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Home , Cell (biology), Cell biology

BIOL 288 Winter 2021

COURSE OVERVIEW: This course will provide you with a basic and comprehensive understanding of cell and . I will try to balance the breadth of topics with their depth to help you gain an appreciation of the diversity and complexity of cellular functions. We will discuss the molecular composition of cellular components and , and how these and their interactions ultimately dictate cell structure and function. I expect that you will leave this course with an appreciation for the importance of understanding cellular and molecular processes in order to comprehend larger scale physiological, organismal and ecological processes.

INSTRUCTORS: Please contact us using the emails below. We do not use UR Courses for email.

Lecture: Dr. Lori Manzon Lab: Dr. Nola Erhardt Email: [email protected] Email: [email protected] Lectures: Synchronous via Zoom on MWF Labs: Synchronous via Zoom on from 11:30 am-12:20 pm MTWR from 2:30-5:15 pm Office Hours: Zoom room by appointment.

PREREQUISITES: Introductory Biology (BIOL 100 & 101), General (CHEM 104)

COURSE WEBSITE: https://urcourses.uregina.ca/course/view.php?id=2278

TEXTBOOK (OPTIONAL): Karp, G., Iwasa, J., Marshall, W. 2019. Karp's Cell and , 9th Edition. Wiley. Older copies are acceptable.

OTHER VALUABLE TEXT RESOURCES: Introductory texts (several are on reserve in the library) Introductory texts Cells: Molecules & Mechanisms (Wong), BioLibre. https://bio.libretexts.org/Bookshelves/Cell_and_Molecular_Biology/Book%3A_Cells_- _Molecules_and_Mechanisms_(Wong)

1 GRADING SCHEME AND IMPORTANT DATES Date Value Lecture – Midterm 1 (Units 1-4) Friday, February 12, 2021 12% Lecture – Midterm 2 (Units 5 & 6) Friday, March 19, 2021 18% Lecture – Final Exam (Cumulative) Monday, April 26, 2021 from 9 am-12 pm 40% Lab – Reports and assignments See lab syllabus for details 30% TOTAL 100%

POLICY ON LATE LAB ASSIGNMENTS: See lab manual

POLICY ON MISSED EXAMS: “Deferred” final exams are granted only by the Associate Dean, Undergraduate (for Faculty of Science students), or by the Deans and/or Associate Deans of other Faculties or Federated Colleges of the University Regina. There are no exceptions.

STUDENT CONDUCT Students of the University of Regina are expected to conduct themselves responsibly and with propriety both in their studies and in their general behaviour, and are expected to abide by all policies and regulations of the University of Regina. Misconduct, which may be academic (that is, in academic studies) or non-academic (in general behaviour), is subject to disciplinary action. Students are reminded that this course falls under the ACADEMIC REGULATIONS OF THE UNIVERSITY OF REGINA. See pages 42-49 in the Undergraduate Calendar. https://www.uregina.ca/student/registrar/resources-for-students/academic- calendars-and-schedule/undergraduate-calendar/index.html

STUDENT ACCOMMODATIONS Any student who may need accommodations should discuss these with the course instructor AFTER meeting with an Accessibility Advisor through the Centre for Student Accessibility (306-585-4631).

RECORDINGS AND STUDENT PRIVACY Our Zoom class sessions WILL BE RECORDED and posted to UR Courses to better support the needs of all students. As a result, the University of Regina may collect your image, voice, name, personal views and opinions, and course work under the legal authority of The Local Authority Freedom of Information and Protection of Privacy Act.

Students who participate in a Zoom session with their video on or use a profile image are consenting to have their video or image recorded (including anything visible in the background). If you have concerns with such recording, be sure to keep your video off and do not use a profile image. In addition, students who un-mute their microphone during class and participate orally are consenting to have their voices, and personal views and opinions recorded. If you are unwilling to consent to this recording, please do not un- mute your microphone during class. If you have any questions about the collection or use of your personal information, please contact your instructor.

Any time that a student would like to ask a question during the lecture, the recording will be paused and then resumed afterward. Longer questions can be posed to the instructors directly, or via URCourses.

2 OTHER IMPORTANT INFORMATION: 1. I will review the following material, BUT I expect/assume that all students in the class have basic knowledge and understanding of: • Chemical bonds, interactions and forces that hold molecules together • Molecules of : water, , , amino acids and nucleotides • The 4 main larger molecules in the cell: lipids, carbohydrates, and nucleic acids • Basic knowledge of the different eukaryotic cellular organelles

2. Lecture notes and slides will be posted to UR Courses prior to each lecture.

3. Lecture exams will be based on material presented in class. The order of topics and the depth at which they are discussed in lecture may differ significantly from the textbook(s). However, the optional and recommended textbooks are invaluable references to supplement lecture material and ensure that you are gaining a complete and in-depth understanding of the lecture material.

