Hypnotics and Their Uses
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Nietzsche and Psychedelics – Peter Sjöstedt-H –
Antichrist Psychonaut: Nietzsche and Psychedelics – Peter Sjöstedt-H – ‘… And close your eyes with holy dread, For he on honey-dew hath fed, And drunk the milk of Paradise.’ So ends the famous fragment of Kubla Khan by the Romantic poet, Samuel Taylor Coleridge. He tells us that the poem was an immediate transcription of an opium-induced dream he experienced in 1797. As is known, the Romantic poets and their kin were inspired by the use of psychoactive substances such as opium, the old world’s common pain reliever. Pain elimination is its negative advantage, but its positive attribute lies in the psychedelic (‘mind- revealing’)1 state it can engender – a state described no better than by the original English opium eater himself, Thomas De Quincey: O just and righteous opium! … thou bildest upon the bosom of darkness, out of the fantastic imagery of the brain, cities and temples, beyond the art of Phidias and Praxiteles – beyond the splendours of Babylon and Hekatómpylos; and, “from the anarchy of dreaming sleep,” callest into sunny light the faces of long-buried beauties … thou hast the keys of Paradise, O just, subtle, and mighty opium!2 Two decades following the publication of these words the First Opium War commences (1839) in which China is martially punished for trying to hinder the British trade of opium to the Chinese people. Though opium, derived from the innocent garden poppy Papavar somniferum, may cradle the keys to Paradise it also clutches the keys to Perdition: its addictive thus potentially ruinous nature is commonly known. Today, partly for these reasons, opiates are mostly illegal without license – stringently so in their most potent forms of morphine and heroin. -
Comparison of Intranasal Versus Intravenous Midazolam for Management of Status Epilepticus in Dogs: a Multi-Center Randomized Parallel Group Clinical Study
Received: 16 July 2019 Accepted: 9 September 2019 DOI: 10.1111/jvim.15627 STANDARD ARTICLE Comparison of intranasal versus intravenous midazolam for management of status epilepticus in dogs: A multi-center randomized parallel group clinical study Marios Charalambous1 | Holger A. Volk2 | Andrea Tipold2 | Johannes Erath2 | Enrice Huenerfauth2 | Antonella Gallucci3 | Gualtiero Gandini3 | Daisuke Hasegawa4 | Theresa Pancotto5 | John H. Rossmeisl5 | Simon Platt6 | Luisa De Risio7 | Joan R. Coates8 | Mihai Musteata9 | Federica Tirrito10 | Francesca Cozzi10 | Laura Porcarelli11 | Daniele Corlazzoli11 | Rodolfo Cappello12 | An Vanhaesebrouck13 | Bart J.G. Broeckx14 | Luc Van Ham1 | Sofie F.M. Bhatti1 1Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium 2Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany 3Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy 4Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan 5Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia 6Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 7Small Animal Referral Centre, Animal Health Trust, Newmarket, United Kingdom 8Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 9Department of Clinical Veterinary -
ANNNNNNNNNNNNNNNNNNNN 100A 006 Left Eye Input Right Eye Input
US 20190175049A1 ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2019 /0175049 A1 Welling ( 43 ) Pub . Date : Jun . 13 , 2019 ( 54 ) TECHNIQUES FOR ANALYZING (52 ) U . S . CI. NON -VERBAL MARKERS OF CONDITIONS CPC . .. A61B 5 /04842 (2013 . 01 ) ; A61B 5 / 7289 USING ELECTROPHYSIOLOGICAL DATA (2013 . 01) ; A61B 5 /0478 ( 2013 .01 ) ; A61B 5 /7225 ( 2013. 