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A MODEL PATIENT JEROME GROOPMAN Four Students in Their
A MODEL PATIENT JEROME GROOPMAN Four students in their third year at Harvard Medical School recently met a patient named Mr. Martin. The students’ mentors, two physicians, told them that Martin had come to the emergency room complaining of abdominal pain that had grown steadily worse over several days. Martin was lying on a stretcher, moaning. A monitor next to the stretcher indicated that his blood pressure was dangerously low—eighty over fifty-four—and his heart was racing at a hundred and eighteen beats per minute. An X-ray mounted on a light box on the wall showed loops of distended bowel, called an ileus. The intestine can swell like this when it is obstructed or inflamed. “It hurts!” Martin cried as the students reviewed his chart. “They told me you’d give me something for the pain.” “Should we give him something?” one student asked. “I guess so,” another replied. The first student emptied a syringe of morphine into an intravenous line attached to Martin’s arm. Within a few seconds, Martin stopped moaning. Then the monitor started to beep rapidly. Martin had stopped breathing. The syringe had contained twenty milligrams of morphine, a potentially lethal dose for someone in his condition. The students began to perform CPR. One passed an endotracheal tube through Martin’s vocal cords into his airway. Another began to pump oxygen into the tube. Dr. Nancy Oriol, the dean of students at Harvard Medical School, showed me a videotape of the students’ encounter with Martin. “The students didn’t figure it out,” she said. -
Kathy Giusti and the Multiple Myeloma Research Foundation
9-814-026 JUNE 25, 2014 RICHARD G. HAMERMESH JOSHUA D. MARGOLIS MATTHEW G. PREBLE Kathy Giusti and the Multiple Myeloma Research Foundation This is the model for cancer. It is the model for medicine; of what we have to do.1 — Eric Lander, founding director of the Broad Institute Kathy Giusti (HBS ’85) was driving home one evening in January 1996 when she got the call from her doctor.2 He asked if Giusti and her husband Paul (HBS ’85) could come to his office.3 Sensing bad news, Giusti wanted to know what was wrong.4 Her doctor relented and told Giusti that she had multiple myeloma (MM), a rare and fatal cancer.5 Early the next morning, Giusti went to a bookstore near her Chicago, Illinois home and headed for the medical section.6 “We were going through these books, and I started thinking ‘Oh my God, what just happened to my life,’” she recalled. After her appointment, Giusti’s worst fears were confirmed. She could expect to live for just a few more years—three or four at the most. Up to that moment everything seemed to be going as planned.7 Since graduating from Harvard Business School (HBS) just over a decade earlier, Giusti had had one career success after another. At the time of her diagnosis, she was the executive in charge of global operations for G.D. Searle & Co.’s (Searle) arthritis drugs division.8 The Giustis had recently had their first child and just started trying to have a second.9 Now, all was in flux. -
In Their Own Words
DEPARTMENT OF MEDICINE ANNUAL REPORT 2017 Department of Medicine Beth Israel Deaconess Medical Center 330 Brookline Avenue, Boston, MA 02215 617-667-7000 bidmc.org/medicine IN THEIR OWN WORDS Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School and consistently ranks as a national leader among independent hospitals in National Institutes of Health funding. BIDMC is in the community with Beth Israel Deaconess Hospital-Milton, Beth Israel Deaconess Hospital-Needham, Beth Israel Deaconess Hospital-Plymouth, Anna Jaques Hospital, Cambridge Health Alliance, Lawrence General Hospital, Signature Healthcare, Beth Israel Deaconess HealthCare, Community Care Alliance and Atrius Health. BIDMC is also clinically affiliated with the Joslin Diabetes Center and Hebrew SeniorLife and is a research partner of Dana-Farber/Harvard Cancer Center and The Jackson Laboratory. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.org. The Department of Medicine wishes to thank the many individuals who contributed to this report, including department and division leaders. We also thank Gigi Korzenowski and Jerry Clark of Korzenowski Design, and Jennie Greene, Meera Kanabar, and Jacqueline St. Onge of the Department of Medicine. The photography in this report was done by BIDMC’s Jim Dwyer and Danielle Duffey, who also helped with photo research. Jane Hayward, of BIDMC Media Services, provided expert copy editing and design consultation. We also thank several members of the Development and Communications Departments for their input. Last but not least, we wish to thank all of the individuals featured in these pages for contributing their time and perspectives to this year’s annual report. -
Inspirations from the Field the Proverbial
