Ca rcer Research VOLUME 52 9NUMBER 24 9INDEX ISSUE 9CNREA8 ~ PP 6999-7074

CONTENTS

INDEX TO VOLUME 52

6999 Author Index

7019 Subject Index

i Contents of Volume 52

xxi Cover Illustrations for Volume 52

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.

Officers President, Lee W. Wattenberg President-Elect, Margaret L. Kripke Treasurer, Thomas J. King Executive Director, Margaret Foti

Board of Directors Until 1993 June L. Biedler Nancy H. Colburn John Mendelsohn Peter C. Nowell Until 1994 John S. Lazo Lance A. Liotta Sharon B. Murphy Eric J. Stanbridge Until 1995 Curtis C. Harris Victor Ling John D. Minna Kenneth Olden Ex Officio Carlo M. Croee Margaret Foti Thomas J. King Margaret L. Kripke Harold L. Moses Lee W. Wattenberg I. Bernard Weinstein

We are pleased to acknowledge the work of Diana F. Certo, who prepared the author index.

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. Contents of Volume 52

January 1, Number 1

1 Relationship of Prediagnostic Serum Levels of Dehydroepiandres- 95 Identification of the Major Protein Components in Breast Secre- 173 ras Transformation of Simian Virus 40-immortalized Rat Hepa- terone and Dehydroepiandrosterone Sulfate to the Risk of Devel- tions from Women with Benign and Malignant Breast Diseases. tocytes: An in Vitro Model of Hepatnearcinogenesis. Xian-Jun oping Premenopausal Breast Cancer. Kathy J. Hclzlsouer, Gary B. Luis M. S~inchez. Francisco Vizoso, Irene Diez-ltzm and Carlos Fang, Michele Flowers, Armand Keating, Ross Cameron, and Gordon, Anthony J. Alberg, Trudy L. Bush, and George W. Lfpez-Otin. Morris Sherman. Comstock. 181 Characterization of the Antigen (CAKI) Recognized by Monoclo- 101 Preclinical Evaluation of Bryostatin as an Anticancer Agent 5 Activation of the gadd153 Promoter by Genotoxic Agents: A Rapid nal Antibody KI Present on Ovarian Cancers and Normal against Several Murine Tumor Cell Lines: In Vitro versus in Vivo and Specific Response to DNA Damage. Jennifer D. Luethy and Mesothelium. Kai Chang, Lee H Pal, Janendra K. Batra, Ira Activity. Ronald L, Hornung. John W. Pearson. Margaret Nikki J. Holhrook. Pastan, and Mark C. Willingham Beckwith, and Dan L Longo. i I Abundance of the Primary Transcript and Its Processed Product 187 Increased Sensitivity of Human Keratinocytes Immortalized by of Growth-related Genes in Normal and Leukemic Ceils during 108 Quantitation of Thymidylate Syuthase, Dihydrofolate Reductase, Human Papillomavirus Type 16 DNA to Growth Control by Proliferation and Differentiation. Scrg~o Ferrari, Enrico Tagliafico, and DT-Diaphorase Gene Expression in Human Tumors Using Retinoids. Lucia Pirisi, Ayse Balova, G. Ronald Jenkins, John R. Rossella Manfredini, Alexis Grandc, Elena Rossi, Patrizia the Polymerase Chain Reaction. Tetsuro Horikoshi. Kathleen D. Hodam, and Kim E. Creek. Zucchini, Giuseppe Torelli, and Umberto Torelli. Danenberg, Thomas H. W. Stadlbauer. Matthias Volkenandt, 194 Comparative Study of Doxorubicin, Mitoxantrone, and Epirabicin Luke C. C. Shea, Karl Aigner. Bengt Gustavsson. Lawrence in Combination with ICRF-187 (ADR-529) in a Chronic Cardi- 17 Energy-dependent Processes Involved in Reduced Drug Accumu- Leichman, Roland Frosing, Margaret Ray. Nell W. Gibson, otoxicity Animal Model. Patricia M. Alderton, Janet Gross, and lation in Multidrug-resistant Human Lung Cancer Cell Lines C. Paul Spears, and Peter V. Danenberg. without P-Glycoprotein Expression. Carolina H. M. Versantvoort, Michael D. Green. Henricus J. Broxterman, Herbert M. Pinedo, Elisabeth G. E. 117 Interaction of Photodynamic Treatment and Either Hypecthermia 202 Specific Binding to Protein Kinase C by Ingenol and Its Induction de Vries, Nicole Feller, Catharina M. Kuiper, and Jan Lankelma. or Ionizing Radiation and of Ionizing Radiation and Hyperthermia of Biological Responses. Clare M. Hasler, Geza Acs, and Peter M. 24 Neuropeptide Signal Transduction in Lung Cancer: Clinical Im- with Respect to Cell Killing of L929 Eibroblosts, Chinese Hamster Biumberg. plications of Bradykinin Sensitivity and Overall Heterogeneity. Ovary Ceils, and T24 Human Bladder Carcinoma Cells. Carla Prinsze, Louis C. Penning, Tom M. A. R. Dubbelman. and John 209 Relative Activity of Structural Analogues of Amsacrine against Paul A. Bunn, Jr., Daniel Chart, David G. Dienhart, Russell Human Leukemia Cell Lines Containing Amsacrine-sensitive or Tolley, Maureen Tagawa, and Philip B. Jewett. VanSteveninck. -resistant Forms of Topoisomerase I1: Use of Computer Simulations in New Drug Development. Leonard A. Zwelliug, 32 Expression of Human O%Methylguanine-DNA Methyltransfer- 121 lmmunotherapy of Human Glioma Xenografts with Unlabeled, use in a DNA Excision Repair-deficient Chinese Hamster Ovary Michael J. Mitchell, Patricia Satitpunwaycha, Janice Mayes, J311-, or J)Sl-labeled Monoclonal Antibody 425 to Epidermal Elizabeth Altschuler, Michael Hinds, and Bruce C. Bagulcy. Cell Line and Its Response to Certain Alkylating Agents. Zining Growth Factor Receptor. Hans Bender, Hiroshi Takahashi, Koji Wu, Chung-Leung Chan, Alan Eastman, and Edward Bresnick. Adachi, Paul Belser, Shaohong Liang. Marie Prewett, Martin 36 Intracellular Metabolism of 5-Formyl Tetrahydrofolate in Hnman Schrappe, Arne Sutter, Ulrich RodecL and Dorothce Herbn. Breast and Colon Cell Lines. Donna M. Boatman and Carmen J. Allegra. 127 Immunoconjugates Containing Novel Maytansinoids: Promising Anticancer Drugs. Ravi V. J. Chari, Bridget A. MartelL Jonathan L. 45 Molecular Dosimetry of Urinary Aflatoxin-DNA Addncts in Peo- Gross, Sherrilyn B. Cook, Sudhir A. Shah, Walter A. BI/iUler, Adrances in Brief ple Living in Guangxi Autonomous Region, People's Republic of Sara J. McKenzie. and Victor S. Goldmacher. China, John D. Groopman, Zhu Jiaqi, Paul R. Donahue, Anthony 218 Altered p53 Gone Structure and Expression in Human Epithelial PikuL Zhang Lisheng, Chert Jun-shi, and Gerald N. Wogan. Cells after Exposure to Nickel, L. Ma-~hie~ R. A. Mctcalf, 132 Antitnmor Effect of 2'-Deoxy-5-fluorouridine Conjugates against D. Ryberg. W. P. Bennett. C C. Harris. and A. Haugen. 53 High Levels of Enhanced Reactivation of Herpes Simplex Virus a Murine Thymoma and Colon Carcinoma Xenografts. Kenia G. 222 Suppression of Acute Lymphoblastic Leukemia by the Human in Skin Fibroblasts from Various Hereditary Cancer-prone Krauer. lan F. C. McKenzie. and Geoffrey A, Pietersz Wild-Type p53 Gone. Jian Cheng. Jiing-Kuan Yee, Jo Yeargin, Syndromes. Peter J. Abrahams, Ado Houweling, and Alex J. Theodore Friedmann. and Martin Haas. van der Eb. 138 Melphalan Penetration of the Blood-Brain Barrier via the Neutral Amino Acid Transporter in Tumor-bearing Brain. Eain M. 227 Antitumor ActMty of Basic Fibroblast Growth Factor-Saporin 58 Nitrorednetases and Glutathione Transferases That ACt on 4- Mitotoxin in Vitro and in Vivo. Julie G. Beitz, Pamela Davol, Nitroquinoline 1-Oxide and Their Differential Induction by Bu- Cornford. Deborah Young, James W. Paxton, Graemc J. Finla). tylated Hydroxyanisola in Mice. L Stcven Stanley, J. Lyndal York. William R. Wilson, and William M. Pardridge. Jeffrey W. Clark, Junji Kato. Maria Medina, A. Raymond and Ann M. Benson. Frackleton, Jr., Douglas A. Lappi, Andrew Baird, and Paul 144 Intracellular Acidification Is Associated ~ith Enhanced Morpho- Calabresi. 64 Use of Adaptive Control with Feedback to Individualize Suramin logical Transformation in Syrian Hamster Embryo Cells. 231 Topolsomerase Ila and Topoisomerasr ll# Genes: Characteriza- Dosing. Howard I. Scher, Duncan 1, Jodrell, Jacqucline M. Robert A. LeBoeuf. Peiyuan Liu, Gar, Kerckaert. and Eric tion and Mapping to Itumau Chromosomes 17 and 3, Respectively. Iversen, Tracy Curley, William Tong. Merrill J. Egorin, and Alan Gruenstein. Forresl. K. B Tan. Thomas E. Dorman. Kathleen M. Falls. Thomas D Y. Chung. Christopher K. Mirabelli, Stanle,, T. Crooke. and 149 Persistence of Plalinum-Ammine-DNA Adduces in Gonads and 71 Selective Depletion of Tumor ATP by 2-Deoxyglucose and Insulin, Jen-i Map. Detected by np Magnetic Resonance Spectroscopy. Gregory S. Kidneys of Rats and Multiple Tissues from Cancer Patients. Miriam C. Pottier. Eddie Reed. Charles L. Litterst, David Katz. Karczmar, Jeffrey M. Arbeit, B. James Toy, Anne Speder, and 235; Role of Tamoxifen in the Induction of Hormone-independem Rat Michael W. Weiner. and Shalina Gupta-Burt. Mammary Tumors. Karin C. Fendl and Stephen J. Zimniski.

77 Analysis of the Pvull Restriction Fragment-length Polymorphism 154 Effect of ~3 and ~6 Fatty Acids on Transformation of Cultured and Exon Strncture of the Estrogen Receptor Geae in Breast Cells by Irradiation and Transfection. Mareyuki Takahashi, Cancer and Peripheral Blood. Lauren Yaich, William D. Dupont, Marek Ptzetakiewicz, Augustine Ong. Carmia Borek. and John M. Douglas R. Cavorter, and Fritz F. Purl Lowenstein. 238 Announcements 84 Human Colon Adenocareinoma Cell Lines Display Infrared Spec- 163 Enhanced Levels of Annexins in Pancreatic Carcinoma Cefis of Eighty-Third Annual Meeting of the AACR troscopic Features of Malignant Colon Tissues. Basil Rigas and Syrian Hamsters and Their Intrapanereatic Allografts. AACR Special Conferences in Cancer Research Patrick T, T. Wong. Krishnanand D. Kumble, Masahiko Hirota. Par, iz M. Pour, and Future Annual Meetings of the AACR 89 Localization of Radiolabeled Antimyeloid Antibodies in a Human Jamboor K. Vishwanatha. Calendar of E',ents Acute Leukemia Xenograft Tumor Model. Richard H. C. van der Jagt, Christopher C. Badger, Frederick R. Appelbaum. Oliver W. 168 Morphological Reversion of sis-transformed NIH3T3 Cells by 240 Instructions for Authors Press. Dana C. Matthcws. Janet F. Eary, Kenneth A. Krohn, and Trichostatin A. Kenji Sugita, Kenzo Koizumi. and Hiroshi Irwin D. Bernstein. Yoshida,

January 15, Number 2

Perspectives in Cam'er Research 285 Loss of Heteroz)gosity at the Ilnman RAPIA/Krev-I l~cas Is a 328 Mechanism of Cross-Resistance to a Camptothecin Analogue Rare Event in Colorectal Tumors. Joanne Young. Jeffrey Searle. (CPT-II) in a ttuman Ovarian Cancer Cell Line Selected b) Cisplatin. Shigeki Niimi, Kazuhiko Nakagawa, Yoshikazu 249 The Origin of Point Mutations in Human Tumor Cells. Bernard Russell Sfitz. Alistair Co'xen. Michael Ward. and Georgia Sugimoto. Kazuto Nishio, Yasuhiro Fujiwara. Shiro Yoko)ama. S. Strauss. Chenevix-Trench. Yoshiteru Terashima. and Nagahiro Saijo. 290 17,8-Hydroxysteroid Dehydrogenase Gone Espression in Iluman Breast Cancer Cells: Regulation of Expression by a Progestin. 334 Inhibition of DNA Synthesis and Growth in Ituman Breast 254 Cigarette Smoking and Cancers of the Renal Pelvis and Ureter. Matti Poutanen, Bruno Moncharmont. and Reiju Vihko. Stromal Cells b) Bradvkinin: Evidence for Independent Roles of Joseph K. McLaughlin. Debra T. Silverman, Ann W. Hsing. BI and B2 Receptors in the Respective Control of Cell Growth and Ronald K. Ross, Janet B, Schoenberg, Mimi C. Yu, Annette 295 Growth Inhibition of Transforming Growth Factor fl on Iluman Phospholipid Itydrol)'sis. Kiyai V. Patti and Michael P. Sorrel. Stemhagen, Charles F, Lynch, William J. Blot, and Joseph F. Gastric Carcinoma ('ells: Receptor and Postreceptor Signaling. Fraumeni. Jr. Masanori ho. Wataru Yasui, Eikai Kyo. Hiroshl Yokozaki. 341 Transforming Growth Factor-a Acts as an Autocrine Growth Hirofumi Nakayama. Hisao ho. and Eiichi Tahara Factor in Olarian Carcinoma Cell Lines. Kurt Stromhcrg. 258 Proliferation-linked Regulation of Type II IMP Dehydrogeuase Theodore J. Collins IV, Alfred W. Gordon, Carobn L. Jackson. Gone in Human Normal Lymphocytes and IIL~0 Leukemic Cells. 301 Characterization of Platelet-derbed Growth Factor and Platelct- and Gibbes R. Johnson. Masami Nagai. Yutaka Natsumeda, and George Weber. derived Grov.th Factor Receptor Espression in Asbestos-induced Rat Mesothelioma. Che~'l Walker. Edilberto Bermudez. Wend~ 262 The Effects of Interleukin 2 and a-interferon Administration on Stewart. James Bonncr, Christopher J. Mollo~, and Jcl'/ie) E~eritt. 348 Molecular and Cellular Characterization of Iluman Renal Cell Hepatic Drug Metabolism in Mice. Sherry S. Ansher Raj K. Purl Carcinoma Cell Lines. P. Angiard, E. Trahan. S. Liu, F. Latitl Walter C. Thompson. and William H. HaNg. 307 A General Transcription Initiation Factor, Iluman Transcription M. J. Merino, M I. Lerman. B. Zbar, and W, M. Linehan. Factor liD, Overexpressed in ttuman I,uag and Breast Carcinoma 267 Molecular Dosimetry in Rat Urine of Aflatoxin-NLguanine and Other Aflatoxln Metabolites by Multiple Monoclonal Antibody and Rapidly Induced with Serum Stimulation. Chieki Wada, 557 A Quantitative Anal)sis of Tumor-specific Monodonal Antibody Affinity Chromatography and Immunoaffinity/High Performance Kiyoshi Kasai. Tom Kame)a. and ttideki Ohtani. Uptake by Iluman Melanoma Xenografts: Effects of Anfibody Immunological Properties and Tumor Antigen Expression 1,evels. Liquid Chromatography. John D. Groopman, Julia A, Hasler. 314 Complementary DNA Cloning, Messenger RNA Expression, and Laura J. Trudel, Anthon~ PikuL Paul R. Donahue, and Gerald T s R. Shockley, Kc Lin. Cynthia Sung. Janiee A. Nagy. Rona[d G. Induction of a-Class Gluthathione S-Transferases in Mouse Tompkins. Robert L. Dedrick. Harold F. Dvorak. and Marlin L N. Wogan. Tissues, Timo M. Burlier and David L. Eaton. Yarmush. 275 Inhibition of Colon and Breast Carcinoma Cell Growth by' Inter- 319 Isolation and Characterization of a I-B-o-Arabinofnranos)lc)to- leukin-4. Masakazu Tot. Roy BicknelL and Adrian L. Harris. sine-resistant Chinese Ilamster Ovary Cell Mutant That Is Also 367 Spatial Distribution of Tumor-specific Monoclonal Antibodies in 280 Growth Kinetics of Microscopic Hepatocellular Neoplasms in X-Ray ,Sensitive and Is Noncomplementar) ~ith Ataxia Telangi- lluman Melanoma Xenografts. Ty R. Shockley, Ke Lin. Janice A. Carcinogen-resistant and Carcinogen-responsive Strains of Mice. ectasia (;ells, Gloria A. Preston. Helen S. Pa'.nc, and R. Julian Nag',', Ronald G. Tompkins, Martin L. Yarmush, and tlarold F. Thomas D. Pugh and Stanley Goldfarb. Preston. Dvorak.

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. CONTENTS OF VOLUME 52

377 Predicted and Observed Effects of Antibody Affinity and Antigen 428 Increased Growth of NIH/3T3 Cells b) Transfection with Human 474 Rhabdomyosareoma Spheroids with Central Proliferation and Density on Monocloual Antibody Uptake in Solid Tumors. pl20 Complemontary DNA and Inhibition by a pl20 Antiseose Differentiation. Ulrich Karbach, Claus-Dieter Gerha~, Karlfried Cynthia Sung, Ty R. Shockley, Paul F. Morrison, Harold F. Construct. Laszlo Perlaky. Benigno C. Valdez, Rose K. Busch, Groebe. Helmut E. Gabbert. and Wolfgang Mueller-Klieser. Dvorak. Martin L. Yarmush. and Robert L. Dedrick. Robert G Larson. Siss~ M. Jhiang. Wet Wet Zhang, Michael Brattain. and Harris Busch. 478 Effect of Protein Tyrosine Phosphatase 1B Expression on Trans- 385 la Vitro Apoptosis in the Human Hepatoma Cell Line Induced formation by the Haman neo Oecogeoe. Sheryl Brown,Shimer, by Transforming Growth Factor ill. Jen-Kou Lin and Chen-Kung 437 The NZB Mouse us u Model for Chronic Lymphocytic Leukemia. Korea A. Johnson. David E. Hill, and Arthur M. Bruskin. Chou. Joy A. Phillips, Kumudini Mehta. Cesar Fernandez. and Elizabeth S. Ravechb. 389 Eosiuophils~ Tissue Eosiuophilin, and Eosinophil-derived Trans- 483 Inhibition of Estrogen Receptor Action by a Naturally Occurring forming Growth Factor a in Hamster Oral Carcinogenesis. Variant in Human Breast Tumors. Suzanne A. W. Fuqua, Saundra 444 prolonged Decrease of Serum Calcium Concentration by Marine Mohammad Ghiabi, George T. Gallagher. and David T. W. D. Fitzgerald, D. Craig Anred, Richard M. EIledge, Zafar Nawaz, -y-Interferon in Hypercalcemic, Human Tumor (EC-Glbbeoring Wang. Donald P. McDonnell, Bert W. O'Malley, Geoffrey L. Greene, Nude Mice. Kanji Sato, Tomoko Sarah, Kazuo Shizume. Yukiko and William L. McGuire. 394 Human Xeuografl-Nude Mouse Model of Adoptive lmmonother- Yamakawa, Yoshiyuki ann, Hiroshi Demura, Takuhiko Akatsu. apy with Human Meluaoma-specific Cytotoxic T-Cells. Nancy J. Naoyuki Takahashi. and Tatsuo Soda. 487 Interstitial Fluid Pressure In Solid Tumors following Hypecther- Crowley, Carol E. Vervaert, and Hilliard K Settler. 450 Pheochromocytomas and C-Cell Thyroid Neoplasms in Trans- mia: Possible Correlation with Therapeutic Response. Michael 4100 Anticuacer Effects of Eeee Polyunsaturated Fatq.' Acids iu an Oily genie c-runs Mice: A Model for the Haman Multiple Endocrine Leunig, Alwin E. Goetz, Marc Dellian, Gerd Zetterer, Fernando Lymphographic Agent following lotrahepatic Arterial Administra- Neoplasia Type 2 Syndrome. Nicholas Sehulz. Friedrich Propst. Gamarra, Rakesh K. lain, and Konrad Messmer. tion to a Rabbit Bearing VX-2 Tumor. Yoshiki Hayashi, Shoji Michael P. Rosenberg, R. liana Linnoila. Richard S. Paules, Fukushima, Shuichi Kishimoto, Taken Kawaguchi, Mitsuhiro Robert Kovatch. Yuko asian, and George Vande Woude. 491 Involvement of BCL-2 in Glococortieoid-induced Apoptosis of Numata, Yoshihiro lsoda, lira Hirano, and Masahiro Nakano. Human Pre-B-Leukemias. Emad S. Alnemri, Teresa F. Fernandes, 456 Leokoregulin and -r-Interferon Inhibit Human Papillomavirus Subrata Haldar, Carlo M. Croce, and Gerald Litwack. 406 Establishment of a Human t( 4;l l ) Leokemia in scverc Combined Type 16 Gene Transcription in Human Papillomavirus-immortal- Immuuodeficient Mice and Successful Treatment Using Anti- ized Human Cervical Cells. Craig D. Woodworth, Ulrike Lichti, CDI9 (B43)-Pnkewced Antiviral Protein Immonotoxin. Burkhard Scott Simpson, Charles H. Evans, and Joseph A. DiPaolo, Jansen, Fatih M Uckun, Waclaw B. Jaszcz. and John H. Kersey. 464 Nentrophil Chemotactic Factors Produced by u Cell Line from 496 Announcements 413 Protection from l-B-D-Arabiuofurauosylcytosine-indeced Alope- Thyroid Carcinoma. Minoru Yoshida, Hiromilsu Matsazaki, Eighty-Third Annual Meeting of the AACR cia by Epidermal Growth Factor and Fibroblast Growth Factor in Kenmei Sakata. Motohiro Takeya, Kazuharu Kato. Seiichi AACR Special Conferences in Cancer Research the Rat Model. Joaquin J, Jimenez and Ariel A. Yunis. Miznshima. Makoto Kawakita, and Kiyoshi Takatsuki. Future Annual Meetings of the AACR General Motors Cancer Research Foundation Seeks 416 Glycosphingolipids of Various Human Ovarian Tumors: A Signif- Nominations for Annual Journalism Prizes icantly High Expression of PSOjGaICer and Lewis Antigen in Recent Deaths Meciuous Cystadenocarciuoma. Kazushige Kiguchi, Kiyoshi Calendar of Events Takamatsu, Jan Tanaka, Shiro Nozawa, Mason Iwamori, and Advancz, s in Brief Yoshitaka Nagai, 498 Errata 470 Different Effects of Staurosporine, an Inhibitor of Protein Kinases, Z-F. Chang et al., 51." 4724-4728, 1991. 422 Detection of Nuclear Matrix Proteins in Serum from Cancer on the Cell Cycle and Chromatin Structure of Normal and Leu- M. Okoshi et al.. 51: 6019-6024. 1991. Patients. Thomas E. Miller, Lee A~ Beausang. Lisa F. WinchelL kemic Lymphatics, Silvia Bruno. Barbara Ardelt. Janusz S. and Graham P. Lidgard Skierski, Frank Traganos, and Zbigniew Darzynkiewicz. 499 Author Index

February I, Number 3

PERSPECTIVES IN CANCER RESEARCH 593 Heterogeneity of Progesterone Receptor Content and Remodeling 688 Neoplastic Progression by EJ ras at Different Steps of Transfor- by Tamoxifen Characterize Subpepulations of Cultured Human mation in Vitro of Human Uroepitbelial Cells. Carol I. Pratt, 501 Many Growth Factors May Not Be Growth Factors. Richmond Breast Cancer Cells: Analysis by Quantitative Dual Parameter Chinghai Kao, Shi-Q Wu. Kennedy W. Gilchrist. Ryoichi Oyasu, T. Prehn. Flow Cytometry. Mark L. Graham IL Jeffrey A. Smith, Phillip B. and Catherine A. Reznikoff, Jewett. and Kathryn B. Horwitz. 696 Reduced Growth Rate of Dimethylhydruzine-indeced Colon Tu- mors in Rats. Akira Tsunoda, Miki Shibusawa, Yuko Tsunoda, 6~3 Clinical Pharmacokineties of the Anthrapyrazole CI-941: Factors Naokuni Yasuda, and Tadashi Koike. Compromising the Implementation of a Pharmaeokiuotically Guided Dose Escalation Scheme. M A. Graham, D. R Newelk 701 Inhibition of Invasion and Metastasis in Cells Transfected with B. J. Foster, L. A. Gumbrell, K. E. Jenns, and A. H. Calvert. an Inhibitor of Metalloproteinases. Yves A. DeClerck, Norma 508 Prolonged Inhibition by X-Rays of DNA Synthesis in Cells Ob- Perez. Hiroyuki Shimada, Thomas C. Boone. Keith E. Langley. taiuod by Transformation of Primary Rat Embryo Fibroblasts and Shirley M. Taylor. with Oncogenes H-cos and v-myc. Ya Wang and George Iliakis. 610 Novel Compounds Inhibit Estrogen Formation and Action. Claude Labrie. C~line Martel. Jean-Marc Dufour, Charles L~vesq ue, Yves 709 Synthesis and Evaluation of Fiuoromycim A Novel Fluorescence- 515 The Human Prostatic Carcinoma Cell Line LNCaP Expresses Mb~rand. and Fernand Labrie. labeled Derivative of Talisomycin S~o~. Jehangir S, Mist~', Jitesh Biologically Active, Specific Receptors for Ic~,25-Dihydroxyvi- P. Jani. Geoffrey Morris, Ratnakar B. Mujumdar, lan J. Reynolds. tamin Dj, Gary J, Miller, Gary E. Stapleton. Janet A. Ferrara, M. 616 Examination of the Oneogenic Potential of a Tumor-associated Said M. Scbti. and John S. Lazo. Scott Lucia. Stephen Pfister, Tammy E Hedlund. and Prakash Antigen, Intestinal Alkaline Phosphatase, in HeLa x Fihroblest Upadhya. Cell Hybrids, Kathryn M, Latham and Eric J. Stanbndge. 719 Measurement of Thymidiuo Replacement in Patients with High Grade Gliomas, Head and Neck Tumors. and High Grade 521 Pediatric Phase I Trial, Pharmacokinetic Study, and Limited Sarcomas after Continuous Intravenous Infusions of 5- 623 Blocking Effect of Human Serum but not of Cerebrospiual Fluid Sampling Strategy for Piritrexim Administered on a Low-Dose, Iededeoxyuridine. John A. Cook. Joseph Glass, Robert Lebovics. on Ricin A Chain Immonotoxin Potentiation by Monensin or Intermittent Schedule. Peter C. Adamson, Frank M. 8alis, James Hunt Bobo, Harvey Pass, Thomas F. DeLaney, Edward H Currier protein-Monensin Conjugates. Carola Candiani, Antonia Miser, Carola Arndt, Robert J. Wells, Andrea Gillespie, Leslie OIdfield, James B. Mitchell, Eli Glatstcin, and Thomas E. Franceschi, Roberto Chignola, Marcella Pasti, Cristina Anselmk Aronson, John S. Penta, Nell J, Clendeninn, and David G. Goffman. Poplack. Giuseppina Benoni, Giuseppe Tridente. and Marco Colombatti. 726 Recombinant Interieokin-2 and Lymphokine-activated Killer Cell 525 Overexpresslon of Human Topeisomerase i in Baby Hamster 631 The Chlorinated Pesticide Mirox is a Novel Nonphorbol Ester- Treatment of Advanced Bladder Cancer: Clinical Results and Kidney Cells: Hypersensitivity of Cloual Isolates to Camptothecin. type Tumor Promoter in Mouse Skin. Glenda J. Maser, Sharon Immunological Effects. Gregers Gautier Hermann, Pout Knut R. Madden and James J. Champoux. A. Meyer. and Robert C. Smart. Flemming Geertsen, Hans van der Maase, Kenneth Steven, Claus 533 Cellular Elimination of 2',2'-Difluorndanxyeytidine 5"-Triphos- Andersen, Tage Hald, and Jesper Zeuthen. phatr A Mechanism of Self-Potentiation. Volker Heinemann, 637 Improved Delivery- of Rediolabeled Anti-Bl Monoclonal Antibody Yi-Zheng Xu, Sherri Chubb. AEna Sen, Larry W. Hertel, Gerald to Raji Lymphoma Xeoogrufts by Predosing with Unlabeled Anti- B. Grlndey, and William Piunkett. BI Monocloual Antibody. Donald J. Buchsbaum. Richard L. Wahl, Stephan D. Glenn. Daniel P. Normolle, and Mark S. 540 Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Kaminski ADVANCES IN BRIEF Differentially Alter Hepatic Drug and Steroid Hormone Metabo- lism in Male and Female Rats. Gerald A, LeBlanc, Scott S. 643 Disruption of the .4PC Geuo by a Retrotransposal Insertion of LI 734 p53 Mutations in Non-Smaff Cell Lung Cancer in Japan: Associ- Sundseth, Gears F, Weber, and David J. Waxman. Sequence in a Colon Cancer. Yoshio Miki, Isamu Nishisho, Akira ation between Mutations and Smoking. Hiroko Suzuki, Takashi Takahashi, Tetsuo Kuroishi, Motokazu Suyama, Yutaka 548 Activation and Growth of Murine Tumor-slmcific T-Cells Which Horii, Yasuo Miyoshi, Ioji Utsunomiya, Kenneth W. Kinzler, Ariyoshi, Toshilada Takahashi. and Ryuzo Ueda. Have in Viva Activity with iiryestatin 1. Todd M, Turtle, Thomas Bert Vogelstein, and Yusuke Nakamura, H. Inge, Kevin P Bethke, Cad W. McCrady, George R. Pettit, 737 Protein Tyresine Phosphatase Expression in Pre-B Cell and Harry. D. Bear. 646 In Viva Targeting of OV-TL 3 Immunoliposomes to Ascitic NALM-6. Masaaki Adachi, Masuo Sekiya. Yoshiaki Arimura, Ovarian Carcinoma Cells (OVCAR-3) in Athymic Nude Mice. Mutsuhiro Takekawa, Fumio Itoh, Yuji Hinoda, Kohzoh treat. 554 Endothelin-I Geoe Expression and Biosynthesis in Human En- Ulla K Nassander. Peter A. Steerenberg, Hilde Poppe. Gert and Akira Yacht, dometrial HEC-IA Cancer Cells. Katherine Economos, Paul C. Storm, Lambert G, Pods, Wire H. De long, and Daan J. A. MacDonald, and M. Linette Casey. Crommelin. 741 Loss of Heterozygosity Affecting the p53, Rb, and race/ape Tumor Suppressor Gone Loci in Dyspiastic and Cancerous Ulcerative 558 Mutation(s) of the Thymidylate Syntbase Geoe of Human Ade- Colhis. Bruce D. Greenwald. Noam Harpaz, ling Yin. Ying nocarciuoma Cells Causes a Thymidylate Syntbese-negative Pbe- 654 Failure of RB] to Reverse the Malignant Pbenotype of Human Huang, Yi long, Victoria L Brown. Tim McDaniel, Carnell notype That Can Be Attenuated by Exogenous FoJates. Peter J, Tumor Cell Lines. Michelle M. Muneaster. Brenda L. Cohen. Newkirk. James H. Resau, and Stephen J. Mehzer. Houghton. Atiqur Rahman, Cindy L. Wilt. Bruce J. Dolnick, and Robert A. Phillips, and Brenda L. Gallic. Janet A. Houghton. 746 FL T4, a Nosel Class llI Recegtor Tyrosine Kiuase in Chromosome 5q33-qtec. alga Aprelikova, Katri Pajusola. Juha Partanen, Elina 566 Surface Immunoglobulin-mediated Signal Transduction Involves 662 The Effect of Dietary Fat on the Rapid Development of Mammary Armstrong, Riitta Alitalo. Stacie K. Bailey. Jeannette McMahon. Rapid Phosphoryiation and Activation of the Protooneogeoe Prod- Tumors Induced by 7,12-Dimethylbenz(a)anthrocene in SENCAR John Wasmuth, Kay Huobner, and Karl Alitalo. uct Rof-I in Human B-Cells. Toshiharu Tamaki, Yuzuru Mice. Su~n M. Fischer, Claudia J. Conti, Mary Locniskar, Ma~ha A. Belury, Regina E. Maldve, Marilyn L. Lee. Julius Kanakura, Akira Kuriu, Hirokazu lkeda, Hideki Mitsui, Hirosuke 749 Altered Expression of Wild-Type p53 Tumor Suppressor Gene Leyton, Thomas J. Slaga. and David H. Bechtel Yagura, ltaru Matsumura. Brian Druker. James D, Griffin. during Marine Epithelial Cell Transformation. Kyung-An Han Yoshio Kanayama, and Takeshi Yonezawa. and Molly F. Kulesz-Martin. 667 Individual Transforming Events in Long-Term Cell Culture of 571 Basic Fibroblast Growth Factor in Human Prostate Cancer Cells. NIH 3"!"3 Cells as Products of Epigeoetic Induction, Bryan J. Takahisa Nakamoto. Chawnshang Chang, Ankun Li, and Gerald Ellison and Harry Robin, W. Chodak. 674 p5J Mutation and Loss of Heterozygosit) on Chromosomes 17 578 Hormone Levels in Vegetarian and Nonvegetarian Teenage Gifts: and 10 during Human Astrocytoma Progression. Dan Fulls, 754 Announcements Potential Implications for Breast Cancer Risk. Victoria W. Persky, Douglas Brockmeyer, Micam W. Tullous, Carolyn A. Pedone. Eighty-Third Annual Meeting of the AACR Robert T. Chatterton, Linda V. Van Horn, Mark D. Grant, and Richard M. Cawlhon. AACR Special Conferences in Cancer Research Patricia Langenberg, and Joy Marvin. Future Annual Meetings of the AACR 680 Expression of Simple Epithelial Cytokeratins in Moose Epidermal Recent Death 584 Blood Flow in Six Human Melanoma Xenegraft Lines with Dif- Keratinocytes Harboring Harvey ras Geoe Alterations. Margarita Calendar of Events ferent Growth Characteristics. Heidi Lyng, Arne Skretting, and Diaz-Guerra, Sheena Haddow. Cristina Bauluz. Jose Luis Jorcano. Einar K. Rofstad. Amparo Cano. Allan Balmain. and Miguel Quintanilla. 756 Author Index

