Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/ PS1 Transgenic Mice
ORIGINAL RESEARCH published: 14 July 2020 doi: 10.3389/fphar.2020.01045 Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/ PS1 Transgenic Mice † † Wei-Hui Hu 1,2,3 , Shing-Hung Mak 1,2 , Zhong-Yu Zheng 1,2, Ying-Jie Xia 1,2, Miranda Li Xu 1,2, Ran Duan 1,2,3, Tina Ting-Xia Dong 1,2,3, Shao-Ping Li 4, Chang-Sen Zhan 5,6, Xiao-Hui Shang 5,6 and Karl Wah-Keung Tsim 1,2,3* 1 Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen, China, 2 Division of Life Science and Center for Chinese Medicine and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, Hong Kong, 3 Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, China, 4 Institute of Chinese Medical Sciences, University of Macau, Macau, Macau, 5 Shanghai Edited by: Engineering Research Center for Innovation of Solid Preparation of TCM, Shanghai, China, 6 Shanghai Hutchison Qiaobing Huang, Pharmaceuticals Ltd., Shanghai, China Southern Medical University, China Reviewed by: Background: Shexiang Baoxin Pill (SBP), a formulated traditional Chinese medicine Bing-Xing Pan, Nanchang University, China (TCM), has been widely used to treat cardiovascular diseases for years. This herbal Wenda Xue, mixture has been shown to promote differentiation of cultured neuronal cells. Here, we Nanjing University of Chinese aimed to investigate the effects of SBP in attenuating cognitive impairment in APP/PS1 Medicine, China *Correspondence: transgenic mice.
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