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Research in Your Backyard Developing Cures, Creating Jobs

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Research in Your Backyard Developing Cures, Creating Jobs Research in Your Backyard Developing Cures, Creating Jobs PHARMACEUTICAL CLINICAL TRIALS IN ILLINOIS Dots show locations of clinical trials in the state. Executive Summary This report shows that biopharmaceutical research com- Quite often, biopharmaceutical companies hire local panies continue to be vitally important to the economy research institutions to conduct the tests and in Illinois, and patient health in Illinois, despite the recession. they help to bolster local economies in communities all over the state, including Chicago, Decatur, Joliet, Peoria, At a time when the state still faces significant economic Quincy, Rock Island, Rockford and Springfield. challenges, biopharmaceutical research companies are conducting or have conducted more than 4,300 clinical For patients, the trials offer another potential therapeutic trials of new medicines in collaboration with the state’s option. Clinical tests may provide a new avenue of care for clinical research centers, university medical schools and some chronic disease sufferers who are still searching for hospitals. Of the more than 4,300 clinical trials, 2,334 the medicines that are best for them. More than 470 of the target or have targeted the nation’s six most debilitating trials underway in Illinois are still recruiting patients. chronic diseases—asthma, cancer, diabetes, heart dis- ease, mental illnesses and stroke. Participants in clinical trials can: What are Clinical Trials? • Play an active role in their health care. • Gain access to new research treatments before they In the development of new medicines, clinical trials are are widely available. conducted to prove therapeutic safety and effectiveness and compile the evidence needed for the Food and Drug • Obtain expert medical care at leading health care Administration to approve treatments. Clinical tests of facilities during the trial. new drugs are conducted in three phases and account for • Help others by contributing to medical research. seven of the 10 to 15 years required for drug development and approval. Patient Safety in Clinical Trials Clinical trials involve thousands of volunteer patient participants, • All tests must be reviewed and approved by an the generation of tens of thousands of pages of technical and sci- Institutional Review Board (IRB), an independent entific data and are responsible for 45 to 75 percent of the $1.2 committee of physicians, statisticians, local billion average cost of developing one new cutting-edge biotech- community advocates and others to ensure a trial is nology medicine. ethically conducted and patient rights are protected. 2 PhRMA • PHARMACEUTICAL CLINICAL TRIALS IN ILLINOIS • Clinical trial progress reports must be submitted at • North Shore University Medical Center in Skokie least annually to the Food and Drug Administration • Northwestern University Feinberg School of and the IRB. Medicine in Chicago • All facilities that conduct or support biomedical • Rush University in Chicago research involving patients must comply with federal regulations and have an IRB. • Southern Illinois University Medical Center in Springfield Many different entities and individuals contribute to the • The University of Chicago Medical Center in safe and appropriate conduct of clinical research, includ- Chicago ing not only sponsoring companies but also regulatory agencies; investigative site staff and medical profession- The biopharmaceutical research companies working with als who serve as clinical investigators; hospitals and other these institutions have targeted disease wisely—more than institutions where research is conducted; and institutional half of Illinois’s new medicine clinical trials are aimed at review boards and ethics committees. chronic conditions that plague patients all over the state, Local Involvement including cancer, diabetes, heart disease and stroke. Illinois institutions involved in clinical tests of treatments There are 474 clinical trials recruiting patients all over include medical schools, research centers and hospitals, the state. These trials target the top six chronic diseases— such as: asthma, cancer, diabetes, heart disease, mental illness and stroke. • Rush University Medical Center in Chicago • Cedar-Crosse Research Center in Chicago Equally as important is the fact that many of the medi- cines being clinically tested here are new-generation • Loyola University Medical Center in Maywood biotechnology treatments. With biotechnology, we have • Decatur Memorial Hospital Cancer Institute in the potential to develop safer and more effective therapies Skokie and we can improve our ability to predict, preempt or even prevent disease. Economic Impact of Clinical