Targeting Human Mas-Related G Protein-Coupled Receptor X1 To
Targeting human Mas-related G protein-coupled PNAS PLUS receptor X1 to inhibit persistent pain Zhe Lia,1, Pang-Yen Tsenga,1, Vinod Tiwarib,1, Qian Xua, Shao-Qiu Heb, Yan Wanga, Qin Zhenga, Liang Hana, Zhiping Wuc,d, Anna L. Blobaume, Yiyuan Cuif, Vineeta Tiwarib, Shuohao Suna, Yingying Chenga, Julie H. Y. Huang-Lionnetb, Yixun Genga, Bo Xiaof, Junmin Pengc,d,g, Corey Hopkinse, Srinivasa N. Rajab, Yun Guanb,2, and Xinzhong Donga,h,2 aThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; bDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; cDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105; dDepartment of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38105; eDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Specialized Chemistry Center, Vanderbilt University Medical Center, Nashville, TN 37232; fThe State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; gSt. Jude Proteomics Facility, St. Jude Children’s Research Hospital, Memphis, TN 38105; and hHoward Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Edited by Robert J. Lefkowitz, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, and approved January 30, 2017 (received for review September 12, 2016) Human Mas-related G protein-coupled receptor X1 (MRGPRX1) is a Animal studies suggest that a potential drug target is the MRGPRC promising target for pain inhibition, mainly because of its re- in trigeminal ganglia and DRG (6, 20, 21).
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