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. CONTENTS OF VOLUME 52

February 15, Number 4

EDITORIAL 851 Immunological Effects of Treatment with Sequential Administra- 974 Qanntitative Mapping of 4'-Iododenxyrubicin in Metastatic Squa- tion of Recombimmt Interferon 'y and ce in Patients with Metastatic mons Cell Carcinoma by Secondary Ion Mass Spectrometry 75";' Progress Report on ~Advonces in Brief." Carlo M. Croce. Renal Cell Carcinoma during a Phase 1 Trial. Marc S. Emstoff, (SIMS) Microscopy. Philippe Fragn, Jerzy Klijanienko, Daniel William Gooding, Suresh Nair, Robert R. Bahnson. Linda M. Gandia, Sylvain Halpern, and Jean-Pierre Armand. Miketic, Barbara Banner, Roger Day, Theresa Whitesidc, Linda Titus-Ernstoff, and John M. Kirkwood. 978 Chemically Induced Forestomach Papillomas in Tronsgenic Mice 758 A New Form of Cytuehrome P-450 Responsible for Mutagenic Carry Mutant Human c-Ha-ros Transgenes. Kiyoshi Ando, 857 The Combined Effects of Dietary Fat, Protein, and Energy Intake Activation of 2-Amino-3-methylimidazo[4,54]quinoliue in Human Atsuhiko Saitoh, Okio Hino, Ri-ichi Takahashi, Minoru Kimura, Livers. Kazuyuki Ubukata, Hironki Ohi, Mitsukazu Kitada, and on Azoxymethane-indueed Intestinal and Renal Carcinogenesis. and Motoya Katsuki. Tetsuya Kamataki. Steven K. Clinton, Peter B. lmrey, Heather J. Maogian, Steve Nandkumar, and Willard J. Visek. 983 Control of Ha-ras-modiated Mammalian Cell Transformation by Escheriehln cell Regulatory Elements. Hsiao-Sheog Liu, Heidi 764 Interferon-induced Increase in Sensitivity of Ovarian Cancer Tar- 866 Resistance to Cytolysis by Tumor Necrosis Factor a in Malignant Scrable, Douglas B. Villaret, Michael A. Lieberman, and Peter J. gets to Lysis by Lymphokiue-nctivated Killer Cells: Selective Gynecological Cell Lines is Associated with the Expression of Stambrook. Effects on HER2/neu.-overexpressing Cells. Catherine lady, Protein(s) That Prevent the Activation of Phospholipase A~ by Agnes M. Gardner, Joseph H. Gera, and Alan Lichlenstein. Tumor Necrosis Factor a. David G. Muteh, C. Bethan Powell, 990 Aflatoxin-trnosformed C3H/10TtA Cells Overexpress Protein Ming-Shian Kao, and John Leslie Collins. Kinase C nnd Have an Altered Response to Phorhel Ester Treat- 770 Consistent Association of Ip Loss of Heterozygosity with Pheo- ments. Joseph A. Dunn, Michael B. Faletto, Stevcn J. Kasper, chromocytomas from Patients with Multiple Endocrine Neoplasia 873 Deletion Mapping on the Short Arm of Chromosome 3 in Squa- and Hira L. Gurtoo. Type 2 Syndromes. Jeffrey F. Moley, Michelc B. Brother, Chin- mous Cell Carcinoma and Adenocarcinoma of the Lung. Shiro To long, Peter S. White, Stephen B. Baylin, Barry Nelkin, Samuel Yokoyama, Kazuhiro Yamakawa, Eiju Tsuchiya, Motoi Murata, 997 Microfilament-disrupting Agents Prevent the Formation of A. Wells, and Garrett M. Brodeur. Shigeru Sakiyama, and Yusuke Nakamura. Apoptotic Bodies in Tumor Cells Undergoing Apoptosis. Thomas G. Cotter, Seamus V. Lennon, Jacqueline M. Glynn, 775 Tumor-renctive T.4Zells Accumulate in Lung Cancer Tissues but 878 ci~-Diammiuedichloroplatinum(ll) Induces c-jun Expression in and Douglas R. Green. Fail to Respond Due to Tumor Cell-derived Factor. Ichiro Human Myeloid Leukemia Cells: Potential Involvement of a Yoshino, Tokujiro Yano, Mitsuhiro Murata, Teruyoshi Ishida, Protein Kianse C-dependent Signaling Pathway. Eric Rubin, 1006 Expression of Platelet-derived Growth Factor and Its Receptors Keizo Sogimachi, Genki Kimura, and Kikuo Nomoto. Surender Kharbanda, Hisato Gunji, Ralph Weichselbaum, and in Nenroendocriue Tumors of the Digestive System. Arvind Donald Kufe. Chaudhry, Vasilis Papanicolaou, Kjell Oberg, Carl-Henrik Heldin, and Keiko Funa. 782 Parental Occupation and Childhood Astrueytoma: Results of 883 Rndiatian-indueed Apoptosis in a Morion T-Cell Hybridomo. a Case-Control Study. Ren6 R, Kuijten, Greta R. Bunin, Raymond L. Warters. 1013 Antitumor Effects of SMANCS on Rat Mamnmry Tumor Induced Catharie C. Nass, and Anna T, Meadows. by 7,12-Dimethylbenz[alanthracene. Akihiro Kimoto, Toshimitsu 891 Selective Tumor Localization and Improved Therapeutic Index of Konno, Takanori Kawaguchi, Yoshimasa Miyauchi, and Hiroshi 787 Reversihility of Catechol-induced Rat Glandular Stomach Lesions. Anthracycllnes Encapsulated in Long-Circulating Liposomes. Maeda. Masao Hirose, Shigetsugn Wada, Shuji Yamaguchi, Atsuko Alberto A. Gabizon. Masuda, Shuzo Okazaki, and Nobuyuki tan. 1018 Disseminating Tumor Cells and Their Interactions with Lenko- 897 Flodarabiue Infusion Potentiates Arabioosylcytesiue Metabolism cytes Visualized in the Brain. Lois A. Lampson, Patrick Wen, in Lymphocytes of Patients with Chronic Lymphocytic Leokemla. Victoria A. Roman, James H. Morris, and Jacob A. Sarid. 791 Differential Expression of S19 Ribosomal Protein, Laminin-bind- Varsha Gandhi, Annette Kemena, Michael J. Keating, and ing Protein. and Human Lymphocyte Antigen Class I Messenger William Plunkctt, RNAs Associated with Colon Carcinoma Progression and Differ- entiation. Nobuo Kondoh, Clifford W. Schweinfest. Kelly W. 904 Development of Humoral Immune Responses against a Macro- Henderson, and Takis S. Papas. cyclic Chelating Agent (DOTA) in Cancer Patients Receiving Rndioimmnoueonjugates for Imaging and Therapy. Christos ADVANCES IN BRIEF 797 NAD(P)H:Quinone Oxidoreductase Geue Expression in Human Kosmas. Deborah Snook, Calvin S. Gooden, Nigel S. Courtenay- 1026 Interleukin-9 ls Expressed by Primary and Cultored Hodgkin and Cohm Carcinoma Cells: Characterization of a Mutation Which Luck. Michael J. McCall. Claude F. Meatus* and Agamemnon A. Reed-Sternherg Cells. Hans-Jiirgen Gruss, Marion A, Brach, Modulates DT-Diaphorose Activity and Mitomycin Sensitivity. Epenetos. Hans-Gi.nter Drexler, Klaus J. Bross, and Friedhelm Herrmann. Robert D. Traver, Tetsuro Horikoshi, Kathleen D. Danenberg, 912 Circadian Variation of Tumor Blood Flow in Rat Subentanenus Thomas H. Stadlbauer, Peter V. Danenberg, David Ross, and 1032 Infcequentp53 Mutation in Mouse Tumors with Deregulated myc. Tumors and Its Alteration by Aogiotensin II-induced Hyperien- Nell W. Gibson. Marina L Gutierrez, Kishor Bbatia, David Siwarski. Linda Wolff, sion. Katsuyoshi Hori, Maroh Suzuki. Shigeru Tanda, Sachiko tan T. Magrath, J. Frederic Mushinski, and Konrad Huppi. Saito, Mika Shinozaki, and Qiu-Hang Zhang. 803 Haman Uterine Endometrlal Adenocarcinoma: Characteristic Ac- 1036 Sporadic Amplification of the Insulin-like Growth Factor 1 Re- quirement of Synthetic Potentials for IPSOrLocCer and Ganglio 917 SMS 201.995 Inhibits in Vitro und in Viro Growth of Human ceptor Geue in Human Breast Tumors. Els M. J. J. Betas, Jan G. Series Suffoglycosphingolipids after Transfer of the Cancer Cells Colon Cancer. David Y. Dy, Robert H. Whitehead, and David L. M. Klijn, Iris L. van Staveren, Henk Portengen, and John A. Morris. to Culture. Kaneyuki Kubushiro, Katsumi Tsukazaki, Jun Foekens. Tanaka, Kiyoshi Takamatsu, Kazushige KAgnehi, Mikio MikamL 924 Role of Nenvasculatuce and Vascular Permeability on the Tumor Shirou Nozawa, Yoshitaka Nagai. and Masao Iwamori. 1040 Tumor Promoters Induce Basic Fibroblast Growth Factor Gone Retention of Photodynomic Agents. W. Gregory, Roberts and Expression in Haman Dermal Fibroblasts. Jeffrey A. Winkles, Tayyaba Hasan. 810 Localization of Shed Human Tumor Gangliosides: Association KJmberly A. Peifley. and Robert E. Fries,el. with Serum Lipeproteios. Leonard A. Valentino and Stephan 931 The Combination of 3~-Interferen and Tumor Necrosis Factor 10414 Low Frequency of 1753 Gene Mutation in Tumors Induced by Ladisch. Causes n Rapid and Extensive Differentiation of Human Aflatoxin B~ in Nonhuman Primates. Yoshinori Fajimoto, Neuroblastoma Cells. Mirco Ponzoni, Antonella Casalaro. Lon L. Hampton, Lin-di Loo, Peter J. Wirth, and Snore S. 815 Baculovirus Recombinant Expressing a Secreted Form of a Trans- Marina Lanciotti, Paolo Giuseppe Montaldo. and Paolo Thorgeirsson. membrane Caeeinoma-asser Antigen. Christian P. Strassburg, Cornaglia-Ferraris. Yasushi KasaJ, Beth A. Sung. Pierre Minion, Jan Zaloudik, Dorothee Herlyn, Hilary Koprowski, and Alban J. Linnenbach. 940 lntrodnction of the ms Oueogene Transforms a Simian Virus 40- immortalized Hepntueyte Cell Line without Loss of Expression of 822 Ammine/Amine Platinum(IV) Dicarboxylntes: A Novel Class of Albumin and Other Liver-specific Genes. Harriet C. Isom, Platinum Complex Exhibiting Selective Cytotoxicity to Intrinsi- Craig D. Woodworth. Yunlian Meng. John Kreider, Thomas LETI'ER TO THE EDITOR tally Cisplatin-cesistant Human Ovarian Carcinoma Cell Lines. Miller. and Loft Mengel. 1047 Correspondence re: R. Grundel and H. Rubin, Effect of Interclonal Lloyd R. Kelland, Barry A. Morrer, George Abel, Christen M. 949 Changes in Microtubules* Microtubule-ossoclated Proteins, and Heterogeneity on the Progressive, Confluence-mediated Acquisi- Giandomenico, Prakash Mistry, and Kenneth R. Harrap. Intermediate Filaments during the Differentiation of HL-60 Len- tian of the Focus-forming Phenotype in NIH-3T3 Populations. kemia Cells. Mun-Fai Leung, John A. Sokoloski. and Alan C. Cancer Res., 51:1003-1013. 1991. Seymour J. Garte. Reply by 829 Identification of a Human Tumor-derivod Lipolysis-prnmotiog Ralph Grundel and Harry. Rubin. Factor. Douglas D. Taylor, Cicek GereeI-Taylor, Louis G. Jenis, Sartorelli. and Dennis F. Devereux. 955 Ploidy and Specific Karyotypic Changes during Promotion with Phenobarbital, 2,5,2',5'-Tetrachlorobiphenyl. and/or 3,4,3',4"- 835 The Fate nf Antibodies Bound to the Surface of Tumor Cells in Tetraehlorobiphenyl in Rut Liver. Linda M. Sargent. Gerald L. Vitro. Raymond J. Kyriakos, Lisa B. Shih. Gaik Lin Ong, Kirti Sattler. Boyd Roloff, Yi-hua Xu, Carol A. Sattler, Lorraine 1051 Announcements Patel. David M. Goldenberg, and M. Jules Mattes. Meisner. and Henry C. Pitot. Eighty-Third Annual Meeting of the AACR AACR Special Conferences in Cancer Research 843 Molecular Heterngeneity of Somntostntin Anologue BIM-23014C 963 Quantitative Ultrastcectaral Effects of Cisplatin (Platinol), Future Annual Meetings of the AACR Receptors in Human Breast Carcinoma Cells Using the Chemical Carheplatin (JM8), and Iproplatin (JM9) on Neurons of Fresh- Recent Death Cross-Linking Assay. Gr~oir~ Pr6vost, Monique Lanson, water Snail L vmuen stngnalis. Linda J. Muller. Carry M. Calendar of Events Franfois Thomas, Nathalie Veber, Walter Gonzalcz, Ren~ Moorer-van Delft, Eric W. Roubos. Jan B. Vermorken. and Beaupain, Anna Starzec, and Arthur Bogden. Harry H. Boer. 1053 Author Index

March 1, Number 5

EDITORIAL 1087 Interferon-stimulated Genes in Interferon-sensitive and -resistant 1129 Cellular Interactions in Effector Cell Generation and Tumor Regres- Chronic Myelogenous Leukemia Patients. Moshe Talpaz, Yuti sion Mediated by Anti-CD3/lnterlenkin 2-activated Tumor-draining 1055 Progress Report on "Advonces in Brief." Carlo Crone. M. Chernajovsky, Karla Troutman-Worden, Muir Wetzler, Hagop Lymph Node Cells. Hirohisa Yoshizawa, Alfred E. Chang, and Suyu Kantarjian, Jordan U. Guttcrman. and Razelle Kurzrock. Shu. 1091 Influence of Intracellular Glutathioue on Selenite-mediated Growth 1137 Human Lymphoblastoid Cells with Acquired Resistance to CL Inhibition of Canine Mammary Tumor Cells. Matthew J. Kuchan Desamino-C2-methyl-Nt%prnpargyl-5,8-dideazofolic Acid: A Novel and John A. Milner. Folate-hased Thymidylute Synthase Inhibitor. Brigld M. O'Connor. REVIEW Ann L. Jackman, Philip H. Crossley, Sarah E. Freemantle. John 1096 No Change in Repair Capacity of Mouse Lung Irradiated Three Lunec, and A. Hilary Calvert. 1056 Mechanism of Interferon Action in Hairy Cell Leukemia: A Model Months after a Single Dose of Cyclophosphamide. M. T. Pouzet and of Effective Cancer Biotherapy. Suresh Vedantbam, Haim GamlieL E. L. Travis. 1144 Expression of O6-Methylguaniue-DNA Methyltransferase in Six and Harvey M. Golomb. Human Mednlloblastoma Cell Lines. Xuanmin He, Lawrence E. 1101 Cellular Mechanisms Associated with the Lack of Chronic Thermo- Ostrowski, Mathew A. von Wronski, Henry S. Friedman. Carol J. tolerance Expression in HeLa $3 Cells. Michael A. Mackey, Wikstrand, Sandra H. Bigner, Ahmed Rasheed, Surinder K. Batra, Steven L. Anolik. and Joseph L. Roti Roti. Sankar Mitra. Thomas P. Brunt, and Darell D. Bigner. 1107 c-mye Amplification Is u Better Prognostic Factor than HER2/nen 1149 Biotronsformation in Carcinogen-induced Diploid and Polyploid He- 1067 Therapeutic Advantage of High-Affinity Anticarcinoma Radioim- Amplification in Primary Breast Cancer. Els M. J. J. [gems, patorytes Separated by Centrifugal Elulrlation. John B. Watkins IIL munoconjugates. Jeffrey Sehlom, Diane Eggensperger, David Jan G, M. Klijn, Wire L. J. van Putten. lris L. van Staveren. Hunk D. Thierau, and Leslie R. Sehwarz. Colcher, Alfredo Molinolo, David Houchens, Larry S. Miller, George Portengen, and John A. Foekens. Hinkle, and Kathleen Slier. 1155 Immunotherapy of Marine Renal Adenocareinoma by Systemic Ad- 1114 Characterization of Functional Receptors for Gastrointestinal Hor- ministration of Liposomes Containing the Synthetic Macrophege mones on Haman Colon Cancer Cells. H. Frucht, A. F. Gazdar, J-A. Activator CGP 31362 or CGP 19835A in Combination with Interleu- 1073 Cooperative Estrogen Receptor Interaction with Consensus or Var- Park, H. Oie, and R. T. Jensen. kin 2 or ~'-Interferon. Colin P. N. Dinney, Teruhiro Utsugi, Isaiah J. iant Estrogen Responsive Elements in Vitro. Carolyn M. Klinge, Fidler. Andrew C. yon Eschenbach, and lerald J. Killion. 1123 Cytokiue Responses to Intraventrieular Injection of Interleukin 2 into Franklin V. Peale, Jr.. Russell Hill', Robert A. Bambara, and Sayeeda Patients with Leptomeniugcal Carcinomatosis: Rapid Induction of 1162 Inhibitory Effect of Green Tea in the Drinking Water on Tumorigen- Zain. Tumor Necrosis Factor a, Interleukin IB, Interleukin 6, 3'-Interferon, esis by Ultraviolet Light and 12-O-Tetrndecanoylphorhel-i 3-acetate and Soluble Interleukin 2 Receptor (M, 55,000 Protein). J. List, in the Skin of SKH-I Mice. Zhi-Yuan Wang. Mou-Tuan Huaog. 1082 Mutaganic Specificity of Oxygen Radicals Produced by Haman R. P. Moser, M. Steuer, W. G. Loudon, J. B, Blacklock, and Thomas Ferraro, Ching-Quo Wong, You-Rong Lou, Kenneth Reuhl. Leukemia Cells. Thomas M. Reid and Lawrence A. Loeb. E. A. Grimm. Michael latropoulos, Chung S. Yang, and Allan H. Conney.

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1171 Effect of Or-Benzylguanine on the Sensitivity of Human Tumor 1235 Effectiveness of a Lysyl Chlorin pr/Chlurin p6 Mixture in Photo- 1322 Chromosome Alterations in Human Small Cell Lung Cancer: Fre- Xenografts to 1,3-Bis(2-chloroethyl)-I-nitrusourea and on DNA dynamic Therapy of the Subcutaneous 9L Glioma in the Rat. quent Involvement of5q. lkuo Miura, Stephen L. Graziano, Jin Quan Interstrand Cross-Link Formation. K Brian Mitchell, Robert C Michael W. Leach, Robert J. Higgins, James E. Boggan, Shwn-Ji Cheng, L. Austin Doyle, and Joseph R. Testa. Mosehel, and M. Eileen Dolan. Lee. Susan Autry. and Kevin M. Smith. 1329 Hepatitis B Virus Replication in Well Differenliated Mouse Hepa- Ineyle Cell Lines Immortalized by Plasmid DNA. Shu-Hsia Chen, 1176 Metabolism and DNA Binding of 2-Nitrupyrene in Ihe Rat. Pramed 1240 Anlitumoral and Endocrine Effects of (+)-Vorozole iu Rats Bearing Cheng-po Hu, and Chungming Chang. Upadhyaya. Ajit K. Roy, Peter P. Fu, and Karam EI-Bayoumy. Dimethylbenzanthracene-indaced Mammary Tumors. Roland De Coster. Robert F. Van Ginckel, Myriam J. L. Callens, 1336 Localization of Messenger RNA for M, 72,000 and 92,000 Type IV 1182 Recombinant Human Mullerian Inhibiling Substance Inhibits Hu- Nick K. G. Goeminne, and Boudewijn L. E. Janssens. Coliagenases in Human Skin Cancers by in Situ Hybridization. man Ocular Melanoma Cell Lines in Vitro and in Vivo. Robert L. Charles Pyke, Elisabr Ra]fldaer, Piricko Huhta]a, Tina Hurskainen, Parry, Taiwai Chin, James Epstein, Peter L. Hudson, David M. 1245 Camptothecin Induces Differentiation and Stimulates the Expression Keld Dane, and Karl Tryggvason. Powell, and Patricia K. Donahoe. of Differentiation-related Genes in U-937 Human Promonocytic Leukemia Cells. Palricio Aller, Carlos Rius, Felieisima Mate, Aria 1342 Tumor Necrosis Factor a Induces Apoptosis in Mammary Adeno- 1187 Growth-inhibitory Action of an Estrngen-Chlocambucil Conjugate Zorrilla, Carlos Cabahas, Teresa Bellrn, and Cacmelo Bernabeu. carcinoma Cells by an Increase in Intranuclear Free Ca 2§ Concentra- (KM2210) in Human Breast Cancer Cell Line MCF-7: Its Relation tion and DNA Fragmentation. Giorgio Bellomo, Mariarosa Perotti, Filippo Taddei, Francesca Mirabelli, Giorgio Finardi, Pierluigi Io Reduction of Estrogen Receptor and Transforming Growth Fuctor- 1252 A Rationale for Carbopiatin Tt~atment and Abdominal Hyporthermia Nicotera, and Sten Orrenius. a Secretion. Hiroshi Kosano, Tetsuro Kubota, Nakaaki Ohsawa, in Cancers Restricted to the Peritoneal Cavity. Gerrit Los, Shunji Yamamori, Osahiko Abe, Hirohumi lnagaki, and Naokazu Oskar A. G. Smals. Marianne J. H. van Vugt, Martin van der Vlist, 1347 Site-dependent Differences in Sensitivity of LOX Human Melanoma Negate. Leo den Engelse, J. Gordon McVie, and H. M. Pinedo. Tumors in Nude Rats to Daearhazine and Mitozolomide, but not to Doxorubicln and Cisplatin. Inge Kjenniksen, Knut Breist~l, and 1192 Glutaminase and Glutamine Synthetase Activities in Human Cir- 1259 Nonglycolytic Acidif~ation of Murine Rndiation-induced Fibrosar- ~ystein Fodstad, rhotic Liver and Hepatocellular Carcinoma. Telsuya Matsuno and coma l Tumor via 3-O-Methyl-D-Glucose Monitored by ~H, 2H, J~C, Iori Goto. and JJP Nuclear Magnetic Resonance Spectroscopy. Yuying C. I352 In Vitro and in Vivo Enhancement of Ricin-A Chain Immunotoxin Hwang, Seong-Gi Rim, Jeffrey L, E'~'elhoch, and Joseph J. H. Activity by Novel lndolizine Calcium Channel Blocker~ Delayed 1195 Inhibition of Experimental Metastasis and Cell Adhesion of BI6FI Ackerman. lntzaceBulnr Degrndntion Linked to Lipidosis Induction. Jean-Pierre Melanoma Cells by lnhibitors of Protein Kianse C, Jennifer A. Jaffr~zou, Thierry Levade, Olivier Thurneyssen, Marielle Chiton, Dumont, Winton D. Jones, Jr., and Alan J. Bitonti, 1267 Binding of Aflatoxin B~ Metabolites in Extrahepatic Tissues in Fetal Christine Bordier, Michel Attal, Pierre Chatelain, and Guy Laurent. and Infant Mice and in Adult Mice with Depleted Gletathione Levels. 1201 BrMieroglobulin Gene Is Mutated in a Human Colon Cancer Cell Line (HCI') DeficienI in the Expression of HLA Class I Antigens on Pia Larsson and Hans Tjalve. the Cell Surface. Sebastiano Gattoni-Celli, Katharina Kitsch, Rita ADVANCES IN BRIEF 1278 Differential Effects of Bryostatin 1 and Phorbol Ester on Human Timpane. and Kurt J. Isselbacher. 1360 Induction of Covalent DNA Adducts in Rodents by Tamoxifen. Breast Cancer Cell Lines. M. John Kennedy, Laura J. Prestigiacomo, Xueliang Han and Joachim G. Liehr. 1205 CA54/61 as a Marker for Epithelial Ovarian Cancer. Shiro Nozawa, Greg Tyler, W. Stratford May, and Nancy E. Davidson. Daisuke Aoki, Masazumi Yajima, Katsumi Tsukazaki, Toshibumi 1364 Inverse Relationship between trk Expression and N-m.vc Amplifica- Kobayashi, Eizo Kimura, Yoshiteru Temshima, Noriyuki lnaba, 1284 Effects of Target Antigen Competition on Distribution of Monoclonal tion in Haman Neurobiastomas. Akira Nakagawara, Miwako Arima, Hiroyoshi Takamizawa. Yoshiyuki Negishi, Hisanao Ohkura, Antibody to Solid Tumors. Stephen J. Kennel. Christopher G. Azar, Nancy J. Scavarda, and Garrett M. Brodeur. Hiroshi Sato, and Hiroshi Mochizuki. 1369 Unique Association of p53 Mutations with Undifferenlialed but not 1291 Expression of Calcyclin in Human Melanoma Cell Lines Correlates with Differentiated Carcinomas of the Thyroid Gland. Takashi llo, with Metaslatic Behavior in Nude Mice. Marian A. J. Weterman. 1210 Altered Gene Expression of e-m.vc, Epidermal Growth Factor Recep- Toshio Seyama. Terumi Mizuno, Naohiro Tsuyama, Tomonori Geert M. Stoopen. Goos N. P. van Moijen, Jacek Kuznicki. Dick d. tor', Transforming Growth Factor-~, and c-erb-B2 in an Immortalized Hayashi, Yuzo Hayashi, Kiyohiko Dohi, Nori Nakamura, and Ruiter, and Henri P. J. Bloemers. Human Breast Epithelial Cell Line, HMT-3522, Is Associated with Mitoshi Akiyama. Decreased Growth Factor Requirements. Mogens Winkci Madsen. Anne E. Lykkesfeldt, Inga Laursen, Kirsten Vang Nielsen, and Per 1297 Suppression of Tumorigenicity and Anchorage-independent Growth 1372 Mechanisms of Cell Growth Inhibition and Cell Cycle Arrest in Briand. of BK Virus-transformed Mouse Cells by Human Chromosome 11. Human Colonic Adennearcinoma Cells by Dehydrnepiandrosterone: Massimo Negnni. Antonella Castagnoli, Jorge V. Pavan, Silvia Role of Isnprenoid Biosynthesis. Stefan Schulz, Richard C. Klann. 1218 The Synthetic Hepatic Peptides Pyroglutamylglutamylglyeylserylas- Sabbioni, Diana Araujo, Alfredo Corallini, Francesca Gualandi, Solveig Schonfeld, and Jonathan W. Nyce. pnzagine and Pyroglutamylglutamylglycylseryiaspartic Acid Inhibit Paola Rimessi, Alessandra Bonfatti, Cecilia Giunta, Alberto Sensi, 1377 Partial Purification of a Human DNA Glycosylase Acting on the Growth of MH~CI Rat Hepatoma Cells Transplanled into Buffalo Eric J. Stanbridge, and Giuseppe Barbanti-Brodano. Cyclic Carcinogen Adduct l,N~-Ethenodcoxyadeoosine. B. Rydberg, Rats or Athymic Mice. Jan Erik Paulsen, Kirsten Sundby Hall, Hans 1304 Nuclear Enlargement Induced by Hepntocarcinogans Alters Ploidy. Z-H. Qiu, M. K. Dosanjh, and B. Singer. Erik Rugstad, Karl Ludvig Reichelt, and Kjell Elgjo. Gary A. Clawson, Lori J. Blankenship, Jean G. Rhame, and David S. Wilkinson. 1222 CA 72-4 Measurement of Tumor-assneiated Glycoprutein 72 (TAG- 1380 Announcements 72) as a Serum Marker in the Managemenl of Gastric Carcinoma. 1309 Effect of Tumor Size on the Enhancement by 3' Interferon of the Eighty-Third Annual Meeting of the AACR Fiorella Guadagni, Mario Roselli, Teresa Amato, Maurizio Localization of Rodioiabeled F(ab')2 Fragments of Anti-Intercellular AACR Special Conferences in Cancer Research Cosimelli, Pasquale Peril, Vincenzo Casale, Massimo Carlini, Adhesion Molecule-I Monnelonal Antibodies in Human Colon Car- Future Ann~al Meetings of the AACR Eugenio Santoro, Renato Cavaliere, John W. Greiner. and Jeffrey einoma Ceils Grafted in Node Mice. Masashi Matsoi, Satomichi Recent Deaths Schlom, Yoshimura, Toshihiro NakanishL and Soldano Ferrone. Calendar of Events 1228 Selective Radiation of Hematolymphoid Tissue Delivered by Anti- 1314 Successful Treatment of Human Acute T-Cell Leukemia in SCID 1382 Erratum CD45 Antibody. Dana C. Matthews, Christopher C. Badger, Mice Using the Anti-CD7-deglycosylated Ricin A-Chain Immuno- K. Stromberg et al., 52 341-347, 1992. Darrell R. Fisher, T. Edmund Hui, Cynthia Nourigat, Frederick R. toxin DA7. Burkhard Jansen. Daniel A, Vallera. Waclaw B. Jaszcz, Appelbaum, Paul J. Martin, and Irwin D, Bernstein, Dat Nguyen, and John H. Kersey. 1383 Author Index

March 15, Number 6

EDITORIAL 1451 Chromosome 3p Deletions in Head and Neck Carcinomas: Statistical 1520 Immunoreaetive Human Chorionic Gonadotropin and Its Free fl Ascertainment of Allelic Loss. Farida Latif, Matthew Fivash, G|adys Subunit in Serum and Aseites of Patients with Malignant Tumors. 1385 Progress Report on ~Advances in Brief." Carlo M. Croce. Glenn, Kalman Tory, Mary Lou Orcutt. Krista Hampsch, John Rudolf Hoermann, Alexander L. Gerbes, Gerald Spoettl, Dieter Delisio, Michael Lerman, Janet Cowan. Michael Beckett, and Ralph Jungst, and Klaus Mann. Weichselbaum. 1525 Tumor-promoting Phorbol Ester Down-Regulates the Androgen In- 1386 Inhibition of Tumor-specific Cytotoxic T-Lymphocyte Responses by 1457 Elevated Expression of pp60 ~ in Low Grade Human Bladder duction of Prostate-specific Antigen in a Human Prostatic Adenocar- Trunsforming Growth Factor Bt. Thomas H. Inge, Shelley K. Hoover. Carcinomas. Paul Fanning, Kathleen Bulovas, Kulvinder S. Saini, cinoma Cell Line. P. E. Andrews, C. Y-F. Young, B. T, Montgomery, Brian M, Susskind, Sandra K. Barrett, and Harry D, Bear. John A. Libertino, Adrian D, Joyce. and lan C. Summerhayes. and D. J. Tindall, 1393 Frequent Association of p53 Gene Mutation in Invasive Bladder 1463 Reduced Blood Clearance and Increased Urinary Excretion of N- 1530 Cytostatic and Cytoloxie Effects of Fostriecin on Human Promyelo- Cancer. Kiyohide Fujimoto, Yukishige Yamada, Eigoro Okajima, Nitrosodimethylamine in Paras Monkeys Exposed to Ethanol or cytic HL-60 and Lymphocytic MOLT-4 Leukemic Cells. Michel A. Tadao Kakizoe. Hiroki Sasaki. Takashi Sugimura, and Masaaki Isopropyl Alcohol. Lucy M. Anderson, Raymond Koseniauskas, Hotz. Giacinta Del Bino, Piotr Lassota, Frank Traganos, and Terada. Eric S. Burak. Thomas J. Moskal, Charles T. Gombar, Jure M. Zbigniew Darzynkiewicz. 1399 Selective Events in the Metastatic Process Defined by Analysis of Phillips. Eric B. Sansone, Scott Keimig, Peter N. Magee. JerD M. 1536 A Gene from Human Chromosome Region 3p21 with Reduced the Seqnenlial Dissemination of Snbpopniations of a Moose Mam- Rice. and George W, Harrmgton. Expression in Small Cell Lung Cancer, Ben Carntt, Klaas Kok, Anke mary Tumor, Cheryl J. Aslakson and Fred R. Miller. 1469 Acquired Radioresistance of Hematopoietic Progenitors (Granulo- van den Berg, Jan Osinga, Alison Pilz, Robert M. W. Hofstra. 1406 Phase I Trial and Clinical Pharmacology of EIsamitrucin. Martin N. eyte/Monneyte Colony-forming Units) during Chronic Radiation Leu- Mary B. Davis, Anneke Y, van der Veen, Pamela H, Rabbitts. Rebec. Robert A. Newman, Beverly M. Newman, Robert C. Gaver, kemogenesis. Thomas M. Seed and Li|lian V. Kaspar. Kiran Gulati, and Charles H. C. M. Buys. and Lee P. Schacter. 1542 Induction of Colon Adenocarcinomas in CD Rats and Lung Adenomas 1477 Effect of Tamoxifen on Preneopiastic Cell Proliferation in N-Nitroso- 1411 Steroid and Growth Factor Modulation of Aromatase Activity in in ICR Mice by 6-Nitrochrysene: Comparison of Carcinogenicity and N-methylarea-induced Mammary Carcinogenesis. Michael P. MCF7 and T47D Breast Carcinoma Cell Lines. Carolyn M. Ryde, Aryl Hydrocarbon Hydroxylase Induction in the Target Organs of Osborne. Jeanne F. Ruperlo, Joseph P. Crown. Paul P. Rosen, and Joannr E. Nicholls, and Mitchell Dowsett, Each Species. Katsumi lmaida, Chikako Uneyama, Hiroyuki Nitin T. Telang. Ogasawara, Shuji Hayashi, Kiyoshi Fukuhara. Naoki Miyata, and 1416 Hepsulfam Sensitivily in Human Breast Cancer Cell Lines: The Role 1481 Chromosome Abnormalities in Adult T-Cell Leukemia/Lymphoma: Michihito Takahashi. of Glutathione and Glutathione S-Tronsferase in Resistance. A Karyotype Review Committee Report. Nanao Kamada, Masaharu Deborah K. Armstrong, Gary B, Gordon, John Hilton, Robert T. Sakurai, Kanji Miyamoto. Isao Sanada. Naoki Sadamori, Shirou 1546 A Metastatic Tumor Cell Line Hus Greatly Reduced Levels of a Streeper. O. Michael Colvin, and Nancy E. Davidson. Fukuhara. Syuiti Abe, Yukimasa ShiraishL Tatsuo Abe, Yasuhiko Specific Homotypic Cell Adhesion Molecule Activity. Mark E. Reeves. 1422 Tumor Invasion-inhibiting Factor 2: Primary Slrneture and Inhibitory Kaneko, and Masanori Shimoyama. Effecl on Invasion in Vitro and Pulmonary Metastasis of Tumor 1553 Tumor Types Derived from Epithelial and Myoepithelial Cell Lines 1494 Loss of Heterozygosity at Chromosome Iq22 in Basal Cell Carcino- Cells. Atsushi lsoai, Yuko Giga-Hama, Kiyoko Shinkai, Mutsuko of R3230AC Rat Mammary Carcinoma. Anna Sapino, Mauro mas and Exclusion of the Basal Cell Nevus Syndrome Gene from Mukai, Hitoshi Akedo, and Hiromichi Kumagai. Papotti, Brunelia Sanfilippo, Patrizia Gugliotta, and Giannt This Site. John W, Bare, Roger V. Lebo, and Ervin H. Epstein, Jr. Bussolati. 1427 p53 Malarious in Human Malignant Gliomas: Comparison of Loss of Heterozygosity with Mutation Frequency, Roger H. Frankel. 1499 Determinants of Polycyclic Aromatic Hydrocarbon-DNA Adducts 1561 Expression of High-Affinity Laminin Receptor mRNA Correlates William Bayona, Maxim Koslow, and Elizabeth W. Newcomb. in Human Placenta. David K. Manchester. Elise D. Bowman, with Cell Proliferation Rather than Invasion in Human Papilloma- Natalie B. Parker, Neff E, Caporaso, and Ainsley Weston. virus-ussociated Cervical Neoplasms. Lisa M. Demeter, Mark H. 1434 Mechanisms of Natural Resistance In Antifoiales in Human Soft Stoler. Mark E. Sobel, Thomas R, Broker, and Louise T. Chow. Tissue Sarcomas. Wei-Wei Li, James T. Lin, William P. Tong, 1504 Different Pattern of Chromosomal Allele Loss in Multiple Hepar Tanya M. Trippett, Murray F. Brennan, and Joseph R. Bertino. cellular Carcinomas as Evidence of Their Multifucal Origin. Hitoshi 1568 Molecular Characterization of Areas with Low Grade Tumor or Tsuda, Tatsuya Oda, Michiie Sakamoto. and Sctsuo Hirohashi. Satellitosis in Human Malignant Astrocytomas. Sieger Leenstra, Dirk 1439 A Model for Initiated Mouse Skin: Suppression of Papilloma but not Troost, Andries Westerveld, D. Andries Bosch, and Theo J. M. Carcinoma Formation by Normal Epidermal Cells in Grafts on 1510 Detection of Polyeyclic Aromatic Hydrocarbon-DNA Adducts in Hulsebos. Athymic Nude Mice. James E. Striekland, Masato Ueda, Henry White Blood Cells from Coke Oven Workers: Correlation with Job Hennings, and Stuart H. Yuspa. Categories. Steinar Ovrebo, Aage Haugen, David H. Phillips, and 1573 Nephrocalcin: Biosynthesis by Human Renal Carcinoma Cells in Alan Hewer. Vitro and in Viro. Y. Nakagawa, D, Sirivongs, M B. Novy, 1445 Differentiation and Retrudifferentialian of Human Myeloid Leuke- Michael F. Netzer, Eli Michaels, N. J. Vogelzang. and Fr L. Cue. mia Cells Is Associated with Reversible Induction of Cell Cycle- 1515 DNA Damage and Cytotoxicity in LI210 Cells by" Elliptieine and a regulatory Genes. Ralf Hass, Hisato Gunji, Rakesh Datta, Svrender Structural Analogue, N-2-(Diethylaminoethyl)-9-hydroxy-ellipticio- 1580 Influence of Chromatin Structure on the Induction of DNA Double Kharbanda, Andreas Hartmann, Ralph Weichselbaum, and Donald ium Chloride. Zora Djuric. Carleen K. Everett, and Frederick A. Strand Breaks by Ionizing Radiation. Michael C. Elia and Kufe. Valenote. Matthews O, Bradley.