Trials in Illinois since 1999— Biopharmaceutical Companies Completed and Active Earlier reports show biopharmaceutical research compa- All Clinical Trials Six Major Chronic Diseases nies have been an important source of jobs, tax revenue and research spending: 4,395 2,334 • A study by Archstone Consulting found that in Source: www.clinicaltrials.gov 2008 the industry supported more than 167,000 Note: Search criteria = Illinois, Phase I, II, III; industry only. jobs throughout the state. Search performed 2/1/2012. DEVELOPING CURES, CREATING JOBS • A PARTNERSHIP BETWEEN BIOPHARMACEUTICAL COMPANIES AND STATE RESEARCH INSTITUTIONS 3 • The employees working directly for the companies were paid $2.8 billion, leading to more than $75 million in state taxes and more “At a time when the state is focused on creating than $710 million in federal taxation. jobs and rebuilding the economy, clinical • Biopharmaceutical research firms that year research and the biopharmaceutical industry also invested $2.3 billion in research and have been real bright spots. These companies development and provided $43.9 billion in provide thousands of good-paying jobs, and to products and services. the extent they succeed in finding innovative • Company employees in Illinois include life medicines, they make the entire workforce sciences researchers, management executives, office and administrative support workers, stronger and more productive.” engineers, architects, computer and math experts and sales representatives. —David Miller, President and CEO iBIO (Illinois Biotechnology Industry Organization) Clinical Trials in Illinois Communities Location Asthma Cancer Diabetes Heart Disease Mental Illness Stroke Chicago 4 28 35 22 30 11 Decatur 0 18 0 0 0 0 Joliet 0 15 1 3 10 0 Peoria 0 19 4 4 2 2 Quincy 0 11 2 2 0 2 Rock Island 0 1 0 2 0 1 Rockford 0 4 0 2 0 1 Springfield 1 12 10 4 4 3 Source: www.clinicaltrials.gov Note: Search criteria = Illinois, Phase I, II, II; industry only. Search performed 2/1/2012. See Appendix for detailed information about these clinical trials. Disease columns will not add to totals in Appendix because some clinical trials are recruiting in more than one city. 4 PhRMA • PHARMACEUTICAL CLINICAL TRIALS IN ILLINOIS Many of these medicines are being tested today in clinical “As part of our mission to improve trials throughout Illinois. quality of life for people living with lung disease, Respiratory Health Association of At a time when tens of thousands of state residents are Metropolitan Chicago devotes significant suffering from one or more chronic diseases, America’s biopharmaceutical research companies are sponsoring resources each year to funding research. or have sponsored 2,334 clinical trials of potential new Through support of investigators at local medicines in the Prairie State alone for asthma, cancer, institutions including Northwestern University, heart disease, stroke, diabetes and mental illnesses. Of University of Chicago and University of Illinois the 2,334 trials, 474 are either not yet recruiting or are at Chicago, we hope to develop interventions, just now seeking Illinois patients, giving those still search- improve treatments and discover cures for ing for effective treatments potential new options and lung diseases.” new hope. —Joel Africk, President and Chief Executive Officer Many of the state’s clinical tests involve collaborations Respiratory Health Association of Metropolitan Chicago with such respected local institutions as the Loyola Uni- versity’s Medical Center in Maywood, the North Shore University Health System in Evanston, the University of Chicago and the University of Illinois in Chicago. The Need for New Chronic Disease Medicines Clinical Trials for Top Chronic Diseases Chronic diseases pose the greatest threats to our nation’s Clinical Trials health and our ability to treat and prevent medical condi- Chronic Disease All Clinical Trials tions. According to the Centers for Disease Control and Still Recruiting Prevention, today, in the United States: Asthma 74 11 • Patients with chronic diseases account for 75 cents Cancer 1,294 303 of every dollar spent on health care. • Chronic diseases are the leading cause of death Diabetes 293 41 and disability. Heart Disease 210 30 • Chronic diseases are a leading driver of rising Mental Illness 422 78 health care costs with expenses totaling billions of dollars every year. Stroke 41 11 Total 2,334 474 With the stakes so high, America’s biopharmaceutical research companies are developing new medicines to help Source: www.clinicaltrials.gov treat those conditions that are taking an unprecedented Note: Search criteria = Illinois, Phase I, II, III; industry only. Search performed 2/1/2012. toll on American lives. DEVELOPING CURES, CREATING JOBS • A PARTNERSHIP BETWEEN BIOPHARMACEUTICAL COMPANIES AND STATE RESEARCH INSTITUTIONS
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