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C. V. Alice Shih-hou Huang, Ph.D. Sr. Faculty Associate in Biology & Biological Engineering California Institute of Technology

Office Address: Mail Code 156-29 TEL 626 395 3446 California Institute of Technology FAX 626 395 3323 Pasadena, CA 91125 [email protected]

Home Address: 1225 South Grand Avenue TEL 626 799 0173 Pasadena, California 91105-2835 CELL 626 840 7099

Place of Birth: Nanchang, Jiangxi, China; US citizen

Marital Status: Married, 1 child

Education: 1957-59 Wellesley College, Wellesley, MA (Freshman Honors) 1961 B.A. (Human Biology), , School of Medicine, , MD 1963 M.A., Johns Hopkins School of Medicine, Department of Microbiology 1966 Ph.D., Johns Hopkins School of Medicine, Department of Microbiology

Postdoctoral Training: 1967 Postdoctoral Fellow, The Salk Institute for Biological Studies, San Diego, CA 1968-69 Postdoctoral Fellow, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 1969-70 Research Associate, Department of Biology, Massachusetts Institute of Technology

Academic Appointments: 1971-73 Assistant Professor of Microbiology and Molecular Genetics (now Microbiology and Immunobiology, Harvard Medical School, and Faculty of Arts and Sciences, Harvard University (Silas Arnold Houghton Assistant Professor, 1971-72), Boston, MA 1973-78 Associate Professor of Microbiology and Molecular Genetics, Harvard Medical School 1979-91 Professor of Microbiology and Molecular Genetics, Harvard Medical School 1991-97 Dean for Science and Professor of Biology, New York University, New York, NY 1997-06 Senior Councilor for External Relations and Faculty Associate in Biology, California Institute of Technology, Pasadena, CA 2006-12 Senior Faculty Associate in Biology & Biological Engineering, California Institute of Technology, Pasadena, CA

Hospital Appointments: 1971-73 Scientific Associate, Channing Laboratory and Department of Medical Microbiology, Department of Medicine, Harvard Unit, Boston City Hospital, Boston, MA 1979-90 Director, Laboratories of Infectious Diseases, Children's Hospital, Boston, MA

Other Professional Positions and Major Visiting Appointments: 1966 Visiting Assistant Professor (1 semester), Academia Sinica and National Taiwan University, Taipei, Taiwan 1970 Lecturer (2 mo), Academia Sinica, Taiwan 1975-76 Visiting Associate Professor of Virology, , New York, NY 1979-91 Professor of Microbiology in Health Sciences and Technology (Secondary appointment in the Harvard-MIT Program)

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1980 Wellcome Visiting Professorship in the Basic Medical Sciences (2 wks), University of Mississippi 1989 Faculty Member, Summer Science Seminar (2 wks), Japanese Association of Mathematical Sciences 1998-03 Visiting Scholar, Dept. of Biology, New York University

Awards, Honors, Honorary Degrees etc: 1958 Academic Honors, Wellesley College, Wellesley, MA 1960-61 Opportunity Fellow, John Hay Whitney Foundation, New York 1975-76 American Society for Microbiology Foundation Lecturer 1977 Eli Lilly Award in Microbiology and Immunology 1978 Alumnae Citation Award, National Cathedral School, Washington, D.C. 1979 Burroughs Wellcome Traveling Fellow to Great Britain 1980 M.A. (Honorary) Harvard University 1982 Doctor of Science (Honorary), Wheaton College, MA 1987 Doctor of Science (Honorary), Mount Holyoke College, MA 1989 San Francisco Chinese Hospital Annual Award 1989 Sigma Delta Epsilon, Women in Science (honorary) 1989-94 NIH Merit Award 1991 Doctor of Science (Honorary), Medical College of Pennsylvania, Philadelphia, PA. 1990 Member, Academia Sinica, Taiwan 1994 NY-American Women in Science (AWIS) Award for Outstanding Woman Scientist 1997 Phi Tau Phi Scholastic Honor Society of America (West American Chapter) 1998 Fellow of the Association for Women in Science 1998 Honorary Alumna of the California Institute of Technology 1999 Achievement Award of the Chinese-American Faculty Association of Southern California 1999 Renantanda Alice Shih-hou Huang (Renanthera Kalsom x Vanda insignis), orchid named by the Botanical Gardens, National Parks Board, Singapore 2000 Fellow, American Association for the Advancement of Science 2001 Alice C. Evans Award, American Society for Microbiology 2009 Carnegie Foundation’s Great Immigrants: Pride of America honoree 2012 Asian American Engineer/Scientist of the Year Lifetime Achievement Award given by the Chinese Institute of Engineers – USA 2013 Award from the Chinese-American Engineers and Scientists Association of Southern California 2015 The Johns Hopkins University School of Medicine Distinguished Alumnus/Alumna Award

Named Lectureships: 1977-78 American Society for Microbiology Foundation Lecturer 1981 The Sixth Hattie Alexander Memorial Lecturer, , New York 1985 Lee Kuan Yew Distinguished Visitor, National University of Singapore 1986 Sophie Jones Lecturer, Department of Medicine, University of Michigan, Ann Arbor 1987 Carl G. Harford Visiting Professor in Infectious Diseases, Washington University, St. Louis. MO 1988 Orton K. Stark Lecturer (24th), Miami U., Oxford, Ohio 2013 Annual Bernadine Healy Lectureship, Cleveland Clinic, Cleveland, Ohio 2014 Annual Wang Ying-lai Memorial Lecture, U. of Texas Med. Branch, Galveston, TX

