.1- TOMO VI- - Queda terminantemente prohibido reproducir este libro en forma escrita y virtual, total o parcialmente, por cualquier medio, sin la autorización previa del autor. -Derechos reservados. 1ª Edición. Año 2020. Impresión [email protected]. - email: [email protected].; y [email protected]; -Montevideo, 15 de enero de 2020. - BIBLIOTECA VIRTUAL DE SALUD del S. M.U. del URUGUAY; y BIBLIOTECA DEL COLEGIO MÉDICO DEL URUGUAY. 0 0 0 0 0 0 0 0. 2 - LIBROS SOBRE ENFERMEDADES AUTOINMUNES: TRATAMIENTOS, TIPOS Y DIAGNÓSTICOS- PROFESOR DR. ENRIQUE BARMAIMON- 9 TOMOS- AÑO 2020.1- TOMO VI- - TOMO V I - 3 - LIBROS SOBRE ENFERMEDADES AUTOINMUNES: TRATAMIENTOS, TIPOS Y DIAGNÓSTICOS- PROFESOR DR. ENRIQUE BARMAIMON- 9 TOMOS- AÑO 2020.1- TOMO VI- - ÍNDICE.- - TOMO I . - - ÍNDICE. - PRÓLOGO.- - INTRODUCCIÓN. - CAPÍTULO I: -1)- GENERALIDADES. -1.1)- DEFINICIÓN. -1.2)- CAUSAS Y FACTORES DE RIESGO. -1.2.1)- FACTORES EMOCIONALES. -1.2.2)- FACTORES AMBIENTALES. -1.2.3)- FACTORES GENÉTICOS. -1.3)- Enterarse aquí, como las 10 Tipos de semillas pueden mejorar la salud. - 1.4)- TIPOS DE TRATAMIENTO DE ENFERMEDADES AUTOINMUNES. -1.4.1)- Remedios Naturales. -1.4.1.1)- Mejorar la Dieta. -
Ribofuranosylselenazole-4-Carboxamide, a New Antiviral Agentt JORMA J
ANTiMICROBIAL AGENTS AND CHEMOTHERAPY, Sept. 1983, P. 353-361 Vol. 24, No. 3 0066-4804/83/090353-09$02.00/0 Copyright 0 1983, American Society for Microbiology Broad-Spectrum Antiviral Activity of 2-p-D- Ribofuranosylselenazole-4-Carboxamide, a New Antiviral Agentt JORMA J. KIRSI,'* JAMES A. NORTH,1 PATRICIA A. McKERNAN,1 BYRON K. MURRAY,2 PETER G. CANONICO,3 JOHN W. HUGGINS,3 PREM C. SRIVASTAVA,4 AND ROLAND K. ROBINS5 Department ofMicrobiology1 and Cancer Research Center, Department of Chemistry,5 Brigham Young University, Provo, Utah 84602; Department ofMicrobiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 232982; Department ofAntiviral Studies, U.S. Army Medical Research Institute ofInfectious Diseases, Fort Detrick, Frederick, Maryland 217103; and Health and Safety Research Division (Nuclear Medicine Technology Group), Oak Ridge National Laboratory, Oak Ridge, Tennessee 378304 Received 7 February 1983/Accepted 13 June 1983 The relative in vitro antiviral activities of three related nucleoside carboxam- ides, ribavirin (1-3-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin (2- 3-D-ribofuranosylthiazole-4-carboxamide), and selenazole (2-p-D-ribofuranosyl- selenazole-4-carboxamide), were studied against selected DNA and RNA viruses. Although the activity of selenazole against different viruses varied, it was significantly more potent than ribavirin and tiazofurin against all tested represen- tatives of the families Paramyxoviridae (parainfluenza virus type 3, mumps virus, measles virus), Reoviridae (reovirus type 3), Poxviridae (vaccinia virus), Herpes- viridae (herpes simplex virus types 1 and 2), Togaviridae (Venezuelan equine encephalomyelitis virus, yellow fever virus, Japanese encephalitis virus), Bunya- viridae (Rift Valley fever virus, sandfly fever virus [strain Sicilian], Korean hemorrhagic fever virus), Arenaviridae (Pichinde virus), Picornaviridae (coxsack- ieviruses B1 and B4, echovirus type 6, encephalomyocarditis virus), Adenoviri- dae (adenovirus type 2), and Rhabdoviridae (vesicular stomatitis virus). -
A Deadly Virus Escapes
EBSCOhost http://web3.epnet.com/delivery.asp?_ ug=dbs+7%2C8o/o2C20+ln+en ... 2 page(s) will be printed. Record: 58 Title: A deadly virus escapes. Subject(s): MEDICAL laboratories- Accidents; COMMUNICABLE diseases -Transmission; YALE University (New Haven, Conn.).- Arbovirus Research Unit; CONNECTICUT; NEW Haven (Conn.) Source: Time, 9/5194, Vol. 1441ssue 10, p63, 1p, 2c Author(s): Lemonick, Michael D.; Park, Alice Abstract: States that concerns about lab security have arisen after a mysterious disease from Brazil struck a researcher at the Yale Arbovirus Research Unit. How the unnamed researcher became infected with the Sabia virus; Exposure of others before his illness was stopped. AN: 9408317724 ISSN: 0040-781X Full Text Word Count: 989 Database: Academic Search Premier MEDICINE A DEADLY VIRUS ESCAPES Concerns about lab security arise as a mysterious disease from Brazil strikes a Yale researcher The accident must have come as a horrifying shock, even for an experienced scientist. One