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Angela N. Koehler

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Angela N. Koehler Angela N. Koehler Koch Institute for Integrative Cancer Research at MIT Office: 617-324-7631 Department of Biological Engineering, MIT Email: [email protected] 76-361C Website: http://koehler-lab.mit.edu/ 77 Massachusetts Avenue Cambridge, MA 02139 Education Ph.D. Chemistry, Harvard University 2003 B.A. Biochemistry and Molecular Biology, Reed College 1997 Professional Appointments Associate Professor, Department of Biological Engineering, MIT 2019-present Institute Member, Broad Institute of MIT and Harvard 2019-present Founding Member, MIT Center for Precision Cancer Medicine 2018-present Goldblith Career Development Professor in Applied Biology 2018-2021 Intramural Faculty, Koch Institute for Integrative Cancer Research at MIT 2014-present Assistant Professor, Department of Biological Engineering, MIT 2014-2018 Karl Van Tassel (1925) Career Development Professor 2014-2017 Director, Transcriptional Chemical Biology, Chemical Biology Program, Broad Institute 2010-2013 Project & Center Manager, Broad NCI Cancer Target Discovery and Development (CTD2) Center Institute Fellow, Chemical Biology Program, Broad Institute 2003-2009 Director, Ligand Discovery, NCI Initiative for Chemical Genetics (ICG) at Harvard Research Training Graduate Student, Department of Chemistry and Chemical Biology, Harvard University 1998-2003 Laboratory of Professor Stuart L. Schreiber Committee: Professors Eric. N. Jacobsen, David R. Liu Thesis: Small molecule microarrays: A high-throughput tool for discovering protein-small molecule interactions Researcher, Department of Chemistry, California Institute of Technology 1997-1998 Laboratory of Professor Barbara Imperiali Project: Biochemical reconstitution of the oligosaccharyltransferase (OST) complex Undergraduate Researcher, Department of Chemistry, Reed College 1995-1997 Laboratory of Professor Arthur Glasfeld Co-mentored by Professor Richard G. Brennan at Oregon Health Sciences University Thesis: Biochemical and structural characterization of the tRNA-modifying enzyme QueA from Escherichia coli Teaching Massachusetts Institute of Technology Analysis of Biomolecular and Cellular Systems (20.320) F14, F15 Biological Engineering Design (20.380) S15, S16, F16, F17 Laboratory Fundamentals in Biological Engineering (20.109) S17, S18, S19, F19, S20 Harvard University Biochemical Sciences Research for Undergraduates (BS91r) 2004-present Experimental Research in the Life Sciences (LS100r) F09 Experimental Molecular and Cellular Biology (MCB100) F04, S05, F05, S06 Honors and Awards Junior Bose Award for Teaching Excellence, MIT 2019 NSF CAREER Award 2019 AACR-Bayer Innovation and Discovery Award 2018 Ono Foundation Pharma Breakthrough Award 2017 Novartis Lectureship in Chemistry 2017-2018 Merkin Institute Fellow, Broad Institute, MIT 2014 Genome Technology Young Investigator 2012-2013 Kavli Frontiers of Science Scholar, US National Academy of Sciences 2011 Indo-US Frontiers of Science Exchange Award 2011 Eli Lilly Predoctoral Fellowship in Organic Chemistry, Harvard University 2001-2002 MIT 50K Entrepreneur Team Competition, Finalist 2001 Excellence in Scholarship Award, Reed College 1995-1997 William and Jane Einzig Memorial Scholarship, Reed College 1993-1997 ESCO Undergraduate Scholarship, Reed College 1993-1997 Professional Service ACS Pharmacology & Translational Science Editorial Advisory Board 2019-present Cell Reports Physical Science Editorial Advisory Board 2019-present Co-Director, MIT Biomedical Engineering Minor Program, Department of Biological Engineering 2017-present Steering Committee, Cancer Program, Broad Institute 2017-present Committee on Pre-Health Advising (COPA), MIT Global Education & Career Development Office 2016-present 2018 AACR Annual Meeting Program Committee, Chairperson of the Proteomics and Mass 2017-2018 Spectrometry Section of the Cancer Chemistry Subcommittee Koch Institute/Biology Department Faculty Search Committee 2017-2018, 2019-2020 Chair, 2017 BE Retreat Organizing Committee 2017 MIT Deshpande Center Finalist Review Panel 2017 Chemistry in Cancer Research Steering Committee, American Association for Cancer Research 2016-2018 Faculty Advisor, Biological Engineering Resources for Easing Friction and Stress (REFS) 2016-2018 MIT Biological Engineering, Communications Lab Hiring Committee 2016-2017 Faculty Co-advisor, High-Throughput Screening Facility, Koch’s Swanson Biotechnology Center 2014-present MIT Biological Engineering Graduate Program Committee 2014-present MIT Biological Engineering Faculty Recruitment Committee 2014-2015 Ad Hoc Reviewer, Chemistry of Life Sciences, National Science Foundation 2014 Florida Translational Research Program, Sanford-Burnham, External Advisory Panel 2013-2015 Broad@10 Therapeutics