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CENTERS & TECHNOLOGIES Along with its faculty labs, the LSI is also home to specialized core laboratories and cutting-edge resources to advance basic biology and drug discovery projects. Most are open to U-M investigators and external users. Center for Chemical Genomics • High-throughput screening for basic biology & drug discovery • 160,000 chemical compounds & 40,000 natural product extracts • High-throughput assay development & optimization • Target validation & pathway analysis Center for Structural Biology • High-throughput protein laboratory for protein engineering • Protein purification facility (small & large protein production) • Macromolecular crystallization & crystallography labs DISCOVERY • Access to synchrotron at Argonne National Laboratory UNBOUNDED Cryo-Electron Microscopy • Advanced instrumentation platform for various levels of About the Life Sciences Institute molecular characterization Our mission is to advance the understanding of • High-resolution capabilities through an FEI Arctica & the fundamental processes of life, and to pioneer a Titan Krios equipped with Gatan K2 Summit direct new ideas to improve human health. electron detectors Our faculty members have broad and diverse • Funding from the U-M Biosciences Initiative to add expertise — ranging from cell biology to cryo-electron tomography and other advances medicine, from chemistry to structural biology. And the LSI provides them with a research Mass Spectrometry home purposefully designed to foster creative • Open and assisted services for the analysis of proteins and risk taking, interdisciplinary collaboration small molecules, as well as training on use of the instruments and professional growth. • Agilent 6545 Q-t of LS/MS system Natural Products Discovery Core • Unique 40,000-sample library of natural product extracts from diverse marine and terrestrial actinomycetes, fungi and cyanobacteria • Rapid genomic and metabolomic profiling to identify high-value molecules as probes and drug leads • Technology and expertise to develop candidates identified through high-throughput screening into patentable small molecules • Funding from the U-M Biosciences Initiative to add state-of-the art mass spectrometry and NMR resources for structure elucidation lsi.umich.edu/science/centers-technologies.

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CV Than, NA Rosenberg
Noah A. Rosenberg Department of Biology Stanford University Stanford, CA 94305-5020 USA (650) 721-2599 (phone) (650) 724-5114 (fax) [email protected] http://rosenberglab.stanford.edu/ August 9, 2017 Academic appointments 2014- Stanford Professor of Population Genetics and Society, Stanford University School of Humanities and Sciences 2014- Professor, Stanford University Department of Biology 2011-2014 Associate Professor, Stanford University Department of Biology 2009-2011 Associate Professor, University of Michigan Depts. of Human Genetics, Ecology & Evolutionary Biology, and Biostatistics Research Associate Professor, University of Michigan Life Sciences Institute and Center for Computational Medicine & Bioinformatics 2005-2009 Assistant Professor, University of Michigan Depts. of Human Genetics, Ecology & Evolutionary Biology (2006-2009), and Biostatistics Research Assistant Professor, University of Michigan Life Sciences Institute and Center for Computational Medicine & Bioinformatics Education 2001-2005 Postdoc, University of Southern California, Molecular and Computational Biology 1998-2001 PhD, Stanford University, Biological Sciences 1997-1999 MS, Stanford University, Mathematics 1993-1997 BA, Rice University, Mathematics and Russian Studies, summa cum laude Awards Fellowships 2007 Faculty Research Grant, University of Michigan Rackham Graduate School 2006 Faculty Fellowship Enhancement Award, University of Michigan Rackham Graduate School 2006-2010 Alfred P. Sloan Research Fellowship in Computational and Evolutionary Molecular
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Angela N. Koehler
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Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells Alexander Sio1*, Manreet K
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Angela N. Koehler
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An Opportunity to Build “One Missouri”
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Executive Summary
THE LIFE SCIENCES INSTITUTE DIABETES : BIOMARKERS TO CURES Diabetes expertise at the UBC Life Sciences Institute 7% of Canadians live with diabetes. Their As of 2014, 387 million people worldwide suffer with diabetes at a stunning cost of over $450 billion annual direct medical costs are expected to for medical attention. The complexity of this disease – reach $16.9 billion by 2020. due to its multi-genetic nature and the innate genetic differences of individuals within this population – has Only ~50% of conventional therapies are perplexed scientists for decades. With advances in effective in the person for whom they are our understanding of the mechanisms underlying this prescribed and many cause adverse side disease, we are poised to better understand the complex effects. Personalized diagnosis is key to nature of diabetes and how to more effectively diagnose, treatment. treat, and one day cure this devastating disease. Researchers in the Life Sciences Institute (LSI), the The Life Sciences Institute Diabetes Research largest institute of its kind in Canada, are positioned to Group is a leading team of experts dedicated take a lead in unraveling medicine’s greatest challenges and providing the data needed by the healthcare to tackling diabetes for better diagnosis and system through an evidence-based approach to achieve treatment. more precise management of health and treatment of disease. The LSI Diabetes Research Group, with its upon drugs. It has been estimated that diabetes reduces unique complement of diabetes research programs, has lifespan on average by 15 years. In fact, deaths due to considerable expertise in the areas of molecular biology, diabetes-related causes approach those of all cancers genetics, biochemistry, cell biology and physiology.
