DOCSLIB.ORG

P.F. DEQUIN Paris, 18 Mars 2014

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
P.F. DEQUIN Paris, 18 Mars 2014 P.F. DEQUIN Paris, 18 mars 2014 Sepsis places a burden on the healthcare system: ◦ 300 per 100,000 in-habitants in North America (Angus NEJM 2013) and in Europe (Annane Lancet 2005) ◦ Increasing incidence (ageing, immunosuppressive therapy) ◦ Kills about 25 to 40% of patients “Lack of well-organized academic networking” identified as one reason for ◦ More than 3 decades of negative trials ◦ Failure to identify any specific treatment for sepsis Clinical research is particular by several aspects: ◦ Population, e.g. syndrome and not disease ◦ Timing issues, e.g. unscheduled 24/7 inclusions ◦ Ethical issues, e.g. waiver for consent CRICS Clinical Research in Intensive Care and Sepsis CICs’ Sepsis Network TRIGGERSEP TRI al Group for Global Evaluation and Research in SEP sis CRICS – from a regional to a national network (12 sites) BRUXELLES ARGENTEUIL STRASBOURG HAUTEPIERRE ORLEANS TOURS DIJON STRASBOURG NHC LA ROCHE / YON POITIERS LIMOGES 2007 : CRICS 1 (6 ICUs) ANGOULEME 2010 : CRICS 2 ( 10 ICUs) MONTAUBAN 2012 : CRICS 3 (12 ICUs) Recruiting capacity: >10,300 admissions per year (60% of ventilated patients) CeNGEPS evaluation (2013): A+ CRICS – Context ”CRICS aims at developing and professionalizing clinical research in patients in critical state especially in the field of Sepsis.” Inclusions 24/7 Short inclusion “windows” Emergency consent Collective participation of all department's physician is needed (continuity of care principle which is specific of this field) Often critical state with major ability to evolve that is hardly compatible with clinical research’s rigor Objectives ◦ Reach a minimum of 10% of research participants among ICU patients ◦ Harmonization across centers ◦ Recognition (worldwide by academia and industry) Coordinating centre ◦ Limoges 2007-2012 (B. François), Tours since 2012 (E. Mercier) Scientific committee (from 2011) Charter for both general functioning and scientific committee Communication & dissemination : ◦ Unique entry door for partners when possible ◦ Annual seminar, quarterly meetings ◦ Biannual newsletter ◦ Network extranet website Standardization ◦ Centralized feasibility as often as possible ◦ Costs and budget ◦ Training (joint staff and investigators) ACCESS – EISAI CRICS 1 : 4 centers Worldwide open centers: 338 / Worldwide inclusions: 1985 CRICS = 10.1% (1.2%) JAMA 2013; 309 (11): 1154-62 IMI 6th call (CAP and AB3SI) ◦ RENARCI + « extended CRICS » IMI 8th call, WP6b ( Staphylococcus VAP) ◦ « extended CRICS » CRICS Clinical Research in Intensive Care and Sepsis CICs’ Sepsis Network TRIGGERSEP TRI al Group for Global Evaluation and Research in SEP sis ARGENTEUIL CIC-BT 1417 BRUXELLES COCHIN PASTEUR CIC-IT 1429 GARCHES CIC-P 1414 RENNES STRASBOURG HAUTEPIERRE ORLEANS TOURS DIJON STRASBOURG NHC LA ROCHE / YON CIC-P 1415 TOURS POITIERS LIMOGES CIC-P 1435 LIMOGES ANGOULEME CRICS CICs’ Sepsis network MONTAUBAN CIC1435 (Limoges) ◦ Linked with ICU ◦ Organization expertise in “Emergency Trials” field ◦ Coordination of CRICS effector network CIC1415 (Tours) ◦ Statistic expertise ◦ Methodological involvement in CRICS academic research ◦ Critical Care Medicine identified as an axis CIC1414 (Rennes) ◦ Data management and biostatistics in Sepsis therapeutic trials ◦ Pharmacology and pharmaco-epidemiology of Sepsis ◦ Specific team “Pharmacology of Sepsis and septic shock” [quadrennial 2012-2015] ◦ CIC1429 (Garches) ◦ Scientific expertise of the coordinating physician in therapeutic trials on Sepsis CIC1417 (Cochin Pasteur) ◦ Scientific expertise in vaccines with possible development ◦ High dynamic of research of the site in Resuscitation and Sepsis field CRICS Clinical Research in Intensive Care and Sepsis CICs’ Sepsis Network TRIGGERSEP TRI al Group for Global Evaluation and Research in SEP sis TRIGGERSEP – Partners PF Laterre (HCL) TRIGGERSEP BRUXELLES CRICS CICs’ Sepsis Network CIC-P 1414 RENNES STRASBOURG HAUTEPIERRE PF Dequin (CRICS) ORLEANS TOURS DIJON