Funding History: 1972-77 Research Career Development Award, U.S. Public Health Service 1971-94 NIH RO1 grant on Replication of Vesicular Stomatitis Virus (Merit Award 1989- 1994; voluntarily terminated in 1994) 1971-90 Preceptor to postdoctoral fellows supported by the Damon-Runyan Foundation, Amer. Cancer Soc., Helen Hay Whitney Foundation, WHO, Eleanor Roosevelt- NATO Foundation, Jane Coffin Childs Foundation and the NIH 1973-98 P.I. on miscellaneous small grants to support scientific meetings, i.e. Gordon

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Conference, Retirement Conferences, etc. 1971-81 P.I. on ACS research grant on Replication of Vesicular Stomatitis Virus 1974-77 Co-P.I. on NSF program grant on Differentiated Membrane Assembly and Interactions (with Dan Goodenough as P.I.) 1975-90 Program Director of NIH-NCI Institutional National Research Service Award (training grant) on Virus-Host Interactions in Cancer to support pre- and postdoctoral fellows 1984-87 Director of the Center for Pediatric Viral Diseases as part of the Program on Great Neglected Diseases supported by the Rockefeller Foundation 1992 NSF grant to support a symposium at NYU on Science and Math Education 1992-97 EPA infrastructure and equipment grants to NYU 1993-94 NSF Collaborative for Excellence in Teacher Preparation - a Planning grant 1994-97 Co-PI on HHMI Award to support Undergraduate Education 1995-00 Co-PI, NSF-supported Collaborative for Excellence in Teacher Preparation (joint with the NYU School of Education and with 5 CUNY campuses) 1996-98 Co-PI, NSF-supported University-wide Curriculum Development Grant 1996-97 P.I., HHS-OPRR grant for the Renovation of Research Animal Facility 1997 P.I., HHS-OPRR grant for the Renovation of a Primate Animal Facility 1997 P.I., Keck Foundation Award for Support of Neuroscience Research Facility 1997 P.I., HHMI Award for Vivarium Renovations at NYU 2001-4 P.I., Annenberg Foundation for Science Curriculum Development for Schools at Caltech

Professional Memberships & Honor Societies: 1966 Sigma Xi Honor Society, Johns Hopkins Chapter 1967 American Society for Microbiology (fellow, American Academy of Microbiology) 1971 American Association for the Advancement of Science (fellow, ‘00) 1974 American Society for Biochemistry and Molecular Biology 1978 Association of Women in Science (fellow) 1979 Infectious Diseases Society of America (fellow) 1981 American Society for Virology 1982 American Academy of Microbiology 1988 Society of Chinese Bioscientists of America 1990 Academia Sinica, Taiwan 1990 New York Academy of Sciences 1994 Marine Biology Laboratory Corporation, Woods Hole, MA

National and International Committee Assignments and Meeting Chairmanships Related to Science: 1973-77 Virology Study Section, National Institutes of Health 1976-77 Advisory Board Member to the Yale Virology Group 1976-77 Virology Task Force, NIH-NIAID, Vice Chairman of Panel IV 1976 Co-chairman and Co-editor, ICN-UCLA Symposium on Molecular and Cell Biology, ANIMAL VIROLOGY, Academic Press, NY 1977 Co-chairman, Gordon Conference on Animal Cells and Viruses 1979-82 Microbiology and Infectious Diseases Advisory Committee, NIH-NIAID 1981 Vice Chairman, Program Committee, Vth International Congress of Virology 1981-85 Yale University Council Committee on Biological Sciences 1982-85 Award Committee for the Eli Lilly and Company Award in Microbiology and Immunology 1982-92 Council Member, International Congress for Infectious Diseases 1983-91 Member, Board of Directors, The National Foundation for Infectious Diseases 1983,85-87 Member, Viral & Rickettsial Diseases Review Panel, U.S. Army Medical Research

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and Development Command 1983 Member, Ad hoc Advisory Committee of the Central Laboratory of Molecular Biology, National Science Council, Taiwan 1984-85 Member, Ad hoc Subcommittee on Infectious Diseases for the Institute of Biomedical Sciences, National Science Council, Taipei, Taiwan 1985-87 Ad Hoc Advisory Committee on the Biological Sciences at Wellesley College 1986-87 Search Committee for Director of the Marine Biological Laboratories, Woods Hole, MA. (Member) 1986-13 Trustee, Waksman Foundation for Microbiology, New York (Vice President, 88-93; Chair, 93-01) 1987-89 Committee on Nominations, American Association for the Advancement of Science 1988-89 President, American Society for Microbiology 1988-92 Symposium Organizing Committee, International Symposia: Society of Chinese Bioscientists of America (in Hong Kong, 1990 in Singapore, 1992) 1989-91 Chair, Retroviral Diseases Peer Review Panel to the US Army Medical Research Development Command for the American Institute of Biological Science 1989-93 Member, U.S. Army Medical Research and Development Command Advisory Committee, Office of the Surgeon General 1989-90 Scientific Advisor, Biotechnology Center, The Chinese University of Hong Kong 1989-92 Member, Scientific Advisory Board, Tampa Bay Research Institute, Teikyo-Showa Universities Center, St. Petersburg, FL, USA 1990-93 Scientific Advisory Committee Member, Children's National Medical Center, Washington, DC. (Chair 1993) 1990-92 Member, Advisory Council, Arnold and Mabel Beckman Center for Molecular Genetic Medicine, Stanford University, Stanford, CA 1991-92 Member, Lewis Thomas Award Committee (for excellence in communicating life sciences), Marine Biology Laboratories, Woods Hole, MA 1991-94 Member, Scientific Advisory Board, Cutaneous Biology Research Center, Department of Dermatology, Harvard Medical School & Massachusetts General Hospital, Boston, MA

