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Cancerresearch CancerResearch VOLUME 32 AUGUST 1972 NUMBER 8 ICANCER RESEARCH 32, 1609—1646, August 1972] Standardized Nomenclature for Inbred Strains of Mice: Fifth Listing' Prepared by Joan Staats The Jackson Laboratory, Bar Harbor, Maine 04609 For The Committee on Standardized Genetic Nomenclature for Mice2 Previous issues of Standardized Nomenclature for Inbred and 232 in the fourth. Appendix 2 is a list of standard Strains of Mice appeared in CANCER RESEARCH in 1952 abbreviations for the names of persons or institutions (1), 1960 (2), 1964 (5), and 1968 (6). The wide demand for maintaining inbred strains. The principal use of these this compendium warrants its continuance. Between issues, abbreviations is in designating substrains. For example, additions and deletions to strain holdings appear in Mouse Deringer's HR strain, upon transfer to the Institute of Cancer News Letter (4) and Inbred Strains ofMice (3). Research, becomes HR/Delcr. Appendix 3 lists recommended Material in this issue is arranged in several sections, with a abbreviations for some of the more widely used inbred strains few changes in coverage or arrangement from previous issues. when coining hybrid designations or when brevity is desired There has been no change in the rules for designating inbred for other reasons. strains of mice since the Fourth Listing; therefore, those rules The Committee stresses the importance of using full strain have been omitted to save space. The data on biochemical or substrain designations in publications. The truncated polymorphisms are arranged in a table, both to avoid repeating symbol C57, for example, could refer to seven or eight long lines of alleles after each strain name and to make the different strains. Often it is sufficient to use the full material more conveniently accessible. designation under “Materialsand Methods― and the shorter Most fostered and otherwise manipulated lines, named genes symbol alone elsewhere in the text. The many well-established on inbred backgrounds, and congenic histocompatibility cases of differences between substrains emphasize the strains have been omitted, to keep the list to a manageable size necessity of using full designations. For example, CBA/J and to avoid duplication. Dr. Jan Klein of the University of carries the gene for retinal degeneration whereas CBA/Ca does Michigan is preparing a list of congenic strains, to be published not; the two differ in radiosensitivity, and they are not in Transplatztation. histocompatible. We also stress the importance of identifying Appendix 1 is the index list of inbred strains and some the sex of the parents when listing hybrids. It is customary to clearly defined substrains. It contains 244 entries, compared list the female first. Thus, C57BL/6J 9 X DBA/2J d is with 124 in the first issue, 202 in each of the second and third, B6D2F1 , and DBA/2J 9 X CS7BL/6J d is D2B6F1. 1 Address requests for reprints to Dr. Joan Staats, The Jackson Laboratory, Bar Harbor, Maine 04609; to Dr. A. G. Searle, M.R.C. REFERENCES Radiobiology Unit, Harwell, Didcot, Berks., United Kingdom; or to Dr. I. K. Egorov, Institute of General Genetics, USSR Academy of 1. Committee on Standardized Nomenclature for Inbred Strains of Sciences, Moscow B-133, USSR. Mice. Standardized Nomenclature for Inbred Strains of Mice. Cancer 2 The Committee: P. Démant, Institute of Experimental Biology and Genetics, Czechoslovak Academy of Sciences, Praha 4; I. K. Egorov, Res.,12:602—613,1952. Moscow; M. C. Green, The Jackson Laboratory; H. Gruneberg, 2. Committee on Standardized Genetic Nomenclature for Mice. University College London, 4 Stephenson Way, London, NW! 2HE; J. Standardized Nomenclature for Inbred Strains of Mice, Second J. Hutton, University of Kentucky, Lexington, Ky. 40506; K. Kondo, Listing. Cancer Res., 20: 145—169, 1960. Department of Animal Genetics, Nagoya University, Nagoya-shi; M. F. 3. Inbred Strains of Mice: An informal biennial document listing Lyon, Radiobiology Unit, Harwell, Didcot, Berks.; 1. H. Roderick, The laboratories maintaining inbred strains of mice; the companion Jackson Laboratory; M. Sabourdy, C.S.E.A.L., C.N.R.S., document to Mouse News Letter. It is prepared by Joan Staats and 45-Orleans-la-Source (ICLA representative); R. Schmidt, Biologisches distributed by The Jackson Laboratory, Bar Harbor, Maine. ISM #7 Institut, Halle-Saale; A. G. Searle, Radiobiology Unit, Harwell, Didcot, Berks.; J. Staats, The Jackson Laboratory. Preparation of this paper was appeared in July 1971 and contained contributions from 96 supported in part by Grant GB27487 from the National Science laboratories. Fo:indation. 