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Rare Presentation of Metastatic Lobular Breast Carcinoma Involving Clear Cell Renal Cell Carcinoma
Hindawi Case Reports in Oncological Medicine Volume 2020, Article ID 5315178, 5 pages https://doi.org/10.1155/2020/5315178 Case Report Rare Presentation of Metastatic Lobular Breast Carcinoma Involving Clear Cell Renal Cell Carcinoma Dayne Ashman,1 Gabriela Quiroga-Garza,1 and Daniel Lee 2 1Department of Pathology, University of Pittsburgh, 5230 Centre Avenue, Pittsburgh, PA 15232, USA 2Department of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA 15232, USA Correspondence should be addressed to Daniel Lee; [email protected] Received 23 March 2020; Accepted 3 September 2020; Published 15 September 2020 Academic Editor: Raffaele Palmirotta Copyright © 2020 Dayne Ashman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Although the first case of tumor-to-tumor metastasis was reported over a century ago, it remains a rare occurrence. We report a rare case of metastatic infiltrating lobular carcinoma involving clear cell renal cell carcinoma, as well as offer a brief literature review. 1. Introduction Microscopic examination of the biopsy specimen revealed two distinct neoplasms (Figure 3). The first neo- The phenomenon of one malignant tumor metastasizing to plasm identified demonstrated cells arranged in nests and another, unrelated, primary tumor, has been termed solid sheets with delicate vasculature. Cytologically, these “tumor-to-tumor” metastasis (TTM); it is a rare occurrence. neoplastic cells demonstrated clear cytoplasm with round To date, there have been fewer than 200 cases reported in nuclei and inconspicuous nucleoli, morphologically consis- the English literature. -
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University Journal of Pre and Para Clinical Sciences ISSN 2455–2879 2017, Vol.3(4) SOLITARY FIBROUS TUMOR OF LUNG MIMICKING AS LUNG METASTASIS IN A KNOWN CASE OF WILMS TUMOR. SELVI Department of Pathology, MADRAS MEDICAL COLLEGE AND GOVERNMENT GENERAL HOSPITAL Abstract : Solitary fibrous tumor is the most common benign mesenchymal pleural neoplasm. It also affects mediastinum, lungs and other organs of any individual from young children to adults without sex predilection. Here we report a case of 4 years old child, a known case of treated Wilms tumor, presenting with a Solitary fibrous tumor of lung that was clinically mistaken for a lung metastasis. Ametachronous benign tumor occurring after a malignant tumor is a rare entity and whether it could bea part of any syndrome could not be established due to lack of molecular diagnostic studies. Keyword :Metachronous tumor Wilms tumor - Solitary fibrous tumor Lung. FIG 2 CT Image Axial View Mass Lesion R Lung INTRODUCTION: As the patient is a known case of Wilms tumor operated one year back, a clinical diagnosis ofmetastatic Solitary Fibrous Tumor (SFT) is a rare benign neoplasm Wilms tumor was considered. Right thoracotomy was done and arising from pleura, mediastinum and the tumor was seen as a huge pleuro pulmonary mass and the lungs and virtually at any anatomic location. The tumor is most tumor was excised. The child gave a past history of being common in patients between 20 and 70years old. Hence we operated for Wilm’s tumor – Triphasic type, one year back, report a rare case of pulmonary SFT in 4year old child, who was followed by chemo and radiotherapy for the same ailment. -
Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD
4/1/2020 Soft Tissue Cytopathology: A Practical Approach Liron Pantanowitz, MD Department of Pathology University of Pittsburgh Medical Center [email protected] What does the clinician want to know? • Is the lesion of mesenchymal origin or not? • Is it begin or malignant? • If it is malignant: – Is it a small round cell tumor & if so what type? – Is this soft tissue neoplasm of low or high‐grade? Practical diagnostic categories used in soft tissue cytopathology 1 4/1/2020 Practical approach to interpret FNA of soft tissue lesions involves: 1. Predominant cell type present 2. Background pattern recognition Cell Type Stroma • Lipomatous • Myxoid • Spindle cells • Other • Giant cells • Round cells • Epithelioid • Pleomorphic Lipomatous Spindle cell Small round cell Fibrolipoma Leiomyosarcoma Ewing sarcoma Myxoid Epithelioid Pleomorphic Myxoid sarcoma Clear cell sarcoma Pleomorphic sarcoma 2 4/1/2020 CASE #1 • 45yr Man • Thigh mass (fatty) • CNB with TP (DQ stain) DQ Mag 20x ALT –Floret cells 3 4/1/2020 Adipocytic Lesions • Lipoma ‐ most common soft tissue neoplasm • Liposarcoma ‐ most common adult soft tissue sarcoma • Benign features: – Large, univacuolated adipocytes of uniform size – Small, bland nuclei without atypia • Malignant features: – Lipoblasts, pleomorphic giant cells or round cells – Vascular myxoid stroma • Pitfalls: Lipophages & pseudo‐lipoblasts • Fat easily destroyed (oil globules) & lost with preparation Lipoma & Variants . Angiolipoma (prominent vessels) . Myolipoma (smooth muscle) . Angiomyolipoma (vessels + smooth muscle) . Myelolipoma (hematopoietic elements) . Chondroid lipoma (chondromyxoid matrix) . Spindle cell lipoma (CD34+ spindle cells) . Pleomorphic lipoma . Intramuscular lipoma Lipoma 4 4/1/2020 Angiolipoma Myelolipoma Lipoblasts • Typically multivacuolated • Can be monovacuolated • Hyperchromatic nuclei • Irregular (scalloped) nuclei • Nucleoli not typically seen 5 4/1/2020 WD liposarcoma Layfield et al. -
PROPOSED REGULATION of the STATE BOARD of HEALTH LCB File No. R057-16
PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 Section 1. Chapter 457 of NAC is hereby amended by adding thereto the following provision: 1. The Division may impose an administrative penalty of $5,000 against any person or organization who is responsible for reporting information on cancer who violates the provisions of NRS 457. 230 and 457.250. 2. The Division shall give notice in the manner set forth in NAC 439.345 before imposing any administrative penalty 3. Any person or organization upon whom the Division imposes an administrative penalty pursuant to this section may appeal the action pursuant to the procedures set forth in NAC 439.300 to 439. 395, inclusive. Section 2. NAC 457.010 is here by amended to read as follows: As used in NAC 457.010 to 457.150, inclusive, unless the context otherwise requires: 1. “Cancer” has the meaning ascribed to it in NRS 457.020. 2. “Division” means the Division of Public and Behavioral Health of the Department of Health and Human Services. 3. “Health care facility” has the meaning ascribed to it in NRS 457.020. 4. “[Malignant neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. [4] “Medical laboratory” has the meaning ascribed to it in NRS 652.060. 5. “Neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. 6. “[Physician] Provider of health care” means a [physician] provider of health care licensed pursuant to chapter [630 or 633] 629.031 of NRS. 7. “Registry” means the office in which the Chief Medical Officer conducts the program for reporting information on cancer and maintains records containing that information. -
Fascin‑1 Is Associated with Recurrence in Solitary Fibrous Tumor/Hemangiopericytoma
MOLECULAR AND CLINICAL ONCOLOGY 15: 199, 2021 Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma YUMIKO YAMAMOTO1, YOSHIHIRO HAYASHI2, HIDEYUKI SAKAKI3 and ICHIRO MURAKAMI1,4 1Department of Diagnostic Pathology, Kochi University Hospital, Kochi University; 2Equipment of Support Planning Office, Kochi University, Nankoku, Kochi 783‑8505; 3Department of Nutritional Sciences for Well‑being Health, Kansai University of Welfare Sciences, Kashiwa, Osaka 582‑0026; 4Department of Pathology, School of Medicine, Kochi University, Nankoku, Kochi 783‑8505, Japan Received March 31, 2021; Accepted July 15, 2021 DOI: 10.3892/mco.2021.2361 Abstract. Fascin‑1, an actin‑bundling protein, is associated epithelial membrane antigen (1‑5). This lack of specificity in with poor prognosis in patients with various types of SFT/HPC occasionally caused problems in differentiating human carcinoma. However, research is limited on the role them from other tumors that are immunohistologically alike of fascin‑1 in sarcoma. Solitary fibrous tumor (SFT) and them. In 