National and International Committee Assignments and Meeting Chairmanships Related to Science cont: 1984-03 Scientific Advisor, Institute of Molecular and Cell Biology (IMCB), National University of Singapore (Chair, Scientific Board 1998-2002; Chair, Search Committee for a Director 2001) 1994-07 Academic Advisory Committee, Institute of Molecular Biology (IMB), Academia Sinica, Taiwan 1994-95 Chair, Committee to select the Abbott-ASM Lifetime Achievement Awardee 1995-98 Member, Selection Committee for the 1995 ICN International Prize in Virology 1996-98 Chair, Committee to select the ASM Distinguished Service Award 1997-00 Councilor, Society of Chinese Bioscientists of America 1997-01 Member, Board of Directors, American Association for the Advancement of Science 1997-01 Member, Vaccines and Related Biological Products Advisory Committee, Food and Drug Administration 1998-01 Chair, ASM Task Force on Governance 1999 Chair, AAAS Search Committee for the Editor of Science 1999-01 Member, Advisory Committee, Education and Human Resources Directorate, NSF 2000-01 Member, Astrobiology Task Force of the Space Science Advisory Committee, NASA 2000-04 Member, Committee on Women in Science & Engineering, NRC-NAS 2002-03 Member, Search Committee for the Director of the Astrobiology Institute, NASA 2002-03 Member, Board of the Agency for Science, Technology, and Research (A*STAR, formerly Nat'l Science and Technology Board) and the Science and Engineering Research Council (SERC), Singapore

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2002-05 Member, Scientific Advisory Board, National Institute of Biological Sciences (NIBS), Beijing, China 2003-05 Chair, International Science Panel on SARS, Agency of Science, Technology, and Research (A*STAR), Singapore 2003-06 Deputy Chairman, A*STAR Graduate Academy (A*GA, advisory), Singapore 2005-06 Member, AAAS Nominating Committee 2005-06 Member, Ames Executive Forum (Advisory), NASA Ames Research Center 2008- Member, Chair 2009 - 2012; Advisory Council of the Institute for Basic Biomedical Sciences, Johns Hopkins University, School of Medicine, Balltimore, MD. 2008- Member, Board of the Rosalind Franklin Society, New York. 2010-11 President, American Association for the Advancement of Science 2010-15 Member, Review Board, Harvard Medical School-Portugal Program. 2011-12 Chair of the Board, American Association for the Advancement of Science 2011-15 Member, Selection Committee, the Eli Lilly and Company Research ,‐ ElancoASM Award 2011 Member, Visiting Committee, Johns Hopkins University 2011-13 Member, Review Board for the Joint Keck Science Program for Claremont McKenna, Pitzer, and Scripps Colleges

Editorial Boards: 1973-90 Intervirology--Editorial Board Member 1975-78 Archive of Virology--Editorial Board Member 1976-93 J. Virology--Editorial Board Member 1978-89 Reviews of Infectious Diseases--Associate Editor 1982 ASM News--Editorial Board Member 1985-90 Microbial Pathogenesis--Editorial Board Member 1992-00 Journal of Women's Health--Editorial Board Member

California Institute of Technology related committees: 1997- Member, Athenaeum Wine Committee 2001-11 Member, Advisory Board of the Edythe and Eli Broad Foundation on Inflammatory Bowel Disease 2003-10 Member, Director’s Advisory Council, Jet Propulsion Laboratory, La Canada, CA 2004-09 Member, California Council for Science and Technology, Sacramento, CA 2007-12 Chair, Institutional Animal Care and Use Committee 2007- Faculty member responsible for Bi23 tutorials

Ad hoc Reviews of Grant Applications, Manuscripts, and Programs: 1971-1999 National Science Foundation, Atomic Energy Commission, American Cancer Society, Communicative Disorders and Stroke, N.Y. State Health Agency, US-Israel Binational Science Foundation, U.S. Veteran's Administration, Prentice-Hall, Swiss National Research Council, Regents of the Board of Education of New York Commission, Massachusetts AIDS Research Council, Damon Runyon-Walter Winchell Cancer Fund, Cancer Research Institute, New England Journal of Medicine, Singapore Economic Development Corporation, Proceedings of the National Academy of Sciences, 2000-present Howard Hughes Medical Institute, University of Massachusetts, Hunter College, Cal State Polytechnic Pomona, Singapore National Science Foundation, Swedish Foundation for Strategic Research, Riken Institute –Japan, MacArthur Foundation

Community Service: 1976-77 National Commission on Smoking and Public Policy, American Cancer Society (Member) 1983-86 Board of Directors, Massachusetts Division of the American Cancer Society 1987-91 Trustee, University of Massachusetts, Gubernatorial Appointment 1987-89 Board of Overseers, Shady Hill School, Cambridge, MA (Member) 1991-95 Member, Alumnae Board of Visitors, National Cathedral School, Washington, DC, Emeritus member, 1995 1992-04 Trustee, Johns Hopkins University 1993-97 Member, Council of the Johns Hopkins University-Nanjing University Center for

