International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

About the Event International Space Medicine Summit 2010 The International Space Medicine Summit (ISMS) 2010 brings together leading physicians and space biomedical scientists from space-faring nations for high-level discussions on research needed to prevent and/or mitigate the medical and biomedical challenges associated with long-duration space flight.

Building on the recommendations of the first three summits, the goal of ISMS 2010 is to stimulate and facilitate multinational collaborations on how best to maximize the utilization of the International Space Station (ISS) for research to ensure the well-being of astronauts and cosmonauts on future expeditions.

In accordance with the unanimous consensus reached by the multinational participants in last year’s summit, ISMS 2010 will work to identify and focus on high-priority research projects, both space-based and ground-based, that require international collaboration in order to succeed. ISMS 2010 is committed to:

• Fostering increased communication and cooperation; • Focusing on lessons learned from long-duration human space flight and analog environments such as Devon Island, the Antarctic, NASA Extreme Environment Mission Operations (NEEMO), and the multinational, 105-day ground-based simulation study; and • Research efforts to enhance life on Earth by applying the resultant advances in human knowledge and technology acquired through living and working in space.

Organizing Partners James A. Baker III Institute for Public Policy, Rice University The mission of the Baker Institute is to help bridge the gap between the theory and practice of public policy by drawing together experts from academia, government, media, business and nongovernmental organizations. By involving policymakers and scholars, as well as students (tomorrow’s policymakers and scholars), the institute seeks to improve the debate on selected public policy issues and to make a difference in the formulation, implementation and evaluation of public policy, both domestic and international. The Baker Institute is an integral part of Rice University, one of the nation’s most distinguished institutions of higher education. The efforts of Baker Institute fellows and affiliated Rice faculty focus on several ongoing research projects, details of which can be found on the institute’s website, http://bakerinstitute.org.

Baylor College of Medicine Baylor College of Medicine is committed to being a national leader in advancing human health through the integration of patient care, research, education and community service. The college pursues this mission by promoting patient care of the highest standard, advancing basic and clinical biomedical research, sustaining educational excellence, and fostering public awareness of health and the prevention of disease. Since its founding in 1900, Baylor has grown into an internationally respected medical and research institution. Baylor offers patient care services through several of its Texas Medical Center affiliate hospitals and clinics, with more than 152,000 inpatient visits and 2.2 million outpatient visits annually. The college has more than 70 research and patient-care centers and units. More information can be found on the school’s website, http://www.bcm.edu. International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Participating Organizations Association of American Medical Colleges (AAMC) China Astronaut Research and Training Center (ACC) Bauman Moscow State Technical University (Bauman MSTU) Baylor College of Medicine (BCM) Boise State University Canadian Space Agency (CSA) German Aerospace Center (DLR) European Space Agency (ESA) Excalibur Almaz Gagarin Cosmonaut Research and Training Center (GCTC) Henry Ford Health System (HFHS) Institute for Biomedical Problems (IBMP) James A. Baker III Institute for Public Policy, Rice University Japan Aerospace Exploration Agency (JAXA) Massachusetts Institute of Technology (MIT) The Museum of Flight National Aeronautics and Space Administration (NASA) National Institutes of Health (NIH) National Space Biomedical Research Institute (NSBRI) Russian Federal Space Agency (ROSCOSMOS) Tietronix/Safetronix University of Rome

Conference Agenda Thursday, May 20

1800 Opening Reception

Friday, May 21

0800 Continental Breakfast

Welcome, Introductions and Opening Remarks 0830 The Honorable Edward P. Djerejian Founding Director, James A. Baker III Institute for Public Policy, Rice University George W.S. Abbey Baker Botts Senior Fellow in Space Policy, James A. Baker III Institute for Public Policy, Rice University Bobby R. Alford Chancellor, Baylor College of Medicine, and Chairman of the Board and CEO, National Space Biomedical Research Institute International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

