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List of Principal Investigator(s) and Sub-Investigator(s) per study site where patients were enrolled Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Royal Prince Alfred Hospital Diabetes Centre Missenden Road 036001 Ho Jean Sub-Investigator/Co-Investigator MBBS, PhD Camperdown 2050 NSW AUSTRALIA Royal Prince Alfred Hospital Diabetes Centre Missenden Road 036001 Ross Glynis Sub-Investigator/Co-Investigator MBBS Camperdown 2050 NSW AUSTRALIA Royal Prince Alfred Hospital Diabetes Centre Missenden Road 036001 Wong Jencia Sub-Investigator/Co-Investigator MBBS, PhD Camperdown 2050 NSW AUSTRALIA

*CV provided as attachment to this appendix for all principal investigators Ensure that the printed copy of this document is the current version available on the Intranet. Property of the Sanofi Group - strictly confidential

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Royal Prince Alfred Hospital Diabetes Centre Missenden Road 036001 Wu Ted Sub-Investigator/Co-Investigator MBBS, PhD Camperdown 2050 NSW AUSTRALIA Royal Prince Alfred Hospital Diabetes Centre Missenden Road 036001 Yue~xr1i Dennis Principal Investigator PhD, MBBS Camperdown 2050 NSW AUSTRALIA Box Hill Hospital 5 Arnold Street 036005 Gilfillan Christopher Sub-Investigator/Co-Investigator MBBS, PhD 3128 VIC AUSTRALIA Box Hill Hospital 5 Arnold Street 036005 Goh Sue Sub-Investigator/Co-Investigator MBBS 3128 VIC AUSTRALIA Box Hill Hospital 5 Arnold Street 036005 Kalra Balvinder Sub-Investigator/Co-Investigator MD 3128 VIC AUSTRALIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Box Hill Hospital 5 Arnold Street 3128 036005 Principal Investigator MBChB, MD Simpson~xr2i Richard VIC AUSTRALIA AUSTRALIA Box Hill Hospital 5 Arnold Street 036005 Watson Benjamin Sub-Investigator/Co-Investigator MBBS 3128 VIC AUSTRALIA Redcliffe Peninsula 7 Day Medical Centre Corner of Anzac Avenue and Boardman Road Kippa Ring 036006 Anderson Paul Sub-Investigator/Co-Investigator MBBS 4021 QLD AUSTRALIA Redcliffe Peninsula 7 Day Medical Centre Corner of Anzac Avenue and Boardman Road Kippa Ring 036006 Principal Investigator MBBS Day~xr 3Peteri 4021 QLD AUSTRALIA Redcliffe Peninsula 7 Day Medical Centre Corner of Anzac Avenue and Boardman Road Kippa Ring 036006 Than Terence Sub-Investigator/Co-Investigator MBBS 4021 QLD AUSTRALIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Logan Central Medical Centre 1 Wembley Road Logan Central 036007 Brennan Glenn Sub-Investigator/Co-Investigator MBChB 4114 QLD AUSTRALIA Logan Central Medical Centre 1 Wembley Road Logan Central 036007 Principal Investigator MBBS Chupungco~xr4i Susan 4114 QLD AUSTRALIA Logan Central Medical Centre 1 Wembley Road Logan Central 036007 Then Edward Sub-Investigator/Co-Investigator MBBS 4114 QLD AUSTRALIA UZ Leuven Internal Medicine- Endocrinology Herestraat 49 056001 Benhalima Katrien Sub-Investigator/Co-Investigator MD Leuven 3000 BELGIUM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) UZ Leuven Internal Medicine- Endocrinology Herestraat 49 056001 Principal Investigator MD, PhD Mathieu~xr5i Chantal Leuven 3000 BELGIUM UZ Leuven Internal Medicine- Endocrinology Herestraat 49 056001 Vandistel Greet Sub-Investigator/Co-Investigator MD Leuven 3000 BELGIUM Erasme Hospital 808 Lennik Road 056005 Crenier~xr6i Laurent Principal Investigator MD Brussels 1070 BELGIUM Erasme Hospital 808 Lennik Road 056005 Kazakou Paraskevi Sub-Investigator/Co-Investigator MD Brussels 1070 BELGIUM UZ Brussel Laarbeeklaan 101 056006 De Cock Lyudmila Sub-Investigator/Co-Investigator MD Brussel 1090 BELGIUM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) UZ Brussel Laarbeeklaan 101 056006 Debroye Corinne Sub-Investigator/Co-Investigator MD Brussel 1090 BELGIUM UZ Brussel Laarbeeklaan 101 056006 Ghys Christophe Sub-Investigator/Co-Investigator MD Brussel 1090 BELGIUM UZ Brussel Laarbeeklaan 101 056006 Keymeulen~xr7i Bart Principal Investigator MD PhD Brussel 1090 BELGIUM UZ Brussel Laarbeeklaan 101 056006 Khorosheva Galina Sub-Investigator/Co-Investigator MD Brussel 1090 BELGIUM LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Principal Investigator MD Aronson~xr8i Ronnie M4G 3E8 Ontario CANADA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Boright Andrew Sub-Investigator/Co-Investigator MD M4G 3E8 Ontario CANADA LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Grossman Loren David Sub-Investigator/Co-Investigator MD M4G 3E8 Ontario CANADA LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Narula Priya Sub-Investigator/Co-Investigator BSc M4G 3E8 Ontario CANADA LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Sandler Samantha Sub-Investigator/Co-Investigator MD M4G 3E8 Ontario CANADA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Steen Oren Sub-Investigator/Co-Investigator MD M4G 3E8 Ontario CANADA LMC Diabetes & Endocrinology (Bayview) 1929 Bayview Avenue, Suite 107 Toronto 124001 Telner Adam Sub-Investigator/Co-Investigator MD M4G 3E8 Ontario CANADA BC Diabetes.ca 400-210 West Broadway 124002 Almehthel Mohammed Sub-Investigator/Co-Investigator MD Vancouver BC V5Y 3W2 CANADA BC Diabetes.ca 400-210 West Broadway 124002 Elliott~xr9i Thomas Principal Investigator MD Vancouver BC V5Y 3W2 CANADA BC Diabetes.ca 400-210 West Broadway 124002 Paty Breay Sub-Investigator/Co-Investigator MD Vancouver BC V5Y 3W2 CANADA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Okanagan Clinical Trials Ltd. 204-1353 Ellis Street Kelowna 124004 Evans Janet Sub-Investigator/Co-Investigator MD V1Y 1Z9 British Columbia CANADA Okanagan Clinical Trials Ltd. 204-1353 Ellis Street Kelowna 124004 Principal Investigator MD Godsell~xr10i Sally V1Y 1Z9 British Columbia CANADA Okanagan Clinical Trials Ltd. 204-1353 Ellis Street Kelowna 124004 Pagdin Grant Sub-Investigator/Co-Investigator MD V1Y 1Z9 British Columbia CANADA Centro Clinico Metabolico ESTORIL 120, Torre A, Oficina 812, Las Condes Santiago 152001 Oltra Maria Soledad Sub-Investigator/Co-Investigator MD 7591047 Region Metropolitana CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centro Clinico Metabolico ESTORIL 120, Torre A, Oficina 812, Las Condes Santiago 152001 Preiss Yudith Sub-Investigator/Co-Investigator MD 7591047 Region Metropolitana CHILE Centro Clinico Metabolico ESTORIL 120, Torre A, Oficina 812, Las Condes Santiago 152001 Principal Investigator MD Reyes~xr11i Eliana 7591047 Region Metropolitana CHILE CENTRO DE INVESTIGACION CLINICA Manuel Domingo Correa 15 Of.B, La Cisterna. Santiago 152002 Bustos Catalina Sub-Investigator/Co-Investigator MD 7980378 RM Region Metropolitan CHILE CENTRO DE INVESTIGACION CLINICA Manuel Domingo Correa 15 Of.B, La Cisterna. Santiago 152002 Cruz German Sub-Investigator/Co-Investigator MD 7980378 RM Region Metropolitan CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) CENTRO DE INVESTIGACION CLINICA Manuel Domingo Correa 15 Of.B, La Cisterna. Santiago 152002 Principal Investigator MD Lahsen~xr12i Rodolfo 7980378 RM Region Metropolitan CHILE Centro Biomed Ltda. Freire 360, block B, departamento 12 Temuco 152003 Principal Investigator MD Larenas~xr13i Gladys 4791301 Región de la Araucanía CHILE Centro Biomed Ltda Freire 360, block B, departamento 12 152003 Quininao Felipe Sub-Investigator/Co-Investigator MD Temuco 4791301Región de la Araucanía CHILE Centro Biomed Ltda Freire 360, block B, departamento 12 152003 Stockins Benjamin Sub-Investigator/Co-Investigator MD Temuco 4791301Región de la Araucanía CHILE Consulta Privada La Concepción 81, Oficina 216, Providencia Santiago 152004 Aguirre Loreto Sub-Investigator/Co-Investigator MD 7500010 Región Metropolitana CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Consulta Privada La Concepción 81, Oficina 216, Providencia Santiago 152004 Principal Investigator MD Solis~xr14i Carmen 7500010 Región Metropolitana CHILE Centro de investigaciones clinicas Atria Bosco Ltda (CICAB Ltda) Monseñor Felix Cabrera 14 oficina 62, Providencia 152006 Apablaza Pamela Sub-Investigator/Co-Investigator MD Santiago 7500021 Region Metropolitana CHILE Centro de investigaciones clinicas Atria Bosco Ltda (CICAB Ltda) Monseñor Felix Cabrera 14 oficina 62, Providencia 152006 Gomez~xr15i Patricia Principal Investigator MD Santiago 7500021 Region Metropolitana CHILE Centro de investigaciones clinicas Atria Bosco Ltda (CICAB Ltda) Monseñor Felix Cabrera 14 oficina 62, Providencia 152006 Roman Oscar Sub-Investigator/Co-Investigator MD Santiago 7500021 Region Metropolitana CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Corporación de Beneficencia Osorno Hermanos Philippi 1480 Osorno 152008 Potthoff Sergio Sub-Investigator/Co-Investigator MD 5311092 Región de los Lagos CHILE Corporación de Beneficencia Osorno Hermanos Philippi 1480 Osorno 152008 Principal Investigator MD Romero~xr16i Carmen 5311092 Región de los Lagos CHILE Centro MEDITEK Avenida Portugal 12, oficina 56, Santiago centro Santiago 152009 Principal Investigator MD Lobos~xr17i Sergio 8330008 Region Metropolitana CHILE Centro MEDITEK Avenida Portugal 12, oficina 56, Santiago centro Santiago 152009 Moreno Manuel Sub-Investigator/Co-Investigator MD 8330008 Region Metropolitana CHILE hospital de talagante Balmaceda 1458 152011 Saltos~xr18 iZoila Principal Investigator MD Talagante RM Region Metropolitan CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) hospital de talagante Balmaceda 1458 152011 Silva Veronica Sub-Investigator/Co-Investigator MD Talagante RM Region Metropolitan CHILE hospital de talagante Balmaceda 1458 152011 Trujillo Fernando Sub-Investigator/Co-Investigator MD Talagante RM Region Metropolitan CHILE Hospital y CRS El Pino Camino Padre Hurtado 13560, San Bernardo. Santiago 152012 Principal Investigator MD Cobos~xr19 iJorge 8053095 Region Metropolitana CHILE Hospital y CRS El Pino Camino Padre Hurtado 13560, San Bernardo. Santiago 152012 Grünberg Elbio Sub-Investigator/Co-Investigator MD 8053095 Region Metropolitana CHILE Centro de Investigacion Clinica del Sur Ltda Temuco 152014 Principal Investigator MD Barroso~xr20i Maria 4781156 Region de la Araucanía CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centro de Investigacion Clinica del Sur LtdaTemuco 152014 Danin~xr21i Alfredo Principal Investigator MD 4781156 Region de la Araucanía CHILE Centro de Investigacion Clinica del Sur LtdaTemuco 152014 Montero Marcela Sub-Investigator/Co-Investigator MD 4781156 Region de la Araucanía CHILE Quantum Research Dr. Otto Bader 810 Puerto Varas 152015 Tenorio María Sub-Investigator/Co-Investigator MD Región de los Lagos 5550170 CHILE Quantum Research Dr. Otto Bader 810 Puerto Varas 152015 Principal Investigator MD Toro~xr22i Lorena Región de los Lagos 5550170 CHILE Quantum Research Dr. Otto Bader 810 Puerto Varas 152015 Torres Claudia Sub-Investigator/Co-Investigator MD Región de los Lagos 5550170 CHILE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diahelp s.r.o. Poliklinika KOLF s.r.o. Masarykovo Namesti 2667 203001 Principal Investigator MD Divinec~xr23i Juraj Pardubice 530 02 CZECH REPUBLIC Diahelp s.r.o. Poliklinika KOLF s.r.o. Masarykovo Namesti 2667 203001 Dolezalova Barbora Sub-Investigator/Co-Investigator MD Pardubice 530 02 CZECH REPUBLIC Diabetologicka ambulance Slunecna 2101/2 203003 Dvořáková-Romanová Hana Sub-Investigator/Co-Investigator MD Praha 10 100 00 CZECH REPUBLIC Diabetologicka ambulance Slunecna 2101/2 203003 Houdova~xr24i Jana Principal Investigator MD Praha 10 100 00 CZECH REPUBLIC Medicentrum Beroun s.r.o. Diabetologicka ambulance Politickych veznu 40 203004 Buresova Ivana Sub-Investigator/Co-Investigator MD Beroun 266 01 CZECH REPUBLIC

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medicentrum Beroun s.r.o. Diabetologicka ambulance Politickych veznu 40 203004 Principal Investigator MD Raclavska~xr25i Lea Beroun 266 01 CZECH REPUBLIC Diabetologie a interna s.r.o Francouzska 4 203005 Kyselova Pavlina Sub-Investigator/Co-Investigator MD, PhD Plzen 326 00 CZECH REPUBLIC Diabetologie a interna s.r.o Francouzska 4 203005 Zemanova~xr26i Jitka Principal Investigator MD Plzen 326 00 CZECH REPUBLIC Diabetologicka, endokrinologicka a interni ambulance Na struze 30 203006 Principal Investigator MD Hejnicova~xr27i Katerina Trutnov 541 01 CZECH REPUBLIC Diabetologicka, endokrinologicka a interni ambulance Na struze 30 203006 Tichackova Jaroslava Sub-Investigator/Co-Investigator MD Trutnov 541 01 CZECH REPUBLIC

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetologicka ambulance - Medifin- zdravotni, s.r.o. Kartouzska 3274/10 203007 Halciakova Katarina Sub-Investigator/Co-Investigator MD Praha 5 150 00 CZECH REPUBLIC Diabetologicka ambulance - Medifin- zdravotni, s.r.o. Kartouzska 3274/10 203007 Principal Investigator MD Stehlikova~xr28i Stepanka Praha 5 150 00 CZECH REPUBLIC Privatni diabetologicka a interni ordinace Matice skolske 17 203008 Dohnal Pavel Sub-Investigator/Co-Investigator MD Ceske Budejovice 370 01 CZECH REPUBLIC Privatni diabetologicka a interni ordinace Matice skolske 17 203008 Dohnalova Jana Sub-Investigator/Co-Investigator MD Ceske Budejovice 370 01 CZECH REPUBLIC Privatni diabetologicka a interni ordinace Matice skolske 17 203008 Dohnalova~xr29i Lenka Principal Investigator MD Ceske Budejovice 370 01 CZECH REPUBLIC

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Vseobecna Fakultni Nemocnice V Praze III. interni klinika VFN a 1. LFUK U Nemocnice 1 203009 Anderlova Katerina Sub-Investigator/Co-Investigator MD Praha 2 12808128 08 CZECH REPUBLIC Vseobecna Fakultni Nemocnice V Praze III. interni klinika VFN a 1. LFUK U Nemocnice 1 203009 Flekac Milan Sub-Investigator/Co-Investigator MD,PhD Praha 2 12808128 08 CZECH REPUBLIC Vseobecna Fakultni Nemocnice V Praze III. interni klinika VFN a 1. LFUK U Nemocnice 1 203009 Principal Investigator MD Haluzik~xr30i Martin Praha 2 12808128 08 CZECH REPUBLIC Vseobecna Fakultni Nemocnice V Praze III. interni klinika VFN a 1. LFUK U Nemocnice 1 203009 Křížová Jarmila Sub-Investigator/Co-Investigator MD Praha 2 12808128 08 CZECH REPUBLIC

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Vseobecna Fakultni Nemocnice V Praze III. interni klinika VFN a 1. LFUK U Nemocnice 1 203009 Trachta Pavel Sub-Investigator/Co-Investigator MD Praha 2 12808128 08 CZECH REPUBLIC Interni a diabetologicka ambulance Therapon 98, a.s. Stefanikova 1301 203012 Principal Investigator MD Tomanek~xr31i Pavel Koprivnice 742 21 CZECH REPUBLIC Interni a diabetologicka ambulance Therapon 98, a.s. Stefanikova 1301 203012 Zabranska Alexandra Sub-Investigator/Co-Investigator MD Koprivnice 742 21 CZECH REPUBLIC Diabetologicka ordinace Axmanova 131 203013 Diepoltova~xr32i Barbora Principal Investigator MD Praha 9 - Klanovice 190 14 CZECH REPUBLIC Diabetologicka ordinace Axmanova 131 203013 Weichetova Marketa Sub-Investigator/Co-Investigator MD, PhD Praha 9 - Klanovice 190 14 CZECH REPUBLIC

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetologicka ambulance Komenskeho 49/6 203014 Skopecek~xr33i Jan Principal Investigator MD Horovice 268 01 CZECH REPUBLIC Adiamed, s.r.o., Diabetologicka ambulance Nemocnicni 945 203015 Golanova~xr34i Renata Principal Investigator MD Vsetin 755 01 CZECH REPUBLIC Diabetologicka ambulance Rybarska 1001 203016 Honzatkova Jana Sub-Investigator/Co-Investigator MD Ujezd U Brna 664 53 CZECH REPUBLIC Diabetologicka ambulance Rybarska 1001 203016 Nevrla~xr35 iJana Principal Investigator MD Ujezd U Brna 664 53 CZECH REPUBLIC Bispebjerg Hospital IC Forckning, indgang 11 B stuen Bispebjerg Bakke 23 208001 Bo Jansen Rasmus Sub-Investigator/Co-Investigator MD København Nv 2400 DENMARK

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Bispebjerg Hospital IC Forckning, indgang 11 B stuen Bispebjerg Bakke 23 208001 Hansen Caroline Raun Sub-Investigator/Co-Investigator MD København Nv 2400 DENMARK Bispebjerg Hospital IC Forckning, indgang 11 B stuen Bispebjerg Bakke 23 208001 Principal Investigator MD Perrild~xr36 iHans København Nv 2400 DENMARK Bispebjerg Hospital IC Forckning, indgang 11 B stuen Bispebjerg Bakke 23 208001 Svendsen Ole Lander Sub-Investigator/Co-Investigator MD København Nv 2400 DENMARK Kolding Hospital Forskningsenheden ved Medicinsk afdeling Skovvangen 2-8 208002 Duan Hongmei Sub-Investigator/Co-Investigator MD Kolding 6000 DENMARK

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Kolding Hospital Forskningsenheden ved Medicinsk afdeling Skovvangen 2-8 208002 Sadauskiene Laima Sub-Investigator/Co-Investigator MD Kolding 6000 DENMARK Kolding Hospital Forskningsenheden ved Medicinsk afdeling Skovvangen 2-8 208002 Principal Investigator MD Winther~xr37i Rasmussen Ole Kolding 6000 DENMARK Aarhus Universitetshospital, Nørrebrogade 44, bygning 2A, 1. sal MEA-KFA 208003 Principal Investigator MD Hansen~xr38i Troels Krarup Aarhus C 8000 DENMARK Aarhus Universitetshospital, Nørrebrogade 44, bygning 2A, 1. sal MEA-KFA 208003 Otten Klaus Sub-Investigator/Co-Investigator MD Aarhus C 8000 DENMARK

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Aarhus Universitetshospital, Nørrebrogade 44, bygning 2A, 1. sal MEA-KFA 208003 Skov Jeppe Sub-Investigator/Co-Investigator MD Aarhus C 8000 DENMARK Aarhus Universitetshospital, Nørrebrogade 44, bygning 2A, 1. sal MEA-KFA 208003 Østergaard Jakob Appel Sub-Investigator/Co-Investigator PhD,MD Aarhus C 8000 DENMARK Regionshospitalet Viborg Endokrinologisk ambulatorium Søndersøparken 14, 1. sal 208004 Helleberg Kjeld Sub-Investigator/Co-Investigator MD Viborg 8800 DENMARK Regionshospitalet Viborg Endokrinologisk ambulatorium Søndersøparken 14, 1. sal 208004 Shukla Atul Sub-Investigator/Co-Investigator MD Viborg 8800 DENMARK

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regionshospitalet Viborg Endokrinologisk ambulatorium Søndersøparken 14, 1. sal 208004 Principal Investigator MD Ostergard~xr39i Torben Viborg 8800 DENMARK Amager Hospital Med Amb, opgang 5, 2. sal Italiensvej 1 208005 Anholm Christian Sub-Investigator/Co-Investigator MD København S 2300 DENMARK Amager Hospital Med Amb, opgang 5, 2. sal Italiensvej 1 208005 Principal Investigator MD Frandsen~xr40i Hans København S 2300 DENMARK Regionshospitalet Horsens Diabetes ambulatoriet Sundvej 30, indgang A 208009 Crastens Marius Sub-Investigator/Co-Investigator PhD,MD Horsens 8700 DENMARK