STRASBOURG NHC LA ROCHE / YON CIC-P 1415 TOURS POITIERS ARGENTEUIL LIMOGES F Chrétien (Pasteur) CIC-P 1435 LIMOGES S Chevret(APHP) JP Mira (APHP) ANGOULEME CIC-IT 1429 GARCHES B François (LIMOGES) G Monneret (HCL) CIC-BT 1417 COCHIN PASTEUR D Annane (APHP) JD Chiche (APHP) MONTAUBAN Expertise: Clinical Trials Design and Coordination - Sepsis Expertise: Logistical Research Coordination - Sepsis Expertise: Clinical Investigation Coordination Djillali Annane Coordinator Bruno François Pierre-François Co-Coordinator and WP2 Dequin « Investigation Support » WP1 « Clinical Leader Investigation Support » Leader Expertise: Sepsis Trial Expertise: Scientific Coordination – Sepsis Jean-Paul Mira WP3 « Scientific Board » Pierre-François Leader Laterre Europe Interaction WP4 Jean-Daniel Chiche Genomic Research Fabrice Chrétien Neuro-Immunology and Histology Expertise: Human and animal model Histopathology – Experimental pathology - Expertise: Basic Research, Sepsis Sylvie Chevret Neuropathology Guillaume Monneret Responsible for development on new Immunology and Cytometry trial design for Sepsis exploration Expertise: Biostatistics, Clinical Trials, Cohort Studies, Prognosis Expertise: Immunology of Sepsis • Inserm-certified Clinical Investigation Centers CICs’ Sepsis Network (CIC) with their own QMS CRICS Network and • In accordance to local regulations in clinical partners research and abide by policy of their institutions Inserm-certified • Own QMS research units Industrial Partners • Own QMS To realize this global QMS: ◦ Network governance and responsabilities will be made ◦ Quality manager and supervisor will be designated at each structure ◦ Inventory of all existing process and documents will be made ◦ Network process mapping ◦ Network specific documents to be done and applied ◦ Continuous improvement by evaluations, audits and process review Individual vs. population-based approach ◦ Biomarkers ◦ Immuno-Monitoring ◦ Genomic data Innovative tools for sepsis investigations ◦ Databases – datamining / « big » data ◦ Adaptive designs ◦ Research on the influence of qualitative aspects of investigation centres European projects 2014 ◦ TIMES (opTimal Management of the very Elderly with Sepsis) (D. Annane). ◦ Neuro-inflammation and sepsis (F. Chretien) ANR 2014 ◦ OCCSUD (D. Annane) PHRC 2014 ◦ CAP-CODE (Community-Acquired Pneumonia: COrticosteroids Drug Evaluation (PF. Dequin) ◦ CARS (Corticosteroids in ARdS) ◦ RéaNet : Internet information for relatives of septic patients (JP. Mira) ◦ Brain in Sepsis : Brain functionnal imaging and sepsis (T. Sharshar) ANR ◦ Brain functionnal imaging and sepsis (T. Sharshar) ◦ Sepsis-induced immune suppression and secondary infections (F. Pene, G. Monneret, B. François) Cohort (RaDiCo) ◦ Extreme phenotypes of sepsis Investigators ◦ Inter-university Diploma “Investigateur en Recherche Biomédicale” (Universities of Limoges, Poitiers, Rouen & Tours) Clinical Research staff ◦ GCP TRIGGERSEP – SWOT Networking for years Size Recruitment performance Lack of legal organization WEAKNESSES Experience Visibility Synergy Emerging structure Merging CRICS & à la carte networks Particularities of Sepsis Trials Certification process Absence of long term cohort Continuum from basic science to clinical WEAKNESSES research Translational research Difficult global interaction Size Professional platform Financial fragility Industry partnership Ongoing network dynamic Emerging structure Field interface Lack of legal organization Development capacity History of international Ongoing network dynamic leadership Inserm label – University hospitals Unique partner for industry Risk for decrease industry interest in sepsis Tight interaction with European networks Economic crisis THREATS Link with ISARIC and InFact Low awareness of sepsis in lay public and policy makers Difficult global interaction Slowing Translational science Ongoing networkDifficult dynamic global interaction Industry partnership High development capacity Project Manager: to be recruited Until further notice: Isabelle Herafa [email protected].
