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Drug-Induced Diseases

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Drug-Induced Diseases INDEX Figures and tables are indicated by “f” and “t” following page numbers. AAD. See Antibiotic-associated diarrhea delirium and, 326t morbidity and mortality for, 956 AAN (American Academy of Neurology), 264–265 hirsutism and, 194, 195t, 199t overview, 955 Abacavir neutropenia/agranulocytosis and, 1089t patient education on, 957 acidosis and, 1003t ototoxicity and, 1234t prevention of, 956–957 allergic and hypersensitivity reactions to, 75t, peripheral neuropathy and, 281t risk factors for, 956 88, 112 photosensitivity and, 144t Acute kidney injury (AKI), 941–960 anxiety and, 400t, 403 tardive dyskinesia and, 265 acute interstitial nephritis, 955–957 cutaneous diseases and, 111t, 113t taste disorders and, 1259t, 1261t acute tubular necrosis, 949–955 genetic variability and, 16t visual disturbances and, 296t community-acquired, 941–942, 944 genetic variations affecting, 36t Acetohydroxamic acid, 1066t, 1070t defined, 941 glucose/insulin dysregulation and, 690 Acetylcholine glomerulonephritis, 958–960 human leukocyte antigen and, 37, 38 cognitive disorders and, 359, 360 hemodynamic-mediated, 942–949 malignant hyperthermia and, 1186 delirium and, 329 hospital-acquired, 941–942 myocardial ischemia/acute coronary syndromes myocardial ischemia/acute coronary syndromes nephrolithiasis, 957–958 and, 472t and, 473t Acute lymphoblastic leukemia (ALL), 1283, 1286, nausea/vomiting and, 909t myopathy and, 1153 1291 neutropenia/agranulocytosis and, 1089t psychosis and, 418 Acute myeloid leukemia (AML), 1283–1287, oral erythema multiforme and, 1266t sexual dysfunction and, 766 1289–1292 osteoporosis/osteomalacia and, 1127 in sleep cycles, 349 Acute tubular necrosis (ATN), 949–955 ototoxicity and, 1234t Acetylcholinesterase inhibitors, 335 causative agents of, 943t, 949–950 pharmacogenomic tests for, 35 Acetylcysteine, 440, 1243 clinical presentation of, 946t, 951 Abatacept, 1270t Acetyl-L-carnitine, 286, 287t, 288 differential diagnosis of, 951 Abciximab, 238t, 239, 1029t, 1050t, 1052t, 1053 Acetylsalicylic acid. See Aspirin epidemiology of, 950 Abiraterone, 698t, 836t Acid–base disorders. See Acidosis; Alkalosis management of, 955 Absolute neutrophil count (ANC), 1087, 1092, 1094, Acidosis, 1001–1011 mechanisms of, 950–951 1096 anion gap metabolic, 1002t, 1004t, 1007t morbidity and mortality for, 952 ABVD regimen, 1285, 1286, 1291 causative agents of, 1001, 1002–1003t patient education on, 955 Acebutolol clinical presentation of, 1005–1007, 1006t prevention of, 952–955 alopecia and, 168t differential diagnosis of, 1006, 1007t risk factors for, 951–952 hypotension and, 632t, 638t epidemiology of, 1001 Acyclovir, 168t, 196t, 944–945t, 957, 967, 1188t, photosensitivity and, 144t ketoacidosis, 1002t, 1004t 1191, 1295 sinus bradycardia/atrioventricular block and, 577t lactic, 1002t, 1004, 1004t, 1007–1008, 1010–1011 Adalimumab systemic lupus erythematosus and, 124t, 128t, management of, 1008–1011, 1009f, 1010t, 1011f alopecia and, 173t 132 mechanisms of, 1001, 1004–1005, 1004t depression and, 383 ACE inhibitors. See Angiotensin-converting enzyme morbidity and mortality for, 1007 