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regionshospitalet Horsens Diabetes ambulatoriet Sundvej 30, indgang A 208009 Kaal Andreas Sub-Investigator/Co-Investigator MD Horsens 8700 DENMARK Horsens Sygehus Diabetes ambulatoriet Sundvej 30, indgang A 208009 Principal Investigator MD Moller~xr41i Marianne Kleis Horsens 8700 DENMARK Regionshospitalet Horsens Diabetes ambulatoriet Sundvej 30, indgang A 208009 Riis Anne Lene Sub-Investigator/Co-Investigator MD Horsens 8700 DENMARK SA Viljandi Haigla Sisekliinik Jämejala küla Pärna tee 3 233001 Kansi Helve Sub-Investigator/Co-Investigator MD Viljandimaa 71024 ESTONIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) SA Viljandi Haigla Sisekliinik Jämejala küla 233001 Ots Anneli Sub-Investigator/Co-Investigator MD Pärna tee 3 Viljandimaa 71024 ESTONIA SA Viljandi Haigla Sisekliinik Jämejala küla 233001 Toikka Berta Sub-Investigator/Co-Investigator MD Pärna tee 3 Viljandimaa 71024 ESTONIA SA Viljandi Haigla Sisekliinik Jämejala küla 233001 Vides~xr42i Hella Principal Investigator MD Pärna tee 3 Viljandimaa 71024 ESTONIA Liina Viitas OÜ Veetorni 2-1 233002 Lipmann Eha Sub-Investigator/Co-Investigator MD Pärnu 80018 ESTONIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Liina Viitas OÜ Veetorni 2-1 233002 Viitas~xr43 Liinai Principal Investigator MD Pärnu 80018 ESTONIA Mustamäe Tervisekeskus OÜ Sõpruse pst 179/181c 233003 Märtsin Kaja Sub-Investigator/Co-Investigator MD Tallinn 13415 ESTONIA Mustamäe Tervisekeskus OÜ Sõpruse pst 179/181c 233003 Virks~xr44i Anneli Principal Investigator MD Tallinn 13415 ESTONIA Vee Perearstikeskus Vee 6 233004 Alt~xr4 Ingrid5i Principal Investigator MD Paide 72713 ESTONIA Vee Perearstikeskus Vee 6 233004 Paju Külli Sub-Investigator/Co-Investigator MD Paide 72713 ESTONIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Groupe Hospitalier Les Portes du Sud 2 Avenue du 11 Novembre 1918 250001 Bully Chantal Sub-Investigator/Co-Investigator MD Venissieux 69200 FRANCE Groupe Hospitalier Les Portes du Sud 2 Avenue du 11 Novembre 1918 250001 Decaudain Aurélie Sub-Investigator/Co-Investigator MD Venissieux 69200 FRANCE Groupe Hospitalier Les Portes du Sud 2 Avenue du 11 Novembre 1918 250001 Dureau Drevard Elisabeth Sub-Investigator/Co-Investigator MD Venissieux 69200 FRANCE Groupe HospitalierLes Portes du Sud 2 Avenue du 11 Novembre 1918 250001 Serusclat~xr46i Pierre Principal Investigator MD Venissieux 69200 FRANCE Centre Hospitalier Saint Louis Service D'Endocrinologie Et Diabetologie Rue Du Dr A.schweitzer 250002 Bernardin Marc Sub-Investigator/Co-Investigator MD La Rochelle Cedex 17019 FRANCE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centre Hospitalier Saint Louis Service D'Endocrinologie Et Diabetologie Rue Du Dr A.schweitzer 250002 Principal Investigator MD Gouet~xr47i Didier La Rochelle Cedex 17019 FRANCE Centre Hospitalier Lyon Sud Service Endocrinologie-Diabétologie – Pavillon médical – 165 Chemin du Grand Revoyet 250003 Disse Emmanuel Sub-Investigator/Co-Investigator MD Pierre Benite 69310 FRANCE Centre Hospitalier Lyon Sud Service Endocrinologie-Diabétologie – Pavillon médical – 165 Chemin du Grand Revoyet 250003 Principal Investigator MD, PhD Laville~xr48 iMartine Pierre Benite 69310 FRANCE Centre Hospitalier Lyon Sud Service Endocrinologie-Diabétologie – Pavillon médical – 165 Chemin du Grand Revoyet 250003 Vouillarmet Julien Sub-Investigator/Co-Investigator MD Pierre Benite 69310 FRANCE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) CH de Corbeil Service Endocrinologie-diabétologie 116 bd Jean- Jaurès 250006 Principal Investigator MD Charpentier~xr49i Guillaume Corbeil Essonnes Cedex 91106 FRANCE CH de Corbeil Service Endocrinologie-diabétologie 116 bd Jean- Jaurès 250006 Petit Catherine Sub-Investigator/Co-Investigator MD Corbeil Essonnes cedex 91106 FRANCE Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Ganz Xenia Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Principal Investigator PhD,MD Hanefeld~xr50i Markolf Fiedlerstraße 34 Dresden 01307 GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Henkel Elena Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 John Franziska Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Müssig Ilona Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Pistrosch Frank Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY Gesellschaft für Wissens- und Technologietransfer mbH (GWT-TUD GmbH) Zentrum für Klinische Studien Forschungsbereich Endokrinologie/Stoffwechsel 276001 Pohl Wilgard Sub-Investigator/Co-Investigator MD Fiedlerstraße 34 Dresden 01307 GERMANY Diabetologische Gemeinschaftspraxis Parkstraße 26 Neumünster 276002 Principal Investigator MD Bockmann~xr51i Gerd-Uwe 24534 Schlewig-Holstein GERMANY Diabetologische Gemeinschaftspraxis Parkstraße 26 Neumünster 276002 Jacobs Birgit Sub-Investigator/Co-Investigator MD 24534 Schlewig-Holstein GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetologische Gemeinschaftspraxis Parkstraße 26 Neumünster 276002 Molkewehrum Maren Sub-Investigator/Co-Investigator MD 24534 Schlewig-Holstein GERMANY Klinische Forschung Berlin-Buch GmbH Haus 85D Robert-Rössle-Straße 10 276003 Djacenko Svetlana Sub-Investigator/Co-Investigator MD Berlin 13125 GERMANY Klinische Forschung Berlin-Buch GmbH Haus 85D Robert-Rössle-Straße 10 276003 Principal Investigator MD Khariouzov~xr52i Andrei Berlin 13125 GERMANY Klinische Forschung Berlin-Buch GmbH Haus 85D Robert-Rössle-Straße 10 276003 Züchner Dirk Sub-Investigator/Co-Investigator MD Berlin 13125 GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetische Schwerpunktpraxis Kampstraße 45 Nordrhein-Westfalen 276004 Principal Investigator MD Busch~xr53 iKlaus Dortmund 44137 GERMANY Diabetische Schwerpunktpraxis Kampstraße 45 Nordrhein-Westfalen 276004 Von Der Ecken Bernhard Sub-Investigator/Co-Investigator MD Dortmund 44137 GERMANY Institut für klinische Forschung und Entwicklung Berlin GmbH Große Hamburger Straße 5-11 276005 Principal Investigator MD Derwahl~xr54i Karl Michael Berlin 10115 GERMANY Institut für klinische Forschung und Entwicklung Berlin GmbH Große Hamburger Straße 5-11 276005 Kleinhardt Martina Sub-Investigator/Co-Investigator MD Berlin 10115 GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Institut für klinische Forschung und Entwicklung Berlin GmbH Große Hamburger Straße 5-11 276005 Nicula Diana Sub-Investigator/Co-Investigator MD Berlin 10115 GERMANY Klinische Forschung Hamburg GmbH Hoheluftchaussee 18 276006 Hahn~xr55 Michaeli Principal Investigator MD Hamburg 20253 GERMANY kKlinische Forschung Hamburg GmbH Hoheluftchaussee 18 276006 Peldschus~xr56i Meike Principal Investigator MD Hamburg 20253 GERMANY Klinische Forschung Hamburg GmbH Hoheluftchaussee 18 276006 Peldschus Meike Sub-Investigator/Co-Investigator MD Hamburg 20253 GERMANY Klinische Forschung Hamburg GmbH Hoheluftchaussee 18 276006 Thron Andrea Sub-Investigator/Co-Investigator MD Hamburg 20253 GERMANY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Klinische Forschung Dresden GmbH Prager Straße 10 276007 Günzel Andrea Sub-Investigator/Co-Investigator MD Dresden 01069 GERMANY Klinische Forschung Dresden GmbH Prager Straße 10 276007 Heymer~xr57i Peter Principal Investigator MD Dresden 01069 GERMANY Klinische Forschung Dresden GmbH Prager Straße 10 276007 Winkler Jan Sub-Investigator/Co-Investigator MD Dresden 01069 GERMANY Zala Megyei Kórház Belgyógyászati, Zrínyi u. 1. 348001 Bagosi Zoltán Sub-Investigator/Co-Investigator MD Zalaegerszeg 8900 HUNGARY Zala Megyei Kórház Belgyógyászati, Zrínyi u. 1. 348001 Bujtor Zoltán Sub-Investigator/Co-Investigator MD Zalaegerszeg 8900 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Zala Megyei Kórház Belgyógyászati, Zrínyi u. 1. 348001 Oroszlan~xr58i Tamas Principal Investigator MD Zalaegerszeg 8900 HUNGARY Szőcs Depot Egészségügyi Szolgáltató Kft. József Attila u. 52. I/5. 348002 Adorjáni Endre Sub-Investigator/Co-Investigator MD Budapest 1042 HUNGARY Szőcs Depot Egészségügyi Szolgáltató Kft. József Attila u. 52. I/5. 348002 Szocs~xr59 iAlbert Principal Investigator MD Budapest 1042 HUNGARY DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Bezzegh Katalin Sub-Investigator/Co-Investigator MD Balatonfüred 8230 HUNGARY DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Buday Barbara Sub-Investigator/Co-Investigator MD Balatonfüred 8230 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Kemény Vendel Sub-Investigator/Co-Investigator MD Balatonfüred 8230 HUNGARY DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Kulcsár Enikõ Sub-Investigator/Co-Investigator MD Balatonfüred 8230 HUNGARY DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Literáti-Nagy Botond Sub-Investigator/Co-Investigator MD Balatonfüred 8230 HUNGARY DRC Gyógyszervizsgáló Központ Kft. Ady Endre u. 12. 348003 Peterfai~xr60i Eva Principal Investigator MD Balatonfüred 8230 HUNGARY Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Ábrahám György Sub-Investigator/Co-Investigator MD, PhD Szeged 6720 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Principal Investigator MD Lengyel~xr61i Csaba Szeged 6720 HUNGARY Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Palotás Zoltán Sub-Investigator/Co-Investigator MD Szeged 6720 HUNGARY Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Takács Róbert Sub-Investigator/Co-Investigator MD Szeged 6720 HUNGARY Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Várkonyi Tamás Sub-Investigator/Co-Investigator MD Szeged 6720 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ÁOK I. sz. Belgyógyászati Klinika, Korányi fasor 8-10. 348004 Witttmann Tibor Sub-Investigator/Co-Investigator PhD,MD Szeged 6720 HUNGARY Egyesitett Szent Istvan es Szent Laszlo Korhaz- Rendelõintézet, II. Belgyogyaszat Nagyvarad ter 1. C. epulet 348006 Kerekes Mate Sandor Sub-Investigator/Co-Investigator MD Budapest 1097 HUNGARY Egyesitett Szent Istvan es Szent Laszlo Korhaz- Rendelõintézet, II. Belgyogyaszat Nagyvarad ter 1. C. epulet 348006 Szasz Mate Zsolt Sub-Investigator/Co-Investigator MD Budapest 1097 HUNGARY Egyesitett Szent Istvan es Szent Laszlo Korhaz- Rendelõintézet, II. Belgyogyaszat Nagyvarad ter 1. C. epulet 348006 Principal Investigator MD, PhD Voros~xr62i Peter Budapest 1097 HUNGARY Qualiclinic Kft. Dereglye u 5/B 1. em. 3. 348007 Kis~xr Janos63i Principal Investigator MD Budapest 1036 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Qualiclinic Kft. Dereglye u 5/B 1. em. 3. 348007 Kiss Zsófia Sub-Investigator/Co-Investigator MD Budapest 1036 HUNGARY Kanizsai Dorottya Kórház Belgyógyászati Osztály, Szekeres J. u. 2-8. 348008 Bálint Tünde Sub-Investigator/Co-Investigator MD Nagykanizsa 8800 HUNGARY Kanizsai Dorottya Kórház Belgyógyászati Osztály, Szekeres J. u. 2-8. 348008 Kesmarki~xr64i Nora Principal Investigator MD Nagykanizsa 8800 HUNGARY Fejér Megyei Szent György Egyetemi Oktató Kórház Seregélyesi út 3 348010 Principal Investigator MD Balsay~xr65i Miklos Székesfehérvár 8000 HUNGARY Fejér Megyei Szent György Egyetemi Oktató Kórház Seregélyesi út 3 348010 Tóth László Sub-Investigator/Co-Investigator MD Székesfehérvár 8000 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Selye János Kórház Belgyógyászati Szakrendelés, Diabetológiai Szakambulancia 348011 Revesz~xr66i Katalin Principal Investigator MD Beöthy Zs. u. 4. Komárom 2900 HUNGARY Selye János Kórház Belgyógyászati Szakrendelés, Diabetológiai Szakambulancia 348011 Schlezák Judit Sub-Investigator/Co-Investigator MD Beöthy Zs. u. 4. Komárom 2900 HUNGARY Dental-Med Co. Bt. Mártírok útja 9. 348012 Benke Károly Sub-Investigator/Co-Investigator MD Sátoraljaújhely 3980 HUNGARY Dental-Med Co. Bt. Mártírok útja 9. 348012 Ples~xr6 Zsolt7i Principal Investigator MD Sátoraljaújhely 3980 HUNGARY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Crippa Valentina Giulia Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Magistro Andrea Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY U.O. Medicina Generale Indirizzo Diabetologico Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Monti Lucilla Domenica Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Perticone FRANCEsca Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Principal Investigator MD Piatti~xr68 Piermarcoi Milan 20132 Milan ITALY Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Rossi Margherita Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Unità Operativa di Medicina Generale a Indirizzo Diabetologico ed Endocrino-Metabolico Ospedale San Raffaele Via Olgettina, 60 380001 Villa Valentina Sub-Investigator/Co-Investigator MD Milan 20132 Milan ITALY U. O. Malattie del Metabolismo e Dietetica Clinica- Padiglione 7 A.O.U. S. Orsola Malpighi 380002 Brodosi Lucia Sub-Investigator/Co-Investigator MD Via Massarenti, 9 40138 Bologna ITALY U. O. Malattie del Metabolismo e Dietetica Clinica- Padiglione 7 A.O.U. S. Orsola Malpighi 380002 Forlani Gabriele Sub-Investigator/Co-Investigator MD Via Massarenti, 9 40138 Bologna ITALY U. O. Malattie del Metabolismo e Dietetica Clinica- Padiglione 7 A.O.U. S. Orsola Malpighi 380002 Marchesini~xr69i Reggiani Giulio Principal Investigator PhD, MD Via Massarenti, 9 40138 Bologna ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) U. O. Malattie del Metabolismo e Dietetica Clinica- Padiglione 7 A.O.U. S. Orsola Malpighi 380002 Sasdelli Anna Simona Sub-Investigator/Co-Investigator MD Via Massarenti, 9 40138 Bologna ITALY Sezione Scientifica di Diabetologia e Metabolismo – Edificio 3 Seconda Universitá di Napoli – II Policlinico 380003 Gentile~xr70i Sandro Principal Investigator PhD, MD via Pansini, 5 Napoli 80131 ITALY Sezione Scientifica di Diabetologia e Metabolismo – Edificio 3 Seconda Universitá di Napoli – II Policlinico 380003 Carbone Lucia Sub-Investigator/Co-Investigator MD via Pansini, 5 Napoli 80131 ITALY Sezione Scientifica di Diabetologia e Metabolismo – Edificio 3 Seconda Universitá di Napoli – II Policlinico 380003 Guarino Giuseppina Sub-Investigator/Co-Investigator MD via Pansini, 5 Napoli 80131 ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s)

U. O. C. Medicina Interna Centro di Riferimento Diabete tipo 2 Policlinico Tor Vergata 380005 Galli Angelica Sub-Investigator/Co-Investigator MD Viale Oxford, 81 Roma 00133 Roma ITALY U. O. C. Medicina Interna Centro di Riferimento Diabete tipo 2 Policlinico Tor VergataViale Oxford, 81 380005 Lauro~xr71i Davide Principal Investigator PhD,MD Roma 00133 Roma ITALY U. O. C. Medicina Interna Centro di Riferimento Diabete tipo 2 Policlinico Tor Vergata Viale Oxford, 81 380005 Rinaldi Maria Elena Sub-Investigator/Co-Investigator MD Roma 00133 Roma ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Andreozzi Francesco Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Caglioti Chiara Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Loprete Antonio Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Mastroianni Simona Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Arturi Franco Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Succurro Elena Sub-Investigator/Co-Investigator MD 88100 Catanzaro ITALY Università Magna Graecia Policlinico Univ. Germaneto Viale Europa, Loc. Germaneto 380006 Principal Investigator PhD,MD Sesti~xr72i Giorgio 88100 Catanzaro ITALY Riga Region Hospital, Outpatient Clinic Ziedu Street 5 428001 Helda~xr73 Renatei Principal Investigator MD Sigulda LV-2150 LATVIA Riga Region Hospital, Outpatient Clinic Ziedu Street 5 428001 Kampina Elga Sub-Investigator/Co-Investigator MD Sigulda LV-2150 LATVIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) LUMPII Medical Practice A. Caka Street 50 428002 Balcere Inga Sub-Investigator/Co-Investigator MD Riga LV-1011 LATVIA LUMPII Medical Practice A. Caka Street 50 428002 Ducena~xr74i Kristine Principal Investigator MD Riga LV-1011 LATVIA SIA Adoria A.Caka Street 70-3 428003 Busmane~xr75i Arija Principal Investigator MD Riga LV-1011 LATVIA SIA Adoria A.Caka Street 70-3 428003 Romanova Janina Sub-Investigator/Co-Investigator MD Riga LV-1011 LATVIA SIA Adoria A.Caka Street 70-3 428003 Romanova Margarita Sub-Investigator/Co-Investigator MD Riga LV-1011 LATVIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) SIA Adoria A.Caka Street 70-3 428003 Rudzïte Evija Sub-Investigator/Co-Investigator MD Riga LV-1011 LATVIA SIA Diabetes Center Riepnieku Street 2 428004 Broka Santa Sub-Investigator/Co-Investigator MD Riga LV-1050 LATVIA SIA Diabetes Center Riepnieku Street 2 428004 Stelmane~xr76i Indra Principal Investigator MD Riga LV-1050 LATVIA Center for Clinical and Basic Research Smelio str. 20 440001 Ivanauskiene Regina Sub-Investigator/Co-Investigator MD Vilnius LT-10323 LITHUANIA Center for Clinical and Basic Research Smelio str. 20 440001 Motiejuniene Elona Lilit Sub-Investigator/Co-Investigator MD Vilnius LT-10323 LITHUANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Center for Clinical and Basic Research Smelio str. 20 440001 Visockiene~xr77i Zydrune Principal Investigator PhD, MD Vilnius LT-10323 LITHUANIA Saules Family Medicine Center Partizanu str. 27D 440002 Barsiene Lina Sub-Investigator/Co-Investigator MD,PhD Kaunas LT-49449 LITHUANIA Saules Family Medicine Center Partizanu str. 27D 440002 Garsviene Nijole Sub-Investigator/Co-Investigator MD Kaunas LT-49449 LITHUANIA Saules Family Medicine Center Partizanu str. 27D 440002 Kaupiene Jugeta Sub-Investigator/Co-Investigator MD Kaunas LT-49449 LITHUANIA Saules Family Medicine Center Partizanu str. 27D 440002 Urbonas~xr78i Gediminas Principal Investigator PhD,MD Kaunas LT-49449 LITHUANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) JSC "Kristavita" Vaiciuno str. 15/Vyciu str. 2 440003 Baltramonaitiene~xr79i Kristina Principal Investigator MD, PhD Jonava LT-55201 LITHUANIA JSC "Kristavita" Vaiciuno str. 15/Vyciu str. 2 440003 Martinoniene Neringa Sub-Investigator/Co-Investigator MD Jonava LT-55201 LITHUANIA Kedainiai hospital Outpatient clinic Budrio str. 5 440004 Dauksiene Dalia Sub-Investigator/Co-Investigator PhD,MD Kedainiai LT-57164 LITHUANIA Kedainiai hospital Outpatient clinic Budrio str. 5 440004 Zilaitiene~xr80i Birute Principal Investigator MD,PhD Kedainiai LT-57164 LITHUANIA Utena hospital Aukstakalnio str. 3 440005 Griskeviciene Violeta Sub-Investigator/Co-Investigator MD Utena LT-28151 LITHUANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Utena hospital Aukstakalnio str. 3 440005 Velaviciene~xr81i Audrone Principal Investigator MD Utena LT-28151 LITHUANIA JSC Mano Gydytojas Nemuno str. 75-230 440006 Kakariekiene~xr82i Vaida Principal Investigator MD Panevezys LT-37355 LITHUANIA Hospital of LITHUANIAn University of Health Sciences Eiveniu str. 2 440007 Jakuboniene Neli Sub-Investigator/Co-Investigator MD Kaunas LT-50009 LITHUANIA Hospital of LITHUANIAn University of Health Sciences Eiveniu str. 2 440007 Kriksciuniene Ruta Sub-Investigator/Co-Investigator MD Kaunas LT-50009 LITHUANIA Hospital of LITHUANIAn University of Health Sciences Eiveniu str. 2 440007 Principal Investigator MD Lasiene~xr83i Jurate Kaunas LT-50009 LITHUANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Instituto de Diabetes, Obesidad y Nutricion S.C. Calle 5 de Mayo No. 400 Col. El Empleado 484001 Baez Campos Aurelia Sub-Investigator/Co-Investigator MD Cuernavaca 62250 Morelos MEXICO Instituto de Diabetes, Obesidad y Nutricion S.C. Calle 5 de Mayo No. 400 Col. El Empleado 484001 Peralta Cantú Irving Alain Sub-Investigator/Co-Investigator MD Cuernavaca 62250 Morelos MEXICO Instituto de Diabetes, Obesidad y Nutricion S.C. Calle 5 de Mayo No. 400 Col. El Empleado 484001 Sánchez Vargas Pedro Rafael Sub-Investigator/Co-Investigator MD Cuernavaca 62250 Morelos MEXICO Instituto de Diabetes, Obesidad y Nutrición S.C. Calle 5 de Mayo No. 400 Col. El Empleado 484001 Sauque~xr84i Reyna Leobardo Principal Investigator MD Cuernavaca 62250 Morelos MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diseño y Planeación en Investigación Medica S.C. Morelos No.2203 Col. Arcos Vallarta Guadalajara 484002 Álvarez-Carrillo Rebeca Sub-Investigator/Co-Investigator MD 44130 Jalisco MEXICO Diseño y Planeación en Investigación Medica S.C. Morelos No. 2203 Col. Arcos Vallarta Guadalajara 484002 Principal Investigator MD Calvo~xr85 Vargasi Cesar 44130 Jalisco MEXICO Diseño y Planeación en Investigación Medica S.C. Morelos No. 2203 Col. Arcos Vallarta Guadalajara 484002 Loredo-Padrón Imelda Sub-Investigator/Co-Investigator MD 44130 Jalisco MEXICO Diseño y Planeación en Investigación Medica S.C. Morelos No. 2203 Col. Arcos Vallarta Guadalajara 484002 Ramírez-Pompa María del Carmen Sub-Investigator/Co-Investigator MD 44130 Jalisco MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diseño y Planeación en Investigación Medica S.C. Morelos No. 2203 Col. Arcos Vallarta Guadalajara 484002 Vera-Bocanegra Alejandro Sub-Investigator/Co-Investigator MD 44130 Jalisco MEXICO Consultorio Privado Av. Salto del Agua No. 2154 L-4 Col. Jardines del Country 484004 Aguilar~xr86i Orozco Raul Principal Investigator MD Guadalajara 44210 Jalisco MEXICO Consultorio Privado Av. Salto del Agua No. 2154 L-4 Col. Jardines del Country 484004 Vargas-Flores Armando Rafael Sub-Investigator/Co-Investigator MD Guadalajara 44210 Jalisco MEXICO Fundación Cardiovascular de Aguascalientes. A.C. República del Perú No. 202 Fraccionamiento Las Américas 484005 Principal Investigator MD Bayram~xr87i Llamas Edmundo 20230 Aguascalientes Aguascalientes MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Fundación Cardiovascular de Aguascalientes A.C. República del Perú No. 202 Fraccionamiento Las Americas 484005 Juárez-Cervantes María del Cármen Sub-Investigator/Co-Investigator MD 20230 Aguascalientes Aguascalientes MEXICO Fundación Cardiovascular de Aguascalientes A.C. República del Perú No. 202 Fraccionamiento Las Americas 484005 Marín-López José de Jesús Sub-Investigator/Co-Investigator MD 20230 Aguascalientes Aguascalientes MEXICO Fundación Cardiovascular de Aguascalientes A.C. República del Perú No. 202 Fraccionamiento Las Americas 484005 Pacheco-Aranda Elizabeth Noemi Sub-Investigator/Co-Investigator MD 20230 Aguascalientes Aguascalientes MEXICO Hospital Universitario "José Eleuterio González" Madero Y Gonzalitos S / N Col. Mitras Centro 484006 Garza-Félix Sandra Sub-Investigator/Co-Investigator MD Monterrey 64460 Nuevo León MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Universitario "José Eleuterio González" Madero Y Gonzalitos S / N Col. Mitras Centro 484006 Gonzalez~xr88i Gonzalez Jose Principal Investigator MD Monterrey 64460 Nuevo León MEXICO Hospital Universitario "José Eleuterio González" Madero Y Gonzalitos S / N Col. Mitras Centro 484006 Sánchez-Garza Liliana Sub-Investigator/Co-Investigator MD Monterrey 64460 Nuevo León MEXICO Hospital Universitario "José Eleuterio González" Madero Y Gonzalitos S / N Col. Mitras Centro 484006 Zanabria Alvarado César Alejandro Sub-Investigator/Co-Investigator MD Monterrey 64460 Nuevo León MEXICO IMED Internal Medicine Clin Trials Padua No. 654 Fraccionamiento Gonzalitos 484007 Garza~xr89 iRuiz Jose Principal Investigator MD Nuevo León 64020 Monterrey MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) IMED Internal Medicine Clin Trials Padua No. 654 Fraccionamiento Gonzalitos 484007 Recio-Figueroa Carlos Fernando Sub-Investigator/Co-Investigator MD Nuevo León 64020 Monterrey MEXICO IMED Internal Medicine Clin Trials Padua No. 654 Fraccionamiento Gonzalitos 484007 Anaya-Cantú Samuel Sub-Investigator/Co-Investigator MD Nuevo León 64020 Monterrey MEXICO IMED Internal Medicine Clin Trials Padua No. 654 Fraccionamiento Gonzalitos 484007 Garza-Reza José Ángel Sub-Investigator/Co-Investigator MD Nuevo León 64020 Monterrey MEXICO Centro de Investigación Clínica Endocrinológica de Jalisco S.C. Tarascos No. 3469 -505 y 503A Col. Mitras Centro 484009 González-Pérez Rosa María Sub-Investigator/Co-Investigator MD Guadalajara 44670 Jalisco MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centro de Investigación Clínica Endocrinológica de Jalisco S.C. Tarascos No. 3469 -505 y 503A Col. Mitras Centro 484009 Aguilar-Parra Lilia Georgina Sub-Investigator/Co-Investigator MD Guadalajara 44670 Jalisco MEXICO Centro de Investigación Clínica Endocrinológica de Jalisco S.C. Tarascos No. 3469 -505 y 503A 484009 González-Valencia Carlos Miguel Sub-Investigator/Co-Investigator MD Col. Mitras CentroGuadalajara 44670 Jalisco MEXICO Centro de Investigación Clínica Endocrinológica de Jalisco S.C. Tarascos No. 3469 -505 y 503A Col. Mitras Centro 484009 Principal Investigator MD Jimenez~xr90i Ramos Silvia Guadalajara 44670 Jalisco MEXICO