2013, three groups reported that SFT and HPC have hemangiopericytoma (HPC) are rare sarcomas derived from the a common gene fusion between NGFI‑A‑binding protein 2 mesenchyme. Although the prognosis of SFT/HPC is generally (NAB2) and signal transducer and activator of transcription 6 favorable, fatalities are possible with repeated recurrence (STAT6) (1,6,7). Thereafter, STAT6, which has dual functions and distant metastasis. The current study included a total of as a signal transducer and as transcription activator in SFT 20 Japanese patients, who were diagnosed with SFT/HPC and and HPC, was recognized as the highly sensitive and specific underwent surgery at Kochi University Hospital from January immunohistochemical marker for SFT/HPC (2‑5,8‑11). -
Rare Pancreatic Tumors
Published online: 2020-04-29 THIEME 64 ReviewRare Pancreatic Article Tumors Choudhari et al. Rare Pancreatic Tumors Amitkumar Choudhari1,2 Pooja Kembhavi1,2 Mukta Ramadwar3,4 Aparna Katdare1,2 Vasundhara Smriti1,2 Akshay D. Baheti1,2 1Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, Address for correspondence Akshay D. Baheti, MD, Department of Maharashtra, India Radiodiagnosis, Tata Memorial Hospital, Ernest , Borges Marg Parel 2Department of Radiodiagnosis, Homi Bhabha National University, Mumbai 400012, India (e-mail: [email protected]). Mumbai, Maharashtra, India 3Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India 4Department of Pathology, Homi Bhabha National University, Mumbai, Maharashtra, India J Gastrointestinal Abdominal Radiol ISGAR 2020;3:64–74 Abstract Pancreatic ductal adenocarcinoma, neuroendocrine tumor, and cystic pancreatic neo- plasms are the common pancreatic tumors most radiologists are familiar with. In this Keywords article we review the clinical presentation, pathophysiology, and radiology of rare pan- ► pancreatic cancer creatic neoplasms. While the imaging features are usually nonspecific and diagnosis is ► uncommon based on pathology, the radiology along with patient demographics, history, and lab- ► pancreatoblastoma oratory parameters can often help indicate the diagnosis of an uncommon pancreatic ► acinar cell neoplasm and guide appropriate management in these cases. ► lymphoma Introduction hyperlipasemia may rarely lead to extraabdominal manifes- tations like ectopic subcutaneous fat necrosis and polyarthri- Pancreatic tumors of various histological subtypes can be tis (lipase hypersecretion syndrome).4 encountered in clinical practice, most common being pan- These tumors are hypoenhancing compared with the pan- creatic ductal adenocarcinoma (PDAC), which constitutes creas and are frequently associated with cystic or necrotic 85% of all pancreatic neoplasms.1 Histologically pancreat- areas as well as calcifications5,6 (►Fig. -
Solitary Fibrous Tumor of the Pleura: Histology, CT Scan Images and Review of Literature Over the Last Twenty Years
DOI: 10.26717/BJSTR.2017.01.000150 Flavio Colaut. ISSN: 2574-1241 Biomed J Sci & Tech Res Case Report Open Access Solitary Fibrous Tumor of the Pleura: Histology, CT Scan Images and Review of Literature over the Last Twenty Years Giulia Bora1, Flavio Colaut2*, Gianni Segato3, Luisa Delsedime4 and Alberto Oliaro1 1Department of Thoracic Surgery, University of Turin, Italy 2Department of General Surgery and Thoracic, City Hospital , Montebelluna, (Treviso), Italy 3Department of General Surgery, S. Bortolo City Hospital, Vicenza, Italy 4Department of Pathology, University of Turin, Italy Received: June 14, 2017; Published: June 26, 2017 *Corresponding author: Flavio Colaut, Department of General Surgery, City Hospital Montebelluna, Thoracic City Hospital, via Montegrappa 1, 31044 Montebelluna (Treviso), Italy, Tel: ; Fax: 0499367643; Email: Introduction Literature up to 800 cases [1-3] have been reported, and these in case of recurrence [10,16,17]. In less than 5% of patients with Solitary fibrous tumor of the pleura is a rare neoplasm. In numbers show its rarity, despite of mesotheliomas, the most pleural SFPTs an increase of insulin-like factor II type occur and this causes refractory to therapy hypoglycaemia (Doege-Potter syndrome) similar in both sexes and there no differences in both benign and [10,18,19]. The incidence of Doege-Potter syndrome in SFPT is tumors represented. Males and females are equal distributed asbestos, tobacco or others environmental agents, were found for and the same is true for age. No correlation with exposure to malignantSome patients forms. may also present gynecomastia or galactorrhoea its development. Solitary fibrous tumor of the pleura occurs as localized neoplasms of the pleura and was initially classified as microscope and immunohistochemistry, has been possible [1]. -