Council, Broad Institute 2013-2014 Broad@10 Leadership and Connectivity Committee, Broad Institute 2013-2014 Standing Member, NIH Drug Discovery and Molecular Pharmacology (DMP) Study Section 2013-2020 MISTI Global Seeds Fund Review Panel, MIT 2013 Lawrence H. Summers Fellowship Selection Committee, Broad Institute 2012 Ad Hoc Member, NIH Drug Discovery and Molecular Pharmacology (DMP) Study Section 2012 Science of Therapeutics (SofT) Organizing Committee, (Chair, 2013-2014), Broad Institute 2011-2014 Dana-Farber Cancer Institute CURE Program for URMs 2011, 2013 Ad Hoc Member, NIH Synthetic and Biological Chemistry B (SBCB) Study Section 2011 Principal Advisor, STEMid, Harvard and MIT 2011-2013 Chemical Biology Program Leadership Committee, Broad Institute 2010-2013 Advisory Panel, NRC Canada, Genomics and Health Initiative, BioChips Project 2008-2011 Broad Institute Summer Research Program in Genomics for URMs 2007-2012 Broad Institute Educational Outreach Program Admissions Panel and Research Mentor 2007-2012 Intel National Science Talent Search Mentor (Megan Blewett, 7th-place out of 1,700) 2006-2007 High-Throughput Screening Review Board, Broad Institute 2005-2012 Chembank Steering Committee, NCI Initiative for Chemical Genetics 2005-2006 Technology Platform Committee, Broad Institute 2004-2006 Industry Relationships Scientific Collaboration, MIT-GSK G.B. Elion Fellowship (Struntz, Koehler) 2018-present Scientific Founder, Scientific Advisory Board Member, Consultant, Kronos Bio, Cambridge, MA. 2017-present Consultant, Proteostasis, Cambridge, MA 2017 Consultant, Novartis, Oncology, Cambridge, MA 2016-2018 Scientific Advisory Board Member, MS2Array, Pittsburgh, PA. 2015-present Scientific Collaboration, Transcend Program, Janssen Pharmaceuticals 2014-2016 Scientific Founder, Consultant, Ligon Discovery, Cambridge, MA 2007-2011 Publications Department of Biological Engineering, Koch Institute for Integrative Cancer Research, MIT 1. Andrew Chen, Angela N. Koehler, Inhibiting transcription factors: lessons learned and emerging targets.” Trends in Molecular Medicine, Submitted, October 2019. 2. Nicholas B. Struntz, Andrew Chen, Anja Deutzmann, Robert M. Wilson, Eric Stefan, Helen L. Evans, Maricela A. Ramirez, Tong Liang, Francisco Caballero, Mattheus H. Wildschut, Dylan V. Neel, Marius S. Pop, Marie McConkey, Sandrine Muller, Brice H. Curtin, Hanna Tseng, Kristen R. Frombach, David B. Freeman, Vincent L. Butty, Stuart S. Levine, Clementine Feau, Sarah Elmiligy, Jiyoung A. Hong, Timothy A. Lewis, Amedeo Vetere, Paul A. Clemons, Scott A. Malstrom, Benjamin L. Ebert, Charles Y. Lin, Dean W. Felsher, Angela N. Koehler, “Stabilization of the Max homodimer with a small molecule attenuates Myc- driven transcription.” Cell Chemical Biology, 26, 711-723, 2019. 3. Becky S. Leifer, Shelby K. Doyle, Helen L. Evans, André Richters, Angela N. Koehler, “An array-based ligand discovery platform for proteins with short half-lives.” Methods in Enzymology, 610, 191-218, 2018. 4. David B. Freeman, André Richters, Marius S. Pop, Nicholas B. Struntz, Angela N. Koehler. “Emerging non- canonical small molecule inhibitors of Androgen Receptor (AR) and its interactome partners for the treatment of castrate-resistant prostate cancer.” Medicinal Chemistry Reviews, Volume 3, Chapter 14, 268-282, 2018. 5. André Richters, Angela N. Koehler, “Epigenetic Modulation using Small Molecules – Targeting histone acetyltransferases in disease, Current Medicinal Chemistry, 24, 4121-4150, 2017. 6. Jeffrey J. Coleman, Tomomi Kimura, Julia Munro, Michael P. Wu, Rakhee R. Busanelli, Angela N. Koehler, Meryl Thomas, Florence F. Wagner, Edward B. Holson, Eleftherios Mylonakis. “The Immunomodulatory activity of caffeic acid phenethyl ester in Caenorhabditis elegans is mediated by the CED-10 (Rac-1)/PAK-1 pathway.” Future Med. Chem., 8, 17, 2016. 7. Yikai Wang, Jean-Yves Wach, Patrick Sheehan, Cheng Zhong, Chenyang Zhan, Richard Harris, Steven C. Almo, Joshua Bishop, Stephen H. Haggarty, Alexander Ramek, Kayla Berry, Conor O’Herin, Angela N. Koehler, Alvin Hung, Damian W. Young. “Application of diversity-oriented synthesis as a strategy for fragment evolution against GSK3beta. ACS Med. Chem. Lett. 7, 852-856, 2016. 8. Zhihong Yang, Angela N. Koehler, Li Wang. “A novel small molecule activator of nuclear receptor SHP inhibits HCC cell migration via suppressing Ccl2.” Mol. Cancer Ther. 15, 2294-2301, 2016. 9. Zarko Boskovic, Melissa M. Kemp, Allyson M. Freedy, Vasanthi S. Viswanathan, Marius S. Pop, Jason H. Fuller, Nicole Martinez, Samuel O. Figueroa Lazu, Jiyoung A. Hong, Timothy A. Lewis, Daniel Calarese, James D. Love, Amedeo Vetere, Steven C. Almo, Stuart L. Schreiber, Angela N. Koehler. “A chemically triggered electrophile shows selective in vitro inhibition among zinc-dependent lysine deacetylases.”
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