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centro de Investigación Médica de Occidente S.C. Av. Empresarios No. 150Torre Elite Piso 16 Consultorio 1602 484010 Caballero-González Sandra Obdulia Sub-Investigator/Co-Investigator MD Zapopan 45116 Jalisco MEXICO Centro de Investigación Médica de Occidente S. C. Av. Empresarios No. 150 Torre Elite Piso 16 Consultorio 1602 484010 Pelayo~xr91i Susana Principal Investigator MD Zapopan 45116 Jalisco MEXICO Centrum Diabetologiczne, Klinika Chorob Wewnetrznych, Endokrynologii i Diabetologii CSK MSW ul.Woloska 137 616001 Franek Edward Sub-Investigator/Co-Investigator PR Warszawa 02-507 Mazowieckie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Centrum Diabetologiczne ; Klinika Chorob Wewnetrznych, Endokrynologii i Diabetologii CSK MSW ul.Woloska 137 616001 Principal Investigator MD, PhD Jedynasty~xr92i Krystyna Warszawa 02-507 Mazowieckie POLAND Centrum Diabetologiczne, Klinika Chorob Wewnetrznych Endokrynologii i Diabetologii CSK MSW ul.Woloska 137 616001 Turowska Olga Sub-Investigator/Co-Investigator MD, PhD Warszawa 02-507 Mazowieckie POLAND NZOZ Specjalistyczny Osrodek Internistyczno- Diabetologiczny Ul. Zamenhofa 10\20 616002 Arciszewska~xr93i Malgorzata Principal Investigator MD, PhD Bialystok 15-435 Podlaskie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) NZOZ Specjalistyczny Osrodek Internistyczno- Diabetologiczny Ul. Zamenhofa 10\20 616002 Peczynska Jadwiga Sub-Investigator/Co-Investigator MD, PhD Bialystok 15-435 Podlaskie POLAND NZOZ Specjalistyczny Osrodek Internistyczno- Diabetologiczny Ul. Zamenhofa 10\20 616002 Swierszcz Teresa Sub-Investigator/Co-Investigator MD Bialystok 15-435 Podlaskie POLAND Centrum Medyczne AMED ul. Gen. Jozefa Zajaczka 9B \ U1 Warszawa 616003 Dudek Anna Sub-Investigator/Co-Investigator MD, PhD 01-518 Mazowieckie POLAND Centrum Medyczne AMED ul. Gen. Jozefa Zajaczka 9B \U1 Warszawa 616003 Principal Investigator MD Jusiak~xr94i Katarzyna 01-518 Mazowieckie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Elwira Gromniak ul. T. Starzynskiego 2 616004 Gromniak~xr95i Elwira Principal Investigator MD, PhD Szczecin 70-506 Zachodniopomorskie POLAND Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Elwira Gromniak ul. T. Starzynskiego 2 616004 Holda Ewa Sub-Investigator/Co-Investigator MD Szczecin 70-506 Zachodniopomorskie POLAND Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Elwira Gromniak ul. T. Starzynskiego 2 616004 Wolny Malgorzata Sub-Investigator/Co-Investigator MD, PhD Szczecin 70-506 Zachodniopomorskie POLAND Medyczne Centrum Diabetologiczno- Endokrynologiczno- Metaboliczne DIAB-ENDO- MET Sp.z o.o. ul. Rusznikarska 17 616005 Mirocka Joanna Sub-Investigator/Co-Investigator MD Krakow 31-261 Malopolskie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medyczne Centrum Diabetologiczno- Endokrynologiczno-Metaboliczne DIAB-ENDO- MET Sp.z o.o. ul. Rusznikarska 17 616005 Plinta Maria Sub-Investigator/Co-Investigator MD Krakow 31-261 Malopolskie POLAND Medyczne Centrum Diabetologiczno- Endokrynologiczno- Metaboliczne DIAB-ENDO- MET Sp.z o.o. ul. Rusznikarska 17 616005 Principal Investigator MD Stankiewicz~xr96i Andrzej Krakow 31-261 Malopolskie POLAND Medyczne Centrum Diabetologiczno- Endokrynologiczno- Metaboliczne DIAB-ENDO- MET Sp.z o.o. ul. Rusznikarska 17 616005 Zuradzka-Wajda Dorota Sub-Investigator/Co-Investigator MD Krakow 31-261 Malopolskie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) NZOZ Osrodek Leczenia Schorzen Cywilizacyjnych, Zespol Poradni Specjalistycznych Aleja Pokoju 4 616006 Cieslik~xr97i Grazyna Principal Investigator MD, PhD Krakow 31-548 Malopolskie POLAND NZOZ Osrodek Leczenia Schorzen Cywilizacyjnych Zespol Poradni Specjalistycznych Aleja Pokoju 4 616006 Cieslik Karolina Sub-Investigator/Co-Investigator MD Krakow 31-548 Malopolskie POLAND NZOZ Mediab Sp. Z o.o.; Centrum Diabetologii ul. Wyszynskiego 61 Lodz 616007 Jozefowska Malgorzata Sub-Investigator/Co-Investigator MD, PhD 94-074 Lodzkie POLAND NZOZ Mediab Sp. Z o.o.; Centrum Diabetologii ul. Wyszynskiego 61 Lodz 616007 Lipinska Agnieszka Sub-Investigator/Co-Investigator MD 94-074 Lodzkie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) NZOZ Mediab Sp. Z o.o.; Centrum Diabetologii uul. Wyszynskiego 61 Lodz 616007 Principal Investigator MD, PhD Mikolajczyk-Swatko~xr98i Anna 94-074 Lodzkie POLAND NZOZ Med-Art; Poradnie Specjalistyczne Os. Ks.Wladyslawa 27 Zory 616008 Gawel Wladyslaw Sub-Investigator/Co-Investigator MD 44-240 Slaskie POLAND NZOZ Med-Art; Poradnie Specjalistyczne Os. Ks.Wladyslawa 27 Zory 616008 Karasek Dariusz Sub-Investigator/Co-Investigator MD 44-240 Slaskie POLAND NZOZ Med-Art; Poradnie Specjalistyczne Os. Ks.Wladyslawa 27 Zory 616008 Principal Investigator MD, PhD Szostek-Gawel~xr99i Violetta 44-240 Slaskie POLAND

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) SC MEDIAB SRL 8A Prof. Dr. Gheorghe Marinescu street, AP I-II Targu Mures 642001 Principal Investigator MD Cif~xr1 Adriana00i 540142 Targu Mures ROMANIA SC MEDIAB SRL 8A Prof. Dr. Gheorghe Marinescu street, AP I-II Targu Mures 642001 Suciu Elena Mirela Sub-Investigator/Co-Investigator MD 540142 Targu Mures ROMANIA SC MEDIAB SRL 8A Prof. Dr. Gheorghe Marinescu , street, AP I-II Targu Mures 642001 Vicsi Ildiko Sub-Investigator/Co-Investigator MD 540142 Targu Mures ROMANIA Pelican impex SRL 2 C. Coposu Street 410469 642002 Principal Investigator MD Onaca~xr10 1iAdriana Oradea Bihor ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Pelican impex SRL 2 C. Coposu Street, 410469 642002 Onaca Mircea Sub-Investigator/Co-Investigator MD Oradea Bihor ROMANIA Medical Office 'Dr Negrisanu'' 7 Transilvania, , Building A25, entrance A, Ap.3 642003 Geru Polina Sub-Investigator/Co-Investigator MD Timisoara 300456 ROMANIA Medical Office ''Dr Negrisanu'' 7 Transilvania street, Building A25, entrance A, Ap.3 642003 Moica Andreea Sub-Investigator/Co-Investigator MD Timisoara 300456 ROMANIA Medical office 'Ddr Negrisanu'' 7 Transilvania, , Building A25, entrance A. Ap.3 642003 Negrisanu~xr102i Gabriela Principal Investigator MD Timisoara 300456 ROMANIA Medical Office ''dr Negrisanu'' 7 Transilvania, , Building A25, entrance A, Ap.3 642003 Viruzab Maria Mihaela Sub-Investigator/Co-Investigator MD Timisoara 300456 ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medical centre “ Sfantul. Stefan” 9 Samuil Micu street Timisoara 642004 Ionutiu Lavinia Sub-Investigator/Co-Investigator MD 300125 Timisoara ROMANIA Medical centre “ Sfantul. Stefan” 9 Samuil Micu street Timisoara 642004 Principal Investigator MD, PhD Munteanu~xr103i Mircea 300125 Timisoara ROMANIA Medical centre “ Sfantul. Stefan” 9 Samuil Micu street Timisoara 642004 Sabo Patricia Sub-Investigator/Co-Investigator MD 300125 Timisoara ROMANIA Consultmed Medical Center 70 Pacurarilor Street bl. 550, ground floor 642005 Busuioc-Witowschi Dan Sub-Investigator/Co-Investigator MD Iasi 700547 ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Consultmed Medical Center 70 Pacurarilor Street bl. 550, ground floor 642005 Nistor Laura Iulia Sub-Investigator/Co-Investigator MD Iasi 700547 ROMANIA Consultmed Medical Center 70 Pacurarilor Street bl. 550, ground floor 642005 Principal Investigator MD Pintilei~xr10 4iElla Iasi 700547 ROMANIA Consultmed Medical Center 70 Pacurarilor Street bl. 550, ground floor 642005 Reurean Pintilei Delia Viola Sub-Investigator/Co-Investigator MD Iasi 700547 ROMANIA Municipality Hospital "Dr.Alexendru Simionescu" 14 Victoriei street Hunedoara 642006 Principal Investigator MD Pavel~xr105 Mioarai 331057 Hunedoara ROMANIA Municipality Hospital "Dr.Alexendru Simionescu" 14 Victoriei street 642006 Radu Irina Sub-Investigator/Co-Investigator MD Hunedoara 331057 ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) "Prof. Dr. N.C. Paulescu", National Institute of Diabetes Nutrition and Metabolic Diseases 12 I.L. Caragiale Street, District 2 642007 Caceaune~xr106i Elena Principal Investigator MD Bucharest 020475 Bucharest ROMANIA " Prof. Dr. N.C. Paulescu", National Institute of Diabetes Nutrition and Metabolic Diseases 12 I.L. Caragiale Street, District 2 Bucharest 642007 Simionescu Cleo Sub-Investigator/Co-Investigator MD 020475 Bucharest ROMANIA “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Constantin Ciprian Sub-Investigator/Co-Investigator MD Bucharest 010825 Bucharest ROMANIA “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Constantin Georgiana Sub-Investigator/Co-Investigator MD Bucharest 010825 Bucharest ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Ivan Sanda Sub-Investigator/Co-Investigator MD Bucharest 010825 Bucharest ROMANIA “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Mazilu Adina Sub-Investigator/Co-Investigator MD Bucharest 010825 Bucharest ROMANIA “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Ranetti~xr107i Aurelian Principal Investigator MD Bucharest 010825 Bucharest ROMANIA “Dr. Carol Davila" Central University Emergency Military . Hospital 88 Vulcanescu Street, District 1 642008 Sburlis Marinela Sub-Investigator/Co-Investigator MD Bucharest 010825 Bucharest ROMANIA

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400006 Cluj-Napoca ROMANIA County Clinical Hospital Cluj- Napoca- Clinical Centre of Diabetes Nutrition and Metabolic Diseases 3-5 Clinicilor street 642009 Principal Investigator MD Cerghizan~xr108i Anca Cluj-Napoca 400006 Cluj-Napoca ROMANIA County Clinical Hospital Cluj- Napoca- Clinical Centre of Diabetes Nutrition and Metabolic Diseases3-5 Clinicilor street 642009 Copcea Ilinca Sub-Investigator/Co-Investigator MD Cluj Napoca 400006 Cluj-Napoca ROMANIA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) County Clinical Hospital Cluj- Napoca- Clinical Centre of Diabetes Nutrition and Metabolic Diseases3-5 Clinicilor street 642009 Roman Gabriela Sub-Investigator/Co-Investigator MD Cluj Napoca 400006 Cluj-Napoca ROMANIA 1st Clinic of Therapy of Postgraduate of Physicians n.a.Molc Ruzovskaya str,12 643001 Balyasnikova Ekaterina Sub-Investigator/Co-Investigator MD Saint-Petersburg 190013 RUSSIAN FEDERATION 1st Clinic of Therapy of Postgraduate of Physicians n.a.Molc Ruzovskaya str.,12 643001 Romashevskiy Boris Sub-Investigator/Co-Investigator MD, PhD Saint-Petersburg 190013 RUSSIAN FEDERATION 1st Clinic of Therapy of Postgraduate of Physicians n.a.Molc Ruzovskaya str.,12 643001 Principal Investigator MD, PhD Shustov~xr109i Sergey Saint-Petersburg 190013 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) St Elizabeth City Hospital 14, Vavilovykh Str. 643002 Galakhova Ravilya Sub-Investigator/Co-Investigator MD, PhD St-Petersburg 195257 RUSSIAN FEDERATION St Elizabeth City Hospital 14, Vavilovykh Str. 643002 Makarova Anna Sub-Investigator/Co-Investigator MD St-Petersburg 195257 RUSSIAN FEDERATION St Elizabeth City Hospital 14, Vavilovykh Str. 643002 Serebryakova Inna Sub-Investigator/Co-Investigator MD St-Petersburg 195257 RUSSIAN FEDERATION St Elizabeth City Hospital 14, Vavilovykh Str. 643002 Vorokhobina~xr110i Natalia Principal Investigator MD, PhD St-Petersburg 195257 RUSSIAN FEDERATION Municipal Multispecialty Outpatient clinic #117 5/1, Simonova str. 643003 Alpenidze~xr111i Diana Principal Investigator MD, PhD St. Petersburg 194358 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Municipal Multispecialty Outpatient clinic #117 5/1, Simonova str. 643003 Kondratieva Natalia Sub-Investigator/Co-Investigator MD St. Petersburg 194358 RUSSIAN FEDERATION Municipal Multispecialty Outpatient clinic #117 5/1, Simonova str. 643003 Martjanova Maria Sub-Investigator/Co-Investigator MD St. Petersburg 194358 RUSSIAN FEDERATION Municipal Multispecialty Outpatient clinic #117 5/1, Simonova str. 643003 Nikitina Svetlana Sub-Investigator/Co-Investigator MD St. Petersburg 194358 RUSSIAN FEDERATION Municipal Multispecialty Outpatient clinic #117 5/1, Simonova str. 643003 Otroshchenko Olga Sub-Investigator/Co-Investigator MD St. Petersburg 194358 RUSSIAN FEDERATION Voronezh Regional Clinical Diagnostic Centre Lenina Sq., 5a 643004 Glotova Natalia Sub-Investigator/Co-Investigator MD Voronezh 394018 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Voronezh Regional Clinical Diagnostic Centre Lenina Sq., 5a 643004 Kolimbet Larisa Sub-Investigator/Co-Investigator MD Voronezh 394018 RUSSIAN FEDERATION Voronezh Regional Clinical Diagnostic Centre Lenina Sq., 5a 643004 Zhdanova~xr112i Elena Principal Investigator PhD, MD Voronezh 394018 RUSSIAN FEDERATION Saint-Peterburg State Budgetary Health Institution City multi-field hospital N°2 5, Uchebny per. 643005 Bessonova Elena Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION Saint-Peterburg State Budgetary Health Institution City multi-field hospital N°2 5, Uchebny per. 643005 Mukhamedyanova Elena Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION Saint-Peterburg State Budgetary Health Institution City multi-field hospital N°2 5, Uchebny per. 643005 Orlova Valeria Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Saint-Peterburg State Budgetary Health Institution City multi-field hospital N°2 5, Uchebny per. 643005 Zaitseva Ludmila Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION Saint-Peterburg State Budgetary Health Institution City multi-field hospital N°2 5, Uchebny per. 643005 Principal Investigator MD, PhD Zalevskaya~xr113i Alsu St-Petersburg 194354 RUSSIAN FEDERATION City Hospital N°67 Salama Adilya str, 2 643006 Goncharova Ekaterina Sub-Investigator/Co-Investigator MD 123154 Moscow RUSSIAN FEDERATION City Hospital N°67 Salama Adilya str, 2 643006 Petunina~xr114i Nina Principal Investigator MD 123154 Moscow RUSSIAN FEDERATION City Hospital N°67 Salama Adilya str, 2 643006 Terekhova Anna Sub-Investigator/Co-Investigator MD 123154 Moscow RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) City Consultative-Diagnostic Center #1 10, Sikeirosa Str. 643007 Astamirova Khavra Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION City Consultative-Diagnostic Center #1 10, Sikeirosa Str. 643007 Ignatyeva Anna Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION City Consultative-Diagnostic Center #1 10, Sikeirosa Str. 643007 Karpova~xr115i Irina Principal Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION City Consultative-Diagnostic Center #1 10, Sikeirosa Str. 643007 Khutornaya Oksana Sub-Investigator/Co-Investigator MD St-Petersburg 194354 RUSSIAN FEDERATION Penza Regional Clinical Hospital n.a. N.N. Burdenko 28, Lermontova Str. 643008 Komissarova Ekaterina Sub-Investigator/Co-Investigator MD Penza 440026 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Penza Regional Clinical Hospital n.a. N.N. Burdenko 28, Lermontova Str. 643008 Samylina Irina Sub-Investigator/Co-Investigator MD Penza 440026 RUSSIAN FEDERATION Penza Regional Clinical Hospital n.a. N.N. Burdenko 28, Lermontova Str. 643008 Principal Investigator PhD Sergeeva-Kondrachenko~xr116i Marina Penza 440026 RUSSIAN FEDERATION Penza Regional Clinical Hospital n.a. N.N. Burdenko 28, Lermontova Str. 643008 Shimokhina Olga Sub-Investigator/Co-Investigator MD Penza 440026 RUSSIAN FEDERATION Municipal Clinical Hospital 9 43, Bolshaya Gornaya Str. 643009 Frolova Arina Sub-Investigator/Co-Investigator MD Saratov 410030 RUSSIAN FEDERATION Municipal Clinical Hospital 9 43, Bolshaya Gornaya Str. 643009 Rodionova~xr117i Tatiana Principal Investigator MD Saratov 410030 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Municipal Clinical Hospital 9 43, Bolshaya Gornaya Str. 643009 Znamenshikova Galina Sub-Investigator/Co-Investigator MD Saratov 410030 RUSSIAN FEDERATION Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Gromova Svetlana Sub-Investigator/Co-Investigator MD Saratov 410053 RUSSIAN FEDERATION Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Kunitsyna~xr118i Marina Principal Investigator MD, PhD Saratov 410053 RUSSIAN FEDERATION Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Smirnova Maria Sub-Investigator/Co-Investigator MD Saratov 410053 RUSSIAN FEDERATION Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Vinokurova Valentina Sub-Investigator/Co-Investigator MD Saratov 410053 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Zhukova Elena Sub-Investigator/Co-Investigator MD Saratov 410053 RUSSIAN FEDERATION Regional Clinical Hospital 1, Smirnovskoe uschelie 643011 Potapova Zhanna Sub-Investigator/Co-Investigator MD Saratov 410053 RUSSIAN FEDERATION Republic Hospital n.a. V.A.Baranov Pirogova, 3 643012 Apinenko Ludmila Sub-Investigator/Co-Investigator MD Petrozavodsk 185000 RUSSIAN FEDERATION Republic Hospital n.a. V.A.Baranov Pirogova, 3 643012 Kulagina Tatiana Sub-Investigator/Co-Investigator MD, PhD Petrozavodsk 185000 RUSSIAN FEDERATION Republic Hospital n.a. V.A.Baranov Pirogova, 3 643012 Marusenko Irina Sub-Investigator/Co-Investigator MD, PhD Petrozavodsk 185000 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Republic Hospital n.a. V.A.Baranov Pirogova, 3 643012 Nemchinova Elena Sub-Investigator/Co-Investigator MD Petrozavodsk 185000 RUSSIAN FEDERATION Republic Hospital n.a. V.A.Baranov Pirogova, 3 643012 Vezikova~xr119i Natalia Principal Investigator MD, PhD Petrozavodsk 185000 RUSSIAN FEDERATION Diabetes Center 165, Samarskaya str 643014 Barabanova Natalia Sub-Investigator/Co-Investigator MD Samara 443041 RUSSIAN FEDERATION Diabetes Center 165, Samarskaya str 643014 Skudaev Sergey Sub-Investigator/Co-Investigator MD Samara 443041 RUSSIAN FEDERATION Diabetes Center 165, Samarskaya str 643014 Suldina Tatiana Sub-Investigator/Co-Investigator MD Samara 443041 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes Center 165, Samarskaya str 643014 Verbovaya Maria Sub-Investigator/Co-Investigator MD, PhD Samara 443041 RUSSIAN FEDERATION Diabetes Center 165, Samarskaya str 643014 Verbovaya~xr120i Nelly Principal Investigator MD, PhD Samara 443041 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Charlamova Elena Sub-Investigator/Co-Investigator MD Tomsk 634050 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Latypova Venera Sub-Investigator/Co-Investigator MD Tomsk 634050 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Martynova Irina Sub-Investigator/Co-Investigator MD Tomsk 634050 RUSSIAN FEDERATION