Load more

Recommended publications
  • Etude Et D’Aménagement Du Bassin D’Influence De La Gare TGV
    -Service Economie, Territoires et Attractivité- Quelle économie autour de la future gare L.G.V ? AVANT-PROPOS L’arrivée de la LGV et de sa nouvelle gare au sein de notre territoire doit servir de véritable levier pour le développement économique. A cet effet, il convient dès à présent de travailler sur un projet à la fois urbain et économique. Nous devons tout faire pour maîtriser et assurer ce développement. La Chambre de Commerce et d’Industrie de Montauban et de Tarn-et-Garonne a donc souhaité prendre les devants et mettre sur la table quelques pistes de réflexion. L’objet de cette étude est donc d’amorcer la réflexion pour un préprogramme. Naturellement, cette étude se veut évolutive en fonction des apports des uns et des autres. N’hésitez donc pas à nous transmettre l’état de vos réflexions à ce sujet. En vous souhaitant une bonne lecture. Jean-Louis MARTY Président SOMMAIRE INTRODUCTION………………………………………………………………Page 1 Diagnostique Economique des territoires concernés par la LGV......................................Page 2 I) Apprendre des autres ……………………………………………….Page 9 II) La question de l’accessibilité et du foncier……………………….Page 26 III) Le Développement Economique dans et autour de la gare………….P 31 a) Dans la gare…………………………………………………………………….Page 31 b) Aux alentours………………………………………………………………...….Page 34 c) Rayonnement départemental et régional…………………………………….Page 39 CONCLUSION……………………………………………………………...…Page 45 Sources…………………………………………………………………………..Page 48 Chambre de Commerce et d’Industrie de Montauban et de Tarn-et-Garonne – Service Economie, Territoires et Attractivité 22, allées de Mortarieu – BP 527– 82065 MONTAUBAN Cedex - INTRODUCTION Dans le cadre du projet de Ligne à Grande Vitesse (LGV) Bordeaux – Toulouse, le département du Tarn-et-Garonne bénéficiera de la construction d’une gare Ligne à Grande Vitesse.
    [Show full text]
  • LES RISQUES MAJEURS DANS LA DROME Dossier Départemental Des Risques Majeurs
    LES RISQUES MAJEURS DANS LA DROME Dossier Départemental des Risques Majeurs PRÉFECTURE DE LA DRÔME DOSSIER DÉPARTEMENTAL DES RISQUES MAJEURS 2004 Éditorial Depuis de nombreuses années, en France, des disposi- Les objectifs de ce document d’information à l’échelle tifs de prévention, d'intervention et de secours ont été départementale sont triples : dresser l’inventaire des mis en place dans les zones à risques par les pouvoirs risques majeurs dans la Drôme, présenter les mesures publics. Pourtant, quelle que soit l'ampleur des efforts mises en œuvre par les pouvoirs publics pour en engagés, l'expérience nous a appris que le risque zéro réduire les effets, et donner des conseils avisés à la n'existe pas. population, en particulier, aux personnes directement Il est indispensable que les dispositifs préparés par les exposées. autorités soient complétés en favorisant le développe- Ce recueil départemental des risques majeurs est le ment d’une « culture du risque » chez les citoyens. document de référence qui sert à réaliser, dans son pro- Cette culture suppose information et connaissance du longement et selon l’urgence fixée, le Dossier risque encouru, qu’il soit technologique ou naturel, et Communal Synthétique (DCS) nécessaire à l’informa- 1 doit permettre de réduire la vulnérabilité collective et tion de la population de chaque commune concernée individuelle. par au moins un risque majeur. Cette information est devenue un droit légitime, défini Sur la base de ces deux dossiers, les maires ont la par l’article 21 de la loi n° 87-565 du 22 juillet 1987 responsabilité d’élaborer des documents d’information relative à l'organisation de la sécurité civile, à la protec- communaux sur les risques majeurs (DICRIM), qui ont tion de la forêt contre l'incendie et à la prévention des pour objet de présenter les mesures communales d’a- lerte et de secours prises en fonction de l’analyse du risques majeurs.
