The Lymphoma Guide Information for Patients and Caregivers
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IRF4/DUSP22 Gene Rearrangement by FISH
IRF4/DUSP22 Gene Rearrangement by FISH The IRF4/DUSP22 locus is rearranged in a newly recognized subtype of non-Hodgkin lymphoma, large B-cell lymphoma with IRF4 rearrangement. These lymphomas are uncommon, but are clinically distinct from morphologically similar lymphomas, Tests to Consider including diffuse large B-cell lymphoma, high-grade follicular lymphoma, and pediatric- type follicular lymphoma. The IRF4/DUSP22 locus is also rearranged in a subset of ALK- IRF4/DUSP22 (6p25) Gene Rearrangement negative anaplastic large cell lymphomas (ALCL), where this rearrangement is associated by FISH 3001568 with a signicantly better prognosis. Method: Fluorescence in situ Hybridization (FISH) Test is useful in identifying ALK-negative anaplastic large cell lymphomas and large B- Disease Overview cell lymphoma with IRF4 rearrangement The rearrangement is associated with an improved prognosis Incidence See Related Tests Large B-cell lymphoma with IRF4 rearrangement accounts for <1% of all non-Hodgkin B-cell lymphomas overall More common in younger patients, with an incidence of 5-6% under age 18 IRF4/DUSP22 rearrangement is found in 30% of ALK-negative ALCLs Symptoms/Findings Large B-cell lymphoma with IRF4 rearrangement typically presents with limited stage disease in the head and neck, while the presentation of ALK-negative ALCLs is variable. Disease-Oriented Information Patients with large B-cell lymphoma with IRF4 rearrangement typically have a favorable outcome after treatment. Rearrangement of the IRF4/DUSP22 locus in ALK-negative ALCL is associated with a better prognosis than ALK-negative ALCL without this rearrangement. Test Interpretation Analytical Sensitivity The limit of detection (LOD) for the IRF4/DUSP22 probe was established by calculating the upper limit of the abnormal signal pattern in normal cells using the Microsoft Excel BETAINV function. -
Follicular Lymphoma
Follicular Lymphoma What is follicular lymphoma? Let us explain it to you. www.anticancerfund.org www.esmo.org ESMO/ACF Patient Guide Series based on the ESMO Clinical Practice Guidelines FOLLICULAR LYMPHOMA: A GUIDE FOR PATIENTS PATIENT INFORMATION BASED ON ESMO CLINICAL PRACTICE GUIDELINES This guide for patients has been prepared by the Anticancer Fund as a service to patients, to help patients and their relatives better understand the nature of follicular lymphoma and appreciate the best treatment choices available according to the subtype of follicular lymphoma. We recommend that patients ask their doctors about what tests or types of treatments are needed for their type and stage of disease. The medical information described in this document is based on the clinical practice guidelines of the European Society for Medical Oncology (ESMO) for the management of newly diagnosed and relapsed follicular lymphoma. This guide for patients has been produced in collaboration with ESMO and is disseminated with the permission of ESMO. It has been written by a medical doctor and reviewed by two oncologists from ESMO including the lead author of the clinical practice guidelines for professionals, as well as two oncology nurses from the European Oncology Nursing Society (EONS). It has also been reviewed by patient representatives from ESMO’s Cancer Patient Working Group. More information about the Anticancer Fund: www.anticancerfund.org More information about the European Society for Medical Oncology: www.esmo.org For words marked with an asterisk, a definition is provided at the end of the document. Follicular Lymphoma: a guide for patients - Information based on ESMO Clinical Practice Guidelines – v.2014.1 Page 1 This document is provided by the Anticancer Fund with the permission of ESMO. -
Circle) None Fever Night Sweats Wt Loss Laboratory Studies Hgb WBC Plate