4. Mouse News Letter: An informal semiannual document carrying Received and accepted April 1 1, 1972. information on mutant genes, research stocks of mice, and research AUGUST 1972 1609 Downloaded from cancerres.aacrjournals.org on September 28, 2021. © 1972 American Association for Cancer Research. JoanStaats news. There is a bibliographic supplement with each issue. MNL is A Inbr (St): 161. Genet: a, b, c. Origin: currently edited by A. G. Searle, distributed to the Western Strong, 1921 , from cross of Cold Spring Hemisphere and Japan by The Jackson Laboratory and to the rest of Harbor albino and Bagg albino. Majority of the world by the Laboratory Animals Centre, Carshalton, Surrey. sublines trace to a stock which Bittner MNL #46 appeared in February 1972. obtained from Strong in 1927. Charac: lung 5. Staats, J. Standardized Nomenclature for Inbred Strains of Mice, tumors in 9? 5.8%, leukemia in 99 7.2% Third Listing. Cancer Res., 24: 147—168, 1964. 6. Staats, J. Standardized Nomenclature for Inbred Strains of Mice, (Bin); relatively susceptible to GraffI Fourth Listing. Cancer Res., 28: 391—420,1968. leukemia agent (Bln); mammary cancer 80% in breeders, 30% in virgins (Ki); reticular tissue neoplasms 4% in breeders, 12% in dd APPENDIX 1 (Ki); no mammary tumors in virgins (H); few skeletal variants (Gr); high incidence of List of inbred strains of mice and their clearly defined renal disease in old animals; 40% of 99 have substrains. positive LE cells or antinuclear antibodies by 6 mo., complement not detectable (Umc); Abbreviations 84% neonatally thym'ectomized develop runting syndrome (Umc); high incidence of Inbr = number of generations of brother X sister lung tumors in virgins and breeders (Dm); inbreeding. The substrain on which the cleft lip and palate occur sporadically, easily figure is based is indicated in parentheses. If induced with a variety of agents. Maintained a line has been produced by appropriate by: A, Bcr, Dm, Gr, H, Icrf, Ki, Mann crosses to an inbred strain, the number of (Philadelphia), Miroff (Schenectady), Ph, Ss, generations is preceded by N. St, Sy, Tarkowsky (Warsaw), Tr, Umc, Wis, Woodruff (Edinburgh). Genet = genetic constitution, mainly mutant coat and eye colors. Genes for biochemical A/He Inbr (J): 153. Origin: Strong to Heston polymorphisms and histocompatibility are 1938, He to J 1948. Charac: lung tumors 5% listed in Table 1. in 99, leukemia 7% in 99 (Lac); 58% mammary tumors in breeders at 414 days, Origin = origin. In some cases references are given. A 12.3% primary lung tumors, 10.8% table in Chap. 1 of BLM-2 gives more hepatomas, 12.3% leukemias in breeders at extensive information. 550—650 days (Y); mammary tumors about 40%, high lung tumor, amyloid and nephritis BLM-2 = Green, E. L. (ed.). Biology of the (He), median life span 400 days (Advan. Laboratory Mouse, Ed. 2. New York: Genet., 16: 305, 1971), mean life span in McGraw-Hill, 1966. fostered SPF 99 558 days, @d512 days (Lab. Animals, 5: 179, 1971). Maintained Charac = characteristics. In some cases journal references are given. Letters in parentheses by: An!, Cam, Crgl, He, Ibg, Icr, J, Kun, Lac [SPF] , Mk, Ms, Mt, Mv [f] , N, Rank indicate specific contributions to Inbred Strains of Mice. The key to the letters will (MUnchen), Rl, Sn, Sto, We, Y. be found in Appendix 2. In a few cases information has been obtained by A/J Inbr (J): 150. Origin: see strain A. Strong to correspondence. Cloudman 1928, survivors of Bar Harbor fire to Jax 1947 at F73. Charac: spontaneous Maintained by = persons or laboratories maintaining each malformations: in newborn, 6.9% cleft lip strain, insofar as information is available, are with or without cleft palate, 7.6% open indicated by substrain symbols. eyelid(s) (4.2% in 99, 11.2% in dd), 0.5% preaxial polydactyly of hindfoot, 0.5% b X s = brother X sister inbreeding. isolated CP (Kt); fairly high incidence of lung tumors (Umc); mammary tumors in GF, SPF, f = germ-free, specific pathogen-free, fostered. 25% of breeders, primary lung tumors in Information on bacteriological status was 40% of dd, 30% of 99 (J. Nat!. Cancer Inst., supplied by the holder of the strain as of 36: 921 , 1966); lower percentage of April 1971 . For example, the Radiobio granulocytes than other A sublines (Proc. logical Institute TNO has two lines of C3Hf, Soc. Exptl. Biol. Med., 78: 761, 1951); high one maintained under conventional condi incidence of renal disease in older animals. tions and one maintained under germ-free Blood pressure lowest of 8 strains tested conditions. This appears as “Rij[cony. & (Nature, 212: 5 19, 1966). Uniformly GFI.― susceptible to P. berghei infection (Military 1610 CANCER RESEARCH VOL.32 Downloaded from cancerres.aacrjournals.org on September 28, 2021. © 1972 American Association for Cancer Research. Standardized Nomenclature for Inbred Strains of Mice Med., 131: 915, 1966). Very sensitive to by Furth as a high leukemia strain from X-irradiation (BLM-2); some heart lesions in 1928 to 1936, then random-bred at old breeders (BLM-2); moderately Rockefeller Inst. for several generations. b X susceptible to audiogenic seizures over a long S mated 9 gen. by Mrs. Rhoades and 2 1 by period up to 245 days (J.
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