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RAG Classification List *please note this list does not include exhaustive information about formulation. Please check formulary website for full details

Name of Drug/Classification Status Comments Abatacept Red Abciximab Red Abiraterone Red Abraxane (Paclitaxel – albumin bound Red formulation) Acamprosate Green Plus Acarbose Green For existing patients only. Unless on for Plus reactive hypoglycaemia on advice of specialist Acetazolamide injection Red Injection: 500 mg vial Acetylcysteine Green Eye drops: acetylcysteine 5%, hypromellose Plus 0.35% (Ilube®) Aciclovir injection (for IV infusion) Red Adalimumab Red Adenosine Red Afatinib Red Aflibercept Red Intravitreal injection: 4 mg/ 0.1mL (dose 2mg/0.05ml) Agomelatine Green Plus Ajmaline injection Red Diagnostic agent Alemtuzumab Red Alfentanil Green Injection: 500 micrograms/1 mL, 5 mg/1 mL Plus Alfentanil Red Injection (amps): 1 mg/2 mL, 5 mg /1 mL Red Hospital use only as paediatric pre- Tablets:10mg medication Syrup: 7.5mg/5ml, 30mg/5ml Alirocumab Red Aliskiren Tablets Green Plus Alpha tocopheryl acetate Green Suspension: 500 mg/5 mL Plus Capsules: 200units (for use in children with cystic fibrosis) Alpha tocopheryl acetate Red Injection: 100mg/2ml (unlicensed) Alprostadil Green Plus Alteplase Red Green plus Amikacin Injection Red Aminophylline Injection Red Infusion Red Amiodarone Tablets Amber

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Amisulpride Green Plus Injection Red Amphotericin Red Amsacrine Red Anagrelide Red Capsules: 500 micrograms (2nd line for ITP and patients at risk of essential thrombocythaemia) Anakinra Red Anastrozole Green Plus Antacid with oxetacaine Green Unlicensed Plus Antithymocyte Immunoglobulin (Rabbit) Red Antithymocyte Immunoglobulin (Horse) Red Amber Red Eye drops: 0.5% Unit dose eye drops: 1% Apremilast Red Aprepitant Red Capsules Aptivus Red Oral solution/capsules (tipranavir) Argatroban Red (tablets and long acting Green injection) Plus Arsenic Trioxide Red Artesunate Red Aspirin dispersible tablets Red For pre-term labor Aspirin suppositories Green 300mg for use in patients following stroke Plus Atezolizumab Red (besylate) Red Amber Atosiban Red Atripla Red Tablets (/emtricitabine/tenofovir) Atropine sulphate Red Avelumab Red Axitinib Red Azacitidine Red Azathioprine Amber Azithromycin Green For COPD indication Plus Aztreonam Red Baricitinib Red BCG Connaught Red Belimumab Red Bendamustine Red Benzathine penicillin Red Benzbromarone Red Unlicensed Benzylpenicillin Red Eye drops: 100,000 units/mL Betamethasone Red For pre-term labor Betamethasone Solution Green Scalp application - As ear drops for eczema

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Plus Betamethasone tablets Green Used as mouth gargle Plus Bevacizumab Red Avastin is available as a treatment option for wet AMD in situations where ophthalmologists feel, in discussion with their patients, that the licensed options are unsuitable Bicalutamide Green Plus Biosimilar infliximab (Inflectra) Red Bivalirudin Red Bismuth and lodoform paste Red Bleomycin Red Blinatumomab Red Boceprevir Red Boric acid Red Bortezomib Red Bosentan Red Bosutinib Red type A Red Brentuximab Red Brivaracetam Green Plus Brodalumab RED Green Plus Bupivacaine hydrochloride Red Buprenorphine Sublingual Tablets Green Sublingual Tablets: 400 micrograms, 2 mg, Plus 8 mg Buprenorphine Sublingual Tablets Red Sublingual Tablets: 200micrograms for the treatment of post-operative pain Buserelin Green Plus Green Plus Busulfan (Busulphan) Red C1-esterase inhibitor Injection (Berinert®) Red Cabazitaxel Red Green Plus Calcitriol Green Capsules: 0.25 micrograms, 0.5 micrograms Plus Calcium chloride Red Injection:10% equivalent to calcium 6.8 mmol/10 mL Calcium Folinate (Folinic Acid) Red Calcium gluconate Red Injection: 10%, equivalent to calcium 2.25 mmol/10 mL Calcium/Magnesium salts Green Tablets: Calcium acetate 435 mg and Plus Magnesium carbonate 235 mg (Osvaren) Canagliflozin Green