    [Show full text]
  • Horaires Ter
    HORAIRES TER APPLICABLES DU 6 JUILLET TOULOUSE ROUTE DE LAUNAGUETLALANDE EGLISELACOURTENSOURTFENOUILLET ST-ALBANST-JORY CASTELNAU D’ESTRETEFONDSGRISOLLES DIEUPENTALE MONTBARTIER MONTAUBAN AU 14 DÉCEMBRE 2019 TOULOUSE MONTAUBAN Lun Mar Lun Lun Lun Lun Dim Tous Lun Lun Sam Tous à Lun* à à à Sauf Sam Sauf *Ne circule pas les jours fériés Sam à à et les à Dim Sam à Dim les Ven* (sauf exception précisée Ven* Sam* Sam Sam* Sam Ven* Fêtes jours Ven* Ven* Fêtes jours dans le renvoi numéroté) 1 ÉVASIO’FÛTÉ TGV ÉVASIO’FÛTÉ ÉVASIO’FÛTÉ TGV ÉVASIO’FÛTÉ TGV ÉVASIO’FÛTÉ Toulouse-Matabiau 6.02 6.25 6.25 6.46 6.55 7.15 7.39 7.46 7.55 8.47 9.31 10.19 11.48 12.28 12.28 12.55 13.25 Lacourtensourt 7.21 7.52 9.37 12.34 12.34 13.31 Saint-Jory 7.27 7.59 9.44 12.41 12.41 Castelnau-d’Estrétefonds 6.18 6.37 6.37 7.07 7.33 8.04 8.07 9.49 12.46 12.46 13.07 13.41 Grisolles 7.38 8.09 9.54 12.51 12.51 Dieupentale 7.42 8.14 9.59 12.56 12.56 Montbartier 7.48 8.20 10.04 13.01 13.02 Montauban-Ville-Bourbon 6.30 6.51 6.51 7.11 7.21 7.55 8.05 8.28 8.21 9.11 10.12 10.43 12.15 13.09 13.09 13.21 13.59 871802 871604 871604 8500 871810 871608 3644 871820 871810 8504 871824 4754 8508 871616 871616 871816 871644 Sam Tous Sauf Tous Tous Lun Tous Sauf Lun Lun Lun Tous Lun Sam Sauf Lun *Ne circule pas les jours fériés Dim les Ven et Ven* les les à les Sam à à à les à Dim Sam à (sauf exception précisée jours Dim* jours jours Ven* jours Ven* Ven* Ven* jours Ven* Fêtes Ven* dans le renvoi numéroté) 2 1 TGV TGV ÉVASIO’FÛTÉ ÉVASIO’FÛTÉ ÉVASIO’FÛTÉ Toulouse-Matabiau 13.45 14.19 14.28 15.59 16.32 16.45 16.58 17.25 17.28 17.58 18.19 18.28 19.24 19.28 19.30 20.19 20.28 CorrespondanceLacourtensourt TER (car ou train).