The Newsletter of The Arnold P. Gold Foundation A Public Foundation Dedicated to Fostering Humanism in Medicine Thanksgiving 1999 The Proverbial Inspirations from the field Last Straw! It was a proverbial “last straw” that brought us to Dr. Arnold Gold’s office, “TheWhite Coat–Just in 1995. A few days before our son an item of clothing!! Anthony was to become a first grader, he rushed towards me and the force of Yet we endow it with great his impact knocked me against a wall in symbolism and power. our house,driving my hand into the skin of my face,narrowly missing my eye. When I told my mother about this speech, she told me a story that she had This was only the latest in a number of never shared with me before. My physical “accidents” in which he hurt me, father was a patient in the hospital and for which he would later apologize. where I was a resident. She remembers Anthony had been discharged from two seeing me walking down the hall Members of the Mercer University School of Medicine, child-care centers by age four, not for towards my father’s room. I was dressed Class of 2003, recite the Oath of Geneva during the School’s aggression but for not listening to the August 8, 1999 White Coat Ceremony in Macon, Georgia. in my white coat with a group of distin- teacher and/or being uncooperative. His guished white-coat-clad attending qualities I look for in my physicians are behavior at home was even worse and physicians. -
The CNCF Handbook for Parents of Children with Neuroblastoma
The CNCF Handbook for Parents of Children with Neuroblastoma The CNCF Handbook for Parents of Children with Neuroblastoma Acknowledgements Disclaimer Navigating Neuroblastoma and This Handbook (Read This First!) i Chapter 1 Confronting the Diagnosis 101 What is NB: Description, Diagnosis, and Staging 1:010 102 What is NB: Tumor Pathology and Genetics 1:020 103 What is NB: Risk Assignment 1:030 104 Questions for Your Doctors 1:040 105 U.S. Neuroblastoma Specialists 1:050 106 What is a Clinical Trial? 1:060 107 The World of Hospitals 1:070 108 Patients' Rights & Responsibilities 109 Reaching Out and Accepting Help 1:090 Chapter 2 Understanding the Basics of Frontline Treatments 201 Overview of Low- and Intermediate-Risk Treatment 202 Overview of High-Risk Treatment 2:020 Chapter 3 Coping with Treatment: Side Effects, Comfort, and Safety 301 What is Palliative Care? 302 Getting Through Chemotherapy 3:020 303 Surviving Neutropenia 3:030 304 Special Issues with Stem Cell Transplant(s) 3:040 305 Surgery 306 Central Venous Lines: Broviacs, Hickmans, & Ports 307 Radiation: From Tattoos to Side Effects 308 Coping with ch14.18 Antibodies 309 Coping with 3F8 Antibodies 3:090 310 Coping with 8H9 Intrathecal Antibodies 3:100 311 Coping with Accutane 3:110 312 Coping with MIBG Treatment 3:120 313 Advocating for Your Child 3:130 314 Special Issues for Teenagers and Adults © 2008 Children’s Neuroblastoma Cancer Foundation www.nbhope.org revised 6/29/2009 Table of Contents Chapter 4 Getting Through Tests & Scans 400 Introduction to Getting through Tests -
An Interview with Leonard Zon
© 2014. Published by The Company of Biologists Ltd | Disease Models & Mechanisms (2014) 7, 735-738 doi:10.1242/dmm.016642 A MODEL FOR LIFE From fish tank to bedside in cancer therapy: an interview with Leonard Zon Leonard Zon, who is based at Harvard Medical School, is internationally recognized for his pioneering work in hematology and stem cell biology. His lab uses zebrafish as a model to understand blood cell development and, in recent years, has made inspiring breakthroughs in the treatment of blood diseases and cancer, helping to establish zebrafish as a powerful model for translational research. In this interview, Leonard speaks to Disease Models & Mechanisms Editor-in-Chief, Ross Cagan, about the evolution of his career from developmental biologist to physician-scientist and the stories behind some of his major research accomplishments. He also discusses challenges and opportunities in zebrafish research and provides advice on translating basic research findings to the clinic. Leonard (Len) I. Zon was born in Hartford, CT, USA. He received his undergraduate degree in Chemistry and Natural Sciences from Muhlenberg College in Allentown, PA and, in 1983, obtained an M.D. degree from Jefferson Medical College in neighboring city Philadelphia. While undertaking clinical training at Deaconess Let’s start with your background. Why did you end up Medical Center, he was appointed a fellow in medical oncology at becoming a physician and also a scientist? Dana-Farber Cancer Institute. As a post-doctoral research associate The evolution of my career started while I was in college. I was in Stuart Orkin’s lab, Len sought to understand how specific blood doing research just to try it out but I didn’t really think that it was lineages are programmed at the molecular level. -
Sample NIH Proposal 6