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Siberian State Medical University 2, Moscowsky tract 643016 Oleynik Oxana Sub-Investigator/Co-Investigator MD,PhD Tomsk 634050 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Pavlenko Olga Sub-Investigator/Co-Investigator MD Tomsk 634050 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Samoylova~xr121i Julia Principal Investigator MD,PhD Tomsk 634050 RUSSIAN FEDERATION Siberian State Medical University 2, Moscowsky tract 643016 Soboleva Inna Sub-Investigator/Co-Investigator MD Tomsk 634050 RUSSIAN FEDERATION Helderberg Clinical Trials Centre Sir Lowry's Pass Road Suite 7G & H Arun Place Somerset West Western 710001 Principal Investigator MD Ellis~xr122i Graham Cape 7130 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Helderberg Clinical Trials Centre Sir Lowry's Pass Road Suite 7G & H Arun Place Somerset West Western 710001 Pretorius Catharina Elizabeth Sub-Investigator/Co-Investigator MD Cape 7130 SOUTH AFRICA Helderberg Clinical Trials Centre Sir Lowry's Pass Road Suite 7G & H Arun Place Somerset West Western 710001 Urbach Dorothea Vera Sub-Investigator/Co-Investigator MD Cape 7130 SOUTH AFRICA Helderberg Clinical Trials Centre Sir Lowry's Pass Road Suite 7G & H Arun Place Somerset West Western 710001 Van Der Merwe Maryke Sub-Investigator/Co-Investigator MD Cape 7130 SOUTH AFRICA Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Basson Matthys Sub-Investigator/Co-Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Nel~xr12 Jeanne3i Principal Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Nell Haylene Sub-Investigator/Co-Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Njovane Xolani Sub-Investigator/Co-Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Pretorius Maria Sub-Investigator/Co-Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tiervlei Trial Centre Karl Bremer Hospital Basement Floor 710002 Siebert Mirna Sub-Investigator/Co-Investigator MD Frans Conradie Avenue Bellville 7530 SOUTH AFRICA TREAD Research cc – department of Cardiology Room 41, 8th Floor Tygerburg Hospital Francie van Zijl Drive 710003 Burgess Lesley Jean Sub-Investigator/Co-Investigator PhD Parow Western Cape 7500 SOUTH AFRICA TREAD Research cc- departement of Cardiology Room 41, 8th Floor Tygerburg Hospital Francie van Zijl Drive 710003 Coetzee Kathleen Sub-Investigator/Co-Investigator MD Parow Western Cape 7500 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) TREAD Research cc- department of Cardiology Room 41, 8th Floor Tygerburg Hospital Francie van Zijl Drive 710003 Principal Investigator MD Maritz~xr124i Lize Parow Western Cape 7500 SOUTH AFRICA TREAD Research cc- department of Cardiology Room 41, 8th Floor Tygerburg Hospital Francie van Zijl Drive 710003 Prozesky Hans Walter Sub-Investigator/Co-Investigator MD Parow Western Cape 7500 SOUTH AFRICA Synexus SOUTH AFRICA Stanza Clinical Research Centre 2 Shilovhane Street Mamelodi East 710004 Principal Investigator MD Sebopa~xr125 iBoitumelo Pretoria Gauteng 0122 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Synexus SOUTH AFRICA Stanza Clinical Research Centre 2 Shilovhane Street Mamelodi East 710004 Seopela Vincent Oscar Sub-Investigator/Co-Investigator MD Pretoria Gauteng 0122 SOUTH AFRICA Synexus SOUTH AFRICA Watermeyer Clinical Research Centre 182 Watermeyer Street Meyerspark 710005 Du Toit Margarheta Sub-Investigator/Co-Investigator MD Pretoria Gauteng 0184 SOUTH AFRICA Synexus SOUTH AFRICA Watermeyer Clinical Research Centre 182 Watermeyer Street Meyerspark 710005 Vally Tasneem Sub-Investigator/Co-Investigator MD Pretoria Gauteng 0184 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Synexus SOUTH AFRICA Watermeyer Clinical Research Centre 182 Watermeyer Street Meyerspark 710005 Principal Investigator MD Van~xr12 Nieuwenhuizen6i Elane Pretoria Gauteng 0184 SOUTH AFRICA Synexus SOUTH AFRICA Watermeyer Clinical Research Centre 182 Watermeyer Street Meyerspark 710005 Viljoen Marianne Elizabeth Sub-Investigator/Co-Investigator MD Pretoria Gauteng 0184 SOUTH AFRICA Soweto Clinical Trial Center House 1900 Sycamore Street Dlamini Ext 2 710006 Bhorat~xr127i Asad Principal Investigator MD Soweto Gauteng 1818 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Soweto Clinical Trial Center House 1900 Sycamore Street Dlamini Ext 2 710006 Bhorat Qasim Ebrahim Sub-Investigator/Co-Investigator MD Soweto Gauteng 1818 SOUTH AFRICA Soweto Clinical Trial Center House 1900 Sycamore Street Dlamini Ext 2 710006 Vorajee Haroon Mohamed Sub-Investigator/Co-Investigator MD Soweto Gauteng 1818 SOUTH AFRICA Jedidiah Clinical Trial Centre Room 11, Ground Floor Mercantile Hospital Cnr Durban & Kempston Roads, Korsten 710007 Gani Mashra Sub-Investigator/Co-Investigator MD Port Elizabeth Eastern Cape 6014 SOUTH AFRICA

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Jedidiah Clinical Trial Centre Room 11, Ground Floor Mercantile Hospital Cnr Durban & Kempston Roads, Korsten 710007 Principal Investigator MD Ngcakani~xr128i Nomangesi Port Elizabeth Eastern Cape 6014 SOUTH AFRICA Quart De Poblet Av. de Trafalgar, s/n 1ª Planta / Consulta 8; 724001 Flor Bustos Loida Sub-Investigator/Co-Investigator MD 46930 Valencia SPAIN Quart De Poblet Av. de Trafalgar, s/n 1ª Planta / Consulta 8; 724001 Principal Investigator MD Fraile~xr12 Fraile9i Belen 46930 Valencia SPAIN Hospital Infanta Luisa Unidad de Investigación en Diabetes Servicio de Endocrinologia 724003 García Bidón Héctor Sub-Investigator/Co-Investigator MD C/ San Jacinto, 87 41010 Sevilla SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Infanta Luisa Unidad de Investigación en Diabetes Servicio de Endocrinologia 724003 Rivas~xr130 Fernandezi Margarita Principal Investigator MD C/ San Jacinto, 87 41010 Sevilla SPAIN CAP Hostalets de Balenyà C/ Major, 46 08550 724004 Principal Investigator MD Ballarin~xr131i Angels Hostalets De Balenyà Barcelona SPAIN CAP Hostalets de Balenyà C/ Major, 46 08550 724004 Del Val Nuria Sub-Investigator/Co-Investigator MD Hostalets De Balenyà Barcelona SPAIN Hospital Universitario La Paz Medicina Interna Paseo De La Castellana, 261 724005 Beltrán Romero Luís Matías Sub-Investigator/Co-Investigator MD Madrid 28046 SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Universitario La Paz Medicina Interna Paseo De La Castellana, 261 724005 Principal Investigator MD Garcia~xr13 2iPuig Juan Madrid 28046 SPAIN Hospital Sant Joan Despi (Moisés Broggi) Medicina Interna Jacint Verdaguer, 90 724006 Jerico~xr133 Carlosi Principal Investigator MD Sant Joan Despí 08970 Barcelona SPAIN Hospital Sant Joan Despi (Moisés Broggi) Medicina Interna Jacint Verdaguer, 90 724006 Torrejón Jaramillo Sara Sub-Investigator/Co-Investigator MD Sant Joan Despí 08970 Barcelona SPAIN Hospital Sant Joan Despi (Moisés Broggi) Medicina Interna Jacint Verdaguer, 90 724006 Vila Luis Sub-Investigator/Co-Investigator PhD Sant Joan Despí 08970 Barcelona SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) HOSPITAL UNIVERSITARIO LUCUS AUGUSTI Calle San Cibrao, S/N – Medicina Interna 724007 Casariego~xr134i Emilio Principal Investigator MD 27003 Lugo SPAIN HOSPITAL UNIVERSITARIO LUCUS AUGUSTI Calle San Cibrao, S/N – Medicina Interna 724007 Rigueiro Veloso Maria Teresa Sub-Investigator/Co-Investigator MD 27003 Lugo SPAIN Hospital universitario Ramón Y Cajal Medicina interna unidad de patologia endotelial Carretera Colmenar Viejo, Km. 9.100 planta beja 724008 Saban~xr135 Ruizi Jose Principal Investigator MD (edificio piramidin) 28034 Madrid SPAIN Hospital universitario Ramón Y Cajal Medicina interna unidad de patologia endotelial Carretera Colmenar Viejo, Km. 9.100 100 planta 724008 Tello Susana Sub-Investigator/Co-Investigator MD beja (edificio piramidin) 28034 Madrid SPAIN Hospital Universitario san Cecilio Av. Doctor Oloriz, 16 724009 Mediavilla~xr136i Garcia Juan Diego Principal Investigator MD 18012 Granada SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Universitario san Cecilio Av. Doctor Oloriz, 16 724009 Gil Blas Sub-Investigator/Co-Investigator MD 18012 Granada SPAIN Hospital Universitario san Cecilio Av. Doctor Oloriz, 16 724009 Jiménez Pilar Sub-Investigator/Co-Investigator MD 18012 Granada SPAIN Xerencia Xeral A Coruňa (antiguo Complejo Hospitalario univ. A Coruňa) Servicio Endocrinologia y Nutricíón 724011 Buňo Soto Manuela Sub-Investigator/Co-Investigator MD Xubias de Arriba, 84 A. Coruña 15006 SPAIN Xerencia Xeral A Coruňa (antiguo Complejo Hospitalario univ. A Coruňa) Xubias de Arriba, 84 724011 Ferreiro Gómez Manuel Sub-Investigator/Co-Investigator MD A. Coruña 15006 SPAIN Xerencia Xeral A Coruňa (antiguo Complejo Hospitalario univ. A Coruňa) Xubias de Arriba, 84 724011 Principal Investigator MD Soto~xr1 Alfonso37i A. Coruña 15006 SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Xerencia Xeral A Coruňa (antiguo Complejo Hospitalario univ. A Coruňa) Xubias de Arriba, 84 724011 Toba Alonso Fernando Sub-Investigator/Co-Investigator MD A. Coruña 15006 SPAIN Hospital Del Mar Hospital de dia d’endocrinologia. Edifici de consultes externes. Ip Passeig Marítim, 25-29 724012 Principal Investigator MD Flores~xr138 Juanai Barcelona 08003 Barcelona SPAIN Hospital Del Mar Hospital de dia d’endocrinologia. Edifici de consultes externes. Ip. Passeig Marítim, 25-29 724012 Mañé Serra Laura Sub-Investigator/Co-Investigator MD Barcelona 08003 Barcelona SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Quiron Palmaplanas Consultes externes Medicina Interna (B10) Despatx endocrinologia Camí dels Reis, 308.- Autovía Palma- Andratx, 724013 Gil Apolonia Sub-Investigator/Co-Investigator MD salida 5B Palma De Mallorca 07010 Illes Balears SPAIN Hospital Quiron Palmaplanas Consultes externes Medicina Interna (B10) Despatx endocrinologia Camí dels Reis, 308.- Autovía Palma- Andratx, 724013 Gomez~xr139 Luisi Alberto Principal Investigator MD salida 5B Palma De Mallorca 07010 Illess Balears SPAIN Hospital Quiron Palmaplanas Consultes externes Medicina Interna (B10) Despatx endocrinologia Camí dels Reis, 308.- Autovía Palma- Andratx, 724013 Masmiquel Luis Sub-Investigator/Co-Investigator MD salida 5B Palma De Mallorca 07010 Illes Balears SPAIN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Hospital Quiron Palmaplanas Consultes externes Medicina Interna (B10) Despatx endocrinologia Camí dels Reis, 308.- Autovía Palma- Andratx, 724013 RiveraRosmeri Sub-Investigator/Co-Investigator MD salida 5BPalma De Mallorca 07010 Illes Balears SPAIN Medicinkliniken, Ljungby lasarett Medicinmottagningen Ljungby Lasarett 752001 Fabian Botond Sub-Investigator/Co-Investigator MD Ljungby 341 82 SWEDEN Medicinkliniken, Ljungby lasarett Medicinmottagningen Ljungby Lasarett 752001 Principal Investigator MD Svensson~xr140i Karl-Axel Ljungby 341 82 SWEDEN S3 Clinical Research Centers Indalsbacken 1, 2tr 752002 Liu~xr141i Bo Principal Investigator MD Vällingby 162 68 SWEDEN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Pharmasite Föreningsgatan 26 3tr 752003 Ericsson Ulla-Britt Sub-Investigator/Co-Investigator MD,PhD Malmö 211 52 SWEDEN Pharmasite Föreningsgatan 26 3tr 752003 Koskinen~xr142i Pekka Principal Investigator MD Malmö 211 52 SWEDEN Dalecarlia Clinical Research Center Torggatan 18 752004 Larnefeldt~xr143i Hans Principal Investigator MD Rättvik 795 30 SWEDEN Medect Clinical Trials Karlavägen 100 752005 Bragee~xr144i Bjorn Principal Investigator MD Stockholm SE-11526 SWEDEN Medect Clinical TrialsKarlavägen 100 Stockholm 752005 Lindborg Göran Sub-Investigator/Co-Investigator MD SE-11526 SWEDEN Medect Clinical TrialsKarlavägen 100 Stockholm 752005 Årfors Leopold Sub-Investigator/Co-Investigator MD SE-11526 SWEDEN

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regional Communal institution,”Chernivtsi regional endocrinology center”, out-patient-Department 50, Fedkovycha Str. 804002 Principal Investigator MD Pashkovska~xr145i Nataliia Chernivtsi 58022 UKRAINE Regional Communal institution,”Chernivtsi regional endocrinology center”, out-patient-Department 50, Fedkovycha Str. 804002 Stankova Nina Sub-Investigator/Co-Investigator MD Chernivtsi 58022 UKRAINE Institute of endocrinology and metabolism 69, Vyshgorodska str 804006 Ivaskiva Kateryna Sub-Investigator/Co-Investigator MD Kyiv 04114 UKRAINE Institute of endocrinology and metabolism 69, Vyshgorodska str 804006 Orlenko~xr146 iValeriia Principal Investigator MD Kyiv 04114 UKRAINE Institute of endocrinology and metabolism 69, Vyshgorodska str 804006 Tronko Mykola Sub-Investigator/Co-Investigator MD Kyiv 04114 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Administration of med services and rehabilitation of ARTEM,outpatient department 17-V, Dehtyarivska str. 804007 Logoida Pavlo Sub-Investigator/Co-Investigator MD Kyiv 04050 UKRAINE Administration of med services and rehabilitation of ARTEM,outpatient department 17-V, Dehtyarivska str. 804007 Lykhoshapko Olena Sub-Investigator/Co-Investigator MD Kyiv 04050 UKRAINE Administration of med services and rehabilitation of ARTEM,outpatient department 17-V, Dehtyarivska str. 804007 Principal Investigator MD, PhD Mankovsky~xr147i Borys Kyiv 04050 UKRAINE Administration of med services and rehabilitation of ARTEM,outpatient department 17-V, Dehtyarivska str. 804007 Zherdova Nadiia Sub-Investigator/Co-Investigator MD, PhD Kyiv 04050 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Vinytsya Regional Clinical Highly specialized EC, Therapeutic department Suite 2 804008 Semenyuk Inna Sub-Investigator/Co-Investigator MD 32, Michuryna Str. Vinnytsya 21010 UKRAINE Regional Clinical Highly specialized EC 32, Michuryna Str. 804008 Slobodianiuk Ganna Sub-Investigator/Co-Investigator MD Vinnytsya 21010 UKRAINE Regional Clinical Highly specialized EC 32, Michuryna Str. 804008 Vlasenko~xr148i Maryna Principal Investigator Prof Vinnytsya 21010 UKRAINE Regional Clinical Hospital, Department of endocrinology 91, Fedkovycha Str. 804009 Principal Investigator MD Gavrylyuk~xr149i Volodymyr Ivano-Frankovsk 76008 UKRAINE Regional Clinical Hospital, Department of endocrinology 91, Fedkovycha Str. 804009 Marusyn Oksana Sub-Investigator/Co-Investigator MD Ivano-Frankovsk 76008 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regional Clinical Hospital, Department of endocrinology 91, Fedkovycha Str. 804009 Popovych Lilya Sub-Investigator/Co-Investigator MD Ivano-Frankovsk 76008 UKRAINE Railway Clinical Hospital #2 of Kyiv station DTGO "SR" 9, Povitroflotskyy ave 804010 Kleban Yaroslav Sub-Investigator/Co-Investigator MD Kyiv 03049 UKRAINE State institution “Railway Clinical Hospital #2 of Kyiv station DTGO "SR", Department of Endocrinology 804010 Mishanich Oleg Sub-Investigator/Co-Investigator MD 9, Povitroflotskyy ave Kyiv 03049 UKRAINE Railway Clinical Hospital #2 of Kyiv station DTGO "SR" 9, Povitroflotskyy ave 804010 Principal Investigator MD Myshanych~xr150i Halyna Kyiv 03049 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Railway Clinical Hospital #2 of Kyiv station DTGO "SR" 9, Povitroflotskyy ave 804010 Zalievska Tetiana Sub-Investigator/Co-Investigator MD Kyiv 03049 UKRAINE Private Small-Scale Enterprise Medical Centre "Pulse" 34, Timiryazeva str. 804011 Principal Investigator MD Mostovoy~xr151i Yuriy Vinnytsya 21001 UKRAINE Private Small-Scale Enterprise Medical Centre "Pulse" 34, Timiryazeva str. 804011 Motsiuk Olga Sub-Investigator/Co-Investigator MD Vinnytsya 21001 UKRAINE Private Small-Scale Enterprise Medical Centre "Pulse" 34, Timiryazeva str. 804011 Pentiuk Nataliia Sub-Investigator/Co-Investigator MD Vinnytsya 21001 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Private Small-Scale Enterprise Medical Centre "Pulse" 34, Timiryazeva str. 804011 Tomashkevych Halyna Sub-Investigator/Co-Investigator MD Vinnytsya 21001 UKRAINE Lviv Regional Endocrinology Dispensary Out-patient Department 1, Ostrozkogo Str 804012 Principal Investigator MD Kikhtyak~xr152i Olesya Lviv 79010 UKRAINE Lviv Regional Endocrinology Dispensary Out- patient Department 1, Ostrozkogo Str 804012 Moskva Khrystyna Sub-Investigator/Co-Investigator PhD Lviv 79010 UKRAINE Lviv Regional Endocrinology Dispensary Out- patient Department 1, Ostrozkogo Str 804012 Safonova Oksana Sub-Investigator/Co-Investigator PhD Lviv 79010 UKRAINE

