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Inside the Ebola Wars the New Yorker
4/13/2017 Inside the Ebola Wars The New Yorker A REPORTER AT LARGE OCTOBER 27, 2014 I﹙UE THE EBOLA WARS How genomics research can help contain the outbreak. By Richard Preston Pardis Sabeti and Stephen Gire in the Genomics Platform of the Broad Institute of M.I.T. and Harvard, in Cambridge, Massachusetts. They have been working to sequence Ebola’s genome and track its mutations. he most dangerous outbreak of an emerging infectious disease since the appearance of H.I.V., in the early nineteen-eighties, seems to have begun on DTecember 6, 2013, in the village of Meliandou, in Guinea, in West Africa, with the death of a two-year-old boy who was suffering from diarrhea and a fever. We now know that he was infected with Ebola virus. The virus is a parasite that lives, normally, in some as yet unidentified creature in the ecosystems of equatorial Africa. This creature is the natural host of Ebola; it could be a type of fruit bat, or some small animal that lives on the body of a bat—possibly a bloodsucking insect, a tick, or a mite. Before now, Ebola had caused a number of small, vicious outbreaks in central and eastern Africa. Doctors and other health workers were able to control the outbreaks quickly, and a belief developed in the medical and scientific communities that Ebola was not much of a threat. The virus is spread only through direct contact with blood and bodily fluids, and it didn’t seem to be mutating in any significant way. -
News Harvard University
THE CENTER FOR MIDDLE EASTERN STUDIES, NEWS HARVARD UNIVERSITY SPRING 2015 1 LETTER FROM THE DIRECTOR A message from William Granara 2 SHIFTING TOWARDS THE ARABIAN PENINSULA Announcing a new lecture series 3 NEWS AND NOTES Updates from faculty, students and visiting researchers 12 EVENT HIGHLIGHTS Spring lectures, workshops, and conferences LETTER FROM THE DIRECTOR SPRING 2015 HIGHLIGHTS I’M HAPPY TO REPORT THAT WE ARE DRAWING TO THE CLOSE OF AN ACADEMIC YEAR FULL OF ACTIVITY. CMES was honored to host a considerable number of outstanding lectures this year by eminent scholars from throughout the U.S. as well as from the Middle East and Europe. I mention only a few highlights below. Our new Middle Eastern Literatures initiative was advanced by several events: campus visits by Arab novelists Mai Nakib (Kuwait), Ahmed Khaled Towfik (Egypt), and Ali Bader (Iraq); academic lectures by a range of literary scholars including Hannan Hever (Yale) on Zionist literature and Sheida Dayani (NYU) on contemporary Persian theater; and a highly successful seminar on intersections between Arabic and Turkish literatures held at Bilgi University in Istanbul, which included our own Professor Cemal Kafadar, several of our graduate students, and myself. In early April, CMES along with two Harvard Iranian student groups hosted the first Harvard Iranian Gala, which featured a lecture by Professor Abbas Milani of Stanford University and was attended by over one hundred guests from the broader Boston Iranian community. Also in April, CMES co-sponsored an international multilingual conference on The Thousand and One Nights with INALCO, Paris. Our new Arabian Peninsula Studies Lecture Series was inaugurated with a lecture by Professor David Commins of Dickinson College, and we are happy to report that this series will continue in both the fall and spring semesters of next year thanks to the generous support of CMES alumni. -
Outbreak of SARS-Cov-2 Infections, Including COVID-19 Vaccine
Morbidity and Mortality Weekly Report Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021 Catherine M. Brown, DVM1; Johanna Vostok, MPH1; Hillary Johnson, MHS1; Meagan Burns, MPH1; Radhika Gharpure, DVM2; Samira Sami, DrPH2; Rebecca T. Sabo, MPH2; Noemi Hall, PhD2; Anne Foreman, PhD2; Petra L. Schubert, MPH1; Glen R. Gallagher PhD1; Timelia Fink1; Lawrence C. Madoff, MD1; Stacey B. Gabriel, PhD3; Bronwyn MacInnis, PhD3; Daniel J. Park, PhD3; Katherine J. Siddle, PhD3; Vaira Harik, MS4; Deirdre Arvidson, MSN4; Taylor Brock-Fisher, MSc5; Molly Dunn, DVM5; Amanda Kearns5; A. Scott Laney, PhD2 On July 30, 2021, this report was posted as an MMWR Early Massachusetts, that attracted thousands of tourists from across Release on the MMWR website (https://www.cdc.gov/mmwr). the United States. Beginning July 10, the Massachusetts During July 2021, 469 cases of COVID-19 associated Department of Public Health (MA DPH) received reports of with multiple summer events and large public gatherings in an increase in COVID-19 cases among persons who reside in a town in Barnstable County, Massachusetts, were identified or recently visited Barnstable County, including in fully vac- among Massachusetts residents; vaccination coverage among cinated persons. Persons with COVID-19 reported attending eligible Massachusetts residents was 69%. Approximately densely packed indoor and outdoor events at venues that three quarters (346; 74%) of cases occurred in fully vac- included bars, restaurants, guest houses, and rental homes. On cinated persons (those who had completed a 2-dose course July 3, MA DPH had reported a 14-day average COVID-19 of mRNA vaccine [Pfizer-BioNTech or Moderna] or had incidence of zero cases per 100,000 persons per day in residents received a single dose of Janssen [Johnson & Johnson] vac- of the town in Barnstable County; by July 17, the 14-day cine ≥14 days before exposure). -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
