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Home , Hemolysin

AND IMMUNITY

Volume 78 January 2010 No. 1

INSTRUCTIONS TO AUTHORS 2010 Instructions to Authors 1–20

SPOTLIGHT Articles of Significant Interest Selected from This Issue by 21 the Editors

MINIREVIEWS Major Surface Protease of Trypanosomatids: One Size Fits Chaoqun Yao 22–31 All? Precarious Balance: Th17 Cells in Host Defense Ariana Peck and Elizabeth D. 32–38 Mellins

MOLECULAR PATHOGENESIS Functional Characterization of Borrelia spielmanii Outer Annekatrin Seling, Corinna Siegel, 39–48 Surface That Interact with Distinct Members of the Volker Fingerle, Brandon L. Jutras, Human Factor H Family and with Plasminogen Catherine A. Brissette, Christine Skerka, Reinhard Wallich, Peter F. Zipfel, Brian Stevenson, and Peter Kraiczy Systematic Analysis of the SsrAB Virulon of Salmonella Xin Xu and Michael Hensel 49–58 enterica Acid Do Not Contribute to the Pathogenesis Robert Child, Tara D. Wehrly, 59–67 of Type A Dedeke Rockx-Brouwer, David W. Dorward, and Jean Celli The Stability of Cytadherence Proteins in Mycoplasma Sebastian R. Schmidl, Katrin 184–192 pneumoniae Requires Activity of the Protein PrkC Gronau, Claudine Hames, Julia Busse, Do¨rte Becher, Michael Hecker, and Jo¨rg Stu¨lke CcpA and LacD.1 Affect Temporal Regulation of Colin C. Kietzman and Michael G. 241–252 pyogenes Virulence Genes Caparon A Histidine-to-Arginine Substitution in Panton-Valentine Timothe´e Besseyre des Horts, Oana 260–264 Leukocidin from USA300 Community-Acquired Methicillin- Dumitrescu, Ce´dric Badiou, Damien Resistant Does Not Impair Its Thomas, Yvonne Benito, Jerome Leukotoxicity Etienne, Franc¸ois Vandenesch, and Gerard Lina Characterization of a Conditional bosR Mutant in Borrelia Jenny A. Hyde, Dana K. Shaw, 265–274 burgdorferi Roger Smith III, Jerome P. Trzeciakowski, and Jon T. Skare Characterization of Novel ␤-Galactosidase Activity That Vanessa S. Terra, Karen A. Homer, 348–357 Contributes to Glycoprotein Degradation and Virulence in Susmitha G. Rao, Peter W. Andrew, Streptococcus pneumoniae and Hasan Yesilkaya Quorum Sensing Negatively Regulates Hemolysin Amy M. Tsou and Jun Zhu 461–467 Transcriptionally and Posttranslationally in Characterization of Virulence Plasmid Diversity among Sameera Sayeed, Jihong Li, and 495–504 perfringens Type B Isolates Bruce A. McClane

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CELLULAR MICROBIOLOGY: -HOST CELL MOLECULAR INTERACTIONS Division of the Salmonella-Containing Vacuole and Depletion Sandeepa M. Eswarappa, Vidya 68–79 of Acidic Lysosomes in Salmonella-Infected Host Cells Are Devi Negi, Sangeeta Chakraborty, Novel Strategies of Salmonella enterica To Avoid Lysosomes B. K. Chandrasekhar Sagar, and Dipshikha Chakravortty Production of Reactive Oxygen Species Is Turned On and Gae¨lle Boncompain, Benoît 80–87 Rapidly Shut Down in Epithelial Cells Infected with Schneider, Ce´dric Delevoye, Odile Chlamydia trachomatis Kellermann, Alice Dautry-Varsat, and Agathe Subtil Burkholderia mallei Cluster 1 Type VI Secretion Mutants Mary N. Burtnick, David DeShazer, 88–99 Exhibit Growth and Actin Polymerization Defects in RAW Vinod Nair, Frank C. Gherardini, 264.7 Murine and Paul J. Brett Requirement for Formin-Induced Actin Polymerization Jason E. Heindl, Indrani Saran, 193–203 during Spread of Shigella flexneri Chae-ryun Yi, Cammie F. Lesser, and Marcia B. Goldberg CD81 Is Required for monocytogenes To Nam Tham, Edith Gouin, Eric 204–209 Invasion Rubinstein, Claude Boucheix, Pascale Cossart, and Javier Pizarro- Cerda Impairment of Gamma Interferon Signaling in Human Uta Bussmeyer, Arup Sarkar, 358–363 Neutrophils Infected with Anaplasma phagocytophilum Kirsten Broszat, Tanja Lu¨demann, Sonja Mo¨ller, Ger van Zandbergen, Christian Bogdan, Martina Behnen, J. Stephen Dumler, Friederike D. von Loewenich, Werner Solbach, and Tama´s Laskay Human Recognize a Novel Surface Protein, PadA, Helen J. Petersen, Ciara Keane, 413–422 on Streptococcus gordonii through a Unique Interaction Howard F. Jenkinson, M. Margaret Involving Fibrinogen GPIIbIIIa Vickerman, Amy Jesionowski, Janet C. Waterhouse, Dermot Cox, and Steven W. Kerrigan Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Shin-ichi Yokota, Tamaki 468–476 Receptor 4 Expression and Proliferation of Gastric Okabayashi, Michael Rehli, Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Nobuhiro Fujii, and Ken-ichi Protein Kinase Pathway Amano Identification of a Claudin-4 Residue Important for Susan L. Robertson, James G. 505–517 Mediating the Host Cell Binding and Action of Clostridium Smedley III, and Bruce A. McClane perfringens Enterotoxin Mannose Receptor-Dependent Delay in Lindsay Sweet, Prachi P. Singh, 518–526 Maturation by Mycobacterium avium Glycopeptidolipids Abul K. Azad, Murugesan V. S. Rajaram, Larry S. Schlesinger, and Jeffrey S. Schorey

