Structural Basis for Nonneutralizing Antibody Competition at Antigenic
Structural basis for nonneutralizing antibody PNAS PLUS competition at antigenic site II of the respiratory syncytial virus fusion protein Jarrod J. Mousaa, Marion F. Sauerb, Alexander M. Sevyb, Jessica A. Finnc, John T. Batesa, Gabriela Alvaradoc, Hannah G. Kinga, Leah B. Loerinca, Rachel H. Fongd, Benjamin J. Doranzd, Bruno E. Correiae, Oleksandr Kalyuzhniye, Xiaolin Wenf, Theodore S. Jardetzkyf, William R. Schiefe, Melanie D. Ohig, Jens Meilerh, and James E. Crowe Jr.a,c,i,1 aVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232; bChemical and Physical Biology Program, Vanderbilt University Medical Center, Nashville, TN 37232; cDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232; dIntegral Molecular, Inc., Philadelphia, PA 19104; eDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037; fDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; gDepartment of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232; hDepartment of Chemistry, Vanderbilt University, Nashville, TN 37232; and iDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 Edited by Rino Rappuoli, GSK Vaccines, Siena, Italy, and approved September 20, 2016 (received for review June 10, 2016) Palivizumab was the first antiviral monoclonal antibody (mAb) rearrangement, resulting in fusion of the viral and cell mem- approved for therapeutic use in
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