01 ) ; G06N 20 / 10 (2019 .01 ) (71 ) Applicant: Massachusetts Institute of Technology , Cambridge , MA (US ) ( 57 ) ABSTRACT (72 ) Inventor : Caroline Welling, Hanover, NH (US ) Embodiments related to analyzing brain activity of a subject to identify signs associated with binocular rivalry . Sensed ( 21 ) Appl. No. : 16 / 206, 639 electrical activity of a subject' s brain is received over a time period while the subject is exposed to a visual stimulus. The ( 22 ) Filed : Nov. 30 , 2018 sensed electrical activity comprises a first frequency band Related U . S . Application Data associated with a first frequency of a first image presented to the subject ' s left eye , a second frequency band associated (60 ) Provisional application No .62 / 593 , 535, filed on Dec . with a second frequency of a second image presented to the 1 , 2017 subject ' s right eye . A set of events in the time period is determined based on the frequency bands, wherein an event Publication Classification is associated with a change from a previous perceptual event (51 ) Int. Ci. to a new perceptual event. A metric for the subject is A61B 5 /0484 ( 2006 .01 ) determined based on the set of events . The metric is ana A61B 5 /00 ( 2006 .01 ) lyzed to determine whether the subject exhibits signs asso GO6N 20 / 10 (2006 .01 ) ciated with a condition that is associated with binocular A61B 5 /0478 ( 2006 .01 ) rivalry . -
Sulphonmethane, Sulphonal, Diethylsulpho
is a combination of amylene hydrate and chloral hydrate, superior to the corresponding compounds of other elements. while chloralose, a combination of chloral hydrate and glucose, Experience has shown that, in the main, these claims were un- partakes of the action of morphin and is rather expensive. founded, though many, even now, claim that strontium bro- Chloretone, a more recent product, is not entirely devoid of mid disturbs the stomach less than the corresponding sodium danger and is not always so certain in its action as chloral or potassium salt. Another claim that is frequently made by hydrate, while butyl chloral hydrate, or crotón chloral hydrate, manufacturers of nostrums, like "Peacock's Bromides," is that is one of the older compounds that has been found wanting and they use "chemically pure" salts. Exactly what is meant by is now little used. Of the official compounds of this group we this claim is difficult to say, but the Pharmacopeia gives us a have: number of readily applied tests by which the salts themselves Chloralamid and Paraldehyd. may be tested. The manufacturers of nostrums, on the other Chlobalformamidum.—TJ. S.—Chloralformamid. Chlorala- hand, not infrequently add the very substances that are consid- mid. This has practically the same action as therapeutic ered contaminations. doses of chloral hydrate, the latter being formed in the body by {To be continued.) decomposition of chloralformamid. Average dose: 1 gm. (15 grains). Paraldehtdum.—TJ. S.—Paraldehyd is slower in its action transparent liquid, slower in its action than chloral hydrate, but also safer. It has the disadvantage of a persistently dis- A NEW NEEDLE HOLDER. -
Anesthetic Barbiturates in Refractory Status Epilepticus
LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES Anesthetic Barbiturates in Refractory Status Epilepticus G.B. YOUNG, W.T. BLUME, C.F. BOLTON and K.G. WARREN SUMMARY: Two patients with previous INTRODUCTION hours). With intubation and respiratory cerebral damage and seizures and three Generalized status epilepticus is a support an intravenous bolus of 250 mgms. patients with acute inflammatory cerebral medical emergency requiring prompt thiopental was given, followed by 80-120 lesions developed status epilepticus. They mgm/hr. as a continuous infusion for four treatment to prevent cerebral damage days. The seizures stopped promptly. A were unresponsive to standard anticon or death. Rapidly acting anticonvuls vulsants, but anesthetic barbiturates right-sided hemiparesis resolved over the (thiopental and pentobarbital) stopped the ants such as diazepam, phenytoin or next week and he returned home without seizures promptly. paraldehyde are usually effective. additional neurologicaldeficit. Neurology texts, review articles and Case J. A 41 year old woman developed monographs on epilepsy occasionally measles a week prior to the onset of mention anesthesia for resistant cases. delirium and convulsions. Multi-focal RESUME: Deux patients souffrant pre- Anesthetic barbiturates are less com clonic or grand mal seizures continued for alablement de lesion cerebrate et d'epilepsie two days. These were refractory to et trois patients avec lesions cerebrates de monly specified and their effectiveness is not well documented. We present intravenous phenytoin (a loading dose of nature . inflammatoire aigue developpent 1000 mgm intravenously followed by 200 un status epilepticus. Les patients ne five cases successfully treated with mgm every twelve hours), phenobarbital repondent pas a la medication anticon anesthetic barbiturates after conven (200 mgm intravenous bolus and 60 mgm vulsive standard mais I'emploi de barbitur- tional anticonvulsants failed. -