BACTERIAL Characterization of the Highly Regulated Antigen BBA05 in Haijun Xu, Ming He, Xiujuan Pang, 100–107 the Enzootic Cycle of Borrelia burgdorferi Zao C. Xu, Joseph Piesman, and X. Frank Yang Passage through Ixodes scapularis Ticks Enhances the Sarojini Adusumilli, Carmen J. 138–144 Virulence of a Weakly Pathogenic Isolate of Borrelia Booth, Juan Anguita, and Erol burgdorferi Fikrig Absence of Inflammation and during Infection Hanni Lee-Lewis and Deborah M. 220–230 with Nonpigmented Yersinia pestis Reveals a New Role for Anderson the pgm Locus in Pathogenesis

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A Thiolase of Mycobacterium tuberculosis Is Required for Natasha M. Nesbitt, Xinxin Yang, 275–282 Virulence and Production of Androstenedione and Patricia Fonta´n, Irina Kolesnikova, Androstadienedione from Cholesterol Issar Smith, Nicole S. Sampson, and Eugenie Dubnau Effect of MarA-Like Proteins on Antibiotic Resistance and Ida M. Lister, Joan Mecsas, and 364–371 Virulence in Yersinia pestis Stuart B. Levy Norepinephrine Augments Salmonella enterica-Induced Gillian D. Pullinger, Sonya C. 372–380 Enteritis in a Manner Associated with Increased Net Carnell, Fathima F. Sharaff, Pauline Replication but Independent of the Putative Adrenergic M. van Diemen, Francis Dziva, Sensor QseC and QseE Eirwen Morgan, Mark Lyte, Primrose P. E. Freestone, and Mark P. Stevens Mouse Macrophages Are Permissive to Motile Legionella Natalie N. Whitfield, Brenda G. 423–432 Species That Fail To Trigger Byrne, and Michele S. Swanson Mouse Strain-Dependent Differences in Susceptibility to Mathanraj Packiam, Sandra J. Veit, 433–440 Neisseria gonorrhoeae Infection and Induction of Innate Deborah J. Anderson, Robin R. Immune Responses Ingalls, and Ann E. Jerse The Salmonella enterica Serotype Typhi Vi Capsular Antigen Quynh T. Tran, Gabriel Gomez, 527–535 Is Expressed after the Bacterium Enters the Ileal Mucosa Sangeeta Khare, Sara D. Lawhon, Manuela Raffatellu, Andreas J. Ba¨umler, Dharani Ajithdoss, Soma Dhavala, and L. Garry Adams

