bioRxiv preprint doi: https://doi.org/10.1101/2020.09.02.279133; this version posted September 3, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 ETV7 regulates breast cancer stem-like cell plasticity by repressing IFN- 2 response genes 3 4 5 6 7 Laura Pezzè1,#, Mattia Forcato2, Stefano Pontalti1,^, Kalina Aleksandra Badowska1,#, Dario 8 Rizzotto3,°, Ira-Ida Skvortsova4,5, Silvio Bicciato2, Yari Ciribilli1,§ 9 10 11 12 1 Laboratory of Molecular Cancer Research, Department of Cellular, Computational and Integrative 13 Biology (CIBIO), University of Trento, Italy; 2 Department of Life Sciences, University of Modena 14 and Reggio Emilia, Italy; 3 Laboratory of Transcriptional Networks, Department CIBIO, University 15 of Trento, Italy; 4 EXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical 16 University of Innsbruck, Austria; 5 Tyrolean Cancer Research Institute, Innsbruck, Austria 17 # present address: Alia Therapeutics s.r.l., Trento, Italy 18 ^ present address: Azienda Provinciale per i Servizi Sanitari, APSS, Trento, Italy 19 °present address: CeMM Research Center for Molecular Medicine of the Austrian Academy of 20 Sciences, Vienna, Austria 21 § correspondence:
[email protected] (YC) 22 23 24 25 Running Title: ETV7 regulates BCSCs plasticity 26 27 28 Keywords: ETV7 – Cancer stem cells – Breast cancer – Interferon – Chemoresistance 29 30 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.02.279133; this version posted September 3, 2020.