Broad Institute Fourth Annual Scientific Retreat November 3RD – 4TH | 2008 New Research Building at Harvard Medical School RD Fourth Annual Agenda | November 3 2008 Scientific Retreat 8:15 AM – 9:00 AM Registration and Poster Session I Set-Up November 3RD Breakfast 2008
HMS 9:00 AM – 9:15 AM New Research Building Welcome and Overview of Broad Institute Eric Lander
9:15 AM – 10:45 AM First Plenary Session Genome Biology | Chad Nusbaum 9:15 Eric Lander Overview of the Genome Biology Program 9:30 Sheila Fisher Next-Generation Process Development and Implementation in the Sequencing Platform 9:45 George Church Personal and Synthetic “-omes” 10:00 Matthew Henn Linking Viral Genomic Diversity with Disease 10:15 Dawn-Anne Thompson A Functional Genomics Analysis of Central Carbon Metabolism Evolution in Yeasts 10:30 John Rinn Large Intervening Non-Coding RNAs (lincRNA): The Missing ‘lincs’ of the Transcriptome
10:45 AM – 11:15 AM Break Metabolic Disease|Vamsi Mootha Educational Outreach|MeganRokop Session Plenary Third 1:40 Lunch 12:20 Psychiatric Disease|EdwardScolnick Session Plenary Second 11:15 Large-scale Chemical Biology of the the of Mitochondrion Biology Chemical Large-scale Kitami Toshimori 2:55 Mass Index New GeneticLociforHumanHeight andBody 2:40 ElizabethSpeliotes Epigenomic ApproachestoAdipogenesis 2:25 EvanRosen Metabolite Profiling atBroadInstitute 2:10 ClaryClish Overview oftheMetabolicDiseaseInitiative 1:55 JoelHirschhorn Next the Generation ofScientists to Broadies Connecting Outreach Program: Educational Institute Broad The 1:40 MeganRokop Pathway Signaling Wnt the with Interacts DISC-1 isanEssentialEmbryonicGenethat 11:50 YingweiMao&GianlucaDeRienzo for Schizophrenia The RoleofCommonGeneticVariation onRisk 11:35 ShaunPurcell Studies Association Genome-Wide by Identified Schizophrenia in Variation Number Copy Stone Jennifer 11:20 Program Disease Psychiatric the of Overview Scolnick Edward 11:15 PM PM AM –3:10 –1:40 – 12:20 PM PM PM
3 Broad Institute | Fourth Annual Scientific Retreat 3:10 PM – 3:40 PM Fourth Annual Scientific Break Retreat 3:40 PM – 5:10 PM November 3RD Fourth Plenary Session Chemical Biology | Michelle Palmer 2008 3:40 Stuart Schreiber HMS Overview of the Chemical Biology Program: New Research Building The Gap Between Scientists’ Aspirations and Society’s Expectations 3:55 Mike Foley Transforming Small-Molecule Screening Collection 4:10 Angela N. Koehler Targeting Transcription Factors with Small Molecules 4:25 Kimberly Hartwell Targeting Leukemic Stem Cells within their Stromal Niche 4:40 Anna Mandivona Targeting p53 in Cells and Mice 4:55 Monica Schenone Quantitating Small Molecule/Protein Interactions in Cells
5:10 PM – 7:10 PM Poster Session I and Reception Genome Biology, Psychiatric Disease, Metabolic Disease, Educational Outreach, and Chemical Biology TH Fourth Annual Agenda | November 4 2008 Scientific Retreat 8:15 AM – 9:00 AM Registration and Poster Session II Set-Up November 4TH Breakfast 2008
HMS 9:00 AM – 10:30 AM New Research Building First Plenary Session Cancer | Tyler Jacks 9:00 Todd Golub Overview of the Cancer Program 9:15 Matthew Meyerson Cancer Genome Characterization 9:30 Jesse Boehm Update on Project Achilles 9:45 Aravind Subramanian Connectivity Map 3.0 10:00 Yujin Hoshida Outcome Prediction in Hepatocellular Carcinoma 10:15 Margaret A. Shipp Molecular Signatures and Rational Treatment Targets in Lymphoma
10:30 AM – 11:00 AM Break
11:00 AM – 12:45 PM Second Plenary Session Medical and Population Genetics | David Altshuler 11:00 Mark Daly Overview of the Medical and Population Genetics Program 11:15 Ramnik Xavier Crohn’s Disease Pathogenesis Break 2:30 Cell CircuitsandRNAi|DavidRoot Third PlenarySession 1:30 Lunch 12:45 Discovery ofHumanTrait Genes Power ofDeepAll-ExonResequencingfor Sunyaev Shamil 12:30 1000 GenomesProject andMedicalSequencing Gabriel Stacey 12:15 Ancestry Genetic Trans and Cis Both Americans with Vary African in Levels Expression Gene Price L. Alkes 12:00 Schizophrenia Function AmongRareGeneDeletionsin Using aText-Based ApproachtoFindaShared 11:45 SoumyaRaychaudhuri Attack? Risk Heart Causal a for is Factor Cholesterol Lipoprotein Density Can HumanGeneticsHelpAnswerifHigh- Kathiresan Sekar 11:30 RNAi, Mass Spec, and Transcriptional Signature Signature Analysis Transcriptional of and Spec, Integration Mass RNAi, Network: Insulin the of Elucidation Kulkarni Meghana 2:15 How Receptor Tyrosine KinasesProcess Information Understanding to Approach Data-Driven A MacBeath Gavin 2:00 for ModifiersoftheDNADamageResponse Combined SmallMoleculeandRNAiScreening Floyd Scott 1:45 Overview oftheCellCircuitsProgram Yaffe Mike 1:30 PM PM PM –3:00 –2:30 –1:30 PM PM PM
7 Broad Institute | Fourth Annual Scientific Retreat 3:00 PM – 4:00 PM Fourth Annual Scientific Fourth Plenary Session Retreat Infectious Disease |Jon Clardy 3:00 Dyann Wirth Overview of the Infectious Disease Initiative November 4TH 2008 3:15 Pardis Sabeti Malaria Parasite Diversity HMS New Research 3:30 Branch Moody Building Mass Spectrometric Profiling of the Lipid Barrier Between M. tuberculosis and its Host 3:45 Michael Fischbach Genomics as a Tool for Natural Product Discovery
4:00 PM – 4:15 PM Closing Remarks Eric Lander
4:15 PM – 6:15 PM Formal Poster Session II and Reception Cancer, Medical and Population Genetics, Cell Circuits and RNAi, Infectious Disease Initiative, and Broad Scientific Medley