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Plus Capecitabine Red Carbamazepine Green Plus Carbon Dioxide (CO2) Red Carboplatin Red Carboprost Red Carfilzomib Red Carmustine Red Caspofungin Red Cefixime Green Plus Ceftazidime Red Ceftolozane and tazobactam (Zerbaxa) Red Cefuroxime Red Celsentri Red Tablets (maraviroc) Ceritinib Red Certolizumab pegol Red Cetuximab Red Chloral Hydrate Red For use in paediatrics only Elixir: 143.3mg/5ml Chlorambucil Red Chloramphenicol Injection Red Chlorhexidine eye drops Red Chorionic gonadotrophin (Ovitrelle, Red Pregnyl) Chorionic gonadotrophin alfa Red Ciclosporin eye drops Green Eye drops: 0.1% Plus Ciclosporin eye drops Red P/F unit dose eye drops: 0.05% Ciclosporin (oral) Amber Ciclosporin (Sandimmun®) Red IV Infusion: 50mg in 1ml & 250mg in 5ml concentrate (oily) Cinacalcet Amber For the treatment of primary hyperparathyrodism Cinacalcet Red For the treatment of secondary hyperparahyrodism Ciprofloxacin IV infusion Red Ciprofloxacin eye drops Red Cisplatin Red Cladribine (Leustat®) Red Clarithromycin Injection Red Clindamycin Injection Red Clobazam Green Plus Clomifene Green Plus Clomiphene Red For ovulation inducation Green Plus

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Clonidine Hydrochloride Ampoules Red Hydrochloride Suspension Red Clonidine Hydrochloride Tablets Green Plus Clopidogrel Green Plus Tablets Red Co-amoxiclav Injection Red Red Cocaine Red P/F eye drops: 4% Co-careldopa with entacapone Green Plus Colesevelam Green Plus Codeine Phosphate Injection Red Colecalciferol Green For bariatric indications Plus (Note: green for non-bariatric indications) Colistimethate sodium Red Collagenase Red Xiapex Combivir Red Tablets (lamivudine/zidovudine) Co-trimoxazole IV infusion Red Crixivan Red Indinavir Crizotinib Red Cyclopentolate hydrochloride with Red Eye drops (preservative free): 1% : Cyclophosphamide Red Cyproterone Acetate 50mg & 100mg Green Indication: Gender Dysphoria, Hirsutism Tablets Plus Cytarabine Red Dabrafenib Red Daclatasvir Red Dacarbazine Red Dactinomycin Red Danaparoid sodium Red Green Capsules: 25 mg, 100 mg Plus Dantrolene sodium Red Injection (vials): 20 mg Dapagliflozin Green Plus Dapsone Amber Daptomycin Green Plus Daratumumab Red Darbepoetin alfa Amber Prefilled syringes: 10, 15, 20,30, 40, 50, 60, 80, 100, 150, 300 micrograms Sureclick pens: 20,40,60,80, 100, 300micrograms Daunorubicin Red Deferasirox Red Degarelix (Firmagon) Green Plus

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Demeclocycline Red Denosumab Amber JFC recommended status changed from Amber to Green Plus at May 2018 meeting. Green Plus leaflet reviewed at June MOGG meeting but was deferred to August meeting as required changes.

Status changed and leaflet published in error on 11.7.18.