Arxiv:2003.13670V4 [Cs.CY] 3 Apr 2020 IV Program
Anonymous Collocation Discovery: Harnessing Privacy to Tame the Coronavirus∗ Ran Canetti† Ari Trachtenberg‡ Mayank Varia§ Boston University April 7, 2020 Abstract Successful containment of the Coronavirus pandemic rests on the ability to quickly and reliably identify those who have been in close proximity to a contagious individual. Existing tools for doing so rely on the collection of exact location information of individuals over lengthy time periods, and combining this information with other personal information. This unprecedented encroachment on individual privacy at national scales has created an outcry and risks rejection of these tools. We propose an alternative: an extremely simple scheme for providing fine-grained and timely alerts to users who have been in the close vicinity of an infected individual. Crucially, this is done while preserving the anonymity of all individuals, and without collecting or storing any personal information or location history. Our approach is based on using short-range communication mechanisms, like Bluetooth, that are available in all modern cell phones. It can be deployed with very little infrastructure, and incurs a relatively low false-positive rate compared to other collocation methods. We also describe a number of extensions and tradeoffs. We believe that the privacy guarantees provided by the scheme will encourage quick and broad voluntary adoption. When combined with sufficient testing capacity and existing best practices from healthcare professionals, we hope that this may significantly reduce the infection rate. To avoid confusion, we stress that this work does not propose any direct medical treatment. arXiv:2003.13670v4 [cs.CY] 3 Apr 2020 Rather, it proposes a way to pool together information from the community in order to help (a) direct medical personnel in how to best allocate and use testing resources, and (b) direct individuals as to when to get tested and self-quarantine. -
Anew Drug Design Strategy in the Liht of Molecular Hybridization Concept
www.ijcrt.org © 2020 IJCRT | Volume 8, Issue 12 December 2020 | ISSN: 2320-2882 “Drug Design strategy and chemical process maximization in the light of Molecular Hybridization Concept.” Subhasis Basu, Ph D Registration No: VB 1198 of 2018-2019. Department Of Chemistry, Visva-Bharati University A Draft Thesis is submitted for the partial fulfilment of PhD in Chemistry Thesis/Degree proceeding. DECLARATION I Certify that a. The Work contained in this thesis is original and has been done by me under the guidance of my supervisor. b. The work has not been submitted to any other Institute for any degree or diploma. c. I have followed the guidelines provided by the Institute in preparing the thesis. d. I have conformed to the norms and guidelines given in the Ethical Code of Conduct of the Institute. e. Whenever I have used materials (data, theoretical analysis, figures and text) from other sources, I have given due credit to them by citing them in the text of the thesis and giving their details in the references. Further, I have taken permission from the copyright owners of the sources, whenever necessary. IJCRT2012039 International Journal of Creative Research Thoughts (IJCRT) www.ijcrt.org 284 www.ijcrt.org © 2020 IJCRT | Volume 8, Issue 12 December 2020 | ISSN: 2320-2882 f. Whenever I have quoted written materials from other sources I have put them under quotation marks and given due credit to the sources by citing them and giving required details in the references. (Subhasis Basu) ACKNOWLEDGEMENT This preface is to extend an appreciation to all those individuals who with their generous co- operation guided us in every aspect to make this design and drawing successful. -
Issue 253 ▸ 1 November 2012 Reportersharing Stories of Imperial’S Community