HOST RESPONSE AND Helicobacter pylori Promotes the Production of Thymic Masahiro Kido, Junya Tanaka, 108–114 Stromal Lymphopoietin by Gastric Epithelial Cells and Nobuhiro Aoki, Satoru Iwamoto, Induces Dendritic Cell-Mediated Inflammatory Th2 Hisayo Nishiura, Tsutomu Chiba, Responses and Norihiko Watanabe CD44 Deficiency Is Associated with Enhanced Escherichia Gerritje J. W. van der Windt, 115–124 coli-Induced Proinflammatory Cytokine and Chemokine Cornelis van Јt Veer, Sandrine Release by Peritoneal Macrophages Florquin, and Tom van der Poll Roles of Capsule and Lipopolysaccharide O Antigen in B. Evrard, D. Balestrino, A. 210–219 Interactions of Human Monocyte-Derived Dendritic Cells Dosgilbert, J.-L. J. Bouya- and Klebsiella pneumoniae Gachancard, N. Charbonnel, C. Forestier, and A. Tridon The Effects of PspC on Complement-Mediated Immunity to Jose Yuste, Suneeta Khandavilli, 283–292 Streptococcus pneumoniae Vary with Strain Background and Naadir Ansari, Kairya Muttardi, Capsular Serotype Laura Ismail, C. Hyams, Jeffrey Weiser, Timothy Mitchell, and Jeremy S. Brown Mycobacterium leprae Actively Modulates the Cytokine Daniel Sinsimer, Dorothy Fallows, 293–300 Response in Naïve Human Monocytes Blas Peixoto, James Krahenbuhl, Gilla Kaplan, and Claudia Manca CXCL10 Production by Human Monocytes in Response to Diego A. Vargas-Inchaustegui, 301–308 Leishmania braziliensis Infection Alison E. Hogg, Gianfranco Tulliano, Alejandro Llanos-Cuentas, Jorge Arevalo, Janice J. Endsley, and Lynn Soong Superantigenic Staphylococcus aureus Stimulates Production Ulrika Islander, Annica Andersson, 381–386 of Interleukin-17 from Memory but Not Naive T Cells Erika Lindberg, Ingegerd Adlerberth, Agnes E. Wold, and Anna Rudin Bacillus anthracis Capsule Activates Caspase-1 and Induces Min-Hee Cho, Hae-Jeong Ahn, 387–392 Interleukin-1␤ Release from Differentiated THP-1 and Hyun-Joon Ha, Jungchan Park, Human Monocyte-Derived Dendritic Cells Jeong-Hoon Chun, Bong-Su Kim, Hee-Bok Oh, and Gi-eun Rhie

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Host Chemokine and Cytokine Response in the Endocervix Roger G. Rank, H. Marie Lacy, 536–544 within the First Developmental Cycle of Chlamydia Anna Goodwin, James Sikes, Judy muridarum Whittimore, Priscilla B. Wyrick, and Uma M. Nagarajan

FUNGAL AND PARASITIC INFECTIONS Localization of Phosphatidylinositol (3,4,5)-Trisphosphate to Yevgeniya A. Byekova, Rhonda R. 125–137 in Entamoeba histolytica Achieved Using Powell, Brenda H. Welter, and Glutathione S-Transferase- and Green Fluorescent Protein- Lesly A. Temesvari Tagged Lipid Biosensors Localization and Developmental Regulation of a Dispersed Noelia Lander, Carolina Bernal, 231–240 Gene Family 1 Protein in Trypanosoma cruzi Nardy Diez, Ne´stor An˜ez, Roberto Docampo, and Jose´ Luis Ramírez Polyfunctional T Lymphocytes Are in the Peripheral Blood Lance Nesbit, Suzanne M. Johnson, 309–315 of Donors Naturally Immune to Coccidioidomycosis and Are Demosthenes Pappagianis, and Neil Not Induced by Dendritic Cells M. Ampel Candida albicans Releases Soluble Factors That Potentiate Shih-Chin Cheng, Louis Y. A. Chai, 393–399 Cytokine Production by Human Cells through a Protease- Leo A. B. Joosten, Anna Activated Receptor 1- and 2-Independent Pathway Vecchiarelli, Bernhard Hube, Jos W. Van Der Meer, Bart Jan Kullberg, and Mihai G. Netea Improved Survival of Mice Deficient in Secretory Krishanthi S. Subramaniam, Kausik 441–452 Immunoglobulin M following Systemic Infection with Datta, Matthew S. Marks, and Liise- Cryptococcus neoformans anne Pirofski A Novel Functional Variant in the Stem Cell Growth Factor Collins Ouma, Christopher C. 453–460 Promoter Protects against Severe Malarial Anemia Keller, Gregory C. Davenport, Tom Were, Stephen Konah, Michael F. Otieno, James B. Hittner, John M. Vulule, Jeremy Martinson, John M. Ong’echa, Robert E. Ferrell, and Douglas J. Perkins Neither Mosquito Saliva nor Immunity to Saliva Has a Chahnaz Kebaier, Tatiana Voza, 545–551 Detectable Effect on the Infectivity of Plasmodium and Jerome Vanderberg Sporozoites Injected into Mice

