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Ecstasy Or Molly (MDMA) (Canadian Drug Summary)
www.ccsa.ca • www.ccdus.ca November 2017 Canadian Drug Summary Ecstasy or Molly (MDMA) Key Points Ecstasy and molly are street names for pills or tablets that are assumed to contain the active ingredient 3,4-methylenedioxy-N-methamphetamine (MDMA). Although most people consuming ecstasy or molly expect the main psychoactive ingredient to be MDMA, pills, capsules and powder sold as ecstasy or molly frequently contain other ingredients (such as synthetic cathinones or other adulterants) in addition to MDMA and sometimes contain no MDMA at all. The prevalence of Canadians aged 15 and older reporting past-year ecstasy use is less than 1%. 1 in 25 Canadian youth in grades 10–12 have reported using ecstasy in the past 12 months. Introduction Ecstasy and molly are street names for pills, capsules or powder assumed to contain MDMA (3,4- methylenedioxy-N-methamphetamine), a synthetically derived chemical that is used recreationally as a party drug. Pills are typically coloured and stamped with a logo. These drugs are made in illegal laboratories, often with a number of different chemicals, so they might not contain MDMA or contain MDMA in amounts that vary significantly from batch to batch. Other active ingredients found in tablets sold as ecstasy or molly in Canada in 2016–2017 include synthetic cathinones or “bath salts” such as ethylone, methylenedioxyamphetamine (MDA) and its precursor methylenedioxyphenylpropionamide (MMDPPA). Other adulterants reported were caffeine, procaine, methylsulfonylmethane (MSA)and methamphetamine.1 In 2011–2012, paramethoxymethamphetamine (PMMA) was present in pills sold as ecstasy in Canada. This adulteration resulted in the deaths of 27 individuals in Alberta and British Columbia over an 11-month period.2 Effects of Ecstasy Use The effects of ecstasy are directly linked to the active ingredients in the pill. -
Programme & Abstracts
The 57th Annual Meeting of the International Association of Forensic Toxicologists. 2nd - 6th September 2019 BIRMINGHAM, UK The ICC Birmingham Broad Street, Birmingham B1 2EA Programme & Abstracts 1 Thank You to our Sponsors PlatinUm Gold Silver Bronze 2 3 Contents Welcome message 5 Committees 6 General information 7 iCC maps 8 exhibitors list 10 Exhibition Hall 11 Social Programme 14 opening Ceremony 15 Schedule 16 Oral Programme MONDAY 2 September 19 TUESDAY 3 September 21 THURSDAY 5 September 28 FRIDAY 6 September 35 vendor Seminars 42 Posters 46 oral abstracts 82 Poster abstracts 178 4 Welcome Message It is our great pleasure to welcome you to TIAFT Gala Dinner at the ICC on Friday evening. On the accompanying pages you will see a strong the UK for the 57th Annual Meeting of scientific agenda relevant to modern toxicology and we The International Association of Forensic thank all those who submitted an abstract and the Toxicologists Scientific Committees for making the scientific programme (TIAFT) between 2nd and 6th a success. Starting with a large Young Scientists September 2019. Symposium and Dr Yoo Memorial plenary lecture by Prof Tony Moffat on Monday, there are oral session topics in It has been decades since the Annual Meeting has taken Clinical & Post-Mortem Toxicology on Tuesday, place in the country where TIAFT was founded over 50 years Human Behaviour Toxicology & Drug-Facilitated Crime on ago. The meeting is supported by LTG (London Toxicology Thursday and Toxicology in Sport, New Innovations and Group) and the UKIAFT (UK & Ireland Association of Novel Research & Employment/Occupational Toxicology Forensic Toxicologists) and we thank all our exhibitors and on Friday. -
Synergistic Discriminative Effect of LSD and MDMA
European Journal of Pharmacology 341Ž. 1998 131±134 Short Communication `Candyflipping': Synergistic discriminative effect of LSD and MDMA Martin D. Schechter ) Department of Pharmacology, Northeastern Ohio UniÕersities College of Medicine, P.O. Box 95, Rootstown, OH 44272-0095, USA Received 27 October 1997; accepted 28 October 1997 Abstract The co-administration of D-lysergic acid diethylamideŽ. LSD; `Acid' and 3,4-methylenedioxymethamphetamine Ž MDMA; `Ecstasy'; `XTC'. , has reached a prevalence that has allowed for the street terminology `candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mgrkg MDMA and were, subsequently, tested with doses of MDMAŽ.Ž 0.15 mgrkg or LSD 0.04 mgrkg. that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect. q 1998 Elsevier Science B.V. Keywords: Drug discrimination; MDMA; LSD Ž.D-lysergic acid diethylamide ; Candyflipping; Synergism; Ž. Rat 1. Introduction will be citedŽ. http:rrwww sites . This information may be seen to be of suspicious scientific merit yet this source `Candyflipping' is the `street' term for the co-adminis- may allow for extensive subjective and unsolicited infor- tration of D-lysergic acid diethylamideŽ. LSD and 3,4- mation to permit insights into the popular trends in the methylenedioxymethamphetamineŽ. MDMA . The scien- drug culture. Having stated these caveats, the co-adminis- tific literature on the effects of using these two Drug tration of MDMA with LSD has been suggested to ``go Enforcement AgencyŽ. -