LYMPHOMA STAGING DIAGRAM Instructions: boxed items must be completed History B Sx (Circle) none fever night sweats wt loss Laboratory studies Hgb WBC Plate ECOG performance status g/L x109/L x109/L LDH (patient/upper normal) / CERVICAL PRE-AURICULAR HIV antibody pos neg WALDEYER'S RING UPPER CERVICAL MEDIAN OR LOWER CERVICAL HBsAg pos neg POSTERIOR CERVICAL SUPRACLAVICULAR INFRACLAVICULAR MEDIASTINAL HBcoreAb pos neg PARATRACHEAL MEDIASTINAL AXILLARY Hep C Ab pos neg AXILLARY HILAR RETROCRURAL SPE monoclonal protein pos neg type____________ SPLEEN PARA AORTIC PARA AORTIC MESENTERIC For Hodgkin lymphoma only CELIAC COMMON ILIAC SPLENIC (HEPATIC) HILAR EXTERNAL ILIAC PORTAL Albumin g/L INGUINAL MESENTERIC Lymphs x 109/L INGUINAL FEMORAL OTHER EPITROCHLEAR POPLITEAL Treatment Largest tumor diameter (nearest whole cm) Treatment plan Initial biopsy site Date (d/m/y) / / Histologic diagnosis Doctor in Charge 1 _________________________________________ 2 Reason for referral Bone marrow pos neg not done New Recurrent Follow-up Completed by _______________ Date____________ List all other extranodal sites here 1 2 Complete if diagnosis or stage subsequently changed 3 4 Diagnosis/Stage amended to _________________________ 5 Reason__________________________________________ 6 By_______________________ Date______________ Stage (circle) 0 1 2 3 4 A B E This staging diagram can be found on NOTIFY PATIENT INFORMATION IF STAGE OR H:lym_docs\staging\lymphoma.doc DIAGNOSIS IS AMENDED Form #TH-41 Revised 26 March 2007 LYMPHOMA AND CHRONIC LYMPHOCYTIC LEUKEMIA STAGING SYSTEMS BCCA LYMPHOMA, HODGKIN AND CHRONIC LYMPHOCYTIC LEUKEMIA NON-HODGKIN 1982 STAGE FINDINGS STAGE INVOLVEMENT 0 Lymphocyte count > 5.0 x 109 /L 1 Single lymph node region (1) or one Bone marrow contains 40% extralymphatic site (1E). -
The Lymphoma and Multiple Myeloma Center
The Lymphoma and Multiple Myeloma Center What Sets Us Apart We provide multidisciplinary • Experienced, nationally and internationally recognized physicians dedicated exclusively to treating patients with lymphoid treatment for optimal survival or plasma cell malignancies and quality of life for patients • Cellular therapies such as Chimeric Antigen T-Cell (CAR T) therapy for relapsed/refractory disease with all types and stages of • Specialized diagnostic laboratories—flow cytometry, cytogenetics, and molecular diagnostic facilities—focusing on the latest testing lymphoma, chronic lymphocytic that identifies patients with high-risk lymphoid malignancies or plasma cell dyscrasias, which require more aggresive treatment leukemia, multiple myeloma and • Novel targeted therapies or intensified regimens based on the other plasma cell disorders. cancer’s genetic and molecular profile • Transplant & Cellular Therapy program ranked among the top 10% nationally in patient outcomes for allogeneic transplant • Clinical trials that offer tomorrow’s treatments today www.roswellpark.org/partners-in-practice Partners In Practice medical information for physicians by physicians We want to give every patient their very best chance for cure, and that means choosing Roswell Park Pathology—Taking the best and Diagnosis to a New Level “ optimal front-line Lymphoma and myeloma are a diverse and heterogeneous group of treatment.” malignancies. Lymphoid malignancy classification currently includes nearly 60 different variants, each with distinct pathophysiology, clinical behavior, response to treatment and prognosis. Our diagnostic approach in hematopathology includes the comprehensive examination of lymph node, bone marrow, blood and other extranodal and extramedullary tissue samples, and integrates clinical and diagnostic information, using a complex array of diagnostics from the following support laboratories: • Bone marrow laboratory — Francisco J. -
Anaplastic Large Cell Lymphoma (ALCL)
Helpline (freephone) 0808 808 5555 [email protected] www.lymphoma-action.org.uk Anaplastic large cell lymphoma (ALCL) This page is about anaplastic large-cell lymphoma (ALCL), a type of T-cell lymphoma. On this page What is ALCL? Who gets it? Symptoms Treatment Relapsed and refractory ALCL Research and targeted treatments We have separate information about the topics in bold font. Please get in touch if you’d like to request copies or if you would like further information about any aspect of lymphoma. Phone 0808 808 5555 or email [email protected]. What is ALCL? Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma – a non-Hodgkin lymphoma that develops from white blood cells called T cells. Under a microscope, the cancerous cells in ALCL look large, undeveloped and very abnormal (‘anaplastic’). There are four main types of ALCL. They have complicated names based on their features and the types of proteins they make: • ALK-positive ALCL (also known as ALK+ ALCL) is the most common type. In ALK-positive ALCL, the abnormal T cells have a genetic change (mutation) that means they make a protein called ‘anaplastic lymphoma kinase’ (ALK). In other words, they test positive for ALK. ALK-positive ALCL is a fast-growing (high-grade) lymphoma. Page 1 of 6 © Lymphoma Action • ALK-negative ALCL (also known as ALK- ALCL) is a high-grade lymphoma that accounts for around 3 in every 10 cases of ALCL. The abnormal T cells do not make the ALK protein – they test negative for ALK. -
CD20-Negative Diffuse Large B-Cell Lymphomas: Biology and Emerging Therapeutic Options
Expert Review of Hematology ISSN: 1747-4086 (Print) 1747-4094 (Online) Journal homepage: http://www.tandfonline.com/loi/ierr20 CD20-negative diffuse large B-cell lymphomas: biology and emerging therapeutic options Jorge J Castillo, Julio C Chavez, Francisco J Hernandez-Ilizaliturri & Santiago Montes-Moreno To cite this article: Jorge J Castillo, Julio C Chavez, Francisco J Hernandez-Ilizaliturri & Santiago Montes-Moreno (2015) CD20-negative diffuse large B-cell lymphomas: biology and emerging therapeutic options, Expert Review of Hematology, 8:3, 343-354, DOI: 10.1586/17474086.2015.1007862 To link to this article: http://dx.doi.org/10.1586/17474086.2015.1007862 Published online: 01 Feb 2015. Submit your article to this journal Article views: 165 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ierr20 Download by: [North Shore Med Ctr], [Jorge Castillo] Date: 16 March 2016, At: 07:44 Review CD20-negative diffuse large B-cell lymphomas: biology and emerging therapeutic options Expert Rev. Hematol. 8(3), 343–354 (2015) Jorge J Castillo*1, CD20-negative diffuse large B-cell lymphoma (DLBCL) is a rare and heterogeneous group of Julio C Chavez2, lymphoproliferative disorders. Known variants of CD20-negative DLBCL include plasmablastic Francisco J lymphoma, primary effusion lymphoma, large B-cell lymphoma arising in human herpesvirus 8-associated multicentric Castleman disease and anaplastic lymphoma kinase-positive DLBCL. Hernandez-Ilizaliturri3 Given the lack of CD20 expression, atypical cellular morphology and aggressive clinical and Santiago 4 behavior characterized by chemotherapy resistance and inferior survival rates, CD20-negative Montes-Moreno DLBCL represents a challenge from the diagnostic and therapeutic perspectives. -
Lymphoproliferative Disorders
Lymphoproliferative disorders Objectives: • To understand the general features of lymphoproliferative disorders (LPD) • To understand some benign causes of LPD such as infectious mononucleosis • To understand the general classification of malignant LPD Important. • To understand the clinicopathological features of chronic lymphoid leukemia Extra. • To understand the general features of the most common Notes (LPD) (Burkitt lymphoma, Follicular • lymphoma, multiple myeloma and Hodgkin lymphoma). Success is the result of perfection, hard work, learning Powellfrom failure, loyalty, and persistence. Colin References: Editing file 435 teamwork slides 6 girls & boys slides Do you have any suggestions? Please contact us! @haematology436 E-mail: [email protected] or simply use this form Definitions Lymphoma (20min) Lymphoproliferative disorders: Several clinical conditions in which lymphocytes are produced in excessive quantities (Lymphocytosis) increase in lymphocytes that are not normal Lymphoma: Malignant lymphoid mass involving the lymphoid tissues. (± other tissues e.g: skin, GIT, CNS ..) The main deference between Lymphoma & Leukemia is that the Lymphoma proliferate primarily in Lymphoid Tissue and cause Mass , While Leukemia proliferate mainly in BM& Peripheral blood Lymphoid leukemia: Malignant proliferation of lymphoid cells in Bone marrow and peripheral blood. (± other tissues e.g: lymph nodes, spleen, skin, GIT, CNS ..) BCL is an anti-apoptotic (prevent apoptosis) Lymphocytosis (causes) 1- Viral infection: 2- Some* bacterial -
Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW Clare M