4. I will review sessions prior to each exam. These will be held outside of our regular lecture time.

5. I will not be using Proctortrack.

6. Images in lecture are COPYRIGHT PROTECTED and reprinted with permission for the purpose of this course. YOU ARE NOT PERMITTED TO MODIFY OR DISTRIBUTE SLIDES OR IMAGES.

LAB SYLLABUS – Date refers to your particular lab day during that week.

Date and Time Activity Value Read material posted on UR Courses. You will need to have this Jan. 18-21 at any time completed prior to the first Zoom meeting the week of Jan. 25-28. Jan. 25-28 at 2:30 pm Zoom meeting to discuss Assignment #1: Research Proposal

Feb. 1-4 by 11:00 pm Assignment #1 due 7% Zoom meeting to discuss Assignment #2: Figures and Tables for Feb. 8-11 at 2:30 pm Scientific Paper Feb. 15-18 by 11:00 pm Assignment #2 due 5%

Feb. 22-26 at 2:30 pm Zoom meeting to discuss Assignment #3: Scientific Paper

Mar. 1-4 at 2:30 pm Zoom meeting to discuss Assignment #3: Scientific Paper

Mar. 8-11 by 11:00 pm Assignment #3 due 15%

At end of term Participation mark 3%

3 CELL BIOLOGY – BIOL 288 – WINTER 2021 – TENTATIVE LECTURE OUTLINE Date Topic Chapter Unit 1: Introduction to Cell Biology 1 11-Jan Unit 2: Chemistry of the Cell - Bonds & Interactions 2.1; 2.3 13-Jan Unit 2: Chemistry of the Cell - Water; Acids, Bases & Buffers 2.3-2.4 15-Jan Unit 3: Biological Molecules - Lipids, Carbohydrates & Nucleic Acids 18-Jan 2.7 Unit 3: Biological Molecules - Proteins 20-Jan 22-Jan Unit 4: - Functions & Models 4.1 25-Jan Unit 4: Membranes - Lipids & Proteins 4.2-4.4 27-Jan Unit 4: Membranes – Asymmetrical, Dynamic & Fluid 4.4-4.5 29-Jan Unit 4: Membranes - Simple 01-Feb Unit 4: Membranes - 4.6 03-Feb 05-Feb Unit 4: Membranes - 08-Feb Unit 5: - Metabolic Pathways & ATP 3.1, 3.3 10-Feb Unit 5: Metabolism - Glycolysis 3.3 12-Feb Midterm #1 (12%; Units 1-4) 15-Feb Winter break 22-Feb Unit 5: Metabolism – Mitochondria & the TCA Cycle 5.1-5.2 24-Feb Unit 5: Metabolism - 5.2-5.3 26-Feb Unit 5: Metabolism - Proton Motive Force & ATP Synthesis 5.5-5.6 01-Mar Unit 6: Endomembranes - Components of the 8.1-8.2 03-Mar Unit 6: Endomembranes - RER - Synthesis & Targeting 05-Mar 8.3 08-Mar Unit 6: Endomembranes – RER - Glycosylation & Quality Control 10-Mar Unit 6: Endomembranes – Golgi - Glycosylation & COP-Mediated Vesicular Transport 8.4-8.5 Unit 6: Endomembranes – Golgi – TGN Sorting, & -Mediated 12-Mar 8.5; 8.7; 8.9 15-Mar Unit 7: Communication – The Extracellular (ECM) 7.1 17-Mar Unit 7: Communication - Cell-ECM Interactions 7.3 19-Mar Midterm #2 (18%; Units 5 & 6) 22-Mar Unit 7: Communication - Cell-Cell Interactions 7.4-7.6 24-Mar 26-Mar Unit 7: Communication - Modes, Molecules & Receptors 15.1-15.3; 29-Mar Unit 7: Communication - & 15.7-15.10 31-Mar 9.1-9.2; 9.5; 05-Apr Unit 8: - Function & Components 9.7-9.8; 9.11 07-Apr Unit 8: Motility - -Based Movement - 9.4 09-Apr 12-Apr Unit 8: Motility - Microtubule-Based Movement - Motile Appendages 9.6 14-Apr Unit 8: Motility - -Based Movement 9.8; 9.12 26-Apr Final Exam (40%; Cumulative)

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