Page 1 of 42 Diabetes
Hypothalamic orexin prevents hepatic insulin resistance via daily
bidirectional regulation of autonomic nervous system in mice
Hiroshi Tsuneki,1 Emi Tokai,1 Yuya Nakamura,1 Keisuke Takahashi,1 Mikio Fujita,1
Takehiro Asaoka,1 Kanta Kon,1 Yuuki Anzawa,1 Tsutomu Wada,1 Ichiro Takasaki,2
Kumi Kimura,3 Hiroshi Inoue,3 Masashi Yanagisawa,4,5 Takeshi Sakurai,6 and Toshiyasu
Sasaoka1
1Department of Clinical Pharmacology, 2Division of Molecular Genetics Research, University
of Toyama, 2630 Sugitani, Toyama 930 0194, Japan.
3Frontier Science Organization, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan.
4Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas
Southwestern Medical Center, Dallas, Texas 75390, U.S.A.
5Center for Behavioral Molecular Genetics, University of Tsukuba, Tsukuba, Ibaraki 305
8575, Japan.
6Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine,
Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan.
Short running title: Regulation of metabolic rhythm by orexin
Corresponding Author: Hiroshi Tsuneki, Ph.D. or Toshiyasu Sasaoka, M.D., Ph.D.
Tel.: +81 76 434 7550, Fax: +81 76 434 5067, E mail: [email protected]