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1587 Accumulation of nOB in the Central Degenerative Areas of Human 1615 Induction of Thingmmine-resistant Mutations in Human Urnepithe- 1635 p53 Mutations Cluster at Codon 249 in Hepatitis B Virus-positive Glinma and Colon Carcinoma Spheroids after Sul[hydryl Boron Ilal Cells by 4-Aminobiphenyl and Its N-Hydroxy Derivatives. Hepntocellular Carcinomas from China. Kathleen A. Scorsone, Yi- Hydride Administration. Orn-Anong Pettersson, J6rgen Carlsson, Elizabeth A. Bookland, Catherine A. Reznikoff, Mary Lindstrom, Zhong Zhou, Janet S. Butel, and Betty L. Single. and Erik Grusell. and Santhanam Swaminathan. 1639 Conjugation of Bonze(a)pyrenc 7,8-Dihydrodiel-9,10-epoxidein in- 1622 Overexpression and Mutation of p$3 in Endometrinl Corr fant Swiss-Webster Mice. Gloria Y. Kwei, Jan Zaleski, Susan E, 1592 Measurements of Blood Flow and Exchanging Water Space in Breast Matthew F. Kohler, Andrew Bet'chuck, Andrew M. Davidoff, Irwin, Ronald G. Thurman, and Frederick C. Kauffman. Peter A. Humphrey. Richard K. Dodge, J. Dark lglehart, John T. Tumors Using Pnaitron Emission Tomo8raphy: A Rapid and Non- 1643 The Human Prohibitin Gone Located on Chromosome 17q21 Is involve Dynamic Method. Charles B. J. H. Wilson, Adriaan A. Soper, Daniel L, Clarke-Pearson, Robert C. Bast, Jr., and Jeffrey R. Marks. Mutuled in Sporadic Breast Cancer. Takaaki Sato, Hiroko Santo, Jeff Lammensma, Christopher G. McKenzie, Karol Sikora, and Terry Swensen, Arnold Olifant, Carla Wood, David Danner, Takashi Jones. Sakamoto, Kenichi Takita, Fujio Kasumi, Yoshio Miki, Mark Skolnick, and Yusuke Nakamura. 1598 Serum Prostate Specific Antigen Levels in Mice Bearing Human Prostate LNCaP Tumors Are Determined by Tumor Volume and ADVANCES IN BRIEF Endocrine and Growth Factors. Martin E. Gleave, Jer-Tsong Hsieh, 1647 Announcements Hal-Chin Wu, Andrew C. yon Eschenbach, and Leland W. K. Chung. Eighty-Third Annual Meeting of the AACR 1628 Inhibition of Chemical Carcinogenesis io Viro by Azatyrosinc. AACR Special Conferences in Cancer Research Mitsuo Izawa, Shozo Takayama, Nobuko Shindo-Okada, Satoro Future Annual Meetings of the AACR Don, Minoro Kimura, Motoya Katsuki, and Susumu Nishimura. 1606 Tumorillonk Transformation and Neoplastic Progression of Human Calendar of Events Uroepithelinl Cells after Expoonro io Vitro to 4-Aminobiphenyl or 1631 Lo~ of the 3p13-*p21.2 in Tumorigenic Reversion of a Hybr 1649 Erratum its Metubolites. Elizabeth A. Bookland, Santhanam Swaminathan, between Isngencic Nontumorigenic and Tumorigonk Human Uro- H. M. Schuller et al., 50:1645-1649, 1990. Ryoichi Oyasu, Kennedy W. Gilchrist, Mary Lindstrom, and epithelial Cells. Aloysius J. Klingelhutz, Shi-Qi Wu, Jinwen Huang, Catherine A. geznikoff. and Catherine A. Reznikoff. 1650 Author Index

April 1, Number 7

PERSPECTIVES IN CANCER RESEARCH 1757 Metabolism of 4-(Methylnitrosomino)-1-(3-pyHdyl)-l-butuoonein 1868 Roles of Human Liver Cytochrome P4502C and 3A Enzymes in the Human Lung and Liver Microsomes and Cytnchromes P-450 Ex- 3-Hydroxylation of Bonzo(a)pyrene. Chul-Ho Yun, Tsotomu 1651 Natural History of Intraepithellal Neoplasia in Humans with Impli- pressed in Hepatoma Cells. Theresa J. Smith, Zuyu Guo, Frank J, Shimada. and F. Peter Guengerich. cations for Cancer Chemoprevention Strategy. Charles W, Boone. Gonzalez, F. Peter Guengerich, Gary D. Stoner. and Chung S. Yang. Gary J. Kelloff, and Vernon E. Steele. 1875 Elevation of dB-Galactosyltransferuse Activity for Parogloboside 1764 Retention of Cellular Radiation Sensitivity in Cell and Xeoograft Synthesis in Sera of Patients with Cancer. Shigeru Nishiwaki, Takao Lines Established from Human Melanoma Surgical Specimens. Taki, Nobuko Handa, Nobu Hattori, Kimiya Takeshita, Mitsuo Einar K. Rofstad. Endo, and Shizuo Handa. 1660 Brequinor Potentiates 5-Fleoroaracil Antitumor Activity in a Marine Model Colon 38 Tumor by Tissue-specific Modulation of Uridine 1770 Roleof Aldehyde Dehydrogeonsein the Protection of Hematopoietic 1881 AllelicLosses at Chromosome 17p in Human Renal Cell Carcinoma Nuclentide Pools. Giuseppr Pizzorno, Rosemary A. Wiegand, Progenitor Cells from 4-Hydroperoxycyclophosphamideby Interleu- Are Inversely Related to Allelic Losses at Chromosome 3p. Osamu Sarah K. Lentz. and Robert E. Handschumacher. kin IB and Tumor Necrosis Factor. J. Moreb, J. R. Zucali. Y. Zhang, Ogawa. Tomonori Habuchi, Yoshiyuki Kakehi. Masahiro Koshiba, M. O. Colvin. and M. A. Gross. Taketoshi Sugiyama, and Osamu Yoshida. 1666 Multidrog Sensitivity Phenotypo of Human Lung Cancer Cells As- snclated with Topoisomerase Ii Expression. Giuseppe Giaccone, 1775 Sinlyltransferase Activity and Hepatic Tumor Growth in a Nude 1886 Biochemical Characterization of Resistance to Mituxantrone and Adi F. Gazdar, Hans Beck, Franco Zunino, and Giovanni Mouse Model of Colorectal Cancer Metastases. Brian E. Harvey, Adriamycin in Coco-2 Human Colon AdenocarcinomaCells: A Pos- Capranico, Carol Ann Toth. Hans E. Wagner, Glenn D. Steele, Jr.. and Peter sible Role for Glntathione S-Traosferases. Wilbert H. M. Peters and Thomas. Hennie M. J. Roelofs. 1675 Careinogenicity of Uracil a Nongenotoxic Chemical in Rats and Mice and Its Rationale. Shoji Fukushima, Hikaru Tanaka, Emiko 1780 Loss of Heterozygosity for Chromosomes I or I d Defines Subsets of 1891 Inhibitors of Polyamine Biosynthesis Block Tumor Necrosis Factor- Asakawa, Masataka Kagawa. Atsoshi Yamamolo, and Tomoyuki Advanced Nenroblastomas. Chin-to Fong, Peter S. White. Karen induced Activation of macrophoges. Leszek Kaczmarek. Bozena Shirai. Peterson, Carmen Sapienza. Webster K. Cavenee. Scott E. Kern. Kaminska, Luigi Messina, Giuseppina Spampinato, Antonio Bert Vogelstein. Alan B. Cantor. A. Thomas Look. and Garrett M. Arcidiacono, Lucia Malaguarnera, and Angelo Messina. 1681 Production and Cheraclerizatinn of n MuHne/HunumChimeric Anti- Brodeur. Idiotype Anlibedy That Mimics Ganglinside. Alice Hastings, 1895 Mitochondrial Defects in cls-Diammiuedichlornplatinum(ll)- Sherie L. Morrison. Shinji Kanda, Romaine E. Saxton, and 1786 Bombesinand Glucocorticoids Stimulate Human Breast Cancer Cells resistant Human Ovarian Carcinoma Cells. Paul A. Andrews and Reiko F. Irie. to Produce Endothelin~ a Paraerine Mitngen for Breast Stromal Cells. Kathleen D. Albright. Michael P. Schrey, Kirti V. Panel, and Nikolaos Tezapsidis. 1687 Radinsensitization by FinorodeaxynHdine: Effects of Thymidylate 1902 Loss of cis-Diamminedichloroplalionm(ll) Resistance in Human 1791 Association of Cyst Type with Risk Factors for Breast Cancer and Synthese Inhibition and Ceil Synchronization. Elizabeth M. Miller Ovarian Carcinoma Cells Selected for Rhodamine 123 Resistance. Relapse Rate in Women with Gross Cystic Disease of the Breast. and T. J. Kinsella. Karen Zinkewich-P~otti and Paul A. Andrews. Carlo Naldoni, Massimo Costantini. Luigi Dogliotti, Paolo Bruzzi, 1695 p53 Mutations in Human Lung Tumors. Carl W. Miller. Kenneth Lauro Bucchi. Gianfranco Buzzi. Mirella Torla. and Alberto Angola. 1907 Acquisition of a Growth-inhibitory Response to Phorbol Ester In- Simon, Abdulkarim Aslo, Klaas Kok. Jan Yokola, Charles H. C. M. volves DNA Damage. Yi Sun, Yves Pommier, and Nancy H. Buys, Masaaki Terada, and H. Phillip Koeffier. 1796 Stable Expression of Human Cytochrome P45011E I in Mammullan Cells: Metabolic Activntionof Nitrosodimethylamineand Formation Colbarn. of Addocts with Cellular DNA. Kazuhiro Nouso, Snorri S. 1699 Involvement of Xanthine Oxidase in Oxidative Stress and Iron Re- 1916 Radiolabeled Antibody Targeting of the HER-2/neu Oncoprotein. Thorgeirsson. and Narayana Battula. lease during Hyporthecmic Rat Liver Perfusion. Robert H. Powers, Kenneth De Santos. Dennis Slamon, Susan K. Anderson, Michael Anna Stadnicka, John H. Kalbfieish. and Joseph L. Skibba, 1801 Relevanceof EnvironmentulAIkylating Agents to Repair Protein 06- Shepard, Brian Fondly, Daniel Maneval, and Oliver Press. 1704 Differential Effects of Estrogen and Antiestrogea on Transforming Alkyignanine-DNA Alkyltraosferase: Determination of Individual 1924 Developmentof Mammary Preneoplasias in Viva from Mouse Mam- and Collective Repair Capacities of O%Methylguanine. F. Oesch and Growth Factor Gone Expression in Eodometrlal Adenocorcioomu mary Epithelial Cell Lines in Vitro. Frances S. KJttrelL Carol J. S. Klein. Cells. Yuewen Gong, Guslavo Ballejo. Leigh C. Murphy, and Oborn. and Daniel Medina. Liam J. Murphy. 1804 lrradintion-indnced Expression of O6-Methyigonnine-DNA Methyl- 1933 Formation of PCI2 Tumors after Transplantation into Rat Brains: 1710 Establishment and ChecacteHzation of an io Vitro Mndel of Acquired Iransfezase in Mammalian Cells. C-U Chan, Zining Wu. Alan Eastman. and Edward Bresnick. Dependence of Time Course on Host Age. James D. Hatton, Alex N. Resistance to Cisplattn in a Human Tentacular Nonsomioomatoos Lechtman, and Hoi Sang U, Germ Cell Line. Lloyd R. Kelland, Prakash Mistry. George Abel, 1810 Reversal of Vinea Alkaloid Resistance by Anti-P-Glycoprotein Frank Freidlos, Swee Y. Loh, John J. Roberts, and Kennelh R. Monoclonal Antibody HYB-241 in a Human Tumor Xeangraft. 1938 Migratury Behavior of PCI 2 Cells Transplanted into Neonatal Rat Harrap. Lana S. Rittmann-Grauer, Milicent A. Yong, Vikki Sanders, and Brain. James D. Hatton, Brent C, Jackson, Patricia Y. Kelley. and Daniel G, Mackensen. Hoi Sang U. 1717 Determination of Plasma Urokinase-typo Plosminogen Activator An- tigen in Patients with Primary Liver Cancer: Characterization as 1817 Inhibition of p34'~z Kinase Activation, p34'.2 Tyrosine Dephospho- 1943 Inhibitlon of N-Nitrosodiethylamine- and 4-(Methylnitrosamino)-I- Tumor-assoclatndAntigen and Comparison with a,-Fetoproleio. Kurt rylntion, and Mitotic Progression in Chinese Hamster Ovary Cells (3-pyridyl)-l-butanone-inducedTumorigenesis in A/J Mice by Green Huber, Johannes C. Kirchheimer, Dorolhca Ermler, Cameron Bell, Exposed to Etoposide. Richard B. Lock. Tea and Black Tea. Zhi Yuan Wang, Jun-Yan Hong, Mou-Tuan and Bernd R. Binder. Huang, Kenneth R. Reuhl, Allan H. Conney, and Chung S. Yang. 1823 The Involvementof Active DNA Synthesis in Camptothecin-indoced 1721 BonzoquioonoidAnsomycins Possess Selective Tumorieidal Activity G2 Arrest: Altered Regulation of p34'~Z/Cyclin B. Yeou-Ping Tsao, 1948 2s2CfRelative Biological Effectiveness and Iuherituhle Effect of Fis. Unrelated 1o arc Kidnap Inhibition. Luke WhiteselL Stuart D. Shifrin, Peter D'Arpa, and Leroy F. Liu. sion Neutrons in Mouse Liver Tumorigenesis. Tadateru Takahashi, Gisela Schwab, and L. M, Neckers. 1830 Suramin Inhibits the Growth of Human Rhnbdomyosarcomn by Hiromitsu Watanabe, Kiyohiko Dohi, and Akihiro ltd. Interrupting the Iosulin-like Growth Factor II Autocrine Growth 1729 Enhancement of 5-Flooro-2'-denxyuridinc Anlineoplastic Activity by Loop. Caterina P. Minniti, Mario Maggi. and Lee J. Helman. 1954 Tissue-spociflcExpression of a Human Polymorphic Epithelial Mu, S-ISenzyloxybsnzyloxybenzylacyclouridineIn a Human Colon Carci- can (MUC1) in Transgenic Mice. Nigel Peat, Sandra J. Gendler, ooma Cell Line. Edward Chu, Ming Y. Chu, James W. Darnowski. 1836 Induction of Mutation of a Synthetic c-Ha-ros Gone Containing EI-Nasir Lalani, Trevor Duhig, and Joyce Taylor-Papadimitriou. Zhi H. Chen. Ban C. Pan, and Shah H. Chu. Hypoxanthine. Hiroyuki Kamiya. Hiroyuki Miura, Hisayo Kato. Susumu Nishimura, and Eiko Ohtsuka. 1961 Intratumoral and Whole-Body Distributions of C110 Anti-Carci- 1737 Fate of Clonal Lineages during Nenplasla and Metastasis Studied noembryonic Antigen Radioimmuuutoxin after Intraperitoneul and with an Incorporated Gonetie Marker. Bruce F. Moffett, Dilair 1840 Differential Effects of Polyamine Homolognes on the Prevention of Intravenous Injection: A Quantitative Autoradiographic Study. Baban, Lore Baoo and David Tarin. m.-a-Diflnoromethylornithine-medlatedInhibition of Malignant Cell Tsunao Ito, Thomas W, Griffin, Jeffrey A. Collins, and A. Bertrand Growth and Normal Immune Response. Ajay B. Singh, T. J. Thomas, Brill. 1744 Eicosaooid Production by the Human Gostric Cancer Cell Line AGS Thresia Thomas, Manjeet Singh. and Richard A. Mann. and Its Relation to Cell Growth. Shuya Shimakura and C. Richard 1968 Expression of the Retinoblastoma Gene Product in Bladder Carci- Boland. 1848 Topoisomerose I Alteration in u Cumptothecin-resistant Cell Line Derived from Chinese Hamster DC3F Cells in Culture. Akihiko noma Cells Associates with a Low Frequency of Tumor Formation. David W, Goodrich, Yumay Chen. Peter Scully. and Wen-Hwa Lee. 1750 Tempol, a Stable Free Radical, Is a Novel Murinc Radiation Protec- Tanizawa and Yves Pommier, tor'. Stephen M, Hahn. Zelig Tochner, C. Murali Krishna, Joseph 1855 NovelMechonlsm(s) of Resistunce tu 5-Fluorouracil in Human Colon 1974 Expression of p53 and 17p Allelic Loss in Colorectal Carcinoma. Glass, Lynn Wilson, Amram Samuni, Merle Sprague, David Venzon, Cancer (HCr-8) Sublines following Exposure to Two Different Clin- Julie Cunningham, John A. Lust, Daniel J. $chaid, Gary D. Bren, Eli Glalstein, James B. Mitchell, and Angelo Russo. ically Relevant Dose Schedules. Carlo Aschele, Alberto Sobrero. Herschel A. Carpenter, Elizabeth Rizza. John S. Kovach, and Mary A. Faderan, and Joseph R. Bertino. Stephen N. Thibodeau. 1754 Iohibition of Bonzo~aipycene-indncedMouse Forostomoch Neaplasia by a Principal Flavor Component of Japancse-slyle Fermented Soy 1865 Therapontk Aetivity of a Thinather-Lipid Conjugate of I-B-wAra- 1981 Immanohistochemical Localization of Cell Adhesion Molecule Epi- Sauce. Ayumu Naaahara, Hanna Benjamin. Jayne Storkson, Jennifer binofuranosylcytualne in Human Colorectal Cancer Xeoografts. thelial Cadherin in Human Arachnoid Villi and Meningiomas. Yasuo Krewson. Kuan Sheng, Wen Liu. and Michael W. Pariza. Richard Herrmann and Wolfgaog E. Berdel. Tohma, Tetsumori Yamashima. and Junkoh Yamashita.

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ADVANCES IN BRIEF 2000 Altered Steady-State Levels of the Messenger RNAs for c-myc and MEETING REPORT p53 in LI210 Cell Lines Resistant to Deoxyadenosine. Joseph G. 1988 Pheaylueetate: A Novel Nontoxic Inducer of Tumor Cell Differentia- Cory, Ann H. Cory, Sheree D. Long, Gay L, Carter, and Cheryl E. 2012 The Beijing Blood Cell Growth Factors Symposium--Blood Cell tion. Dvorit Samid, SonsolesShack, and Lin Ti Sherman. Johnson. Growth Factors: Their Present and Future Use in Hematology and Oncology. Nicos A. Nicola and Martin J. Murphy, Jr. 1993 Interstitial Hypertension in Head and Neck Tumors in Patients: 2004 Expression of Fibroblast Growth Factor Receptors in Human Leu- Correlation with Tumor Size. Ralph Gutmann,Michael Leunig, Jens kemia Cells. Elina Armstrong,Satu Vainikka, Juha Partanen, Janna 2014 Announcements Feyh, Alwin E. Goetz, Konrad Messmer, Ernst Kastenbauer, and Korhonen, and Riitta Alitalo. Eighty-Third Annual Meeting of the AACR Rakesh K. Jain. AACR Special Conferences in Cancer Research 2008 Efficient Repair of O%Ethylguanine, but not O~-Ethylthymine or Future Annual Meetings of the AACR 1996 Polymorphir Sites within the MCC and APC Loci Reveal Very O2-E~ylthyn~, Is Dependent upon O'-Alkylgwmlae-DNAAlkyl- Recent Deaths Frequent Loss of Heterozygosity in Haman Small Cell Lung Cancer. transferase and Nucleotide Excision Repair Activities in Human Calendar of Events Domenico D'Amico, David P. Carbone, Bruce E. Johnson, Cells. S. Maynard Bronslein, Thomas R. Skopek, and James A. Stephen L Meltzer, and John D. Minna. Swenberg, 2017 Author Index

April 1, Number 7, Supplement

Scientific Planning Committee and Faculty Listings ...... 2022s Foreword Alex Malaspina ...... 2023s

Keynote Address

The Lessons of Life Sir Richard Doll ...... 2024s

Session I: Fats and Energy

Role of lntervention Trials in Research on Nutrition and Cancer Maureen M. Henderson ...... 2030s Dietary Energy and Fat Effects on Tumor Promotion Diane F. Birt, Edward S. Kris, Myeon Choe, and Jill C. Pelling ...... 2035s Relationship between Dietao' Fat and Experimental Mammary Tumorigenesis: A Review and Critique Clifford W, Welsch ...... 2040s Differential Effects of Dietary Linoleic Acid on Mouse Skin-Tumor Promotion and Mammary Carcinogenesis Susan M. Fischer, Julius Leyton, Marilyn L Lee, Mary Locniskar, Martha A. Belury, Regina E. Maldve, Thomas J. Slaga, and David H. Bechtel ...... 2049s Dietary Fiber-mediated Mechanisms in Carcinogenesis David M. Kluffeld ...... 2055s

Session i!: Micronutrients and Microconstituents

Does 13-Carotene Explain Why Reduced Cancer Risk Is Associated with Vegetable and Fruit Intake? Regina G. Zingier, Amy F. Subar, Neal E. Craft, Giske Ursin, Blossom H. Patterson, and Barry I. Graubard ...... 2060s Calcium, Vitamin D, and Colon Cancer Harold L. Newmark and Martin kipkin ...... 2067s Methyl Groups in Carcinogenesis: Effects on DN,4 Methylation and Gene Expression Elsie Wainfan and Lionel A. Poirier ...... 2071s Orotic Acid. Nucleotide-Pool Imbalance. and Liver-Tumor Promotion: A Possible Mechanism Jar the Mitoinhibitoo" Effects of Orotic Acid in Isolated Rat Hepatoo'tes Sharmila Manjeshwar, Aisha Sheikh, Giuseppina Pichiri-Coni, Pierpaolo Coni, Prema M. Rao, Srinivasan Rajalakshmi. Peter Pediaditakis, George Michalopoulos, and Dittakavi S. R. Sarma ...... 2078s Nitrogen-stimulated Orotic Acid Synthesis and Nucleotide Imbalance Willard J. Visek ...... 2082s Inhibition of Carcinogenesis by Minor Dietao" Constituents Lee W. Wattenberg .... : ...... 2085s

Session I!1: Diet-associated Carcinogens and Mutagens

Food-derived Mutagens and Carcinogens Keiji Wakabayashi, Minako Nagao. Hiroyasu Esumi, and Takashi Sugimura ...... 2092s Metabolic Activation and Genotoxicity of Heteroo'clic Ao'lamines Eliza',,:th G. Snyderwine, Herman A. J. Schut, Richard H Adamson, Unnur P. Thorgeirsson, and Snorri S. Thorgeirsson ...... 2099s Chemical Analysis. Prevention, and Low-Level Dosimeto' qf Heteroo'clic Amines Jrom Cooked Food James S. Felton, Mark G. Knize, Michelin Roper, Esther Fultz, Nancy H. Shun, and Kenneth W. Turteltaub ...... 2103s Metabolism of Food-derived Heteroo'clic Amines in Human and Rabbit Tissues by P4503A Proteins in the Presence of Flavonoids Ross A. McKinnon, Wendy M. Burgess, Pauline de la M. Hall. Zaiminuddin Abdul-Aziz, and Michael E. McManus ...... 2108s Aflatoxins as Risk Factors for Hepatocelhdar Carcinoma in Humans Gerald N. Wogan ...... 2114s

Session IV: Mechanisms and Risk Assessment

Alcohol and Cancer William J. Blot ...... 2119s Panel Discussion Allan H. Conney (Session Chairperson), Richard H. Adamson, Ronald W. Hart, Robert J. Scheuplein, Arpad Somogyi, and Takashi Sugimura ...... 2124s

A uthor Index ...... 2126s

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April 15, Number 8

PERSPECTIVES IN CANCER RESEARCH 2216 Alterations in Protein Kinase C in 1,2-Dimethylhydrszine Induced 2318 Suppression of Cellular Aggregation by High Levels of Episialin. Colonic Carcinogenesis. Patricia A. Craven and Frederick R. Marjolijn J. L. Ligtenberg, Femkc Buijs, Hans L, Vos, and John 2127 Evolving Concepts in the Systemic Adjuvant Treatment of Breast DeRubertis. Hilkens. Cancer. Gianni Bonadonna. 2222 Adrenal Carcinoma Tumor Progression and Penultimate Cell Sur- 2325 Prognostic Influence of HSP-27 Expression in Malignant Fibrous face Oligosaccharides. Man-shiow Jiang, Antonino Passaniti. Histineytoma: A Clinicopathologieal and Immonohistucbemical Margaret B. Penno, and Gerald W. Hart, Study. Bernard T6tu, Bernard Lacasse, Henri-Louis Bouchard, R~al Lagac~, Jacques Huot, and Jacques Landry. 2138 Clinkal Pharmacology of Oral All-trams Retinok Acid in Patients 2228 Quantitution of Folk Acid Enhancement of Antlfointe Synergism. 2329 Specifidty and Affinity of Monoclonal Antibodies against Carcinoem- with Acute Promyelocytic Leukemia. Josephia R. F. Muindi, Stanley Yvcttr Gaumont, Roy L, Kisliuk, John C. Parsons, and William R. byronic Antigen. Marius Nap. Marie-Louise Hammarstr6m, Ole R. Frankel. Christine Husehon, Francis DeGrazia, William A. Greco. Garland, Charles W. Young, and Raymond P. Warreii, Jr. Bormer, Stun Hammarstrom, Christoph Wagoner, Stefan Handt, 2236 Expression and Regulation of Retianic Acid Receptors in Human Magali Schrcyer, Jean-Pierre Mach, Franz Buchegger, Sabine yon 2143 in Vivo Administratlon of Bryostatin l,a Protein Kinase C Activalor, Breast Cancer Cells. Shaun D. Roman, Christine L. Clarke, KJcist. Fritz Grunert, Patrick Seguin, Abraham Fuks. Ruth Holm, Decreases Murine Resistance to Salmonello typhimurium. Andrew Rosemary E. Hall, tan E. Alexander, and Robert L. Sutherland. and Rolf Lamerz. S. Krat~, Victor Adler, Patti Hall, George R. Pettit, William H. Benjamin. Jr., and David E. Briles. 2243 Frcqnency and Diversity of p53 Mutations in Childhood Rhabdo- 2148 Biochemical pad Biological Studies on 2-Desamino-2-methylaminop- mynsarcoma. Carolyn A. Felix, Cymhia Chavcz Kappel. Tetsuya turin, an Anlifoiate tbe Polyglotumatus of Which Are More Potent Mitsudomi, Marion M. Nau, Maria Tsokos. Gary D, Crouch, Than the Monnglutamatu against Three Key Enzymes of Folate Perry D. Nisen, Naomi J. Winick, and Lee J. Hr ADVANCES IN BRIEF Metabolism. A. Rosowsky, J. Galivan. G, P, Beardsley, H. Bader. B. M. O'Connor. O. Russello+ B. A. Moroson+ M. T. DeYarman. 2248 Human Ovarian Epithelial Cancer Cells Cultured in Vitro Express 2340 Wild-type but not Mutant p53 Suppresses the Growth of Human S. S. Kerwar, and J. H. Freisheim. Both Inturleukin la and B Genes. B-Y. Li, D. Mohanraj, M. C. Lung Cancer Cells Bearing Multiple Genetic Lesions. Takashi OIsom M. Moradi, L. Twiggs, L. F. Carson, and S. Ramakrishnan. Takahashi+ David Carbone, Toshitada Takahashi. Marion M. Nau, 2156 Phosphorylatlon of Topoisomerese II by Casein IGonse II and Protein Toyoaki Hida, Ilona Linnoila. Ryuzo Ueda, and John D. Minna. Kionse C: Effects of Enzyme-mediated DNA Cleavoge/Religatlon 2253 Immnelalizatlon of Carcinogen-treated Syrian Hamster Embryo and Sensitivity tu the Antineoplastk Drugs Etoposide and 4"-(9- Cells Occurs Indirectly via an Induced Process. Bart L. M. C. Bols, 2344 Differences in Breast Cancer Risk Factors to neu (c-erbB-2) Protein Acridinyiamino)methane-salfon-m-anisidide. Russell F. DeVore, Jolanda M. Naaklgeboren. Paul H. M. Lohman, and Johannes Overexpresslon of the Breast Tumor. Honri~tte F. Treurniet. Anita H. Corbett, and Nell Osberoff. W. I. M. Simons. Matti A. Rookus, Hans L. Pelerse, Augustinus A. M. Hart, and Flora E. van Leeuwen. 2162 Effect of Preirradiatlon of Transphmtation Site on Grnwth Charac- 2257 Time Dependence of the Selective Modulation of Cispiatin-induced teristics and Hypoxic Fractions in Human Colon Tumor Xeoografts. Nephrotuxicity by WR2721 in the Mouse. Marco Treskes+ Epic 2346 Induction of Cytotuxicity by Photuexcited TiP2 Particlos. Ruxiong John T. Leith, Gia Padficld, Lynn Quaranto. and Seth Michelson. Boven. UIbe Holwerda+ Herbert M. Pinedo, and Wire J. F. van der Cai, Yoshinobu Kubota, Taro Shuin, Hideki Sakai, Kazuhito Vijgh. Hashimoto, and Akira Fujishima. 2167 Acute Effects of Tumor Necrosis Factor a or Lymphotoxin on Global 2349 Cancer Cell Motility-inhibitory Protein in the Donning Adenocarci- Blood Flow, Laser Doppler Flux, and Bioonergntk Status of Subcu- 2261 Measurement of Gastrin and Transforming Growth Factor a Mes- noma Model. James L. Moh]er, Elaine N. Broskic, Dipak J. Ranparia, taneous Rodent Tumors. M. Kluge, B. Elger. T. Engel, C. Schaefer, seoger RNA Levels in Colonic Carcinoma Cell Lines by Quantitative Yousuf Sharief, William B, Coleman. and Gary J. Smith, J. Seega, and P, Vaupel. Polymerase Chain Reaction. Graham S. Baldwin and Qun-Xing 2174 DNA Fingerprinting Survey of Various Human Tumors and Their Zhang, 2353 Inhibition of Tumor Cell Invasion by a Highly Conserved Peptlde Metastases. Yasuhiro Matsomura and David Tarin. Sequence from the Matrix Metniloproteinase Enzyme Prosegment. 2268 Effect of P-Glycoprotein Expression on the Accumulation and Cy- A. Melchiori. A. Albini. J. M. Ray, and W. G. Stetler-Stevenson. 2180 Syneegistk Cytotoxicity with 2 '-Deoxy-5-azacytidine ond Topot ecan totoxicity of Topoleean (SK&F 104864), a New Camptothecin Ana- in Vitro and in Vivo. Haruyuki Anzni, Philip Frost. and James L, Ingne. Carolyn B, Hendricks, Eric K, Rowinsky. Louise B. Grochow. Abbruzzesc. Ross C. Donehower, and Scott H. Kaufmann.