Drug Education Student Booklet
WHAT YOU NEED TO KNOW STUDENT VERSION CONTENTS What is a drug? 3 How many young people use drugs and alcohol? 4 Drug and alcohol use and the law 6 Making choices 7 How to help a friend who has taken a drug 10 DRS-ABCD: Basic life support flow chart 13 Putting someone in the recovery position 14 How to help a friend or family member with their drug or alcohol use 15 Drugs A-Z Alcohol 17 Benzodiazepines 18 Cannabis 19 Cocaine 20 GHB 21 Hallucinogens 22 Heroin 23 Inhalants 24 Ketamine 25 MDMA/Ecstasy 26 Methamphetamine 27 New psychoactive substances 28 Synthetic cannabinoids 29 Performance and image-enhancing drugs 30 Tobacco & e-cigarettes 31 Polydrug use 32 Notes 33 Glossary 36 More information and sources of help 37 2 WHAT IS A DRUG? Drugs (including alcohol) are substances that affect the way the body functions when they are used. If a drug is illegal it means that it is forbidden by law. Different drugs have different effects on people, and different factors can impact on the experience of drug use. These include: ● the drug itself (e.g. the pharmacological properties of the substance being taken); ● the individual taking the drug (e.g. age, sex, physical and mental health of a person); ● the environment (the setting where the drug is being used, which can be legal, cultural or situational). Drinking two or three beers might be relatively low risk for a healthy adult but the risk of harm increases if they drink on an empty stomach, try to drive a car after drinking, or have a pre- existing health problem. -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Ecstasy Or Molly, Is a Synthetic Psychoactive Drug
DRUG ENFORCEMENT ADMINISTRATION THE FACTS ABOUT MDMA Ecstasy &Molly DEA PHOTO What is it? MDMA, (3,4-methylenedioxy- methamphetamine), known as Ecstasy or Molly, is a synthetic psychoactive drug. Ecstasy is the pill form of MDMA. Molly is the slang for “molecular” that refers to the powder or crystal form of MDMA. Molly is often mixed with other drugs and substances and is not pure MDMA or safe to use. How is it used? MDMA or Ecstasy is taken orally in pill or tablet form. These pills can be in different colors with images on them. Molly is taken in a gel capsule or snorted. What does MDMA do to the body and mind? • As a stimulant drug, it increases heart rate and blood pressure. Users may experience muscle tension, involuntary teeth clenching, nausea, blurred vision, faintness, chills, or sweating • It produces feelings of increased energy, euphoria, emotional warmth, empathy, and distortions in sensory and time perception. • Feelings of sadness, anxiety, depression and memory difficulties are other effects. • It can seriously deplete serotonin levels in the brain, causing confusion and sleep problems. Did you know? • DEA has labeled MDMA as a Schedule I drug, meaning its abuse potential is high and it has no approved medical use. It is illegal in the U.S. • In high doses, MDMA can affect the body’s ability to regulate temperature, which can lead to serious health complications and possible death. • Teens are using less MDMA. Teens decreased their past year use of MDMA from 1.9% in 2010 to 1.2% of teens using 2012. -
CONTROLLED SUBSTANCE, DRUG, DEVICE and COSMETIC ACT - SCHEDULE I CONTROLLED SUBSTANCES Act of Jun
CONTROLLED SUBSTANCE, DRUG, DEVICE AND COSMETIC ACT - SCHEDULE I CONTROLLED SUBSTANCES Act of Jun. 23, 2011, P.L. 36, No. 7 Cl. 35 Session of 2011 No. 2011-7 SB 1006 AN ACT Amending the act of April 14, 1972 (P.L.233, No.64), entitled "An act relating to the manufacture, sale and possession of controlled substances, other drugs, devices and cosmetics; conferring powers on the courts and the secretary and Department of Health, and a newly created Pennsylvania Drug, Device and Cosmetic Board; establishing schedules of controlled substances; providing penalties; requiring registration of persons engaged in the drug trade and for the revocation or suspension of certain licenses and registrations; and repealing an act," further providing for Schedule I controlled substances. The General Assembly of the Commonwealth of Pennsylvania hereby enacts as follows: Section 1. Section 4(1) of the act of April 14, 1972 (P.L.233, No.64), known as The Controlled Substance, Drug, Device and Cosmetic Act, amended November 24, 1999 (P.L.894, No.55), is amended to read: Section 4. Schedules of Controlled Substances.--The following schedules include the controlled substances listed or to be listed by whatever official name, common or usual name, chemical name, or trade name designated. (1) Schedule I--In determining that a substance comes within this schedule, the secretary shall find: a high potential for abuse, no currently accepted medical use in the United States, and a lack of accepted safety for use under medical supervision. The following controlled substances are included in this schedule: (i) Any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, unless specifically excepted, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation: 1. -
