CENTERS & TECHNOLOGIES Along with its faculty labs, the LSI is also home to specialized core laboratories and cutting-edge resources to advance basic biology and drug discovery projects. Most are open to U-M investigators and external users. Center for Chemical Genomics • High-throughput screening for basic biology & drug discovery • 160,000 chemical compounds & 40,000 natural product extracts • High-throughput assay development & optimization • Target validation & pathway analysis Center for Structural Biology • High-throughput protein laboratory for protein engineering • Protein purification facility (small & large protein production) • Macromolecular crystallization & crystallography labs DISCOVERY • Access to synchrotron at Argonne National Laboratory UNBOUNDED Cryo-Electron Microscopy • Advanced instrumentation platform for various levels of About the Life Sciences Institute molecular characterization Our mission is to advance the understanding of • High-resolution capabilities through an FEI Arctica & the fundamental processes of life, and to pioneer a Titan Krios equipped with Gatan K2 Summit direct new ideas to improve human health. electron detectors Our faculty members have broad and diverse • Funding from the U-M Biosciences Initiative to add expertise — ranging from cell biology to cryo-electron tomography and other advances medicine, from chemistry to structural biology. And the LSI provides them with a research Mass Spectrometry home purposefully designed to foster creative • Open and assisted services for the analysis of proteins and risk taking, interdisciplinary collaboration small molecules, as well as training on use of the instruments and professional growth. • Agilent 6545 Q-t of LS/MS system Natural Products Discovery Core • Unique 40,000-sample library of natural product extracts from diverse marine and terrestrial actinomycetes, fungi and cyanobacteria • Rapid genomic and metabolomic profiling to identify high-value molecules as probes and drug leads • Technology and expertise to develop candidates identified through high-throughput screening into patentable small molecules • Funding from the U-M Biosciences Initiative to add state-of-the art mass spectrometry and NMR resources for structure elucidation lsi.umich.edu/science/centers-technologies.