Error noted on 16.7.18, Status reverted to amber and Green Plus leaflet removed and replaced with Amber leaflet 16.7.18. Consultants have been informed of this. Descovey Red Tablets (emtricitabine/rilpivirine/tenofovir) note various strengths – see formulary for details Desferrioxamine mesilate Red

Desflurane Red Desmopressin injection Red Desmopressin metered nasal spray Red 150mcg Desmopressin oral lyophilisates Green Noqdirna Plus Desmopressin Green Metered nasal spray: 10 micrograms/spray plus Tablets: 100 micrograms, 200 micrograms Oral lyophilisate: 60 micrograms, 120 micrograms, 240 micrograms and Intranasal solution 100micrograms/1ml Dexamethasone injection Red Dexamethasone Red Intravitreal implant: Dexamfetamine Amber Dexamfetamine Red For use in narcolepsy for doses > 30mg Dexamfetamine Green For use in narcolepsy for doses < 30mg Plus Dexmedetomidine Red Dexrazoxane Red Diaminopyridine Red Diamorphine injection Green Plus Diazoxide Green Plus Diclofenac injection Red Diclofenac sodium Red Eye drops/Unit dose eye drops (preservative-free): 0.1% Diethylstilbestrol (Stilboestrol) Green Plus Dihydrocodeine modified release Green Plus Dimethyl Fumarate Red Dinoprostone Red

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Dipyridamole Green Plus Disodium Edetate Red Disodium pamidronate Red Disopyramide Capsules Green Plus Disopyramide Injection Red Injection Red Docetaxel Red Green Plus hydrochloride Red Dopexamine Red Dornase alfa Red Doxapram Red Doxapram hydrochloride Red Doxorubicin Red Doxycycline Injection Red Dronedarone Amber Dulaglutide Green Plus Green For moderate to severe stress incontinence Plus in combination with supervised pelvic floor excercises Eculizumab Red

Edrophonium chloride Red Hospital use only Edurant Red Tablets (rilpivirine) Eflornithine cream Green Vaniqa Plus Eltrombopag Red

Eluxadoline Green Plus Empagliflozin Green Plus Emtriva Red Capsules and oral solution (emtricabine) Entacapone Green Plus Entecavir Red Entonox (N2O 50% : O2 50%) Red Enzalutamide Red Red Epirubicin Red Epivir Red Tablets and oral solution (lamivudine) Eplerenone Green Epoetin alfa (Eprex) Amber

Epoetin Beta (NeoRecormon) Amber

Epoetin Zeta Amber

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Epoprostenol Red Ergocalciferol Red Injection: 300,000 units/1 mL, 600,000 units/2 mL Red Erlotinib Red Ethambutol 400mg in 5ml unlicensed oral Green liquid Plus Ertapenem Red Erythromycin Red Injection for infusion: 1g vial - for use as a prokinetic Esmolol Red Estradiol (Oestradiol) 1mg & 2mg tablets Green Indication: Gender dysphoria Plus Estradiol twice weekly matrix patches Green Indication: Gender dysphoria releasing approximately 50, 75, Plus 100micrograms/24hours Estradiol 0.1% gel (Sandrena), 0.06% gel Green Indication: Gender dysphoria (Oestrogel) Plus Estramustine Red Etanercept Red Etanercept biosimilar (Benepali) Red Etelcaletide Red Ethambutol Green Plus Ethanol Red Ethosuxamide Green Plus Ethyl chloride Red Spray: 100 mL Etomidate Red Etoposide Red Everolimus (Votubia®) Red Eviplera Red Tablets (emtricitabine/rilpivirine/tenofovir) Evolocumab Red Evotaz Red Tablets (atazanavir/cobicstat) Exemestane Green Plus Exenatide Green Plus Fentanyl sublingual tablets Green Plus Fentanyl nasal spray Green Plus Fentanyl lozenge Green Plus Fentanyl Red Injection: 100 micrograms/2 mL, 500 micrograms/10 mL ampoules Fentanyl with levobupivacaine Red Ferric carboxymaltose (Ferinject®) Red Ferric Maltol (Feraccru) Green