MDMA) Cause Selective Ablation of Serotonergic Axon Terminals in Forebrain: Lmmunocytochemical Evidence for Neurotoxicity
The Journal of Neuroscience, August 1988, 8(8): 2788-2803 Methylenedioxyamphetamine (MDA) and Methylenedioxymetham- phetamine (MDMA) Cause Selective Ablation of Serotonergic Axon Terminals in Forebrain: lmmunocytochemical Evidence for Neurotoxicity E. O’Hearn,” G. Battaglia, lab E. B. De Souza,’ M. J. Kuhar,’ and M. E. Molliver Departments of Neuroscience, and Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and ‘Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224 The psychotropic amphetamine derivatives 3,4-methylene- The synthetic amphetamine derivatives 3,4-methylenedioxy- dioxyamphetamine (MDA) and 3,4-methylenedioxymetham- amphetamine (MDA) and 3,4-methylenedioxymethamphet- phetamine (MDMA) have been used for recreational and amine (MDMA) are potent mood-altering drugs that have at- therapeutic purposes in man. In rats, these drugs cause large tained public interest (Seymour, 1986) due to their widespread, reductions in brain levels of serotonin (5HT). This study self-administration by young adults (e.g., Klein, 1985). These employs immunocytochemistry to characterize the neuro- drugs have also been proposed for medical use in psychotherapy toxic effects of these compounds upon monoaminergic neu- because they produce augmentation of mood and enhanced in- rons in the rat brain. Two weeks after systemic administra- sight (Naranjo et al., 1967; Yensen et al., 1976; Di Leo, 198 1; tion of MDA or MDMA (20 mg/kg, s.c., twice daily for 4 d), Greer and Tolbert, 1986; Grinspoon and Bakalar, 1986). How- there is profound loss of serotonergic (5HT) axons through- ever, concern has been raised about the safety of these com- out the forebrain; catecholamine axons are completely pounds based on evidence that they may be toxic to brain seroto- spared. -
Problematic Use of Nitrous Oxide by Young Moroccan–Dutch Adults
International Journal of Environmental Research and Public Health Article Problematic Use of Nitrous Oxide by Young Moroccan–Dutch Adults Ton Nabben 1, Jelmer Weijs 2 and Jan van Amsterdam 3,* 1 Urban Governance & Social Innovation, Amsterdam University of Applied Sciences, P.O. Box 2171, 1000 CD Amsterdam, The Netherlands; [email protected] 2 Jellinek, Department High Care Detox, Vlaardingenlaan 5, 1059 GL Amsterdam, The Netherlands; [email protected] 3 Amsterdam University Medical Center, Department of Psychiatry, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands * Correspondence: [email protected] Abstract: The recreational use of nitrous oxide (N2O; laughing gas) has largely expanded in recent years. Although incidental use of nitrous oxide hardly causes any health damage, problematic or heavy use of nitrous oxide can lead to serious adverse effects. Amsterdam care centres noticed that Moroccan–Dutch young adults reported neurological symptoms, including severe paralysis, as a result of problematic nitrous oxide use. In this qualitative exploratory study, thirteen young adult Moroccan–Dutch excessive nitrous oxide users were interviewed. The determinants of problematic nitrous oxide use in this ethnic group are discussed, including their low treatment demand with respect to nitrous oxide abuse related medical–psychological problems. Motives for using nitrous oxide are to relieve boredom, to seek out relaxation with friends and to suppress psychosocial stress and negative thoughts. Other motives are depression, discrimination and conflict with friends Citation: Nabben, T.; Weijs, J.; van or parents. The taboo culture surrounding substance use—mistrust, shame and macho culture— Amsterdam, J. Problematic Use of frustrates timely medical/psychological treatment of Moroccan–Dutch problematic nitrous oxide Nitrous Oxide by Young users. -
10 Facts About MDMA