The International Space Station (ISS) 2010–2020 0900 Introduction: George Abbey, Baker Institute Reflections on Accomplishments Thus Far and Future Plans Shanguang Chen, ACC Jean-Marc Comtois, CSA Volker Damann, ESA Michael Foale, NASA William Gerstenmaier, NASA Sergei Krikalev, GCTC Chiaki Mukai, JAXA Igor Ushakov, IBMP Topics • Research resources and capabilities (redundancy) • Utilization for research • Sharing facilities • Research collaboration opportunities • Future logistics and support • Crew size and rotations • Space medicine practices • Funding for operations • Limitations • Expectations Discussion and Summation

1015 Break

Panel I — Highest Priorities for Countermeasures Research Moderator: Dave Williams, NSBRI 1030 Introduction: Bobby Alford, BCM/NSBRI Panelists Jeff Davis, NASA Inessa Kozlovskaya, IBMP Sergei Krikalev, GCTC Bob Satcher, NASA Kaz Shimada, JAXA Michel Tognini, ESA Igor Ushakov, IBMP Ming Yuan, ACC Topics • Common science platform • Exercise platform and standardized protocol • International cooperation and collaboration in countermeasures protocols • Radiation — assessment, protection and reduction • Human behavior, health and performance (HRP) • Stress detection • Expanded and standardized medical evaluation protocol • Maintenance of bone integrity • Standardized rehab protocol • Evidence book — a living document Discussion and Summation International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Luncheon 1200 Introduction: Bobby Alford, BCM/NSBRI Cooperation and Collaboration in Research Huda Zoghbi Professor of Pediatrics, Neurology and Neurosciences, Baylor College of Medicine, and Investigator, Howard Hughes Medical Institute Discussion and Questions

1300 NEEMO 14 Live Video: Comments by Chris Hadfield, Mission 14 Leader, and Dave Williams, NSBRI

Panel II — International Interdisciplinary Integrated Collaborative Research in Space Moderator: Neal Lane, Baker Institute 1330 Introduction: Bobby Alford, BCM/NSBRI Mars 500-Day Simulation Video: Comments by Igor Ushakov, IBMP Panelists Shanguang Chen, ACC Jon Clark, NSBRI Volker Damann, ESA Rupert Gerzer, DLR Dennis Grounds, NASA Vadim Gushchin, IBMP Inessa Kozlovskaya, IBMP Julie Robinson, NASA Vladimir Sychev, IBMP Topics • Balanced crew composition • Standardized protocols and test batteries • Shared use of common resources • Composition of joint working group for oversight • Systematic and integrative projects • Budget resources and allocation method • Integration of users in scientific community • Transitional gravity • Assurance of access to data • 105-Day simulation study • Mars 500-Day simulation study • NEEMO and other analog utilization Discussion and Summation

1530 Introduction: George Abbey, Baker Institute Creating the Model Collaborative Research Center Eugene Levy Provost, Rice University Jeff Sutton President and Director, National Space Biomedical Research Institute

1600 Break International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Group Tour: Rice BioScience Research Collaborative 1620 Departure from Baker Institute Introduction: Bobby Alford, BCM/NSBRI 1745 Return to Baker Institute

1800 NASA’s Human Health and Performance Center Jeff Davis Space Life Sciences Director, NASA

Dinner and Keynote Address 1830 Introduction: George Abbey, Baker Institute Perspectives for Space Medicine and Biology Research in Russia Igor Ushakov General Director, Institute for Biomedical Problems

Saturday, May 22

0800 Continental Breakfast

Panel III — Moving Forward with a Collaborative Research Center in Space: The ISS Moderator: William Gerstenmaier, NASA 0830 Introduction: George Abbey, Baker Institute Panelists Shanguang Chen, ACC Jean-Marc Comtois, CSA Jeff Davis, NASA David Dinges, NSBRI Vladimir Katuntsev, IBMP Ann Kennedy, NSBRI Inessa Kozlovskaya, IBMP Chiaki Mukai, JAXA Livio Narici, University of Rome Jeff Sutton, NSBRI Michel Tognini, ESA Topics • Collaborative human system risk management • Types of agreements that must be sought • U.S., Russian, Japanese, ESA, Chinese and Canadian concepts for collaboration • Hurdles to overcome Discussion and Summation

