DOCSLIB.ORG

LIFE EXTENSION June 2007 Congress Seeks to Ban DHEA by William Faloon

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
LIFE EXTENSION June 2007 Congress Seeks to Ban DHEA by William Faloon LIFE EXTENSION June 007 Congress Seeks to Ban DHEA By William Faloon A bill has been introduced in Congress that would classify DHEA as an “anabolic steroid drug” and thus make it illegal for Americans to obtain. DHEA, however, is not an anabolic steroid drug. It is a natural hormone that declines as people mature past the age of 30. Low DHEA levels have been related with degenerative conditions associated with aging.1-28 A large volume of published scientific studies reveals that supplemental DHEA can provide unique health benefits.29-62 For more than a decade, DHEA has been sold as a dietary supplement. The availability of DHEA supplements has enabled many aging Americans to avoid the risks associated with declining DHEA levels. It is in the financial interests of pharmaceutical companies to have DHEA banned so that aging people will have to rely instead on expensive prescription drugs. If Congress is persuaded by drug lobbyists to outlaw DHEA supplements, more Americans will become vulnerable to declining DHEA levels, resulting in an economic bonanza for pharmaceutical companies. In this report, we expose shocking facts behind this new attack on DHEA so that citizens will be armed with the information they need to dissuade Congress from prohibiting this lifesaving hormone. > > > June 007 LIFE EXTENSION On March 5, 2007, legislation was introduced that would add dehydro- epiandrosterone, or DHEA, to the list of anabolic steroids that are classi- fied as controlled substances under the Anabolic Steroid Control Act.63 DHEA, a natural hormone, does not function like muscle-building anabolic steroid drugs. In fact, no scientific studies indicate that DHEA increases muscle mass in young men with already-adequate DHEA levels. To frighten the public into thinking that DHEA poses a danger, a blatantly false press release is now circulating in Congress. Here is an excerpt from this press release: “Like all steroids, DHEA has a number of potential long-term physical and psychological effects, including heart disease, cancer, stroke, liver damage, severe acne, baldness, dramatic mood swings, and aggression.” 64 This same study analyzed the tional profits from cardiac drugs if As you will read next, these alle- relationship of DHEA, free testoster- Congress bans DHEA supplements. gations are totally inconsistent with one, and insulin-like growth factor-1 Pharmaceutical lobbying has the scientific literature. Even more (IGF-1) to mortality in men suffering already curtailed Americans’ access disturbing is that a basis for this new from chronic heart failure. The chart to inexpensive ways to boost testos- attack on DHEA comes from those below reveals the startling results terone and IGF-1, though certain who have a huge financial interest in when these three hormones were nutrients have been shown to boost turning DHEA into an expensive pre- correlated with three-year survival: IGF-1 and testosterone in some scription drug. studies.53,68,70 Three-Year DHEA Protects Against Heart Hormone Survival Cardiac Dangers Associated Disease—It Does Not Cause It! Status Rate with Low DHEA Drugs to prevent and treat heart High levels of Epidemiological studies show that disease generate more profit for DHEA, testosterone, low levels of DHEA in men correlate pharmaceutical companies than any and IGF-1 83% with a higher risk of cardiovascular other class of medication. The use of disease. The Massachusetts Male DHEA as a dietary supplement has Deficiency in one Aging Study followed 1,700 men been increasing as new studies reveal hormone (DHEA, between the ages of 40 and 70 for that DHEA might reduce heart attack testosterone, or IGF-1) 74% nine years. The authors found that 7-10,12,26,27,65-69 risk. Pharmaceutical com- Deficiency in two men in the lowest quartile of serum panies thus face huge economic hormones (DHEA, DHEA at baseline were 60% more losses if too many Americans use low- testosterone, or IGF-1) 55% likely to develop ischemic heart dis- cost DHEA supplements and reduce ease, suggesting a valuable role for their reliance on expensive cardiac Deficiency in all DHEA in averting the nation’s lead- drugs. three hormones (DHEA, ing cause of death.9 To give you an idea of the magni- testosterone, and IGF-1) 27% Additionally, higher DHEA levels tude of loss faced by drug companies, seem to positively affect endothe- a study published in October 2006 The doctors who conducted this lial cell signaling, which could have showed that higher DHEA levels study concluded that a deficiency in important implications for avoid- resulted in improved ejection frac- any of these hormones is “an inde- ing heart disease. In a subset of men tions (a measurement of the heart’s pendent marker of poor prognosis.” from the Baltimore Longitudinal pumping capacity) and lower levels Based on this one study alone, Study