2186 Increased Messenger RNA Levels of the Antagonist Thyroid Hor- 2279 Cancer Induction in Mice by Feeding the Raw False Morel Mush- mone Receptor erbA-a2 and Decreased Levels of erbA-al and room Gyromitra escnleata. Bela Toth, Kashinath Patil. Hcikki MEETING REPORTS erbA-Bl Receptor Messenger RNAs in Neoplastic Rodent Cells. Pyysalo, Carol Stessman. and Peter Gannett, Catherine K. L. Too and Duane L. Guernsey. 2357 Working Group on Mechanisms of Carcinogenesis and the Evalua- 2285 Cytugnnelic Analysis of 124 Prospectively Ascertained Male Germ 2191 Rapid High-Affinity Transport of a Chemotherapeutic Amino Acid tion of Carcinogenic Risks. Harri Vainio, Elisabeth Heseltine. Cell Tumors. Eduardo Rodriguez. Susan Mathew. Victor Reuter, across the Blood-Brain Barrier. Yoshiaki Takada, David T. Vistica, Douglas McGregor. Lorenzo Tomatis, and Julian Wilbourne. David H. Ilson, George J. BOsl, and R. S. K, Chaganti. Nigel H. Greig, David Purdon, Stanley 1. Rapoport, and Quentin R, 2362 Eleventh Annual Sapporo Cancer Seminar--Connecting the Dots: Smith. 2292 First Establishment of a Human Monnelonal Antibody Directed to Assembling the Pathways That Control Cell Division. Ed Harlow. 2197 SynerlD, of lnterleukin 3 and Tumor Necrosis Factor a in Stimulating Sulfated Glycosphingolipids SM*,-c.t and S,~, from a Patient with Clonal Growth of Acute Myelogenous Leukemia Blasts Is the Result Lung Cancer. Masayuki Miyake. Toshihiko Taki. Reiji Kannagi. and of Induction of Secondary Hematopoietk Cytokines by Tumor Ne- Shigeki Hitomi. crosis Factor a. Marion A. Brach, Hans-J0rgen Gruss, Yoshinobu 2298 Suppression ofTumur Promoter-indoced Oxidative Events and DNA Asano, Sven de Vos, Wolf-Dieter Ludwig, Roland Mertelsmann, and Damage in Vivo by Sarcophytul A: A Possible Mechanism of Anti- 2367 Announcements Friedhelm Herrmann. promotion. Huachen Wen and Krystyna Frenkel. Eighty-Third Annual Meeting of the AACR AACR Special Conferences in Cancer Research 2202 Up-regulated Biosynthesis and Expression of Endothelial Cell Vitro- 2304 Incidence and Distribution of Experimental Metastases in Mutant Future Annual Meetings of the AACR nectin Receptor Enhances Cancer Cell Adhesion. Robert M, Lafrenie, Mice with Defective Organ Micrnenvironments (Geootypes Recent Deaths Thomas J. Podor. Michael R. Buchanan, and F. William On'. SI/SI ~ and W/W'). Francisco Arguello, Richard W. Furlanetto. Calendar of Events Raymond B Baggs, Brian T. Graves, Shari E. Harwell. Harvey J. 2209 Associated Effects of Bromocriptine on Neoplastic Progression of Cohen, and Christopher N. Frantz. 2369 Errata Mouse Mammary Pronenpiastk Hyperplastk Alveolar Nodule Line Z. Husain et al., 5f: 4964-4970. 1991. C4 and on Hyparplastic Alveolar Nodule-infiltrnting and Splenic 2310 Second Generation Anti-MUCI Peptide Monurlonal Antibodies. S. J. Gartc. 52. 1047-1050, 1992. Lymphocyte Function. S. Jane Tsai, David A. Loeffier, and Pci-xiang Xing, Julia Prenzoska, Kaylcne Quelch, and tan F. C. Gloria H, Heppner. McKenzie. 2370 Author Index

May 1, Number 9

PERSPECTIVES IN CANCER RESEARCH 2419 Allelotype Analysis in Osteosarcomas: Frequent Allele Loss on 3q, 2478 Allelotype of Non-Small Cell Lung Carcinoma--Comparison be- 13q, 17p, and 18q, Toshikazu Yamaguchi, Junya Toguchida. Takao tween Loss of Heterozygosity in Sqnamons Cell Carcinoma and 2371 The Evolution of Paradigms for the Mnnagemont of Breast Cancer: Yamamuro. Yoshihiko Kotoura, Norihiko Takada, Nonyoshi Adenocarcinoma. Eiju Tsuchiya, Yusukr Nakamura+ Siu-Yuhe Wang, Ken Nakagawa, Shigehiro Tsnchiya, Haruo Sugano, and A Personal Perspective. Bernard Fisher. Kawaguchi, Yasuhiko Kaneko, Yusukc Nakamura, Masao S. Sasaki. and Kanji Ishizaki. Tomoyuki Kitagawa.

2424 Antitumor Activity of N,N'-Bis(ethyl)spermine Homolognes against 2482 Nuclear Type II Sites and Malignant Cell Proliferation: Inhibition Human MALME-3 Melanoma Xenngrafts. Ralph J. BernackL by 2,6-Bis-benzylidenecyclobexanones. Barry M. Markaverich. Raymond J. Bargeron, and Carl W, Porter. Thomas H, Sehauweker. Rebecca R. Gregory, Manju Varma, Francis S. Kittrell, Daniel Medina, and Rajender S. Varma. 2384 Retinoic Acid Inhibition of Serum-induced c-los Transcription in a 2431 Stealth Liposomes: An Improved Sustained Release System for l-#- Fibrosarcoma Cell Line. Pamela Jaffey. Lee-Nien L. Chart, Jinyi D-Arabiaofuraaosylcytosine. Theresa M, Allen, Tarun Mehra. 2489 Transcriptional and Posltraascriptionni Activation of Urnkinuse Shao, Jiirgen Schneider-Schaulies, and Tch-shcng Chart. Christian Hansen, and Yeen Chcel Chin. Plasminogen Activator Gene Expression in Metastatic Tumor Cells. Bent R. Henderson. William P. Tansey, Susan M. Phillips, lan A. 2389 Resistance to l-#-D-Arabinofuranosylcytosine in Human T-Lympho- 2440 Loearegional Administration of Etoposide, but ant of Interleukin 2, Ramshaw, and Richard F. Kefford. blasts Mediated by Mutations within the Denxycytidine Kinase Gene. Facilitates Active Specific Immunization in Guinea Pigs with Ad- Janet K. Owens, Donna S. Shewach, Buddy Ullmam and Beverly S. vanced Carcinoma. Anke M. E. Claessen, Elisabeth Bloemena. Mitchell. 2497 Binding Parameters and Idintypic Profile of the Whole Immonnglob- Herman Bnl, Chris J. L. M. Meijcr. and Rik J. Scheper. ulin and Fob' Fragments of Marine Monodonal Antibody to Distinct 2394 Anti-CD3 Monoclonal Antibody Treatment of Patients with CDS- Determinants of the Human High Molecular Weight-Melanoma Negative Tumors: A Phase IA/B Study. Walter J. Urba. Cynthia 2447 Pesticides and Other Agricultural Risk Factors for Non-Hodgkin's Lymphoma among Men in Iowa and Minnesota. Kenneth P. Cantor, Associated Antigen. Massimo Temponi. Alien M. Gold. and Soldano Ewel. William Kopp, John W. Smith II, Ronald G. Stcis, Aaron Blair, George Everett, Robert Gibson. Leon F. Burmcistcr, Ferrone. Jonathan D. Ashwelt, Stephen P. Creekmore, Jeffrey Rossio, Mario Linda M Brown, Leonard Schuman, and Fred R. Dick. Sznol, William Sharfman, Robert Fenton, John Janik, Tbelma 2504 Unhydrolyzable Analogues of Adenosine 3':5'-Monophosphntu Watson, Joy Beveridge, and Dan L, Longo. 2456 Modulation of O~-Alkylgnanine-DNA Alkyltransferase-mediated Demonstrating Growth Inhibition and Differentiation in Human Can- Carmustine Resistance Using Streptozotocin: A Phase I Trial. cer Cells. Hiroshi Yokozaki, Giampaolo Tortora, Stefano Pope, Erik 2402 Inhibition of 7,12-Dimethylbenz(n)anthracene-indoced Tumors nod Timothy J. Panella, David C. Smith, S. Clifford Schold, Miriam P+ Maronde, Hans-Gotffried Genieser, Bernd Jastorff, and Yoon S. DNA Anduet Formation in the Mammary Glands of Female Spregne- Rogers, Eric P. Winer, Robert L. Fine, Jeffrey Crawford, James E. Cho-Chung. Dawley Rats by the Synthetic Organosckninm Compound, Hcrndon IL and Donald L. Trump. 1,4-Phenylenebis(methylone)selonocyanate. Karam EI-Bayoumy, 2509 Tumor Cell Kinetics following Antinenplastic Ether Phospholipid Voung-Heum Chae, Pramod Upadhyaya+ Carol Meschter, 2460 Amplification and Expression of the bcl-I Gene in Human Solid Treatment. Paola Principe, Carole Sidoti. and Pierre Braquet, Leonard A, Cohen, and Bandaru S. Ruddy. Tumor Cell Lines. John B. Faust and Timothy C. Mecker. 2516 Selective Loss of Gincocortkoid-dependeat Responses in a Variant 2408 Pharmacokinetics and Toxkity of Continuous Infusion (6S)-Folink 2464 Carcinogenic Potency of Alkyiating Agents in Rodents and Humans+ of the DDT~MF-2 Tumor Cell Line. William J. Hendry Ill Reza Acid and Bolus 5-Floorouracil in Patients with Advanced Cancer. Robert L. Dedrick and Paul F. Morrison. Edward M. Newman, Steven A. Akman, Jonathan S. Harrison, Hakkak. and Lawrence E. Cornett. Lucille A. Leong, Kim A. Margolin, Robert J. Morgan, James W. 2468 Heterogeneity among Epstein-Barr Virus-seropositive Donors in the 2523 Molecular Analysis of Deletion of the Short Arm of Chromosome 9 Raschko, George Somlo, Chul W. Ahn, and James H. Doroshow. Generation of Immonobiastic B-Cell Lymphomas in SCID Mice Receiving Human Peripheral Blood Leukocyte Grafts. Gast6n R. in Human Gliomas. Olufunmilayo I. OIopade, Robert B. Jenkins. 2413 Inhibition of Cancer Cell Growth by Calcium Channel Antagonists Picchio, Ryo Kobayashi, Marybeth Kirven, Stephen M. Baird. David T, Ransom, Kathleen Malik, Helen Pomykala, Tsutomu in the Athymic Mouse. J. M. Taylor and R. U Simpson. Thomas J. Kipps, and Donald E+ Mosier. Nobori. J'anet M. Cowan, Janet D. Rowley, and Manuel O. Diaz.

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2530 Induction of Expression of Genes Encoding Components of the 2575 Nephrobinstomns in the Japanese Eel, Angnillajaponlca Temminck 2616 Frequent Loss of Expression of the Potential Tumor Suppressor Respiratory Burst Oxidase during Differentiation of Human Myeloid and Sehlegel. Prince Masahito. Takatoshi lshikawa. Nobuaki Gene DCC in Ductal Pancreatic Adenocarcinoma.Martin W. H6hne, Cell Lines Induced by Tumor Necrosis Factor and "r-lnterferon. Okamoto, and Haroo Sugano. Marc-E. Halatsch, Georg F. Kahl, and Rolf J. Weinel. Jean W. Gupta, Marek Kubin, Lisa Harlman, Marco Cassatella, and Giorgio Trinchieri. 2580 Tumor-inhibitory Mouuelonol Antibodies to the HER-2/Neu RecelV tue Induce Differentiation of Human Breast Cancer Cells. Sarah S. 2620 Accelerated Declining Tendency of Human T-Cell Leukemia Virus 2538 Sustained Release Formulations of Luteiniztng Hormone-releosing Bacus, liana Stancovski, Eliezer Huberman, Dot Chin, Esther Type 1 Carrier Rates among Younger Blood Donors in Kumamoto, Hormone Antagonist SB-75 Inhibit Proliferation and Enhance Apop- Hurwitz, Gordon B. Mills, Axel Ullrich, Michael Sela, and Yosef Japan. Shigeru Oguma, Yumiko Imamura, Yukihiko Kusumoto, totic Cell Death of Human Prostate Carcinoma (PC-82) in Male Yarden. Yoko Nishimura, Kazunari Yamaguchi, Kiyoshi Takatsuki, Shinkan Nude Mice. Tommie W. Redding, Andrew V. Schally, Sinisa Tokudome, and Minoru Okuma. Radulovic, Slobodan Milovanovic, Karoly Szepeshazi, and John T. 2590 Metaphase and Interphese Cytogenetics with Alu-PCR-amplified Isaacs. Yeast Artificial Chromosome Clones Containing the BCR Geue and the Protnoncogeues c-raf-l, corms, and c-erbB-2. Christoph 2624 Detection of Frequent Allelic Loss on Proximal Chromosome 17q in 2545 Interaction of an ~-Meinnocyte-stimuinting Hormone-Diphtheria Lengauer, Harold C. Riethman, Michael R. Speicher, Masafumi Sporadic Breast Carcinoma Using Mlerosatellile Length Polymor- Toxin Mel- Fusion Protein with Melanotropin Receptors in Human Taniwaki. David Konecki, Eric D. Green, Reinhard Becher, phisma. P. A. Futreal, P. Soderkvist, J. R. Marks, J. D. Iglehart, C. anoma Metastases. Jeffrey B. Tatro, Zilong Wen, Margaret L. Maynard V. Olson, and Thomas Cremer. Coehrsn, J. C. Barrett, and R. W. Wiseman. Entwistle, Michael B. Atkins, Thomas J. Smith. Seymour Reichlin. and John R. Murphy. 2597 c-m~c, c-r and IO-67 Expression in Normal Breast Tissue and in Invosive and Noninvusive Breast Carcinoma. Zlatko P. Pavelic, 2549 Reactivation of Insulin-like Growth Factor II during Hepatuearcin- Ljiljana Pavelic, Elyse E. Lower, Markus Gapany, Sabina Gapany, 2628 Soluble Intercellular Adhesion Molecule 1 Is Released by Human ogenesis in Trausgenlc Mice Suggests a Role in Malignant Growth. Edward A. Barker, and Harvey D. Preisler. Melanoma Cells and Is Associated with Tumor Growth in Nude Peter Schirmacher, W. A. Held, D. Yang, F. V. Chisari, Yusuf Mice. Raffaella Giavazzi, Renato G. S. Chirivi, Angela Garofalo, Rustum, and C. E. Rogler. 2603 Qnontitation of Human Tumor-reactive Monuelonal Antibody 16.88 Alessandro Rambaldi, inn Herningway, Rod Pigott, and Andy J. H. in the Circuintiou and Localization of 16.88 in Colorectal Metastatic Gearing. 2557 Phosphetase Inhibitors Modulate the Growth-reguintory Effects of Tumor Tissue Using Muriue Antiidiotypic Antibodies. W. C. Human Tumor Necrosis Factor on Tumor and Normal Cells. Klara Taddei-Peters, M. V. Haspel, P. Vente, J. L. Murray, K. R. Cleary. Totpal, Sudha Agarwal, and Bharat B. Aggarwal. B. Levin, E. M. Paris, N. Pomato, J. H. Murray, D. Weidman. 2563 Tumor Selective Reactivity of a Mouocionol Antibody Prepared M. G. Hanna, Jr.. and R. P. McCabe. against a Recombinant Peptide Derived from the DF3 Hunum Breast Carcinoma-ossodated Antigen. Lucien Perey, Daniel F. Hayes, Peter 2631 Announcements Maimonis, Miyako Abe, Carl O'Hara. and Donald W. Kufe. Eighty-Third Annual Meeting of the AACR AACR Special Conferences in Cancer Research 2569 Rndinimmunoscintigraphy of Head and Neck Cancer Using "~Tc- ADVANCES IN BRIEF Future Annual Meetings of the AACR labeled Mouoclomtl Antibody E48 F(ab')2. Guus A. M. S. Recent Deaths van Dongen, Hein Leverstein, Jan C. Roos, Jasper J. Quak, 2610 p53 and Kirsten-rgr Mutations in Human Mesothelioma Cell Lines. Calendar of Events Michiel W. M. van den Brekel, Arthur van Lingen, Hame J. M. R. A. Metcalf, J. A. Welsh, W. P. Bennett, M. B. Seddon, T. A. Martens, Jonas A. Castelijns, Gerard W. M. Visser, Chris J. L. M. Lehman, K. Pelin. K. Linnainman, L. Tammilehto. K. Mattson, Meijer, Gemt J. J. Teule, and Gordon B. Snow. B. I. Gerwin, and C. C. Hams. 2634 Author Index

May 1, Number 9, Supplement

Acknowledgment to Supplement Reviewers ...... 2638s

Overview James L. Mulshine ...... 2639s

Methods and Strategies in Lung Cancer Control Andre Castonguay ...... 2641 s New Approaches to Treating Early Lung Cancer Jack A. Roth ...... 2652s Application of Molecular Genetics to the Early Diagnosis and Screening of Lung Cancer Michael J, Birrer and Powel H. Brown ...... 2658s Clinical Significance of ras Oncogene Activation in Human Lung Cancer Sjoerd Rodenhuis and Robert J. C. Slebos ...... 2665s Primary Lung Tumors in Mice: An Experimentally Manipulable Model of Human Adenocarcinoma Alvin M. Malkinson ...... 2670s Induction and Spontaneous Regression of Intense Pulmonary Neuroendocrine Cell Differentiation in a Model of Preneoplastic Lung Injury Mary E. Sunday and Christopher G. Willett ...... 2677s Bronchial and Pulmonary Carcinogenesis at Focal Sites in Dogs and Hamsters John R. Benfield and William G. Hammond ...... 2687s Lung Cancer Detection and Prevention: Evidence for an Interaction between Smoking and Genetic Predispo- sition Thomas A. Sellers, John D. Potter, Joan E. Bailey-Wilson. Stephen S. Rich, Henry Rothschild, and Robert C. Elston ...... 2694s DNA and Hemoglobin Adducts as Markers of Metabolic Activation of Tobacco-spec(/~c Carcinogens Peter G. Foiles, Sharon E. Murphy, Lisa A. Peterson, Steven G. Carmella, and Stephen S, Hecht ... 2698s Chromosome Abnormalities in Human Non-Small Cell Lung Cancer Joseph R. Testa and Jill M. Siegfried ...... 2702s Determination of Biomarkers for Intermediate End Points in Chemoprevention Trials Jin S. Lee, Scott M. Lippman, Waun K. Hong. Jae Y. Ro, Sun Y. Kim, Reuben Lotan. and Walter N. Hittelman ...... 2707s Considerations i'n Bringing a Cancer Biomarker to Clinical Application Melvyn S. Tockman, Prabodh K. Gupta, Norman J. Pressman, and James L. Mulshine ...... 271 Is New Potential Chemopreventive Agents for Lung Carcinogenesis o[ Tobacco-specific Nitrosamine Fung-Lung Chung, Mark A. Morse, and Karin I. Eklind ...... 2719s Nitrosamine-induced Lung Carcinogenesis and Ca"+/Calmodulin Antagonists Hildegard M. Schtiller ...... 2723s Urinart' Levels of Bombesin-like Peptides in Asymptomatic Cigarette Smokers: ,4 Potential Risk Marker for Smoking-related Diseases Samuel M. Aguayo, Talmadge E. King, Jr., Madeleine A. Kane, Karen M. Sherritt. Wayne Silvers, Louise M. Nett, Thomas L. Petty, and York E. Miller ...... 2727s Neuromedin B Is Present in Lung Cancer Cell Lines G. Giaccone, J. Battey, A. F. Gazdar. H. Oie, M. Draoui, and T. W. Moody ...... 2732s Growth of Small Cell Lung Cancer Cells; Stimulation by Multiple Neuropeptides and Inhibition by Broad Spectrum Antagonists in Vitro and in Vivo Tariq Sethi, Simon Langdon, John Smyth, and Enrique Rozengurt ...... 2737s The Correct Dose." Pharmacologically Guided End Point for Anti-Growth Factor Therapy James L. Mulshine. Noriyuki Shuke, Farhad Daghighian, Jorge Carrascluillo, Bimal Ghosh, Thomas Walsh, Ingalill Avis. James C. Reynolds, Frank Cuttitta, and Steven M. Larson ...... 2743s Early Intervention in Cancer Using Monoclonal Antibodies and Other Biological Ligands. Micropharmacology and the "Binding Site Barrier" John N. Weinstein and William van Osdol ...... 2747s The Clinical Evaluation of Cancer Chemoprevention Agents. Defining and Contrasting Phase I. I1, and III Objectives Gary E. Goodman ...... 2752s Chemoprevention Strategies.for Lung and Upper Aerodigestive Tract Cancer Steven E. Benner, Scott M. Lippman, and Waun Ki Hong ...... 2758s

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Prectinical Research in Earl)" Lung Cance~v Breakout Group R~Tort M. Mabry, T. W, Moody, and S. B. Baylin ...... 2764s Diagnostic Research: Breakout Group Report James k. Mulshine and Melvyn S. Tockman ...... 2766s Intervention Approaches in Early Lung Cancer and Premalignant Disease- Breakout Group Report Daniel C. lhde and Scott kippman ...... 2767s

List of Participants ...... 276%

May 15. Number 10

2771 Therapy of an Animal Model of tiuman Gastric Cancer Using a 2862 Identification and Characterization of a Specific Autoantiphosphati- 2957 Expression of N,myc, c-myc, and MDR-1 Proteins in Newly Estab- Combination of Anti-erbB-2 Monoclonal Antibodies. Philip G. dylinositol Immune Response during the Time Course of Benzo(a)- lished Neuroblastoma Cell Lines: A Study by Immunnfluorescenee Kasprzyk. Sun Uk Song. Pier Paolo Di Fiore. and C. Richter King. pyrene-iuduced Malignant Tumors in Female Sprague-Dawle) Rats. Staining and Flow Cytometry. Yair Gazitt, Yun Ju He, Lee Chang. S. Faiderbe, J. L. Chagnaud, and M. Geflhrd. 2777 Clinical Implications of K-ras Mutations in Malignant Epithelial Shannon Koza. Diann Fisk, and John Graham-Pole. Tumors of the Endometrium. Hidemitsu Mizuuchi, Suhail Nasim, 2866 In Vitro Mutational Specificity of Cisplatio in the Iluman tlypoxan- 2966 Extracellular Matrix Receptors and Mouse Skin Carcinogenesis: Ryuichi Kudo, Sloven G. Silverberg. Samuel Greenhouse, and thine Guanine Pbosphoribosyltransfecase Gene. Neal F. Cariello, Altered Expression Linked to Appearance of Early Markers of Carleton T. Garrett. James A. Swenberg. and Thomas R. Skopek. Tumor Progression. Tamar Tennenhaum, Stuart H. Yuspa. Atul Grover, Vincent Castronovo, Mark E. SobeL Yoshihiko Yamada. 2782 Development and Characterization of a WEHI-3B D + Monomyelo- 2874 Relationship of VP-16 to the Classical Multidrug Resistance Phe- and Luigi M. De Luca. cytic Leukemia Cell Line Resistant to Novobiocin and Cross-Resist- not,Ht~e. Maxwell Sehested. Ellen Friche, Peter Buhl Jensen. and ant to Other Topoisomerase If-targeted Drugs. Germana Rappa, Erland J. F. Demant. Aurelio Lodco, and Alan C. Sartorelli. 2880 Inhibition of Friend Leukemia (Tell Visceral Metastasos by a Ne~ 2791 Evaluation of Metastatic Human Tumor Burden and Response to Monoclonal Antibody and Role of the Immune System of the Host Therapy in a Nude Mouse Xenograf! Model Using a Molecular in its Action. Arturo Sala. Ion Gresser. Daniele Chassoux, Chantal Probe for Repetitive Human DNA Sequences. Robert H. Shoemaker, Maury, Laura Santodonato. Pierre Eid. Marie-Therese Maunour3, ADVANCES IN BRIEF Anne M. Smythe, Lin Wu, Michael S. Balaschak. and Michael R. Stefano Barca. Maurizio Cianfdglia. and Filippo BelarddlL Boyd. 2977 Hepatocarcinogenieity of Dehydroepiandrosterone in the Rat. M 2890 Metabolic Properties and Photosensitizing Responsiveness of Mono- Sambasi~a Rap. V. Subbarao. Anjana V. Yeldandi. and Janardan K. 2797 Cinchonine, a Potent Effiux Inhibitor to Circumvent Anthracyciine I.-aspartyl Chlorin e~. in a Mouse Tumor Model. Angola Ferrario. Reddy. Resistance in Vivo. Philippe Genne. Marie Th~r~se Dimanche- David Kessel. and Charles J. Gomer. Boitrel, Roland Yves Mauvernay, Gilles Gutierrez, Olivier 2980 Amplification and Expression of the Human Cyclin D Gone in Duchamp, Jean-Michel Petit, Francois Martin, and Bruno Chauffert. 2894 Phase 1 and Pharmacokinetic Study of Rhizoxin. D, Bissett, M. A. Esophageal Cancer. Wet Jiang. Scott M. Kahn, Naohiro Tomita, Yu-Jing Zhang, Shih-Hsin Lu, and I. Bernard Weinstein. Graham. A. Setanoians. G. A. Chadwick. P. Wilson. I. Koier, R. 2802 Cell Cycle Analysis of p26-BCL-2 Protein Levels in Proliferating Henrar. G. Schwartsmann. J. Cassid~. S. B. Kaye, and D. J. Kerr. Lymphoma and Leukemia Cell Lines. John C. Reed. Shigeki Tanaka, 2984 Inherited p53 Gene Mutations in Breast Cancer. David Sidransky. Takashi Tokino, Kathy Helzlsouer, Barbara Zehnbauer, Grog and Michael Cuddy. 2899 Correlation I~tween Dihydrupyrimidine Dehydrogenase Activit) in Rausch, Bonnie Shelton, Laura Prestigiacomo, Bert Vogelstein. and Peripheral Mononur Cells and Systemic Clearance of Fluoro- 2806 Perturbations ofCellnlar Aeylation Processes by the Synthetic Alkyl- Nancy Davidson. uracil in Cancer Patients. Ronald A. Fleming, Gerard Milano, lysephospholipid I -O-Pet udecyl-2-O-met hylglycero-3-pbosphocho- Antoine Thyss. Made-Christine Etienne. Nicole Ren~e. Maarice 2987 p53 Mutations Are Associated with 17p Allelic Loss in Grade II and line Do Not Correlate with Inhibition of Proliferation of MCF7 and Schneider. and Francois Demard. Grade Ill Astrocytoma. Andreas yon Deimling. Robert H. Eibl, "P84 Cell Lines. Xiaoli Lu and Gilbert Arthur. Hiroko OLgaki. David N. Louis, Klaus yon Ammon. lver Petersen, 2903 ras Gene Mutations as a Prognostic Marker in Adenocarcinnma of 2813 The Differential Sosceptibility of A427 and A549 Cell Lines to the Paul Kleihues. Richard Y. Chung. Otmar D. Wiestler, and Bernd R. the Human Lung without l,,.mph Node Metastasis. Kenji Sugio. Seizinger. Growth-inhibitory Effects of ET-18-OCH3 DOCs Not Correlate with Teruyoshi Ishida. Hideki Yoko~,ama. Takashi Indue. Keizo the Relalive Effects of the Alkyl-lysophospholipid on the incorpo- Sogimachi, and Takehiko Sasazuki. 2991 The Retinoblastoma Gone in Breast Cancer: Allele I,oss Is Not ration of Fatty Acids into Cellular Phospholipids. Xiaoli Lu and Correlated ,~ilh Loss of Gene Protein Expression. Ake Borg. Qtu- Gilbert Arthur. 2907 Intraeellular Catabolism of Rudiolabeled Anti-u Antibodies b.~ Ma- Xia Zhang. Per Aim. Hfikan OIsson, and Gunilla Sellbergr lignant B-Cells. Francis Geissler. Susao K. Anderson. Prasanna 2818 Antitumor Quinolones with Mammalian Topoisomerase II Mediated Venkatesan. and Oliver Press. 2995 Selective Mutation of Codons 204 and 213 of the p53 Gene in Rat DNA Cleavage Activity. Yoshinori Yamashita, Tadashi Ashizawa, Tumors Induced by Alkylating N-Nitroso Compounds. Hiroko Makoto Morimoto, Jiro Hosomi, and Hirofumi Nakano. 2916 Decreased Expression of E-Cadherin in the Progression of Rat Ohgaki. Gordon C. Hard, Norio Hirota, Akihiko Maekawa. Prostatic Cancer. Marion J. G. Bussemakers. Reindert J. A. Michihito Takahashi. and Paul Kleihues, 2823 Multiple Oncogenes add Tumor Suppressor Genes Are Structurally van MoorseIaar, Laurence A. Giroldi, Tomohiko Ichikawa, John T. and Functionally Intact during Hepatocarcinogenesis in Hepatitis B lsaaes, Masatoshi TakeichL Frans M. J. Debru)ne, and Jack A. Virus Trunsgenic Mice. Claudio Pasquinelli, Kasibha0a Bhavani. Schalken. and Francis V. Chisari. 2923 Mueiu Gel Formed b~ Tumorigenic ~luamous Lung Carcinoma Cells 2830 Murine Pharmacokinetics und Metabolism of Penelomedine [3,5- Has Le'-X Oligosaccharides and Excludes Antibodies from Coder- Dichloro-2,4-dimetboxy-6-(trichloromethylJpyridine, NSC 338720]. lying Cells. Patricia L. Stranahan, Rand3 B, Hov, ard. Os~ald LETTER TO TilE EDITOR Joel M. Reid, Dane A. Mathiesen, Linda M. Benson. Mary J, KuffeL Pfenninger, Michael E. Cowen. Michael R. Johnston. and Oa,,id E. and Matthew M. Ames. Pettijohn. 2999 Correspondence re: G. Cimino et a/., Cloning of ALL-l, the Locus Involved in Leukemias with the t(4; I I){q21 ;q23), 1(9; i 1X p22;q23), 2835 Selective Inhibition of Phosphatidylinositol Phospholipase C by C~,- 2931 In Vivo Circumvention of Iluman Colon Carcinoma Resistance to and t(I 1:19Xq23;p13)Chromosome Translocations. Cancer Res., 51: totoxic Ether Lipid Analogues. G. Pov, is. M. J. Seewald, C. Gratas. Bleomyein. Jitesh P. Jan . Jehang r S Mis ~. GOd "fre~. Morris Paul 6712-6714, 1991. Janet D. Rowlc3 and Manuel O. Diaz. D. Molder. J. Riebow. and E. J. Modest. Davies, John S. Lazo. and Said M. Sebtt. 2841 Effects of Liarozole, a New Antitumozal Compound, on Retinoic 2938 A Phenotypically and KaryoDpicalls Stable Human Thyroid Epithe- Acid-induced Inhibition of Cell Growth and on Retinoic Acid Metab- lial Line Conditionall~ Immortalized b~ SV40 I.arge T Antigen. olism in MCF-7 Human Breast Cancer Cells. Waiter Wouters. Jacky Fiona S. Wyllie. Jane A. Bond. Tim Day, son. Denise White, Rose van Dun, Ann Dillen, Marie.Claire Coene. Willy Cools, and Roland Davies. and David W~,nford-Thomas. De Coster. 3000 Announcements 2946 Persistent CIonal Areas and Clonal Expansion in Barrett's Esopha- Eightj-Third Annual Meeting of the AACR 2847 Expression of Nuclear Envelope Lamios A and C in Human Myeloid gus. Wend'. H. Raskind, Thomas Norwood. Douglas S. Le'.ine. AACR Special Conferences in Cancer Research Leukemias. Scott H. Kaufmann. Rodger C. Haggitt. Peter S. Rabino~itch, and Brian J Reid. Future Annual Meetings of the AACR Recent Deaths 2854 Tbermotolerance in the Absence of luduced Heat Shock Proteins in 2951 Expression Pattern of ~-Protein Kinase C in lluman Astroc~tomas Calendar of E~ents a Murine Lympboma. Barbara Fisher, Peggy, Kraft. George M. Hahn. Indicates a Role in Malignant Progression. UA'borah L. Benzil. and Robin L. Anderson. Sydnc~ D. Finkelstein, Mel H. Epstein. and Paul W Fmch. ,M}03 Author Index

June I, Number 11

3005 Polyinosinic-Polycytidylic Acid Complexed with Poly-L-lysine and 3029 Multidrug-resistant Pbenot~pe of Disease-oriented Panels of Iluman 3052 Granuloc)te Colon~-stimulating Factor Receptors on Iluman .~eute Carboxymethyicellulose in Combination with Interleukin 2 in Pa- Tumor Cell IJnes Used for Antieancer Drug .Sk'reening. Lin Wu. Leukemia: Biphenotypic Leukemic Cells Possess Granulocyte Col- tients with Cancer: Clinical and Immunological Effects. Cynthia H. Anne M. Sm~.the. Sherman F. Stins,:m. Leslie A Mullcndorc. Anne ony-stimulating Factor Receptors. Kazu}a Shimoda, Scuchi Ewel, Walter J. Urba. William C. Kopp. John W, Smith 11, Ronald Monks. Dominic A. Scudiero. Kenneth D Pau[l. Antoms D. Okamura. Naoki Harada, Wataru lkematsu. Sciji Kondo Chi':,uki G. Stets, Jeffrey L. Rossio, Dan L. Longo. Mary, Jane Jones. Koutsoukos. Lav, rence V. Rubinstcin, Mlchael R Bo':,d. and Robert Ka',~asaki, Takeshi Tanaka. Tetsuya Etou. Kouichi Akasht, Takashi W Gregory Alvord, Carl M. Pinsky, Joy M, Beveridge. Karen L. H Shoemaker. Okamura. Tsuncfumi Shibuya, Mine Harada, and Yoshi:, uki Niho. McNitt. and Stephen P. Creekmore. 3035 Comparative Metabolism in Vitroofa No~elCareioogenic Pol)cyclie 3011 Stimulation of Anchorage-independent Cell Growth by Endotbelin in Aromatic H) drocarbon, 1,2,3,4-Tetrah}dro-7.12-dimet h.qbenz[a}an- 3056 Efficacy of an Ami-CD7-Riein A Chain Immunoconjugale in a No~el NRK 49F Cells. Masatoshi Kosuhara. Ken Yamaguchi, Masaru lhracene, and Its Tso Regioisomeric B-Ring Fluoro Analogues. Murine Model of Iluman T-Cell I,eukemia. Diannc M. Fish~iM Kuranami, Ai Suzaki, Shiro lshikawa. Hanlim Moon. Isamu AdachL Stephen J. Rinderle, Shaun D. Black, Pradecp K Sharma. and Sharon Aberle. Susan L, Bernhard. and Ada tE C. Kung Shingo Hori, and Shunnosuke Handa. Donald T. Witiak. 3043 Endogenous Receptor-bouud l.rokinase Mediates Tissue Inlasion of 3063 Changes in Actin and Actin-binding Proteins during the Differentia- 3015 Modulation of Trenimon-induced Cytotoxicity by DT-Diaphorase in the Iluman Lung Carcinoma Cell I,ines A549 and Calu-I. tion of 111760 l,eukemia Ceils. Mun-Fai l.eung, Thomas S. Lin. and Isolated Rat Hepatocytes under Aerobic versus Hypoxic Conditions. Bruckner. A. E. Filderman, J. C. Km:hhcimer, B. R. Binder. and Alan C, Sartorelli. Jos~ M. Silva, D. N. Ramakrishna Rap, and Peter J. O'Bfien. H, G. Remold.