minute, a sample was spinning in a high-speed centrifuge. Then, suddenly, the container cracked, and the sample - tissue contaminated by a rare, potentially lethal virus- spattered the inside of the centrifuge. Fortunately, the Yale University researcher working with the deadly germs was wearing a lab gown, latex gloves and a mask, as required under federal guidelines. He also knew the proper procedure for dealing with a deadly spill: rub every surface with bleach, sterilize all instruments that have been exposed, then wipe everything down again with alcohol. There was just one rule he failed to follow. Having decided the danger was over, he didn't bother to report the accident, and a few days later he left town to visit an old friend in Boston. -
NIAID Biodefense Research Agenda for CDC Category B and C Priority
BIODEFENSE NIAID Biodefense Research Agenda for Category B and C Priority Pathogens January 2003 U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases NIAID Biodefense Research Agenda for Category B and C Priority Pathogens January 2003 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases NIH Publication No. 03-5315 January 2003 http://biodefense.niaid.nih.gov THE NIAID BIODEFENSE RESEARCH AGENDA FOR CATEGORY B AND CPRIORITY PATHOGENS TABLE OF CONTENTS PAGE V PREFACE 1 1 INTRODUCTION 2 2 AREAS OF RESEARCH EMPHASIS 3 3 GENERAL RECOMMENDATIONS 5 4 INHALATIONAL BACTERIA 7 5 ARTHROPOD-BORNE VIRUSES 14 6 TOXINS 20 7 FOOD- AND WATER-BORNE PATHOGENS 25 BACTERIA VIRUSES PROTOZOA 8 EMERGING INFECTIOUS DISEASES 43 INFLUENZA MULTI-DRUG RESISTANT TUBERCULOSIS 9 ADDITIONAL BIODEFENSE CONSIDERATIONS 50 APPENDIX 1 NIAID CATEGORY A, B, AND C PRIORITY PATHOGENS APPENDIX 2 CDC BIOLOGICAL DISEASES/AGENTS LIST APPENDIX 3 LIST OF PARTICIPANTS i THE NIAID BIODEFENSE RESEARCH AGENDA FOR CATEGORY B AND CPRIORITY PATHOGENS PREFACE On October 22 and 23, 2002, the National Institute of Allergy and Infectious Diseases (NIAID) convened a Blue Ribbon Panel on Biodefense and Its Implications for Biomedical Research. This panel of experts was brought together to provide objective expertise on the Institute’s future biodefense research agenda, as it relates to the NIAID Category B and C Priority Pathogens (Appendix 1). This Blue Ribbon Panel was asked to provide NIAID with the following guidance: � Assess the current research sponsored by NIAID related to the development of effective measures to counter the health consequences of bioterrorism with a focus on the Category B and C priority pathogens. -
Thèse Coccidiose Du Poulet
اجلمهورية اجلزائرية الدميقراطية الشعبية République Algérienne Démocratique et Populaire وزارة التعليم العايل والبحث العلمي Ministère de l’Enseignement Supérieur et de la Recherche Scientifique Université Constantine 1 جامعة قسنطينة Institut des Sciences Vétérinaires 1 معهد العلوم البيطرية Thèse Présentée en vue de l’obtention du Doctorat en Sciences Vétérinaires Option : Pathologie aviaire Coccidiose du poulet : Etude pharmacologique et immunologique Présentée Par : DJEMAI Samir Membres du jury : Gamma 횪 휸 Omicron 횶 흄 Président BENCHEIKH ELFEGOUN Professeur Université de Constantine Mohammed Chérif Examinateur BENAKHLA Ahmed Professeur Université d’El-Tarf Examinateur AISSI Meriem Professeur École Nationale Supérieure Vétérinaire- Alger Examinateur ALLOUI Nadir Professeur Université de Batna Directeur de thèse MEKROUD Abdeslam Professeur Université de Constantine Année universitaire : 2016 / 2017 قَا َل َر ُسو َل ا ه َِّلل َص هَّل ا ه َُّلل عَلَْي ِه َو َس هَّل :« اللههُ هم انْ َف ْعِِن ِب َما عَله ْمتَِِن، َوعَِل ْمِِن َما يَْن َف ُعِِن، َوا ْرُز ْقِِن ِعلْ ًما تَ ْن َف ُعِِن ِب ِه » . ]السلسةل الصحيحة-حديث رمق 3151- ا أللباين[. Le Prophète- Que la prière d'Allah et Son salut soient sur lui- disait : « Ô Allah ! Fais- moi profiter de ce que Tu m’as appris, Apprends-moi ce qui m’apporte bénéfice et Accorde-moi une science par laquelle Tu Vas me faire profiter ». [Silsila Sahiha n°3151-Cheikh Al-Albani]. Prophet Muhammad-Peace be upon him- said : « Oh Allah ! Make useful for me what you have taught me, (and) teach me knowledge that will be useful to me and grant me such knowledge that will benefit me ». [Silsila Sahiha n°3151-Cheikh Al-Albani]. -
Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept
pathogens Article Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept Ravendra P. Chauhan 1 , Zelalem G. Dessie 2,3 , Ayman Noreddin 4,5 and Mohamed E. El Zowalaty 4,6,7,* 1 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa; [email protected] 2 School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban 4001, South Africa; [email protected] 3 Department of Statistics, College of Science, Bahir Dar University, Bahir Dar 6000, Ethiopia 4 Infectious Diseases and Anti-Infective Therapy Research Group, Sharjah Medical Research Institute and College of Pharmacy, University of Sharjah, Sharjah 27272, UAE; [email protected] 5 Department of Medicine, School of Medicine, University of California, Irvine, CA 92868, USA 6 Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75185 Uppsala, Sweden 7 Division of Virology, Department of Infectious Diseases and St. Jude Center of Excellence for Influenza Research and Surveillance (CEIRS), St Jude Children Research Hospital, Memphis, TN 38105, USA * Correspondence: [email protected] Received: 17 February 2020; Accepted: 7 April 2020; Published: 20 April 2020 Abstract: Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. -
Life, Not Itself: Inanimacy and the Limits of Biology
Life, Not Itself: Inanimacy and the Limits of Biology The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Roosth, Sophia. 2014. “Life, Not Itself: Inanimacy and the Limits of Biology.” Grey Room 57 (October): 56–81. doi:10.1162/grey_a_00156. Published Version doi:10.1162/GREY_a_00156 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:14023015 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Ernst Haeckel. Bathybius haeckelii . Plate 17 from “ Beitrage zur Plastidentheorie,” Jenaische Zeitschrift für Medizin und Naturwissenschaft , vol. 5, 1870. 56 doi:10.1162/GREY_a_00156 Life, Not Itself: Inanimacy and the Limits of Biology SOPHIA ROOSTH Origins: Mud and Slime Something that for three months had looked like a rock got up and moved about a foot, then settled down again and looked like a rock for three more months. Another rocklike thing sprouted an arm and waved it about for twelve hours, then remained motionless for the rest of the six months. Life proceeds without haste in the deep. So the New York Times reported on time-lapse photographers seeking valuable minerals on the Pacific seafloor in 1977. 1 How quickly must life proceed to count as life? What defines life when the animating processes that mark the living slow into imperceptibility, as life deanimates, slackening or pausing from the temporalities of biological phenomena into epochs geological? Such an uncanny discovery, made possible by the temporal disruptions of stop-motion photography, tests the limits of the organic and the inorganic, the living and the lifeless, in the silty beds of a salty sea. -
The Signal Peptide of the Junín Arenavirus Envelope Glycoprotein Is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex
University of Montana ScholarWorks at University of Montana Biological Sciences Faculty Publications Biological Sciences 10-2004 The Signal Peptide of the Junín Arenavirus Envelope Glycoprotein is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex Joanne York Victor Romanowski Min Lu Jack H. Nunberg University of Montana - Missoula, [email protected] Follow this and additional works at: https://scholarworks.umt.edu/biosci_pubs Part of the Biology Commons Let us know how access to this document benefits ou.y Recommended Citation York, Joanne; Romanowski, Victor; Lu, Min; and Nunberg, Jack H., "The Signal Peptide of the Junín Arenavirus Envelope Glycoprotein is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex" (2004). Biological Sciences Faculty Publications. 147. https://scholarworks.umt.edu/biosci_pubs/147 This Article is brought to you for free and open access by the Biological Sciences at ScholarWorks at University of Montana. It has been accepted for inclusion in Biological Sciences Faculty Publications by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact [email protected]. JOURNAL OF VIROLOGY, Oct. 2004, p. 10783–10792 Vol. 78, No. 19 0022-538X/04/$08.00ϩ0 DOI: 10.1128/JVI.78.19.10783–10792.2004 Copyright © 2004, American Society for Microbiology. All Rights Reserved. The Signal Peptide of the Junín Arenavirus Envelope Glycoprotein Is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex Joanne York,1