hepatic/cholestatic diseases and, 852t inhibitors patient education on, 1011 interstitial lung disease/pulmonary fibrosis and, Acenocoumarol, 1029t prevention of, 1007–1008, 1008t 433t Acetaminophen renal tubular, 1003–1004t, 1004, 1006, 1010, 1011f oral erythema multiforme and, 1266t acidosis and, 1002t respiratory, 1001, 1003–1004t, 1005–1007, oral lichenoid reactions and, 1270t asthma/bronchospasm and, 452t, 453, 455t, 461 1007–1008t, 1010–1011 serum sickness-like reactions and, 1193t chronic kidney disease and, 968–970, 973, 976 risk factors for, 1007, 1008t sexual dysfunction and, 761t cutaneous diseases and, 101, 102–103t Acitretin, 166, 173t, 791, 1273 skin cancer and, 1297 drug interactions with, 39 Acne, 102t, 105, 107t, 108, 114, 114t, 384 systemic lupus erythematosus and, 126t hemolytic anemia and, 1105t ACOG (American College of Obstetricians and thyroid diseases and, 698–699t, 701t, 710 hepatic/cholestatic diseases and, 846t, 853, 856, Gynecologists), 626, 1302, 1303 valvular/pericardial heart disease and, 660t, 662 864–866 Aconite, 573t visual disturbances and, 296t hypothermia and, 1216 Aconite alkaloids, 524–525t, 525 Addison disease, 734–735 myocardial ischemia/acute coronary syndromes ACTH. See Adrenocorticotropic hormone Adefovir, 966, 966t, 970t, 1003t, 1050t and, 489 Actinomycin, 847t, 907t Adenosine neutropenia/agranulocytosis and, 1089t Activated charcoal, 245, 580, 587–588, 701t, 1039 acute kidney injury and, 951, 953 oral erythema multiforme and, 1266t Acute akathisia. See Akathisia atrial fibrillation/atrial flutter and, 581, 582–583t, ototoxicity and, 1233, 1234–1235t Acute coronary syndromes. See Myocardial 583–586, 585t pancreatitis and, 878t, 881 ischemia/acute coronary syndromes atrial tachycardia and, 591 peripheral neuropathy and, 288 Acute dystonia. See Dystonia AV node re-entrant tachycardia and, 594 smoking and, 32 Acute hypertension, 232, 240 hypotension and, 644 teratogenicity of, 1321, 1326 Acute interstitial nephritis (AIN), 955–957 monomorphic ventricular tachycardia and, thrombocytopenia and, 1050t, 1052t causative agents of, 943t, 956 524–525t, 525–526 vaginal bleeding disorders and, 797 clinical presentation of, 946t, 956 myocardial ischemia/acute coronary syndromes Acetate, 1013–1014t differential diagnosis of, 956 and, 472t, 477t, 479 Acetazolamide epidemiology of, 956 sinus bradycardia/atrioventricular block and, acidosis and, 1003t management of, 957 570t, 573t, 577–579 aplastic anemia and, 1100t mechanisms of, 945t, 956 structural similarities with hydralazine, 127 1343 Unauthenticated | Downloaded 09/27/21 02:57 PM UTC INDEX ADHD (attention deficit/hyperactivity disorder) differential diagnosis of, 257, 257t Alendronate agents, 219t, 221–222, 401 epidemiology of, 254–255 atrial fibrillation/atrial flutter and, 581, 582t, 584 Adjuvant chemotherapy, 1167–1169t, 1172, 1173t management of, 258–259, 259t hepatic/cholestatic diseases and, 848t Adolescents. See Pediatric patients mechanisms of, 255–256, 256t osteonecrosis of jaw and, 1274t Ado-trastuzumab, 169t, 836t morbidity and mortality for, 258 osteoporosis/osteomalacia and, 1129t, 1130 Adrenal diseases. See Hypothalamic, pituitary, and overview, 253–254 upper gastrointestinal ulceration and, 812–814, adrenal