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2018 Annual Report

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2018 Annual Report Welcome to the 2018 Annual Report "The NTP serves a critical role for our nation. It provides a unique, consolidated venue for toxicology research, testing, and analysis to occur." – Dr. Linda Birnbaum, NIEHS and NTP Director Read the 2018 Letter from the NIEHS and NTP Director. FY 2018 at a Glance Learn About Us Scientific and Public Input Opportunities Completed NTP Reports and About NTP Publications Organizational Structure and NTP Board of Scientific NTP Public Health Impact Oversight Counselors Brian Berridge Takes the Helm Interagency Agreements SACATM at the National Toxicology Funding Scientific Panels Program More More More Research and Testing Literature Analysis Partner Agency Research Tox21 Noncancer Research NTP at NIEHS Testing and Toxicology Report on Carcinogens NTP at NCTR Studies NTP at NIOSH NICEATM ICCVAM The NTP Annual Report is produced by the NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Annual Report in a publication, please provide us a copy for our records. We welcome your comments and suggestions. Official Citation: National Toxicology Program. Annual Report for Fiscal Year 2018. Research Triangle Park, NC: National Toxicology Program; 2019. Available from https://ntp.niehs.nih.gov/annualreport/2018 Director of Office of Liaison, Policy, and Review and Editor -in -Chief: Mary Wolfe | Managing Editor: Joshua Cleland (ICF) 2018 Annual Report – Contents Contents Contents .............................................................................................................................................. 3 Letter from the NIEHS and NTP Director ........................................................................................... 6 FY 2018 at a Glance ............................................................................................................................ 7 FY 2018 Timeline............................................................................................................................... 9 Completed NTP Reports and Publications ...................................................................................... 12 Publications during FY 2018 ........................................................................................................................ 12 NTP Public Health Impact ................................................................................................................ 13 Use of NTP Study Data or Recommendations by Federal and State Health Regulatory and Research Agencies in FY 2018 .................................................................................................................................... 13 Brian Berridge Takes the Helm at the National Toxicology Program ............................................... 17 Tox Challenge – Stage Two Winners Announced ........................................................................... 18 New Roadmap Guides Progress toward Replacing Animal Use ..................................................... 19 NTP Releases Findings from Two CLARITY-BPA Study Components ........................................... 20 NTP Cell Phone Studies – Experts Recommend Elevated Conclusions ......................................... 21 Federal Partners Put Tox21 Plan into Action ................................................................................... 22 NTP Framework for Innovation Rolled Out at Board Meeting .......................................................... 23 ICCVAM Publishes 2016–2017 Biennial Report .............................................................................. 24 PFAS in the Spotlight across the Globe ........................................................................................... 25 Additional Activities .......................................................................................................................... 26 Learn About Us ................................................................................................................................. 27 About NTP ....................................................................................................................................... 28 Organizational Structure and Oversight ........................................................................................... 29 Interagency Agreements .................................................................................................................. 30 FDA/NCTR ................................................................................................................................................... 30 CDC/NIOSH ................................................................................................................................................. 30 NIH/NCATS/DPI ........................................................................................................................................... 30 DOE/ORNL .................................................................................................................................................. 31 EPA/NCCT ................................................................................................................................................... 31 EPA/NCEA ................................................................................................................................................... 31 NIST ............................................................................................................................................................ 31 Funding ............................................................................................................................................ 32 NIEHS Contracts That Supported NTP Activities in FY 2018 ....................................................................... 32 Program Contact Information ........................................................................................................... 34 Scientific and Public Input Opportunities ....................................................................................... 35 NTP Board of Scientific Counselors ................................................................................................. 36 NTP Board of Scientific Counselors Membership Roster FY 2018 ............................................................... 37 3 2018 Annual Report – Contents SACATM .......................................................................................................................................... 38 SACATM Membership Roster FY 2018 ........................................................................................................ 39 Scientific Panels .............................................................................................................................. 40 NTP Technical Reports Peer Reviewed in FY 2018 ..................................................................................... 40 NTP Research Reports Peer Reviewed in FY 2018 ..................................................................................... 40 NTP Report on Carcinogens Monographs Peer-Reviewed in FY 2018 ........................................................ 41 Training Opportunities ..................................................................................................................... 42 NIEHS/NTP Training Program Postdoctoral Fellows in FY 2018 .................................................................. 42 Research and Testing ....................................................................................................................... 43 Tox21 ............................................................................................................................................... 44 Testing and Toxicology Studies ....................................................................................................... 52 About Testing and Toxicology Studies ......................................................................................................... 53 Disposition, Metabolism, and Toxicokinetic Studies ..................................................................................... 54 Genetic Toxicity Studies ............................................................................................................................... 56 Organ System Toxicity Studies .................................................................................................................... 61 Modified One-Generation Reproduction Studies .......................................................................................... 65 Toxicology and Carcinogenicity Studies ....................................................................................................... 67 Toxicogenomic Studies ................................................................................................................................ 73 NICEATM ........................................................................................................................................ 77 About NICEATM .......................................................................................................................................... 78 NICEATM Webinars and Workshops ........................................................................................................... 79 NICEATM Support of Tox21 .........................................................................................................................
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