Issue 253 ▸ 1 November 2012 reporterSharing stories of Imperial’s community fringe benefits Visitors to the first Imperial Fringe take things to heart as they get to grips with our research → centre pages £35 MILLION FORWARD LONDON AWARD FOR THINKING BIKEATHON IMPERIAL Dr Simon Professor Dazzi HEFCE support Schultz on the on cycling 95 for Imperial value of looking miles with his West to the future patient PAGE 3 PAGE 7 PAGE 12 2 >> newsupdate www.imperial.ac.uk/reporter | reporter | 1 November 2012 • issue 253 Researchers unite to open up about animal research EDITOR’S CORNER Imperial has joined medical charities, remain high overall, with 66 per cent research funders, the pharmaceuti- of people supporting animal experi- cal industry and other universities mentation for medical research, Pregnant in signing a declaration for greater 40 per cent want to know more openness on animal research fol- before they form a firm opinion. pause lowing signs of a decrease in public Professor Maggie Dallman, “I hope this declaration will give s upport for animal research. Principal of the Faculty of Natural organisations and scientists the con- The results of a recent Ipsos Sciences, said: “Animal research fidence to speak out with the support As a number of you might Mori poll commissioned by the is a small but vital part of scientific of the wider research community.” know this is my final government reveal a 10 percentage and medical research in the UK. Ter- The declaration was signed by issue of Reporter before point decrease in public support for rorist activity by animal extremists in more than 40 research organisations, I go on maternity leave. -
Qnas with Pardis Sabeti QNAS
QNAS QnAs with Pardis Sabeti QNAS Sandeep Ravindran, Science Writer Pardis Sabeti received the 2017 National Academy of and really understand how the Sciences Richard Lounsbery Award in biology for her malaria parasites are changing groundbreaking work in computational genetics and to survive against our immune global health. A professor at Harvard University, the system and the drug pressures Broad Institute, and the Howard Hughes Medical we put on them. Institute, Sabeti has developed computational meth- ods to detect genetic variants under natural selection, PNAS: In 2014 you published and has applied these methods to both humans and alandmarkScience article on pathogens. She has conducted pioneering genomic the human-to-human transmis- analyses of Ebola and Lassa viruses, and her work sion of the Ebola virus (4). How played an important role in tracking Ebola transmis- did that article come about, sion during the 2014 outbreak in West Africa. Sabeti and what was its significance? recently spoke with PNAS about her efforts to combat emerging diseases. Sabeti: In 2014 our group was working with our collaborators PNAS: How did you first get interested in computational in Sierra Leone and in Nigeria genetics? on a disease called Lassa fe- ver, which is a hemorrhagic ’ Sabeti: I ve always really liked math and solving puz- fever virus much like Ebola. Pardis Sabeti. Photograph by Morgan Miller zles with math. I really enjoyed my math courses in We had gotten a grant to set and courtesy of Pardis Sabeti. college at MIT [Massachusetts Institute of Technol- up surveillance in West Africa ogy], but I also wanted to impact human health. -
Science News
COVID-19 Lessons From Colleges | Impostor Fossils MAGAZINE OF THE SOCIETY FOR SCIENCE s FEBRUARY 27, 2021 Solar Storms Scientists amp up efforts to protect Earth from what the sun throws at us cover.indd 1 2/10/21 1:52 PM Cognitive Behavioral Therapy for Daily Life Taught by Professor Jason M. Satterfi eld TIME ED O , T FF I E IM R L 1. A CBT Toolbox: Toward Wise Living 70% 2. Laying a Foundation: Assessments and Goals 1 O off 3. Behavioral Activation: Potent Mood Boosters R H C DE R 4. Advanced Behavioral Techniques R B MA Y 5. Capturing Thoughts and Making Connections 6. Cognitive Restructuring and Thought Records 7. Worry, Rumination, and Sticky Thoughts 8. Digging Deeper: Rules and Core Beliefs 9. Toolbox in Action: Stress and Assertiveness 10. Understanding and Managing Emotions 11. Key Steps to Solving Problems 12. Grief, Sadness, and Depression 13. Panic Attacks and Anxiety 14. Addiction and Pain Medications 15. Embracing Imperfection 16. Beating Procrastination 17. Soothing Rejection, Promoting Connection 18. Early Childhood Trauma and Neglect 19. Managing Chronic Disease 20. Coping with Chronic Pain 21. How to End Insomnia and Finally Sleep A Powerful Way to Take 22. CBT for the Beginning of the End of Life 23. Expanding CBT with Technology Control of Your Life 24. Reclaiming and Rewriting Our Stories Why is life so challenging? Life presents daily challenges such as difficult coworkers, chronic pain, marital conflicts, grief, parenting issues, and Cognitive Behavioral Therapy for Daily Life Course no. 9661 | 24 lectures (30 minutes/lecture) more. -
Picking up Evolution's Beat