diseases patient education on, 259 816, 818 Adrenergic β-receptor blockers. See β-adrenergic prevention of, 258, 258t visual disturbances and, 296t receptor blockers (β-blockers) risk factors for, 258, 258t Alfalfa, 144t Adrenocorticotropic hormone (ACTH) AKI. See Acute kidney injury Alfentanil, 906t Cushing syndrome and, 731t, 732 Alanine aminotransferase (ALT), 859, 862, 868, Alfuzosin, 296t, 472t, 632t, 639t, 1050t, 1234t cutaneous diseases and, 108 1058 Aliskiren, 633t, 638t, 942 hirsutism and, 194, 195t, 199t Albiglutide, 879t Alitretinoin, 144t hypersensitivity reactions to, 77t Albumin, 364, 784, 787, 868–871, 1242 Alkaline phosphatase (ALP), 859, 862 pancreatitis and, 882 Albuterol Alkalosis, 1012–1018 primary adrenal insufficiency and, 735 acidosis and, 1002t causative agents of, 1012, 1013t secondary adrenal insufficiency and, 735, 741 anxiety and, 404 clinical presentation of, 1014–1015, 1015t stimulation test for, 738 atrial fibrillation/atrial flutter and, 582t, 584 differential diagnosis of, 1015, 1016t synthesis of, 729 atrial tachycardia and, 588–589t, 589 epidemiology of, 1012 Adverse drug reactions (ADRs). See also Drug- AV node re-entrant tachycardia and, 592–594, management of, 1016–1017, 1018f, 1018t induced diseases 592–594t mechanisms of, 1012–1014, 1014t allergies. See Drug allergies myocardial ischemia/acute coronary syndromes morbidity and mortality for, 1015–1016 categorization of, 23, 59–60 and, 473t patient education on, 1017 causality/correlation in, 23 psychosis and, 416t, 418t respiratory, 1012–1017, 1013–1016t differential diagnosis of, 51, 63–65 teratogenicity of, 1320 risk factors for, 1015, 1017t documentation of, 65–66 visual disturbances and, 296t Alkylating agents drug–drug interactions, 38–40, 39t Alcohol use chemotherapy-induced anemia and, 1101t, 1109, food–drug interactions, 40–41 anxiety and, 409 1109t gender differences in, 31–32 atrial fibrillation/atrial flutter and, 581, 582–583t, infertility and, 783t, 786t, 800 hospital admissions due to, 28 584–586, 585–586t leukemia and, 1284, 1289, 1290 hypersensitivity. See Drug hypersensitivity Brugada syndrome and, 547, 547t, 549 neutropenia/agranulocytosis and, 1087, 1091 reactions (DHRs) cognitive disorders and, 362 sexual dysfunction and, 767, 770 manifestations of, 19 delirium and, 326t, 330, 337 vaginal bleeding disorders and, 782t, 785t in medication histories, 60, 62 diarrhea and, 825, 827 ALL (acute lymphoblastic leukemia), 1283, 1286, mortality associated with, 29 duration of detection in urine, 420t 1291 Naranjo Scale for, 64, 65, 65t gout/hyperuricemia and, 1139, 1146 Allergic-mediated blood disorders, 75t, 80, 83–84, in new drug approval process, 48 heart failure and, 516 83t 9 points of consideration for, 63–64 hepatic/cholestatic diseases and, 864 Allergic reactions. See Drug allergies postmarketing surveillance for. See Postmarketing hyperprolactinemia and, 744t Allodynia, 1141 surveillance hypertrichosis and, 197t Allopurinol prevalence of, 4 hypotension and, 643, 648 acute kidney injury and, 943–944t, 957 probability ratings for, 64, 64–65t, 65 intracerebral hemorrhage and, 238–240, 238t, allergic and hypersensitivity reactions to, 74–75t, quantitative
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