MDMA, “Ecstasy”)
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American Civil Liberties Union
WASHINGTON LEGISLATIVE OFFICE March 19, 2012 Honorable Patti B. Saris, Chair United States Sentencing Commission One Columbus Circle, N.E. Suite 2-500, South Lobby Washington, D.C. 2002-8002 Re: ACLU Comments on Proposed Amendments to Sentencing Guidelines, Policy Statements, and Commentary due on March 19, 2012 AMERICAN CIVIL LIBERTIES UNION WASHINGTON Dear Judge Saris: LEGISLATIVE OFFICE 915 15th STREET, NW, 6 TH FL WASHINGTON, DC 20005 With this letter the American Civil Liberties Union (“ACLU”) provides T/202.544.1681 commentary on the Amendments to the U.S. Sentencing Guidelines F/202.546.0738 WWW.ACLU.ORG (“Guidelines”) proposed by the Commission on January 19, 2012. The American Civil Liberties Union is a non-partisan organization with more than LAURA W. MURPHY DIRECTOR half a million members, countless additional activists and supporters, and 53 NATIONAL OFFICE affiliates nationwide dedicated to the principles of liberty, equality, and justice 125 BROAD STREET, 18 TH FL. embodied in our Constitution and our civil rights laws. NEW YORK, NY 10004-2400 T/212.549.2500 These comments address four issues that the Commission has asked for OFFICERS AND DIRECTORS SUSAN N. HERMAN public comment on by March 19, 2012. First, the ACLU encourages the PRESIDENT Commission to reject the adoption of the 500:1 MDMA marijuana equivalency ANTHONY D. ROMERO ratio for N-Benzylpiperazine, also known as BZP, (BZP) and make substantial EXECUTIVE DIRECTOR downward revisions to the MDMA marijuana equivalency ratio. Also, we urge ROBERT REMAR the Commission to respect the principles of proportionality and due process in TREASURER deciding how and whether to amend the Guideline for unlawfully entering or remaining in the country. -
The Medical Management of Depression
The new england journal of medicine review article drug therapy The Medical Management of Depression J. John Mann, M.D. ecurrent episodes of major depression, which is a common From the Department of Neuroscience, and serious illness, are called major depressive disorder; depressive episodes New York State Psychiatric Institute– r Columbia University College of Physicians that occur in conjunction with manic episodes are called bipolar disorder. and Surgeons, New York. Address reprint Major depressive disorder accounts for 4.4 percent of the total overall global disease requests to Dr. Mann at the Department of burden, a contribution similar to that of ischemic heart disease or diarrheal diseases.1 Neuroscience, New York State Psychiatric 2 Institute, 1051 Riverside Dr., Box 42, New The prevalence of major depressive disorder in the United States is 5.4 to 8.9 percent York, NY 10032, or at [email protected]. and of bipolar disorder, 1.7 to 3.7 percent.3 Major depression affects 5 to 13 percent of medical outpatients,4 yet is often undiagnosed and untreated.5,6 Moreover, it is often N Engl J Med 2005;353:1819-34. undertreated when correctly diagnosed.6 Copyright © 2005 Massachusetts Medical Society. The demographics of depression are impressive. Among persons both with major depressive disorder and bipolar disorder, 75 to 85 percent have recurrent episodes.7,8 In addition, 10 to 30 percent of persons with a major depressive episode recover incom- pletely and have persistent, residual depressive symptoms, or dysthymia, a disorder with symptoms -
Ecstasy Or Molly (MDMA) (Canadian Drug Summary)
www.ccsa.ca • www.ccdus.ca November 2017 Canadian Drug Summary Ecstasy or Molly (MDMA) Key Points Ecstasy and molly are street names for pills or tablets that are assumed to contain the active ingredient 3,4-methylenedioxy-N-methamphetamine (MDMA). Although most people consuming ecstasy or molly expect the main psychoactive ingredient to be MDMA, pills, capsules and powder sold as ecstasy or molly frequently contain other ingredients (such as synthetic cathinones or other adulterants) in addition to MDMA and sometimes contain no MDMA at all. The prevalence of Canadians aged 15 and older reporting past-year ecstasy use is less than 1%. 1 in 25 Canadian youth in grades 10–12 have reported using ecstasy in the past 12 months. Introduction Ecstasy and molly are street names for pills, capsules or powder assumed to contain MDMA (3,4- methylenedioxy-N-methamphetamine), a synthetically derived chemical that is used recreationally as a party drug. Pills are typically coloured and stamped with a logo. These drugs are made in illegal laboratories, often with a number of different chemicals, so they might not contain MDMA or contain MDMA in amounts that vary significantly from batch to batch. Other active ingredients found in tablets sold as ecstasy or molly in Canada in 2016–2017 include synthetic cathinones or “bath salts” such as ethylone, methylenedioxyamphetamine (MDA) and its precursor methylenedioxyphenylpropionamide (MMDPPA). Other adulterants reported were caffeine, procaine, methylsulfonylmethane (MSA)and methamphetamine.1 In 2011–2012, paramethoxymethamphetamine (PMMA) was present in pills sold as ecstasy in Canada. This adulteration resulted in the deaths of 27 individuals in Alberta and British Columbia over an 11-month period.2 Effects of Ecstasy Use The effects of ecstasy are directly linked to the active ingredients in the pill. -