Published OnlineFirst August 29, 2017; DOI: 10.1158/1078-0432.CCR-17-1144 Biology of Human Tumors Clinical Cancer Research Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW Clare M. Adams1, Ramkrishna Mitra1, Jerald Z. Gong2, and Christine M. Eischen1 Abstract Purpose: B-cell lymphomas must acquire resistance to apopto- follicular, mantle cell, marginal zone, and Hodgkin lymphomas. sis during their development. We recently discovered BCLW, an Notably, BCLW was preferentially overexpressed over that of antiapoptotic BCL2 family member thought only to contribute to BCL2 and negatively correlated with BCL2 in specific lymphomas. spermatogenesis, was overexpressed in diffuse large B-cell lym- Unexpectedly, BCLW was overexpressed as frequently as BCL2 in phoma (DLBCL) and Burkitt lymphoma. To gain insight into the follicular lymphoma. Evaluation of all five antiapoptotic BCL2 contribution of BCLW to B-cell lymphomas and its potential to family members in six types of B-cell lymphoma revealed that confer resistance to BCL2 inhibitors, we investigated the expres- BCL2, BCLW, and BCLX were consistently overexpressed, whereas sion of BCLW and the other antiapoptotic BCL2 family members MCL1 and A1 were not. In addition, individual lymphomas in six different B-cell lymphomas. frequently overexpressed more than one antiapoptotic BCL2 Experimental Design: We performed a large-scale gene family member. expression analysis of datasets comprising approximately Conclusions: Our comprehensive analysis indicates B-cell 2,300 lymphoma patient samples, including non-Hodgkin lymphomas commonly select for BCLW overexpression in andHodgkinlymphomasaswellasindolentandaggressive combination with or instead of other antiapoptotic BCL2 lymphomas. Data were validated experimentally with qRT- family members. Our results suggest BCLW may be equally as PCR and IHC. -
Non-Hodgkin Lymphoma
Non-Hodgkin Lymphoma Rick, non-Hodgkin lymphoma survivor This publication was supported in part by grants from Revised 2013 A Message From John Walter President and CEO of The Leukemia & Lymphoma Society The Leukemia & Lymphoma Society (LLS) believes we are living at an extraordinary moment. LLS is committed to bringing you the most up-to-date blood cancer information. We know how important it is for you to have an accurate understanding of your diagnosis, treatment and support options. An important part of our mission is bringing you the latest information about advances in treatment for non-Hodgkin lymphoma, so you can work with your healthcare team to determine the best options for the best outcomes. Our vision is that one day the great majority of people who have been diagnosed with non-Hodgkin lymphoma will be cured or will be able to manage their disease with a good quality of life. We hope that the information in this publication will help you along your journey. LLS is the world’s largest voluntary health organization dedicated to funding blood cancer research, education and patient services. Since 1954, LLS has been a driving force behind almost every treatment breakthrough for patients with blood cancers, and we have awarded almost $1 billion to fund blood cancer research. Our commitment to pioneering science has contributed to an unprecedented rise in survival rates for people with many different blood cancers. Until there is a cure, LLS will continue to invest in research, patient support programs and services that improve the quality of life for patients and families. -
Transformation of Follicular Lymphoma to Acute Lymphoblastic Leukemia
Transformation of Follicular Lymphoma to Acute Lymphoblastic Leukemia Xiaoping Sun, MD, PhD; Leo I. Gordon, MD; LoAnn C. Peterson, MD n March 1994, a 56-year-old man underwent lobectomy sies showed a single paratrabecular lymphoid aggregate I of the upper lobe of the right lung and lymph node that suggested involvement by the follicular lymphoma. dissection for poorly differentiated adenocarcinoma. Ma- During the next 6 years, the patient underwent 2 biopsies lignant lymphoma, follicular, small cleaved was identi®ed and 2 ®ne-needle aspiration biopsies of lymph nodes from in multiple paratracheal and hilar lymph nodes. Hema- different sites, and the results of all of these biopsies were toxylin-eosin±stained sections of the lymph nodes showed consistent with the initial diagnosis. Flow