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Chinese and American Studies 1993-99 Trustee, Board of Trustees of The Keystone Center, Keystone, CO 1995-98 Science Writing Fellowship Program Advisory Committee, Marine Biology Laboratories, Woods Hole, MA (Member) 1996-97 Board of Overseers' Visiting Committee to the Harvard School of Public Health (Member). Boston, MA 1997 Lifetime Member, The Associates of the California Institute of Technology 1996-05 Member, Board of Directors, Health Effects Institute, Boston, MA 1998-07 Sustaining Member, League of Women Voters Pasadena Branch 1998-07 Sustaining Member, YWCA Pasadena-Foothill Valley 1998-06 Honorary Member, ARCS 1998-06 Trustee, The Keck Graduate Institute of Applied Life Sciences, Claremont, CA Emeritus member, 2006 - 1998- Member, The Pacific Council on International Policy, Los Angeles 1999- Member, Blue Ribbon, Los Angeles Music Center; board 1999-06 Honorary Member, Pasadena Senior Center 2001-12 Member, Board of Directors, Public Agenda, New York, NY 2004-14 Trustee, Rockefeller Foundation, New York, NY 2009-12 Board Member, 80-20 Initiative for Asian Americans 2007-11 Committee of 100; Board member 2008-2010; resigned 2011 2011-15 Council member, Advisory Council to the Wellesley Centers on Women, Wellesley College, MA.

Industrial Relations: 1969 Patent for Defective Interfering Particles (M.I.T.) 1973-74 Scientific Advisor, Biotech, Inc. (Rockville, MD) 1977 Patent for SABA (Surface Assay for Bacterial Adherence; Harvard Medical School) 1983-88 Director, Children's Hospital Peptide Synthesis Facility-self supporting 1988-90 Scientific Advisor, Diagnostic Biotech (PTE), Ltd., Singapore 1996-00 Director, GeneSing, Singapore

Publications (abstracts not included):

1. Huang, AS and Wagner, RR: Penetration of herpes simplex virus in human epidermoid cells. Proc. Soc. Exptl. Biol. Med. 116:863-869, 1964. 2. Wagner, RR and Huang, AS: Reversible inhibition of interferon synthesis by puromycin: evidence for an interferon-specific messenger RNA. Proc. Natl. Acad. Sci. USA 54:1112-1118, 1965. 3. Huang, AS and Wagner, RR: Inhibition of cellular RNA synthesis by non-replicating vesicular stomatitis virus. Proc. Natl. Acad. Sci. USA 54:1579-584, 1965. 4. Wagner, RR and Huang, AS: Inhibition of RNA and interferon synthesis in Krebs-2 cells infected with vesicular stomatitis virus. Virology 28:1-10, 1966. 5. Huang, AS, Greenawalt, JW, and Wagner, RR: Defective T particles of vesicular stomatitis virus I. Preparation, morphology and some biological properties. Virology 30:161-172, 1966. 6. Huang, AS and Wagner, RR: Defective T particles of vesicular stomatitis virus II. Biologic role in homologous interference. Virology 30:173-181,1966. 7. Huang, AS and Wagner, RR: Comparative sedimentation coefficients of RNA extracted from plaque- forming and defective particles of vesicular stomatitis virus. J. Mol. Biol. 22:381-384, 1966. 8. Baltimore, D and Huang, AS: Isopycnic separation of subcellular components from poliovirus- infected and normal HeLa cells. Science 162:572-574, 1968. 9. Stampfer, M, Baltimore, D and Huang, AS: Ribonucleic acid synthesis of vesicular stomatitis virus I. Species of RNA in CHO cells infected with plaque-forming and defective particles. J. Virol. 4:154-161, 1969. 10. Baltimore, D and Huang, AS: Interaction of HeLa cell proteins with RNA. J. Mol. Biol. 47:263-273, 1970. 11. Huang, AS and Baltimore, D: Initiation of polyribosome formation in poliovirus-infected HeLa cells.