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Lviv Regional Endocrinology Dispensary Out- patient Department 1, Ostrozkogo Str 804012 Vendzilovych Yuriy Sub-Investigator/Co-Investigator MD Lviv 79010 UKRAINE WISDEM Centre University Hospital Coventry and Warwickshire Clifford Bridge Road 826001 Principal Investigator MBBS, MRCP Barber~xr153 Thomasi Coventry CV2 2DX UNITED KINGDOM WISDEM Centre University Hospital Coventry and Warwickshire Clifford Bridge Road 826001 Kumar Sudhesh Sub-Investigator/Co-Investigator MBBS,FRCPath Coventry CV2 2DX UNITED KINGDOM WISDEM Centre University Hospital Coventry and Warwickshire Clifford Bridge Road 826001 Williams Jane Sub-Investigator/Co-Investigator MBChB, MBA Coventry CV2 2DX UNITED KINGDOM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes Support Unit Level 8, Ninewells Hospital And Medical School Ninewells Drive 826002 Illsley Graham Sub-Investigator/Co-Investigator MBChB Dundee DD1 9SY UNITED KINGDOM Diabetes Support Unit Level 8, Ninewells Hospital And Medical School Ninewells Drive 826002 Principal Investigator FCRP, MBChB McCrimmon~xr154i Rory Dundee DD1 9SY UNITED KINGDOM Norwish Medical School Clinical Research & Trials Unit Univeristy of East Anglia 826003 Ewing Jane Sub-Investigator/Co-Investigator MBChB, DRCOG Norwish NR4 7TJ Norfolk UNITED KINGDOM Norwish Medical School Clinical Research & Trials Unit Univeristy of East Anglia 826003 Sampson Michael Sub-Investigator/Co-Investigator MBBS,FRCP Norwish NR4 7TJ Norfolk UNITED KINGDOM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Norwish Medical School Clinical Research & Trials Unit Univeristy of East Anglia 826003 Turner~xr155 Jeremyi Principal Investigator MBBS, MRCP Norwish NR4 7TJ Norfolk UNITED KINGDOM The Cedar Centre Royal Surrey County Hospital Egerton Road 826006 Davidson Susan Sub-Investigator/Co-Investigator MBBS, MRCGP Guildford GU2 7XX Surrey UNITED KINGDOM The Cedar Centre Royal Surrey County Hospital Egerton Road 826006 Garesse Robert Sub-Investigator/Co-Investigator MBChB Guildford GU2 7XX Surrey UNITED KINGDOM The Cedar Centre Royal Surrey County Hospital Egerton Road 826006 Herring Roselle Sub-Investigator/Co-Investigator MBBS,MRCP Guildford GU2 7XX Surrey UNITED KINGDOM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) The Cedar Centre Royal Surrey County Hospital Egerton Road 826006 Horden Victoria Sub-Investigator/Co-Investigator MBBS, MRCP Guildford GU2 7XX Surrey UNITED KINGDOM The Cedar Centre Royal Surrey County Hospital Egerton Road 826006 Russell-Jones~xr156i David Principal Investigator MBBS, FRCP Guildford GU2 7XX Surrey UNITED KINGDOM Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Chatterjee Sudesna Sub-Investigator/Co-Investigator MBBS, FRCP Leicester LE5 4PW UNITED KINGDOM Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Principal Investigator MBChB, FRCP Davies~xr157i Melanie Leicester LE5 4PW UNITED KINGDOM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Hamidreza Mani Sub-Investigator/Co-Investigator MD, MRCP Leicester LE5 4PW UNITED KINGDOM Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Meakin Lesley Sub-Investigator/Co-Investigator MBChB, MRCGP Leicester LE5 4PW UNITED KINGDOM Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Quinn Mary Sub-Investigator/Co-Investigator MBChB Leicester LE5 4PW UNITED KINGDOM Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Webb David Sub-Investigator/Co-Investigator MBChB, MRCP Leicester LE5 4PW UNITED KINGDOM

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes research, Leicester Diabetes Centre Leicester General Hospital Gwendolen Road 826007 Htike Zin Zin Sub-Investigator/Co-Investigator MBBS, MRCP Leicester LE5 4PW UNITED KINGDOM Alzohaili Medical Consultants 1331 Monroe St. Suite 100 840001 Alzohaili~xr158i Opada Principal Investigator MD Dearborn 48124 Michigan UNITED STATES Alzohaili Medical Consultants 1331 Monroe St. Suite 100 840001 Krakauer Jesse Charles Sub-Investigator/Co-Investigator MD Dearborn 48124 Michigan UNITED STATES Alzohaili Medical Consultants 1331 Monroe St. Suite 100 840001 Whelan Sheila Sub-Investigator/Co-Investigator NP, CDE Dearborn 48124 Michigan UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) San Diego Coastal Endocrinology Group aMC 340 Fourth Ave Suite 7A 840002 Argoud~xr159 Georgesi Principal Investigator MD Chula Vista 91910 California UNITED STATES San Diego Coastal Endocrinology Group aMC 340 Fourth Ave Suite 7A 840002 Argoud Maria Sub-Investigator/Co-Investigator MS (PA-C) Chula Vista 91910 California UNITED STATES San Diego Coastal Endocrinology Group aMC 340 Fourth Ave Suite 7A 840002 Martin Brian Sub-Investigator/Co-Investigator PA-C Chula Vista 91910 California UNITED STATES Research Institute Of Dallas 10260 North Central Expressway Suite 100N 840003 Aronoff~xr160 Stepheni Principal Investigator MD Dallas 07531 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Research Institute Of Dallas 10260 North Central Expressway Suite 100N 840003 Dorfman Steven Sub-Investigator/Co-Investigator MD Dallas 07531 Texas UNITED STATES Research Institute Of Dallas 10260 North Central Expressway Suite 100N 840003 Miklius Audrey Sub-Investigator/Co-Investigator MD Dallas 07531 Texas UNITED STATES Research Institute Of Dallas 10260 North Central Expressway Suite 100N 840003 Sachson Richard Sub-Investigator/Co-Investigator MD Dallas 07531 Texas UNITED STATES Research Institute Of Dallas 10260 North Central Expressway Suite 100N 840003 Schill Joseph Sub-Investigator/Co-Investigator ANP Dallas 07531 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Apking Sarah Sub-Investigator/Co-Investigator BA Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Arora~xr16 Samir1i Principal Investigator MD Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Basree Mustafa Sub-Investigator/Co-Investigator BS Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Ceo Sarah Sub-Investigator/Co-Investigator BS Columbus 43213 Ohio UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Cohen Phillip Sub-Investigator/Co-Investigator BS Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Doucet Karla Sub-Investigator/Co-Investigator MA, BS Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Finley Elizabeth (Beth) Sub-Investigator/Co-Investigator RN Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Garrison Mallory Sub-Investigator/Co-Investigator MA Columbus 43213 Ohio UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Nelson Elizabeth Sub-Investigator/Co-Investigator RN Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Notestine Jennifer Sub-Investigator/Co-Investigator RN Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 Robbins Gary Sub-Investigator/Co-Investigator BS Columbus 43213 Ohio UNITED STATES Columbus Clinical Research 99 N Brice Rd. Suite 260 840004 St. John Roy Sub-Investigator/Co-Investigator MD Columbus 43213 Ohio UNITED STATES

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840005 Azizad~xr162i Masoud Principal Investigator MD Northridge 91325 California UNITED STATES Masoud Azizad, PC 18433 Roscoe Blvd. Suite 208 840005 Brown Monica Sub-Investigator/Co-Investigator NO Northridge 91325 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Masoud Azizad, PC 18433 Roscoe Blvd. Suite 208 840005 Chow Christopher Sub-Investigator/Co-Investigator MD Northridge 91325 California UNITED STATES Masoud Azizad, PC 18433 Roscoe Blvd. Suite 208 840005 Gutierrez Haydee Sub-Investigator/Co-Investigator CCRP Northridge 91325 California UNITED STATES Masoud Azizad, PC 18433 Roscoe Blvd. Suite 208 840005 Toven Julie Sub-Investigator/Co-Investigator CCRP Northridge 91325 California UNITED STATES Masoud Azizad, PC 18433 Roscoe Blvd. Suite 208 840005 Kamrava David Sub-Investigator/Co-Investigator MD Northridge 91325 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Principal Investigator MD Bailey~xr163 Timothyi Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Bedolla Laura Sub-Investigator/Co-Investigator CCRC Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Bedolla Yvonne Sub-Investigator/Co-Investigator CRC Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Cobb Kristi Sub-Investigator/Co-Investigator CRC Escondido CA 92025 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Davis Trent Sub-Investigator/Co-Investigator PA-C Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Franco-Cline Carmen Sub-Investigator/Co-Investigator CCRC Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Frazier Amy Sub-Investigator/Co-Investigator CRC Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Ibarra Brandee Sub-Investigator/Co-Investigator CRC Escondido CA 92025 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Jannesari Roya Sub-Investigator/Co-Investigator MSN Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Joaquin Jane Sub-Investigator/Co-Investigator CCRC Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Mckay Tracy Sub-Investigator/Co-Investigator LVN Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Owens Angela Sub-Investigator/Co-Investigator CCRC Escondido CA 92025 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Varma Chandrasekhar Sub-Investigator/Co-Investigator MD Escondido CA 92025 UNITED STATES AMCR Institute 625 West Citracado Pkwy. Suite 112 840006 Walsh John Sub-Investigator/Co-Investigator PA Escondido CA 92025 UNITED STATES L-MARC Research Center 3288 Illinois Ave. Louisville 840007 Principal Investigator MD Bays~xr1 6Harold4i 40213 Kentucky UNITED STATES L-MARC Research Center 3288 Illinois Ave. Louisville 840007 Moore Melanie Sub-Investigator/Co-Investigator APRN 40213 Kentucky UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) L-MARC Research Center 3288 Illinois Ave. Louisville 840007 Ritchey Barbara Michelle Sub-Investigator/Co-Investigator APRN 40213 Kentucky UNITED STATES L-MARC Research Center 3288 Illinois Ave. Louisville 840007 Smith Danielle Sub-Investigator/Co-Investigator APRN 40213 Kentucky UNITED STATES American Health Network of Indiana, LLC 1300 W. Jefferson Street Suite C 840008 Beavins~xr165 i Jill Principal Investigator MD Franklin 46131 Tennessee UNITED STATES American Health Network of Indiana, LLC 1300 W. Jefferson Street Suite C 840008 Bogardus Christine Sub-Investigator/Co-Investigator RN Franklin 46131 Tennessee UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) American Health Network of Indiana, LLC 1300 W. Jefferson Street Suite C 840008 Bogardus Donald Sub-Investigator/Co-Investigator CRC Franklin 46131 Tennessee UNITED STATES American Health Network of Indiana, LLC 1300 W. Jefferson Street Suite C 840008 Cornett George Sub-Investigator/Co-Investigator MD Franklin 46131 Tennessee UNITED STATES International Diabetes Center 3800 Park Nicollet Blvd Minneapolis 840009 Principal Investigator MD Bergenstal~xr166i Richard 55416 Minnesota UNITED STATES International Diabetes Center 3800 Park Nicollet Blvd Minneapolis 840009 Madden Marcia Sub-Investigator/Co-Investigator MPH 55416 Minnesota UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) International Diabetes Center 3800 Park Nicollet Blvd Minneapolis 840009 Stoffels Dawn Sub-Investigator/Co-Investigator RN 55416 Minnesota UNITED STATES International Diabetes Center 3800 Park Nicollet Blvd Minneapolis 840009 Strock Elinor Sub-Investigator/Co-Investigator ANP-BC 55416 Minnesota UNITED STATES Holston Medical Group 105 W. Stone Drive Suite 3B 840010 Bestermann~xr167i Jr. William Principal Investigator MD Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 Glass Mary Sub-Investigator/Co-Investigator LPN Kingsport 37660 Tennessee UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Holston Medical Group 105 W. Stone Drive Suite 3B 840010 Hensley Tara Hope Sub-Investigator/Co-Investigator CRC Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 Morawski Emily Sub-Investigator/Co-Investigator MD Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 Morin David Sub-Investigator/Co-Investigator MD Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 Sturm Donna Sub-Investigator/Co-Investigator CCRC Kingsport 37660 Tennessee UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Holston Medical Group 105 W. Stone Drive Suite 3B 840010 Taylor Peggy Sub-Investigator/Co-Investigator MD Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 Hensley Tara Hope Sub-Investigator/Co-Investigator CRC Kingsport 37660 Tennessee UNITED STATES Holston Medical Group P.C. 105 W. Stone Drive Suite 3B 840010 White~xr168 Judithi Principal Investigator MD Kingsport 37660 Tennessee UNITED STATES UNM Clinical and Translational Science Center, CRU 900 Camino de Salud, Suite 2200 840011 Bouchonville Matthew Sub-Investigator/Co-Investigator MD Albuquerque 87106 New MEXICO UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) UNM Clinical and Translational Science Center , CRU 900 Camino de Salud, Suite 2200 840011 Burge~xr169 Marki Principal Investigator MD Albuquerque 87106 New MEXICO UNITED STATES UNM Clinical and Translational Science Center 900 Camino de Salud, Suite 2200 Albuquerque 840011 Khawaja Hadya Sub-Investigator/Co-Investigator MS 87131 New MEXICO UNITED STATES UNM Clinical and Translational Science Center 900 Camino de Salud, Suite 2200 Albuquerque 840011 Mares Margaret Sub-Investigator/Co-Investigator CRC 87131 New MEXICO UNITED STATES Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 Valparaiso 840012 Ames Jay Timothy Sub-Investigator/Co-Investigator MD 46383 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 Valparaiso 840012 Principal Investigator MD Buynak~xr170 iRobert 46383 Indiana UNITED STATES Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 Valparaiso 840012 Canada Desiree Sub-Investigator/Co-Investigator CRC 46383 Indiana UNITED STATES Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 Valparaiso 840012 Stephan Kathryn Sub-Investigator/Co-Investigator CRC 46383 Indiana UNITED STATES Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 Valparaiso 840012 Volom Patricia Sub-Investigator/Co-Investigator CRC 46383 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s)

Robert Buynak Clinical Reasearch, P.C. 55 University Drive, Suite 106 840012 Yarosz Mark Sub-Investigator/Co-Investigator MS Valparaiso 46383 Indiana UNITED STATES John Muir Physician Network Clinical Research Center 2700 Grant Ave. Suite 202 840013 Principal Investigator MD Chang~xr171i Anna Concord 94520 California UNITED STATES John Muir Physician Network Clinical Research Center 2700 Grant Street . Suite 202 840013 Kaplan Roy Sub-Investigator/Co-Investigator MD Concord 94520 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) John Muir Physician Network Clinical Research Center 2700 Grant Ave. Suite 202 840013 Zlock Douglas Sub-Investigator/Co-Investigator MD Concord 94520 California UNITED STATES Suncoast Clinical Research, Inc. 5604 Gulf Drive New Port Richey 840014 Principal Investigator DO Cohen~xr172i Lisa 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Encarnacion FRANCEs Sub-Investigator/Co-Investigator CRC 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Hasan Syed Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Hicks Melissa Sub-Investigator/Co-Investigator CRC 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Janicka Ania Sub-Investigator/Co-Investigator DO 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Kersey Angela Sub-Investigator/Co-Investigator CRC 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Loman Lusiana Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Penabad Jesus Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Pinero Antonio-Piloña Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Puente Pierre Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Rosario Cristobal Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Suncoast Clinical Research 5604 Gulf Drive New Port Richey 840014 Smith Krystal Sub-Investigator/Co-Investigator CCRP 34652 Florida UNITED STATES American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 Alfata Sarab Sub-Investigator/Co-Investigator MD Muncie 47304 UNITED STATES American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 Condit~xr17 3Jonathani Principal Investigator DO Muncie 47304 UNITED STATES American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 Luttman John Sub-Investigator/Co-Investigator BS Muncie 47304 UNITED STATES American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 Reedy Mark Sub-Investigator/Co-Investigator MD Muncie 47304 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 Shaeffer Laura Sub-Investigator/Co-Investigator MA Muncie 47304 UNITED STATES American Health Network of Indiana, LLC 3631 N Morrison Rd. 840015 White Adrian Sub-Investigator/Co-Investigator CCRP Muncie 47304 UNITED STATES Advanced Medical Research, LLC 6450 Wheatstone Ct. Maumee 840016 Principal Investigator MD Daboul~xr174i Nizar 43537 Ohio UNITED STATES Advanced Medical Research, LLC 6450 Wheatstone Ct. Maumee 840016 Khamousia Nidaa Sub-Investigator/Co-Investigator MD 43537 Ohio UNITED STATES Scripps Whittier Diabetes Institute 9894 Genesee Avenue 1st Floor Suite 120 840017 Chang Amy Sub-Investigator/Co-Investigator MD La Jolla 92037 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Scripps Whittier Diabetes Institute 9894 Genesee Avenue 1st Floor Suite 120 840017 Dailey~xr17 5IIIi George Principal Investigator MD La Jolla 92037 California UNITED STATES Scripps Whittier Diabetes Institute 9894 Genesee Avenue 1st Floor Suite 120 840017 Mccallum James David Ogilvy Sub-Investigator/Co-Investigator MD La Jolla 92037 California UNITED STATES Scripps Whittier Diabetes Institute 9894 Genesee Avenue 1st Floor Suite 120 840017 Philis-Tsimikas Athena Sub-Investigator/Co-Investigator MD La Jolla 92037 California UNITED STATES Scripps Whittier Diabetes Institute 9894 Genesee Avenue 1st Floor Suite 120 840017 Thorsell Ashley Sub-Investigator/Co-Investigator MD La Jolla 92037 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 RNC, WHNP-BC, 840019 Bonecutter Cheryl Sub-Investigator/Co-Investigator San Antonio BSN, MSN 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Denham~xr176i Douglas Principal Investigator DO San Antonio 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Gomez Rosa Sub-Investigator/Co-Investigator MA San Antonio 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Palmer Amanda Sub-Investigator/Co-Investigator CCRC San Antonio 78229 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Rodriguez Lindsay Sub-Investigator/Co-Investigator CCRC San Antonio 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Ryan Terri Lynne Sub-Investigator/Co-Investigator RN San Antonio 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Urrabazo Bethany Sub-Investigator/Co-Investigator CCRC San Antonio 78229 Texas UNITED STATES Clinical Trials of Texas, Inc 7940 Floyd Curl Dr. Suite 700 840019 Vadakekalam Jacob Sub-Investigator/Co-Investigator MD San Antonio 78229 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Department of Veterans Affairs North Texas Healthcare Sysrem, Building 2.8C-CRU 4500 S Lancaster Rd. 840020 Creagan Susan Sub-Investigator/Co-Investigator MD Dallas 75216 Texas UNITED STATES Department of Veterans Affairs North Texas Healthcare Sysrem, Building 2.8C-CRU 4500 S Lancaster Rd. 840020 Dunn~xr177i Fredrick Principal Investigator MD Dallas 75216 Texas UNITED STATES Department of Veterans Affairs North Texas Healthcare Sysrem, Building 2.8C-CRU 4500 S Lancaster Rd. 840020 Welch Evelyn Sub-Investigator/Co-Investigator FNP-BC Dallas 75216 Texas UNITED STATES Department of Veterans Affairs North Texas Healthcare Sysrem, Building 2.8C-CRU 4500 S Lancaster Rd. 840020 Guerra Patricia Sub-Investigator/Co-Investigator PA-C Dallas 75216 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Barber Anthony Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Childres Christopher Sub-Investigator/Co-Investigator CRC Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Cullars Stephanie Sub-Investigator/Co-Investigator CRC Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Donepudi Venkatarama Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202Hickory 28602 840021 Principal Investigator MD Earl~xr17 John8i North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Hemby Katherine Anne Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Hodges James Robinson Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Jones Ann Sub-Investigator/Co-Investigator CRC Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Morgante Patrick John Sub-Investigator/Co-Investigator DO Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Orozco Ian Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202