Disposition of T Oxic Drugs and Chemicals
Disposition of Toxic Drugs and Chemicals in Man, Eleventh Edition Eleventh Edition in Man and Chemicals Drugs Toxic Disposition of The purpose of this work is to present in a single convenient source the current essential information on the disposition of the chemi- cals and drugs most frequently encountered in episodes of human poisoning. The data included relate to the body fluid concentrations of substances in normal or therapeutic situations, concentrations in fluids and tissues in instances of toxicity and the known metabolic fate of these substances in man. Brief mention is made of specific analytical procedures that are applicable to the determination of each substance and its active metabolites in biological specimens. It is expected that such information will be of particular interest and use to toxicologists, pharmacologists, clinical chemists and clinicians who have need either to conduct an analytical search for these materials in specimens of human origin or to interpret 30 Amberwood Parkway analytical data resulting from such a search. Ashland, OH 44805 by Randall C. Baselt, Ph.D. Former Director, Chemical Toxicology Institute Bookmasters Foster City, California HARD BOUND, 7” x 10”, 2500 pp., 2017 ISBN 978-0-692-77499-1 USA Reviewer Comments on the Tenth Edition “...equally useful for clinical scientists and poison information centers and others engaged in practice and research involving drugs.” Y. Caplan, J. Anal. Tox. “...continues to be an invaluable and essential resource for the forensic toxicologist and pathologist.” D. Fuller, SOFT ToxTalk “...has become an essential reference book in many laboratories that deal with clinical or forensic cases of poisoning.” M. -
Rectal Absorption in Childhood
RECTAL ABSORPTION IN CHILDHOOD by JOHN WILLIAM ALEXANDER MACKENZIE, M.B., Ch. THESIS SUBMITTED FOR DEGREE OF M.D. UNIVERSITY OF GLASGOW ProQuest Number: 13849818 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a com plete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 13849818 Published by ProQuest LLC(2019). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106- 1346 (i) CONTENTS Page Preface, ..« «». ••• ••• (ii) Introduction, ... ... ... 1. The Origins of Rectal Therapy, ... 1. The Present Position, ... ... 6. Investigation: A. The Absorption of Glucose, ... 11. Blood Sugar Studies, ... ... 15. The Glucose Content of the Rectal Washout. 18. The Effect of the Glucose Enema on Nitrogen Metabolism, ... ... 19. B. The Absorption of Sodium Chloride, ... 35. C. The Absorption of Predigested Protein, 41. D. The Absorption of Drugs, ... ... 53. 1. Potassium Bromide, ... ... 55. 2. Sodium Salicylate, ... ... 58. 3. Sulphanilamide, ... ... 65. Discussion. The Range of Substances Absorbed, ... 73. The Path of Absorption, ... ... 76. The Quantity Given, ... ... 80. General Conclusion, ... ... ... 84. General Summary, ... ... ... 86. APPENDIX. 1. Solutions used for Rectal Infusion, 87. 2. Biochemical Methods, ... 89. 3. Bibliography, ... ... 94. (ii) PREFACE The work for this thesis was carried out in the wards and biochemical laboratory of the Royal Hospital for Sick Children, Glasgow. -
Chloral Hydrate and Paraldehyde As Drugs of Addiction