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J. Mol.Biol. 47:275-291, 1970. 12. Baltimore, D, Jacobson, MF, Asso, J and Huang, AS: The formation of poliovirus proteins. Cold Spring Harbor Symp. Quant. Biol. 34:741-746, 1969. 13. Huang, AS and Baltimore, D: Defective viral particles and viral disease processes. Nature 226:325- 327, 1970. 14. Burge, BW and Huang, AS: Comparison of membrane protein glycopeptides of Sindbis virus and vesicular stomatitis virus. J. Virol. 6:176-182, 1970. 15. Baltimore, D, Huang, AS and Stampfer, M: Ribonucleic acid synthesis of vesicular stomatitis virus II. An RNA polymerase in the virion. Proc. Natl. Acad. Sci. USA 66:572-576, 1970. 16. Huang, AS, Baltimore, D and Stampfer, M: Ribonucleic acid synthesis of vesicular stomatitis virus III. Multiple complementary messenger RNA molecules. Virology 42:946-957, 1970. 17. Stampfer, M, Baltimore, D and Huang, AS: Absence of interference during high multiplicity infection by clonally purified vesicular stomatitis virus. J. Virol. 7:409-411, 1971. 18. Huang, AS, Baltimore, D and Bratt, MA: Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase. J. Virol. 7:389-394, 1971. 19. Baltimore, D, Huang, AS, Manley, KF, Rekosh, D and Stampfer, M: The synthesis of protein by mammalian RNA viruses. CIBA Fdn. Symp. on Strategy of the Viral Genome, G.E.W. Wolstenholme & M. O'Connor (eds), 1971, pp. 101-110. 20. Stampfer, M, Rosbash, M, Huang, AS and Baltimore, D: Complementarity between messenger RNA and nuclear RNA from HeLa cells. Biochem. Biophys. Res. Commun. 49:217-224, 1972. 21. Huang, AS and Manders, EK: Ribonucleic acid synthesis of vesicular stomatitis virus IV. Transcription by standard virus in the presence of defective interfering particles. J. Virol. 9:909-916, 1972. 22. Manders, EK, Tilles, JG and Huang, AS: Interferon-mediated inhibition of virion-directed transcription. Virology 49:573-581, 1972. 23. Soria, M and Huang, AS: Association of poly(A) with messenger RNA of vesicular stomatitis virus. J. Mol. Biol. 77:449-455, 1973. 24. Huang, AS: Defective interfering viruses. Ann. Rev. Microbiol. 27:101-117, 1973. 25. Huang, AS, Besmer, P, Chu, L and Baltimore, D: Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses. J. Virol. 12:659-662, 1973. 26. Huang, AS: The molecular biology of a defective virus. In Viral Replication and Cancer, J.L. Melnick, S. Ochoa, and J. Oro (eds), Editorial Labor, S.A., Barcelona, 1973, pp. 95-104. 27. Perlman, SM and Huang, AS: Transcription and replication of vesicular stomatitis virus RNA. In Virus Research, C.F. Fox and W.S. Robinson (eds), Academic Press, 1973, pp. 97-103. 28. Perlman, SM and Huang, AS: Ribonucleic acid synthesis of vesicular stomatitis virus V. Interactions between transcription and replication. J. Virol. 12:1395-1400, 1973. 29. Palma, EL and Huang, AS: Cyclic production of vesicular stomatitis virus caused by defective interfering particles. J. Infect. Dis. 129:402-410, 1974. 30. Palma, EL, Perlman, SM and Huang, AS: Ribonucleic acid synthesis of vesicular stomatitis virus VI. Correlation of defective particle RNA synthesis with standard RNA replication. J. Mol. Biol. 85:127-136, 1974. 31. Perlman, SM and Huang, AS: Virus-specific RNA specified by the group I and IV temperature- sensitive mutants of vesicular stomatitis virus. Intervirol.2:312-325,1974. 32. Soria, M, Little, SP and Huang, AS: Characterization of vesicular stomatitis virus nucleocapsids I. Complementary 40S RNA molecules in nucleocapsids. Virol. 61:270-280, 1974. 33. Huang, AS and Palma, EL: Vesicular stomatitis virus: defectiveness and disease. In Virus Research, W.S. Robinson and P.H. Duesberg (eds), Academic Press, NY, 1974, pp. 87-99. 34. Kashket, ER, Robbins, ML, Leive, L and Huang, AS: Status of women microbiologists. Science 183:488-494, 1974. 35. Huang, AS, Palma, EL, Hewlett, N and Roizman, B: Pseudotype formation between enveloped RNA and DNA viruses. Nature New Biol. 252:743-745, 1974. 36. Huang, AS: Ribonucleic acid synthesis of vesicular stomatitis virus. In Negative Strand Viruses, R.D. BARRY AND B.W.J. Mahy (eds), Academic Press, NY, 1975, pp.353-359.

37. Huang, AS, Besmer, P and Baltimore, D: Use of pseudotypes of vesicular stomatitis virus to study cellular resistance to murine RNA tumor viruses. Proc. NATO Adv. Study Inst., Tumor Virus-Host Cell Interaction, A. Kolber (ed), Plenum Publishing Corp., NY, 1975, pp. 331-336.

