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Veterinary Orthopedic Society 43Rd Annual Conference Abstracts

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Veterinary Orthopedic Society 43Rd Annual Conference Abstracts A16 2016 VOS Abstracts Veterinary Orthopedic Society purpose of this study was to compare DI measurements with hip arthroscopy findings in dogs undergoing DPO. rd 43 Annual Conference Abstracts Materials and Methods: Medical records, arthroscopic images, and radio- graphs from 14 patients (26 hips) undergoing unilateral or bilateral DPO were reviewed. DI was measured using distraction view radiographs. Arthro- February 27 – March 5, 2016 scopic images were analyzed and findings graded using the Modified Outer- Big Sky, Montana, USA bridge Scale. ANOVA was used to compare DI between grade groups. Results: The highest grades of cartilage wear were noted cranially on the fe- moral head, mid-acetabulum, and caudally on the DAR. No significant dif- Part II ferences in DI were identified between groups of cartilage wear grade on the femoral head, acetabulum, or DAR, nor were any significant differences in DI 2016 VOS Abstracts VOS 2016 PODIUM ABSTRACTS (continued) identified between grade groups for the round ligament, labrum, or degree of synovitis. Discussion/Conclusion: This study found no significant differences in DI 52 COMPARISON OF ULTRASOUND AND MRI TO with different grades of cartilage, DAR, round ligament, or labral wear, or de- ARTHROSCOPY FOR ASSESSMENT OF MEDIAL MENISCAL gree of synovitis. No trend was noted for DI to increase as wear grade in- PATHOLOGY IN DOGS WITH CRANIAL CRUCIATE LIGAMENT creased in any region of the joints evaluated. Arthroscopic evaluation should DISEASE be considered prior to DPO as part of appropriate candidate selection. Acknowledgement: There was no proprietary interest or funding provided Samuel Patrick Franklin1; James L. Cook2; Cristi R. Cook2; Layla Shaikh1; Shannon P Holmes1 for this project 1University of Georgia, Athens, GA, 2University of Missouri, Columbia, MO Introduction: No studies have directly compared the accuracy of ultrasound 54 CORRELATION BETWEEN MRI, MACROSCOPIC AND and MRI for diagnosing medial meniscal pathology in dogs with CCL dis- HISTOLOGIC MEASURES IN A CANINE MODEL OF ease. Further, no assessment of ultrasound has been made when ultrasound is OSTEOARTHRITIS performed by a veterinary surgeon. Frederic H David1; Mark B Hurtig2; Michael G Conzemius3 Materials and Methods: A prospective clinical trial was performed in which 1Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minne- 31 stifles in 26 dogs diagnosed with CCL disease had ultrasound, MRI, and sota, St Paul, MN, 2University of Guelph, Guelph, ON, Canada, 3Veterinary Clinical arthroscopic evaluation of the medial meniscus of the affected stifles. Stifles Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN were evaluated by one surgeon using physical examination, ultrasound, and Introduction: Histology is the gold standard for studies on osteoarthritis arthroscopy for the presence of clinically relevant medial meniscal dam- (OA), but non-invasive T2 mapping MRI, thanks to correlations with bio- age. Video recordings of the arthroscopy were saved and subsequently re- chemical properties of the cartilage, allows longitudinal studies in other viewed by a second arthroscopist that was blinded to all other assessments. A species. The objective of this study was to determine if T2 mapping measures radiologist blinded to all other assessments evaluated MRI images acquired correlated with macroscopic and histological data in a canine model of OA. using a 1.5T scanner. The correct classification rate (CCR), sensitivity, and Materials and Methods: Ten adult male bloodhound dogs underwent right specificity of ultrasound and MRI were calculated twice using each of the two medial meniscal release at the caudal menisco-tibial ligament. Five months arthroscopists’ assessment as the standard. later, MRI was performed, followed by euthanasia and macroscopic and Results: The CCR of ultrasound was 84 and 90%, sensitivity was 86 and 95%, microscopic evaluations. Correlation coefficients were calculated between and specificity was 78 and 82% respectively. These same values for MRI were MRI measures and percentage of abnormal cartilage on India Ink stain, 77 and 84% CCR, 68 and 75% sensitivity, and 100 and 100% specificity. OARSI score and the individual scores pertaining to the cartilage. Discussion/Conclusion: These data are consistent with previous studies per- Results: Correlation coefficients (r2) between MRI, gross pathology, and his- formed independently to assess ultrasound or MRI and suggest imperfect but tologic score were improved when the MFC and MTC were considered to- clinically useful applicability of both ultrasound and MRI. These data also gether. For the medial compartment, MRI to gross