Sept., 1932J CHLORAL HYDRATE DRUG HABIT : CHOPRA & SINGH CHOPRA 481 certain parts of the Punjab. This is not the outcome of the use of the drug in the treatment Original Articles of insomnia, but is due to entirely different causes. Until a few years ago in that province potable country-made spirits were allowed to CHLORAL HYDRATE AND PARALDE' be sold to retail dealers in bulk and the vendors HYDE AS DRUGS OF ADDICTION bottled the liquor themselves. Some of these ingenious people conceived the idea of diluting R. N. m.d. By CHOPRA, m.a., (Cantab.) the spirit and adding small quantities of chloral I.M.S. LIEUTENANT-COLONEL, hydrate to make up for the loss in its potency and which would result from dilution. The know- GURBAKHSH SINGH CHOPRA, m.b., b.s. ledge that the drug had hypnotic and narcotic was obtained from the (Drug Addiction Inquiry, Indian Research Fund effects undoubtedly Association) medical profession and compounders work- in It was further learnt that Series No. 15 ing dispensaries. the effects chloral hydrate in many Chloral produced by hydrate and paraldehyde belong to resemble those by alcohol, the of ways produced group drugs known as soporifics or especially when the latter is taken in large The chief use of hypnotics. this class of drugs quantities. When the two articles are taken is in the treatment of one insomnia, of the together they act in a manner synergistic to worst evils of modern times from which man- each other and in this way the effect of either kind can suffer. -
AVMA Guidelines for the Depopulation of Animals: 2019 Edition
AVMA Guidelines for the Depopulation of Animals: 2019 Edition Members of the Panel on Animal Depopulation Steven Leary, DVM, DACLAM (Chair); Fidelis Pharmaceuticals, High Ridge, Missouri Raymond Anthony, PhD (Ethicist); University of Alaska Anchorage, Anchorage, Alaska Sharon Gwaltney-Brant, DVM, PhD, DABVT, DABT (Lead, Companion Animals Working Group); Veterinary Information Network, Mahomet, Illinois Samuel Cartner, DVM, PhD, DACLAM (Lead, Laboratory Animals Working Group); University of Alabama at Birmingham, Birmingham, Alabama Renee Dewell, DVM, MS (Lead, Bovine Working Group); Iowa State University, Ames, Iowa Patrick Webb, DVM (Lead, Swine Working Group); National Pork Board, Des Moines, Iowa Paul J. Plummer, DVM, DACVIM-LA (Lead, Small Ruminant Working Group); Iowa State University, Ames, Iowa Donald E. Hoenig, VMD (Lead, Poultry Working Group); American Humane Association, Belfast, Maine William Moyer, DVM, DACVSMR (Lead, Equine Working Group); Texas A&M University College of Veterinary Medicine, Billings, Montana Stephen A. Smith, DVM, PhD (Lead, Aquatics Working Group); Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia Andrea Goodnight, DVM (Lead, Zoo and Wildlife Working Group); The Living Desert Zoo and Gardens, Palm Desert, California P. Gary Egrie, VMD (nonvoting observing member); USDA APHIS Veterinary Services, Riverdale, Maryland Axel Wolff, DVM, MS (nonvoting observing member); Office of Laboratory Animal Welfare (OLAW), Bethesda, Maryland AVMA Staff Consultants Cia L. Johnson, DVM, MS, MSc; Director, Animal Welfare Division Emily Patterson-Kane, PhD; Animal Welfare Scientist, Animal Welfare Division The following individuals contributed substantively through their participation in the Panel’s Working Groups, and their assistance is sincerely appreciated. Companion Animals—Yvonne Bellay, DVM, MS; Allan Drusys, DVM, MVPHMgt; William Folger, DVM, MS, DABVP; Stephanie Janeczko, DVM, MS, DABVP, CAWA; Ellie Karlsson, DVM, DACLAM; Michael R. -
Rodenticides Snail Baits
SPRING/SUMMER 2018 ISSUE 2018 CPD COURSES Key Areas Covered (six hours of CPD) • Case histories for potential poisons cases • Decontamination for poisons cases • Toxicology information resources • Common or tricky poisonings in cats and dogs Cost and Bookings Standard fee: £295 + VAT Early bird fee: £250 + VAT* Each delegate will receive course notes and a CPD certificate (equates to 6 hours CPD training). Lunch and refreshments are provided. Bookings: To reserve a place, please visit the link below and Welcome download the booking form. https://vpisglobal.com/class- Welcome to the Spring/Summer edition of Toxic Times. based-courses-2018/ Date Location Now that we can put thoughts of ice, snow and travel chaos behind us, it’s time to look ahead to the warmer months, which for many, means May 24th Liverpool gardening and for others, dieting. June 8th Winchester In the garden, we’ll discuss slug bait and Our Key Points to Preventing Poisoning July 19th Glasgow how it is vital that it be kept away from is a reminder and aid to