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Plus Fidaxomicin Green Plus Filgrastim Red Finasteride Green Indication: Gender dysphoria, hirsutism Plus Fingolimod Red Flecainide Injection Red Flecainide Tablets Green Plus Flucloxacillin Injection Red Fluconazole IV infusion Red Fludarabine Red Flumazenil Red Fluorescein sodium Red Minims® (preservative free): 1%, 2% Flutamide Green Plus Fluocinolone acetonide Red Fluorometholone eye drops Green Plus Fluorouracil Red Fluribiprofen Red Sunderland Eye Infirmary only Flupenthixol decanoate injection Green Plus Follitrophin alfa Res Gonal F Fondaparinux Injection Red Fuzeon Red Injection (enfuviratide) Green Plus Green Plus Ganciclovir Red IV infusion Ganciclovir eye gel Green Plus Gefitinib Red Gelatin Red Intravenous Infusion Gemcitabine Red Gemeprost Red Gentamicin ear drops Green Plus Gentamicin Red Eye drops: 1.5% Eye drops (preservative free)1.5% Gentamicin Injection Red Glatiramer Red Glecaprevir-pibrentasvir Red Maviret Glucarpidase Red Glyceryl Trinitrate ampoules Red Glyceryl Trinitrate patch Red 5mg, 10mg for hospital use only e.g. vascular access, tendonitis Glyceryl trinitrate spray Red For pre-term labor Glycopyrrronium bromide Red Injection: 200 micrograms/1 mL, 600

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micrograms/3 mL ampoules Glycopyrrronium bromide with neostigmine Red Injection: glycopyrronium 500 microgram & neostigmine 2.5mg in 1ml ampoules Glycopyrrronium bromide Green Suspension*: 2mg/5ml Plus *Only for use in patients with excessive secretions Golimumab Red Gonadorelin Red Goserelin Green Indication: Gender dysphoria Plus Goserelin Amber Grazax Grass pollen extract Amber N.B. for paediatric use only Amber decanoate injection Green Plus Harvoni® (Sofosbuvir with Ledipasvir) Red Heliox21 Red Heparin (note product details in final Red 500 units in sodium chloride 0.9% 500 mL column) infusion bag Hexamidine Red Eye drops: 0.1% Human Albumin Red Hyaluronidase Red Hydralazine Tablets Green Plus Hydralazine Ampoules Red Hydrocortisone MR tablets Green Plus Hydromorphone Ampoules Green Plus Hydroxycarbamide (Hydroxyurea) Red Hydroxychloroquine sulfate Amber MSK indications Hyoscine hydrobromide Green Tablets for paediatric use only Tablets: 150mcg Plus Ampoules: when used for palliative care use Ampoules:400mcg/1ml only Hyoscine hydrobromide Red Ampoules: when used in anaesthetics Ampoules:400mcg/1ml Ibandronic acid Green Plus Ibrutinib Red Icatibant Red Ichthammol glycerine Red Idarubicin Red Idelalisib Red Iloprost Red Unlicensed Imatinib Red Indigocarmin Red Diagnostic agent Indocyanine Green Red Diagnostic agent Infliximab Red Infosfamide Red Insulin Degludec Green Plus

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Intelence Red Tablets (etravirine) Interferon alfa-2b Red Interferon beta-1a Red Interferon beta-1b Red Betaferon Interferon beta-1b Red Extavia Invirase Red Tablets (saqinavir) Iodine (Lugol’s iodine) Red Ipilimumab Red Irinotecan Red Iron isomaltose 1000 (Diafer®) Red