Sample Grant Application Introduction On the following pages you will find one of the Sample R01 Applications and Summary Statements indexed here: http://www.niaid.nih.gov/ncn/grants/app/default.htm Visit the Web site for the most recent information. We may add more in the future. We are truly indebted to the grantees who've allowed us to post their outstanding applications to help the next generation of investigators write applications. Copyright Please note that the application text is copyrighted. It may be used only for nonprofit educational purposes provided the document remains unchanged and the PI, the grantee organization, and NIAID are credited. Contact [email protected] with any questions. OMB Number: 4040-0001 Expiration Date: 06/30/2011 APPLICATION FOR FEDERAL ASSISTANCE 3. DATE RECEIVED BY STATE State Application Identifier SF 424 (R&R) 1. * TYPE OF SUBMISSION 4. a. Federal Identifier Pre-application Application Changed/Corrected Application b. Agency Routing Identifier 2. DATE SUBMITTED Applicant Identifier 5. APPLICANT INFORMATION * Organizational DUNS: * Legal Name: !"#$ Department:%&' Division: .' * Street1: ( )*+,- Street2: )/&%0'1& * City: !"#$ County / Parish: !"#$ * State: !#;!"#$ Province: * Country: )1;!. <) 1 <) * ZIP / Postal Code: 2 Person to be contacted on matters involving this application Prefix: * First Name:3 Middle Name: * Last Name: 1 Suffix: * Phone Number:4 5 2- Fax Number: 4 5- 2 Email: 627'8'9& 6. * EMPLOYER IDENTIFICATION (EIN) or (TIN): ,,,,,,, 7. * TYPE OF APPLICANT: 7;%.:<&' Other (Specify): Small Business Organization Type Women Owned Socially and Economically Disadvantaged 8. * TYPE OF APPLICATION: If Revision, mark appropriate box(es). New Resubmission A. Increase Award B. Decrease Award C. -
William Astbury and the Biological Significance of Nucleic Acids, 1938Â
Studies in History and Philosophy of Biological and Biomedical Sciences 42 (2011) 119–128 Contents lists available at ScienceDirect Studies in History and Philosophy of Biological and Biomedical Sciences journal homepage: www.elsevier.com/locate/shpsc William Astbury and the biological significance of nucleic acids, 1938–1951 Kersten Hall Centre for History and Philosophy of Science, University of Leeds, Leeds LS2 9JT, UK article info abstract Keywords: Famously, James Watson credited the discovery of the double-helical structure of DNA in 1953 to an Astbury X-ray diffraction photograph taken by Rosalind Franklin. Historians of molecular biology have long puz- X-ray crystallography zled over a remarkably similar photograph taken two years earlier by the physicist and pioneer of protein Molecular biology structure William T. Astbury. They have suggested that Astbury’s failure to capitalize on the photograph DNA to solve DNA’s structure was due either to his being too much of a physicist, with too little interest in or knowledge of biology, or to his being misled by an erroneous theoretical model of the gene. Drawing on previously unpublished archival sources, this paper offers a new analysis of Astbury’s relationship to the problem of DNA’s structure, emphasizing a previously overlooked element in Astbury’s thinking: his con- cept of biological specificity. Ó 2010 Elsevier Ltd. All rights reserved. When citing this paper, please use the full journal title Studies in History and Philosophy of Biological and Biomedical Sciences 0. Introduction the textile physicist turned molecular biologist William T. Astbury, by that time an internationally renowned figure in X-ray crystallo- ‘The instant I saw the picture my mouth fell open and my pulse graphic studies of biological materials. -
Consumerism in Health Care: Challenges and Opportunities Richard Zeckhauser, Phd, and Benjamin Sommers, MD, Phd
Virtual Mentor American Medical Association Journal of Ethics November 2013, Volume 15, Number 11: 988-992. OP-ED Consumerism in Health Care: Challenges and Opportunities Richard Zeckhauser, PhD, and Benjamin Sommers, MD, PhD The era of consumerism in health care has arrived. Direct-to-consumer advertising of pharmaceuticals, health newsletters from leading hospitals and medical schools, and, most importantly, the near-ubiquity of the Internet have made it easy for consumers to obtain information about their medical conditions and possible treatments. This presents health care providers and patients with both challenges and opportunities. Challenges of Consumerism in Patient Care Some studies suggest that patients’ consumerism can negatively affect the quality of patient-doctor communications [1, 2]. Physicians are constrained by schedules that limit the typical office visit to 17 minutes [3]. In this context, spending a considerable portion of appointment time trying to correct misperceptions held by consumerist patients who may hold strong opinions with little medical or scientific background is inefficient and impractical. In addition, consumerism among patients may engender negative feelings among doctors. Physicians may feel that consumerism erodes the respect accorded to their profession [4], and many physicians have mixed feelings about discussing web-based medical information during the clinical encounter [5]. Difficulties can arise when the patient’s preconceptions clash with the doctor’s assessment. Perhaps less information gets effectively exchanged. Even when more information is in fact exchanged, the patient may discount what he or she hears from the doctor. Consider a patient who arrives at the doctor’s office, having already settled in his or her own mind on a diagnosis and preferred treatment. -