of Aging, levels of hormones of a blood marker that indicates seri- pharmaceutical companies stand (including DHEA) were measured ous congestive heart failure.26 to earn billions of dollars of addi- and correlated with arterial stiffness LIFE EXTENSION June 007 (using ultrasound imaging of the Another animal study simulated carotid arteries). Men with higher the depressed cardiovascular func- levels of testosterone and DHEA had tion (shock) that follows major less stiffness of the arteries, indicat- trauma.72 In response to adminis- ing a decreased risk of cardiovascular tration of a DHEA metabolite, the events such as heart attacks.65 depression of cardiovascular func- A similar link between low serum tion and organ blood flow induced by DHEA levels and greater risk for shock was reversed. The dangerous carotid artery disease was demon- inflammatory cytokine interleukin- strated last year in a study of young 6 (IL-6), which had been elevated women with polycystic ovary syn- in the state of simulated shock, was drome, a condition associated with also reduced by this DHEA metabo- an increased risk of cardiovascular lite. The investigators concluded disease and metabolic syndrome.71 that treatment with this metabolite Congress Seeks A study in animals in 2006 shed could be valuable in restoring car- further light on how DHEA promotes diovascular function and correcting To Ban DHEA: cardiovascular health.66 Researchers abnormal cytokine levels. What You Need to Know fed young and old female mice a Furthermore, investigators deter- daily DHEA supplement. After 60 mined that DHEA injected directly • A bill recently introduced in Congress days of treatment, the investigators into the coronary arteries of pigs would classify the popular supple- measured the stiffness of the test ani- produced acute dilation of the blood ment dehydroepiandroesterone (DHEA) mals’ left ventricle, the heart’s major vessels, with associated increases in as an anabolic steroid drug. If the pumping chamber. The DHEA-sup- coronary blood flow.67 proposed bill becomes law, DHEA plemented older mice had decreased would be regulated as a controlled left ventricular stiffness compared DHEA Protects Against substance and would no longer be to the non-supplemented older Atherogenic Risk Factors readily available as a nutritional animals. supplement. The scientists concluded that A number of studies indicate • DHEA is not an anabolic steroid drug, DHEA supplementation is capable that DHEA helps protect aging but rather a natural hormone that is of reversing the left ventricular stiff- adults against atherosclerosis and essential for good health. Since DHEA ness that accompanies aging, thus its life-threatening consequences, levels in the human body decline promoting youthful structure and such as coronary artery dis- after the age of 0, many people rely function in the heart’s tissues. ease.7-10,26,27,31,32,65,68,69,73-75 Several mecha- on DHEA supplements to combat nisms of action may account for these diseases associated with aging. A wealth of research demonstrates SEN. HATCH TO OPPOSE DHEA BAN benefits. In a controlled trial, 24 older men that optimal DHEA levels can help orally ingested 50 mg of DHEA or a protect against heart disease, cogni- Sen. Orrin Hatch (R-UT), who was placebo at bedtime for two months. tive decline, and premature death. instrumental in the passage of the 199 The researchers then measured • Those seeking to ban DHEA claim Dietary Supplement and Health Education arterial dilation and blood flow. that it causes many adverse effects Act (DSHEA) and remains one of Congress’ While the placebo-treated sub- in the body, including mood swings staunchest advocates of health freedom, jects had no changes in any of the and liver toxicity. However, no sub- told Life Extension that he opposes S. 76 parameters measured, the DHEA- stantial scientific evidence exists to and other efforts to re-classify DHEA as an treated men experienced increased support these claims; in fact, in the anabolic steroid. levels of a substance that helps blood more than 10 years that DHEA has According to Hatch, the proposed leg- vessels to dilate, as well as decreas- been available as a dietary supple- islation “specifically overturns the exemp- ing levels of a marker for blood ment, there have been no reports of tion we made for DHEA.” The senator notes clotting. They also had lower serious adverse health effects related that DHEA was exempted from the list of levels of artery-clogging low- to DHEA. banned anabolic steroids under DSHEA density lipoprotein (LDL) after • If DHEA becomes a controlled because “there is no evidence that DHEA treatment than did the controls. substance, Americans will have has posed any health problem.” Based on the beneficial effects of lost a valuable weapon for averting “In fact, [DHEA] is being used safely by short-term DHEA treatment, the the diseases of aging. To preserve many Americans who recognize its poten- researchers concluded that long- your freedom to use DHEA and other tial,” says Sen.