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MINKUI LUO, PH.D. 1 | Page Chemical Biology Program Phone
MINKUI LUO, PH.D. Chemical Biology Program Phone: (646)-888-3066 Memorial Sloan Kettering Cancer Center Fax: (646)-888-3166 1275 York Avenue, Box 248 Email: [email protected] New York, NY 10065 Web: www.mskcc.org/luo PERSONAL Born: Sep. 20th, 1976; Urumqi, Xinjiang, China Citizenship: China (US permanent resident) ACADEMIC APPOINTMENTS 2019-present Member of Chemical Biology, Memorial Sloan Kettering Cancer Center 2019-present Professor of Pharmacology, Weill Medical College of Cornell University 2019-present Professor of Tri-Institute Program of Chemical Biology 2019-present Professor, Gerstner Sloan Kettering Graduate School of Biomedical Sciences 2014-2019 Associate Member of Chemical Biology, Memorial Sloan Kettering Cancer Center 2014-2019 Associate Professor of Pharmacology, Weill Medical College of Cornell University 2014-2019 Associate Professor of Tri-Institute Program of Chemical Biology 2014-2019 Associate Professor, Gerstner Sloan Kettering Graduate School of Biomedical Sciences 2008-2014 Assistant Member of Chemical Biology, Memorial Sloan Kettering Cancer Center 2008-2014 Assistant Professor of Pharmacology, Weill Medical College of Cornell University 2008-2014 Assistant Professor of Tri-Institute Program of Chemical Biology 2008-2014 Assistant Professor, Gerstner Sloan Kettering Graduate School of Biomedical Sciences 2008-2014 Assistant Member of Mol. Pharm. & Chem., Memorial Sloan Kettering Cancer EDUCATION & TRAINING 2005-2008 Postdocoral Fellow in Biochemistry & Chemical Biology, Albert Einstein College of Medicine, with
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BIOGRAPHICAL SKETCH Sean J. Morrison Director of Children's
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Programs at the Institute
PROTEIN ENGINEERING & Biological Design SALTIEL LIFE SCIENCES SYMPOSIUM SEPTEMBER 25, 2019 EIGHTEENTH ANNUAL LSI SYMPOSIUM FORUM HALL, PALMER COMMONS 1OO WASHTENAW AVE, ANN ARBOR #LSIsymposium2019 The Life Sciences Institute is committed to educating the scientific leaders of tomorrow. Help support students in our labs today by making a gift to educational and professional development programs at the institute. Make your gift at: lsi.umich.edu/giving SCHEDULE 8:45 A.M. 11:00 A.M. Welcome How do proteins evolve Roger D. Cone, Ph.D. Dan Tawfik, Ph.D. Vice Provost and Director, U-M Biosciences Initiative; Professor, Department of Biomolecular Sciences, Mary Sue Coleman Director, Life Sciences Institute; Weizmann Institute of Science Professor of Molecular and Integrative Physiology, Medical School; Professor of Molecular, Cellular, and 11:50 A.M. Developmental Biology, College of Literature, Science, Poster session & lunch (Great Lakes Rooms) and the Arts 1:20 P.M. Mark S. Schlissel, M.D., Ph.D. Biosystems design via directed evolution President of the University of Michigan Huimin Zhao, Ph.D. Steven L. Miller Chair, Department of Chemical and 8:55 A.M. Biomolecular Engineering; Professor of Chemistry, Introduction of the Mary Sue and Kenneth Coleman Life Biochemistry, Biophysics and Bioengineering, University Sciences Lecturer of Illinois at Urbana-Champaign Alan R. Saltiel, Ph.D. Professor and Director, Institute for Diabetes and 2:10 P.M. Metabolic Health, University of California San Diego Navigating the landscapes of protein interaction School of Medicine; Director, Life Sciences Institute specificity (2002–2015) Amy E. Keating, Ph.D. Professor of Biology and Biological Engineering, 9:00 A.M.
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Synapse Speaker List
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Programs at the Institute
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