3022 The Amitumor Effects of the Quinoline-3-carboxamide, Linomide, 3048 llerbal Medicine Use, Epstein-Barr Virus, and Risk of %asophar.,.n- Increased Expression of tluman Ribosonml Phosphoprotein P(I Mes- on Dunning R-3327 Rat Prostatic Cancers. Tomohiko lchikawa, goal Carcinoma. Allan Hildeshcim, Sheila WesL Erne~ao DeVe,.ra. senger RN.'~ in llepatocellular Carcinoma and Colon Carcinoma. John C. Lamb, Per I. Christensson, Beryl Hartley-Asp, and John T. Maria F. De Gazman. Adonis Jurado. Carol Jones Joko Imai. and Graham F. Barnard. Ra~,rnond J. Staniunas. Shideng Bao. Kcn-ichi Isaacs. Yorio Hinuma. Mafune. Glenn D Steele, Jr.. John L. Gollan. and I an Bo Chcn

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. CONTENTS OF VOLUME 52

3073 Influence of the H-ras Oncogene ou Radiation Responses of a Rat 3138 Slalyl Lewis~ Antigen as Defined by Monoclonal Antibody AM-3 Is ADVANCES IN BRIEF Rhabdomyosarcoma Cell Line. A. F. Hermens and P. A. J. a Marker of Dysplasia in the Colonic Adenoma-Carcinoma Sequence. 3220 p53 Mutatious in Human Hepatocellular Carcinomas from Germany. Bentvelzen. Franz-Georg Hanisch, Chrisloph Hanski, and Akira Hasegawa. Stefan Kress, Uli-Rfidiger Jahn, Albrecht Buchmann, Peter 3083 Overexpression of the ras-related rub2 Gone Product in Peripberal 3145 Development of an in Vitro Model to Study Curcinogen-induced Bannasch, and Michael Schwarz. Neoplastic Progression of Initiated Mouse Epidermal Cells. David Blood Mononnelenr Cells from Patients with Hematological and 3224 Ampbiregulin Messenger RNA Is Elevated in Psoriatic Epidermis Morgan, David Wclty, Adam Glick, David Greenhalgh. Henry Solid Neoplasms. St~phane Culine, Nicole HonorS, Armand and Gastroinestinal Carcinomas. Paul W. Cook, Mark R. Pittelkow, Hennings, and Stuart H. Yuspa. Tavitian, and Birgitta Olofsson. Winifred W. Keeblc, Ramona Graves-DeaL Robert J. Coffey, Jr., and Gary D. Shipley. 3089 Expression of the Epidermal Growth Factor Receptor in Human 3157 Drug Transport Mechanisms in HL60 Cells Isolated for Resistance Small Cell Lung Cancer Cell Lines. Lars Damstrup, K~re Rygaard, to Adriamycin: Evidence for Nuclear Drag Accumulation and Redis- 3228 Radioseositization of Human Tumor Cells with Levamisole, Cherie Mogens Spang-Thomsen, and Hans Skovgaard Poulsen. tribution in Resistant Cells. David Marquardt and Melvin S. Center. J. Hayostek and Thomas M. Koval, 3164 Role of the Alveolar Type II Cell in the Development and Progressiou 3231 The APC Gene, Responsible for Familial Adenomatous Polyposis, 3094 A Third Wilms' Tumor Locus on Chromosome 16q. Marion A. Maw, of Pulmonary Tumors Induced by 4~Methylnitrusamino)-1-(3- Is Mulated in Human Gastric Cancer. Akira Horii, Shuichi Paul E, Grundy. Lynn J. Millow, Michael R. Eccles, Roseanne S. pyridyl)-l-butanone in the A/J Mouse. Steven A. Belinsky, Theodora Nakatsuru. Yasuo Miyoshi, Shigetoshi Ichli, Hiroki Nagase, Yo Dunn, Peter J. Smith, Andrew P. Feinberg, Dave J. Law, Malcolm R. Devereux, Julie F. Foley'. Robert R, Maronpot, and Marshall W. Kato, Akio Yanagisawa, and Yusuke Nakamura. C. Paterson, Perry E. Tclzerow, David F. Callen, Andrew D. Anderson. Thompson, Robert I. Richards, and Anthony E. Reeve. 3234 Screening for Germ Line TP53 Mutations iu Breast Cancer Patients. 3174 Acquisition of a Tumorigenic Phenotype by a Rat Ventral Prostate Anne-Lise Borresen, Tone Ikdahl Andersen, Judy Garber, No~le Barbier-Piraux, Steinunn Thorlacius, Jorunn Ey06rd, Lars Ottestad, 3099 Frequent Loss of Heterozygosity at the DCC Locus in Gastric Epithelial Cell Line Expressing a Transfected Activuted neu Onto- gene. Robert A. Sikes and Leland W. K, Chung, Birgitte Smith-Serensen, Eivind Hovig, David Malkin, and Stephen Cancer. Shinya Uchino, Hitoshi Tsuda, Masayuki Noguchi, Jun H. Friend. Yokota, Masaaki Terada, Takao Saito, Miehio Kobayashi, Takashi 3182 Potential Autocrine Role of Insulin-like Growth Factor II during Sugimura, and Setsuo Hirohashi. 3237 Nieotinamide Can Lower Tumor Interstitial Fluid Pressure: Mecha- Suramin-induced Differentiation of Human Colonic Adenocarcinoma nistic and Therapeutic Implications. lntae Lee, Yves Boucher, and Cell Line HT29-1M. Gilbert J. Pommicr, Fran~:oise L. Garrnuste, 3103 Pazatbyroid Hormone-like Peptide Shares Features with Members Rakesh K. Jain. Fatima El Atiq. Monique Roccabianea, Jacques L. Marvaldi. and of the Early Response Gone Family: Rapid Induction by Serum, Maryse M. Rcmaclc-Bonnet. 3241 Increased Accumulation of Drugs in Mnltidrug-resistant Cells ln- Growth Factors, and Cycloheximide. E. Tracey AIlinson and Daniel duced by Liposomes. Leonard Warren, Jean-Claude Jardillier, Anna J. Drucker. 3189 Antitumor Effects of B3-PE and B3-LysPE40 iu a Nude Mouse Ma[arska, and Marie-Genevieve Akeli. Model of Human Breast Cancer and the Evnlnation of B3-PE Tox- 3110 Characterization of a Cispiatin-resistant Human Ovarian Carcinoma icity in Monkeys. Lee H, Pal. Janendra K. Batra. David J. FitzGerald, Cell Line Expressing Cross-Resistuoce to 5-FInorouracil but Collar- Mark C. Willingham. and Ira Pastan. oral Sensitivity to Methotrexate. Bridget T. Hill, Sharon A, Shellard, Louise K. Hosking, Wolfram C. M. Dempke, Anne Marie J. 3194 Tumor Necrosis Factor as an Autocrine Growth Factor for Neuro- Fichtinger-Schepman, Takeshi Tone. Kevin J. Scanlon, and Richard blastoma. Evelyne Goillot, Valerie Combaret. Ruth Ladcnstein, MEETING REPORT D. H. Whelan. Daniel Baubet Jean-Yves Blay Thierry Phi p and Marie C. Favrot. 3246 Third Annual Pezcoller Symoosinm: Tumor Suppressor Genes. 3119 Sensitization of Human Cervical Carcinoma Cells to cis-Diammine- 3201 Gaoglioside, Adhesion Molecule, and HLA Antigen Expression in David Livingston and Enrico Mihich. dichloropiatinum(II) by Bryostutin I. Alakananda Basu and John S. Basal Cell Carcinoma Lesions. Toshiro Kageshita, Tomomichi Ono, Lazo. Shyunji Hirai, Akira Yoshii, Toru Kimura, Hideki Nakakuma, Kentaro Horikawa, Kiyoshi Takatsuki. and Soldano Ferrone. 3125 Differential Effects of Amsacrine and Epipndophyllotuxins on To- 3208 In Viro Efficacy of a Novel Inhibitor of Selected Signal Transduction boisomerase II Cleavage in the Human c-myc Prolooncogene. Yves Pathways Including Calcium, Arachidonale, and Inositol Phosphates. 3250 Announcements Pommier, Ann Off, Kurt W. Kohn, and Jean-Francois Riou. Elise C. Kohn. Mary Ann Sandeen, and Lance A. Liotta. Eighty-Fourth Annual Meeting of the AACR AACR Special Conferences in Cancer Research 3131 Antibody Drug Carrier for Immtmotherapy of Superficial Bladder 3213 Platelet-derived Growth Factor and Its Receptors in Human Glioma Future Annual Meetings of the AACR Cancer: Ultrastructurul Studies. Etienne de Harvon, Yves Fradct, Tissue: Expression of Messenger RNA and Proteiu Suggests the Recent Death John G. Connolly, Wedad Hanna. Shaomu He, Yanchun Wang, Presence of Autocrine and Parucrine Loops. Monica Hermanson. Calendar of Events Bernard C, K. Choi, Roy McGroarty, George Bootsma, Aina Tilups, Keiko Funa. Magdalcna Hartman, Lena Claesson-Welsh, Carl- and Hilary Chrislensen. Henrik Heldin. Bengt Westcrmark, and Monica Nisl~r. 3253 Author Index

June 15, Number 12

3255 Selective in Firo Localization of Daunorubicin Small Unilamellar 3335 Growth Regulation of Human Renal Carcinoma Cells: Role of Truus- 3425 Interleukin 2 Acutely Induces Platelet and NentrophiI-Endothclial Vesicles in Solid Tumors. Eric A. Forssen, Dean M. Coulter, and forming Growth Factor a. lan Atlas, John Mendelsohn, Jose Baselga, Adherence and Macromolecular Leakage. Michael J. Edwards. Richard T. Proftht, William R. Fair, Hideo Masui, and Rakesh Kumar. Frederick N. Miller. David E. Sims, Deanna L. Abney, Dale A. Schuschke. and Tracey S. Corey. 3262 An Unmodified Anticarcinoma Antibody, BR96, Localizes to and 3340 Growth Inhibition by Cbolera Toxin of Human Luog Carcinoma Cell Inhibits the Outgrowtb of Human Tnmors in Nude Mice. George J. Lines: Correlation with G,, Gaoglioside Expression. Gurmeet Kaur, 3432 Dissociation of Sensitivities to Tumor Promotion and Progression in Schreiber, Karl Erik Hellstr0m, and lngegerd Hellstr0m. Jean Viallet. Jorgc Laborda. Owen Blair. Adi F. Gazdar, John D. Outbred and Inbred SENCAR Mice. I. B. Gimenez-Conti, A. B. Minna. and Edward A. Sausville. 3267 Effect of Thrombin Treatment of Tumor Cells on Adhesion of Tumor Bianchi, S. M. Fischer. J. J. Reiners, Jr,, C. J. Conti. and T. J. Slaga. Cells to Platelets in Vitro and Tumor Metastasis in Viro. Mary 3347 Activation of the Ha-, Ki-, and N-rus Genes in Chemically Induced Lynn R. Nierodzik, Francis Kajumo, and Simon Karpatkin. Liver Tumors from CD-I Mice. Sajata Manam, Richard D. Storer, 3436 Dose-Respoose Relationships for Chronic Exposure to 2,3,7,8-Te- Srinivasa Prahalada, Karen R. Leander, Andrew R. Kraynak, Brian tracholorndibcnzo-p-dioxin in a Rat Tumor Promotion Model: Quan- 3273 Placental Transfer of 4-(Methylnitrosamino)-l-(3-pyridyl)-I- J. Ledwith. Matthew J. van Zwieten, Mattbews O. Bradley, and tification and immunolocalization of CYPIAI and CYPIA2 in the butnnone Instilled Intzatrucheally in Syrian Golden Hamsters. Warren W. Nichols. Liver. Angelika M. Tritscher, Joyce A. Goldstein, Christopher J. Rossana Jorquera, Andre Castonguay, and Hildcgard M. Schuller. Portier, Zadock McCoy. George C. Clark, and George W. Lucier. 3353 Expression of Cytokine Genes, Cytokine Receptor Genes, and Tran- 3281 Expression of Gluathione Transferase ~r as a Predictor for Treatment scription Factors in Cultured Hodgkin and Reod-Sternberg Cells. 3443 Photofriu and Light Induces Microtubule Depolymerization in Cul- Results at Different Stages of Acute Nonlymphoblastic Leukemia. Hans-J0rgen Grass, Marion A. Brach, Hans-Gunter Drexlcr, Renate tured Human Endothelial Cells. Lee Ann Sporn and Thomas H. UIf Tidefelt, Annika Elmhorn-Rosenborg, Chrislcr Paul, Xiao-Yong Bonifer. Roland H. Mcrtclsmann. and Friedhelm Hcrrmann. Foster. Hao, Bengt Mannervik. and Lennart C. Eriksson. 3361 Induction of lnterleokin 2 Production but not Methiouine Adenosyl- 3449 Loss of Colonic HLA Antigens in Familial Adenomatuus Polypesis. 3286 Metabolism and Nucleic Acid Binding of N-Hydroxy-4-acetylami- transferase Activity or S-Adenosylmcthionine Turnover in Jurkat T- George Tsioulias. Thomas A. Godwin, Marjorie F. Goldstein, Carl nobiphenyl nnd N-Acetoxy-,4-acetylamiuobiphenyl by Cultured Hu- Cells. James De La Rosa. Arthur M. Gcller, H. Leighton LeGros, J. McDougall. Ngoi Sing-Shang, Jerome J. DeCosse, and Basil Rigas. man Urocpitheliai Cells. Santhanam Swaminathan and Catherine A. Jr., and Malak Kotb. Reznikoff. 3453 Expression of c-sis/Platelet-derived Growth Factor B, Insulin-like 3367 K-sam-related Gene, N-sam, Encodes Fibroblost Growth Factor Re- Growth Factor I, and Transforming Growth Factor a Messenger 3295 Overexpeession of Cholecystokiniu Receptors in Azaserine-indneed ceptor and Is Expressed in T-Lymphocytic Tumors. Yulaka Hattori, RNAs and Their Respective Receptor Messenger RNAs in Primary Neoplasms of the Rat Pancreas. Richard H. Bell, Jr., Elna T. Hiroki Odagiri, Osamu Katoh. Hiromi Sakamoto, Toshirou Morita, Human Gastric Carcinomas: In Viro Studies with in Situ Hybridi- Kuhlmann. Robert T. Jensen, and Daniel S. Longneckcr, Kunitada Shimotohno. Kensei Tobinai, Takashi Sugimum. and zation and Immnnocytochemistry. Cha K. Chang and Harry' N. Masaaki Terada. Antoniades. 3300 Activation of a B-Hydroxyalkylnitrosamine to Alkylating Agents: Evidence for the Involvement of a Sulfotransferuse. Marilyn B. 3372 Genes Preferentially Expressed in Embryo Stomach Are Predomi- 3460 Expression of Class II Major Histocompatibility Complex Molecules Kroegcr-Koepke, Steven g. Koepke, Lidia Hernandcz, and nantly Expressed in Gastric Cancer. Masamitsu Tanaka, Hiroki Correlates with Human Colon Tumor Vaccine Efficacy. Janet H. Christopher J. Michejda. Sasaki. Isamu KinD, Takashi Sugimura, and Masaaki Terada. Ransom. Barbara Pelle, and Michael G. Hanna, Jr. 3306 Flavone Acetic Acid Increases the Antitumor Effect of Hyperlhermla 3378 Transcriptional Regulation of the Human Placental-like Alkaline Phosphatase Gone and Mechanisms Involved in Its Induction by 3467 Differential Immunobistochemical Detection of Amphiregulin and in Mice. Yoshihisa Sakaguchi. Yoshihiko Maehara, Hideo Baba, Cripto in Iluman Normal Colon and Colorectul Tumors. Toshiaki Tetsuya Kusumoto, Keizo Sugimachi. and Robert A. Newman. Sodium Butyrate. GuDrun Dung, Guohui Liu, Lisheng Hu, James R. Gum, Jr., and Young S. Kim. Saeki, Kurl Stromberg, Chen-Fcng Qi, William J. Gullick, Eiichi Tahara, Nicola Normanno. Forlunato Ciardiello. Nicholas Kcnne~.,, 3310 Generation of a Sman Cell Lung Cancer Variant Resistant tu Lyre. 3384 Teniposide Induces Nuclear but not Mitochondrial DNA Degrada- Gibbes R. Johnson. and David S. Salomon. phokine-aetivated Killer (LAK) Cells: Association with Resistance to tion. Clifford G. Topper and George P. Studzinski. a LAK Cell-derived, Cytostatic Factor. Isao Tachibana. Masatoshi Watanabe, Yoshiro Tanio, Seiji Hayashi, Shigeto Hosoe. Shin'ichi 3391 Evidence for a 17p Tumor Related Locus Distinct from p53 in Saito. Machiko Matsunashi. Tadashl Osaki, Yoshihisa Shigedo, Podiatric Primitive Nenroectodermal Tumors. Jaclyn A. Biegel, Carol Tomiya Masuno, and Ichiro Kawase. D. Burk, Frederic G. Barr, and Beverly S. Emanuel. 3317 Serum Level of Interleukin 6 us a Prognosis Factor in Metastatic 3396 Distribution of the Folate Receptor GP38 in Normal and Malignant Renal Cell Carcinoma. Jean-Yves Blay, Sylvie Negrier, Valerie Cell Lines and Tissues. Steven D. Weitman, Richard H. Lark, Leslie ADVANCES IN BRIEF Combaret, Stephane Atlali, Evelyne Goillot. Yacine Merrouche, R. Coney, Daniel W. Fort, Verna Frasca, Vincent R. Zarawski, Jr., Alain Mercatello, Alain Ravauh, Jean-Marc Tourani, Jean-Francois and Barton A. Kamen. 3474 Deletion of Chromosome 17p Loci in Breast Caneer Cells Detected Moskovtchenko, Tbierry Philip, and Marie Favrot. by Fluorescence in Situ Hybridization. K. Matsumara, A. 3402 Rapid Tumor Penetration of a Single Chain Fv and Comparison with Kallioniemi, O. Kallioniemi, L. Chcn, H. S. Smith, O. Pinkel, J. Other immunoglobuliu Forms. Takashi Yokota, Diane E. Milenic, 3323 Estimation of Prostatic Growth Using Serial Prostate-specific Anti- Gray. and F. M. Waldman. gen Measurements in Men with and without Prostate Disease. H. Marc Whitlow, and Jeffrey Schlom. Ballentine Carter, Christopher H. Morrell, Jay D, Pearson, LarD, J. 3409 Resistance to N-Benzyladrlamycin-14-valerate in Mouse J774.2 3478 Neoplastic Transformation of Immortalized tluman Keratinocytes Brant, Constantine C. Plato, E. Jeffrey Melter, Daniel W. Chan, Cells: P-Glyeoprotein Expression without Reduced N-Beozylndria- by 2,3,7,8-Tetrachlorodibeuzo-p-dioxiu. Jae-Ho Yang. Peter Thra~es. James L. Fozard, and Patrick C. Walsh. mycin-14-valerate Accumulation. Leonard Lothstein. Trevor W. Anatoly Dritschilo. and Johng S. Rhim, Sweatman, Michael E. Dockter, and Mervyn Israel. 3329 Indnction of Retinoic Acid-binding Proteiu in Normal and Malignant 3483 c-Ha-ras Containing 8-Hydroxyguanine at Codou 12 Induces Point Human Myeloid Cells by Retinoic Acid in Acute Promyelocytic 3418 Programmed Cell Death in an Estrogen-independent Human Breast Mutations at the Modified and Adjacent Positions. Hiroyuki Leukemia Patients. Monique Cornic. Laurent Delva, Fabien Guidez, Cancer Cell Line, MDA-MB-.468. Deborah K, Armstrong, John T. Kamiya. Kazunobu Miura, Hiroyuki lshikawa, Hideo InDue. Nicole Balitrand, Laurent Degos, and Christine Chomienne. Isaacs. Yvonne L. Oltaviano. and Nancy E. Davidson. Susumu Nishimura, and Eiko Ohtsuka.

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3486 Localization of Metastasis Suppressor Gene(s) for Prostatic Cancer 3498 Recombinant Human Stem Cell Factor Stimulates Growth of a 3510 Announcements to the Short Arm of Human Chromosome 11. Tomohiko Ichikawa. Human Gliobiastoma Cell Line Expressing c.kit Protooncogene. Eighty-Fourth Annual Meeting of the AACR Yayoi Ichikawa, Jintang Don?,, Anita L. Hawkins, Constance A. Wolfgang E, Berdel, Sven de Vos, Juergen Maurer, Dorothea AACR Special Conferences in Cancer Research Griffin, William B. Isaacs, Mitsuo Oshimura, J. Carl Barrett, and Oberberg, Zofia yon Marschall. Jan K. Schrocder. JUan Li, Wolf- Future Annual Meetings of the AACR John T. Isaacs. Dieter Ludwig, Ernsl D. K-,'euser, Eckhard Thiel, and Friedbelm Calendar of Events Hen'mann. 3491 CellCycle-related Expression of p120 Nucleolar Antigen in Normal 3503 Modulation of the Cytotoxic Effect of Cyelopentenykytosine by Its Human Lymphocytes and in Ceils of HL-60 and MOLT-4 Leukemic Primary Metabolitr Cyelopentenyluridinr Susan M. Blaney, Frank 3512 Errata Lines: Effects of Methotrexate, Camptothecin, and Teniposide. M. Balis, Jean Greta, Diane E. Cole, Peter C. Adamson, and David T. G. Cotter et al., 52: 997-1005, 1992. Wojciech Gorczyea, Silvia Bruno, Myron R. Melamed, and Zbigniew G, Poplack. G. Y. Kwei et al., 52: i639-1642, 1992. Dar-zynkiewicz. B. Fisher. 52:237 i-2383, 1992. 3506 Molecular Analysis of the Protein Tyrusine Phosphatase "y Gene in Human Lung Canter Cell Lines. Tetsuya Tsokamoto, Takashi 3495 Taxol Sensitizes Human Astrocytoma Cells to Radiation. Roy B. Takahashi, Ryuzo Ueda. Keoji Hibi, Haruo Saito. and Toshitada Tishler, Charles R. Geard, Eric J. Hall, and Peter B. Schiff. Takahashi. 3513 Author Index

July 1, Number 13

3515 Modulation of the Call Cycle-dependent Cytotoxicity of Adriamyein 3636 Inhibition of Breast Cancer Cell Growth in Vitro by a Tyrosine 3760 Oncogene Complementation in Fetal Brain Transplants. Otmar D. and 4-Hydroperoxyeyclophosphamideby Novobiocia,an Inhibitor of Kinase Inhibitor. Kaladhar B. Ruddy, Gina L. Mangold, Atul K, Wicstler, Adriano Aguzzi, Markus Schneemann, Robert Eib[, Mammalian Toooisomerase II. Francis Y. F. Lee, Deborah J. Tandon. Toshiyuki Yoneda, Gregory R. Mundy. Asher Zilbe~tein. Andreas yon Deimling, and Paul Kleihues. Flannory, and Dietmar W. Siemann. and C. Kent Osborne. 3768 lmmnaobistochemieal Identification of P-Glyeoprotein in Previously 3521 Inbibitian of Dlhydroorotate Dehydrogenase Activity by Bteqidnar 3642 New Apprateh for Datection of Amplification in Cancer DNA Using Untreated, Diffuse Large Cell and Immunobiastic Lymphomas. Sodium. Shih-Fnng Chen, Frank W. Perrella, Davette L. Behrens, Restriction Landmark Genomie Scanning. Shinji Hirotsune, Izuho Gloria A. Niehans, Waclaw Jaszcz, Virginia Brunetto, Robert T. and Lisa M. Papp. Hatada, Hideyuki Komatsubara, Hisaki Nagai, Kanji Kuma, Kiyoshi Peril, Kazimiera Gajl-Peczalska, Mark R. Wick, Takashi Tsuruo, Kobayakawa, Tsutomu Kawara, Akira Nakagawara. Kiyotaka Fnjii, and Clara D. Bloomfield. 3528 Inhibition of Mmine Tumor Growth by an Interferon-inducing Imi- Tsunehiro Mukai, and Yoshihide Hayashizaki. dazoqubiolinamino. Younan A. Sidky, Ernest C. Borden, Charles E. Weeks, Michael J. Reiter, James F. Hatcher, and George T. Bryan. 3648 Response of Human Breast Cancer Cells to Heat Shock and Chem- otherapeutic Drugs. Daniel R. Ciocca, Suzanne A. W. Fuqua, Sarah 3534 Antitumor Activity of Magnlnin Analogues against Human Lung Lock-Lira, David O. Toil, William J. Welch, and William L. Cancer Cell Lines. Yoshinobu Ohsaki, Adi F. Gazdar, Hao-Chia McGuire, ADVANCES IN BRIEF Chen, and Bruce E. Johnson. 3655 Effect of a Dihydropyridine Analague, 2-1Benzyl(phenyl)aminolethyl 3776 Taxol Blocks Processes Essential for Prostate Tumor Cell (PC-3 3539 Uptake of the Noneytatoxic Transport Probe Preeainamtde in the i ,4-Dihydro-2,6-dimethyl-5-(5,5-dimet hyl- 2-oxo- 1,3,2--dioxaphos- ML) Invasion and Metastases. Mark E. Stearns and Min Wang, Chinese Humster Ovary Model of Multidrog Resistance. K. V. phorinan-2-yl-I -( 2-morpholinoet hyl)-4-(3-nitrophenyl)-3- pyridine- 3782 UDP-N-Acetylhexosamine Modulation by Glncosamine and Uridine Speog, Jr., Catherine deLeon, and William L. MeGuire. earbexyiate, on Reversing in Viro Resistance of Tumor Cells to in NCI N-417 Variant Small Cell Lung Cancer Cells: 3tp Nuclear 3547 Metabolism of N-Nitrosomnthyl-n-amylamineby Microsomes from Adriamyein. Kiyoshi Niwa, Kazutaka Yamada, Tatsuhiko Magnetic Resonance Results. Nathanael V. Pederson, Richard H. Human and Rat Esophagus. Qin Huang, Gary Stoner, James Resau, Furukawa. Norimasa Shudo, Kiyotomo Scan, Tamotso Matsumoto, Knop. and William M. Miller. Jeanctta Nickols, and Sidney S. Mirvish. Sonshin Takao. Shin-ichi Akiyama, and Hisaaki Shimazu. 3787 Human lmmnnodeficiency Virus Type I tat Gene Up-regulates In- terlcokin 4 Receptors on n Human B-Lymphobiastoid Cell Line. Raj 3552 Changes in Rectal Epithelial Cell Proliferation and Intestinal Bile 3661 Mecrophage Colony-stimulating Factor (CSF-I) Enhances Invasive- K. Puri and Bharat B. Aggarwal. Acids after Subtotal Colectomy in Familial Adenomatans Polyposis. ness in CSF-I Receptor-positive Carcinoma Cell Lines. Andrew E. Annemieke Cats, Jan H. Kleibeuker, Folkert Kuipers, Machiel J. Filderman, Andrew Bruckner. Barry M. Kacinski. Nanhua Dung. 3791 p53 Mutations in C57BL/6J Marine Thymic Lymphomas Induced Hardonk, Ren~ C. J. Verschueren, Wytske Baersma, Roel J. Vonk, and Heinz G. Remold. by 3'-Irradiation and N-Methylnitrosourea. Ormond Brathwaite. William Bayona, and Elizabeth W. Newcomb. Wire J. Sluiter, Nanno H. Mulder, Bert G. Wolthers, and Elisabeth 3667 Expression of Human hsp70 in Rat Fibrobiasts Enhances Cell Sur- G. E. de Vries. vivaland Facilitates Recoveryfrom Translational nnd Transcriptional 3796 Stimulation of Malignant Growth in Rodents by Antidepressant Drags at Clinically Relevant Doses. Loroe J. Brandes, Randi J, 3558 Multiple Biological Markers in Germ Cell Tumor Patients Treated Inhibition following Heat Shock. Richard Y. Liu. Xiaochuan Li, Arron, R. Patricia Bogdanovic. Jiangang Tong, Cheryl L. F. with Piatinum-bnsod Chemotherapy, Frederica P. Perera, Robert J. Ligeng Li, and Gloria C. Li. Zaborniak, Georgina R. Hogg. Robert C. Warrington, Wei Fang, Motzer, Deliang Tang, Eddic Reed, Riccardo Parker, Dorothy and Frank S. LaBella. Warburton, Patrick O'Neill, Richard Albertini, William L. Bigbee, 3674 Mutation Pattern of the p53 Gene as a Diagnostic Marker for Ronald H. Jensen, Regina Santella, Wei-Yann Tsai, Gabriella Multiple Hepntocellular Carcinoma. Tatsuya Oda. Hitoshi Tsuda. 3801 Lossof Expression of the DCC Gene during Progression of Colorec- Simon-Cereijido, Colleen Randall, and George Bosl. Aldo Scarpa. Michiie Sakamoto. and Sctsuo Hirohashi. tal Carcinomas in Familial AdenomatousPolyposis and Non-Familial Adenomatoos Polyposis Patients. Rei K,ikuchi-Yanoshita. Motoko 3566 Synorgism between Dipyridamole and Cispiatin in Human Ovarian 3679 Interleukin 6 Gene Transfection into Lewis Lung Carcinoma Tumor Konishi. Hiroyuki Fukunari, Kiyoko Tanaka, and Michiko Miyaki. Cells Suppresses the Malignant Phenotype and Confers Immano- Carcinoma Cells in Vitro. Antti Jekunen, Jeffery Vick, Raghuram 3804 p53 Mutations in Basal Cell Carcinomas. Peter Rady, Franco therapeutic Competence against Parental Metastatic Cells. Angel Sanga, Thomas C. K. Chart, and Stephen B. Howell. Scinicariello, Richard F. Wagner, Jr., and Stephen K. Tyring. Porgador, Esther Tzehoval, Anne Katz. Ezra Vadai. Michel Revel, 3572 Adriamycin-inducodModulation of Host Defenses in Tumne-bearin8 Michael Feldman, and Lea Eisenbach. 3807 Partial Characterization of Nuclear Matrix Attachment Regions from Mien. Darbie L. Maccubbin, Kathleen g. Wing, Kenneth F, Mace, Human Fibrobiast DNA Using Alu-Polymerase Chain Reaction. Richard L. X. Ho, M. Jane Ehrkc, and Enrico Mihich. 3687 Characterization of the PML-RARo Chimeric Product of the Acuw Gregory J. Tsongalis, William B. Coleman, Gary J. Smith, and David Promyelocytie Leukemia-specific t(15;17) Translocntina. Clara G. Kaufman. 3577 Acrolein Initiates Rat Urinary Bladder Carcinogenesis. Samuel M~ Nervi, E, Christine Poindexter, Francesco Gngnani, Pier Paolo 3811 An Altered I I-Kilobose Transcript in Leukemic Cell Lines with the Cohen, Emily M. Garland, Margaret St. John, Takehiko Okamura, Pandolfi, Francesco Lo Coco, Giuseppe Avvisati. Pier Giuseppe l(4;llXq21;q23) Chromosome Translocation. G. Cimino. T. and Raymond A. Smith. Pelicci, and Anton M. Jetten. Nakamura, Y. Gu. O. Canaani, R. Prasad, W. M. CrUst. A. J. Carroll. 3582 Inhibition of Skin Tumor Promoter-caused Induction of Epidermal M. Baer, C. D. Bloomfield. P. C. NowelL C. M. Croce, and E Ornithino Decarbexylaee in SENCAR Mice by Polypbenolic Frac- 3693 Oxidation of Methylhydrazines to Mutagnnir Methylating Deriva- Canaani. tives and Inducers of the Adaptive Response of Esckeriehia coil to tion Isolated from Green Tea and its Individual Epieatechin Deriva- 3814 Gadd 45 and Gadd 153 Messenger RNA Levels Are Increased during Alkylation Damage. Barbara Scdgwick. tives. Rajesh Agarwal, Santosh K. Katiyar, Syed 1. A. Zaidi, and Hypoxia and after Exposure of Cells to Agents Which Elevate the Hasan Mukhtar. 3698 The Potential Superiority of Bromodeoxyuridinoto lododeoxyuridine Levels of the Glueose-regalated Proteins. Brendan D. Price and Stuart K. Calderwood. 3589 Meal Frequency and Risk of Colornctal Cancer. Silvia Franceschi, as a Radiation Sensitizer in the Treatment of Colorectnl Cancer. Carlo La Vecchia, Ettore Bidoli, Eva Negri, and genato Talamini. Theodore S. Lawrence, Mary A. Davis. Jonathan Maybaum. Sunil K. Mukhopadhyay. Philip L. Stetson, Daniel P. Normolle. Paul E. 3593 Interaction of Antileukemia Agents Adriamycin and Daunomycin McKcever. and William D. Ensminger. with Sphinlpmino on the Differentiation of Human Leukemia Cell Line HL-60. Benjamin Y-M. Yung, K. J. Luo, and Erie K-W. Hui, 3705 Responsiveness of Three Newly Established Human Colorectal Can- LE'VI'ER TO THE EDITOR cer Cell Lines to Transforming Growth Factors ~ and B2. L. Suardet. 3818 Correspondence re: L. E. Damon et aL, Plasma and Cerebrospinal 3598 Inhibition of Hepntocyte DNA Synthesis by Transforming Growth A-C. Gaide, J M. Calms, B. Sordat, J-C. Givel, J F, Eliason, and Fluid Pharmacokinctics of l-B-t>-Arabinofuranosylcytosineand I-B- Factor fl~ and Cyclic AMP:. Effect Immediately before the GdS N. Odartchenko, o-Arabinofuranosyluraeil following the Repeated Intravenous Ad- Border. G. Huge Thoresen, Magne Refsnes. and Thoralf ministration of High- and Intermediate-Dose I-B-o-Arabinofurano- Christoffersen. 3713 Differentiation of Chorioearcinoma Cell Line (JAr). Abraham sylcytosine. Cancer Res., 51: 4141-4145, 1991. Wi[li Kreis and Hochberg, Jacob Rachmilewitz. Talia Eldar-Geva. Tamar Salant. Daniel R. Budman. Reply by Lloyd E. Damon~ William Plunkett. 3604 i,Histidinol: Preclinieal Therapeutic Studies in Combination with Tamar Schneider, and Nathan de Groot. Antitumor Agents and Pharmacokinotic Studies in Mice. Daniel and Charles A. Linker. Zaharko, Jacqueline Plowman, William Wand, Donald Dykes, and 3718 Differentiation of HT-29 Human Colonic Adenocarcinoma Cells Louis Malspeis. Correlates with Increased Expression of Mitochondrial RNA: Effects of Trehalose on Cell Growth and Maturation. Xiang Lu. Teena 3610 Inhibition of in Vitro Ovarian Cancer Cell Invasion by Modulation Walker, John P. MacManus, and Verner L. Selig}. of Urokinase-tyl~ Plasmiuognn Activntor und Catbepsin B. Hiroshi MEETING REPORT Kobayashi. Hidekazu Ohi, Motoi Sugimura, Hiromitsu Shinohara, 3726 Gnstrin-releasiog Pcptide: In Vivo and in Vitro Growth Effects on 3821 Fourth Charles Heidelberger Conference on Transformation and Toshiro Fujii. and Toshihiko Terao. an Acinnr Pancreatic Carcinoma. Amor Hajri, Ginette Balboni. Chemotherapy. Peter A. Jones. Mich~lc Kocnig, Jean-Claude Garaud. and Christiane Damon. 3615 2-Amino-3,4-dimethylimidazo{4,5-J]quinolineIndue'us and Inhibits Cytochrome P450 from the IA Subfamily in Chick and Rat Hepato- 3733 Evaluation of the wap-rm Transgenic Mouse as a Model System for cyrus. Jacqucline F. Sinclair, Barbara K. Schaeffer, Sheryl G. Wood, Testing Antieancer Drugs. Loretta L. Nielsen. Maya Gurnani, and Linda K. Lambrecht. Nadia Gorman. W. Jay Bament. E. Lucile Ronald D. Tyler. Smith, Peter R. Sinclair, and Charles A. Waldren. 3826 Announcements 3739 Specificityand ImmanobiologiealProperties of Monoclonal Antibody Eighty-Fourth Annual Meeting of the AACR 3622 Characterization and Purification of n Guanidinobenzontase: A Pos- IMH2, Established after Immunization with Le"/Le" Glycosphingo- AACR Special Conferences in Cancer Research sible Markor of Human Renal Carcinoma. Claudine Poustis-Delpont. lipid, a Novel Extended Type I Chain Antigen. Hisashi Inn. Kazuhiro Recent Death Roland Descomps, Patrick Auberger, Pascale Delqne-Bayer, Pierre Tashiro, Mark R, Slroud, Torben F. ~rntoil, Peter Meldgaard, Anil Calendar of Events Sudaka, and Bernard Rossi. K. Singhal, and Scn-itiroh Hakomori. 3629 Low-Dansity Lipoprotein for Delivery of an AcrylophenoneAntiueo- 3828 Erratum 3746 SAS Amplification in Soft Tissue Sarcomas, Sharon H Smith, D. K. Manchester et al., 52: 1499-1503, 1992. plastic Molecule into Malignant Cells. Sophie Lestavel-Delattre, Sharon W. Weiss, Sheryl A. Jankowski, Marco A. Coccia, and Paul Francoise Martin-Nizard, V~ronique Clayey, Pierre Testard, GUiles S. Meltzer. Favre, Goulven Doualin, Hayat Sqalli Houssaini, Jean-Marie Bard, 3828 Retraction Patrick Duriez, Christiane Delbart, Georges Soula. Daniel Lesieur, 3750 Elevated Level of Nuclear Protein Kinase C in Multidrug-reslstant T. Nitta et al,, 51, 5565-5569, 1991. lsabelle Lesieur, Jean-Claude Cazin, Michcline Cazin, and Jean- MCF-7 Human Breast Carcinoma Cells. Sung Ae Lee. James W. Charles Fruchart. Karaszkiewicz,and Wayne B. Anderson. 3829 Author Index