Load more

Recommended publications
  • Pharmaceutical Sciences
    IAJPS 2017, 4 (08), 2671 - 2680 V.L.Sravani et al ISSN 2349 - 7750 CODEN [USA]: IAJPBB ISSN: 2349 - 7750 I N D O A M E R I C A N J O U R N A L O F P H A R M A C E U T I C A L S C I E N C E S Available online at: http://www.iajps.com Research Article ANTI - ACNE ACTIVITY OF LIPIDO - STEROLIC EXTRACT OF SERENOA REPENS AND HYDRO - ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA IN SYRIAN HAMSTER EAR MODEL V. Laxmi Sravani 1 *, Dr. B. Ch a n drasekhar Rao 1 , Dr. D. Ravi Krishna Babu 2 1 Department of Pharma cology, RGR Siddhanthi College of Pharmacy , Secundera bad. 2 Aurigene Discovery Technologies Pvt Ltd. Miyapur, Hyderabad. Abstract : Acne vulgaris is the most commonly encountered dermatological disease of pilosebaceous unit. Androgens, which increase during puberty, stimulate the sebaceous gland to produce sebum and cause retention of keratinocytes around the sebaceous hair follicle orifice causing partial to complete blockage and leading to colonization with Propionibacterium acnes, which participates in the production of pro inflammatory mediators. For treatment of acne one of the approaches is to reduce sebum production, the main stimulus to acne; then all other pathogenic factors will diminish. A comprehensive approach combining the natural medicine with anti - androgenic activity would be fruitful area for anti - acne therapy. In this context the well documented anti - androgenic herbs like liquorice and saw palmetto were selected and screened in Syrian hamster ear model using spironolactone as standard.
    [Show full text]
  • THE BARRON REPORT Volume 7, Issue 6 © 1999, Jon Barron
    THE BARRON REPORT Volume 7, Issue 6 © 1999, Jon Barron. All Rights Reserved. Health For Every Man Over 30 The Prostate Problem Like women, men too are exposed to the effects of chemical estrogens in their environment. In addition, as their testosterone levels drop with age, there is, in many cases, a concomitant rise in estradiol levels -- the major reason that many older men develop breasts. Just as with women, estradiol stimulates cell growth in men too and is potentially cancerous. Estradiol stimulates the BCL2 gene, which is the gene responsible for stopping cell death. What at first glance sounds like a positive, is, upon closer inspection, not. When cell death in prostate tissue, for example, is blocked, cell growth continues unabated -- becoming a major contributing factor in the enlargement of the prostate and the development of prostate cancer. This is one of the main factors involved in the dramatically increased incidence of prostate cancer. • A new case of Prostate Cancer is diagnosed every 3 minutes in America and every 15 minutes a man dies from prostate cancer. • Prostate Cancer is the second leading type of cancer among men. • 11 million men have some form of Prostate Cancer in the United States. • African-American men have the highest rate of Prostate Cancer in the world. • Survival rates for men with prostate cancer in 1995 were no different than they were in 1965. • The age at which Prostate Cancer develops will drop ten years by the year 2000. By the year 2000, Prostate Cancer will increase by 90%. The Prostate Solution Regular use of a men's progesterone crememakes a great deal of sense for any man over the age of 30.