Iron isomaltose 1000 (Monofer®) Red

Isentress Red Tablets (raltegravir) Red Isoniazid Injection Red Isoniazid tablets, 50mg in 5ml unlicensed Green oral liquid Plus Red Injection for infusion 2.25 mg/2 ml vial Isosorbide dinitrate Red Infusion and injection Ixazomib Red Kaletra® Red Tablets (lopinavir + ritonavir) Red Pain/palliative care Ketoconazole HRA Red Ketorolac Red Eye drops: 0.5% Ketorolac trometamol Red For hospice use only Kivexa Red Tablets: abacavir/lamivudine Labetolol Injection Red Lacosamide Green Plus Lamotrigine Green Plus Lanreotide Green Palliative care. RED other indications. Plus Lanreotide Red Acromegaly, neuroendocrine tumour and carcinoid. Lanthanum (Fosrenol) Green Plus Lecicarbon A Red Leflunomide Amber MSK indications Lenalidomide Red Lenograstim Red Lenvatinib Red Letrozole Green Plus Leuprorelin Acetate Green Indication: Gender dysphoria Plus Levetiracetam tablets, oral solution, Green granules Plus Levetiracetam vial Red Levobupicavaine hydrochloride Red

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Levobupicavaine hydrochloride with Red fentanyl Levofloxacin Red Oral tablets as a 12 week prophylaxis for patients with myeloma Lidocaine Infusion Red Lidocaine Red 1% Injection: 5ml, 10ml 2% Injection: 5ml, 20ml Lidocaine hydrochloride cartridges Red Cartridges: lidocaine 1% with 1 in 80,000, 2.2 mL (dental use) Lidocaine hydrochloride with adrenaline Red Injection: lidocaine 1% with adrenaline 1 in (epinephrine) 200,000, 20 mL vials Injection: lidocaine 2% with adrenaline 1 in 200,000, 20 mL vials Lidocaine with adrenaline and tetracaine Red unlicensed Gel: Lidocaine 4% + Adrenaline 0.1% + Tetracaine 0.5% (LAT), 3 mL Lidocaine plasters Green Plasters: 5% (700 mg/plaster) (Versatis®) Plus Lidocaine spray Green 10% Plus Lidocaine topical Red unlicensed Topical: 4%, 50 mL Lidocaine Lolly Green Unlicensed lollies: 100mg Plus Lidocaine with phenylephrine Red unlicensed Nasal spray: Lidocaine 5% with phenylephrine 0.5%, 2.5 mL Lidocaine patches Green Plus Linezolid infusion Red Linezolid tablets, oral solution Green Plus Liothyronine Green Plus Liraglutide Green Plus Amber Lithium carbonate Amber Lithium citrate Amber Lixisenatide Green Plus hydrochloride Green Plus Lomustine Red Injection Green Plus Loteprednol etabonate Green Plus Magnesium sulphate ampoules Red For pre-term labor Magnesium sulfate Red Injection Mannitol Inhalation powder Red Mannitol Intravenous infusion Red Medroxyprogesterone acetate Green For withdrawal bleeding Plus

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Melatonin Amber Indication: sleep-wake disorders in children and young adults under the age of 18 Melatonin Green For the management of sleep-wake Plus disorders in people over the age of 18 and over Melatonin Green Indication: Some sleep disorders (not Plus approved for licensed indication) Melphalan Red Green Plus Mepivacaine hydrochloride Red For dental use Mepolizumab Red Mercaptopurine Red Mercaptopurine Amber GI indications When used for inflammatory bowel disease Meropenem Red Mesna Red Ampoules Red Metformin Red Fertility indications Green Indication: pain and palliative care Plus Methadone Red Indication: substance misuse Methenamine Hippurate Green Plus Methotrexate Red Methotrexate Amber Indication: when used in chronic inflammatory conditions, eg Crohn’s disease, rheumatoid arthritis Methoxy polyethylene glycol-epoetin beta Amber (Mircera®)

Methyldopa Green Plus hydrochloride Amber Methylprednisolone injection Red Injection Red Unless prescribing in end of life care Metolazone Red Metronidazole Injection (for IV infusion) Red injection Red Metoprolol 50mg/5ml oral solution Green Plus Metyrapone Green Plus Mexiletine capsules Green 50mg Plus Midazolam Oromucosal solution Green (Buccolam) Plus Midazolam Red Injection (vials): 2 mg/2 mL, 5 mg/5 mL, 10 mg/2 mL (indications other than palliative care ampoules; 50 mg/50 mL Midazolam Green 10mg2/ml amps when used for palliative