Activity of Larotrectinib, a Highly Selective Inhibitor of Tropomyosin
Activity of larotrectinib, a highly selective inhibitor of tropomyosin receptor kinase, in TRK fusion breast cancers Funda Meric-Bernstam,1 Neerav Shukla,2 Nir Peled,3,4 Yosef Landman,3 Adedayo A. Onitilo,5 Sandra Montez,1 Nora C Ku,6 David M. Hyman,2 Alexander Drilon,2 David S. Hong1 1The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; 2Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York, USA; 3Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel; 4Soroka Cancer Institute, Ben Gurion University, Beer Sheva, Israel; 5Marshfield Clinic Weston Center, Weston, Wisconsin, USA;6 Loxo Oncology, Inc., South San Francisco, California, USA San Antonio Breast Cancer Symposium® - December 4-8, 2018 Introduction Table 1: Adverse events with larotrectinib seen in ≥15% of patients Patient case studies Patient 3: ETV6-NTRK3 secretory breast cancer Patient 5: ETV6-NTRK3 secretory breast cancer (n=207)4 ■■ The family of tropomyosin receptor kinases (TRK), TRKA, B, and C are encoded by three distinct genes, NTRK1, 2, and 31 Treatment-emergent AEs (%) Treatment-related AEs (%) Patient 1: TPM3-NTRK1 invasive ductal carcinoma of the breast Baseline Day 54 Baseline Cycle 17, day 27 ■■ After embryogenesis, TRK proteins are primarily restricted to the nervous system and function during Grade 1 Grade 2 Grade 3 Grade 4 Total Grade 3 Grade 4 Total normal neuronal development and maintenance2–5 ■■ 34-year-old female diagnosed with invasive ductal carcinoma with metastasis -
Variants of Acinar Adenocarcinoma of the Prostate Mimicking Benign Conditions Peter a Humphrey
Modern Pathology (2018) 31, S64–S70 S64 © 2018 USCAP, Inc All rights reserved 0893-3952/18 $32.00 Variants of acinar adenocarcinoma of the prostate mimicking benign conditions Peter A Humphrey Department of Pathology, Yale School of Medicine, New Haven, CT, USA Histological variants of acinar adenocarcinoma of the prostate may be of significance due to difficulty in diagnosis or due to differences in prognosis compared to usual acinar adenocarcinoma. The 2016 World Health Organization classification of acinar adenocarcinoma includes four variants that are deceptively benign in histological appearance, such that a misdiagnosis of a benign condition may be made. These four variants are atrophic pattern adenocarcinoma, pseudohyperplastic adenocarcinoma, microcystic adenocarcinoma, and foamy gland adenocarcinoma. They differ from usual small acinar adenocarcinoma in architectural glandular structure and/or cytoplasmic and nuclear alterations. The variants are often admixed, in variable proportions, with usual small acinar adenocarcinoma that is often Gleason pattern 3 but may be high-grade pattern 4 in a minority of cases. Atrophic pattern adenocarcinoma can be identified in a sporadic setting or after radiation or hormonal therapy. This variant is characterized by cytoplasmic volume loss and can resemble benign glandular atrophy, an extremely common benign process in the prostate. The glands of pseudohyperplastic adenocarcinoma simulate usual epithelial hyperplasia, with gland complexity that is not typical of small acinar adenocarcinoma. These complex growth configurations include papillary infoldings, luminal undulations, and branching. Microcystic adenocarcinoma is characterized by cystic dilation of prostatic glands to a size that is much more commonly observed in cystic change in benign prostatic glands. Finally, the cells in foamy gland adenocarcinoma display cytoplasmic vacuolization and nuclear pyknosis, features that can found in benign glands and macrophages. -