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July 15, Number 14

3831 Distribution of Misonidazole Adducts in 9L Gliosarcoma Tumors 3918 p53 Mutations Occur in Aggressive Breast Cancer. Raoul Mazars, 4017 Herbimycin A, an Inhibitur of Tyrosine Kinase, Prolongs Survival of and Spheroids: Implications for Oxygen Distribution. Allan J. Laura Spinardi, Meryem BenCheikh. Joellc Simony-Lafontaine, Mice Inoculated with Myeloid Leukemia CI Cells with High Expres- Franko, Cameron J. Koch, and Don P. J. Boisvert. Philippe Jeantcur, and Charles Theillet. sion of v-abl Tyrosine Kinase. Yoshio Honma, Juoko Okabe-Kado, Takashi Kasukabe, Motoo Hozumi, Hiroaki Kodama, Sachiko 3838 Long-Term Growth Suppression of Human Glioma Xenografts by 3924 Insulin Receptor Expression and Function in Human Breast Cancer Kajigaya, Toshio Suda, and Yoshisada Miura. Chemoimmunocanjngates of 4-Desacetylvinhlastine-3-carboxyhy- Cell Lines. Giovanni Milazzo, Francesco Giorgino, Giuseppe Da- drazide and Monocinnal Antibody 9.2.27. Martin Schrappe, Thomas mante, Chin Sung, Martha R. Stampfer, Riccardo Vigneri, Ira D. 4021 Limoneno-induced Regression of Mammary Carcinomas. Jill D. F. Bumol, Lynn D. Apelgrcn, Stephen L. Briggs, Gary A. Koppel, Goldfine, and Antonino Belfiore. Hang, Mary J. Lindstrom, and Michael N. Gould. Dorothy D. Markowitz, Barbara M. Muellcr, and Ralph A. Reisfeld. 4027 Differenliation-induced Changes in Protein-Tyrosine Phosphatase 3931 Genetic Modifieatmn of a Murine Fibrosarcoma to Produce Interleu- Activity and Commensurate Expression of CD45 in Human Leuke- 3845 Effect of Systemic Hyperinsuliocmia in Cancer Patients. Martin J. kin 7 Stimulates Host Cell Infiltration and Tumor Immunity. William mia Cell Lines. Marina Buzzi, Li Lu, Anthony J. Lombardi, Jr., Heslin. Elliot Newman, Ronald F. Wolf, Peter W. T. Pasters, and H. McBride, J, Dean Thacker, Sian Comora, James S, Economou, Marshall R. Posner, David L. Brautigan, Lauren D. Fast, and A. Murray F. Brennan. David Kelley, Donna Hogge, Stereo M. Dubinett, and Graeme J. Raymond Frackelton, Ir. Dougherty. 3851 Modulation of Ethylnitrosourea-induced Toxicity and Mutagenicity 4036 Expression of a Traosfected H-21f ~ Gene in Bi6 Cells Correlates in Human Cells by O%Benzylguanine. S. Maynard Bronstein, 3938 Retinoid Antagonism of Estrogen-responsive Transforming Growth with Suppression of Liver Metastases in Triple Immunodeficient Michelle J. Hooth, James A. Swenberg` and Thomas R, Skopek. Factor a and pS2 Gene Expression in Breast Carcinoma Cells. Joseph Mice. Lido Calorini, Anna Marozzi, H. Randolph Byers, Gerald L A. Fonlana, Clara Nervi, Zhi-Ming Shao, and Anton M. Jctten. Waneck, Kenneth W. Lee, Kurt J. lsselbacher, and Sebastiano 3857 Mechanism-related Circumvention of Acquired cls-Diamminedi- Gattoni-Celli. chloro Resistance Using Two Pairs of Human Ovarian Carcinoma 3946 N-eas Mutation in Ultraviolet Radiation-induced Murine Skin Can- Cell Lines by Ammine/Amine Platiannl(IV) Dicarboxyinles. Lloyd cers. William E. Pierceall, Margaret L. Kripkc. and Honnavara N. R. Kelland, Prakash Mistry, George Abel, Swee Y. Loh, Ciaran F. Ananthaswamy. O'Neill, Barry A. Murrer, and Kenneth R. Harrap. ADVANCES IN BRIEF 3952 Mechanism of c-los Induction by Active Oxygen. Paul A, Amstad, 4042 Transforming Growth Factor Bi Induces Apoptotic Cell Death in 3865 Relation of Obesity and Body Fat Distribution tu Endometrial Cancer Georg Krupitza, and Peler A. Cerutti. Cultured Human Gastric Carcinoma Cells. Kazuyoshi Vanagihara in Shanghai, China. Xiao Ou Shu, Louise A. Brinton, Wen Zheng` and Masaru Tsumuraya. Christine A. SwanSOn, Maureen C. Hatch, Yu-Tang Gao, and Joseph 3961 Salmonella typMmurium Strains Expressing Human Aryinmine N- F. Fraumeni, Jr. Acetyltransferases: Metabolism and Mutagenic Activation of Aro- 4046 Abundant Expression of lmmunoreactive Endothelin I in Mammary matic Amines. Denis M. Grant, P. David Josephy, Heather L. Lord, Phyllodes Tumor: Possible Poracrine Role of Endothelin I in the 3871 Phase II Study of Intravenous ldarabicin in Unfavorable Non-Hodg- and Lesley D. Morrison. Growth of Stromal Cells in Phyllodes Tumor. Jun-ichi Yamashita, kin's Lymphoma. Dr C. Case, Jr., Miriam C, Gerber, Richard Michio Ogawa, Hiroshi Egami, Shuichi Matsuo, Hideo Kiyohara, A. Gums, Jeffrey Crawford, May U Votaw, Celestia S. Higano. Brian 3965 Genotic Cbanges of Both p53 Alleles Assuciated with the Conversion Kazuo Inada, Shin-ichi Yamashita, and Syoji Fujita. T. Pruitt, and James Gould. from Coloractal Adenoma to Early Carcinoma in Familial Adeno- matuos Polyposis and Nan-Familial Adenomatous Polyposis Pa- 4050 Enhancement of Antioxidant and Phase II Enzymes by Oral Feeding 3875 Inhibition of Tobacco-specific Nitrosamine-induced Lung Tumori- tients. Rei Kikuchi-Yanoshita. Motoko Konishi, Satomi Ito, Madoka of Green Teu Polyphenols in Drinking Water to SKH-I Itairiess genesis in A/J Mice by Green Tea and Its Major Polyphenol as Scki, Kiyoko Tanaka, Yoshiharu Maeda. Hiroshi lino, Masashi Mice: Possible Role in Cancer Chemoprevention. Sikandar G. Khan, Antioxidants. Yong Xu, Chi-Tang Ho, Shantu G. Amin, Chi Han, Fukayama, Morio Koike, Takeo Mori, Hitoshi Sakuraba, Hiroyuki Santosh K. Katiyar, Rajesh AgarwaL and Hasan Mukhtar. and Fung-Lung Chung. Fukunari, Takeo Iwama, and Michiko Miyaki, 4053 3-Aminohenzamide Can Act as a Cocarcinogen for Ultraviolet Light- 3880 Tumoricidal Activation of Murino Resident Peritoneal Macrnphages induced Carcinogenesis in Mouse Skin. John H. Epstein and James 3972 Distribution of the Glucose Transporters in Human Brain Tumors. E. Cleaver. by Interleukin 2 and Tumor Necrosis Factor a. Srdan Verstovsek, Tatsuya Nishioka, Yoshifumi Ode, Yutaka Scino, Taizo Yamamoto, Darbie Maccubbin, M. Jane Ehrke, and Enrico Mihich. Nobuya Inagaki, Hideki Yano, Hiroo lmara, Ryuichi Shigcmoto, 4055 Correlation between the Location of Germ-Line Mutations in the and Haruhiko Kikuchi. APC Gene and the Number of Colorectal Polyps in Familial Ade- 3886 l-B-D-Arabinofuranosylcytosioc-diphosphate-choline Is Formed by nomatuus Polyposis Patients. Hiroki Nagase, Yasuo Miyoshi, Akira the Reversal of Cholinephosphotransferase and not via Cytidylyl- 3980 Complete Inhibition of Growth followed by Death of Human Malig- Horii, Takahisa Aoki, Michio Ogawa, Joji Utsunomiya. Shozo Babe, tzansferase. Gregory L. Kucera and Robert U Capizzi. nant Melanoma Cells in Vitro and Regression of Human Melanoma Takehiko Sasazuki. and Yusuke Nakamura. 3892 Identification of Novel Antimitotic Agents Acting at the Tabulin Xenografts in lmmunodeficient Mice hy Cumptuthecins. Panayotis Level by Computer-essisted Evaluation of Differential Cytotoxicity Pantazis, Hellmuth R. HinL John T. Mendoza, A. J. Kozielski, Leo Data. Kenneth D. Paull, Chin M. Lin, Louis Malspeis, and Ernest J. Williams, Jr., John S, Stehlin, Jr., and Beppino C. GiovanelIa. MEETING REPORT Hamel. 3988 Loealization of Tumors and Evaluation of Their State of Oxygenation 4058 Workshop Report from the Division of Research Grants, National hy Phosphorescence Imaging. David F. Wilson and George J. 3901 Free Human Chorionic Gonadotropin // Subunit in Gonadal and Institutes of Health: Metal Carcinogenesis--A Chemical Pathology Cerniglia. Nongonadal Neoplasms. lsabelle Marcillac, Frrd~ric Troalen, Jean- Study Section Workshop. Karen E. Wetterhahn. Bruce Demple, Michel Bidart, Pascale Ghillani, Vincent Ribrag, Bernard Escudier. Molly Kulesz-Martin, and Edmund S. Copeland. Benoit Malassagne, Jean-Pierre Droz, Catherine Lhommr, Philippe 3994 Growth Inhibition of Human Glioma Cells Induced by 8-Chloroaden- Rougier. Pierre Duvillard, Michel Prade, Pierre-Marie Lugagne, esioe, an Active Metabolite of 8-Chloro Cyclic Adenosine 3':5'- Francois Richard, Thierry Poynard, Claude Bohuon, Jack Wands, Monophesphate. Cornelia H. Langcveld, Cornelia A. M. Jongcnelen. and Dominique BeUet. Jan J. Heimans. and Johannes C. Stoof, 4064 Announcements Eighty-Fourth Annual Meeting of the AACR 3908 Intrinsic Resistance to Metbotrexate in Human Soft Tissue Sarcoma 4000 Subeelluinr Distribution of the Anticancer Drug Mitoxautrone in AACR Special Conferences in Cancer Research Cell Lines. Wen-Wen Li, James T. Lin, Barry. I. Schweitzer, William Human and Drag-resistant Morine Cells Analyzed hy Flow Cytom- Recent Death P. Tong. Donna Niedzwiecki. and Joseph R. Bertino, etry and Confecal Microscopy and Its Relationship to the Induction Calendar of Events of DNA Damage. Paul J. Smith, Hazel R, Sykes, Mary. E. Fox. and 3914 Correlation of Loss of Alleles on the Short Arms of Chromosomes Isle J. Furlong. 11 and 17 with Metastasis of Primary Breast Cancer to Lymph 4066 Erratum Nodes. Ken-ichi Takita, Takaaki Sato, Mutsuko Miyagi, Masahiro 4009 HLA Class II Antigen Expression in 1lumen Papillomavirus-asso- C. R. Boland er el. 51. 657-665. 199 I, WatatanL Futoshi Akiyama, Goi Sakamoto, Fujio Kasumi, Rikiya elated Cervical Cancer, Susan S. GIcw, Margaret Duggan-Keen. Abe, and Yusukc Nakamura. Teresa Cabrera. and Peter L. Stern. 4067 Author Index

August I, Number 15

4069 Azidothymidin~iodnead Cytotoxicity and Incorporation into DNA in 4117 Tumor Resistance Induced by Syngeneic Bone Marrow Transplan- 4175 Identification and Characterization of New Antigenic Fragments the Human Colon Tumor Cell Line HCT-8 Is Enhanced by Melho- tation and Enham'ed by Interlankin 2: A Model for the Graft versus Related to Carcinoembryonic Antigen in Adult Feces. Jerry G. trexate in Vitro and in Viva. Patrizia Tosi, Paul Calabresi, Frederick Leukemia Reaction. Larry W. Kwak, Michael J, Campbell, and Henslee, Edward J. Vachula, Raymond J, Paxton, Matthew S. A. Goulette, Cynthia A. Renaud, and James W. Daruowski. Ronald Levy. Matias, John E. Shively, Harry G. Rittenhouse, and Joseph T. Tomita. 4074 Biochemical Modulation of Tumor Cell Energy:. Regression of 4121 Structure-Activity Study and Design of MuBidrug-resistunt Reversal Advanced Spontaneous Murino Breast Tumors with a 5-Fluoruuracil- Compounds by a Computer Automated Structure Evaluation Meth- 4183 Gene- and Strand-specific Damage and Repair in Chinese Hamster containingDrug Combination. Robert L. Stolfi. Joseph R. Colofiore. odology. Gilles Klopman, Sanjay Srivastava, Istvao Kolossvary, Ovary Cells Treated with 4-Nitroquinoline l-Oxide. Elizabeth G. L. D. Nord, Jason A. Koutcher. and Daniel S. Martin. Raquel F. Epand, Nadeem Ahmed, and Richard M. Epand. Snyderwine and Vilhelm A. Bohr. 4082 Prevention of Acute Chemotherapy-induced Death in Mice by Re- 4130 0-973, a New Platinum Derivative with Potential Antileukemic 4190 Targeting of Tumor Cells and DNA by a Chlorambucil-Spermidine combinant Human lnterleukin 1: Protection from Hematological and Conjugate. Jane L. Hollcy, Andrew Mather, Richard T, Wheelhouse, Nonhematological Toxicities. Giovanna Damia, Kristin L. Activity. Susan O'Bnen, Hagop Kantarjian, Emil Freireich, Dennis Johnston, Kim Nguyen, and Miloslav Beran. Paul M. Cullis, John A. Hartley, John P. Bingham, and Gerald M. Komschlies, Hitoyasu Futami, Timothy Back, M. Eileno Gruys, Dan Cohen. L. Longo, Jonathan R. Keller, Francis W. Ruscetti, and Robert H. 4135 Adriamycin: Protection from Cell Death by Removal of ExtraeeBalar Wiltrout. 4196 Abnormal Structure and Expression of the p53 Gene in }leman Drug. Paul Vichi and Thomas R. Tritton. Ovarian Carcinoma Cell Lines. Yuji Yaginuma and Heiner 4090 Multiparameter Assessment of the Cell Cycle Effects of Bioactive Westphal. and Cytotoxic Agents. Harvey D. Preisler, Venu Gopal, Shripnd D. 4139 Nitrite and Nitrosamine Synthesis by Hepatucytes Isolated from Baoavali. Daniel Finke, and Syed A. J. Bokari. Normal Woodchucks (Marmota mona.r) and Woodchucks Chroni- 4200 Correlation between in Viva Toxicity and Preclinical in Vitro Para- cally Infected with Woodchuck Hepatitis Virus. Run Hal Liu, James meters for the Immunotuxin Anti-B4-blocked Ricin. Michael L. 4096 Increased Therapeutic Eff• Induced by Tumor Necrosis Factor R. Jacob, Bud C, Tennant, and Joseph H. Hotchkiss. a Combined with Platinum Complexes and Whole-Body Hyporther- Grussbard. John M Lambert. Victor S. Goldmacher, Walter A. Bliittier, and Lee M. Nadler, mitt in Rats. Shinji Ohno, Zahid H. Siddik, Frederick R. Strebel, 4144 Inhibition of Hematupoietic Tumor Growth by Combined Treatment L. Clifton Stcphens, Masato Makino, Jim Klostergaard, Stephen P, with Daforoxamtne and an IgG Mooocloeal Antibody against the 4208 In Viva Growth of C6 Glioma Cells Transfected with Connexin43 Tomasovic. Abdul R. Khokhar, and Joan M. C. Bull. Traosferrin Receptor: Evidence for a Threshold Model of Iron Dep- eDNA. Christian C. G. Naus. Kost Elisevich. Daguang Zhu, Daniel 4102 Difference in the Response of nee and ras Oncogeno-induced Rat rivation Toxicity. John D. Kemp. John A. Thorson, Barbara C. J. Belliveau, and Rolando F. Del Maestro. Mammary Carcinomas to Early and Late Ovuciectomy. Bingcheng Stewart. and Paul W. Naumann. Wang, Wendy S. Kennan, Jane Yasukawa-Bames. Mary J. 4214 Chondrucytic Differentiation of Peripheral Neuroectodermal Tumor Lindstrom, and Michael N. Gould. 4149 Development of a Marine Lymphoma Model System for the Char- Cell Line in Nude Mouse Xenograft. Junko Goji, Kimihiko Sano, ucterization of Natural Killer:Tumor Cell Interactions. Glennda Hajime Nakamura, and Hiroshi Ito. 4106 Resistance to Tamoxifen with Persisting Sensitivity to Estrogen: Smithson, R. Michael Wolcott, and Robert Chervenak. Possible Mediation by Excessive Antiestrogen Binding Site Activity. Inhibition of Proliferation by c-myb Antisense RNA and Oligodeoxy- Edward J. Pavlik, Katherine Nelson. Suseela Srinivasan. Deborah E. 4157 Effect of Bivalent Interaction upon Apparent Antibody Affinity: nucleotides in Transformed Neoroectodermal Cell Lines. Giuseppe Powell. Daniel E. Kenady, Paul D. DePriest, Holly H. Gallion. and Experimental Confirmation of Theory Using Fluorescence Photo- gaschell~, Anna Negrooi, Tomasz Skorski, Sabina Pucci, Malgorzam John R. van Nagell, Jr, bleaching and Implications for Antibody Binding Assays. Eric Ned Nieborowska-Skorska, Antonino Romeo, and Bruno Calahretta. Kaufman and Rakesh K. Jain. 4113 Interleukin 6 Reduces Lipoprotein Lipase Activity in Adipose Tissue Pyrimidine Dimer Removal Enhanced by DNA Repair Liposomes of Mice in Viva and in 3T3-LI Adipocytes: A Possible Role for 4168 Development of Antibodies against p53 in Lung Cancer Patients Reduces the Incidence of UV Skin Cancer in Mice. Daniel Yarosh, Interleukin 6 in Cancer Cachexin. Andrew S. Greenberg, Richard P. Appears to Be Dependent on the Type of p53 Mutation. Stefan F. Lori Green Alas, Vivien Yee, Andrew Oberyszyn, Ieannie Tsimis Nordan. Joseph Mclntosh, Juan Carlos Cairo, Robert O. Scow, and Winter, John D. Manna. Bruce E. Johnson, Takashi Takahashi, Adi Kibitcl, David Mitchell, Rebecca Rosenstcin, Alan Spinowitz, and David Jablons. F. Gazdar, and David P. Carbone. Marc Citron,

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4232 Expression of Pintelot-derived Growth Fuctor-independent Pheno- ADVANCES IN BRIEF 4280 Identification of Antisense RNA Transcripts from a Human DNA types in BALB/c 3T3 Cell Variant with High Susceptibility to Topoisomerase I Pseudugene. Bing-Sen Zhou, David R. Beidler, and Chemically or Physically Induced Neoplastic Cell Transformation: 4261 Induction of Transforming Growth Factor ~': in Human Breast Cancer Yung-Chi Cheng Disenciatiun from Activation of Protein Kinose C. Masaaki Tatsuka, in gieo following Tamoxifen Treatment. Anju Butta, Kenneth 4286 Murine Bladder Carcinoma Cells Present Antigen to BCG-specific M. Koji Owada, and Hiromi Mitsui. MacLennan, Kathleen C. Flanders, Nigel P. M. Sacks, ion Smith, Alan McKmna, Mitchell DowseR, Lalage M. Wakefield, Michael B. CD4* T-Cells. Edmund C. Lattime, Leonard G. Gomella, and Peter Sporn, Michael Baum, and Anthony A. Colletta. A. McCue.

4242 Effect of Tastnsterono on the Growth Properties and on Epidermal 4265 Diminished Leukncyte-EndotheHumInteraction in Tumor Microves~ Growth Factor Receptor Expression in the Teratoma-derived Tu- sels. Ning Z. Wu, Bruce Klitzman, Richard Dodge, and Mark W. LETTER TO THE EDITOR mncigenicCell Line 1246-3A. Ginette Serrero, Nancy M. Lepak, Jun Dewhirst. Hayashi, and Dominic P. Eisinger. 4291 Correspondencere: G. Caderni et aL, Effect of Dietary Carbohydrates 4269 Reversal of Divergent Differentiation by co.* Oncugene-medioted on the Growth of Dysplastic Crypt Fuci in the Colon of Rats Treated Tmesfurmatiun. Jie Pan, Calvin D. Roskelley, Van Luu-The, with 1,2-Dimethylhydrazine. Cancer Res. 51: 3721-3725, 1991. Ranjana P. Bird and Theresa P. Pretlow. Reply by Piero Dolara and 4248 DNA Topolsomerase 11 lmmunostaining in Human Leukemia and Mumtaz Rojiani, and Nelly Auersperg. Giovanna Caderni. Rhabdomyourcoma Cell Lines and Their Responses to Topoiso- merase II Inhlbitors. Judith S. Wolverton, Mary K. Danks, Bernd 4273 The Pattern of p53 Mutations in Burkitt's Lympboma Differs from Granzen. and William T. Beck. That of Solid Tumors. Kishor G. Bhatia, Marina i. Guti6rrez, Konrad HuppJ, David Siwarski, and lan T, Magrath. 4293 Announcements Eighty-Fourth Annual Meeting of the AACR 4277 Evidence for a Tumor Suppressor Gene on Chromosome 19r Asso- AACR Special Conferences in Cancer Research 4254 Sqnomuns Metapinsio of Normal tad Carciooma in Sitn of HPV 16- cioted with Human Astrocytomns, Oligndendrogliomes, and Mixed Calendar of Events lmmurtallaed Human Endoesrvieal Cells. Qi Sun, Kouichiro Gliomas. Andreas yon Daimling, David N. Louis, Klaus von Tsutsumi, M. Brian Kelleher, Alan Pater, and Mary M. Pater. Ammon, Iver Petersen, Otmar D. Wiestler, and Ikrnd R. Seizinger. 4296 Author Index

August 15, Number 16

4297 Interlenkin 8 Is Produced in Neoplastic und Infections Diseases of 4402 In Vitro Activationof Distinct Molecular and Cellular Pheootypes 4514 Growth of Human Melanocyte Cultures Supported by 12-O- the Human Central Nervous System. Erwin Van Melt, Miroslav after Induction of Differentiation in a Human Neurohinstoma Cell Tetradecanoylphorhel-13-acetate Is Mediated through Protein Ceska, Fritz Effenberger, Alfred Walz, Eric Grouzmann, Isabelle Line. C. Gaetano, K. Matsomoto, and C. J. Thiele. Kinase C Activation. Yuko Arita, Kevin R. O'Driscoll, and I. Deshaillets, Karl Fret, Adriano Fontana, and Nicolas de Tribolet. Bernard Weinstein, 4408 Preferential Expression of immunoreactire Fneosylceramlle in 4306 Immunological Qanntitatiun of Thymidylate Synthase Using the Adenoearrinoma of the Lung. Hirnyuki Yamada, Hideki lsh,hara, 4522 Cyclin DI Messenger RNA Is Inducible by Platelet-derired Munncionol Antibody TS 106 in 5-Flunrouracil-sensitiveand -re- Hiroshi Kitogawa. Yoshinori Kawabata, Shinji Ituyama, and Growth Factor in Cultured Fibrobinsts. Ewa Surmacz, Krzysztof sistant Human Cancer Cell Lines. Patrick G. Johnston, James C. Isamu Sugawara. Reiss. Christian Sell, and Renato Baserga. Drake. Jane Trepel, and Carmen J. Ailegra. 4413 Role of Enducrine, Autucrine, and Pacacrino Interactions in the 4526 Elevated Membrane Association of Phospholipase C-T 1 in MDA- 4313 Hncmone-regulated Apoptosis Results from Reentry of Differen- Development of Mammary Hyperpinsia in Wnt.I Trunsgenic 468 Mammary- Tumor Ceils. Ann Mangelsdorf Soderquist, tiated Prostate Cells onto a DefectiveCell Cycle. Marc Coinmhel, Mice. Tzu-Piog Lin, Raphael C, Guzman, Rebecca C. Osborn, Gordon Todderud, and Graham Carpenter. Carl A. Olsson, Po-Ying Ng, and Ralph Buttyan. Gudmundur Thordarsen, and Satyabrata Nandi. 4320 Molecular Dnsimetry of Ethylene Oxide: Formation and Persis- 4530 Evidence That the MCC-APC Geno Region in 5q21 Is Not the 4420 Inductiun of Uterine Cervical Ncoplaalas in Mice by Human Pap- tence of N-(2-Hydroxyethyl)valine in Hemoglobin following Re- Site [or Susceptibility to Hereditary Nanpolypnsis Colorectal Car- iliomavirus Type 16 E6/E7 Genes. Toshiyuki Sasagawa. Masaki peated Exposures of Rats and Mice. Vernon E. Walker, John P. cinoma. Palvi Peltomaki, Pertti Sistonen, Jukka-Pekka Mecklin, lnoue, Hirokazu lnoue, Masuo Yutsudo, Osamu Tanizawa, and MacNeela, James A. Swenberg, Max J. Turner, Jr., and Timothy Lea Pylkkgncn, Lauri Aaltonen, Stig Nordling, Juha Kere, Heikki Akira Hakura. R. Fennell. Jarvinen, Stanley R. Hamilton, Gloria Petersen. Kenneth W. Kinzler, Bert Vogelstein, and Albert de la Chapelle. 4328 Molecular Dnsimetry of Ethylene Oxide: Formation and Persis- 4427 Munncionol Antibody MRKI6 Reverses the Multidrug Resistance tence of 7-(2-Hydroxyethyl)gannino in DNA following Repeated of Multidrug-resistant Transgenic Mke. Gerald H. Mickisch. Lee H. Pal, Michael M. Gottesman, and Ira Pastan. 4534 Restricted Oncogenicity of BCR/ABL p190 in Transgenic Mice. Exposunes of Rats and Mice. Vernon E. Walker, Timothy R. Jan Willem Voncken, Stephen Griffiths, Melvyn F. Greaves, Paul Fennen, Patricia B. Upton, Thomas R. Skopek, Virgioie Prevost, K. Pattengale, Nora Heisterkamp, and John Groffen. David E. G. Shaker, and James A. Swenberg. 4433 Combined Antimicrotubule Activity of Estramustinc and Taxol in Human Prostatic Carcinoma Cell Lines. Lisa A. Speicher, Linda 4335 p53 Geae Mutations in Human Gastric Cancer:. Wild-Type p53 Barone, and Kenneth D. Tew. but not Mutant p53 Suppresses Growth of Human Gastric Cancer Cells. Takashi Matozaki. Choitsu Sakamoto. Toshiya Suzuki, 4441 Regulation of Intracelinior pH in Tumor Ceil Lines: Influence of ADVANCES IN BRIEF Kohei Matsoda, Tohru Uchida, Osamu Nakano, Ken Wada, Microenvironmental Conditions. Michael J. Boyer and lan F. Hogara Nishisaki, Yoshitaka Konda, Mnnehiko Nagao, and Ma- Tannuck. sato Kasuga. 4540 Collagen-induced Activation of the Mr 72,000 Type IV Collage- 4448 Cytotoxicity of Straptavklin-blucked BintinyI-Ricio Is Retrieved nase in Normal and Malignant Human Fibroblastoid Cells. Hala 4342 Phase 1 Trial of the Murine Monociunal Anti-GDz Antibody by in Vitro Immunotargetiog via Biotinyl Monocinnol Antibody. S. Azzam and Erik W. Thompson. 14G2a in Metastatic Melanoma. Mansoor N. Saleh, M. B. Bilha Sehechter, Ruth Arnon, and Meir Wilchek. 4545 Stimulation by Bombesin and Inhibition by Bombesin/Gastrio- Khazaeli, Richard H. Wheeler, Edward Dropeho, Tiepu Liu, releasing Peptide Antagonist RC-3095 of Growth of Human Marshall Urist. Donald M. Miller, Sharon Lawson, Pare Dixon, 4453 Radiation Sensitivity in Vitro of Primary Tumors and Metastatic Breast Cancer Cell Lines. Tetso Yano, Jucek Pinski, Kate Grnot, Charles H. Russell, and Alhert F. LoBuglio. Lesions of Malignant Melanoma. Eioar K. Rofstad. and Andrew V. Schally. 4348 Simvastatin, an Inhibitor of Cholesterol Biosynthesis, Shows a 4458 In Vitro Growth Mndulntion by L-Ascorbic Acid of Cniony-fncm- 4f,A8 Correlatian of Serum Metalloproteinase Levels with Lung Cancer Synergistic Effect with N,N'-Bls(2-chioroethyl)-N-nittesunreaand ing Cells from Bone Marrow of Patients with Myeiodysplastlc Metastases and Response to Therapy. Spiridione Garblsa, B-interferon nn Human Glinma Cells. Maurizio R. Soma, Pietro Syndromes. Chen H. Park. Bruce F. Kimler, David Bodensteiner, Giorgio Scagliotti, Laura Masiero. Carla Di Francesco, Cristina Pagliarini, Giorgio Butti, Rodolfo Paoletti, Pietro Paoletti, and Sean R Lynch, and Ruth S, Hassanein. Caenazzo, Maurizio Onisto, Marco Miccla, William G. Reran Fumagalli. Stetler-Stevenson, and Lance A. Liotta. 4356 Epidemml Growth Factor and Transforming Growth Factor a 4467 Amsacrinc and Etoposide Hypersensitivity of Yeast Cells Over- expressing DNA Topoisomerase IL John L. Nitiss, Ya-Xia Liu, 4550 Amplification and/or Overexpression of Platelet-derived Growth Stimulate or Inhibit Proliferation of u Human Renal Adeneearci- Factor Receptors and Epidermal Growth Factor Receptor in Hu- noma Cell Line Depending on Cell Status: Differentiation of the Pelle Harbury, Mehrdad Jannatipour, Robin Wasserman, and James C. Wang. man Glial Tumors. Timothy P. Fleming, Abha Saxena, W. Craig Two Pathways by G Protein Involvement.A. Argil&, N. Kraft, T. Clark, James T. Robectson, Edward H. Oldfield, Stuart A. Ootaka~ P. Hutchinson, and R. C. Atkins. Aaronson, and Iqbal Unnisa All. 4473 Repair of DNA and Chromosome Breaks in Cells Exposed to SR 4361 Cytogenetic Alterations Assuciuted with P-Glycoprotein- and 4233 under Hypexia or to Ionizing Radiation. Jingli Wang, Kim 4554 BroadSpectrum Neumpeptide Antagonists Inhibit the Growth of Non-P-Giycoprotein-mediotedMultidrog Resistance in SW-1573 A, Biedermann. and J. Martin Brown. Small Cell Lung Cancer in Viro. Simon Langdon, Tariq Sethi, Human Lung Tumor Cell Lines. Aggie W. M. Nieuwint, Frank Alison Ritchie, Morwenna Muir, John Smyth, and Enriqne Bans, Joop Wiegant, and Hans Joenje. 4478 Rational Design and Molecular Effects of a New Topoisomerase Rozengurt. II Inhibitor, Azatoxin. Fram;ois Leteurtre, Jose Madalengoitia, 4372 Anoxia-indncible Endunuclease Activity as a Potential Basis of Ann Orr, Timothy J. Cuzi, Erich Lehnert, Timothy Macdonald, the Genomic Instability of Cuncer Cells. Daniel L. Stoler, Garth and Yves Pommier. R. Anderson, Cheryl A. Russo, Annamaria M. Spina, and Terry A. ikerman. 4484 Specific Activntionof Glucuronide Prndraga by Antibody-targeted LETTERS TO THE EDITOR Enzyme Conjugates for Cancer Therapy. Shiog-Ming Wang. 4379 Roleof Cytnchrome P-450 from the Human CYP3A Genc Fumily Ji-Wang Chem, Miog-Yang Yeh, Joyce Co Ng. Edward Tung, 4558 Correspondence re: W. R. Greco et al., Application of a New in the Potentiation of Morpholino Doxorubicin by Human Liver and Steve R. Roffier. Approach for the Quantitation of Drug Synergism to the Combi- Microsomes. Alexander D. Lewis, Derick H. M. Lau. George E. nation of cis-Diamminedichloroplatinum and l-B-wArabinofura- Dur~, C. Roland Wolf, and Brunimir I. Sikic. 4492 Benzopyranones and Benzothinp)'ranones: A Class of Tyrnsine nosylcytasine. Cancer Res., 50: 5318-5327,1990. Protein Kinase Inhibitors with Selectivity for the v-abl Kinase. Letter. Morris C. ikrenbaum. 4385 2: :At-Methylane Blue for Targeted Radiotherapy of Human Mei- Johanna F. Geissler, Joahnnes L. Rcesel, Thomas Meyer, Uwe P. Letter. Jurgen SuhneL aunma Xenogrnfts: Treatment of Cutaneous Tumors and Lymph TrUnks. Peter Traxler, and Nicholas B. Lydon. Reply. William R. Greco and Youcef M. Rustum. Node Metastases. Eva M. Link and Robert N. Carpenter.