    [Show full text]
  • The 5ARI Withdrawal Syndrome (5ARI-WS)
    The 5ARI Withdrawal Syndrome (5ARI-WS) The Silenced Androgen Receptor (AR) Theory: Explaining persistent side effects arising from 5alpha reductase (5AR) inhibitor (5ARI) use By “Awor” and “Mew”, Administrators of Propeciahelp.com (July 2010) 1. Introduction An increasingly overwhelming amount of evidence is starting to accumulate from various doctors, scientists, patient groups and online discussion forums, whereby seemingly unrelated substances such as finasteride, dutasteride, isotretinoin and saw palmetto extract (SPE) based preparations are causing young consumers to suffer from long-term, irreversible and serious health damage. The experienced persistent side effect have a clear denominator in that they all seem to relate to physiological and psychological functions which require androgens to function correctly: Loss of libido (1) (2) Low energy, fatigue (1) Depression (including suicidal depression)* (3) (4) (5) (6) Impaired thought processes* (7) Memory failure* (7) Erectile dysfunction (8) (9) (2) Penile atrophy (9) Impaired spermatogenesis (10) (11) (12) Muscle wasting (13) (14) (15) Gynecomastia (16) Dry skin and dry eyes (17) (18) (19) Prostate problems (2) Metabolic syndrome (20) Osteoporosis (21) (22) Anxiety and sleep disorders, muscle spasms (23) (24) (25) * Indirect action through 3α-HSD as described later in this document Of substantial note is that most side effects typically surface or reach full extent roughly 10-14 days after quitting the 5ARI substances. Androgen dependent tissue atrophy (penile, scrotum,
    [Show full text]
  • Beta-Sitosterol [BSS] and Betasitosterol Glucoside [BSSG] As an Adjuvant in the Treatment of Pulmonary Tuberculosis Patients.” TB Weekly (4 Mar 1996)
    Saw Palmetto (Serenoa repens) and One of Its Constituent Sterols -Sitosterol [83-46-5] Review of Toxicological Literature Prepared for Errol Zeiger, Ph.D. National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709 Contract No. N01-ES-65402 Submitted by Raymond Tice, Ph.D. Integrated Laboratory Systems P.O. Box 13501 Research Triangle Park, North Carolina 27709 November 1997 EXECUTIVE SUMMARY The nomination of saw palmetto and -sitosterol for testing is based on the potential for human exposure and the limited amount of toxicity and carcinogenicity data. Saw palmetto (Serenoa repens), a member of the palm family Arecaceae, is native to the West Indies and the Atlantic Coast of North America, from South Carolina to Florida. The plant may grow to a height of 20 feet (6.10 m), with leaves up to 3 feet (0.914 m) across. The berries are fleshy, about 0.75 inch (1.9 cm) in diameter, and blue-black in color. Saw palmetto berries contain sterols and lipids, including relatively high concentrations of free and bound sitosterols. The following chemicals have been identified in the berries: anthranilic acid, capric acid, caproic acid, caprylic acid, - carotene, ferulic acid, mannitol, -sitosterol, -sitosterol-D-glucoside, linoleic acid, myristic acid, oleic acid, palmitic acid, 1-monolaurin and 1-monomyristin. A number of other common plants (e.g., basil, corn, soybean) also contain -sitosterol. Saw palmetto extract has become the sixth best-selling herbal dietary supplement in the United States. In Europe, several pharmaceutical companies sell saw palmetto-based over-the-counter (OTC) drugs for treating benign prostatic hyperplasia (BPH).
    [Show full text]
  • Baus Section of Oncology the British Prostate Group
