From mycelium to spores: A whole circle of biological potency of mosaic Puffball P. P. Petrović a, J. Vunduk b, A. Klaus b, M. Carević c, M. Petković d, N. Vuković e, A. Cvetković e, Ž. Žižak f, B. Bugarski g, Petrović a, J. Vunduk b, A. Klaus b, M. Carević c, M. Petković d, N. Vuković e, A. Cvetković e, Ž. Žižak f, B. Bugarski g Affiliations a Innovation Center of the Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11060 Belgrade, Serbia b Institute for Food Technology and Biochemistry, University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11080 Belgrade, Serbia c Department of Biochemical Engineering and Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11060 Belgrade, Serbia d Department of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia e Laboratory for Gas Chromatography, Institute for Public Health of Belgrade, Bulevar despota Stefana 54A, 11000 Belgrade, Serbia f Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia g Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11060 Belgrade, Serbia Keywords: Mushrooms, Mosaic puffball, Handkea utriformis, Tyrosinase inhibition, Acetylcholinesterase inhibition, HMG-CoA reductase inhibition, Antimicrobial, Antioxidant, Ergosterol, Lovastatin ____________________________________________________________________ Corresponding author: E-mail address:
[email protected] (P. Petrović) 1 Abstract Methanol extracts of mosaic puffball (Handkea utriformis, Bovistella utriformis, Lycoperdon utriforme, Calvatia utriformis – current name is a subject of debate), from three different stages – mycelium (HUMIC), immature (HUI) and mature fruiting bodies (HUM) were characterized and tested for antioxidant, antimicrobial and inhibitory activity on tyrosinase, acetyholinesterase (AChE), butyrylcholinesterase (BuChE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA-R).