Supplementary Table 1) Immunohistochemical Protocol and Antibody Information Antibody Company Clone/# Clonality Dilution Incubat
H. Reis et al: Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas Suppl ementary Table 1) Immunohistochemical protocol and antibody information Antibody Company Clone/# Clonality Dilution Incubation Antigen retrieval Detection ABAT Abcam EPR4433 mono 1/3000 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP ACAA2 Abcam EPR6733 mono 1/100 30 min, RT pH 9.0, WB, 95°C, 20 min Zytomed Polymer HRP ACADM Abcam EPR3708 mono 1/3000 30 min, RT pH 9.0, WB, 95°C, 20 min Zytomed Polymer HRP ADH1B Abcam 4F12 mono 1/12.000 30 min, RT pH 9.0, WB, 95°C, 20 min Zytomed Polymer HRP Arginase1 Abcam EPR6672(B) mono 1/1000 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP BHMT Abcam EPR6782 mono 1/100 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP FABP1 Acris AIV\09011PU-S mono 1/15.000 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP HAOX1 Acris AP18044PU-N poly 1/100 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP HepPar1 Dako OCH1E5 mono 1/800 30 min, RT pH 9.0, WB, 95°C, 20 min. Zytomed Polymer HRP HMGCS2 Abcam Ab104807 poly 1/50 60 min, RT pH 9.0, WB, 95°C, 20 min Zytomed Polymer HRP H. Reis et al: Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas Supplementary Table 2) Composition of the non-liver tumor TMA Diagnosis n % ADC 11 2.9 ADC Adenocarcinoma of the lung Carc. -
Nipple-Areolar Complex:Diagnostic Challenges
Nipple-areolar complex:diagnostic challenges. Poster No.: C-1547 Congress: ECR 2014 Type: Educational Exhibit Authors: S. Manso Garcia1, S. Plaza Loma2, Y. Rodríguez de Diego1, V. Zurdo de Pedro1, R. Pintado Garrido1, E. Villacastin Ruiz1, M. Moya de la Calle1, M. J. Velasco Marcos1, H. Calero1; 1Valladolid/ ES, 2Valladolid, VA/ES Keywords: Inflammation, Hyperplasia / Hypertrophy, Biopsy, Ultrasound, Mammography, Breast DOI: 10.1594/ecr2014/C-1547 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to third- party sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. www.myESR.org Page 1 of 12 Learning objectives We describe normal anatomy and clinical and radiological findings of nipple-aerolar complex (NAC) disorders. -
Juvenile Fibroadenoma with Features of Phyllodes Tumor
Human Pathology: Case Reports (2015) xx, xxx–xxx http://www.humanpathologycasereports.com Juvenile fibroadenoma with features of phyllodes tumor showing intraductal growth and prominent epithelial hyperplasia in an 11-year-old girl☆ Jun Miyauchi MD a,b,⁎, Fumiko Yoshida MD c, Seiya Akatsuka MD b, Miwako Nakano MD c aDepartment of Pathology and Laboratory Medicine, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba-ken, Japan 272-8513 bDepartment of Clinical Laboratory, Saitama City Hospital, Saitama, Saitama-ken, Japan 336-8522 cDepartment of Pediatric Surgery, Saitama City Hospital, Saitama, Saitama-ken, Japan 336-8522 Received 3 March 2015; revised 26 June 2015; accepted 7 July 2015 Keywords: Abstract Breast tumors in children are uncommon, with the majority of them being adult-type fibroadenoma Juvenile fibroadenoma; (FA). We report a case of juvenile FA (JFA) with features of a benign phyllodes tumor (PT) in an 11-year-old Phyllodes tumor; girl, showing very unusual intraductal/intracystic growth. The tumor was located at the outer peripheral Intraductal papilloma; portion of the right breast apart from the nipple. Histologically, the tumor showed extensive leaf-like Intraductal growth; papillary structures with a broad fibrous stroma, protruding into multiple contiguous cystic spaces lined by Pediatric breast tumor flat ductal epithelium, and closely resembled PT but the stroma of the tumor was only slightly cellular, showing no nuclear atypia and very few mitotic figures. In contrast, epithelial cells covering the fronds exhibited marked hyperplasia, forming a thick multilayered epithelium. The histology of the tumor with intracystic papillary structures and epithelial hyperplasia showed some similarities with intraductal papilloma (IDP).