pathology had an r2=0.81; provide the first assessment of the accuracy of ultrasound when performed MRI to histologic pathology had an r2=0.17 and gross to histologic pathology by a surgeon with limited ultrasound experience. had an r2=0.28. Acknowledgement: Supported by Hitachi-Aloka and SCiL Animal Care. Discussion/Conclusion: Strong positive correlations between MRI and ab- normal cartilage percentage are explained by higher T2 relaxation time of 53 CORRELATION OF DISTRACTION INDEX WITH ARTHRO- synovial fluid than normal articular cartilage. The limited number of histo- SCOPIC FINDINGS IN JUVENILE DOGS WITH HIP DYSPLASIA logic samples likely explains poor correlations between MRI and gross pa- Emily H. Ulfelder; Caleb C. Hudson; Brian S. Beale thology to histologic correlations. T2 mapping in experimental and clinical Gulf Coast Veterinary Specialists, Houston, TX studies of canine stifle OA could prove to be a valuable method to diagnose cartilage pathology and evaluate response to treatments. Introduction: Hip dysplasia is a common developmental disease of dogs. Acknowledgement: There is no proprietary interest. This project was funded Distraction index (DI) has been recommended as a selection tool in candi- in part by Elanco Animal Health. dates for double pelvic osteotomy (DPO). Arthroscopic evaluation of the hip joint has been reported to be more accurate at identifying pathologic lesions in young dogs with hip dysplasia compared to traditional radiographs. The VOS would like to thank Nexvet Biopharma PLC for their sponsorship support which made publication of these abstracts possible. Vet Comp Orthop Traumatol 3/2016 © Schattauer 2016 Downloaded from www.vcot-online.com on 2016-07-14 | IP: 85.88.216.65 For personal or educational use only. No other uses without permission. All rights reserved. 2016 VOS Abstracts A17 55 SAFETY AND ACCURACY OF MINIMAL INVASIVE LONG Acknowledgement: No proprietary interest or funding was provided for this BONE FRACTURE REPAIR USING A NOVEL INTERLOCKING project. NAIL: A CADAVERIC FELINE STUDY Katrin Nabholz1; Antonio Pozzi2; Philipp A. Schmierer1; Sebastian C. Knell1 57 DISPOSITION AND ULTIMATE FATE OF A PLA-PEG 1Clinic for Small Animal Surgery, Vetsuisse Faculty University of Zurich, Zurich, SUSTAINED RELEASE POLYMER AFTER INTRA-ARTICULAR Switzerland, 2Vetsuisse Faculty University of Zurich, Zurich, Switzerland INJECTION Introduction: The Targon Vet System (TVS) is a novel interlocking nail de- Mark B Hurtig1; Felipe Garcia1; Matthew Shive2; Wayne Marshall2 signed for feline long bone fracture fixation. The purpose of this study was to 1University of Guelph, Guelph, ON, Canada, 2Arthritis Innovation Corporation, compare safety and efficacy of the TVS applied to different long bones per- Toronto, ON, Canada cutaneously with and without the use of fluoroscopy. Introduction: There is an unmet need to manage pain and inflammation as- Materials and Methods: A 10 mm mid-diaphyseal gap was created in 16 hu- sociated with joint disease without the complications associated with oral Abstracts VOS 2016 meri, tibiae and femora from 8 feline cadavers. Paired bones were randomly NSAIDS. The purpose of this work was to study to distribution of a sustained assigned to two treatment groups: 1) TVS inserted percutaneously under flu- release polymer carrier within the synovial space. oroscopy guidance; 2) TVS inserted percutaneously without fluoroscopy. Materials and Methods: Eighteen female adult sheep received an injection of Fracture alignment measured with radiographs, complications and damage 0.6 mL of a biodegradable polylactic acid-polyethylene glycol polymer of neurovascular structures evaluated with dissection were statistically com- (BEPO™, Medincell, Montpellier, France) combined with a generic NSAID pared between treatment groups. into the stifle joint. Plasma and synovial fluid were collected at time 0 to 90 Results: Twelve intraoperative complications occurred in 48 fractures re- days post injection. The sheep were sacrificed and tissues were collected at paired with or without fluoroscopy. These complications were more common time points up to 90 days. in the humerus (44% complications). Neurovascular structures were only Results: Negligible plasma levels of NSAID resulted although synovial fluid damaged repairing humeral fractures (42%). There was no difference in any concentrations were detectable at 28 days. Synovial tissue drug levels re- variable between treatment groups. mained high throughout the study. Polymer was found only within the syn- Discussion/Conclusion: We conclude that the TVS cannot be considered ovial membrane where there was a typical foreign body reaction resulting safe for humeral fractures in cats. In contrast, TVS can be safely applied with degradation to microscopic particles, many of which resided within cells.
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