840021 Polster Scott David Sub-Investigator/Co-Investigator MD Hickory 28602 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Rector Alicia Ferrell Sub-Investigator/Co-Investigator Nurse Practitioner Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Taylor Stephane Sub-Investigator/Co-Investigator CRC Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Woods Michelle Sub-Investigator/Co-Investigator BS Hickory 28602 North Carolina UNITED STATES PMG Research of Hickory 1781 Tate Boulevard SE, Suite 202 840021 Granger Kimberley Sub-Investigator/Co-Investigator CRC Hickory 28602 North Carolina UNITED STATES The Research Group Of Lexington, LLC. 2108 Nicholasville Road Lexington 840022 Principal Investigator MD Farris~xr17 Neil9i 40503 Kentucky UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) The Research Group Of Lexington, LLC. 2108 Nicholasville Road Lexington 840022 Mooney Stephen Sub-Investigator/Co-Investigator MD 40503 Kentucky UNITED STATES The Research Group Of Lexington, LLC. 2108 Nicholasville Road Lexington 840022 Morgan Denise Sub-Investigator/Co-Investigator CCRP 40503 Kentucky UNITED STATES The Research Group Of Lexington, LLC. 2108 Nicholasville Road Lexington 840022 Nichols Jennifer Sub-Investigator/Co-Investigator CCRP 40503 Kentucky UNITED STATES Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Anthony Claire Marie Sub-Investigator/Co-Investigator MS Tempe 85283 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Cadwell Kristina Ann Sub-Investigator/Co-Investigator MS Tempe 85283 Arizona UNITED STATES Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Clayson Danielle Sub-Investigator/Co-Investigator CRC Tempe 85283 Arizona UNITED STATES Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Congdon Erin Sub-Investigator/Co-Investigator CRC Tempe 85283 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Di Tullio-Merrill Nicole Kristine Sub-Investigator/Co-Investigator CCRC Tempe 85283 Arizona UNITED STATES Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Principal Investigator DO Fiel~xr1 Thomas80i Tempe 85283 Arizona UNITED STATES Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Kelln Christine Sub-Investigator/Co-Investigator MA Tempe 85283 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Lopez Jessica Sub-Investigator/Co-Investigator CRC Tempe 85283 Arizona UNITED STATES Clinical Research Advantage, Inc./Fiel Family And Sports Medicine 1840 East Baseline Road Suite C-2 840023 Raban Trisha Sub-Investigator/Co-Investigator CCRP Tempe 85283 Arizona UNITED STATES Diabetes Endocrinology Speclts Inc 222 S Woods Mill Rd Suite 410n Chesterfield 840024 Principal Investigator MD Fishman~xr181i Norman 63017 Missouri UNITED STATES Diabetes Endocrinology Speclts Inc 222 S Woods Mill Rd Suite 410n Chesterfield 840024 Fishman Oiknine Rachel Sub-Investigator/Co-Investigator MD 63017 Missouri UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes Endocrinology Speclts Inc 222 S Woods Mill Rd Suite 410n Chesterfield 840024 Weir Maria Sub-Investigator/Co-Investigator NP-C 63017 Missouri UNITED STATES Medical Education Foundation Northeast Iowa Family Practice center 2055 Kimball Ave 840025 Froyum Roise Adam Sub-Investigator/Co-Investigator MD Waterloo 50702 Iowa UNITED STATES Medical Education Foundation Northeast Iowa Family Practice center 2055 Kimball Ave 840025 Hoehns James Sub-Investigator/Co-Investigator PhD Waterloo 50702 Iowa UNITED STATES Northeast Iowa Medical Education Foundation/ Family Practice center 2055 Kimball Ave 840025 Poock~xr18 2iJames Principal Investigator MD Waterloo 50702 Iowa UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medical Education Foundation Northeast Iowa Family Practice center 2055 Kimball Ave 840025 Welshons Robert Sub-Investigator/Co-Investigator PA-C Waterloo 50702 Iowa UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Apel Jill Frances Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Fogelfeld~xr183i Leon Principal Investigator MD Chicago 60612 Illinois UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Guerra Yannis Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Holt Geraldine Sub-Investigator/Co-Investigator NP Chicago 60612 Illinois UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook Conty 1900 W Polk St. 840026 Kessler Lynn Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Koshy Anoopa Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Manchanda Aarti Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Fantus Diabete Clinic at John H. Stroger, Jr. Hospital of Cook County 1900 W Polk St. 840026 Mascarell Susana Sub-Investigator/Co-Investigator MD Chicago 60612 Illinois UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Avila Vanessa Sub-Investigator/Co-Investigator CCRC Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Archibeck Alisha Sub-Investigator/Co-Investigator DO Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Bauch Thomas Sub-Investigator/Co-Investigator MD Phoenix 85018 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Baxter Brett Sub-Investigator/Co-Investigator CRC Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Benford Carly Sub-Investigator/Co-Investigator BS Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Francyk~xr184i David Principal Investigator DO Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Goldman Allan Sub-Investigator/Co-Investigator DO Phoenix 85018 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Harrison Larissa Sub-Investigator/Co-Investigator BS Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Harvey Sarah Sub-Investigator/Co-Investigator BS Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Ungar Ira Sub-Investigator/Co-Investigator MD Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Montgomery Catherine Sub-Investigator/Co-Investigator RN Phoenix 85018 Arizona UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Sheridan Kathryn Sub-Investigator/Co-Investigator CRC Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Southwell Tyler John Sub-Investigator/Co-Investigator MD Phoenix 85018 Arizona UNITED STATES Clinical Research Advantage Family Practice Specialists 4350 E. Camelback Rd., Suite F100 840027 Wyse Mark Sub-Investigator/Co-Investigator MD Phoenix 85018 Arizona UNITED STATES Grunberger Diabetes Institute 43494 Woodward Avenue, Suite 208 Bloomfield Hills 840028 Aman Linda Sub-Investigator/Co-Investigator MSN 48302 Michigan UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Grunberger Diabetes Institute 43494 Woodward Avenue, Suite 208 Bloomfield Hills 840028 Principal Investigator MD Grunberger~xr185i George 48302 Michigan UNITED STATES Grunberger Diabetes Institute 43494 Woodward Avenue, Suite 208 Bloomfield Hills 840028 Myneni Anjana Sub-Investigator/Co-Investigator MD 48302 Michigan UNITED STATES Metabolic Institute Of America 18372 Clark St. Suite 212 840029 Delkhah Shahin Sub-Investigator/Co-Investigator MD Tarzana 91356 California UNITED STATES Metabolic Institute Of America 18372 Clark St. Suite 212 840029 Handelsman~xr186i Yehuda Principal Investigator MD Tarzana 91356 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 Baron Tatiana Sub-Investigator/Co-Investigator DO 11042 New York UNITED STATES North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 Bloom Ronda Sub-Investigator/Co-Investigator MD 11042 New York UNITED STATES North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 D'Ambra Russell Sub-Investigator/Co-Investigator MD 11042 New York UNITED STATES North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 Principal Investigator MD Hershon~xr187i Kenneth 11042 New York UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 Hirsch Barbara Sub-Investigator/Co-Investigator MD 11042 New York UNITED STATES North Shore Diabetes And Endocrine Associates 3003 New Hyde Park Road, Suite 201 New Hyde Park 840030 Sachmechi Isaac Sub-Investigator/Co-Investigator MD 11042 New York UNITED STATES Clinical Research Advantage Inc 991 Kenmore Drive Evansville 840031 Principal Investigator MD Allaw~xr1 88Mohammedi 47714 Indiana UNITED STATES Clinical Research Advantage Inc 991 Kenmore Drive Evansville 840031 Inzerello Anthony Sub-Investigator/Co-Investigator MD 47714 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage 991 Kenmore Drive Evansville 840031 Morris Jana Sub-Investigator/Co-Investigator CRC 47714 Indiana UNITED STATES Clinical Research Advantage Inc 991 Kenmore Drive Evansville 840031 Morrison Kimberly Diane Sub-Investigator/Co-Investigator BA 47714 Indiana UNITED STATES Clinical Research Advantage Inc 991 Kenmore Drive Evansville 840031 Schucker Georgettea Sub-Investigator/Co-Investigator CCRC 47714 Indiana UNITED STATES Aurora Advanced Healthcare SC 3003 W. Good Hope Road Milwaukee 840033 Principal Investigator MD Jain~xr1 Rajeev89i 53209 Wisconsin UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Aurora Advanced Healthcare SC 3003 W. Good Hope Road Milwaukee 840033 Lim Arnold Sub-Investigator/Co-Investigator MD 53209 Wisconsin UNITED STATES Desert Medical Group,Inc.dba Desert Oasis Healthcare Medical Group 275 N El Cielo Road. 840034 Andresen Teri Sub-Investigator/Co-Investigator CRC Suite D-412 Palm Springs 92262 UNITED STATES Desert Medical Group,Inc.dba Desert Oasis Healthcare Medical Group 275 N El Cielo Rd. 840034 Chavous Donald Sub-Investigator/Co-Investigator MD Suite D-412 Palm Springs 92262 UNITED STATES Desert Medical Group,Inc.dba Desert Oasis Healthcare Medical Group 275 N El Cielo Road. 840034 Figueroa Martin Sub-Investigator/Co-Investigator CRC Suite D-412 Palm Springs 92262 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Desert Medical Group,Inc.dba Desert Oasis Healthcare Medical Group 275 N El Cielo Road. 840034 Flowers FRANCEsca Sub-Investigator/Co-Investigator MD Suite D-412 Palm Springs 92262 UNITED STATES Desert Medical Group,Inc.dba Desert Oasis Healthcare Medical Group 275 N El Cielo Road. 840034 Jardula~xr190 Michaeli Principal Investigator MD Suite D-412 Palm Springs 92262 UNITED STATES Cherry Tree Medical Associates 25 Highland Park Dr. Suite 201 840036 Bennett Cecilia Sub-Investigator/Co-Investigator CNA Uniontown 15401 Pennsylvania UNITED STATES Cherry Tree Medical Associates 25 Highland Park Dr. Suite 201 840036 Billheimer Ruth Sub-Investigator/Co-Investigator MA Uniontown 15401 Pennsylvania UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Cherry Tree Medical Associates 25 Highland Park Dr. Suite 201 840036 Flores May Sub-Investigator/Co-Investigator MD Uniontown 15401 Pennsylvania UNITED STATES Cherry Tree Medical Associates 25 Highland Park Dr. Suite 201 840036 Harring Barbara Sub-Investigator/Co-Investigator MA Uniontown 15401 Pennsylvania UNITED STATES Cherry Tree Medical Associates 25 Highland Park Dr. Suite 201 840036 Joshi~xr1 9Kishor1i Principal Investigator MD Uniontown 15401 Pennsylvania UNITED STATES Focus Clinical Trials 12176 South 1000 East Suite 4 840037 Kasper~xr192i Joseph Principal Investigator MD Draper 84020 Utah UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Focus Clinical Trials 12176 South 1000 East Suite 4 840037 Lopez Ronald Sub-Investigator/Co-Investigator MD Draper 84020 Utah UNITED STATES Focus Clinical Trials 12176 South 1000 East Suite 4 840037 Wright Elizabeth Sub-Investigator/Co-Investigator PA-C Draper 84020 Utah UNITED STATES Cherry Creek Family Practice 425 South Cherry Street Suite 410 840038 Johnson Michael Sub-Investigator/Co-Investigator PA-C Denver 80246 Colorado UNITED STATES Cherry Creek Family Practice 425 South Cherry Street Suite 410 840038 Kreutter Chantelle Sub-Investigator/Co-Investigator CRC Denver 80246 Colorado UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Cherry Creek Family Practice 425 South Cherry Street Suite 410 840038 Kreutter~xr193 i Flory Principal Investigator MD Denver 80246 Colorado UNITED STATES Cherry Creek Family Practice 425 South Cherry Street Suite 410 840038 Schauwecker Allison Sub-Investigator/Co-Investigator CRC Denver 80246 Colorado UNITED STATES Mountain Diabetes and Endocrine Center 1998 Hendersonville Rd Asheville 840039 Principal Investigator MD Lane~xr1 9Wendy4i 28803 North Carolina UNITED STATES Mountain Diabetes and Endocrine Center 1998 Hendersonville Rd Asheville 840039 Rappaport Johnathan Sub-Investigator/Co-Investigator MD 28803 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Mountain Diabetes and Endocrine Center 1998 Hendersonville Rd Asheville 840039 Skzrynski Michael Sub-Investigator/Co-Investigator ANP 28803 North Carolina UNITED STATES Mountain Diabetes and Endocrine Center 1998 Hendersonville Rd Asheville 840039 Weinrib Stephen Sub-Investigator/Co-Investigator MD 28803 North Carolina UNITED STATES Virginia Endocrinology Research 3205 Churchland Blvd. Chesapeake 840040 Gilman Eileen Sub-Investigator/Co-Investigator CCRC 23321 Virginia UNITED STATES Virginia Endocrinology Research 3205 Churchland Blvd. Chesapeake 840040 Principal Investigator MD Larocque~xr195i James 23321 Virginia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Wasatch Clinical Research, LLC (Administrative Location) 4001 South 700 East Suite 105 840041 Daynes Randall Sub-Investigator/Co-Investigator MD Salt Lake City 84107 Utah UNITED STATES Wasatch Clinical Research, LLC (Administrative Location) 4001 South 700 East Suite 105 840041 Fuller Gene Sub-Investigator/Co-Investigator MD Salt Lake City 84107 Utah UNITED STATES Wasatch Clinical Research, LLC (Administrative Location) 4001 South 700 East Suite 105 840041 Principal Investigator MD Larsen~xr196 Davidi Salt Lake City 84107 Utah UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Wasatch Clinical Research, LLC (Administrative Location) 4001 South 700 East Suite 105 840041 Rasmussen Brian Sub-Investigator/Co-Investigator MD Salt Lake City 84107 Utah UNITED STATES Wasatch Clinical Research, LLC (Administrative Location) 4001 South 700 East Suite 105 840041 Young Timothy Sub-Investigator/Co-Investigator MD Salt Lake City 84107 Utah UNITED STATES Creighton Diabetes Center 601 N. 30th, Suite 6715 Omaha 840042 Kuechenmeister Lisa Sub-Investigator/Co-Investigator PA-C 68131 Nebraska UNITED STATES Creighton Diabetes Center 601 N. 30th, Suite 6715Omaha 840042 Rendell~xr197i Marc Principal Investigator MD 68131 Nebraska UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Creighton Diabetes Center 601 N. 30th, Suite 6715 Omaha 840042 Storey Anne Sub-Investigator/Co-Investigator PA-C 68131 Nebraska UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard 840043 Batrus Jennifer Sub-Investigator/Co-Investigator PA-C Tipton 46214-2985 Pennsylvania UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard Tipton 840043 Confer Melissa Sub-Investigator/Co-Investigator CRC 16684 Pennsylvania UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard 840043 Conrad Amanda Sub-Investigator/Co-Investigator CRC Tipton 46214-2985 Pennsylvania UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard 840043 Edevane Shari Sub-Investigator/Co-Investigator RN Tipton 46214-2985 Pennsylvania UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard Tipton 840043 Principal Investigator MD Levinson~xr198i Lawrence 46214-2985 Pennsylvania UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard 840043 Reinhardt John Sub-Investigator/Co-Investigator DO Tipton 46214-2985 Pennsylvania UNITED STATES Tipton Medical And Diagnostic Center 4371 East Pleasant Valley Boulevard 840043 Shawley Sarah Sub-Investigator/Co-Investigator CRC Tipton 46214-2985 Pennsylvania UNITED STATES National Research Institute 2010 Wilshire Blvd Suite 302 Los Angeles 840044 Principal Investigator MD Frias~xr1 99Juani 90057 California UNITED STATES National Research Institute 2010 Wilshire Blvd Suite 302 Los Angeles 840044 Hsia Stanley Hsin-Wei Sub-Investigator/Co-Investigator MD 90057 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) National Research Institute 2010 Wilshire Blvd Suite 302 Los Angeles 840044 Kelly Sharon Sub-Investigator/Co-Investigator NP 90057 California UNITED STATES National Research Institute 2010 Wilshire Blvd Suite 302 Los Angeles 840044 Lewin Andrew Sub-Investigator/Co-Investigator MD 90057 California UNITED STATES National Research Institute 2010 Wilshire Blvd Suite 302 Los Angeles 840044 Sandoval Rose Sub-Investigator/Co-Investigator NP 90057 California UNITED STATES York Clinical Research, LLC. 142 West York Street, Suite 905 Norfolk 840045 Dashiell Carie Sub-Investigator/Co-Investigator CRC 23510 Virginia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) York Clinical Research, LLC. 142 West York Street, Suite 905 Norfolk 840045 Principal Investigator MD Lovell~xr200 Charlesi 23510 Virginia UNITED STATES York Clinical Research, LLC. 142 West York Street, Suite 905 Norfolk 840045 Newby James Sub-Investigator/Co-Investigator MD 23510 Virginia UNITED STATES York Clinical Research, LLC. 142 West York Street, Suite 905 Norfolk 840045 Pecsok Thomas Sub-Investigator/Co-Investigator MD 23510 Virginia UNITED STATES Diabetes & Endocrinology Consultants 611 N 35th St. Morehead City 840046 Ferree Kristin Gainey Sub-Investigator/Co-Investigator FNP 28557 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes & Endocrinology Consultants 611 N 35th St. Morehead City 840046 Principal Investigator MD Lucas~xr20 Kathryn1i 28557 North Carolina UNITED STATES Endocrine Associates of Florida 1530 Citrus Medical Ct. Suite 103 840047 Curtis Craig Sub-Investigator/Co-Investigator MD Ocoee 34761 Florida UNITED STATES Endocrine Associates of Florida 1530 Citrus Medical Ct. Suite 103 840047 Mandry~xr202i Jose Principal Investigator MD Ocoee 34761 Florida UNITED STATES Indiana University Health Physicians Endocrinology , Diabetes and Metabolism 201 Pennsylvania Parkway, suite 310 840048 Mariash~xr203 i Cary Principal Investigator MD Indianapolis 46280 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Indiana University Health Physicians Endocrinology , Diabetes and Metabolism suite 310Indianapolis 840048 Meacham James Sub-Investigator/Co-Investigator MD 46202 Indiana UNITED STATES Mountain View Clinical Research Inc 405 Memorial Drive Extension Greer 840049 Ballard Thomas Victor Sub-Investigator/Co-Investigator MD 29651 South Carolina UNITED STATES Mountain View Clinical Research Inc 405 Memorial Drive Extension Greer 840049 Byars William David Sub-Investigator/Co-Investigator MD 29651 South Carolina UNITED STATES Mountain View Clinical Research Inc 405 Memorial Drive Extension Greer 840049 Durham Nancy Sub-Investigator/Co-Investigator DNP 29651 South Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Mountain View Clinical Research Inc 405 Memorial Drive Extension Greer 840049 Principal Investigator MD Mayfield~xr204i Ronald 29651 South Carolina UNITED STATES Mountain View Clinical Research Inc 405 Memorial Drive Extension Greer 840049 Wood Ruth Denise Sub-Investigator/Co-Investigator RNP 29651 South Carolina UNITED STATES HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Suite 300 840050 Backus Arnetta Sub-Investigator/Co-Investigator RN Springfield 62704 Illinois UNITED STATES HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Suite 300 840050 Dukett Mary Sub-Investigator/Co-Investigator RN Springfield 62704 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Suite 300 840050 Jayaramaiah Poornima Sub-Investigator/Co-Investigator MD Springfield 62704 Illinois UNITED STATES HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Family Nurse Suite 300 840050 Mccall Linda Sub-Investigator/Co-Investigator Practitioner Springfield 62704 Illinois UNITED STATES HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Suite 300 840050 Principal Investigator MD Mikell~xr205 Franki Springfield 62704 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) HSHS Medical Group,InC Springfield Diabetes and Endocrine Center 2501 Chatham Road Suite 300 840050 Nallala Deepika Sub-Investigator/Co-Investigator MD Springfield 62704 Illinois UNITED STATES Research Management Inc. 12221 N MoPac Expressway Austin 840051 Cook Linda Joan Sub-Investigator/Co-Investigator FNP 78758 Texas UNITED STATES Research Management Inc. 12221 N MoPac Expressway Austin 840051 Juneja Kavita Sondh Sub-Investigator/Co-Investigator MD 78758 Texas UNITED STATES Research Management Inc. 12221 N MoPac Expressway Austin 840051 Malish Rachel Allison Sub-Investigator/Co-Investigator ACNS 78758 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Research Management Inc. 12221 N MoPac Expressway Austin 840051 Principal Investigator MD Moore~xr206 Pauli 78758 Texas UNITED STATES Palm Research Center 9280 W. Sunset Road Suite 306 840052 Bowers Rachel Cora Sub-Investigator/Co-Investigator PA-C Las Vegas 89148 Nevada UNITED STATES Palm Research Center 9280 W. Sunset Road Suite 306 840052 Klugh Serena Ann Sub-Investigator/Co-Investigator MD Las Vegas 89148 Nevada UNITED STATES Palm Research Center 9280 W. Sunset Road Suite 306 840052 Nakhle~xr207i Samer Principal Investigator MD Las Vegas 89148 Nevada UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Palm Research Center 9280 W. Sunset Road Suite 306 840052 Palal Betsy Sub-Investigator/Co-Investigator MD Las Vegas 89148 Nevada UNITED STATES Valley Research 550 E Herndon Ave. Suite 101 840053 Flowe Chelsea Sub-Investigator/Co-Investigator FNP Fresno 93720 California UNITED STATES Valley Research 550 E Herndon Ave. Suite 101 840053 Norwood~xr208i Paul Principal Investigator MD Fresno 93720 California UNITED STATES Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Arkin David Sub-Investigator/Co-Investigator MD 30046 Georgia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Goswami Ketan Sub-Investigator/Co-Investigator MD 30046 Georgia UNITED STATES Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Lu Peter Sub-Investigator/Co-Investigator MD 30046 Georgia UNITED STATES Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Mahakala Aparna Sub-Investigator/Co-Investigator MD 30046 Georgia UNITED STATES Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Principal Investigator MD Odugbesan~xr209i Adeniyi 30046 Georgia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Physician's Research Associates, LLC 758 Old Norcorss Rd, Suite 175 Lawrenceville 840054 Shore David Sub-Investigator/Co-Investigator MD 30046 Georgia UNITED STATES Endocrine Associates, LLC 5711 Almeda Road Houston 840055 Principal Investigator MD Bueso~xr21 0Gerardoi 77004 Texas UNITED STATES Endocrine Associates, LLC 5711 Almeda Road Houston 840055 Wenske Natalie Sub-Investigator/Co-Investigator PAC 77004 Texas UNITED STATES Suncoast Clinical Research, Inc Clinical Research 5604 Gulf Drive 840056 Bayne Deanna Sub-Investigator/Co-Investigator Practitioner 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Cohen Lisa Sub-Investigator/Co-Investigator DO 34652 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Condit Allison Sub-Investigator/Co-Investigator CRC 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Goldstein Gary Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Hester Bridget Sub-Investigator/Co-Investigator CRC 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Janicka Ania Sub-Investigator/Co-Investigator DO 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Lorello Michael Sub-Investigator/Co-Investigator PA-C 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Neri Karena Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Polin Arthur Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES

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Suncoast Clinical Research, Inc 840056 Plevin~xr211i Sanford Principal Investigator MD 5604 Gulf Drive 34652 Florida UNITED STATES Suncoast Clinical Research, Inc 5604 Gulf Drive 840056 Puente Pierre Andres Sub-Investigator/Co-Investigator MD 34652 Florida UNITED STATES Eastlake Outpatient Center 3890 Tampa Road Palm Harbor 840056 Rutledge Hugh Sub-Investigator/Co-Investigator MD 34684 Florida UNITED STATES Eastlake Outpatient Center 3890 Tampa Road Palm Harbor 840056 Rosario Cristobal Sub-Investigator/Co-Investigator MD 34684 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Mercury Street Medical Group LLC. 300 W Mercury St. Butte 840057 Principal Investigator MD Pullman~xr212i John 59701 Montana UNITED STATES Mercury Street Medical Group LLC. 300 W Mercury St. Butte 840057 Williams-Leber Erin Sub-Investigator/Co-Investigator PA-C 59701 Montana UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Cooksey Erin Lynn Sub-Investigator/Co-Investigator MD 29621 South Carolina UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Gatlin June Sub-Investigator/Co-Investigator CCRC 29621 South Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Principal Investigator MD Geisberg~xr213i Harry 29621 South Carolina UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Isakov Ingris Laetitia Sub-Investigator/Co-Investigator MD 29621 South Carolina UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Laserna Susan Sub-Investigator/Co-Investigator CCRC 29621 South Carolina UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Reeves Angela Sub-Investigator/Co-Investigator MSN 29621 South Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Widel Michele Sub-Investigator/Co-Investigator CMA 29621 South Carolina UNITED STATES Clinical Research Advantage 2000 E Greenville St. Suite 1600 Anderson 840058 Wright Jaime-Lyn Sub-Investigator/Co-Investigator RN 29621 South Carolina UNITED STATES University of Colorado 12401 E. 17th Avenue Aurora 840059 Douglass Sara Sub-Investigator/Co-Investigator PA-C 80045 Colorado UNITED STATES University of Colorado 12401 E. 17th Avenue Aurora 840059 Principal Investigator MD Rasouli~xr214i Neda 80045 Colorado UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) MediSphere Medical Research Center, LLC 1401 Professional Blvd., Suite 100 Evansville 840060 Dela Llana Alexander Sub-Investigator/Co-Investigator MD 47714 Indiana UNITED STATES MediSphere Medical Research Center, LLC 1401 Professional Blvd., Suite 100 Evansville 840060 Hoebeke Roberta Sub-Investigator/Co-Investigator PhD 47714 Indiana UNITED STATES MediSphere Medical Research Center, LLC 1401 Professional Blvd., Suite 100 Evansville 840060 Principal Investigator MD Reyes~xr21 5Huberti 47714 Indiana UNITED STATES MediSphere Medical Research Center, LLC 1401 Professional Blvd., Suite 100 Evansville 840060 Rutherford Mary Sub-Investigator/Co-Investigator FNP-C 47714 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) MediSphere Medical Research Center, LLC 1401 Professional Blvd., Suite 100 Evansville 840060 Sebastian Mike Gerald Sub-Investigator/Co-Investigator MD 47714 Indiana UNITED STATES Optimum Clinical Research, Inc 82 South 1100 East Suite 402 840061 Rhudy~xr21 6Jacksoni Principal Investigator MD Salt Lake City 84102 Utah UNITED STATES Optimum Clinical Research, Inc 82 South 1100 East Suite 402 840061 Zubair Imran Sub-Investigator/Co-Investigator MD Salt Lake City 84102 Utah UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Avila Vanessa Sub-Investigator/Co-Investigator CCRC Phoenix 85020 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Berry Barbara Sub-Investigator/Co-Investigator MD Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Burrows Jennifer Sub-Investigator/Co-Investigator CRC Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Crawford Meli'Sa Sub-Investigator/Co-Investigator BS Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Harrison Larissa Sub-Investigator/Co-Investigator BS Phoenix 85020 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Haught Annamarie Sub-Investigator/Co-Investigator CDE Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 & 191 840062 Khananisho Paulina Sub-Investigator/Co-Investigator BS Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Lipschitz Barbara Sub-Investigator/Co-Investigator MD Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Principal Investigator MD Riffer~xr217i Ernie Phoenix 85020 UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 190 840062 Sheridan Kathryn Sub-Investigator/Co-Investigator CRC Phoenix 85020 UNITED STATES Clinical Research Advantage Central Phoenix Medical Clinic 7600 N 15th Street, Suite 191 840062 Vesely Kelly Cronin Sub-Investigator/Co-Investigator CCRC Phoenix 85020 UNITED STATES Endocrine and Metabolic Consultants 3200 Tower Oaks Blvd. Suite 250 840063 Dempsey Michael Sub-Investigator/Co-Investigator MD Rockville 20852 Maryland UNITED STATES Endocrine and Metabolic Consultants 3200 Tower Oaks Blvd. Suite 250 840063 Lopez Meyling Sub-Investigator/Co-Investigator MA Rockville 20852 Maryland UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Endocrine and Metabolic Consultants 3200 Tower Oaks Blvd. Suite 250 840063 Rodbard~xr218i Helena Principal Investigator MD Rockville 20852 Maryland UNITED STATES Dallas Diabetes and Endocrine Center 7777 Forest Ln. Suite C-685 840064 Banarer Salomon Sub-Investigator/Co-Investigator MD Dallas 75230 Texas UNITED STATES Dallas Diabetes and Endocrine Center 7777 Forest Ln. Suite C-685 840064 Kniffen Wendy Sub-Investigator/Co-Investigator PA-C Dallas 75230 Texas UNITED STATES Dallas Diabetes and Endocrine Center 7777 Forest Ln. Suite C-685 840064 Rooker-Morris Leslie Anne Sub-Investigator/Co-Investigator PA-C Dallas 75230 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Dallas Diabetes and Endocrine Center 7777 Forest Ln. Suite C-685 840064 Rosenstock~xr219i Julio Principal Investigator MD Dallas 75230 Texas UNITED STATES SunRise Clinical Research, Inc 5985 Florence Ave. Suite N 840065 Hafez Mohamed AMR Sub-Investigator/Co-Investigator MD Bell Gardens 90201 California UNITED STATES SunRise Clinical Research, Inc 5985 Florence Ave. Suite N 840065 Salem~xr22 0Galali Principal Investigator MD Bell Gardens 90201 California UNITED STATES Padre Coast Medical Associates PA 1301 Santa Fe Street Suite B 840066 Albarracin Cesar Sub-Investigator/Co-Investigator MD Corpus Christi 78404 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Padre Coast Clinical Research 1301 Santa Fe Street Suite B 840066 Sandoval~xr221i Jaime Principal Investigator MD Corpus Christi 78404 Texas UNITED STATES Helping Hands Medical Associates, Inc. 2621 S Bristol St. Suite 307 840067 Chueh Daniel Sub-Investigator/Co-Investigator MD Santa Ana 92704 California UNITED STATES Helping Hands Medical Associates, Inc. 2621 S Bristol St. Suite 307 840067 Schwartz~xr222i Alan Principal Investigator MD Santa Ana 92704 California UNITED STATES NorCal Endocrinology 111 Deerwood road suite 180 San Ramon 840068 Lisovskiy Svetlana Sub-Investigator/Co-Investigator PA-C 94583 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) NorCal Endocrinology 111 Deerwood road suite 180 San Ramon 840068 Principal Investigator MD Shlesinger~xr223i Yshay 94583 California UNITED STATES Southern New Hampshire Diabetes & Endocrinology Center 29 Northwest Blvd. 840069 Chuang Ellie Sub-Investigator/Co-Investigator MD Nashua 03063 New Hampshire UNITED STATES Southern New Hampshire Diabetes & Endocrinology Center 29 Northwest Blvd. 840069 Silver~xr224i Robert Principal Investigator MD Nashua 03063 New Hampshire UNITED STATES First Valley Medical Group 44725 N 10th Street West Suite 210 Lancaster 840070 Doriguzzi David Sub-Investigator/Co-Investigator PA-C 93534 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) First Valley Medical Group 44725 N 10th Street West Suite 210 Lancaster 840070 Kujmanian Leon Sub-Investigator/Co-Investigator MD 93534 California UNITED STATES First Valley Medical Group 44725 N 10th Street West Suite 210 Lancaster 840070 Pascal Aileen Sub-Investigator/Co-Investigator BA 93534 California UNITED STATES First Valley Medical Group 44725 N 10th Street West Suite 210 Lancaster 840070 Radillo Jocelyn Sub-Investigator/Co-Investigator CRC 93534 California UNITED STATES First Valley Medical Group 44725 N 10th Street West Suite 210 Lancaster 840070 Principal Investigator MD Sivalingam~xr225i Kanagaratnam 93534 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Clinical Research Institute of Michigan 30795 23 Mile Rd. Suite 206 840071 Fogel Ronald Sub-Investigator/Co-Investigator MD Chesterfield 48047 Michigan UNITED STATES Clinical Research Institute of Michigan 30795 23 Mile Rd. Suite 206 840071 Muszkat Yakir Sub-Investigator/Co-Investigator MD Chesterfield 48047 Michigan UNITED STATES Clinical Research Institute of Michigan 30795 23 Mile Rd. Suite 206 840071 Smith~xr22 Kenneth6i Principal Investigator MD Chesterfield 48047 Michigan UNITED STATES Burke Primary Care 103 Medical Heights Drive Morganton 840072 Gould Glenn Michael Sub-Investigator/Co-Investigator DO 28655 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Burke Primary Care 103 Medical Heights Drive Morganton 840072 Principal Investigator MD Smith~xr227i Stephen 28655 North Carolina UNITED STATES North Hills Med Research,Inc. 4351 Booth Calloway Suite 101 N Richland Hill 840073 Principal Investigator MD Gabriel~xr228 Johni 76180 Texas UNITED STATES North Hills Med Research,Inc. 4351 Booth Calloway Suite 101 N Richland Hill 840073 Lambert Joseph Sub-Investigator/Co-Investigator MD 76180 Texas UNITED STATES North Hills Med Research 4351 Booth Calloway Suite 101 N Richland Hill 840073 Magouirk Trisha Sub-Investigator/Co-Investigator MCRC 76180 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) North Hills Med Research 4351 Booth Calloway Suite 101 N Richland Hill 840073 Melliza Ted Sub-Investigator/Co-Investigator CRC 76180 Texas UNITED STATES North Hills Med Research 4351 Booth Calloway Suite 101 N Richland Hill 840073 Vela Matthew Sub-Investigator/Co-Investigator CRC 76180 Texas UNITED STATES Saviers Medical Group 246 E Scott St. Port Hueneme 840074 Custodio Ryan Sub-Investigator/Co-Investigator BS 93041 California UNITED STATES Saviers Medical Group 246 E Scott St. Port Hueneme 840074 Shapiro Zoya Sub-Investigator/Co-Investigator NP 93041 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Saviers Medical Group 246 E Scott St. Port Hueneme 840074 Principal Investigator MD Soroka~xr229 Eugenei 93041 California UNITED STATES Saviers Medical Group 246 E Scott St. Port Hueneme 840074 Steinberg Alon Sub-Investigator/Co-Investigator MD 93041 California UNITED STATES Northwest Endo Diabeted Research LLC 2101 S. Arlington Heights Arlington Heights 840075 Sapountzi Paraskevi Sub-Investigator/Co-Investigator MD 60005 Illinois UNITED STATES Northwest Endo Diabeted Research LLC 2101 S. Arlington Heights Road Suite 111 840075 So Daniel Sub-Investigator/Co-Investigator MD Arlington Heights 60005 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Northwest Endo Diabeted Research LLC 2101 S. Arlington Heights Arlington Heights 840075 Principal Investigator MD Soruco~xr230 Luisi 60005 Illinois UNITED STATES American Health Network of Indiana, LLC 5250 E US 36 Suite 645 840076 Benson Mark Sub-Investigator/Co-Investigator DO Avon 46123 Indiana UNITED STATES American Health Network of Indiana, LLC 5250 E US 36 Suite 645 840076 Cravens Carla Sub-Investigator/Co-Investigator CMA Avon 46123 Indiana UNITED STATES American Health Network of Indiana, LLC 5250 E US 36 Suite 645