cytometric im- a follicular pattern and a predominance of small cleaved munophenotyping was performed on 3 of the lymph node lymphoma cells (Figure, A). Bilateral bone marrow biop- specimens, and all contained CD101 and CD52 clonal B cells (CD191 and CD201) with l surface immunoglobulin light chain restriction. In August of 1999, 5 years after the Accepted for publication March 1, 2002. initial diagnosis, repeated bilateral bone marrow biopsies From the Department of Pathology, Northwestern University Medical School, Chicago, Ill. showed a normocellular bone marrow with 2 nonparatra- Reprints: LoAnn C. Peterson, MD, Department of Pathology, North- becular lymphoid aggregates; these ®ndings were not di- western University Medical School, Feinberg Pavilion, Room 7-344, agnostic for lymphoma. Flow cytometry studies of the 251 East Huron St, Chicago, IL 60611 (e-mail: [email protected]). bone marrow showed no evidence of B-cell clonality. -
The Cytogenetics of Hematologic Neoplasms 1 5
The Cytogenetics of Hematologic Neoplasms 1 5 Aurelia Meloni-Ehrig that errors during cell division were the basis for neoplastic Introduction growth was most likely the determining factor that inspired early researchers to take a better look at the genetics of the The knowledge that cancer is a malignant form of uncon- cell itself. Thus, the need to have cell preparations good trolled growth has existed for over a century. Several biologi- enough to be able to understand the mechanism of cell cal, chemical, and physical agents have been implicated in division became of critical importance. cancer causation. However, the mechanisms responsible for About 50 years after Boveri’s chromosome theory, the this uninhibited proliferation, following the initial insult(s), fi rst manuscripts on the chromosome makeup in normal are still object of intense investigation. human cells and in genetic disorders started to appear, fol- The fi rst documented studies of cancer were performed lowed by those describing chromosome changes in neoplas- over a century ago on domestic animals. At that time, the tic cells. A milestone of this investigation occurred in 1960 lack of both theoretical and technological knowledge with the publication of the fi rst article by Nowell and impaired the formulations of conclusions about cancer, other Hungerford on the association of chronic myelogenous leu- than the visible presence of new growth, thus the term neo- kemia with a small size chromosome, known today as the plasm (from the Greek neo = new and plasma = growth). In Philadelphia (Ph) chromosome, to honor the city where it the early 1900s, the fundamental role of chromosomes in was discovered (see also Chap. -
Mature B-Cell Neoplasms
PEARLS OF LABORATORY MEDICINE Mature B-cell Neoplasms Michael Moravek, MD Kamran M. Mirza, MD, PhD Loyola University Chicago Stritch School of Medicine DOI: 10.15428/CCTC.2018.287706 © Clinical Chemistry The Lymphoid System Bone Marrow Stem Cell • Mature B-cell lymphomas comprise approximately 75% of all lymphoid neoplasms • Genetic alterations lead to deregulation of cell T cell Immature NK cell proliferation or apoptosis B cell • Low-grade lymphomas typically present as painless B cell lymphadenopathy, hepatosplenomegaly, or incidental lymphocytosis • High-grade lymphomas typically present with a rapidly enlarging mass and “B” symptoms (fever, weight loss, night sweats) Plasma cell 2 B-Cell Maturation antigen Naïve B cell Post- Germinal Center Germinal Center Marginal Zone DLBCL (some) FL, BL, some DLBCL, CLL/SLL Mantle Cell Hodgkin lymphoma MZL MALT Lymphoma Plasma cell myeloma CD5 + CD10 + CD5/CD10 Neg 3 Frequency among mature B-cell neoplasms DLBCL 27.6% CLL/SLL 19.4% Mature B-cell neoplasms Chronic lymphocytic leukemia/small lymphocytic lymphoma Primary cutaneous follicle center lymphoma Follicular Lymphoma -Monoclonal B-12.2%cell lymphocytosis Mantle cell lymphoma Marginal Zone LymphomaB-cell prolymphocytic 3.7% leukemia -Leukemic non-nodal mantle cell lymphoma Splenic marginal zone lymphoma -In situ mantle cell neoplasia Mantle Cell LymphomaHairy cell leukemia1.9% Diffuse large B-cell lymphoma (DLBCL), NOS Splenic B-cell lymphoma/leukemia, unclassifiable -Germinal center B-cell type Burkitt Lymphoma -Splenic diffuse1.3% red pulp