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Plus care tablets 2.5mg, 5mg Green Plus Mifamurtide Red Red Milronone Red Misoprostol Red Mitomycin Green unlicensed Preservative free eye drop: Plus 0.04% preservative free eye drops Mitomycin Red Injection: 10mg, 20mg & 40mg Mitotane Red Mitoxantrone Red Mivacurium Red Moclobemide Green Plus Green Plus Moxifloxacin Red Injection for infusion: 400 mg/250mL Moxonidine Green Plus Mycophenolate Amber Unlicensed for some indications N-Acetylcysteine Solution for nebulisation Green Unlicensed Plus Nabilone Red Naftidrofuryl Green Plus Naloxegol Green Plus Naloxone hydrochloride Red Naltrexone hydrochloride Amber Natalizumab Red Natamycin eye drops Red Neostigmine Green Plus Neostigmine metisulfate (methylsulphate) Red Neostigmine metisulfate (methylsulphate) Red with glycopyrronium Nepafenac Red Eye drops Netupitant and Palonosetron Red Akynzeo Nifedipine Red For pre-term labor Nilotinib Red Nimodipine Red Nintedanib (Vargatef®) Red Nitric Oxide (NO) Red (N2O) Red Nivolumab Red Noradrenaline Red Injection Noradrenaline acid tartrate / Red bitartrate Norethisterone Green For withdrawal bleeding Plus

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Norvir Red Tablets (ritonavir) NuvaRing Green (Vaginal ring releasing ethinylestradiol and Plus etonogestrel) Obinutuzumab Red Ocriplasmin Red Concentration for solution for intravitreal injection: 2.5mg/ml Octreotide Green Palliative care. Red for other indications Plus Octreotide Red Acromegaly, neuroendocrine tumour and carcinoid. Odefsey Red Tablets (emtricitabine/rilpivirine/tenofovir) Ofatumumab Red Ofloxacin IV infusion Red Green Indication: Plus Olaparib Red Olaratumab Red Omalizumab Red Omeprazole infusion Green Plus Ondansetron Injection Red Unless prescribing in end of life care Oral contraceptives for hirsutism Green As per formulary including Co-cyprindol, Plus Lucette tablets Green Plus Oxaliplatin Red Oxybuprocaine hydrochloride (benoxinate) Red Eye drops Oxcarbazepine Tablets Green Plus

Oxygen (O2) Red Oxytocin Red Paclitaxel Red Palbociclib Red injection Green Plus Palonosetron Red Red Panobinostat Red Papavarine hydrochloride Red Parecoxib Red Paraldehyde in olive oil Red Paricalcitol (Zemplar®) Red Patent Blue V Red Diagnostic Patiromer Red Added 28.3.18 Subject to 6 month review Pazopanib Red Pegasparagase Red Peginterferon alfa-2a Red Peginterferon alfa-2b Red Peginterferon beta-1a Red Pembrolizumab Red Pemetrexed Red

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Penicillamine Amber Pentosan Red Perampanel Green Plus Pertuzumab Red Red Pharmalgen Red Phenelzine Green Plus Phenobarbital Green Tablets: 15mg, 30mg, 60mg Plus Elixir: 15mg/5ml Phenobarbital Red Solution (unlicensed) 50mg/5ml Rosemont Hydrochloride Red Phenylbutazone tablets Red For ankylosing spondylitis Phenylephrine hydrochloride Red Ampoules and prefilled syringes Phenytoin Green Plus Phosphate Polyfusor Red Phytomenadione Green Plus Picibanil Red Pilocarpine Green Plus Piperacillin with tazobactam Red palmitate injection Green Plus Pirfenidone Red Newcastle tertiary referral Pixantrone Red Plerixafor Red Polihexanide Red P/F eye drops: 0.02% Eye drops: 0.06% Ponatinib Red Posaconazole Red Poractant Alpha Red Potassium acid phosphate Red Oral solution 1mmol/1ml, 100ml Potassium ascorbate Red Eye drops Potassium chloride Green Modified-release tablets: equivalent to Plus potassium 8 mmol per tablet (Slow-K®) Green Plus Prasugrel Green Plus Prednisolone 25mg tablets (high strength) Green Specialist use only Plus Prednisolone Green Eye drops: 1% (Pred Forte) Plus Prednisolone Injection 25mg/ml Green Deltastab Plus Green Plus Prezista Red Tablets and oral suspension (darunavir)