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38. Huang, AS and Palma, EL: Defective interfering particles as antiviral agents. In Perspectives in Virology IX, M. Pollard (ed), Academic Press, NY, 1975, pp. 77-90. 39. Huang, AS and Hewlett, N: Pseudotype formation between herpes simplex virus and RNA viruses. In Proc. III Internati'l Cong. Comparative Leukemia, 1976. 40. Sinarachatanant, P and Huang, AS: Effects of temperature and antibody on the cyclic growth of vesicular stomatitis virus. J. Virol. 21:161-167, 1976. 40a Huang, AS: Viral Pathogeneis and Molecular Biology, Bacteriol. Rev. 41:811-821, 1977. 41. Freeman, GJ, Rose, JK, Clinton, GM and Huang, AS: Ribonucleic acid synthesis of vesicular stomatitis virus VII. Complete separation of the messenger RNA's of VSV by duplex formation. J. Virol. 21:1094-1104, 1977. 42. Huang, AS and Baltimore, D: Defective interfering animal viruses. In Comprehensive Virology, Vol. 10, H. Fraenkel-Conrat and R.R. Wagner (eds), Plenum Publishing Corp., N.Y., 1977, pp. 73-116. 43. Little, SP and Huang, AS: Synthesis and distribution of vesicular stomatitis virus proteins in the absence of progeny production. 81:73-74, 1977. 44. Freeman, GJ, Rao, DD and Huang, AS: Genome organization of vesicular stomatitis virus: mapping of ts G41 and the defective interfering T particle. In Negative Strand Viruses and the Host Cell, B.W.J. Mahy and R.D. Barry (eds), Academic Press, N.Y., 1977, 261-270. 46. Clinton, GM, Burge, BW and Huang, AS: Effects of phosphorylation and pH on the association of NS protein with vesicular stomatitis virus cores. J. Virol. 27:340-346, 1978. 47. Little, SP and Huang, AS: Shedding of the glycoprotein from vesicular stomatitis virus-infected cells. J. Virol. 27:330-339, 1978. 48. Clinton, GM, Little, SP, Hagen, FS and Huang, AS: The matrix (M) protein of vesicular stomatitis virus regulates transcription. Cell 15:1455-1462, 1978. 49. Huang, AS, Little, SP, Oldstone, MBA and Rao, D: Defective interfering particles: their effect on gene expression and replication of vesicular stomatitis virus. In ICN-UCLA Symp. of Persistent Viruses, G. Todaro, J. Stevens, and C.F. Fox (eds), Academic Press, N.Y., 1978, pp. 399-408. 50. Huang, AS and Okorie, TG: Rapid viral diagnosis using surface analysis by bacterial adherence. Lancet, Nov. 25, 1978, p. 1146. 51. Freeman, GJ, Rao, DD and Huang, AS: RNA synthesis of vesicular stomatitis virus VIII. Oligonucleotides of the structural genes and RNA. Gene 5:141-157, 1979. 52. Burge, BW and Huang, AS: Conserved peptides in the proteins of vesicular stomatitis virus. Virology 95:445-453, 1979. 53. Huang, AS and Okorie, TG: Surface analysis by bacterial adherence to virus-infected cells. J. Infect. Dis. 140:147-151, 1979. 54. Rao, DD and Huang, AS: Synthesis of a small RNA in cells co-infected by standard and defective interfering particles of vesicular stomatitis virus. Proc. Natl. Acad. Sci. USA 76:3742-3745, 1979. 55. Clinton, GM, Burge, BW and Huang, AS: Phosphoproteins of VSV: Identity and interconversion of phosphorylated forms. Virology 99:84-94, 1979. 56. Rao, DD and Huang, AS: RNA synthesis of vesicular stomatitis virus X. Transcription and replication by defective interfering particles. J. Virol. 36:756-765, 1980. 57. Reichmann, ME, Bishop, DHL, Brown, F, Crick, J, Holland, JJ, Kang, C-Y, Lazzarini, R, Moyer S, Perrault, J, Prevec, L, Pringle, CR, Wagner, RR, Youngner, JS and Huang, AS: Proposal for a uniform nomenclature for defective interfering viruses of vesicular stomatitis virus. J. Virol. 34:792-794, 1980. 58. Huang, AS, Rao, DD and Lanman, G: Defective interfering particles of vesicular stomatitis virus: Structure-function relationships. Ann. N.Y. Acad. Sci. 354:238-250, 1980. 59. Huang, AS and Pringle, CR: Workshop on rhabdoviruses and paramyxoviruses. In ICN-UCLA Symp. on Animal Virus Genetics, B. Fields, R. Jaenisch, and C.F. Fox (eds), Academic Press, N.Y., 1980, pp. 811-813. 60. Huang, AS: Viral glycoproteins: Introduction. Rev. Infect. Dis. 2:24-25, 1980. 61. Clinton, GM and Huang, AS: Phosphoproteins of vesicular stomatitis virus and of the host cell. Proc. Juselius Symp. on "Expression of eukaryotic viral and cellular genes," Helsinki, 1981. Academic Press, NY, pp. 163-171. 62. Hagen, FS and Huang, AS: Comparison of ribonucleotide sequences from the genome of vesicular stomatitis virus and two of its defective interfering particles. J Virol. 37:363-371, 1981. 63. Clinton, GM and Huang, AS: Distribution of phosphoserine, phosphothreonine and phosphotyrosine in proteins of vesicular stomatitis virus. Virology 108:510-514, 1981. 64. Huang, AS: The molecular biology of vesicular stomatitis virus and its defective interfering particles.