NEWSFOCUS PROFILE: PARDIS SABETI Florida, with a large extended family. She traces her academic success to her Picking Up Evolution’s Beat on April 24, 2008 early life in this close-knit clan. “My mother Pardis Sabeti mixes geek cool with hot science as she studies how human created a summer camp in our house, where populations have evolved to resist malaria and Lassa fever she would teach the children and make us do book reports. And my sister, who is 2 years CAMBRIDGE, MASSACHUSETTS—Over the Stevie Wonder, and Meryl Streep), and CNN older than me, would teach me and my past 72 hours, Pardis Sabeti has managed named her one of eight “geniuses who will cousin what she had learned in school.” only 2 hours of sleep each night, most of change your life.” Sabeti says mathematics was her first love. them inside a crumpled blue sleeping bag Sabeti also seems to have a genius for Her high-energy personality, she adds, she keeps under a desk at the Broad Institute raising money. While still a postdoc, her appeared in those early years. “I’m a hyper www.sciencemag.org Center for Genome Research in Cambridge, own grants totaled more than $600,000, and person,” she says. “My parents always told Massachusetts. Sabeti, who burst on the sci- she is currently a co-investigator on a me to relax.” entific scene in 2002 with a novel test for $2 million Bill and Melinda Gates Founda- Reich, who met Sabeti when they were natural selection in the human genome, has tion grant. -
2018 Annual Review 2018 Annual Review
2018 Annual Review 2018 Annual Review LT AR.indd 1 29/04/2019 08:48 LT AR.indd 2 29/04/2019 08:48 Contents 5 Introduction 46 Astate of theart conservatoire 7Chairman’sForeword 48 Transnationalpractices:film cultureand politics in China, 1949–1989 8History of theLeverhulmeTrust 50 Rhetorical structures:architecturalsettingsin 10 Grants theTrust Offers EarlyRenaissance Italianpainting 12 Director’s Report 52 Promotingpathwaysfor learningdisabled 13 Summarised FinancialInformation dancers 14 2018 in Numbers 54 The penand theplough:modernBritish nature writingand thefarm 56 BrianAttebery, LeverhulmeVisitingProfessor 17 Grants in Focus of Fantasy 18 Learning aboutageingfromashort-lived fish 58 WartimeShakespeare:the fashioning of public opinion throughperformance 20 ‘The aristocratic traditionatits best’? Shaftesbury, philanthropy and reform 60 Rethinking complexity in facial communication systems 22 Visualisingpower and justice in late medieval romancemanuscripts 62 Double agent: HeinrichSimon’s constitutional missioninneo-absolutistPrussia 24 On thetrail of dinosaursand themammals that replaced them 64 Dynamics of theinner MilkyWay with Gaia 26 Ourfutureheritage: conservation issues of 66 Space–timeand themanuscript: 4D modelling contemporary architecture in medieval book design 28 Uncovering themechanismsofmigratory bird 68 Leverhulme Centre forWildfires, Environment navigation with bigdataanalytics and Society 30 Experimental gravitational-wave physics, designingand buildingthe world’smost preciserulers 71 What Happened Next: 32 Looseends: -
Epigenetic Therapeutics in Malaria
Epigenetic therapeutics in malaria: A chemical biological approach towards the validation of histone lysine methyltransferase inhibition in Plasmodium falciparum Alexandra Lubin PhD Thesis Supervisor: Dr Matthew Fuchter Department of Chemistry, Imperial College London March 2018 Declaration of Originality I confirm that the work presented within this thesis is entirely my own, conducted under the supervision of Dr Matthew J. Fuchter, at the Department of Chemistry, Imperial College London, unless otherwise stated. All work performed by others has been acknowledged within the text and referenced where appropriate. Copyright Declaration The copyright of this thesis rests with the author and is made available under a Creative Commons Attribution Non-Commercial No Derivatives licence. Researchers are free to copy, distribute or transmit the thesis on the condition that they attribute it, that they do not use it for commercial purposes and that they do not alter, transform or build upon it. For any reuse or redistribution, researchers must make clear to others the licence terms of this work. 2 Abstract A growing threat from drug resistance means there is an urgent need for new therapeutics and novel mechanisms of action for antimalarial drug discovery. Epigenetic mechanisms, including histone methylation, are vital throughout the Plasmodium lifecycle, and could provide exciting new targets. BIX-01294 and a series of diaminoquinazolines are putative Plasmodium histone lysine methyltransferase inhibitors, with exciting antimalarial properties, although robust evidence for their molecular targets is lacking. To this end, a well-developed SAR for this series allowed for the development of small-molecule photo-crosslinkable probes to investigate the targets. These probes effectively label Plasmodium falciparum lysates and show similarities with the target profiles of BIX-01294 and the diaminoquinazoline series.