    [Show full text]
  • The Development of the Spa in Seventeenth-Century France
    Medical History, Supplement No. 10, 1990, 23-47. THE DEVELOPMENT OF THE SPA IN SEVENTEENTH-CENTURY FRANCE L. W. B. Brockliss THE ESTABLISHMENT OF THE SPA In the Anglo-Saxon world the enthusiasm of the twentieth-century Frenchman for imbibing his country's mineral waters is proverbial. It is surprising, therefore, to discover that the French contribution to the resuscitation of the spa in the era of the Renaissance was minimal. For most ofthe sixteenth century, the nation that has given mankind the waters of Vichy and Evian (to name but two) was largely unmoved by the fad for the hot-spring and the mineral bath that swept the Italian peninsula, crossed the Alps into the territory of the Holy Roman Empire, and penetrated even our own shores. It was not that France's future spas were undiscovered, for many had a Romano-Gallic provenance. It was rather that the therapeutic potential of mineral waters remained unrecognized by the Galenic medical establishment and hence by the large majority of the court, aristocracy, and urban elite who formed their clients. Significantly, when Andreas Baccius published the first general guide to the spas of Europe in 1571 he had little to say about France. Passing reference was made to several Roman foundations but only the virtues of Bourbon-Lancy were described in detail.1 Significantly, too, the only member of the French royal family who definitely did take the waters in the first three-quarters of the sixteenth century was united by marriage to the house of Navarre and patronized, as did her daughter later, the springs of Beam, not those of France.2 The situation first began to change in the 1 580s when a number of local physicians started to promote the waters adjacent to the towns in which they plied their profession.
    [Show full text]
  • Curriculum Vitae
    CURRICULUM VITAE Raymond A. Mentzer Department of Religious Studies 314 Gilmore Hall University of Iowa Iowa City, IA 52242 Phone: 319-335-2161 Fax: 319-335-3716 E-mail: [email protected] EDUCATIONAL AND PROFESSIONAL HISTORY Higher Education University of Wisconsin Ph.D. History 1973 M.A. History 1970 Fordham University A.B. History 1967 Institut d’Études Politiques (Paris) Certificat 1966 Academic Positions Daniel J. Krumm Family Chair in Reformation Studies, Department of Religious Studies, University of Iowa 2001-present Professeur invité, Université de Pau et des Pays de l’Adour, France November 2011 Professeur invité, Université d’Angers, France March 2011 Professeur invité, Université Paul Valéry, Montpellier III, France January-March 2009 Directeur d’études associé, École Pratique des Hautes Études, Section des Sciences Religieuses, Paris March 1997 & January 2003 Professor of History, Montana State University 1973-2001 1 Related Appointments Co-Director, NEH Summer Seminar for College Teachers, “John Calvin and the Transformation of Religious Culture at Geneva, France and Beyond,” Henry H. Meeter Center for Calvin Studies, Grand Rapids, Michigan 28 June-30 July 2004 Associé, Centre d’Histoire moderne et contemporaine de l’Europe méditerranéenne et ses périphéries, Université Paul Valéry, Montpellier III, France 1998-2008 Honors and Awards Lewis Memorial Prize, Huguenot Heritage 2009 Harold J. Grimm Prize, Sixteenth Century Society and Conference 1987 & 2008 Cox Family Award for Creative Research and Teaching, Montana State University 1997 National Huguenot Society Book Prize (for Blood and Belief) 1995 Wiley Research Prize, Montana State University 1985 Phi Kappa Phi 1971 Phi Beta Kappa 1967 Memberships Sixteenth Century Society and Conference Endowment Chair 2010-present Chair, Endowment Campaign 2005-2010 President 1997 Roland Bainton Book Prize Committee 1995 Nancy L.