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Prilocaine hydrochloride Red Prilocaine 2% hyperbaric solution Red Primidone Green Plus Probenecid Green Unlicensed Plus Procarbazine Red Procyclidine Injection Red Propofol Red 1mg/1ml ampoule Red Unlicensed Protamine Red Proterelin Red For use in tertiary referral patients, unlicensed Proxymetacaine hydrochloride Red Minims® eye drops Pyrazinamide including 500mg in 5ml oral Green liquid Plus Pyridostigmine Green Plus Pyridoxine Red Injection Pyridoxine Green Tablets Plus Green Plus Green Plus Radium-223 dichloride Red Ranibizumab Red Ranolazine Green Plus Rasagiline Green Plus Rasburicase Red Commissioned by NHS England Regorafenib Red Remifentanil Red Renavit Green Tablets Plus Reslizumab Red Rezolsta Red Tablets (darunavir/cobicistat) Retigabine Green Plus Retrovir Red Capsules, oral solution and infusion (zidovudine) Reyataz Red Capsules (atazanavir) Ribavirin Red Ribociclib Red

Rifaximin Green Plus Rifampicin capsules, oral syrup Green Indication: TB Plus Rifampicin IV infusion Red

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Rifampicin and isoniazid Green Plus Rifampicin, isoniazid and pyrazinamide Green Plus Riluzole Red (oral preparations and long Green acting injection) Plus Rituximab Red Rivastigmine Green Plus Red Roflumilast Green Plus Romiplostim Red Green Plus Ropivacaine hydrochloride Red Green Plus Ruxolitinib Red Sacubitril / valsartan Green Plus Green Changed from red 28.3.19 Plus Sarilumab Red Secukinumab Red Selenium Red Injection: 100micrograms in 2ml Sevelamer carbonate (Renvela) Green Plus Sevelamer hydrochloride (Renagel) Green Plus Red Sildenafil Red Indication: Pulmonary arterial Tablets: 20mg, 25mg Oral suspension: 10mg/1ml Sildenafil Red For paediatric/hospital use only Liquid: 1mg/1ml Simeprevir Red Sirolimus Amber Sodium aurothiomalate Amber Sodium bicarbonate Red Oral solution: 1mmol/1ml, 100ml

Sodium chloride eye drops Red Unit dose eye drops, Eye drops, Eye ointment, P/F eye drops Sodium chloride Red Oral solution: 1mmol/1ml, 100ml

Sodium citrate Red Sodium Clodronate Green Plus Sodium cromoglicate Green Eye drops (preservative free): 2% Plus

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Sodium fusidate Green Plus Sodium hyaluronate pre-filled syringe Red Hyacyst 120

Sodium hyaluronate pre-filled syringe Red Prefilled syringe (Microvisc): 14mg/ml Prefilled siringe (Provisc): 10mg/ml Healon GV: 14mg/ml Sodium nitroprusside Red Unlicensed Sodium tetradecyl Red Sodium Valproate Injection Red Sodium Valproate – all other formulations Green Plus Sofosbuvir Red Sofosbuvir/velpatasvir/voxilaprevir Red Vosevi Sofrafenib Red Somatropin Red Spironolactone 25mg & 100mg tablets Green Indication: Gender Dysphoria Plus Spironolactone 50mg tablets Green Indication: Hirsutism Plus Spironolactone 25mg/5ml suspension Green Specialist initiation/paediatric use only Plus Streptokinase Red Streptomycin Injection Red Unlicensed Streptozocin Red Stribild Red Tablets (cobicstat/elvitegravir/emtricitabine/tenofovir) Strontium ranelate Green Plus Sulfasalazine Amber For MSK indications Sulfinpyrazone Green Unlicensed Plus Suboxone Green Plus Red Sunitinib Red Sustiva Red Tablets and capsules (efavirenz) Red Syntometrine Red Tacrolimus Amber Injection is red Tadalafil Green For indications involving urinary retention or Plus BPH Talimogene Red Tamoxifen Green Breast cancer Plus Tamoxifen Red Fertility indications Green Plus Tegafur with Uracil (Uftoral®) Red Teicoplanin Red Telaprevir Red

