BALKAN MEDICAL UNION Founded in 1932 as „L’Union Médicale Balkanique“

Officers of the Balkan Medical Union

International Secretary General Camelia DIACONU, Romania

Presidents of national sections

Albania: Ylli POPA Bulgaria: Latchezar TRAYKOV Northern Cyprus: Hasan BESIM Greece: Marianna KARAMANOU North Macedonia: Ninoslav IVANOVSKI Republic of Moldova: Gheorghe CIOBANU Romania: Camelia DIACONU Turkey: Sabri ERGÜNEY Serbia: Vladmila BOJANIC´ Archives of the BALKAN MEDICAL UNION

Founding Editor M. POPESCU BUZEU , Romania

Editor-in-Chief Co-Editor-in-Chief Camelia DIACONU, Romania Irinel POPESCU, Romania

Honorary Editors Niki AGNANTIS, Greece Kaya BEKIROGˇLU , Northern Cyprus Ion ABABII, Republic of Moldova George ANDROUTSOS, Greece Somer ONES, Turkey

Editors Vladmila BOJANIC, Serbia Sabri ERGUNEY, Turkey Marianna KARAMANOU, Greece Hasan BESIM, Northern Cyprus Ninoslav IVANOVSKI, Fanny RIBAROVA, Bulgaria Gheorghe CIOBANU, North Macedonia Republic of Moldova

Assistant Editor Adriana MILEA, Romania

Editorial Board Süha AKPINAR, Northern Cyprus Gerald MAURER, Austria Raymond ARDAILLOU, France Minodora MAZUR, Republic of Moldova Daniela BARTOS, Romania Maja MILOJKOVIC´, Serbia Kandemir BEROVA, Northern Cyprus Igor NIKOLOV, North Macedonia Jean Louis BINET, France Theodore PAPAIOANNOU, Greece Zoran BOJANIC, Serbia Valentina PETKOVA, Bulgaria Andre BOURGEON, France Mentor PETRELA, Albania Giancarlo BRACALE, Italy Pierre Francois PLOUIN, France Koco CAKALAROSKI, North Macedonia Zivko POPOV, North Macedonia Olga CERNETCHI, Republic of Moldova Theodora PSALTOPOULOU, Greece Jean-Michel CORMIER, France Ninel REVENCO, Republic of Moldova Adrian-Valentin COTIRLET, Romania Gheorghe ROJNOVEANU, Republic of Moldova Daniel COUTURIER, France David L. ROWLAND, USA Stella DASKALOPOULOU, Canada Boryana RUSEVA, Bulgaria Sergulen DERVISOGLU, Turkey Zoubeir Ben SAFTA, Tunisie Roberto di DONATO, Italy Adrian SAFTOIU, Denmark, Romania Ionel DROC, Romania Vasile SARBU, Romania Ertugrul GAZIOGLU, Turkey Theodoros N. SERGENTANIS, Greece Gheorghe GHIDIRIM, Republic of Moldova Galina SEVEROVA, North Macedonia Fernando GOMEZ-FERRER BAYO, Spain Andrija ŠMELCEROVIC´, Serbia Veselina GORANOVA-MARINOVA, Bulgaria Nikolaos STERGIOPULOS, Switzerland Ioannis GRAMMATIKAKIS, Greece Grigore TINICA, Romania Michel HUGUIER, France Latchezar TRAYKOV, Bulgaria Mehmet INAN, Northern Cyprus Gregory TSOUCALAS, Greece Ognen IVANOVSKI, North Macedonia Ion TINTOIU, Romania Ioannis KAKADIARIS, USA Jovan VASILIEVIC, Serbia Ioannis KARAITIANOS, Greece Calin VICOL, Germany Afroditi KARAITIANOU-VELONAKI, Greece Tsekomir VODENITCHAROV, Bulgaria Ashraf W. KHIR, UK Junjie XIAO, China Ioan LASCAR, Romania

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Print: ISSN 1584-9244 ISSN-L 1584-9244 Online: ISSN 2558-815X CONTENTS