1015 Break International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Panel IV — Bridging the Sciences in Collaborative Research and Education Moderator: Neal Lane, Baker Institute 1045 Introduction: Bobby Alford, BCM/NSBRI Panelists Leon Alkalai, NASA Ludmila Buravkova, IBMP Bonnie Dunbar, The Museum of Flight Dennis Grounds, NASA David Longnecker, AAMC Vera Mayorova, Bauman MSTU Joan McGowan , NIH Barbara Morgan, Boise State University Igor Savelev, NSBRI Bill Thomson, BCM/NSBRI Sam Ting, MIT Topics • Alpha Magnetic Spectrometer • Climate research • Environment assessment • Education focus — students, teachers • Disciplines (engineering, life sciences, informatics, etc.) • Robotic assisted human space flight Discussion and Summation

Luncheon — International Crew Panel 1215 Introduction: George Abbey, Baker Institute Reflections Leroy Chiao, NSBRI Jean-Loup Chretien, Tietronix/Safetronix Mike Foale, NASA Sergei Krikalev, GCTC Michael Lopez-Alegria, NASA Haisheng Nie, ACC Salizhan Sharipov, GCTC Robert Thirsk, CSA Vladimir Titov, Excalibur Almaz Michel Tognini, ESA Koichi Wakata, JAXA Topics • Six-person vs. three-person crew • Crew composition guidelines • Crew schedules • Crew rotation process • Standardized crew training • Equitable resources • Conflict resolution • Access to data • Post-mission rehab Discussion and Summation

International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Discussion Groups Team Member Assignments to be provided 1400 Group A Cooperative International Research Initiatives for ISS and Space Exploration Beyond Earth Orbit Team Leader: Leroy Chiao, NSBRI Topics • Risk management (human) • Evidence book • Scientific discoveries and results from the ISS • Benefits of the ISS National Laboratory: platform for research, commercial venues, international visitors • Research opportunities coordination: Columbus, Destiny, Kibo, Zvezda, Tranquility • Translational research considerations for space exploration • Science that can only be conducted in space • Medical devices required

Group B International Integrated Analog/Ground-Based and Space Collaborative Research Projects Team Leader: Christian Otto, CSA Topics • 105-day simulation study preliminary results • Mars 500-day simulation study • Antarctic, Devon Island, Desert RATS and NEEMO — optimal utilization of other international analogs • Systems support • Research technology support • Medical support for space exploration • Artificial gravity 1/6 G, 1/3 G, 1G • NIH/NASA Agreement: cooperation in space-related health research • EVA requirements, suits and rovers • Bioreactors • Export policy • Radiation protection • Technology transfer

Group C Education Needs and Opportunities for Bridging the Sciences in Space Team Leaders: Bill Thomson, BCM, and Vera Mayorova, Bauman MSTU Topics • Graduate student research • Postdoctoral fellowships • Integration of physics, mathematics, chemistry, biology, engineering and informatics for space life science research • Funding possibilities • STEM (science, technology, engineering, mathematics) education • Vaccine research • Career opportunities and future needs of the space program • Pathways for success • Exchange program for space life scientists, engineers, educators

1700 Recess International Space Medicine Summit 2010 May 20–23, 2010 • James A. Baker III Institute for Public Policy • Rice University

Reception and Dinner 1800 Introduction: George Abbey, Baker Institute Charles Bolden NASA Administrator Music by Avec Strings

Sunday, May 23

0830 Continental Breakfast

Discussion Group Reports 0900 Group A Cooperative International Research Initiatives for ISS and Space Exploration Beyond Earth Orbit Team Leader: Leroy Chiao, NSBRI

Group B International Integrated Analog/Ground-Based and Space Collaborative Research Projects Team Leader: Christian Otto, CSA

Group C Education Needs and Opportunities for Bridging the Sciences in Space Team Leaders: Bill Thomson, BCM, and Vera Mayorova, Bauman MSTU

1200 Closing