Polymorphic Regions of the Estrogen Receptor, Androgen Receptor and Serotonin Transporter Genes and Their Association with Mood Variability in Young Women
Lakehead University Knowledge Commons,http://knowledgecommons.lakeheadu.ca Electronic Theses and Dissertations Retrospective theses 2006 Polymorphic regions of the estrogen receptor, androgen receptor and serotonin transporter genes and their association with mood variability in young women Richards, Meghan A. http://knowledgecommons.lakeheadu.ca/handle/2453/3361 Downloaded from Lakehead University, KnowledgeCommons Polymorphic Regions 1 Ruimmg head: GENETIC POLYMORPHISMS AND MOOD Polymorphic Regions of the Estrogen Receptor, Androgen Receptor and Serotonin Transporter Genes and their Association with Mood Variability in Young Women Meghan A. Richards M.A. Thesis Lakehead University Supervisor: Dr. Kirsten Oinonen copyright © Meghan Richards, 2006 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Library and Bibliothèque et 1^1 Archives Canada Archives Canada Published Heritage Direction du Branch Patrimoine de l'édition 395 Wellington Street 395, rue Wellington Ottawa ON K1A 0N4 Ottawa ON K1A 0N4 Canada Canada Your file Votre référence ISBN: 978-0-494-21539-5 Our file Notre référence ISBN: 978-0-494-21539-5 NOTICE: AVIS: The author has granted a non L'auteur a accordé une licence non exclusive exclusive license allowing Library permettant à la Bibliothèque et Archives and Archives Canada to reproduce,Canada de reproduire, publier, archiver, publish, archive, preserve, conserve,sauvegarder, conserver, transmettre au public communicate to the public by par télécommunication ou par l'Internet, prêter, telecommunication or on the Internet,distribuer et vendre des thèses partout dans loan, distribute and sell theses le monde, à des fins commerciales ou autres, worldwide, for commercial or non sur support microforme, papier, électronique commercial purposes, in microform,et/ou autres formats. -
Synergistic Discriminative Effect of LSD and MDMA
European Journal of Pharmacology 341Ž. 1998 131±134 Short Communication `Candyflipping': Synergistic discriminative effect of LSD and MDMA Martin D. Schechter ) Department of Pharmacology, Northeastern Ohio UniÕersities College of Medicine, P.O. Box 95, Rootstown, OH 44272-0095, USA Received 27 October 1997; accepted 28 October 1997 Abstract The co-administration of D-lysergic acid diethylamideŽ. LSD; `Acid' and 3,4-methylenedioxymethamphetamine Ž MDMA; `Ecstasy'; `XTC'. , has reached a prevalence that has allowed for the street terminology `candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mgrkg MDMA and were, subsequently, tested with doses of MDMAŽ.Ž 0.15 mgrkg or LSD 0.04 mgrkg. that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect. q 1998 Elsevier Science B.V. Keywords: Drug discrimination; MDMA; LSD Ž.D-lysergic acid diethylamide ; Candyflipping; Synergism; Ž. Rat 1. Introduction will be citedŽ. http:rrwww sites . This information may be seen to be of suspicious scientific merit yet this source `Candyflipping' is the `street' term for the co-adminis- may allow for extensive subjective and unsolicited infor- tration of D-lysergic acid diethylamideŽ. LSD and 3,4- mation to permit insights into the popular trends in the methylenedioxymethamphetamineŽ. MDMA . The scien- drug culture. Having stated these caveats, the co-adminis- tific literature on the effects of using these two Drug tration of MDMA with LSD has been suggested to ``go Enforcement AgencyŽ. -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Human 5-HT Transporter Availability Predicts Amygdala Reactivityin Vivo