4391 Human T-Cell Leukemia Virus Type I or a Related Reteovires in 4499 Rolenfthe as,St lntegrio Receptor in the Proliferative Response of Patients with Mycosis Fungnides/S~zary Syndrome and Kapnoi's Quiescent Human Melanoma Cells to Fibroncctin. Roberta Sarcoma. B. 1. Sahal Srivastava, Katalin Banki, and Andras Purl. Mortarini, Angela Gismondi, Angela Santoni, Giorgio Parmiani, 4566 Announcements and Andrea Anichini. Eighty-Fourth Annual Meeting of the AACR 4396 Disposition Charucterhtics of Macromoloculos in the Perfesed AACR Special Conferences in Cancer Research Tisue~lsoioted Tumor Preparatim. Hirofumi Imoto, Yumi 4507 K-ms Mutation Is an Early Event in Pancreatic Duct Carcinogen- Calendar of Events Sahamura, Kazuhiro Ohkouchi, Ryo Atsomi, Yoshinobu esis in the Syrian Golden Hamster. Wendy L. Ceray, Kathy A. Takakura, Hitoshi Suzuki, and Mitsura Hashida. Mangnld, and Dante G. Scarpelli. 4569 Author Index

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September 1, Number 17

4571 Cellular Events AccompanyingRegression of Skin Recurrences of 4678 Cytogenetic Characterization of B-Cell Lymphomas from Severe 4773 Characterization of Protein Tyrosine Kioases from Human Breast Breast Carcinomas Trented with Intralesionnl Injections nf Nntu- Combined ImmunndefieiencyDisease Mice Given Injections of Cancer: Involvement of the c-src Oncogeue Product. A. E. rul lnterferuns a and % Lueiano Ozzello, David V. Habif, Carolyn Lymphueytes from Epstein-Ban" Virus-positive Donors. Maya Ottenhoff-Kalff, G. Rijksen, E. A. C. M. van Beurden, A. M. De Rosa. and Karl Conrail. Thangavelu, Leslee Snyder, John Anastasi, Michelle M. Le Beau, Hennipman, A. A, Micbels` and G. E. J. Staal. Marybeth Kirven, Gaston Picchio, Donald E. Muster, and Janet 4582 In Vi~o and in Vitro Growth-inhibitory Effect of Bovine Seminal D. Rowley. 4779 Characterization of a Complementary DNA for Rat Liver Aryl Ribonuclease on n System of Rat Thyroid Epithelial Trnnsformed Sulfotronsferase IV and Use in Evaluating the Hepatic Gene Cells and Tumors. Paolo Laccetti, Giuseppe Portella, Maria 4682 Fate and Distribution of 2-Amino-l-methyl-6-pbenylimidazo- Transcript Levels of Rats at Various Stages of 2-Acetylamino- Rosario Mastronicola, Aniello Rosso, Renata Piccoli, Giuseppe [4,5-blpyridiue in Mice at a Human Dietary Eqniralent Dose. fluorene-induced Hepatueuecinogenesis.Tokunbo Ycmkun, Janet D'Alessio, and Giancarlo Vecchio. Kenneth W. Turtehaub, John S. Vogel, Christopher E, Frantz, L. Etheredge, Tom R. Norton, Henry A. Carter, Keun H. Chung, and Nancy Shen. Paul J. Birckbichler, and David P. Ringer. 4587 Clinical Implications of Decreased RetinoblastOma Protein Ex- Mutational Specificity of 1,3-Bls(2-chloruethyl)-l-nitrosoureain 4787 Absence of p53 Geue Mutations in Primary Nasopharyngeal Car- pression in Acute Myelogenons Leukemia. Steven M. Kornblau, a Chinese Hamster Ovary Cell Line. Dana T. Minnick, Martina cinomas. Charles H. Spruck Ill, Yvonne C. Tsai, Dolly P. Huang, Hong-Ji Xn" Auro del Giglio, Shi-Xue Hn, Wet Zhang, Leslie L. Veigl, and W. David Sedwick. Allen S. Yang. William M. Rideout Ill, Mirella Gonzalez- Calvert, Miloslav Baron, Elihu Estey, Michael Andreeff, Jose Zulueta. Peter ChoL Kwok-Wal Lo, Mimi C. Yu, and Peter A. Trujillo. Marjorie A. Cork, Terry L. Smith, William F. Benedict, 4696 Relationship of the Queuiue Content of Transfer Ribonueleic Jones. and Albert Deisseroth. Acids to Histopnthological Grading nod Survival in Human Lung Cancer. Biing-Shiun Hnang, Roog-Tsnn Wu, and Kwang-Yu 4791 Nonrandom Abnormalities InvolvingChromosome 1 and Harvey- 4591 CallCycle Synchronization nod Growth Inhibition by 3-Hydroxy- Chien. ras-I Alleles in Rat Mammary Tumor Progression. C. Marcelo pyridin-4-.one Iron Chelators in Leukemia Cell Lines. Kathariue Aldaz, Aaron Chen, Lauren S. Gollahon, Jose Russo, and Konrad P. Hoyes` Robert C. Hider, and John B. Porter. 4701 Sensitive Detection of Rare Circulating Nearoblastoma Cells by Zappler. the Reverse Transeriptase-Polymerase Chain Reaction. Leonard 4600 Expression of Human Prostatic Acid Phosphatase Activity and A. Mattano, Jr., Thomas J. Moss, and Stephen G. Emerson. 4799 Aberrations of the.uS3 Tumor Suppressor Gene in Human Non- 1he Growth of Prostate Carcinoma Cells. Miog-Fong Lin, Julia Small Cell Cnrciuomnsof the Lung. Yosukc Kisbimoto, Yoshinori DaVolio, and Rencr Garcla-Arenas. 4706 Effecton Cancer Cells of Plasmids That Express Antisense RNA Murakami, Masahiko Shh'aishi, Kenshi Hayashi, and Takao of Human Papiliomovirus Type I8. Cherrilee Stecle, Peter G. Sekiya, 4608 Effect of Treatment Duration nod Glutathiono Depletion on Mit- Sacks, Korea Adler Storthz, and Edward J. Shillitoe. omycin C Cytotoxicity in Vitro. Roger R. Perry, Bridget R. 4805 Human Hepatoma Gnngliosides:-Occuerenceof n Novel l-Type Greaves, Uli Rasberry, and Sam C. Barranco 4712 New S-AdenosylmethioniueDecasboxylnse Inhibitors with Potent Glycolipid with NenAca2-6Gal Structure. Takao Taki, Chiaki Antitumor Activity. Urs Regenass, Giorgio Caravatti, Helmut Rokukawa, Takeshi Kasama, and Shizuo Handa. Mett, Jaroslnv Stanek, Peter Schneider, Marcel Miiller, Alex 4613 Rat Prostate AdenoearcinomaCells Disseminate to Bone and Ad- Matter, Paula Vertino, and Carl W. Porter. here Preferentially to Bone Marrow-derived Endothelial Cells. 4812 Selenite Cytotoxicity in Drug Resistant ond Nooresistaut Human Ovarian Tumor Cells. Paula B. Caffrey and Gerald D. FrenkeL Mahmudul Haq, David Goltzman, Gilles Tremblay, and Patna 4719 Influence of Tnmoxifen on Plasma Levels of Insulin-like Growth Brodt. Factor I nod Insulin-like Growth Factor Binding Protein I in Breast Cancer Patients. Per Eystein Lenning. Kerstin Hail, 4620 Quantitative Changes in Tumor Metabolism, Partial Pressure of Asbjern Aakvaag, and Ernst A. Lien. ADVANCES IN BRIEF Oxygen, and Radiobiologieal Oxygenation Status Postrudlation. Jason A. Koutchec, Alan A. Alfieri, Mary L. Devitt, Juong G. 4724 K-ms Activation in Non-Small Cell Lnog Cancer in the Dog. Rhea, Alice B. Kornblith, Umar Mahmond, Thomas E. Susan A. Kraegel, Paul H. Gumerlock, Donald L. Dungworth, 4817 Antibody-modiated Specific Binding and Cytotoxicity of Lipo- Merchant, and David Cowburo. Victor I. C. Oreffo, and Bruce R. Madewen. some-ontrapPnd DOxorubicin to Lung Cancer Cells in Vitro. Imran Abroad and Theresa M. Alien 4628 Elevation of Free 6' Subunit of Human Chorioganodotmpin 6' and 4728 Comparisons between Two Monoclonal Antibodies That Bind to 4821 Platelet.-derivedGrowth Factor-induced Transcription of the Vas- Core B Fragment of Human Choriogonodotropin in the Serum and the Same Antigen but Have Differing Affinities: Uptake Kinetics cular Endothelial Growth Factor ls Mediated by Protein Kinase Urine of Patients with Malignant Pancreatic nod Bihary Disease. nod =2Sl-Antibody Therapy Efficacy in Multicell Spheroids. C. Giinter Finkenzelier, Dieter Marm~, Herberl A. Welch, and Henrik Alfthan, Caj Haglund, Peter Roberts. and UIf-H~kan VL,'g[naK. Laogmuir, Holly L. Mendonca, and David V. Woo. Hubert Hug. Stenmon. 4735 Reveraal of Maltidrug Resistance by Two Novel Indole Ikriva- 4824 DNA Polymerase 6' Mutations in Human Coiorectal Cancer. 4634 Ioduetiou by Bnfalin of Differentiation of Hnnum Lenkemla Cells tives. Sunil Kadam, Mary Maus, Jennifer Poddig. Steven Liming Wang. Umesh Patel, Lagn~jita Ghosh, and Sipra HL60, U937, and MLI toward Muerophage/Monocyto-like Cells Schmidt, Ronald Rasmussen, Eugene Novosad, Jacob Platmer, Boncrjee. and Its Potent Synergistic Effect on the Differentiation of Haman and James McAIpiue. Leukemia Cells in Combination with Other Inducers. Lisha 4828 Accumulationof p53 Protein Correlates with n Poor Prognosis in Zhong, Kazuyasu Nakaya, Takemi Yoshida, and Yukio Kuruiwa. Mucins Bearing the Cancer-asseclated Slaiosyl-Tn Antigen Me- Human Lung Cancer. Dennis C. Quinlan, Ann G, Davidson, diate Inhibition of Natural Killer Cell Cytoloxicity. Shunichiro Carol L. Summers, Herbert E. Warden, and Himanshu M. Doshi. 4642 Down-Regulationof Teonscin Expression by Antiprogestins dur- Ogata, Peter J. Malmonis, and Steven H. Itzkowitz, ing Terminal Differentiation of Rat Mnmmary Tumors. Gi~nter 4832 Occurrence of p53 Gene Deletions and Human Papilloma Virus Vollmer, Horst Micbna, Kirsten Ebert, and Rudolf Knuppen. 4747 GGT to G'rr Trausversions in Codon 12 of lhe K-ras Oncogene in Infection in Human Head and Neck Cancer. David G. Brachman, Rat Renal Sarcomas Induced with Nickel Subsulfide or Nickel Deborah Graves, Everett Vokes, Michael Beckett, Daniel Haraf, Subsnlfide/Iron Are Consistent with Oxidative Damage to DNA. Antony Montag, Edward Dunphy, Roscmarie Mick, David 4649 Analysis of T-Cell Receptor a/B Varinbility in Lymphueytes In- Yondell, and Ralph R. Weichselbaum. filtrating a Melanoma Metastasis. Laurent Ferradini, Sergio Kathleen G. Higinbotham, Jerry M. Rice, Bhalchandra A. Diwan, Roman-Roman, Jos~ Azocar, Marie-Franfoise Avril, Sophie Kazimierz S. Kasprzak, Carl D. Reed, and Alan O. Perantoni. Viel, Frtd~ric Triebel, and Thierry Hercend. 4752 Elevated DT-Dlaphoruse Activity nnd Messengec RNA Content 4655 Expression nnd Characterization of Mueins Associated with the in Human Non-Small Cell Lung Carcinoma: Relationship to the MEETING REPORT Resistance to Methotrexate of Hnman Colonic Adonoearcinoma Response of Lung Tnmor Xenogrufts to Mitomyein C. Alvin M. Cell Line HT29. Rajvir Dahiya, Th~cla Losoffieur, Kyu-Shik Malkinson, David Siegel, Gerald L, Forrest, Adi F, Gazdar, 4837 Multistage Carcinogenesis: The Twenty-Second International Kwak, James C. Byrd, Alain Barbat, Alain Zweibaum, and Young Herbert K. Oie, Danicl C, Chan. Paul A. Bunn, Mack Mabry, Symposium of the Princess Tnkamotsu Cancer Research Fund. S. Kim. Donald J. Dykes, Steadman D. Harrison, Jr,. and David Ross. Curtis C. Harris, Setsuo Hirohashi, Nobuyuki ho, Henry C. Pitot, Takashi Sogimura, Masaaki Terada, and Jun Yokota. 4663 Comparative Antitumar Effects of Hormonal Ablation, Estrogen 4758 Resistance of Human Cervical Carcinoma Cells to Tumor Necro- Agonist, Estrogen Cytotoxic Derivntive, and Antiestrogen in the sis Factor Correlates with Their I~sed Sensitivity to Cisplatin: PAIII Rat Prostatic Adenoearciooma.Blake Lee Neubauer, Kevin Evidence urn Rule for DNA Repair and Epidermal Growth Factor L. Best, Robin L. Goode, Mark L, Heiman, Dennis M. Hoover, Receptor. Kiyohiru Nishikawa, Michael G. Rosenblum, Robert A. 4841 Announcements David W. Robertson, Michael F. Sarosdy, Carl J. Shaar, Lee R. Newman, Tcj K. Pandita, Walter N. Hittelman, and Nicholas J. Eight-Fourth Annual Meeting of the AACR Tanzer, and Ronold L, Merriman. Donato. AACR Special Conferences in Cancer Research Calendar of Events 4672 BoronNeutron Capture Therapy"for Marine Malignant Gliomas. 4766 Differential Susceptibility of Cultured Human Melanoma Cell Stephen C. Saris, Guido R. Solares, David E, Wazer, Guillermo Lines to Enhancement by Retinoic Acid of Intercellular Adhesion 4844 Employment Register of the AACR Cano, Sarah E. Kerley, Melita A. Joyce, Luster S. Adelman, Otto Molecule i Expression. Zhigang Wang, Yan Cao, Claudio M. K. Harling, Hywel Madoc-Joncs, and Robert G. Zamenhof. D'Urso, and Soldano Fen'one, 4852 Author Index

September 15, Number 18

PERSPECTIVES IN CANCER RESEARCH 4885 Urinary Mutagenicity and N~Acetylation Phenotype in Textile 4929 Structural Chromosome I Aberrations in Transitional Cell Carci- Industry Workers Exposed to Arylamincs, B. Sinu~s. J. Perez, M. noma of the Bladder: lnterphase Cytogenetics Combining n Cen- 4853 I.,uealCytokine Availability Elicits Tumor Rejection and Systemic L. BeruaL M. A. Saenz, J, Lanoza, and M. Bartolome. trumeric, Telnmeric, and Library DNA Probe. Pino J. Poddighe, Immunity through Granulueyte-T-Lymphocyte Cross-Talk. Frans C. S. Ramaekers, A. Wire G. B. Smeets, G. Peter Vooijs` Mario P. Colombo, Andrea Modesti, Giorgio Parmiani, and 4890 Induction of Intercellular Adhesion Molecule l on Small Cell and Anion H. N. Hopman. Guido Forni. Lung Carcinoma Cell Lines by "y-lntecferon Enhances Spontaue- oas and Bispecific Anti-CD3 x Antitumnr Antibody-directedLym- 4935 Low Mituehondrial Proton Leak Due to High Membrane Choles- phokine-activated Killer Cell Cytotoxicity. Arata Azuma. Hidco terol Content and Cytosnlic Creatiue Kinase as Two Features of Yagita, Hironori Matsuda, Ko Okumara, and Hisanobu Niitani. the Deviant Biuenecgetics of Ehrlich and AS30-D Tumor Cells. Loris G Baggetto, Eric Clottes, and Christian Vial. 4858 Newt Sqnnmous Carcinoma Proves Phylogeneric Conservation of 4895 Metabolic Effects and Kill of Haman T-Cell Leukemia by 5-Dea- Tumors as Caricatures of Tissue Renewal. Nikolaos P. Zilakos, zancyclotetrahydrofolate,a Specific Inhibitor of Glyciueamide Ri- 4942 Expression of Mntrix Metalloproteinase Genes in Transformed Panagiotis A. Tsonis` Katia Del Rio-Tsonis` and Ralph E. bonucleotide Traasformylase. Gary K. Smith, David S. Duch. Rat Cell Lines of High and Low Metastatic Potential, Taduru Parchment. Inderjit K. Dev, and Scotl H. Kaufmann. Sreenath, Lynn M. Matrisian, William Stetler-Stevenson, Sebastiano Gattoni-Celli, and Rudy O. Pozzatti. 4866 4-Hydroxynonenal, a Product of Cellular Lipid Peruxidation, 4904 Cytotoxiciq,'ond Antitumor Activiq,'of Carzelesin, a Prodrug Cy- 4948 Cell Surface Accessibilityof Individual Gonglinsides in Malignant Which Modulates c-myc and Globin Gene Expression in K562 cloprupylpyrruloindole Analogue. L. H. Li, T. F. DeKoning, R. C. Melanoma Cells to Antibodies Is Influenced by the Total Gangli- Erythroleukemic Cells. Vito M. Fazio, Giuseppina Barrera. Kelly. W. C. Krueger, J. P. McGovren, G. E. Padbury, G. L. oside Composition of the Cells. Kenneth O. Lloyd, Claudia M. Stefano Martinotti, Maria Giulia Farace, Barbara Giglioni, Luigi Petzold, T. L, Wallace, R. J. Ouding. M. D. Prairie. and I. Gordon, Immac J. Thampoe, and Cheryl DiBenedetto. Frati, Vittorio Manzari, and Mario U, Dianzani_ Gebhard.

4914 The Role of Microvascalar Damage in Pbotodynamk Therapy: 4954 Specific Inhibition of Intecleukin 16' Gene Expression by an An- 4872 Antitumoral Activity of Bombosin Analogues on Small Cell Lung The Effect of Treatment on Vessel Constriction. Permeability, and tisense Oligonucleotide: Obligatory Role of Interleukin ! in the Cancer XenogruRs: Relationship with Bombesin Receptor Expres- Leukocyte Adhesion. Victor H. Fingar. T. Jeffery Wieman, Generation of Lymphokiue-activated Killer Cells. Toshiyoshi sion. Francois Thomas, Francisco Arvelo, Etienne Antoine, Sandra A. Wiehle. and Patricia B. Cerrito. Fujiwara and Elizabeth A. Grimm. Michelle Jacrot, and Marie France Poupon. 4922 Elevation of Thymidylate Synthase following 5-Fluoroueacil 4960 9y-Interferon Increases Metaindobenzylguanidine Incorporation 4878 Suppression of Melanoma Ceil Motility Factor Receptor Expres- Treatment is Prevented by the Addition of Leucovorin in Marine and Retention in Human Neumbinstoma Cells. Paolo Giuseppe sion by Retinoie Acid. Reuben Loton, Brad Amos, Hideomi Colon Tumors. Clasina L. Van der Wilt, Herbert M, Pinedo, Kces Montaldo. Roberta Carbone, Mirco Ponzoni, and Paolo Watanabe, and Avraham Raz. Staid, and Godefridus J. Peters. Cornaglia-Ferraris,

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. CONTENTS OF VOLUME 52

4965 Effectsof Hyperthermia on Blood Flow and cis-Diamminodichin- 5030 Human Urinary Bladder Carcinoma Glycneonjugates Expressing ADVANCES IN BRIEF rupiatinum(ll) Pbarmaeakinetics in Marine Mammary Adenocar- T-(Galfl(I-3)GalNAcaI-O-R) and T-like Antigens: A Compara- cinomas. P. L. Ausmus, A. V. Wilke, and D. L. Frazier. tive Study Using Peanut Agglutinin and Poly- and Monoclonal 5096 Cytotoxicity of Clostridium difficile Toxin A for Human Colonic Antibodies. Nicls C, Langkilde, Hans Wolf, Henrik Clausen, and and Pancreatic Carcinoma Cell Lines. Vladimir M. Kushnaryov, 4969 Tamoxifen Suppresses Tumor Promoter-induced Hydrogen Per- Torben F. Omtoft, Philip N. Redlich, J. James Sedmak, David M. Lyeriy, Tracy D. oxide Formation by Haman Neutrophils. Jong Shiaw Lira, Wilkins, and Sidney E. Grossberg. Krystyna FrenkeL and Walter Troll. 5037 Msmmary Tumor Induction by N-MethyI-N+nitresource in Ge- netically Resistant Copenhagen Rats. Shi-Jiang Lu, Guy Laroye, 5100 IGFBP-3 Gene Expression and EsU'ogen Receptor Status in Hu- 4973 Antipruliferative Effects of the Somatostarin Analogue Octreotide and Michael C. Archer. (SMS 201-995) on ZR-75-1 Human Breast Cancer Cells in Viro man Breast Carcinoma. Z-M. Shao, M. S. Sheikh, J, V. Ordonez, and in Vitro. Gisbert Weckbecker, Rong Liu, Levente Tolcsvai, Pei Feng, T. Kute, J-C, Cben* S. Aisner, L. Schnaper, D. LeRoith, and Christian Brans. 5042 High Incidence of Hepatoeellular Carcinomas Induced by a Cho- C. T. Roberts, Jr., and J. Fontana. line Deficient L-Amino Acid Defined Diet in Rats. Dai Nakae, 4979 Chemoprevention of Rat Liver Carcinogenesis by S-AdenosyI-L- Hitoshi Yoshiji, Yasushi Mizumoto, Kohsoke Horiguchi, Kazumi 5104 Expression of the Cellular Adhesion Molecule E-Cndherin Is Re- mcthionine: A Loog-Term Study. Rosa M. Pascale, Vineenzo Shiraiwa, Kazutoshi Tamura+ Ayumi Denda, and Yoichi Konishi. duced or Absent in High-Grude Prostate Cancer. Rainy Umbas, Marras, Maria M. Simile, Lucia Daino, Giampaola Pinna, Jack A. Schalken, TallyW. Aalders, Bob S. Carter, Herbert F+ M. Simona Bennati, Monica Carla, Maria A. Seddaiu, Giovanni 5O46 Multiple Secretion of Matrix Serine Proteianses by Human Karthaus, H. Ewout Schaafsma, Frans M. J. Debruyne, and Massarelli, and Francesco Fen. Gastric Carcinoma Cell Lines. Naohiko Koshikawa, Hidetaro William B. lsaacs. Yasumitso, Makoto Umeda, and Kaoro MiyazakL 4987 A New Tumor-associated Antigen Useful for Serndiognusis of 5110 Microvuscuiar Pressure Is the Principal Driving Force for Inter- Hepalocellular Carcinoma, Defined by Monocional Antibody stltial Hypertension in Solid Tumors: Implications for Vascular 5O54 Localization of Flnorine-18-iabeled MeI-14 Monoclonal Antibody KM-2. Yasoyuki Kumagai, Joe Chiba. Tetsotaro Sara, Sachi Collapse. Yves Boucber and Rakesh K. Jain. Ohtaki, and Keiji Mitamura. F(ab')2 Fragment in a Subcutaneous XenogcaftModel. Pradeep K. Garg, Sudha Garg, Darell D. Bigner, and Michael R. Zalutsky. 5115 Increase in 3,-GlutamylcysteineSynthetose Activity and Steady- 4995 Acidic Fibrubiast Growth Factur-Pseadomonas Exotoxin Chi- State Messenger RNA Levels in Mdphaian-resistant DU-145 meric Protein Elicits AntiaogiogeoicEffects on Endothelial Cells. 5061 Role of p53 Mutations in Endocrine Tumorigenesis: Mutation Human Prostate Carcinoma Cells Expressing Elevated Gin- June Rue Merwin, Mark J. Lynch, Joseph A. Madri, Ira Pastan+ Detection by Pulymerase Chain Reaction-Single Strand Confor- tathione Levels. Howard H. Bailey, Jerry J. Gipp, Maureen and Clay B. Siegall. marion Polymorphism. Katsuhiko Yoshimolo+ Hiroyuki Iwahana. Ripple+ George Wilding, and R. Timothy Mulcahy. Ayumi Fukuda, Toshiaki Sano, Shiro Saito, and Mitsuo ltakura. 5002 Folate Deficiency Enhances the Developmentof Colonic Neopias- ia in Dimcthylhydrazine~treatedRats. Marilia L. Cravo, Joel B. 5119 Unifneal Origin of Advanced Human Epithelial Ovarian Cancers. 5065 Activation of the irons GoomeU'yin Platinum Antitamar Com- Mason. Yogeshwar Dayal, Martba Hutchinson, Donald Smith, Chi-Ho Mok, Sai-Wah Tsao, Robert C. Knapp, Paula M. plexes: A Survey of the Cytotoxiciq,' of trans Complexes Contain- Jacob Selhub. and Irwin H. Rosenberg. Fishbangh, and Chang C. Lno. ing Planar Ligands in Marine LI210 and Human Tumor Panels 5007 Differential Chromatin Structureqlependen! Binding of 7-Amino- and Studies on Their Mechanism of Action. Nicholas Farrell. 5123 Protection from Chemotherupy-indnend Alopecin by 1,25-Dihy- actinomycin D in Normal and Mnlignant Bone Marrow Hematn- Lloyd R. Kelland, John D. Roberts, and Marijo Van Beusichem. druxyvitamin D3. Joaquin J. Jimanez and Adel A. Yunis. poietic Cells. Trond Stokke, Harald Holte, Erlend B. Smeland, Sverre O+ Lie, and Harald B. Steen. 5073 Inhibition of Anglogeaesis by Surumin. A. Gagliardi, H. Hadd, and D. C. Collins. 5126 Radon-induced Deletions in Human Cells: Role of Nonhomoln- 5013 Cullaterul Sonsitivity to Nitrosonreas in Multidrug-resistant Cells gnus Strand Rejoining. Louise H. Lutze, Richard A. Winegar, Selected with Verupamil. Bernard W. Futscher, Kimberley 5076 Cellular Kinetics of Rat Mammary Gland Terminal End Bud Ep- Rick Jostes, Fredrick T. Cross, and James E. Cleaver. Campbell, and William S. Dalton. ithelinm Exposed to N-MethyI-N-nitrosm~ca in Viro. Conwell H, Anderson and Craig W. Beattie. 5018 Oneogenie Human Pnpillomavirus Type 16 Is Associated with 5082 Ectopic Expression of Epidermal Growth Factor Receptors In- Squamoas Cell Cancer of the Male Urethra, John S. Wiener, duces Hormone Independence in ZR-75-1 Human Breast Cancer Edison T. Liu, and Philip J. Waltber. 5130 Announcements Cells. Ton van Agthoven, Thecla L. A. van Agthoven, Hunk Eighty-Fourth Annual Meeting of the AACR Portengen, John A. Foekens, and Lambert C. J, Dorssers. 5024 Differences in Basic Fibrubinst Growth Factor RNA and Protein AACR Special Conferences in Cancer Research Calendar of Events Levels in Human Primary Meianneyles and Metastatic Mela- 5089 A Novel Gene (HIP) Activated in Human Primary Liver Cancer. noma Cells. Douglas T. Yamanishi, Mark J. Graham, Robert Z. Chantal Lasserre, Laurence Christ& Marie-Th~rt~se Simon, FIorkiewicz, Jolie A. Buckmeier+and Frank L. Meyskens, Jr. Philippe Vernier, and Christian Br~chot, 5133 Author Index