EDITORIAL

STATINS AND HEART FAILURE Camelia DIACONU ...... 401

ORIGINAL PAPER

EFFECTS OF 21-AMINOSTEROID U-74389G ON AMIODARONE-INDUCED PULMONARY TOXICITY IN RATS Galya Ts. STAVREVA, Violeta Y. DANCHEVA, Lyudmil G. TERZIEV, Plamen K. KRASTEV ...... 404 THE INTRACELLULAR MEDIATION DURING CHRONIC FLUORIDE INTOXICATION IN RATS Irina BAGMUT, Igor KOLISNYK, Anna TITKOVA, Svetlana GRAMATIUK, Liudmyla SVYRYDENKO ...... 411 INFLUENCE OF COMBINED NITRATE AND FLUORIDE INTOXICATION ON CONNECTIVE TISSUE DISORDERS IN RATS GASTRIC MUCOSA Oleh Y. AKIMOV, Arthur V. MISCHENKO, Vitalii O. KOSTENKO ...... 417 ORGANOMETRIC CHANGES OF RATS THYMUS AFTER XENOBIOTICS EXPOSURE Denys SHYIAN, Olga AVILOVA, Irina LADNAYA ...... 422 PROTEIN PEROXIDE OXIDATION IN THE CEREBRAL CORTEX AND HIPPOCAMPUS OF RATS WITH TYPE 2 DIABETES MELLITUS, UNDER CARBACETAM EFFECT Olga G. KMET, Nataliia D. FILIPETS, Tamara I. HRACHOVA, Yurii M. VEPRIUK, Kateryna V. VLASOVA ...... 431 THE ASSOCIATION OF KIDNEY STRESS TEST WITH WATER SALT LOADING WITH ESTIMATED GLOMERULAR FILTRATION RATE DECLINE IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 1-3 Dmytro IVANOV, Liybov SAVYTSKA, Veronika KULACHEK ...... 438 8-HYDROXY-DEOXYGUANOSINE AS AN INDEPENDENT PROGNOSTIC FACTOR IN PATIENTS WITH METASTATIC COLORECTAL CANCER Anton BURLAKA, Tymur RUDIUK, Anatoly BURLAKA, Olena KOLESNIK ...... 445 GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE M1 (GSTM1) IN PATIENTS WITH SUSCEPTIBLE AND RESISTANT TUBERCULOSIS Lilia D. TODORIKO, Igor O. SEMIANIV, Olga S. SHEVCHENKO, Tetiana M. BILOUS, Marianne M. SEMIANIV, Rostislav S. SHEVCHENKO, Volodymyr V. YAKYMETS ...... 455 THE CYTOKERATIN 18, ADIPONECTIN AND LEPTIN LEVELS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS AND CORONARY HEART DISEASE Oksana S. KHUKHLINA, Olha B. KUZMINSKA, Alona A. ANTONIV, Tamara H. KOPCHUK, Svitlana P. MELNYCHUK ...... 461 CHARACTERISTICS OF BONE MINERAL DENSITY AND DENSITOMETRY DATA IN PATIENTS WITH OSTEOARTHRITIS, NON-ALCOHOLIC STEATOHEPATITIS AND OBESITY Oksana S. KHUKHLINA, Oksana D. LIAKHOVYCH, Ludmila V. KANIOVSKA, Vera O. SHUPER, Iryna B. HORBATIUK, Olha Ye. HRYNIUK ...... 467 MICROCIRCULATION CHANGES IN THE AREA OF RESTORATION OF OSSEOUS DEFECTS OF JAWS USING POLYMERIC FIBROUS MATRIX Andrii V. PANTUS, Nazar Ya. SLYUSARENKO, Nataliia E. KOVALCHUK, Iryna R. YARMOSHUK, Volodymyr L. KOGUT ...... 473 ALTERED MANDIBULAR DYNAMICS BETWEEN BRUXISM AND TEMPOROMANDIBULAR JOINT DYSFUNCTION Daiana DEBUCEAN, Petru MIHANCEA, Marius S. POP ...... 480 BIOCOMPATIBILITY OF MESENCHYMAL STROMAL CELLS OF ADIPOSE TISSUE WITH OSTEOPLASTIC MATERIALS (IN VITRO) Andrii BAMBULIAK ...... 486 IMPACT OF VASCULAR RISK FACTORS ON COGNITIVE DECLINE ASSOCIATED WITH DIABETES MELLITUS Mirena P. VALKOVA, Ivanka I. VELEVA, Velina N. GUERGUELTCHEVA, Presian S. BURGOV ...... 492 IMPROVING THE DRUG COMPLIANCE OF HYPERTENSIVE PATIENTS IN PRIMARY CARE: IMPORTANCE OF HEALTH EDUCATION AND SELF-MANAGEMENT Oleksii KORZH, Sergiy KRASNOKUTSKIY, Olena PANKOVA ...... 497 THE ROLE OF HOMOCYSTEINE AND OTHER ENDOGENOUS INTOXICATION MARKERS IN THE PATHOGENESIS OF LICHEN PLANUS Tetiana V. MELNYK, Sergiy A. BONDAR ...... 503 IMMUNOHISTOCHEMICAL STUDY OF VON WILLEBRAND’S FACTOR AS A MARKER OF ENDOTHELIAL DYSFUNCTION OF UTERO-PLACENTAL AREA AND MYOMETRIUM IN PREGNANCY Olena A. TIULIENIEVA, Igor S. DAVYDENKO, Oleksandra V. GARVASIUK, Anastasiia V. HOIAN ...... 508 THE ROLE OF MULTIPLE REGRESSION ANALYSIS IN PREDICTION OF INSULIN RESISTANCE IN OVERWEIGHT AND OBESE CHILDREN Halyna PAVLYSHYN, Kateryna KOZAK ...... 514 GIARDIASIS IN CHILDREN: MOLECULAR GENOTYPING, GROWTH AND CALPROTECTIN LEVELS Tamila V. SOROKMAN, Snizhana V. SOKOLNYK, Alexandra-Maria V. POPELYUK, Tetyana O. BEZRUK, Volodymyr V. BEZRUK, Natalia O. POPELYUK ...... 522 MORPHOMETRY OF PODOCYTES – A SINGLE CENTER STUDY OF PEDIATRIC PATIENTS: IS THERE ANY CORRELATION WITH PROTEINURIA LEVEL? Diana DEREWICZ, Roxana TARAS, Cosmin FLORESCU, Mihaela BALGRADEAN, Maria SAJIN ...... 532 STUDY OF THE DIETARY MINERALS INTAKE OF CHILDREN WITH EARLY CHILDHOOD CARIES Mariana I. DIMOVA-GABROVSKA, Desislava G. DIMITROVA ...... 540 NEW SYSTEM OF MESH FIXATION FOR „ONLAY HERNIA REPAIR“, BASED ON A NEW PRINCIPLE – „THE EQUALLY-DISTRIBUTED-TENSION PRINCIPLE“ – INNOVATIVE SURGICAL TECHNIQUE Radu V. COSTIN ...... 549 REVIEW