MICROBIAL IMMUNITY AND VACCINES Prime-Boost Immunization with Adenoviral and Modified Arturo Reyes-Sandoval, Tamara 145–153 Vaccinia Virus Ankara Vectors Enhances the Durability and Berthoud, Nicola Alder, Loredana Polyfunctionality of Protective Malaria CD8؉ T-Cell Siani, Sarah C. Gilbert, Alfredo Responses Nicosia, Stefano Colloca, Riccardo Cortese, and Adrian V. S. Hill The Presence of CD14 Overcomes Evasion of Innate Jennifer C. Chase and Catharine M. 154–167 Immune Responses by Virulent Francisella tularensis in Bosio Human Dendritic Cells In Vitro and Pulmonary Cells In Vivo Discordant Brucella melitensis Antigens Yield Cognate CD8؉ Marina A. Durward, Jerome Harms, 168–176 T Cells In Vivo Diogo M. Magnani, Linda Eskra, and Gary A. Splitter An Orally Applicable Shiga Toxin Neutralizer Functions in Miho Watanabe-Takahashi, Toshio 177–183 the Intestine To Inhibit the Intracellular Transport of the Sato, Taeko Dohi, Noriko Noguchi, Toxin Fumi Kano, Masayuki Murata, Takashi Hamabata, Yasuhiro Natori, and Kiyotaka Nishikawa

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Development of Immunoglobulin M Memory to Both a T- Emily A. Kendall, Abdullah A. 253–259 Cell-Independent and a T-Cell-Dependent Antigen following Tarique, Azim Hossain, Mohammad Infection with Vibrio cholerae O1 in Bangladesh Murshid Alam, Mohammad Arifuzzaman, Nayeema Akhtar, Fahima Chowdhury, Ashraful I. Khan, Regina C. LaRocque, Jason B. Harris, Edward T. Ryan, Firdausi Qadri, and Stephen B. Calderwood Genetic Fusions of Heat-Labile (LT) and Heat-Stable (ST) Weiping Zhang, Chengxian Zhang, 316–325 Toxoids of Porcine Enterotoxigenic Elicit David H. Francis, Ying Fang, David Neutralizing Anti-LT and Anti-STa Knudsen, James P. Nataro, and Donald C. Robertson Salmonella enterica Serovar Typhimurium trxA Mutants Are S. E. Peters, G. K. Paterson, 326–336 Protective against Virulent Challenge and Induce Less E. S. D. Bandularatne, H. C. Inflammation than the Live-Attenuated Vaccine Strain Northen, S. Pleasance, C. Willers, J. SL3261 Wang, A. K. Foote, F. Constantino- Casas, T. J. Scase, B. A. Blacklaws, C. E. Bryant, P. Mastroeni, I. G. Charles, and D. J. Maskell A New Generation of Stable, Nonantibiotic, Low-Copy- James E. Galen, Jin Yuan Wang, 337–347 Number Plasmids Improves Immune Responses to Foreign Magaly Chinchilla, Christopher Antigens in Salmonella enterica Serovar Typhi Live Vectors Vindurampulle, Jeffrey E. Vogel, Haim Levy, William C. Blackwelder, Marcela F. Pasetti, and Myron M. Levine Virulence, Inflammatory Potential, and Adaptive Immunity Ryan T. Ranallo, Robert W. 400–412 Induced by Shigella flexneri msbB Mutants Kaminski, Tonia George, Alexis A. Kordis, Qing Chen, Kathleen Szabo, and Malabi M. Venkatesan Toward the Rational Design of a Malaria Vaccine Construct Lena-Juliette Daher, Corine G. 477–485 Using the MSP3 Family as an Example: Contribution of Demanga, Eric Prieur, Jean-Louis Immunogenicity Studies in Models Pe´rignon, Hasnaa Bouharoun- Tayoun, and Pierre Druilhe Toward the Rational Design of a Malaria Vaccine Construct Corine G. Demanga, Lena-Juliette 486–494 Using the MSP3 Family as an Example: Contribution of Daher, Eric Prieur, Catherine Blanc, Antigenicity Studies in Humans Jean-Louis Pe´rignon, Hasnaa Bouharoun-Tayoun, and Pierre Druilhe A Monoclonal Immunoglobulin G Directed against Lori M. Neal, Joanne O’Hara, 552–561 an Immunodominant Linear Epitope on the Ricin A Chain Robert N. Brey III, and Nicholas J. Confers Systemic and Mucosal Immunity to Ricin Mantis

AUTHOR’S CORRECTION Relative Contributions of OG1RF Kelvin D. Kemp, Kavindra V. Singh, 562 Sortase-Encoding Genes, srtA and bps (srtC), to Biofilm Sreedhar R. Nallapareddy, and Formation and a Murine Model of Barbara E. Murray

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Salmonella-containing vacuoles contain a single bacterium per vacuole. Shown is a confocal laser scanning microscope image of a RAW 264.7 cell infected with green fluorescent protein-expressing Salmonella enterica serovar Typhimurium (green) for 12 h and immunostained for Rab7 (red), a marker for Salmonella-containing vacuoles. The cell shown contains many Salmonella-containing vacuoles that have a single bacterium per vacuole. (See related article on p. 68.)