M.Sc Ist Yr MICROBIOLOGY a Bottle of Wine Contains More Philosophy Than All the Books in the World
M.Sc Ist yr MICROBIOLOGY A bottle of wine contains more philosophy than all the books in the world. -Louis Pasteur JANUARY 2022 M T W T F S S Ferdinand Cohn (Founder of 31 1 2 Bacteriology and Microbiology) Global Family Day 3 4 5 6 7 8 9 Richard Rebecca Har Michael Craighill Gobind Krause Lancefield Khorana Rebecca Craighill Lancefield (well known for serological classification of β- hemolytic streptococcal bacteria) 10 11 12 13 14 15 16 National Indian Youth Day Army Day 17 18 19 20 21 22 23 Bacillus cereus Bacillus cereus is a facultatively anaerobic, toxin producing, gram- positive bacteria that canm be found in siol vegetation anf even food. This may cause two types of intestinal illness, one diarrheal, and 24 25 26 27 28 29 30 one causing nausea and vomiting.It Ferdinand National Heinrich World can quickly multiply at room Kohn Tourism Anton de Leprosy temperature. B.cereus has also been National Girl Day Bary Day Child Day Republic implicated in infections of the eye, respiratory tracts , and in wounds. International Day B.cereus and other members of Day of Education bacillus are not easily killed by alcohol,they have been known to World Leprosy Day – 30th JAUNARY: World Leprosy colonize distilled liquors and Day is observed internationally every year on the last Sunday of alcohol soaked swabs and pads in January to increase the public awareness of leprosy or Hansen's numbers sufficient to cause Disease. This date was chosen by French humanitarian Raoul infection. Follereau as a tribute to the life of Mahatma Gandhi who had compassion for people afflicted with leprosy. -
Feeble-Minded”, 1890-1931
INSTITUTIONALIZING EUGENICS: CUSTODY, CLASS, GENDER AND EDUCATION IN NOVA SCOTIA’S RESPONSE TO THE “FEEBLE-MINDED”, 1890-1931 A Thesis Submitted to the College Graduate Studies and Research In Partial Fulfillment of the Requirements For the Degree of Doctor of Philosophy In the Department of History University of Saskatchewan By Leslie Elaine Baker © Leslie E. Baker, February 2015. All Rights Reserved. Permission to use In presenting this dissertation in partial fulfillment of the requirements for a Doctoral degree from the University of Saskatchewan, I agree that the Libraries of this University may make it freely available for inspection. I further agree that permission for copying of this dissertation in any manner, in whole or in part, for scholarly purposes may be granted by the professor or professors who supervised my dissertation work or, in their absence, by the Head of the Department or the Dean of the College in which my dissertation work was done. It is understood that any copying or publication or use of this dissertation or parts thereof for financial gain shall not be allowed without my written permission. It is also understood that due recognition shall be given to me and to the University of Saskatchewan in any scholarly use which may be made of any material in my dissertation. Requests for permission to copy or to make other use of material in this thesis whole or in part should be addressed to: Head of the Department of History Room 522, Arts Building 9 Campus Drive University of Saskatchewan Saskatoon, Saskatchewan S7N 5A5 Canada i Abstract Between 1890 and 1927 hundreds of Nova Scotian children and adults were identified as either feeble-minded or mentally deficient through investigations conducted by physicians and philanthropists in the province. -
Special Article a History of Pediatric Specialties
0031-3998/03/5501-0163 PEDIATRIC RESEARCH Vol. 55, No. 1, 2004 Copyright © 2003 International Pediatric Research Foundation, Inc. Printed in U.S.A. SPECIAL ARTICLE A HISTORY OF PEDIATRIC SPECIALTIES This is the eighth article in our series on the history of pediatric specialties. Dr. Shulman describes the history of infectious diseases over the centuries. Many of these major killers of children were conquered by research that led to understanding the causes of these diseases and eventually to establishing means of prevention and treatment. Dr. Shulman also describes the organizations and publications that have furthered the development of treatment, research and education in this specialty. The future of this field includes the challenges of understanding and treating infectious diseases in immunocompromised children and in developing countries where infectious disease is still a major killer. The History of Pediatric Infectious Diseases STANFORD T. SHULMAN Northwestern University, The Feinberg School of Medicine, Division of Infectious Diseases, The Children’s Memorial Hospital, Chicago, IL 60614 U.S.A. ABSTRACT The history of Pediatric Infectious Diseases closely parallels (1933) all contributed to the evolution of the discipline of the history of Pediatrics at least until the last century, because Pediatric Infectious Disease, and numerous leaders of these historically infections comprised the major causes of childhood organizations had significant infectious diseases interests. The morbidity and mortality, as they still do in the developing