10 Facts About MDMA August 2015 1. What is MDMA? and a desire to intensify these feelings by dancing, talking and touching. MDMA, often referred to as “ecstasy” or “molly”, is short for 3,4 methylenedioxymethamphetamine, a A typical dose of 80 - 125 mg lasts three to six hours. psychoactive drug derived from safrole oil. MDMA Some people experience nausea at the outset, but produces effects that resemble both stimulants and after about 45 minutes, report feelings of relaxation psychedelics, as well as its signature effect: a feeling and clarity. MDMA also causes dilation of the pupils of connectedness. It impacts brain function primarily and, often, sensitivity to light, as well as possible jaw- releasing the neurotransmitter serotonin, and also clenching, tooth-grinding, muscle tension, faintness, temporarily inhibits its reuptake. MDMA is usually and chills or sweating. taken orally, whether in pressed pill form, powder or crystal; or sometimes snorted. After the drug wears off, the theory from preclinical studies is that brain levels of serotonin (a chemical MDMA was originally synthesized in 1912 by the drug responsible for maintaining mood balance) are company Merck.1 However, its psychoactive effects depleted, which can lead in some cases to sadness, weren’t widely discovered until 1976 when Alexander anxiety, depression and sleep problems.4 If they occur, Shulgin developed a new synthesis method, tested the these symptoms arise in the several days that follow. drug on himself, and shared it with a few friendly Generally, they abate within a week, though frequency psychotherapists.2 Because of the drug’s effects of of use and higher doses can slow or stop this increasing empathy and reducing fear, it started to be process.5 used in psychotherapy practices in the 1970s and early 80s, as well as recreationally. -
Expert Peer Review No.2 Agenda Item 4.20: Alpha-Methyltryptamine (AMT)
Expert peer review No.2 Agenda item 4.20: Alpha‐methyltryptamine (AMT) Expert Committee on Drug Dependence Thirty‐sixth Meeting Geneva, 16‐20 June 2014 1. Comments based on the review report a. Evidence on dependence and abuse potential AMT has potential for abuse because it shares many similarities to other hallucinogenic tryptamines and MDMA. It produces amphetamine‐like mood elevating effect and indeed AMT is used as a substitute for MDMA. Human subjects using AMT report euphoria, stimulation, visual effects such as blurry vision, bright colors, after images, primarily hallucinogenic effects. Lower doses of AMT produce stimulant effects and increasing the dose causes more hallucinogenic effects. In animals, AMT produced discriminative stimulus effects similar to DOM and MDMA. As a class, tryptamines are generally not physical or psychological dependence producing. Users report a lack of withdrawal effects following discontinuation of use, even though some cases reported short period of tolerance or feelings of depression following AMT use. Dependence or tolerance potential of AMT is essentially unknown without human pharmacokinetic and controlled pharmacology data. b. Risks to individual and society because of misuse Tryptamines are considered not to produce life‐threatening cardiovascular, renal or hepatic toxicity because of their lack of affinity for the relative targets and receptor, but there have been deaths associated with AMT use especially in combination with other agents such as 3,4‐methylenedioxypyrovalerone, cocaine, amphetamine, cathinones, MDMA, and cannabinoids as investigated by ROAR Forensics laboratory, UK. Other deaths related to AMT have been reported in the US ,Isle of Man, Sweden, Norway, Scotland, UK, and Japan. -
Journal of the House
MAY 5, 2021 1305 Journal of the House SIXTY-SECOND DAY HALL OF THE HOUSE OF REPRESENTATIVES, TOPEKA, KS, Wednesday, May 5, 2021, 10:00 a.m. The House met pursuant to adjournment with Speaker Ryckman in the chair. The roll was called with 122 members present. Reps. Howard and Neighbor were excused on verified illness. Rep. Awerkamp was excused on excused absence by the Speaker. Excused later: Rep. Samsel. Prayer by Chaplain Brubaker: Loving and Merciful God, Thank You for the privilege of another day of life. Today I ask that You show mercy upon our leaders as they continue to face the many challenges. As they continue the pace of their schedules and juggle their obligations, help them to find their strength and encouragement in You. Help them to walk in Your light. May they place their trust in You and allow You to guide their decisions. Keep them in Your care, confident of Your watchfulness. We thank You for the way you are using them in working together on key decisions for our state. Continue to show mercy and grace to them. In Your Name I pray, Amen. The Pledge of Allegiance was led by Rep. Thompson. INTRODUCTION OF BILLS AND CONCURRENT RESOLUTIONS The following bill was introduced and read by title: HB 2454, AN ACT concerning crimes, punishment and criminal procedure; relating to the criminal discharge of a firearm; creating additional violations for discharges near a school and certain projectiles; amending K.S.A. 2020 Supp. 21-6308 and repealing the existing section, by Committee on Federal and State Affairs.