    Prostate Cancer and Prostatic Diseases (2006 ) 9, 310 –335 & 2006 Nature Publishing Group All rights reserved 1365-7852/06 $30.00 www.nature.com/pcan BAUS SECTION OF ONCOLOGY THE BRITISH PROSTATE GROUP PROSTATE CANCER – A MEETING OF MINDS FINAL ABSTRACTS Manchester International Convention Centre 24th – 26th November 2004 Abstracts British Prostate Group Does increasing the number of cores of prostate biopsy Anorectal dysfunction after 3-D conformal radiotherapy for 311 improve diagnostic accuracy? Indications and morbidity localised prostate cancer Kapasi F, Chandrasekar P, Barber C, Samman R, Dickon Hayne, Nula Allen, Dan Ashdown, Amanda Mellon, Potluri B and Virdi J. John Glaholm, Mike Foster Good Hope Hospital, Birmingham, Methods A study was conducted on accurate data maintained on 400 Introduction: patients who underwent transrectal ultrasound (TRUS) guided Previous work (Ref 1, 2) has shown a very high incidence of prostate biopsy. Patients were divided into three groups anorectal side effects with associated changes on anorectal depending on the number of cores and each group was physiology following conventional radiotherapy for localised subdivided into two based on the PSA level (PSA<20 & prostate cancer (CaP). We report early results on the first PSA>20). TRUS biopsy procedure was carried out using B and prospective study aiming to identify symptoms and quantify K medical ultrasound scanner no. 2002 (Panther Unit) using anorectal dysfunction after 3-D conformal radiotherapy (3D- Biplanor rectal probe (8551). An 18G, 20cm biopsy needle CRT) for CaP. (Biopty gun) was used. Patients & methods: Intravenous Gentamicin 120mg, Metronidazole 500mg Ethical approval was obtained from the North Birmingham suppository given at the time of procedure, followed by oral Regional Ethics Committee.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,486,374 B2 Tamarkin Et Al
    USOO8486374B2 (12) United States Patent (10) Patent No.: US 8,486,374 B2 Tamarkin et al. (45) Date of Patent: Jul. 16, 2013 (54) HYDROPHILIC, NON-AQUEOUS (56) References Cited PHARMACEUTICAL CARRIERS AND COMPOSITIONS AND USES U.S. PATENT DOCUMENTS 1,159,250 A 11/1915 Moulton 1,666,684 A 4, 1928 Carstens (75) Inventors: Dov Tamarkin, Maccabim (IL); Meir 1924,972 A 8, 1933 Beckert Eini, Ness Ziona (IL); Doron Friedman, 2,085,733. A T. 1937 Bird Karmei Yosef (IL); Alex Besonov, 2,390,921 A 12, 1945 Clark Rehovot (IL); David Schuz. Moshav 2,524,590 A 10, 1950 Boe Gimzu (IL); Tal Berman, Rishon 2,586.287 A 2/1952 Apperson 2,617,754 A 1 1/1952 Neely LeZiyyon (IL); Jorge Danziger, Rishom 2,767,712 A 10, 1956 Waterman LeZion (IL); Rita Keynan, Rehovot (IL); 2.968,628 A 1/1961 Reed Ella Zlatkis, Rehovot (IL) 3,004,894 A 10/1961 Johnson et al. 3,062,715 A 11/1962 Reese et al. 3,067,784. A 12/1962 Gorman (73) Assignee: Foamix Ltd., Rehovot (IL) 3,092.255. A 6, 1963 Hohman 3,092,555 A 6, 1963 Horn 3,141,821 A 7, 1964 Compeau (*) Notice: Subject to any disclaimer, the term of this 3,142,420 A 7/1964 Gawthrop patent is extended or adjusted under 35 3,144,386 A 8/1964 Brightenback U.S.C. 154(b) by 1180 days. 3,149,543 A 9, 1964 Naab 3,154,075 A 10, 1964 Weckesser 3,178,352 A 4, 1965 Erickson (21) Appl.
    [Show full text]
  • Coaching for Prostate Cancer
    P A A C T, I N C. PROSTATE CANCER COMMUNICATION P PROSTATE CANCER COMM UNI CATI ON NEW SLETTER • VOLUM E 2 2, NUM BER 2 • Sep t em b er 2 00 6 FOUNDER: LLOYD J. NEY, SR. – FOUNDED 1984 President and Chairperson: WHAT THE HECK HAS BEEN GOING ON IN MY WORLD- Janet E. Ney PART 12!!! By Mark A. Moyad, M.D., M.P.H. Board of Directors: PISTONS DO NOT RULE! That is all I need to say about that - by the time Edwin Kuberski you read this article I will have finished professional mental therapy for the Treasurer second year in a row because the Pistons blew it in the playoffs. Well, there is always the Michigan football season in a few months (time to restart therapy). Newton Dilley Helen Mellema 71) I heard you are on ABC radio every Saturday from 11AM to Noon! Peter Noor Jr. Richard H. Profit Jr. Was I drinking a lot of pomegranate juice that day or are you really on Anthony Staicer this show? The show is called “The Doctor is in” with Dr. Mark Moyad and Stephen Stewart. If you go to WJR.com on Saturday mornings at 11AM to Noon East- Honorary Board Member: ern Standard time you can listen to the show live anywhere in the world on your computer. In the Midwest the radio dial is 760 AM and it is the same sta- Russell Osbun tion my father listened to when I was a kid (neat stuff)! It is a 1-hour general prevention and nutrition show and I have no idea how long it will last.