840076 Schmoll Mary Sub-Investigator/Co-Investigator Nurse Practitioner Avon 46123 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) American Health Network of Indiana, LLC 5250 E US 36 Suite 645 840076 Smith Judy Sub-Investigator/Co-Investigator RN Avon 46123 Indiana UNITED STATES American Health Network of Indiana, LLC 5250 E US 36 Suite 645 840076 Stegemoller~xr231i Ronald Principal Investigator MD Avon 46123 Indiana UNITED STATES Larry D.Stonesifer, MD, Inc PS 34509 9th Ave. S Suite 200 & 203A 840077 Miller Marcia Sub-Investigator/Co-Investigator ARNP Federal Way 98003 Washington UNITED STATES Larry D.Stonesifer, MD, Inc PS 34509 9th Ave. S Suite 200 & 203A 840077 Stonesifer~xr232i Larry Principal Investigator MD Federal Way 98003 Washington UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Ducca Michelle Sub-Investigator/Co-Investigator CRC West Hills 91307 California UNITED STATES Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Fittingoff David Bruce Sub-Investigator/Co-Investigator MD West Hills 91307 California UNITED STATES Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Iqbal Mohammed Imran Sub-Investigator/Co-Investigator MD West Hills 91307 California UNITED STATES Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Sisneros Edith Sub-Investigator/Co-Investigator CRC West Hills 91307 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Streja~xr233 Dani Principal Investigator MD West Hills 91307 California UNITED STATES Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 Streja David Sub-Investigator/Co-Investigator DXA Technician West Hills 91307 California UNITED STATES Infosphere Clinical Research, Inc. 7345 Medical Center Dr. Suite 310 840078 White Stephen Sub-Investigator/Co-Investigator MD West Hills 91307 California UNITED STATES Protenium Clinical Research 1725 Chadwick Court Suite 200 840079 Camp Shana Sub-Investigator/Co-Investigator CCRC Hurst 76054 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Protenium Clinical Research 1725 Chadwick Court Suite 200 840079 Castro Cindy Sub-Investigator/Co-Investigator CRC Hurst 76054 Texas UNITED STATES Protenium Clinical Research 1725 Chadwick Court Suite 200 840079 Eizensmits Christina Sub-Investigator/Co-Investigator CCRP Hurst 76054 Texas UNITED STATES Protenium Clinical Research, LLC 1725 Chadwick Court Suite 200 840079 Strzinek~xr234i Robert Principal Investigator DO,PhD Hurst 76054 Texas UNITED STATES Protenium Clinical Research 1725 Chadwick Court Suite 200 840079 Terry Jessica Sub-Investigator/Co-Investigator CCRP Hurst 76054 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Protenium Clinical Research 1725 Chadwick Court Suite 200 840079 Toler Sara Sub-Investigator/Co-Investigator MSN Hurst 76054 Texas UNITED STATES Cedar Crosse Research Center 800 S Wells St Suite M15 Chicago 840080 Dugas Sr Jeffrey Sub-Investigator/Co-Investigator MD 60607 Illinois UNITED STATES Cedar Crosse Research Center 800 S Wells St Suite M15 Chicago 840080 Principal Investigator MD Sugimoto~xr235i Danny 60607 Illinois UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Carpio Gandahari Sub-Investigator/Co-Investigator MD New Orleans 70112 Louisiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tulane University 1430 Tulane Ave. SL 53 840081 Haggar Michelle Sub-Investigator/Co-Investigator MD New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Htun Wynn Sub-Investigator/Co-Investigator MD New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Katalenich Bonnie Sub-Investigator/Co-Investigator MPH New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Lovre Dragana Sub-Investigator/Co-Investigator MD New Orleans 70112 Louisiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tulane University 1430 Tulane Ave. SL 53 840081 Mcduffie Roberta Sub-Investigator/Co-Investigator ACNS New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 McKendall Lewis Chi Sub-Investigator/Co-Investigator RN New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Moreau Cynthia Sub-Investigator/Co-Investigator RN New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Stell Carol Sub-Investigator/Co-Investigator RN New Orleans 70112 Louisiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Tulane University 1430 Tulane Ave. SL 53 840081 Thethi~xr236 Tinai Principal Investigator MD New Orleans 70112 Louisiana UNITED STATES Tulane University 1430 Tulane Ave. SL 53 840081 Wang Aileen Sub-Investigator/Co-Investigator MD New Orleans 70112 Louisiana UNITED STATES Deacones Clinic Dowtown Research Institute 421 Chestnut St. Evansville 840082 Allababidi Hisham Sub-Investigator/Co-Investigator MD 47713 Indiana UNITED STATES Deacones Clinic Dowtown Research Institute 421 Chestnut St. Evansville 840082 Graves Mark Sub-Investigator/Co-Investigator MD 47713 Indiana UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Deacones Clinic Dowtown Research Institute 421 Chestnut St. Evansville 840082 Siage Youssef Sub-Investigator/Co-Investigator MD 47713 Indiana UNITED STATES Deacones Clinic Dowtown Research Institute 421 Chestnut St. Evansville 840082 Principal Investigator MD Thieneman~xr237i Andrew 47713 Indiana UNITED STATES Medical Investigations, Inc. 500 S University Ave. Suite 615 840084 Nimmo Teresa Sub-Investigator/Co-Investigator MD Little Rock 72205 Arkansas UNITED STATES Medical Investigations, Inc. 500 S University Ave. Suite 615 840084 Thrasher~xr238i James Principal Investigator MD Little Rock 72205 Arkansas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Midwest Institute for Clinical Research 8803 N Meridian St. Suite 200 840085 Toth~xr2 Phillip39i Principal Investigator MD Indianapolis 46260 Indiana UNITED STATES Midwest Institute for Clinical Research 8803 N Meridian St. Suite 200 840085 Weiser Don Sub-Investigator/Co-Investigator MD Indianapolis 46260 Indiana UNITED STATES St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Hersi Amina Sub-Investigator/Co-Investigator NP Mission Viejo 92691 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Mirza Carrie Sub-Investigator/Co-Investigator BS Mission Viejo 92691 California UNITED STATES St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Mulford Mim Sub-Investigator/Co-Investigator MD Mission Viejo 92691 California UNITED STATES St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Rivas Irma Sub-Investigator/Co-Investigator CRC Mission Viejo 92691 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Principal Investigator MD Tran~xr24 Neil0i Mission Viejo 92691 California UNITED STATES St Jude Hospital Yorba Linda d/b/a St. Joseph Heritage Healthcare 26800 Crown Valley Pkwy. Suite 230 840086 Wadell Chad Sub-Investigator/Co-Investigator MD Mission Viejo 92691 California UNITED STATES STVHCS Audie L. Murphy Memorial Vetenans Hospital 7400 Merton Minter Blvd 840087 Defronzo~xr241i Ralph Principal Investigator MD San Antonio 79229 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) STVHCS Audie L. Murphy Memorial Vetenans Hospital 7400 Merton Minter Blvd 840087 Koops Maureen Sub-Investigator/Co-Investigator MD San Antonio 79229 Texas UNITED STATES STVHCS Audie L. Murphy Memorial Vetenans Hospital 7400 Merton Minter Blvd 840087 Pinkson Sheila Sub-Investigator/Co-Investigator PA-C San Antonio 78229 Texas UNITED STATES STVHCS Audie L. Murphy Memorial Vetenans Hospital 7400 Merton Minter Blvd 840087 Tripathy~xr242i Devjit Principal Investigator MD, PhD San Antonio 78229 Texas UNITED STATES Docteurs Hospital at Renaissance 5525 Doctors Drive Edinburg 840088 Cordoba Kissee Michelle Lynn Sub-Investigator/Co-Investigator MD 78539 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Docteurs Hospital at Renaissance 5525 Doctors Drive Edinburg 840088 Principal Investigator MD Twahirwa~xr243i Marcel 78539 Texas UNITED STATES Grady Memorial Hospital (Grady Diabetes Clinic) 80 Jesse Hill, Jr. Dr SE Atlanta 840089 Oyedokun Festus Sub-Investigator/Co-Investigator MD 30303 Georgia UNITED STATES Grady Memorial Hospital (Grady Diabetes Clinic) 80 Jesse Hill, Jr. Dr SE Atlanta 840089 Pasquel Francisco Sub-Investigator/Co-Investigator MD 30303 Georgia UNITED STATES Grady Memorial Hospital (Grady Diabetes Clinic) 80 Jesse Hill, Jr. Dr SE Atlanta 840089 Robalino Gonzalo Sub-Investigator/Co-Investigator MD 30303 Georgia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Grady Memorial Hospital (Grady Diabetes Clinic) 80 Jesse Hill, Jr. Dr SE Atlanta 840089 Smiley Dawn Sub-Investigator/Co-Investigator MD 30303 Georgia UNITED STATES Grady Memorial Hospital (Grady Diabetes Clinic) 80 Jesse Hill, Jr. Dr SE Atlanta 840089 Principal Investigator MD Umpierrez~xr244i Guillermo 30303 Georgia UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Barnett Omar Sub-Investigator/Co-Investigator CRC Chino 91710 California UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Martinez Geraldine Sub-Investigator/Co-Investigator MSN Chino 91710 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Martinez Gilbert Sub-Investigator/Co-Investigator MD Chino 91710 California UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Martinez-Miss Salomon Sub-Investigator/Co-Investigator MSN, RN Chino 91710 California UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Moon Mia Sub-Investigator/Co-Investigator MD Chino 91710 California UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Soler Daniel Sub-Investigator/Co-Investigator CRC Chino 91710 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Catalina Research Institute LLC 14726 Ramona Ave Suite 100 840090 Unger~xr24 5Jeffreyi Principal Investigator MD Chino 91710 California UNITED STATES Catalina Research Institute LLC 14726 Ramona Ave Suite 110 840090 Valenzuela Louisito Sub-Investigator/Co-Investigator CRC Chino 91710 California UNITED STATES Borgess Research Institute 1521 Gull Rd. Clinical Research Kalamazoo 840091 Byers Joyce Sub-Investigator/Co-Investigator Coordinator 49048 Michigan UNITED STATES Borgess Research Institute 1521 Gull Rd. Kalamazoo 840091 Principal Investigator MD Greenberg~xr246i Craig 49048 Michigan UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Borgess Research Institute 1521 Gull Rd. Kalamazoo 840091 Rauch Ruth Sub-Investigator/Co-Investigator Registered Nurse 49048 Michigan UNITED STATES Borgess Research Institute 1521 Gull Rd. Kalamazoo 840091 Timpe Rebecca Sub-Investigator/Co-Investigator RN, CCRC 49048 Michigan UNITED STATES Borgess Research Institute 1521 Gull Rd. Kalamazoo 840091 Principal Investigator DO Valitutto~xr247i Michael 49048 Michigan UNITED STATES Eastern Viginia Medical School Strelitz Diabetes Center 855 West Brambleton Avenue 840092 Bourcier Matthew Sub-Investigator/Co-Investigator PA-C Norfolk 23150Virginia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Eastern Viginia Medical School Strelitz Diabetes Center 855 West Brambleton Avenue 840092 Casellini Carolina Sub-Investigator/Co-Investigator MD Norfolk 23150Virginia UNITED STATES Eastern Viginia Medical School Strelitz Diabetes Center 855 West Brambleton Avenue 840092 Principal Investigator MD Vinik~xr24 Aaron8i Norfolk 23150Virginia UNITED STATES Advanced Research Institute 6028 South Ridgeline Drive Suite 101 840093 Hibbert Spencer Sub-Investigator/Co-Investigator PA-C Ogden 84405 Utah UNITED STATES Advanced Research Institute 6028 South Ridgeline Drive Suite 101 840093 Wahlen~xr249 iJack Principal Investigator MD Ogden 84405 Utah UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Advanced Research Institute 6028 South Ridgeline Drive Suite 101 840093 Winkfield Jonathan Nicolas Sub-Investigator/Co-Investigator PA-C Ogden 84405 Utah UNITED STATES PMG Research of Knoxville 1200 Merchants Road Knoxville 840094 Chambers Robert Sub-Investigator/Co-Investigator MD 37912 Tennessee UNITED STATES PMG Research of Knoxville 1200 Merchants Road Knoxville 840094 Peters Todd Micheal Sub-Investigator/Co-Investigator MD 37912 Tennessee UNITED STATES PMG Research of Knoxville 1200 Merchants Road Knoxville 840094 Pritcher Gerald Sub-Investigator/Co-Investigator MD 37912 Tennessee UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Knoxville 1200 Merchants Road Licensed Practical Knoxville 840094 Puccio Kim Sub-Investigator/Co-Investigator Nurse 37912 Tennessee UNITED STATES PMG Research of Knoxville 1200 Merchants Road Knoxville 840094 Principal Investigator MD Wakefield~xr250i Paul 37912 Tennessee UNITED STATES PMG Research of Knoxville 1200 Merchants Road Knoxville 840094 West Michael Sub-Investigator/Co-Investigator MD 37912 Tennessee UNITED STATES Wilmington Medical Research 1202 Medical Center Dr. Wilmington 840095 Avots Erik Sub-Investigator/Co-Investigator CRC 28401 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Wilmington Medical Research 1202 Medical Center Dr. Wilmington 840095 Cannon Kevin Dougherty Sub-Investigator/Co-Investigator MD 28401 North Carolina UNITED STATES Wilmington Medical Research 1202 Medical Center Dr. Wilmington 840095 Daum Catherine Sub-Investigator/Co-Investigator MD 28401 North Carolina UNITED STATES Wilmington Medical Research 1202 Medical Center Dr. Wilmington 840095 Staub Jonathan Simon Sub-Investigator/Co-Investigator MD 28401 North Carolina UNITED STATES PMG Research of Wilmington, LLC 1202 Medical Center Dr. Wilmington 840095 Principal Investigator MD Webster~xr251i Brian 28401 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) SUNY Upstate Medical University Clinical Research Unit Insitute for Human Performance 505 Irving Avenue 840096 Izquierdo Roberto Sub-Investigator/Co-Investigator MD Syracuse 13210 New York UNITED STATES SUNY Upstate Medical University Clinical Research Unit Insitute for Human Performance 505 Irving Avenue 840096 Principal Investigator MD Weinstock~xr252i Ruth Syracuse 13210 New York UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Brown Summer Sub-Investigator/Co-Investigator RN 04210 Maine UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Dunham Victoria Sub-Investigator/Co-Investigator RN 04210 Maine UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Maine Research Associates 76 High Street Suite 204 840097 Freeman Deborah Sub-Investigator/Co-Investigator APRN 04210 Maine UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Heath Melissa Sub-Investigator/Co-Investigator RN 04210 Maine UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Peralta Maylene Claire Sub-Investigator/Co-Investigator MD 04210 Maine UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Stenberg Janet Sub-Investigator/Co-Investigator APRN 04210 Maine UNITED STATES Maine Research Associates 76 High Street Suite 204 840097 Trask Laura Sub-Investigator/Co-Investigator MD 04210 Maine UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Maine Research Associates 76 High Street Suite 204 840097 Weiss~xr253 Roberti Principal Investigator MD 04210 Maine UNITED STATES Baptist Diabetes Associates N. Kendall Drive Ste 80 840098 Cohen Martin Sub-Investigator/Co-Investigator MD Miami 33156Florida UNITED STATES Baptist Diabetes Associates N. Kendall Drive, Ste 80 840098 Estrada-Alberti Giselle Sub-Investigator/Co-Investigator CRC Miami 33156-Florida UNITED STATES Baptist Diabetes Associates N. Kendall Drive, Ste 80 840098 Llobet Mario Sub-Investigator/Co-Investigator CCRC Miami 33156Florida UNITED STATES Baptist Diabetes Associates 7867 N. Kendall Drive, Ste 80 840098 Rothberg Martin Sub-Investigator/Co-Investigator MD Miami 33156Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Baptist Diabetes Associates 7867 N. Kendall Drive , Ste 80 840098 Weissman~xr254i Peter Principal Investigator MD Miami 33156Florida UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Dillard Cynthia Sub-Investigator/Co-Investigator RD Winston-Salem 27103 North Carolina UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Holmes Robert John Sub-Investigator/Co-Investigator MD Winston-Salem 27103 North Carolina UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Ingram Patsy Clayton Sub-Investigator/Co-Investigator LPN Winston-Salem 27103 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Smith Brian Stanley Sub-Investigator/Co-Investigator MD Winston-Salem 27103 North Carolina UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Speece Jessica Sub-Investigator/Co-Investigator BS Winston-Salem 27103 North Carolina UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 West Sandra Sub-Investigator/Co-Investigator CRC Winston-Salem 27103 North Carolina UNITED STATES PMG Research of Winston-Salem 1901 S Hawthorne Rd. Suite 306 840099 Wilson~xr255 Jonathani Principal Investigator DO Winston-Salem 27103 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Demicco Michael Sub-Investigator/Co-Investigator MD 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Haggag Amina Sub-Investigator/Co-Investigator MD 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Kuettel Kevin Sub-Investigator/Co-Investigator MD 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Lee Elizabeth Sub-Investigator/Co-Investigator PhD 92801 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Parker Anna Sub-Investigator/Co-Investigator CRC 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Ramirez Karina Sub-Investigator/Co-Investigator CRC 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Riff Dennis Sub-Investigator/Co-Investigator MD 92801 California UNITED STATES Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Rojas Martha Sub-Investigator/Co-Investigator CRC 92801 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Anaheim Clinical Trials 1085 N. Harbor Blvd. Anaheim 840100 Principal Investigator MD Winkle~xr256 Peteri 92801 California UNITED STATES Facey Medical Foundation 11333 Sepulveda Blvd. Mission Hills 840101 Beaman Melissa Sub-Investigator/Co-Investigator RNP 91345 California UNITED STATES Facey Medical Foundation 11333 Sepulveda Blvd. Mission Hills 840101 Principal Investigator MD Chambers~xr257i Joseph 91345 California UNITED STATES Facey Medical Foundation 11333 Sepulveda Blvd. Mission Hills 840101 Dang Andy Sub-Investigator/Co-Investigator MD 91345 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Facey Medical Foundation 11333 Sepulveda Blvd. Mission Hills 840101 Kim Grace Sub-Investigator/Co-Investigator MD 91345 California UNITED STATES Facey Medical Foundation 11333 Sepulveda Blvd. Mission Hills 840101 Wilson Lou Ellen. Sub-Investigator/Co-Investigator MD 91345 California UNITED STATES Rainier Clinical Research Center 723 SW 10th St. Suite 100 840102 Brazg~xr258 Ronaldi Principal Investigator MD Renton 98057 Washington UNITED STATES Rainier Clinical Research Center 723 SW 10th St. Suite 100 840102 Klaff Leslie Joseph Sub-Investigator/Co-Investigator MD Renton 98057 Washington UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Rainier Clinical Research Center 723 SW 10th St. Suite 100 840102 Sussman Allen Micheal Sub-Investigator/Co-Investigator MD Renton 98057 Washington UNITED STATES Williamette Valley Clinical Studies 890 River Road Eugene 840103 Bailey Douglas Sub-Investigator/Co-Investigator MD 97404 Oregon UNITED STATES Williamette Valley Clinical Studies 890 River Road Eugene 840103 Principal Investigator MD Buchanan~xr259i Patricia 97404 Oregon UNITED STATES Williamette Valley Clinical Studies 890 River Road Eugene 840103 Debroekert Dirk Sub-Investigator/Co-Investigator PA-C 97404 Oregon UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Williamette Valley Clinical Studies 890 River Road Eugene 840103 Vancleave Brady Sub-Investigator/Co-Investigator CCRC 97404 Oregon UNITED STATES Meridien Research - Bradenton 5700 SR 64 East Bradenton 840104 Principal Investigator MD Chaykin~xr260i Louis 34208 Florida UNITED STATES Meridien Research - Bradenton 5700 SR 64 East Bradenton 840104 Dowell Michelle Sub-Investigator/Co-Investigator BS 34208 Florida UNITED STATES Meridien Research - Bradenton 5700 SR 64 East Bradenton 840104 Hendrick Mary Sub-Investigator/Co-Investigator RN 34208 Florida UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Meridien Research - Bradenton 5700 SR 64 East Bradenton 840104 Mallitz Michelle Sub-Investigator/Co-Investigator MD 34208 Florida UNITED STATES Rocky Mountain Diabetes and Osteoporosis Center 3910 Washington Pkwy. 840108 Coughenour Tiffany Sub-Investigator/Co-Investigator PA-C Idaho Falls 83404-7596 Idaho UNITED STATES Rocky Mountain Diabetes and Osteoporosis Center 3910 Washington Pkwy. 840108 Liljenquist David Sub-Investigator/Co-Investigator MD Idaho Falls 83404-7596 Idaho UNITED STATES Rocky Mountain Diabetes and Osteoporosis Center 3910 Washington Pkwy. 840108 Vance~xr26 1iCarl Principal Investigator MD Idaho Falls 83404-7596 Idaho UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Rocky Mountain Diabetes and Osteoporosis Center 3910 Washington Pkwy. 840108 Williams Jonathan Sub-Investigator/Co-Investigator FNP-C Idaho Falls 83404-7596 Idaho UNITED STATES Desert Endocrinology 2415 W Horizon Ridge Pkwy Henderson 840109 Amirjalali Violet Sub-Investigator/Co-Investigator PA-C 89052 Nevada UNITED STATES Desert Endocrinology 2415 W Horizon Ridge Pkwy Henderson 840109 Principal Investigator MD Litchfield~xr262i William 89052 Nevada UNITED STATES Desert Endocrinology 2415 W Horizon Ridge Pkwy Henderson 840109 Walker Tomas Sub-Investigator/Co-Investigator DNP 89052 Nevada UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Salisbury 410 Mocksville Ave. Salisbury 840110 Farrington, Jr. Cecil Sub-Investigator/Co-Investigator MD 28144 North Carolina UNITED STATES PMG Research of Salisbury 410 Mocksville Ave. Salisbury 840110 Fox Alana Sub-Investigator/Co-Investigator CCRC 28144 North Carolina UNITED STATES PMG Research of Salisbury 401 Mocksville Ave. Suite 200 840110 Haywood Ashley Sub-Investigator/Co-Investigator CCRC Salisbury 28144 North Carolina UNITED STATES PMG Research of Salisbury, LLC. 410 Mocksville Ave. Salisbury 840110 Principal Investigator MD Mcneill~xr263 Roberti 28144 North Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Salisbury 410 Mocksville Ave. Salisbury 840110 Pittman Amy Sub-Investigator/Co-Investigator CRC 28144 North Carolina UNITED STATES Protenium Clinical Research , LLC 221 W Colorado Blvd. Suite 843 840111 Camp Shana Sub-Investigator/Co-Investigator CCRC Dallas 75208 Texas UNITED STATES Protenium Clinical Research , LLC 221 W Colorado Blvd. Suite943 840111 Fordan~xr264i Steve Principal Investigator MD Dallas 75208 Texas UNITED STATES Protenium Clinical Research , LLC 221 W Colorado Blvd. Suite 943 840111 Joslin Brenda Sub-Investigator/Co-Investigator CRC Dallas 75208 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Protenium Clinical Research , LLC 221 W Colorado Blvd. Suite 943 840111 Robbins D'Lorah Louise Sub-Investigator/Co-Investigator PA-C Dallas 75208 Texas UNITED STATES PMG Research of Bristol 350 Steeles Road. Bristol 840112 Claybrook Phillip Harry Sub-Investigator/Co-Investigator MD 37620 Tennessee UNITED STATES PMG Research of Bristol 350 Steeles Road. Bristol 840112 Dye Amy Sub-Investigator/Co-Investigator CCRC 37620 Tennessee UNITED STATES PMG Research of Bristol 350 Steeles Road. Bristol 840112 Principal Investigator MD Grunstra~xr265i Bernard 37620 Tennessee UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) PMG Research of Bristol 350 Steeles Road. Bristol 840112 Morrell Kathy Sub-Investigator/Co-Investigator LPN 37620 Tennessee UNITED STATES PMG Research of Bristol 350 Steeles Road. Bristol 840112 Gilmer Olds Shelby Sub-Investigator/Co-Investigator MD 37620 Tennessee UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Principal Investigator MD Ahmann~xr266i Andrew 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Bogan Christopher Sub-Investigator/Co-Investigator MPH 97239 Oregon UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Castle Jessica Sub-Investigator/Co-Investigator MD 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Cox Jennifer Sub-Investigator/Co-Investigator MASc 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Defrang Donald Sub-Investigator/Co-Investigator BS 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Fitch Rebecca Sub-Investigator/Co-Investigator BS 97239 Oregon UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Hanavan Kathryn Sub-Investigator/Co-Investigator RN 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Joarder Farahnaz Sub-Investigator/Co-Investigator MD 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Klopfenstein Bethany Sub-Investigator/Co-Investigator MD 97239 Oregon UNITED STATES Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 White Bradley Sub-Investigator/Co-Investigator BS 97239 Oregon UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Oregon Health and Sciences University 3181 SW Sam Jackson Park Rd. Portland 840113 Wollam Bethany Sub-Investigator/Co-Investigator CCRP 97239 Oregon UNITED STATES Regional Medical Clinic Endocrinology 640 Flormann St. Rapid City 840114 Borgwardt Trista Sub-Investigator/Co-Investigator RN 57701 South Dakota UNITED STATES Regional Medical Clinic Endocrinology 640 Flormann St. Rapid City 840114 Deraad Linda Sub-Investigator/Co-Investigator RN 57701 South Dakota UNITED STATES Regional Medical Clinic Endocrinology 735 Meade Street

840114 Edelen Rachel Sub-Investigator/Co-Investigator MD Rapid City 57701 South Dakota UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Regional Medical Clinic Endocrinology 640 Flormann St. Rapid City 840114 Kieffer Tosha Sub-Investigator/Co-Investigator RN 57701 South Dakota UNITED STATES Regional Medical Clinic Endocrinology 735 Meade Street Rapid City 840114 Principal Investigator DO Repas~xr26 7iThomas 57701 South Dakota UNITED STATES Regional Medical Clinic Endocrinology 735 Meade Street Rapid City 840114 Wasson Michelle Sub-Investigator/Co-Investigator CRC 57701 South Dakota UNITED STATES Salem VA Medical Center 1970 Roanoke Blvd. Salem 840115 Cohen Shannon Sub-Investigator/Co-Investigator PhD 24153 Virginia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Salem VA Medical Center 1970 Roanoke Blvd. Salem 840115 Gullapalli Dakshinamurty Sub-Investigator/Co-Investigator MD 24153 Virginia UNITED STATES Salem VA Medical Center 1970 Roanoke Blvd. Salem 840115 Principal Investigator MD Iranmanesh~xr268i Ali 24153 Virginia UNITED STATES Salem VA Medical Center 1970 Roanoke Blvd. Salem 840115 Iranmanesh Ashraf Sub-Investigator/Co-Investigator PhD 24153 Virginia UNITED STATES Chicago Clinical Research Institute Inc. 2555 S Martin Luther King Dr. 2nd Fl. 840116 Ahmed Azazuddin Sub-Investigator/Co-Investigator MD Chicago 60616 Illinois UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Chicago Clinical Research Institute Inc. 2555 S Martin Luther King Dr. 2nd Fl. 840116 Kenney Barbara Sub-Investigator/Co-Investigator NP-C Chicago 60616 Illinois UNITED STATES Chicago Clinical Research Institute Inc. 2555 S Martin Luther King Dr. 2nd Fl. 840116 Kuehl Ann Sub-Investigator/Co-Investigator PA-C Chicago 60616 Illinois UNITED STATES Chicago Clinical Research Institute Inc. 2555 S Martin Luther King Dr. 2nd Fl. 840116 Levinson~xr269i Dennis Principal Investigator MD Chicago 60616 Illinois UNITED STATES Diabetes and Thyroid Center of Fort Worth 7801 Oakmont Blvd Suite 101 840118 Bajaj Chris Sub-Investigator/Co-Investigator DO Fort Worth 76132 Texas UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Diabetes and Thyroid Center of Fort Worth 7801 Oakmont Blvd Suite 101 840118 Crumm Jennifer Sub-Investigator/Co-Investigator PA-C Fort Worth 76132 Texas UNITED STATES Diabetes and Thyroid Center of Fort Worth 7801 Oakmont Blvd Suite 101 840118 Tan~xr27 Anjanette0i Principal Investigator MD Fort Worth 76132 Texas UNITED STATES North Georgia Clinical Research 1192 Buckhead Crossing Suite A 840119 Skardasis Michael Georges Sub-Investigator/Co-Investigator MD Woodstock 30189 Georgia UNITED STATES North Georgia Clinical Research 1192 Buckhead Crossing Suite A 840119 Wieskopf~xr271i Bram Principal Investigator MD Woodstock 30189 Georgia UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) St. Joseph Heritage Healthcare 510 Superior Avenue Suite 200B-F 840120 Creamer Maily Sub-Investigator/Co-Investigator DO Newport beach 92663 California UNITED STATES St. Joseph Heritage Healthcare 510 Superior Avenue Suite 200B-F 840120 Nadeau~xr272i Daniel Principal Investigator MD Newport beach 92663 California UNITED STATES Arvind Mehta, MD 2785 Pacific Avenue Ste A Long Beach 840121 Principal Investigator MD Mehta~xr27 3Arvindi 90806 California UNITED STATES Arvind Mehta, MD 2785 Pacific Avenue Ste A Long Beach 840121 Patel Gnyandev Sub-Investigator/Co-Investigator MD 90806 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Precision Trials 3815 E Bell Rd. Suite 4200B 840122 Drury Michael Scott Sub-Investigator/Co-Investigator MD Phoenix 85032 Arizona UNITED STATES Precision Trials 3815 E Bell Rd. Suite 4200B 840122 Kelly~xr274i Richard Principal Investigator MD Phoenix 85032 Arizona UNITED STATES Precision Trials 3815 E Bell Rd. Suite 4200B 840122 Young Peter Si-Hai Sub-Investigator/Co-Investigator MD Phoenix 85032 Arizona UNITED STATES ProMetrix Clinical Studies 25 Kilmer Dr., Bldg 3 Suite 215 840123 Donner Pamela Sub-Investigator/Co-Investigator RPA-C Morganville 07751 New Jersey UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) ProMetrix Clinical Studies 25 Kilmer Dr., Bldg 3 Suite 215 840123 Kroll~xr27 Spencer5i Principal Investigator MD Morganville 07719 New Jersey UNITED STATES ProMetrix Clinical Studies 25 Kilmer Dr., Bldg 3 Suite 215 840123 Messinger Jason Sub-Investigator/Co-Investigator MS Morganville 07719 New Jersey UNITED STATES ProMetrix Clinical Studies 25 Kilmer Dr., Bldg 3 Suite 215 840123 Passes Philip Sub-Investigator/Co-Investigator DO Morganville 07719 New Jersey UNITED STATES ProMetrix Clinical Studies 25 Kilmer Dr., Bldg 3 Suite 215 840123 Weissman Lawrence Sub-Investigator/Co-Investigator MD Morganville 07719 New Jersey UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Dominion Medical Associates 304 Leigh St. Richmond 840125 Covington Damian Sub-Investigator/Co-Investigator MD 23219 Virginia UNITED STATES Dominion Medical Associates 304 Leigh St. Richmond 840125 Principal Investigator MD Jackson~xr276i Richard 23219 Virginia UNITED STATES Dominion Medical Associates 304 Leigh St. Richmond 840125 Nelson Claretha Sub-Investigator/Co-Investigator MA 23219 Virginia UNITED STATES Downtown LA Research Center, Inc 1125 W. 6th Street Los Angeles 840126 Alvarado Regina Sub-Investigator/Co-Investigator MA 90017 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Downtown LA Research Center, Inc 1125 W. 6th Street Los Angeles 840126 Cisneros Claudia Sub-Investigator/Co-Investigator MA 90017 California UNITED STATES Downtown LA Research Center, Inc 1125 W. 6th Street Los Angeles 840126 Principal Investigator DO Nadkarni~xr277i Salil 90017 California UNITED STATES Downtown LA Research Center, Inc 1125 W. 6th Street Los Angeles 840126 Orellana Jose Sub-Investigator/Co-Investigator CRC 90017 California UNITED STATES Downtown LA Research Center, Inc 1125 W. 6th Street Los Angeles 840126 Tizon Lorenzo Sub-Investigator/Co-Investigator MD 90017 California UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Bates Daniel Sub-Investigator/Co-Investigator MD Charleston 29407 South Carolina UNITED STATES Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Crisp Melissa Sub-Investigator/Co-Investigator BS Charleston 29407 South Carolina UNITED STATES Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Hurley~xr27 8Donaldi Principal Investigator DO Charleston 29407 South Carolina UNITED STATES Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Kinney Laura Lee Sub-Investigator/Co-Investigator MD Charleston 29407 South Carolina UNITED STATES

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Study Center Professional Investigator last name and first name* Role in the Investigation Institutional Affiliation(s) No. Degree(s) Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Reinhardt Tatiana Sub-Investigator/Co-Investigator BS Charleston 29407 South Carolina UNITED STATES Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Fyall Shalyn Sub-Investigator/Co-Investigator MA Charleston 29407 South Carolina UNITED STATES Medical Research South 1481 Tobias Gadson Blvd. Suite 2 840127 Perry Shannon Sub-Investigator/Co-Investigator CRC Charleston 29407 South Carolina UNITED STATES