GASTROINTESTINAL AND NEUROLOGICAL MANIFESTATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS Gina GHEORGHE, Gabriela CEOBANU, Madalina ILIE, Ana Maria A. STANESCU, Ovidiu G. BRATU, Camelia C. DIACONU ...... 555 WHAT WE SHOULD KNOW ABOUT CEREBELLOPONTINE ANGLE NON-VESTIBULAR SCHWANNOMA? Mihaela HOROI, Serban V. BERTESTEANU, Bogdan POPESCU, Raluca GRIGORE, Marie-Paule THILL ...... 561 STATE OF THE ART ANATOMY AND SURGICAL PRACTICE IN CASE OF VENOUS BLEEDING AT THE LEVEL OF THE PONTOCEREBELLAR ANGLE Mihaela HOROI, Serban V. BERTESTEANU, Bogdan POPESCU, Raluca GRIGORE, Marie-Paule THILL ...... 571

MINIREVIEW

THE ROLE OF SENTINEL LYMPH NODE DETECTION IN EARLY GASTRIC CANCER – LITERATURE REVIEW Nicolae BACALBASA, Irina BALESCU, Cristian BALALAU, Mihaela VILCU, Iulian BREZEAN ...... 576 VALUE OF SENTINEL NODE BIOPSY IN ANAL CANCER PATIENTS Nicolae BACALBASA, Irina BALESCU, Cristian BALALAU, Mihaela VILCU, Iulian BREZEAN ...... 581

CASE REPORT

TWO CLINICAL CASES OF MODERN POSTOPERATIVE TREATMENT OF A 3RD DEGREE SKIN BURN WITH THERESIENÖL Strahil A. STRASHILOV, Angel D. YORDANOV, Polina P. VASILEVA ...... 585 SURGICAL APPROACH OF INFECTED MESH WITH ENTERO-ATMOSPHERIC FISTULA – A CASE PRESENTATION Daniel I. MIHALACHE, Bogdan SOCEA, Alexandru C. SMARANDA, Anca A. NICA, Alexandru C. CARAP, Ovidiu G. BRATU, Ana Maria A. STANESCU, Florin GROSEANU, Mihai C.T. DIMITRIU, Vlad D. CONSTANTIN ...... 591 ARCHIVES OF THE BALKAN MEDICAL UNION Instructions to authors ...... 597