    [Show full text]
  • Supporting Evidence, Potential Adverse Effects, and Known Drug
    ISSN: 2469-5742 Deol et al. Int Arch Urol Complic 2018, 4:047 DOI: 10.23937/2469-5742/1510047 Volume 4 | Issue 2 International Archives of Open Access Urology and Complications RESEARCH ARTICLE Supporting Evidence, Potential Adverse Effects, and known Drug Interactions of the Complementary Alternative Medicines which are Frequently used by Prostate Cancer Patients Harmeet Deol1, Alan Truong2, Tibebe Woldemariam3, Xiaodong Feng3 and Ruth Vinall3* 1PGY1 Resident, Corpus Christi Medical Center, USA 2Pharmacy student, California Northstate University College of Pharmacy (CNUCOP), Elk Grove, USA Check for 3Associate Professor, California Northstate University College of Pharmacy (CNUCOP), Elk Grove, USA updates *Corresponding author: Ruth Vinall, Associate Professor, California Northstate University College of Pharmacy (CNUCOP), Elk Grove, CA 95757, USA Abstract tory, and race (it is more common in African American A significant number of prostate cancer patients use com- plementary alternative medicines (CAMs) as an adjunct to men) [1]. In 2015, there were approximately 1,735,350 their conventional treatment. Examples of CAMs that are new cases diagnosed and it is estimated that 11.6% of frequently used by prostate cancer patients include green men will be diagnosed with PC at some point during tea extract, lycopene, and pomegranate fruit extract. In their lifetime [2]. Advances in early detection and treat- many cases there is little if any clinical study-based evi- dence to support the efficacy of CAMs in this setting, and, ment have contributed to improved patient outcomes; importantly, some CAMs can cause serious adverse effects in 1980 the 5-year survival rate was ~70.2%, the most when taken a high doses and/or have significant drug in- recent statistics estimate 5-year survival at 99.0% [2,3].
    [Show full text]
  • Saw Palmetto Serenoa Repens (W
    Clinical Overview Saw Palmetto Serenoa repens (W. Bartram) Small (syn. Sabal serrulata [Michx.] Nutt. ex Schult. & Schult. f.; Serenoa serrulata (Michx.) G. Nichols.) [Fam. Arecaceae] OVERVIEW NOTE:Most clinical studies have been Since the mid-1990s, saw palmetto has conducted with native extract. been one of the 10 top-selling herbs in the CONTRAINDICATIONS U.S. Total sales in mainstream retail stores in 2000 in the U.S. were over $43 million, Saw palmetto is contraindicated in ranking saw palmetto sixth in total herb advanced BPH with severe urinary sales. In Europe, saw palmetto extract is the retention. It should not be used without most commonly used phytotherapeutic first ruling out prostate cancer. agent for benign prostatic hyperplasia PREGNANCY AND LACTATION: Due to (BPH) and it is one of the most frequently potential hormonal activity, saw palmetto prescribed botanical preparations in is not recommended for pregnant or Germany. Saw palmetto berry was com- lactating women, although the herb is monly recommended for various prostatic seldom used by women. conditions by healthcare professionals in the early part of the 20th century. It was an ADVERSE EFFECTS official drug, listed in the United States Gastrointestinal disturbance occurs rarely. Pharmacopeia from 1906 to 1916 and in Ingestion of large amounts of saw palmetto the National Formulary from 1926 to 1950. berries may cause diarrhea, while ingestion In the 20th century, the United States of saw palmetto on an empty stomach may cause nausea. Hypertension was reported Dispensatory, 23rd edition, included saw Saw Palmetto palmetto as a treatment for enlargement of in 3.1% of patients taking the saw ® the prostate gland.
    [Show full text]
  • Prescription for Drug Alternatives All-Natural Options for Better Health Without the Side Effects
    ffirs.qxp 7/28/08 7:15 PM Page i Prescription for Drug Alternatives All-Natural Options for Better Health without the Side Effects JAMES F. BALCH, M.D. MARK STENGLER, N.D. ROBIN YOUNG BALCH, N.D. John Wiley & Sons, Inc. flast.qxp 7/28/08 7:16 PM Page viii ffirs.qxp 7/28/08 7:15 PM Page i Prescription for Drug Alternatives All-Natural Options for Better Health without the Side Effects JAMES F. BALCH, M.D. MARK STENGLER, N.D. ROBIN YOUNG BALCH, N.D. John Wiley & Sons, Inc. ffirs.qxp 7/28/08 7:15 PM Page ii Copyright © 2008 by J&R Balch, Inc., and Stenglervision, Inc. All rights reserved Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmit- ted in any form or by any means, electronic, mechanical, photocopying, recording, scan- ning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authoriza- tion through payment of the appropriate per-copy fee to the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 646-8600, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6008, or online at http://www.wiley.com/go/ permissions.