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In The Role of RNA in Development and Reproduction, M.C. Niu and H.H. Chuang (eds), Science Press, Beijing, China, 1981, pp. 313-322. 65. Freeman, GJ and Huang, AS: Mapping temperature-sensitive mutants of vesicular stomatitis virus by RNA heteroduplex formation. J. Gen. Virol. 57:103-117, 1981. 66. Huang, AS: Virology. In Highlights in Microbiology 1979-80, R.L. Moon and D.D. Whitt (eds), American Society for Microbiology, Washington, D.C., 1981, pp. 32-33. 67. Rao, DD and Huang, AS: Interference among defective interfering particles of vesicular stomatitis virus. J. Virol. 41:210-221, 1982. 68. Clinton, GM, Guerina, NG, Guo, H-Y and Huang, AS: Host-dependent phosphorylation and kinase activity associated with vesicular stomatitis virus. J. Biol. Chem. 257:3313-3319, 1982. 69. Huang, AS: Persistent viral infections: Introduction. Rev. Inf. Dis. 4:998, 1982. 70. Huang, AS: Rhabdoviruses. In Medical Microbiology, S. Baron (ed), Addison-Wesley Publishing Co., Menlo Park, CA, 1982, pp. 661-665. 71. O'Rourke, EJ, Guo, H-Y and Huang, AS: Antibody-induced modulation of proteins in vesicular stomatitis virus-infected fibroblasts. Mol. Cell. Biol. 3:1580-1588, 1983. 72. Little, LM, Lanman, G and Huang, AS: Immunoprecipitating human antigens associated with vesicular stomatitis virus grown in HeLa cells. Virology 129:127-136, 1983. 73. Little, LM, Zavada, J, Der, CJ and Huang, AS: Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen. Science 220:1069-1071, 1983. 74. Huang, AS, O'Rourke, EJ and Little, LM: Viral glycoproteins at the cell surface. In Biochemical and Biophysical Studies of Proteins and Nucleic Acids, T.B. Lo, T.Y. Liu, and C.H. Li, (eds), Elsevier Inc., N.Y. 1984, pp. 61-68. 75. Cave, DR, Hagen, FS, Palma, EL and Huang, AS: Detection of the RNA of vesicular stomatitis virus and its defective interfering particles in individual mouse brains. J. Virol. 50:86-91, 1984. 76. Ehrnst, AC and Huang, AS: Dyad-symmetry in VSV RNA may determine the availability of the RNA- polymerase binding site. In Nonsegmented Negative Strand Viruses, D.H.L. Bishop and R.W. Compans (eds), Academic Press, Inc., N.Y., 1984, pp. 87-94. 77. Zavada, J and Huang, AS: Further characterization of proteins assembled by vesicular stomatitis virus from human tumor cells. Virol. 138:16-25, 1984. 78. Wu, T-Y, Yilma, T and Huang, AS: Correlation between virulence of vesicular stomatitis virus isolates and continued high titers during undiluted passage. Proc. Internat. Conf. on Vesicular Stomatitis, Mexico City, U.S. Commission for the Prevention of Foot and Mouth Disease, Sept. 22-24, 1984. 79. Huang, As and Modlin, JF: RNA viruses: Picornaviridae (Introduction). In Principles and Practice of Infectious Diseases, 2nd ed, G.L. Mandell, R.G. Douglas, J.E. Bennett (eds), Wiley and Sons, New York, 1985, pp. 800-806. 80. Cave, DR, Hendrickson, FM, Huang, AS: Defective interfering virus particles modulate virulence. J. Virol. 55:366-373, 1985. 81. Zullo, JN, Cochran, BH, Huang, AS and Stiles, CD: Platelet-derived growth factor and double- stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell 43:793-800, 1985. 82. Huang, AS, Wu, TY, Yilma, T and Lanman, G: Characterization of virulent isolates of vesicular stomatitis virus in relation to interference by defective particles. Microbial Pathogenesis 1:205-215, 1986. 83. Toltzis, PH and Huang, AS: Effect of ribavirin on macromolecular synthesis in vesicular stomatitisvirus-infected cells. Antimicrobial Agents and Chemotherapy 29:1010-1016, 1986. 84. Reiss, CS, Chen, SL, Huang, AS and Doherty, R: VSV G protein induces murine cytolytic T lymphocytes. Microbial Pathogenesis 1:261-267, 1986. 85. Chen, SSL and Huang, AS: Further characterization of the vesicular stomatitis virus ts 045 mutant: Intracellular conversion of the glycoprotein to a soluble form. J. Virol. 59:210-215, 1986. 86. Burns, JC, Geha, RS, Schneeberger, EE, Newburger, JW, Rosen, F, Glezen LS, Huang AS, Natale, J and Leung, DYM. Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. Nature 323:814-816, 1986. 87. Huang, AS and Boni, J: Genetic engineering of antiviral agents. Antimicrobial Agents and Chemotherapy 31:1293-1295, 1987. 88. Huang, AS: The role of defective interfering (DI)particles in viral infection. In The Molecular Basis of Viral Replication (NATO ASI series), R. Perez Bercoff (ed), Plenum Press, New York, 1987, pp. 191-194. 89. Chen, SSL, Doherty, R, O'Rourke, EJ, Ariel, N and Huang, AS: Effect of transport inhibitors on the generation and transport of a soluble viral glycoprotein. Virology 160:982-984, 1987. 90. Huang, AS: Modulation of viral diseases by defective interfering particles in RNA Genetics:

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Variability of RNA Genomes, eds: E. Domingo, J.J. Holland, P. Ahlquist, CRC Press, Boca Raton, FL, pp. 195-208, 1988. 91. Chen, SSL, Ariel, N and Huang, AS: Membrane anchors of vesicular stomatitis virus: Characterization and incorporation into virions. J. Virol. 62:2552-2556, 1988. 92. Chen, SSL, and Huang, AS: Human cervical carcinoma cell lines contain an antigen identical to the tumor-specific 75 KDa antigen of HeLa cells: detection by viral acquisition, J. Virol. Methods, 24:159-168, 1989. 93. Fan, W, Chen, SSL, and Huang, AS: Multiple thermolabile and temperature-sensitive lesions in mutant tl17 of vesicular stomatitis virus. Intervirol. 30:148-155, 1989. 94. Zhu, Z, Chen, SSL, and Huang, AS: Phenotypic Mixing between human immunodeficiency virus and vesicular stomatitis virus or herpes simplex virus. J. Acquired Immunodeficiency Syndromes, 3:215-219, 1990. 95. Burns, JC, Huang, AS, Newburger, JW, Reinhart, AL, Walsh, MM, Hoch, S, Leung, DYM: Characterization of the polymerase activity associated with cultured peripheral blood mononuclear cells from patients with Kawasaki Disease. Ped. Res., 27:109-112, 1990. 96. Krivine, A, Yakudima, A., LeMay, M., Pena-Cruz, V, Huang, AS, and McIntosh, K: A comparative study of virus isolation, polymerase chain reaction and antigen detection in children of mothers infected with human immunodeficiency virus. J. Ped. 116:372-376, 1990. 97. Browning, MJ, Huang, AS, and Reiss, CS: Cytolytic T lymphocytes from the Balb/c-H-2dm2 mouse recognize the vesicular stomatitis virus glycoprotein and are restricted by class II MHC antigens, J. Immunol. 145:985-994, 1990.