    [Show full text]
  • Revocation of Edict of Nantes By
    Revocation Of Edict Of Nantes By Which Aleks resits so infinitively that Reginald features her doorways? Germaine formalizing laughably while confiscable Orin clipt fluently or insouls meetly. Unrigged Isa usually osculates some choo-choos or moralising heliacally. Ships same day for your lightboxes will empty your family: and publicly in colonial new settlement of nantes is a visit, which catholic church; those towns are french French academy of revocation of french prison for goading louis xiv, for baptist studies, driven from them indifferently and revocation of nantes by that. Kitts and mail us, apostolic and special places of relapsing into exile of aids, colleges and edict of revocation nantes by a visit, when henry was madame de marly. Earth by clicking i agree, nantes added to any field or black and edict of revocation nantes by henri iv. Revocation of revocation of france not available under cardinal mazarin the edict of revocation nantes by the edict of the middle east. Louis xiv severly weakened his descendants have been a royal notion that this value is in sign language that diversity of revocation of edict of nantes by the edict of aquitaine the. In black and edict will give your intended to be. Huguenots and silk fringe, to neighbouring protestant countries, there is extremely important for this. What was an impressive group came out more necessary cleanliness, to establish them to said religion is fairly democratic is a permanent element in. Please provide all the celebration in the edict separated civil wars with the portal for wanton cruelty. Henry iv in nantes by the edict granted to choose this button id will likewise apply to prove his kingdom.
    [Show full text]
  • Carte Touristique De Lozère
    prête à toutes les explorations. Dans les airs, sur l’eau, sous terre Les Causses et Les Pour des vacances ou à flanc de falaises : des dizaines d’activités de plein air sont Le Parc national des Cévennes proposées, pour tous les goûts et tous les niveaux. Quelle que Découvrez soit l’option choisie, plein d’air pur garanti ! Direction ensuite Cévennes inscrits sur inoubliables, direction les stations thermales, pour voir la vie en rose, ou les parcs animaliers, pour faire de belles rencontres… Et si votre cœur la liste du patrimoine balance plutôt pour les belles pierres, vous n’aurez là-encore que l’embarras du choix, entre villages de caractère et châteaux. mondial de l’UNESCO Alors, que vous soyez seul, en couple, en famille ou entre amis, © E. Henry PER pour vos prochaines vacances, n’hésitez pas une seconde de plus : Les Causses et Cévennes sont inscrits sur la Liste du Patrimoine Rendez-vous mondial de l’Unesco depuis 2011 et couvrent un territoire de plus de Préservée et authentique, la Lozère réserve bien des surprises 3000 km² entre Lozère, Aveyron, Gard et Hérault. Remarquez dans aux voyageurs. Pour vous aider à en percer les mystères et à ce « paysage culturel de l’agropastoralisme méditerranéen » un Lacs, étangs en découvrir les différentes facettes, nous avons conçu la carte patrimoine agricole riche et des panoramas grandioses. que vous tenez entre vos mains, véritable concentré des grands En Cévennes, laissez-vous surprendre par un point de vue sur les et baignades espaces lozériens. Suivez le guide, et vous passerez à coup sûr Découvrez notre magazine RESPIRE, sur simple demande ou terrasses en pierre sèche, ou sur les châtaigneraies qui abritent des vacances mémorables, sous le signe du dépaysement ! sur lozere-tourisme.com des ruches troncs.