    [Show full text]
  • Saw Palmetto Extract Laboratory Guidance Document
    Saw Palmetto Extract Laboratory Guidance Document By Stefan Gafner, PhD* American Botanical Council, PO Box 144345, Austin, TX 78714 Serenoa repens *Correspondence email Photo ©2019 Steven Foster Keywords: Adulteration, animal fatty acids, canola oil, coconut oil, palm oil, saw palmetto, Serenoa repens, sunflower oil, vegetable oil Citation (JAMA) style: Gafner S. Saw palmetto extract laboratory guidance document. Austin, TX: ABC-AHP-NCNPR Botanical Adulterants Prevention Program. 2019. 1. Purpose There is documented evidence of the adulteration of saw palmetto fruit extracts with a number of vegetable oils, such as canola (Brassica napus ssp. napus, Brassicaceae), coconut (Cocos nucifera, Arecaceae), olive (Olea europaea, Oleaceae), palm (Elaeis guineensis, Arecaceae), peanut (Arachis hypogaea, Fabaceae), and sunflower (Helianthus annuus, Asteraceae) oils. The partial or complete substitution of saw palmetto fruit extracts with mixtures of fatty acids of animal origin was first documented in 2018,1 and seems particularly common in materials sold as saw palmetto originating from China. This Laboratory Guidance Document (LGD) presents a review of the various analytical technologies used to differentiate between authentic saw palmetto extracts and ingredients containing adulterating materials. This document can be used in conjunction with the Saw Palmetto Botanical Adulterants Bulletin, rev. 3, published by the ABC-AHP-NCNPR Botanical Adulterants Prevention Program in 2018.2 2. Scope does not reduce or remove the responsibility of laboratory Various analytical methods are reviewed here with the personnel to demonstrate adequate method performance specific purpose of identifying their strengths and limita- in their own laboratories using accepted protocols. Such tions in differentiating saw palmetto fruit extracts from protocols are outlined in the United States Food and Drug potentially adulterating materials.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 7,166,300 B1 Dascalu (45) Date of Patent: Jan
    USOO71663 OOB1 (12) United States Patent (10) Patent No.: US 7,166,300 B1 Dascalu (45) Date of Patent: Jan. 23, 2007 (54) AGENT FOR INDUCING HAIR GROWTH EP O 640 333 A2 3, 1995 CONTAINING EXTRACTS OF SAW EP O640333 A2 * 3, 1995 PALMETTO AND SWERTIA JP 63. 27.5514 A 11, 1988 JP 63. 303913. A 12, 1988 (75) Inventor: Avi Dascalu, Tel-Aviv (IL) JP 09 10O220 A 4f1997 JP 4O910O220 A * 4f1997 (73) Assignee: Medidermis Ltd., Netanya (IL) WO WO9702041 A1 * 1, 1997 (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 OTHER PUBLICATIONS U.S.C. 154(b) by 77 days. Great American Products, “Hair Maximizer Solutions Program”. pp. 1-3.* (21) Appl. No.: 10/111,659 Effect of Retinoids on Follicular Cells, G. Bazzano et al., Journal of Investigative Dermatology, vol. 101, No. 1 Supp., Jul. 1993, pp. (22) PCT Filed: Oct. 19, 2000 138S-142S. Studies on Active Substances in Herbs. Used for Hair Treatment. I. (86). PCT No.: PCT/LOO/OO660 Effects of Herb Extracts on Hair Growth and Isolation of an Active Substance from Polyporus umbellatus F. Y. Inaoka et al., Chem. S 371 (c)(1), Phar. Bull. vol. 42, No. 3, 1994, pp. 530-533. Apr. 25, 2002 Topical Minoxidil Therapy for Androgenetic Alopecia, J. A. (2), (4) Date: Koperski et al., Arch Dermtol, vol. 123, Nov. 1987, pp. 1483-1487. SULTAN, Inhibition Of Androgen Metabolism And Binding By. A (87) PCT Pub. No.: WO01/30311 Liposterolic Extract Of "Serenoa Repens B" In Human Foreskin PCT Pub.
    [Show full text]