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Telzir Red Tablets and oral solution (fosamprenavir) Temocillin Red Temozolomide Red Tenecteplase Red Tenofovir Red Red For pre-term labor Teriflunomide Red Teriparatide Green Plus Terlipressin Red Testosterone Enantate Green Indication: Gender dysphoria Plus Testosterone esters (Sustanon 250 ®) Green Indication: Gender dysphoria Plus Testosterone Gel Green Indication: Gender dysphoria Plus Testosterone undecanoate Green Indication: Gender dysphoria Plus Green Plus Tetracaine hydrochloride (amethocaine) Red Minims® eye drops Tetracosactide Red Thalidomide Red Thiopental (Thiopentone) sodium Red Thiotepa Red Ticagrelor Green Plus Tinanidine Green Plus Tinidazole Green Plus Tiopronin Red Unlicensed Tigecycline Red Tirofiban Red Tivicay Red Tablets (dolutegravir) Tivozanib Red Tobramycin Red Tocilizumab Red Tofacitinib Red Tolbutamide Green Plus Tolcapone Amber Tolvaptan Red Topiramate Green Plus Topotecan Red Toujeo (high strength insulin glargine Green 300units/ml) Plus Trabectedin Red modified release Green Plus

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Trametinib Red Trastuzumab Red Treosulfan Red Tretinoin Red (Malignant disease and immunosuppression) Triamcinolone/neomycin/gramicidin/nystatin Green (Kenacomb® Otic) Plus Trifluridine & tipiracil Red Trifluorothymidine Red Preservative free eye drops: 1% Triptorelin Green Indication: Precocious puberty Plus Triumeq Red Tablets (dolutegravir/abacavir/lamivudine) Trizivir Red Tablets (lamivudine/abacavir/zidovudine) Truvada Red Tablets (emtricitabine/tenofovir) Tybost Red Tablets (cobicistat) Ulipristal (Esmya®) Red (Red when used for symptoms of uterine fibroids as per MHRA guidance) Ustekinumab Red Urokinase Red Valganciclovir Green Plus Vancomycin capsules Green Plus Vancomycin eye drops Red Vancomycin injection Red Vasopressin Red Red Vedolizumab Red Vemurafenib Red Venetoclax Red Green Doses of more than 300mg are green plus Plus Injection Red Verteporfin Red Videx Red Chewable tablets and E/C capsules (didanosine) Viekirax Red (Ombitasvir/paritaprevir/ritonavir) Vinblastine Red Vincristine Red Vindesine Red Vinorelbine Red Viramune Red Oral suspension, MR tablets, tablets (nevirapine) Viread Red Tablets (tenofovir disoproxil) Vitekta Red Tablets (elvitegravir) Vigabatrin Green Plus Voriconazole Red Zeffix Red Tablets (lamivudine) Zerit Red Capsules and oral solution (stavudine) Ziagen Red Tablets and oral solution (Abacavir)

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Zinc acetate Red Capsules: 25mg Zoledronic acid Red Zonisamide Green Plus acetate injection Red Zuclopenthixol decanoate injection Green Plus

Preparations used in radiology by City Hospitals Sunderland are red. A full list can be viewed via the online Sunderland joint formulary located here. Drugs used as part of CHS resuscitation trollies are red. A full list can be viewed via the online Sunderland joint formulary which is located here. Antidotes stocked by CHS are red. A full list can be viewed via the online Sunderland joint formulary which is located here. Please note, the drugs contained in each of these two categories (resuscitation trollies and antidotes) may have differing RAG status’ for other indications. Please refer to the Sunderland joint formulary website for more information.

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