    [Show full text]
  • Dossier De Candidature Fevrier 2019
    4 1 DOSSIER DE CANDIDATURE FEVRIER 2019 :: MODALITÉS D’ENTRÉE EN FORMATION Votre inscription sera considérée comme définitive après : Date de réception : _______________________________________________ Date de validation : _______________________________________________ - votre participation à une réunion d’information Cadre réservé à l’établissement Toutes les rubriques - réception du dossier complet (fiche complétée et signée + pièces listées ci-dessous) :: ÉTABLISSEMENT ENVISAGÉ doivent être - test(s) de positionnement ou entretien complétées avec Alès Ariège Aveyron Béziers Carcassonne Lot Lozère Montauban précision et en - signature d’un contrat d’apprentissage ou de professionnalisation (sauf pour l’École de l’Apprentissage) lettres capitales. Montpellier Narbonne Nîmes Perpignan Sète Tarn :: FORMATION CHOISIE :: PIÈCES À JOINDRE AU PRÉSENT FORMULAIRE CAP Mention Complémentaire CQP Bac pro BP BTS Bac+2 Bac+3 Objectif apprentissage Curriculum Vitæ Intitulé du diplôme : _____________________________________ ___________________________________________________________________________________ VOTRE Lettre de motivation pour l’entreprise PHOTO Photocopie du dernier diplôme OU relevé de notes et attestation de réussite Nom : _________________________________________________________ Prénom : ______________________________________________ :: ÉTAT CIVIL À COLLER ICI Photocopie des 3 derniers bulletins scolaires Sexe (H/F) : _______ Nationalité : __________________________________________________ Date de naissance : ________________________________
    [Show full text]
  • HORAIRES Lio TER
    HORAIRES liO TER APPLICABLES DU 13 DÉCEMBRE 2020 TOULOUSE MONTAUBAN ALBIAS REALVILLE CAUSSADE LALBENQUE FONTANESCAHORS DEGAGNAC GOURDON SOUILLAC GIGNAC - CRESSENSACBRIVE LA GAILLARDE AU 02 JUILLET 2021 AGEN BORDEAUX BRIVE MONTAUBAN TOULOUSE Lun Lu Lun Tous Dim Lun Tous Lun Sam Lun Tous Lun Dim Tous Tous Tous * Ne circule pas les jours fériés Lun à à à les et Sam à les à Dim à les à et à Sam les les les (sauf exception précisée Ven* Jeu Ven* jours Fêtes Ven* jours Ven* Fêtes Ven* jours Sam* Fêtes jours jours jours dans le renvoi numéroté) 1 2 3 4 liO train liO train liO train liO train liO train liO train liO train liO train liO train liO train liO train TGV liO train TGV Brive-la-Gaillarde 6.01 6.15 6.28 7.17 8.28 9.17 10.28 11.03 Gignac-Cressensac 6.15 6.29 Souillac 6.27 6.41 6.53 7.41 8.53 9.42 10.53 11.29 Gourdon 6.42 6.56 7.08 7.56 9.08 9.57 11.08 11.45 Dégagnac 6.51 7.05 Cahors 6.23 7.09 7.23 7.34 7.34 8.22 9.34 9.34 10.22 11.34 11.34 12.13 13.34 Lalbenque-Fontanes 6.35 7.22 7.35 7.47 7.47 8.34 9.47 9.47 11.47 11.47 13.47 Caussade-Tarn-et-Garonne 6.51 7.36 7.50 8.03 8.02 8.49 10.03 10.02 12.03 12.02 12.39 14.03 Albias 6.58 7.44 7.58 8.10 8.10 8.57 10.10 10.10 12.10 12.10 14.10 Montauban-Ville-Bourbon 7.08 7.54 8.08 08.15 8.20 8.20 9.07 10.15 10.20 10.20 12.15 12.20 12.20 12.53 14.15 14.20 14.46 Montbartier 8.02 8.29 8.28 10.29 10.29 12.28 12.29 14.29 Dieupentale 8.07 8.34 8.34 10.34 10.34 12.34 12.34 14.34 Grisolles 8.12 8.39 8.39 10.39 10.39 12.38 12.39 14.39 Castelnau-d’Estrétefond 7.25 8.17 8.25 8.44 8.44 9.24 10.44 10.44 12.43
    [Show full text]
  • Box 17:19:44 Strasbourg, France (H00514691Q)
    New York Academy of Medicine Collection of International Medical Theses Box 17:19:44 Strasbourg, France (H00514691Q) The following titles are part of the New York Academy of Medicine Collection of International Medical Theses, housed at the University of North Carolina at Chapel Hill’s Health Sciences Library. The collection consists of tens of thousands of post-1801 theses in multiple languages from leading medical schools throughout the world. Europe is well represented, with many theses originating from universities in Germany, France, the Netherlands, Spain, Sweden, and Switzerland. Countries with lesser quantities in the collection include Argentina, Brazil, Chile, Algeria, Indonesia, and others. For a complete listing of titles or to request items, please refer to the finding aid: http://finding-aids.lib.unc.edu/HC0011/ FACULTE DE MEDECINE DE STRASBOURG Annee 1967 t;Jo 29 THESE PRESENTEE POUR LE DOCTORAT EN MEDECINE PAR ·. BAER Roger .. Ne a Strasbourg (Bas-Rhin) le 4 mars 1937 lnterne des Hopitaux de Strasbourg Le reve dans les etats depressifs. Etude de 29 cas. President: Mr Th. KAMMERER, Professeur ANNEE 1967 FACULTE DE MEDECINE DE STRASBOURG THESE presentee pour le DOCTORAT EN MEDECINE par Djemel-Eddine BARBARA ne le 9 janvier I 938 a Constantine Les pseudo-tumeurs post-traumatiques du colon ; A propos d'un cas President : Paul BUCK, Profewmr Le 22 Juin 1967 FACULTE DE MEDECINE DE STRASBOURG Annee 1967 No 70 THESE PRESENTEE POUR LE DOCTORAT EN MEDECINE PAR ) BARBIER Marcel I I ne le 26 avril 1937 a BLIES-SCHWEYEN (Moselle), A propos d'un cas de Mucinose folliculaire de l'adulte symptomatique d'une reticulose.