The Journal of Neuroscience, August 22, 2007 • 27(34):9233–9237 • 9233 Brief Communications Human 5-HT Transporter Availability Predicts Amygdala Reactivity In Vivo Rebecca A. Rhodes,1 Naga Venkatesha Murthy,1,3 M. Alex Dresner,2 Sudhakar Selvaraj,1,4 Nikolaos Stavrakakis,1 Syed Babar,5 Philip J. Cowen,4 and Paul M. Grasby1 1Psychiatry Group, 2Imaging Sciences Department, Medical Research Council (MRC) Clinical Sciences Centre, and 3Experimental Medicine, Psychiatry Clinical Pharmaceology Discovery Medicine, GlaxoSmithKline Clinical Imaging Centre, Imperial College London, London W12 0NN, United Kingdom, 4Department of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom, and 5Radiology Department, Hammersmith Hospital, London W12 0HS, United Kingdom The amygdala plays a central role in fear conditioning, emotional processing, and memory modulation. A postulated key component of the neurochemical regulation of amygdala function is the neurotransmitter 5-hydroxytryptamine (5-HT), and synaptic levels of 5-HT in the amygdala and elsewhere are critically regulated by the 5-HT transporter (5-HTT). The aim of this study was to directly examine the relationship between 5-HTT availability and amygdala activity using multimodal [positron emission tomography (PET) and functional magnetic resonance imaging (fMRI)] imaging measures in the same individuals. Healthy male volunteers who had previously undergone an[ 11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile([ 11C]-DASB)PETscantodetermine5-HTTavailabilitycom- pleted an fMRI emotion recognition task. [ 11C]-DASB binding potential values were calculated for the amygdala using arterial input function and linear graphical (Logan) analysis. fMRI was performed on a 3T Philips Intera scanner, and data were analyzed using SPM2 (Wellcome Department Imaging Neuroscience, University College London). -
Ecstasy Or Molly, Is a Synthetic Psychoactive Drug
DRUG ENFORCEMENT ADMINISTRATION THE FACTS ABOUT MDMA Ecstasy &Molly DEA PHOTO What is it? MDMA, (3,4-methylenedioxy- methamphetamine), known as Ecstasy or Molly, is a synthetic psychoactive drug. Ecstasy is the pill form of MDMA. Molly is the slang for “molecular” that refers to the powder or crystal form of MDMA. Molly is often mixed with other drugs and substances and is not pure MDMA or safe to use. How is it used? MDMA or Ecstasy is taken orally in pill or tablet form. These pills can be in different colors with images on them. Molly is taken in a gel capsule or snorted. What does MDMA do to the body and mind? • As a stimulant drug, it increases heart rate and blood pressure. Users may experience muscle tension, involuntary teeth clenching, nausea, blurred vision, faintness, chills, or sweating • It produces feelings of increased energy, euphoria, emotional warmth, empathy, and distortions in sensory and time perception. • Feelings of sadness, anxiety, depression and memory difficulties are other effects. • It can seriously deplete serotonin levels in the brain, causing confusion and sleep problems. Did you know? • DEA has labeled MDMA as a Schedule I drug, meaning its abuse potential is high and it has no approved medical use. It is illegal in the U.S. • In high doses, MDMA can affect the body’s ability to regulate temperature, which can lead to serious health complications and possible death. • Teens are using less MDMA. Teens decreased their past year use of MDMA from 1.9% in 2010 to 1.2% of teens using 2012. -
Contents I. Central Nervous System Diseases Ii
CONTENTS CONTRIBUTORS xi PREFACE xiii CORRIGENDUM xv I. CENTRAL NERVOUS SYSTEM DISEASES Section Editor: David Wustrow, Pfizer Global Research & Development, Ann Arbor, Michigan 1. Neuronal Nicotinic Acetylcholine Receptor Modulators: Recent Advances and Therapeutic Potential 3 Scott R. Breining, Anatoly A. Mazurov and Craig H. Miller, Targacept, Inc., 200 East First Street, Suite 300, Winston-Salem, NC 27101 2. Recent Advances in Selective Serotonergic Agents 17 Wayne E. Childers, Jr. and Albert J. Robichaud, Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 3. BACE Inhibitors for the Treatment of Alzheimer’s Disease 35 Ellen W. Baxter and Allen B. Reitz, Johnson & Johnson Pharmaceutical Research and Development LLC, Spring House, PA 19477-0776 4. Positron Emission Tomography Agents for Central Nervous System Drug Development Applications 49 N. Scott Masona and Chester A. Mathisa,b,c, aDepartments of Radiology, bPharmacology and cPharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA II. CARDIOVASCULAR AND METABOLIC DISEASES Section Editor: Andrew Stamford, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 5. Emerging Topics in Atherosclerosis: HDL Raising Therapies 71 Peter J. Sinclair, Merck Research Laboratories, Rahway, NJ 07065, USA v vi Contents 6. Small Molecule Anticoagulant/Antithrombotic Agents 85 Robert M. Scarborough, Anjali Pandey and Xiaoming Zhang, Portola Pharmaceuticals, Inc., 270 East Grand Ave., Suite 22, South San Francisco, CA 94080, USA 7. CB1 Cannabinoid Receptor Antagonists 103 Francis Barth, Sanofi-aventis, 371 rue du Professeur Blayac 34184 Montpellier Cedex 04, France 8. Melanin-Concentrating Hormone as a Therapeutic Target 119 Mark D. McBriar and Timothy J. Kowalski, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 9. -
