Broad Institute Fourth Annual Scientific Retreat November 3RD – 4TH | 2008 New Research Building at Harvard Medical School RD Fourth Annual Agenda | November 3 2008 Scientific Retreat 8:15 AM – 9:00 AM Registration and Poster Session I Set-Up November 3RD Breakfast 2008 HMS 9:00 AM – 9:15 AM New Research Building Welcome and Overview of Broad Institute Eric Lander 9:15 AM – 10:45 AM First Plenary Session Genome Biology | Chad Nusbaum 9:15 Eric Lander Overview of the Genome Biology Program 9:30 Sheila Fisher Next-Generation Process Development and Implementation in the Sequencing Platform 9:45 George Church Personal and Synthetic “-omes” 10:00 Matthew Henn Linking Viral Genomic Diversity with Disease 10:15 Dawn-Anne Thompson A Functional Genomics Analysis of Central Carbon Metabolism Evolution in Yeasts 10:30 John Rinn Large Intervening Non-Coding RNAs (lincRNA): The Missing ‘lincs’ of the Transcriptome 10:45 AM – 11:15 AM Break 11:15 AM – 12:20 PM Second Plenary Session Psychiatric Disease | Edward Scolnick 11:15 Edward Scolnick Overview of the Psychiatric Disease Program 11:20 Jennifer Stone Copy Number Variation in Schizophrenia Identified by Genome-Wide Association Studies 11:35 Shaun Purcell The Role of Common Genetic Variation on Risk for Schizophrenia 11:50 Yingwei Mao & Gianluca De Rienzo DISC-1 is an Essential Embryonic Gene that Interacts with the Wnt Signaling Pathway 12:20 PM – 1:40 PM Lunch 1:40 PM – 3:10 PM Third Plenary Session Educational Outreach | Megan Rokop Metabolic Disease | Vamsi Mootha 1:40 Megan Rokop The Broad Institute Educational Outreach Program: Connecting Broadies to the Next Generation of Scientists 1:55 Joel Hirschhorn Overview of the Metabolic Disease Initiative 2:10 Clary Clish Metabolite Profiling at Broad Institute 2:25 Evan Rosen Epigenomic Approaches to Adipogenesis 2:40 Elizabeth Speliotes New Genetic Loci for Human Height and Body Mass Index 2:55 Toshimori Kitami Broad Institute | Fourth Annual Scientific Retreat Large-scale Chemical Biology of the 3 Mitochondrion 3:10 PM – 3:40 PM Fourth Annual Scientific Break Retreat 3:40 PM – 5:10 PM November 3RD Fourth Plenary Session Chemical Biology | Michelle Palmer 2008 3:40 Stuart Schreiber HMS Overview of the Chemical Biology Program: New Research Building The Gap Between Scientists’ Aspirations and Society’s Expectations 3:55 Mike Foley Transforming Small-Molecule Screening Collection 4:10 Angela N. Koehler Targeting Transcription Factors with Small Molecules 4:25 Kimberly Hartwell Targeting Leukemic Stem Cells within their Stromal Niche 4:40 Anna Mandivona Targeting p53 in Cells and Mice 4:55 Monica Schenone Quantitating Small Molecule/Protein Interactions in Cells 5:10 PM – 7:10 PM Poster Session I and Reception Genome Biology, Psychiatric Disease, Metabolic Disease, Educational Outreach, and Chemical Biology TH Fourth Annual Agenda | November 4 2008 Scientific Retreat 8:15 AM – 9:00 AM Registration and Poster Session II Set-Up November 4TH Breakfast 2008 HMS 9:00 AM – 10:30 AM New Research Building First Plenary Session Cancer | Tyler Jacks 9:00 Todd Golub Overview of the Cancer Program 9:15 Matthew Meyerson Cancer Genome Characterization 9:30 Jesse Boehm Update on Project Achilles 9:45 Aravind Subramanian Connectivity Map 3.0 10:00 Yujin Hoshida Outcome Prediction in Hepatocellular Carcinoma 10:15 Margaret A. Shipp Molecular Signatures and Rational Treatment Targets in Lymphoma 10:30 AM – 11:00 AM Break 11:00 AM – 12:45 PM Second Plenary Session Medical and Population Genetics | David Altshuler 11:00 Mark Daly Overview of the Medical and Population Genetics Program 11:15 Ramnik Xavier Crohn’s Disease Pathogenesis 11:30 Sekar Kathiresan Can Human Genetics Help Answer if High- Density Lipoprotein Cholesterol is a Causal Risk Factor for Heart Attack? 11:45 Soumya Raychaudhuri Using a Text-Based Approach to Find a Shared Function Among Rare Gene Deletions in Schizophrenia 12:00 Alkes L. Price Gene Expression Levels in African Americans Vary with Both Cis and Trans Genetic Ancestry 12:15 Stacey Gabriel 1000 Genomes Project and Medical Sequencing 12:30 Shamil Sunyaev Power of Deep All-Exon Resequencing for Discovery of Human Trait Genes 12:45 PM – 1:30 PM Lunch 1:30 PM – 2:30 PM Third Plenary Session Cell Circuits and RNAi | David Root 1:30 Mike Yaffe Overview of the Cell Circuits Program 1:45 Scott Floyd Combined Small Molecule and RNAi Screening for Modifiers of the DNA Damage Response 2:00 Gavin MacBeath A Data-Driven Approach to Understanding How Receptor Tyrosine Kinases Process Information 2:15 Meghana Kulkarni Elucidation of the Insulin Network: Integration of RNAi, Mass Spec, and Transcriptional Signature Analysis Broad Institute | Fourth Annual Scientific Retreat 2:30 PM – 3:00 PM 7 Break 3:00 PM – 4:00 PM Fourth Annual Scientific Fourth Plenary Session Retreat Infectious Disease |Jon Clardy 3:00 Dyann Wirth Overview of the Infectious Disease Initiative November 4TH 2008 3:15 Pardis Sabeti Malaria Parasite Diversity HMS New Research 3:30 Branch Moody Building Mass Spectrometric Profiling of the Lipid Barrier Between M. tuberculosis and its Host 3:45 Michael Fischbach Genomics as a Tool for Natural Product Discovery 4:00 PM – 4:15 PM Closing Remarks Eric Lander 4:15 PM – 6:15 PM Formal Poster Session II and Reception Cancer, Medical and Population Genetics, Cell Circuits and RNAi, Infectious Disease Initiative, and Broad Scientific Medley.