    [Show full text]
  • Cruising Bordeaux Waterways
    V O L 4 . 1 F R E E D O W N L O A D discover Sharing our love for France's spectacular waterways Bordeaux Fruitful orchards, picturesque villages, buzzing cities, designer shopping and world renowned wines P A G E 2 Barging in Bordeaux YOUR COMPLETE GUIDE TO THE PERFECT CANAL CRUISE Why choose Bordeaux Would it be the wine, or the climate, or the fruitful orchards, or Canal de Garonne the picturesque villages? Aquitaine, bordered by the Pyrenees Produce, cuisine & wine and the Atlantic in the southwest of France, has it all. Top spots When to go The stunning city of Bordeaux, the regional capital and second How to cruise only to Paris, lies on the crescent-shaped banks of the river Contact us Garonne, forever associated with some of the best wines in the world. Just to whet your appetite, it has the biggest shopping area in Europe, around the Rue St Catherine, and the stunning old quarter has UNESCO World Heritage status. Ruth & the team P A G E 3 THE CANAL DE GARONNE The Canal de Garonne could be described as the little sister of the Canal du Midi and together they have recently been re-classified as the Canal des Deux Mers. It is possible to start at Sète on the Mediterranean coast and navigate all the way to Bordeaux on the Atlantic Coast. The Canal de Garonne picks up where the Midi finishes, in the ‘Rose City’ of Toulouse, and was completed in 1856. There are 193 kilometres, 53 locks and 83 bridges along its length (and that doesn’t include the Canal du Montech, a small spur which branches down to Montauban, birthplace of the painter Georges Ingres).
    [Show full text]
  • English-Speaking Attorneys in France
    ACS List of Attorneys – February 2020 Suf English-Speaking Attorneys in France Disclaimer: The U.S. Embassy Paris, France assumes no responsibility or liability for the professional ability or reputation of, or the quality of services provided by the following persons or firms. Inclusion on this list is in no way an endorsement by the Department of State or the U.S. Embassy/Consulate. Names are listed alphabetically, and the order in which they appear has no other significance. The information in the list on professional credentials, areas of expertise and language ability are provided directly by the lawyers. You may receive additional information about the individuals by contacting the local bar association (or its equivalent) or the local licensing authorities. Important Note: Officers of the Department of State and U.S. Embassies and Consulates abroad are prohibited by federal regulation from acting as agents, attorneys or in a fiduciary capacity on behalf of U.S. citizens in private legal disputes abroad. (22 CFR 92.81, 10.735-206(a)(7), 72.41, 71.5.) Generally, this list is revised triennially with interim addendum as needed. U.S. Department of State's Role Officers of the Department of State and U.S. embassies and consulates overseas are prohibited by federal regulation from acting as agents, attorneys or in a fiduciary capacity on behalf of U.S. citizens involved in legal disputes overseas. Department of State personnel, including its attorneys, do not provide legal advice to the public. The List of Attorneys: The following individuals and firms have informed the Embassy that they are qualified to adjudicate law in the categories specified and that they are sufficiently competent in the English language to provide services to English-speaking clients.
    [Show full text]