keep our pets safe September 13th London pets and we’ll also look at xylitol, the sugar in the home and garden, and although replacement, and how it too must be kept mostly common sense, is worth reiterating. October 18th Exeter securely away from animals. November 29th Birmingham Finally, the regular update of forthcoming The less commonly seen rodenticide, CPD courses, which this year are proving alphachloralose is also discussed. extremely popular- possibly due in part * Early bird discount applies to bookings made up to 8 weeks prior to the course Case Corner highlights some recent to the provision of homemade cakes. -
INF.20/Rev.1
INF.20/Rev.1 Economic Commission for Europe Inland Transport Committee 17 January 2017 Working Party on the Transport of Dangerous Goods Joint Meeting of Experts on the Regulations annexed to the European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways (ADN) (ADN Safety Committee) Thirteenth session Geneva, 23 - 27 January 2017 Item 5 (b) of the provisional agenda Proposals for amendments to the Regulations annexed to ADN: other proposals Autonome Schutzsysteme Mitteilung von EBU, ESO und ERSTU Ausgangslage Zur 29. Sitzung des Sicherheitsausschusses sind zahlreiche Dokumente vorgelegt worden, die die Anforderungen an Explosionsgruppen für nicht-elektrische Geräte betreffen. Weil es aus Zeitgründen nicht möglich war, im ADN 2017 Änderungen vorzunehmen, hat sich der Sicherheitsausschuss darauf geeinigt, die Probleme in der ersten Phase durch multilaterale Abkommen zu regeln. Hierfür ist das Binnenschifffahrtsgewerbe dankbar. Allerdings verlangt die multilaterale Vereinbarung ADN / M 018 von denjenigen Schiffen, deren Zulassungszeugnis nach dem 31. Dezember 2018 erneuert werden muss, schon sehr bald Maßnahmen, die gründlicher Vorbereitung bedürfen. Aus diesem Grunde ist es erforderlich, sich mit einigen vom Schifffahrtsgewerbe aufgeworfenen Fragen rechtzeitig zu beschäftigen. Frage Im Protokoll der 29. Sitzung des Sicherheitsausschusses ADN/WP.15/AC.2/60 ist unter Ziffer 44. festgehalten worden, dass die informelle Arbeitsgruppe „Stoffe“ mittlerweile um die Prüfung verschiedener Sachverhalte gebeten worden ist. Wie weit sind diese Prüfungen gediehen ? Nachfrage zum Protokolls der 29. Sitzung Im Protokoll der 29. Sitzung des Sicherheitsausschusses ADN/WP.15/AC.2/60 ist unter Ziffer 44. – zweiter Unterpunkt - festgehalten worden, dass das Gewerbe die Arbeitsgruppe Stoffe mit einschlägigen Informationen versorgen müsse. Diese Formulierung des Protokolls bedarf der Nachfrage. -
Alphachloralose Product-Type 14 (Rodenticide)
CA-May08-Doc.3.1a WORKING DOCUMENT: DOES NOT NECESSARILY REPRESENT THE VIEWS OF THE COMMISSION Directive 98/8/EC concerning the placing biocidal products on the market Inclusion of active substances in Annex I or IA to Directive 98/8/EC Assessment Report Alphachloralose Product-type 14 (rodenticide) 30 May 2008 Annex I - PT Alphachloralose (PT 14) Assessment report Finalised in the Standing Committee on Biocidal Products at its meeting on 30 May 2008 in view of its inclusion in Annex I to Directive 98/8/EC CONTENTS 1. STATEMENT OF SUBJECT MATTER AND PURPOSE .................................. 4 1.1. Procedure followed.......................................................................................... 4 1.2. Purpose of the assessment report...................................................................5 1.3. Overall conclusion in the context of Directive 98/8/EC ...............................5 2. OVERALL SUMMARY AND CONCLUSIONS...................................................6 2.1. Presentation of the Active Substance ............................................................6 2.1.1. Identity, Physico-Chemical Properties & Methods of Analysis.......6 2.1.2. Intended Uses and Efficacy ...............................................................7 2.1.3. Classification and Labelling ..............................................................8 2.2. Summary of the Risk Assessment................................................................10 2.2.1. Human Health Risk Assessment......................................................10