98. Browning, MJ, Reiss, CS, and Huang, AS: The soluble viral glycoprotein of vesicular stomatitis virus efficiently sensitizes target cells for lysis by CD4+ T lymphocytes, J. Virol., 64:3810-3816, 1990. 99. Young, JD, Huang, AS, Ariel, N, Bruins, JB, Ng, D, and Stevens. RL: Coupling efficiencies of amino acids in the solid phase synthesis of peptides, Peptide Research, 3:194-200, 1990. 100. Rose, RM, Krivine, A, Pinkerton, P, Gillis, JM, Huang, AS, and Hammer,SM: Frequent identification of HIV-1 DNA in bronchoalveolar lavage cells obtained from individuals with the acquired immunodeficiency syndrome, Amer. Rev. Respiratory Disease, 143:850-854, 1990. 101. Browning, M, Honeycutt, BS, Huang, AS, and Reiss, CS: Replication defective viruses modulate immune responses, J. Immunol., 142:2685-2691, 1991. 102. Forger, JM, III, Bronson, RT, Huang, AS, and Reiss, CS: Murine infection by vesicular stomatitis virus: Initial characterization of the H-2d system, J. Virol., 65:4950-4958, 1991. 103. Huang, AS, and Coffin, JM: How does variation count? (News and Views in Virology), Nature 359:107-108, 1992. 104. Huang, AS: Science education shouldn't be restricted to narrow boxes, (a commentary) The Scientist, August 31, 1992. 105. Huneycutt, BS, Plakhov, IV, Shusterman, Z, Bartido, SM, Huang, A, Reiss, CS, and Aoki, C: Distribution of vesicular stomatitis virus proteins in the brain of BALB/c mice following intranasal inoculation: an immunohistochemical analysis. Brain Research, 635:81-95, 1994. 106. Chang, TL-Y, Reiss, CS, and Huang, AS: Inhibition of vesicular stomatitis virus RNA synthesis by protein hyperphosphorylation. J. Virol. 68: 4980-4987, 1994. 107. Armstrong, EG, Arky, RA, Block, SD, Federman, Huang, AS, McArdle, PJ, and Moore, GT: Curriculum Design in New Pathways to Medical Education, eds. DC Tosteson, SJ Adelstein, and ST Carver, Harvard University Press, pp. 48-78, 1994. 108. Plakhov, IV, Aoki, C, Reiss, CS, and Huang, AS: Pathogenesis of murine encephalitis limited by defective interfering particles: An immunohistochemical study. J. NeuroVirology, 1:207-218, 1995. 109. Huang, AS: Microbiology in the 1990s and Beyond: Challenges and Rewards, pp. 40-43 in Principles of Microbiology, 2nd Edition, RM Atlas, William C. Brown Publishers, Dubuque, Iowa, 1997. 110. Huang, AS: Once Upon a Heroine, 2nd Edition, A. Cooper-Mullin & JM Coye, Contemporary Books, Chicago, p. 67, 1998. 111. Huang, AS and Baltimore, D: Coming of Age of Animal Virology, ASM News 61 (12): 334-339, 1999. 112. Huang, AS: Marriage Counseling for Boards, Trusteeship (Association of Governing Boards) 7 (6):29- 32, 1999. 113. Huang, AS: In Memoriam: Robert Roderick Wagner, J. Virol., 2001. 114. Huang, AS: Confidence or arrogance? Association for Women in Science Magazine, 32 (4): 6-9, 2003.

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115. Huang, AS: Follow your nose. Nature. 428 (6968 Supplement: China voices), 221-222, 03/11/2003. 116. Huang, AS: Things your professor should have told you: A third of a century's teaching on gaining power for women scientists, pp367-377 in A Hand Up, Women Mentoring Women in Science, Association for Women in Science Publication, Washington, DC, 3rd Edition, 2005. 117. Huang, AS: Momentous Mentoring of Women Scientists, American Society for Cell Biology Newsletter, April, 2010. 118. Huang, AS, and Tan, CYH: Achieving scientific eminence within Asia, Science, 329, 1471-1472, 2010. 119. Huang, AS, Why bother? (editorial), Science, 331, 821, 2011. 120. Huang, AS: Presidential address. Passions. Science,, 334 (6061), 1362-6, 2011.

LETTERS: 1. Fraser, WA, and Huang, AS: Are sulfites really safe? NEJM, 311:542, Aug. 23, 1984. (http://www.nejm.org/doi/full/10.1056/NEJM198408233110824)

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