MDMA) Cause Selective Ablation of Serotonergic Axon Terminals in Forebrain: Lmmunocytochemical Evidence for Neurotoxicity
The Journal of Neuroscience, August 1988, 8(8): 2788-2803 Methylenedioxyamphetamine (MDA) and Methylenedioxymetham- phetamine (MDMA) Cause Selective Ablation of Serotonergic Axon Terminals in Forebrain: lmmunocytochemical Evidence for Neurotoxicity E. O’Hearn,” G. Battaglia, lab E. B. De Souza,’ M. J. Kuhar,’ and M. E. Molliver Departments of Neuroscience, and Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and ‘Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224 The psychotropic amphetamine derivatives 3,4-methylene- The synthetic amphetamine derivatives 3,4-methylenedioxy- dioxyamphetamine (MDA) and 3,4-methylenedioxymetham- amphetamine (MDA) and 3,4-methylenedioxymethamphet- phetamine (MDMA) have been used for recreational and amine (MDMA) are potent mood-altering drugs that have at- therapeutic purposes in man. In rats, these drugs cause large tained public interest (Seymour, 1986) due to their widespread, reductions in brain levels of serotonin (5HT). This study self-administration by young adults (e.g., Klein, 1985). These employs immunocytochemistry to characterize the neuro- drugs have also been proposed for medical use in psychotherapy toxic effects of these compounds upon monoaminergic neu- because they produce augmentation of mood and enhanced in- rons in the rat brain. Two weeks after systemic administra- sight (Naranjo et al., 1967; Yensen et al., 1976; Di Leo, 198 1; tion of MDA or MDMA (20 mg/kg, s.c., twice daily for 4 d), Greer and Tolbert, 1986; Grinspoon and Bakalar, 1986). How- there is profound loss of serotonergic (5HT) axons through- ever, concern has been raised about the safety of these com- out the forebrain; catecholamine axons are completely pounds based on evidence that they may be toxic to brain seroto- spared. -
Current Topics in Behavioral Neurosciences
Current Topics in Behavioral Neurosciences Series Editors Mark A. Geyer, La Jolla, CA, USA Bart A. Ellenbroek, Wellington, New Zealand Charles A. Marsden, Nottingham, UK For further volumes: http://www.springer.com/series/7854 About this Series Current Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats. With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on ‘‘translational medicine’’ and cutting-edge technologies. Preclinical and clinical trials for the development of new diagostics and therapeutics as well as prevention efforts are covered whenever possible. Cameron S. Carter • Jeffrey W. Dalley Editors Brain Imaging in Behavioral Neuroscience 123 Editors Cameron S. Carter Jeffrey W. Dalley Imaging Research Center Department of Experimental Psychology Center for Neuroscience University of Cambridge University of California at Davis Downing Site Sacramento, CA 95817 Cambridge CB2 3EB USA UK ISSN 1866-3370 ISSN 1866-3389 (electronic) ISBN 978-3-642-28710-7 ISBN 978-3-642-28711-4 (eBook) DOI 10.1007/978-3-642-28711-4 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012938202 Ó Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. -
Temporary Class Drug Order Report: 5-6APB and Nbome Compounds
ACMD Advisory Council on the Misuse of Drugs Chair: Professor Les Iversen Secretary: Rachel Fowler 3rd Floor (SW), Seacole Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 0555 [email protected] Home Secretary Rt Hon. Theresa May MP Home Office 2 Marsham Street London SW1P 4DF 29 May 2013 Dear Home Secretary, I am writing to formally request that you consider laying a temporary class drug order (TCDO) pursuant to section 2A of the Misuse of Drugs Act 1971 on the following two groups of novel psychoactive substances (NPS). We consider the laying of TCDOs is appropriate as a pre-emptive measure in advance of the summer music festival season. Both classes of drugs have been associated with serious harm and drug-related deaths. ‘Benzofury’ compounds 5- and 6-APB and related substances are phenethylamine-type materials, related to ecstasy (MDMA). There have been several deaths and hospitalisations in the UK associated with these NPS, although poly-substance use often complicates the case. Research indicates that there is a potential risk of cardiac toxicity associated with the long-term use of 5- and 6-APB. Anecdotal user reports suggest that the consumption of these substances can cause insomnia, increased heart rate and anxiety, with some users reporting MDMA like symptoms. The related compound 5-IT has been subject to an EMCDDA-Europol joint report and an EMCDDA risk assessment exercise. [www.emcdda.europa.eu/publications/joint-reports/5- IT] 1 The substances recommended for control are: 5- and 6-APB: (1-(benzofuran-5-yl)-propan-2-amine and 1-(benzofuran-6-yl)-propan- 2-amine) and their N-methyl derivatives.