October 1, Number 19

5135 Microscopic Localization of Sterically Stabilized Liposomes in 5223 Expression and Functional Role of the p75 lntecleukin 2 Recep- 5299 Phusphomus Metabolite and Cell Cycle Kinetic Response of Two Colon Carcinoma-bearing Mice. S. K. Huang, K-D. Lee, K. Hong, tor Chain on Leukemic Hairy Cells. Livio Trentin, Renato Human Squamous Cell Carcinomas to Radiation. Srinivasan D. S. Friend, and D. Papohadjopoulos. Zambello, Claudia BenatL Marco Cassatella, Carlo Agostini, Vijayakumax, Lech Czerski, Anthony Majors, Rafael Valenzoela, Pietro Bulian, Fausto Adami, Giuseppe Carra, Giovanni Pizzolo, Mike Beckett, Ralph Weichselbaum, and Thian Ng. 5144 Micropharmneology of Monodonal Antibodies in Solid Tumors: and Gianpietro Semenzato. Direct Experimental Evidence for a Binding Site Barrier. Malik 5307 Highly Sensitive, Specific Detection of O6-Methyignonine, Juweid, Ronald Neumann, Chaing Pail Miguel J. Perez-Bacete, 5229 Amplification of Genos within the Chromosome 11ql 3 Rogion ls O4-Methylthymine, and O4-Ethylthymine by the Combination of Jun Sato, William van Osdol, and John N. Weinstein+ Indicative of Poor Prognosis in Patients with Oporuble Breast Hlgh-Perfarmance Liquid Chromatography Prefructlanation, s2p Cancer. Ed Schuuriog, EIs Verhoeven* Harm van Tinteren, Pusriabeling, and Immunoprecipiturion. Ho-il Kang. Chieko 5154 P-Glycoprotein Expression during Tumor Progression in the Johannes L. Peterse, Brigitte Nunnink, Frederic B. J. M. Konishi, Gertrud Eberle, Manfrcd F. Rajewsky, Toshio Kuroki, Rat Liver. Grace Bradley, Radhakant Sharma, Srinivasan Thunnissen, Peter Devalue, Cues J. Cornelissr Marc J. van de and Nam-ho Huh. Rajalakshmi, and Victor Ling. Vijver, Wolter J. Moon, and Rob J. A. M. Michalides. 5313 Putceacine-dependentInvasive Capneity of Rat Aacites Hepatoma 5162 Development of Liver Tumors in Transforming Growth Factor a 5235 Tumor Progression in Viw. Increased Soybean Agglutinin Lee~n Cells. Yoshiyuki Ashida, Jun-ichi Kido, Fumiyo Kinoshita, Truusganic Mice. Gang-Hong Lee, Glenn Merlino, and Nelson Binding, N-Acetylgainctosamine-speciBcLectin Expression, and Mizuho Nishino, Kiyoko Shinkai, Hitoshi Akedo, and Hideo Fausto. Liver Metastasis Potential. Martin R. Reese and Donna A. Chow. Inoue. 5171 Molecular and Generic Analysis of Liver Oncogenosis in Trans- forming Growth Factor a Trunsganic Mice. Hitoshi Takagi, 5244 Homogeneously Staining Region in Anthrucycline-resistant HL- 5317 Involvement of the Spleen in Preleukemic Development of a Richard Sharp, Christine Hammermeister, Tamra Goodrow, 60/AR Cells not Associated with MDR! Amplification. James Marine Retrovirus-induced Promonocyfic Leukemia. Kathryn Matthews O+ Bradley, Nelson Fausto, and Glenn Merlin<)+ E. Gervasoni, Jr,, Robert N. Taub, Ming Tsang Yu, Dorothy Nason-Burchenal and Linda Wolff. Warlmnon, Marlene Sabbath, Stephanie Gilleran, Donald L. 5178 Establishment of the Human BSMZ Breast Cancer Cell Line, Coppock, John D'Alessandri, Sindu Krishna, Michelle Rosodo, 5323 Alterations of the p J3 Geae in Human Primary Cervical Carci- Michael A. Baker, Jose Lutzky, Eva R. Chanda, James H. noma with and without Human Papillomavirus Infection. Masami Which Overexpresses the erbB-2 and c-myc Genes. Michiko Gerlach, Michael J. Pinkoski, Susan P. C. Cole, and Alexander A. Watanabe, Hisako Tanaka, Minori Kamada, James H. Okano, Fujita, Masaki [none, Osamu Tanizawa, Seiichi lwamoto, and Hindenburg. Hiroki Takahashi, Ken Uchida, Akira lwamura. Mikio Zeniya, Takayuki Enomoto. and Tsoneya Ohno. 5250 Antisense-mediated Specific Inhibition of PI20 Protein Expres- 5329 Marked Enhancement of Rat Urinary Bladder Carcinogenesis by 5183 AdopriveTransfar of V~'2-deleringAcririty with Host Cells from sion Prevents GI- to S-Phase Transition. Anna Fonagy, Carol Heat-killed Esckerichin coil Masashi Yamamoto, Howard H. Mice Implanted with C4 Preneoplastie Hyporplusric Alveolar Swiderski, Melissa Dunn, and James W. Freeman. Wu, Hitoshi Momose, Alfred Rademaker, and Ryoichi Oyaso. Nodules. Wei-Zen Wei, Hoog Wang, Richard Ficsor-Jacobs, and Robert Pauley. 5257 Epigenetic Sileneiog of the DNA Relmk Eneymr O+-Methylgno- 5334 Expression of the Class VI Intermediate Filament Nesrin in Hu- nine-DNA Methyilrunsferase in Mex- Human Cells. Sarah man Central Nervous System Tumors. Jonas Dahlstrand, V. Peter 519~ Loss of Epithelial Markers and Acquisition of Vimenrin Expres- Cairns-Smith and Peter Karran+ Collins+ and Urban Lendabl. sion in Adrlamycin-and Vinblastine*resistunt Human Breast Can- car Cell Lines. Connie L. Sommers, Susan E. Heckford, Jeffrey 5264 CD24, a Signal-transducing Molecule Expressed on Human B 5342 Simian Virus 40 Large T Antigen Directed by Transcriptional M. Skerker, Peter Woriand, Jeffrey A. Torri, Erik W. Thompson, Cells, Is a Major Surface Antigen on Small Cell Lung Carcino- Elements of the Human Surfnetant Protein C Gone Produces Stephen W. Byers, and Edward P. Gelmann. mas. David Jackson, Robert Waibel, Erich Weber, John Bell, and Pulmonary Adenocarcinomus in Tcansgenic Mice. Kathryn A. Rolf A. Stahel. Wikenheiser, Jean C. Clark, R. llona Linnoila, Mildred T. 5198 Cathepsin D as a Prognostic Indicator for Node-negative Breast Stahlman* and Jeffrey A. Whitsett. Cancer Patients Using Both lmmuneassays and Enzymatic 5271 Enhanced Sensitivity of Human Colon Tumor Cell Lines in Vitro Assays. Timothy E. Kate, Zhi-Ming Shao, N. Keith Sugg, Rena in Response to Th~hemoimmanothecepy, Jim KIostergaard, 5353 Dlflerentlal Inhibition of the Epidermal Growth Factar-, Piatelet- T. Long, Gregory B. Russell, and L. Douglas Case. derived Growth Factor-, and Protein Kinuse C-mediated Signal Elena Leroux, Zahid H. Siddik, Mojgan Khndadadian, and Trunsdnetion Pathways by the Stanrosporine Derivative CGP Stephen P. Tomasovic. 5204 Insulln-like Growth Factor Binding Proteins in Human Breast 41251. Elisabeth Andrejauskas-Buchdunger and Urs Regenass. Cancer Tissue. Fredrika Pekonen, Tuulikki Nyman, Vesa ilvesmaki, and Seppo Partanen. 5278 Endogenous Tumor Necrosis Factor Exerts Its Protective Func- 5359 Steady-State Messenger RNA and Activity Correlates with Sen- tion lntrneeUulnelyagainst the Cytotoxicity of Exogenous Tumor sitivity to N ~,N t2-Bis(ethyl)spermine in Human Cell Lines Rep- 5208 Product of the Steel Locus Can Replace Leukemic Cell Interac- Necrosis Factor. Tetsuro Okamoto, Naoki Watanabe, Naofumi resenting the Major Forms of Lung Cancer. Robert A. Casero, Jr., tion. Julio R. Cfi'.:eres-Cortts and Trang Hoang. Yamanehi, Yasushi Tsoji, Naoki Tsuji, Yoshinori ltoh, Hiroshi Amy R. Mank, Lea Xiao, Jeffrey Smith, Raymond J. Bergeron, Neda, and Yoshiro Niitso. and Paul Celano. 5213 FlowCytometric Detection of Drugs Altering the DNA Methyln- tion PaRern. Denis S. F. Biard, Michel Maratrat, V~roniqoe 5282 Selenoperuxidaso-mediatedCytoprotecrion ngaiust Merucyanine 5364 Association between Hepatitis C Virus and Hepatneelinlar Carci- Thybaud, Ctline Melcion, and Alain Sarasin. 540-seusitized Photoperoxidarion and Photukilling of Leukemia noma Using Assays Based on Structural and Nonstructurul Hep- Cells. Fabao Lin, Peter G. Geiger, and Albert W. Girotti. atitis C Virus Peptides. Xenophon Zavitsanos, Angelos Hatzakis, 5219 Qanntitative Imoging of a Radiotherapeuric Drug, Na2B~2HI.SH, Evangelia Kaklamani, Anastasia Tzonou, Nektaria Toupadaki, at Subeellular Resolution in Tissue Cultures Using Ion Micro- 5291 p53 Mutations in Breast Cancer. Christopher Coles, Alison Caryn Broeksma, Jurgen Chrispeels, Hugo Troonen, Stephanos scopy. Xinohui Zha, Waller A. Aussercr, and George H. Condie, Udi Cherty, C Michael Steel, H, John Evans. and Jane Hadziyannis, Chung-cheng Hsieh, Harvey Alter, and Dimitrios Morrison. Prosser. Trichopoulos.

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5368 Frequent Loss of Heterozygosity for Loci on Chromosome 8p in ADVANCES IN BRIEF 5407 br Gone Transfer Increases Relative Resistance of $49.1 and Hepatueelluinr Carcinoma, Colorectal Cancer, and Lung Cancer. WEHi7.2 Lymphoid Cells to Cell Death and DNA Fragmentation Mitsuru Emi, Yoshiyuki Fujiwara, Toshifusa Nakajima, Eiju Induced by Glueocorticoids and Multiple Chemotherapeutic Tsochiya, Hitoshi Tsoda, Setsuo Hirohsshi, Yoshiharu Maeda, 5391 Postvaccinal Sarcomas in the Cat: Epidemiolngy and Elec- Drugs. Toshiyuki Miyasbita and John C. Reed. Kouji Tsoruta, Michiko Miyaki, and Yusuke Nakamura. tron Probe Micr~nalytical Identification of Aluminum. Mattie J. Hendrick, Michael H. Goldschmidt, Frances S. Shofer. Yun-Yu 5412 in Viroand in Vitro Characteristics of lnterleukin 6-transfected Wang, and Andrew P. Somlyo. BI6 Melanoma Cells, Wen H. Sun, Regina A, Kreisle, Anthony 5373 Cyeinphosphamide Resistance in Medulloblastoma. Henry S. W. Phillips, and William B. Ershler. Friedman. O. Michael Colvin, Scot! H. Kaufmann, Susan M. 5395 A Synthetic Antagonist to Laminin Inhibits the Formation of Os- teolytic Metastases by Human Melanoma Cells in Nude Mice. Lndeman, Nancy Bullock, Darer D. Bigner, and Owen W. 5416 An Ovarian Tumor Marker with Homology to Vaceinia Virus Masamichi Nakai, Gregory R. Mundy, Paul J. Williams, Brendan Griffith. Contains an lgV-like Region and Multiple Transmembraue Do- Boyce. and Toshiyuki Youeda. mains, Ion G. Campbell, Paul S. Fmemont, William Foulkes" and John Trowsdale. 5379 Moaevalent Immunotoxin Containing Tnm~led Form of 5400 Activation of Omental Milky Spots and Milky Spot Macropheges Paeudomonas Exotoxin as Potent Antitumor Agent. Waldemar by lntraperitonoal Administration of a Streptococcal Preparation, Debinski and Ira Pastan. OK-432, Masataka Shimotsoma. Max W. Simpson-Morgan, and Toshio Takahashi, 5421 Announcements 5386 Effects of Tamoxifen Adjuvant Therapy and a Low-Fat Diet on 5403 Reduced Expression of the Low Affinity Nerve Growth Factor Eighty-Fourth Annual Meeting of the AACR Serum Binding Proteins and Estradiol Bioavailability in Post- Receptor in Benign and Malignant Human Prostate Tissue and AACR Special Conferences in Cancer Research menopausal Breast Cancer Patients. David P. Rose, Rowan T. Loss of Expression in Four Human Metastatic Prostate Tumor Calendar of Events Chlebowski, Jeanne M. Connolly, Lover A. Jones, and Ernst L. Cell Lines. Beth R. Pflug, Makoto Onoda~ John H. Lynch, and Wynder. Daniel Djakiew. 5424 Author Index

October 1, Number 19, Supplement

Preface The Editors ...... 5429s Introduction 1 Myron Essex ...... 5430s Introduction H Pelayo Correa ...... 5431 s

Part 1: Time Trends and Pathological Classification

Non-Hodgkin's Lymphoma Time Trends: United States and International Data Susan S. Devesa and Thomas Fears ...... 5432s Changes in the Descriptive Epidemiology of Non-Hodgkin's Lymphoma in Great Britain R. A. Cartwright ...... 5441s Time Trends of Non-Hodgkin's Lymphoma: Are They Real? What Do They Mean? Theodore R. Holford, Tongzhang Zheng, Susan T. Mayne, and Lisa A. McKay ...... 5443s An Overview of the Classification of Non-Hodgkin's Lymphomas: An Integration of Morphological and Phenotypical Concepts Elaine S. Jaffe, Mark Raffeld, L. Jeffrey Madeiros, and Maryalice Stetler-Stevenson ...... 5447s Changes in Diagnosis of Non-Hodgkin's Lymphomas over Time Peter M. Banks ...... 5453s Pathological Classifications of Non-Hodgkin's Lymphoma for Epidemiological Studies Dennis D. Weisenburger ...... 5456s Discussion...... 5462s

Part II: Genetic and Environmental Determinants

Primary lmmunodeficiencies: Genetic Risk Factorsfor Lymphoma A. H. Filipovich, A. Mathur, D. Kamat, and R. S. Shapiro ...... 5465s Familial Aggregation of Hematopoietic Malignancies and Risk of Hodgkin's Lymphoma Martha S. Linet and Linda M. Pottern ...... 5468s lmmunosuppressive Therapy and Immunological Disorders Leo Kinlen ...... 5474s Lymphoma Risks in Populations with Altered lmmunity--A Search for Mechanism Robert N. Hoover ...... 5477s Viruses Other than HIV and Non-Hodgkin's Lymphoma Nancy E. Mueller, Alejandro Mohar, and Alfred Evans ...... 5479s Epidemiological and Biological Study of Acquired lmmunodeficiency Syndrome-related Lymphoma in the County of Los Angeles: Preliminary Results Alexandra M. Levine, Darryl Shibata, Jane Sullivan-Halley, Bharat Nathwani, Russell Brynes, Marilyn L. Slovak, Suzanne Mahterian, C. Lynn Riley, Lawrence Weiss, Paul H. Levine, Suraiya Rasheed, and Leslie Bernstein ...... 5482s Pesticides and Non-Hodgkin's Lymphoma Shelia Hoar Zahm and Aaron Blair ...... 5485s Radiation and Non-Hodgkin's Lymphoma John D. Boice, Jr ...... 5489s Nutritional Factors and the Development of Non-Hodgkin's Lymphoma: A Review of the Evidence Scott Davis ...... 5492s Increasing Incidence of Non-Hodgkin's Lymphoma: Occupational and Environmental Factors Nell Pearce and Peter Bethwaite ...... 5496s Comments on Occupational and Environmental Factors in the Origin of Non-Hodgkin's Lymphoma Aaron Blair, Athena Linos, Patricia A. Stewart, Leon F. Burmeister, Robert Gibson, George Everett, Leonard Schuman, and Kenneth P. Cantor ...... 5501s Non-Hodgkin's Lymphoma and Occupational Exposure Paul A. Scherr, George B. Hutchison, and Richard S. Neiman ...... 5503s Prior Medication Use and Health History as Risk Factorsfor Non-Hodgkin's Lymphoma: Preliminary Results from a Case-Control Study in Los Angeles County Leslie Bernstein and Ronald K. Ross ...... 5510s Does Chronic Fatigue Syndrome Predispose to Non-Hodgkin's Lymphoma? Paul H. Levine, Daniel Peterson, Faye L. McNamee, Karen O'Brien, Gloria Gridley, Mary Hagerty, Jane Brady, Thomas Fears, Martin Atherton, and Robert Hoover ...... 5516s Discussion...... 5518s

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Part I11: Molecular and lmmunoregulatory Mechanisms

Pathogenetic Mechanisms in B-Cell Non-Hodgkin's Lymphomas in ttumans Michael Potter ...... 5522s Molecular Basis of Lymphomagenesis lan Magrath ...... 5529s Characterization of Chromosome I I Translocation Breakpoints at the bcl-I and PRADI Loci in Centroo'tir L)'mphoma Michael E. Williams, Sleven H. Swerdlow, Carol L. Rosenberg, and Andrew Arnold ...... 5541s A Measure ofGenomic InstabiliO' and Its Relevance to Lymphomagenesis Ilan R. Kitsch and Stanley Lipkowitz ...... 5545s Antigen Selection in Human Lymphomagenesis David W. Bahler, Andrew D. Zelenetz, Thomas T. Chen, and Ronald Levy ...... 5547s Epstein-Barr Virus-induced Human B-Cell Lymphomas in SCID Mice Reconstituted with Human Peripheral Blood Leukocytes Donald E. Mosier, Gast6n R. Picchio, Stephen M. Baird, Ryo Kobayashi, and Thomas J. Kipps ...... 5552s Follicular Dendritic Cells: B-Cell Proliferation and Maturation Andras K. Szakal and John G. Tew ...... 5554s The Past Is Prologue: The Use of Serum Banks in Cancer Research Alfred S. Evans and Nancy E. Mueller ...... 5557s Applications of Experimental Techniques to Epidemiological Studies of Non-Hodgkin 's Lymphoma: Use of Archival Tissues Paul H. Levine ...... 5561s Discussion ...... 5562s

Part IV: Summaries and Conclusions

Quantification of the Impact of Known Risk Factors on Time Trends in Non-Hodgkin's Lymphoma Incidence Patricia Hartge and Susan S. Devesa ...... 5566s Time Trends and Pathological Classification: A Summary G. Iris Obrams and Gregory O'Conor ...... 5570s Research Directions and General Discussion: A Summary Nancy E. Mueller and Joseph F. Fraumeni, Jr ...... 5571s Molecular and Immunoregulatory Mechanisms: A Summary Michael Potter ...... 5572s Conclusion~Perspective 1 Myron Essex ...... 5573s Conclusion~Perspective 11 Pelayo Correa ...... 5574s

October 15, Number 20

PERSPECTIVES IN CANCER RESEARCH 5647 Expression of Carcinoembryonic Antigen and Its Predicted 5713 Antitumor Effects of a Bispecific Antibody Targeting CA19-9 An- Immunoglobulin-like Domains in HeLa Cells for Epitope Analy- tigen and CD16. Irma Garcia de Palazzo, Michele Holmes, Cicek sis. Laura J. F. Heha. Fun-Shah Chen, Michael Ronk, Sybille GerceI-Taylor, and Louis M. Weiner. 5575 Aspirinand the Potential Role of Prostaglandins in Colon Cancer. L. Sauter, Virender Satin, Shinzo Oikawa, Hiroshi Nakazato, Lawrence J. Marnetl. Startle> Hefta, and John E. Shively. 5720 Synchronization of Breast Cancer Cell Proliferation in Vi~o by Combined Hormonal and Polyamine Manipulation. Andrea 5656 Reversalof Basic Fibroblast Growth Factor-mediated Autocrine Manni, Sonny Khin, Nell Biser, Hugh English, Betty Badger, Cell Transformation by Aromatic Anionic Compounds. Miriam Juliann Martel, and Laurence Demers. 5590 The Effect of an Amino Acid-lowering Diet on the Rate of Mel- Benezra, Israel VIodavsky, Avner Yayon. Rachel Bar-Shavit, phalan Entr3 into Brain and Xenotransplanted Glioma. Dennis R. John Regan, Michael Chang, and Shmuel Ben-Sasson. Groothuis, Bodo E. Lippitz, Istvan Fekete, Kurt E. Schlageter, 5725 Glycosylation Pathways in the Biosynthesis of Gangliosides in Melanoma and Neuroblastoma Cells: Relative GlycosyBrans- Peter Molnar, O. Michael Colvin, Charles R. Roe, Darell D. 5663 Immunization of Colorectal Cancer Patients with Modified Ovine Bigner. and Henry S. Friedman. ferase Levels Determine Ganglioside Panerns. Shutian Ruan and Submaxillary Gland Mucin and Adjuvants Induces lgM and IgG Kenneth O. Lloyd. Antibodies to Sialylated Tn. Kevin P. O'Boyle, Rochelle Zamore, 5597 Loss of the Metastatlc Phenolype by a Haman Epidermoid Car- Sucharita Adluri, Alfred Cohen, Nancy Kemeny, Sydney Welt, cinoma Cell Line, HEp-3, Is Accompanied by Increased Expres- Kenneth O. Lloyd, Herbert F. Oettgen, Lloyd J. Old, and Philip 5732 Incidence of c-Ki-ras Activation in N-Methyl-N-nitrosourea- sion of Tissue Inhibitor of Metalloproteinase 2. Jacqueline E. O. Livingston. induced Mammary Carcinomas in Pitaitary-isografted Mice. Testa. Raphael C. Guzman, Rebecca C. Osborn, Steven M. Swanson, Ramasamy Sakthivel, Soo-ln Hwang, Shigeki Miyamoto, and 5668 Scquence Specificityof Aflatoxin Ba-induced Mutations in a Pins- Satyabrata Nandi. 5604 Modulation of Protein Kinase C-~ by Phorbol Esters in the Mono- mid Replicated in Xeroderma Pigmentosum and DNA Repair Pro- blastoid U937 Cell. D. Kirk Ways, Berniece R. Messer, Trudy O. ficient Human Cells. Dan D. Levy, John D. Groopman, Susan E. 5738 FLT4 Receptor Tyrosine Kinase Contains Seven lmmunoglobalin- Garris. Weixi Qin, Paul P. Cook, and Peter J. Parker. Lim, Michael M. Seidman, and Kenneth H. Kraemer. like Loops and Is Expressed in Multiple Human Tissues and Cell 5610 AntUymphomaActivity of Human 78 T42ells in Mice with Sev- Lines. Katri Pajusola, Olga Aprelikova, Jaana Korhonen, Arja 5674 Sensitivity to Novel Platinum Compounds of Panels of Human ere Combined Immune Deficiency. Vera Malkovska, Francine K. Kaipainen, Liisa Pertovaara, Riitta Alitalo, and Karl Alitalo. Lung Cancer Cell Lines with Acquired and Inherent Resistance Cigek Nicholas Armstrong, Bart3 E. Storer, and Richard Hong. to Cisplatin. Peter R. Twentyman, Karen A. Wright, Prakash 5744 Stage-specific Expression of Cancer-associated Type 1 and Type Mistry, Lloyd R. Kelland, and Barry"A. Mutter. 5617 Genotoxicity of Environmental Agents in Human Mammary Ep- 2 Chain Polylactosamine Antigens in the Developing Pancreas ithelial Cells. Sandra R. EIdridge, Michael N. Gould, and Byron of Human Embryos. Xiao-Hui Tuo, Shigeyuki ltai, Junko E. Bunerworth. 5681 A Region of Antisense RNA from Human p120 eDNA with High Nishikata, Tohru Mori, Osamu Tanaka, and Reiji Kannagi. Homology to Mouse p120 eDNA Inhibits NIH 3T3 Proliferation. Benigno C. Valdez, Laszlo Perlaky, Yasuo Saijo, Dale Henning, 5752 Estrogen Receptor-directed Radiotoxicity with Auger ElecU'ons: 5622 DNA Strand Breaks and DNA Cross-Links in Peripheral Cihui Zhu, Rose K. Busch, Wei-Wei Zhang, and Harris Busch. Mononuciear Blood Cells of Ovarian Cancer Patients during Specificity and Mean Lethal Dose. Eugene R. DeSomhre, Babak Chemotherapy with Cyclophospbamide/Carboplatin. Jan Georg Shafii, Robert N. Hanson, Paola C. Kuivanen, and Alun Hughes. Hengstler, Juergen Fuchs, and Franz Oesch, 5687 Lethality, DNA AIkylation, and Cell Cycle Effects of Adoselesin (U-73975) on Rodent and Human Cells. B. K. Bhuyan, K. S, 5759 N-(4'-Hydroxypbenylacetyl)palytoxin:A Palytoxin Prodrog That Smith, E. G. Adams, G. L. Petzold, and J. P. McGovren. 5627 Proposed Role of Phosphatidic Acid in the Extracellular Control Can Be Activated by a Monoclonal Antibody-Penicillin G of the Transition from G2 Phase 1o Mitosis Exerted by Epidermal Amidase Conjugate. Gary S. Bignami, Peter D. Senter, Paul G. Growth Factor in A431 Cells. Marietta Kaszkin, James Richards, 5693 Antigen-specific Activity of Carcinoma-reactive BR64-Doxoro- Grothaus, Keith J. Fischer, Tom Humphreys, and Philip M. and Volker Kinzel, bicin Conjugates Evaluated in Vitro and in Human Tumor Wallace. XenograB Models. Pamela A. Trail, David Willner. Shirley J. Lasch, Arris J, Henderson, Robert S. Greenfield, Dalton King, 5635 Chemoprevention of Colon Carcinogenesis by the Synthetic Or- 5765 Perioperative lmmnnotherapy with Recombinant lnterleukin 2 in ganoselenium Compound 1,4-Phenylenebis(methylene)selenocy- Mary E. Zocckler, and Gary R. Braslawsky. Patients Undergoing Surgery for Colorectal Cancer. Paul H. anate. Bandaru S. Ruddy. Abraham Rivenson, Nalini Kulkarni, Nichols, Carol W. Ramsden, Ursula Ward, Peter C. Sedman, and Pramod Upadhyaya, and Karam EI-Bayoumy. 5701 Characterization of Tumor Cell Resistance to 4'-Deoxy-4'-iodo- John N. Primrose. doxorobicin Developed in Ehrlich Ascites Cells in Vi~o. Ellen 5641 Particular Types of Tumor Cells Have the Capacity to Convert Friche, Mar)' K. Danks, and William T. Beck. 5770 Cadberin Dysfunction in a Human Cancer Cell Line: Possible Transforming Growth Factor ~ from a Latent to an Active Form. Involvementof Loss of a-Catenin Expression in Reduced Cell-Cell Hidekazu Takiuchi, Tsuyoshi Tada, Xiao-Fei Li. Masato Ogata, 5707 Carotenoids Up-Regulate Coanexin43 Gene Expression Indepen- Adhesiveness.Yutaka Shlmoyama, Akira Nagafuchi, Shin Fojita, Tatehiko Ikeda, Shigeyoshi Fujimoto, Hiromi Fujiwara, and dent of Their Provitamin A or Antioxidant Properties. Li-Xin Masahiro Gotoh, Masatoshi Takeichi, Shoichiro Tsukita, and Toshiyuki Hamaoka. Zhang, Robert V. Cooney, and John S. Bertram. Setsuo Hirohashi.

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5775 Phase II Trial of Suramin in Patients with Advanced Renal Cell 5803 Inhibition of Cell Attachment b) Selenite. Lin Yan and Gerald D, 5826 Increased Inosine-5'-phosphate Dehydrogenase Gone Expression Carcinoma: Treatment Results, Pharmacokiuetics, and Tumor Frenkel. iu Solid Tumor Tissues and Tumor Cell Lines. F. R. Collart, C. B. Growth Factor Expression. Robert J. Motzer, David M. Nanus, Chubb, B, L, Mirkin, and E. Huberman. Paul O'Moore, Howard L Scher, Dean F+ Rajorin, Victor Router, William P, Tong, Jacqueiine lversen, Carl Louison, Anthon) P. Albino, and George J. Bosl. 5829 Antitumor Activity of the Type ! Plasminogen Activator Inhibitor and Cytotoxic Conjugate in Vitro. Jerzy Jankun.

5780 Absenre of HSP28 Syutbesis und Phosphorylation during lhe ADVANCES IN BRIEF 5833 Structure and Expression of Human FII-I Gone D. D. K. Prasad. Development of Chronic Thermotoleranee in Murine L929 Cells. Veena N. Rap, and E, Shyam P. Ruddy. Yong J, Lee, Zi-Zheng Hou, LindaLi Curetty. Michael J. Borre[li. and Peter M. Corry. 5808 Expression Level of the am23 Geue in Cioanl Populations of 5838 Pharmacokinetic Analysis of the Perivascular Dislribution of Bi- Metastatic Muriue and Human Neoplasms. Robert Radinsky, functional Antibodies and Haptens: Comparison with Exporimen- Herschel Z. Welshers. Alexander N, Staroselsky, and Isaiah J. tal Data. Laurence T. Baxter, Fan Yaan, and Rakesh K. lain. 5788 Genomic Rearrangements i, Mouse C3H/10T
89Cells Trans- Fidler. formed by X-Rays, UV-C. and 3-Methyleholanthrene, Detected by 5845 Tumm Cell Surface-associated Binding Site for the Mr 72,000 n DNA Fingerprint Assay. Benoit Paquette and John B. L/ttie. 5815 Fine-Scale [kletion Mapping ol the Distai Long Arm of Chromo- Type IV Cnllagenase. Herv~ P. Emonard, Albert G. Remaele, some 6 in 70 Human Ovarian Cancers, Susumu Saito, Hiroko Agn~s C. Noel, Jean-Alexis Grimaud, William G. Stetler- Saito, Sum/ko KoL Satoru Sagae, Ryuichi Kudo, Janko Saito, Stevenson, and Jean-Michel Foidart. Kiichiro Noda, and Yusuke Nakamura. 5794 Inhibitory Effect of 2-Deoxy-o-glucose on Liver Tumor Growth in Rats. O. Cay. M. RadnelL B. Jeppsson, B. Ahr~n, and S. Bengmark. 5818 Effective ,~-Panicle-mediated Radinimmunatherapy of Murine 5849 Announcements LeukemL~. Richard B. Huneke. C. Grog Pippin, Roberl A. Sqoire, Eighty-fourth Annual Meeting of the AACR Martin W. Brechbiel, Otto A. Gansow, and Motto Strand. New Format for Annual Meetings of the American Asso- ciation for Cancer Research Beginning in 1994 5797 Gene-sgecific Oligonucleotide Probes for a, .a, *, and Micro- AACR Special Conferences in Cancer Research somal Rat Glutatbione S4ransferases: Analysis of Liver Trans- 5821 Isolation of a Prostate Carcinoma Cell Proliferation-inhib/ting Calendar of Events (erase Expression and Its Modulation by Hepatic Enzyme luduc- Factor from Haman Seminal Plasma and Its Similarity to Trans- e~ und Platiunm Antie~ucer Drugs. David J. Waxman, Scott S. forming Growth Faclor ~. Balakrishna L. Lokeshwar and Norman Sundselh, Pramod K+ Sr~vaslava, and David P. Lapenson. L. Block 5852 Author Index

November 1, Number 21

5853 Distribution of ('ells Expressing myc Proteins in Human Coin- _g979 Differential Expression of ras Prm

5865 Do~+n-Regulution of Keratin 14 Gone Espression after v-t|a-ras 5985 E~pression of Tumor-ussociated Epital~s on Epstein-Burr Virus- ADVANCES IN BRIEF Transfection of iluman Papinomavirus-immortalizud ltuman immortalized RX'ells and Burkitt's 12,mphomas Trunsfected with Cerqcal Epithelial Cells, p. E. Bowden. (. [Z Woodwurth. Epithelial Nlucin Complementary DNA. Keith R. Jerome, Dawen 6083 The RCK Gene Associated vtith t( l l;14) TranMocation ls Distinet J. Donigcr, and J. A, DiPaolo. Bu. and t)ii~era J. Einn. from the MLL/ALL-I Cone with t(4;ll) and till;19)Translo- 5872 Cellular Transformation by a Unique Isolate of Iluman Papillw cations. Yukihiro Akao, Masao Scto, Knzuhito Yamamoto. mavirus T)pe 11. Ronald ('. McGlenncn, J)otsna Ghai. Ronald S 5q91 Presence of ras OncoRene Mutations and }luman Papillomnvirus Shinsukc lida, Shiopei Nakazawa. Johji lna~awa, Tatsuo Abe. ()~tro~. K~rt LaBte~h. John I=. SchncldeL uttd Anthoo~ 3. F~ras. DNA in Iluman Prostate Carcinomas. Khurshid Anwar, Kalu)a Toshitada Takahashi, and R)uzo t;eda, Nakakuki. Taizo Shiraishi. Iliron(Jhu Nalkl. Ryuichi Yatani. and 6088 Levels of am23 Messenger RNA in Metastatic Malignant Mela- 5879 A Comparison of the Abilities of NitrobeutyRhioim~sine. 1)ilazep, Manahu lnuzoka. nomas: Inverse Correlation to Disease Progre,~sion. Vivi Ann und Dipyridamole to Protect Human Hematopoietic ('ells from Fl~renes. Steinar Aamdal, Ola Myklebosl, Gunhild M. 7-Deazaadenosine (Tubercidin). Carol E. ('ass. Karen M. King, 5997 Errquent p53 Mumtions in Ilead and Neck Cancer. Kenneth D. Maelandsmo, Oyvind S. Bruland. and Oystcin Fodstad. Jcmct T. Monlano, and Anna Janowska-Wieczorck. Somers. M. Anne Mcrrick, Martha E. l,opez, Leonard S. Incognilo, (ia~ I.."k'hechter, and Graham Case). 6092 p53 Mutation and Protein ~ccumulation darim, Multistage lie- 5887 Epidermal Growth Factor Receptor Monoclona/Antibody Inhibits man Esaphagcal Careim~gene,ds, Willium P. Bennett, Monica C. Cnostitutire Receptor Phosphor)latiou, Reduces Anlnnomnus 6001 Human Placental ('ells Transformed ~ith Temperature-Sensitive Hollstein, Robert A, Metcalf. Judith A. Veelsh. A. He. Si rain Gro,ath, and Sensitizes Androgen-independent Prostatic ('arci- Simian Virus 40 Are Immortalized and Mimic the Phenotypr of Zha. Inca Kuslcrs, James It. Resau, Benjamin F. Frump, David noma Cells tu Tumor Necrosis Factor a. Chau-Jye Fong. Edward Invasive (')totrophoblasts at Both Permissive and Nonpermissive P. Lane, and ('urlis C. Harris. R. Sherwood. John Mcndelsohn. Chung Lee, and James M. Temperatures. Susan K. l,ogan. Susan J. Fisher. and Caroline H. Kozlowski, Damsky. 6098 Mutation of p53 Gone in Ilepatoccllular ('arcinoma in "l'aiwan, Jin-Chuan Shcu, Guan-Tarn Huang, Po-lluang Lee, Jui-Chen .r Decreased p~fJlycoprotein Expression in Multidrug-sensitive anti Chung, Huey-('hJ Ch*)u, Ming-Yang Lai, Jin-Town Wnng. -resistant Human Myelomn (ells Induced hy the C)takine I,eu- 6010 ZH-Nndear Magnetic Resonance ImaBing of Tumor Blood Flow: Hsoan-Shu Lee, Ling-Na Shih. Pei-Ming Yang. Teh-Hong koregulin. Charles H+ E~ans and Patricia 0, Baker. Spatial and Temporal Heterogeneity in u Tissur Mam- mary Adenocarcinoma. Clifford J. Eskey, Alan P. Koretsky, Wang, and I)ing-Shinn ('hen. 5900 Time Dep~ndeuceof DNA Lesious and Growth luhibilion h) ICI Michael M. Domach, and Rakesh K. lain. 610l Prognostic S,'alue of I.:rokinase-type Plasminol~en Activator in 671 DI694, a Ne~ Quinazoline Anti(plate Thymidylate Synthase In- Primar) Breast Cancer Patients. John A. Fockens, Manli'ed hibitor, Ming-bian Yin. Manoel A. (;uimaraes. Zheng-gang 6020 Fibrosarcomu Ceils Transduced with the IL-6 Gone Exhibit Re- Schmitt. Wire I,. J. ~an Putten, HarD' A. Peters. Marijke Zhang. Mark A. Arrcdondo, and Youcef M Rustum. duced Tumorigenicity. Increased Immnnogenicity, and Decreased Bonlenbal. Fritz Janlckc. and Jan G. M. Klijo. Metastatic Potential. Craig A. Mullen. Meiissa M~ ('oaie, Anna 5906 Modulation of Colonic Epithelial Ceil Proliferation. Ilistone T, Levy, William G, Stetlcr~Stc~cnson, I.ance A. Liotta, Stephen 6106 ImmunoRcnetic Influences on the Initiation .Stage of the ('utaue- Acet)lation, sad Luminal Short Chain Fair) Acids hy Variation of Brandt. and R. Michael Blaese. pus Chemical ('areinogenesis Pathv~a). Craig A. Elmets, S~ed Dicta D Fiber (Wheat Bran) in Bats. Lidia C. Boffa+ Joanne R. I. A~ Zaidi, David R. Bickers, and Hasan Mukhtar. [-upton, Maria R_ Mariani, Marcello Ceppi. Harold 1_. Newmaek, 6020 Fibrosarcoma Cells lransduced ~ith the IL-6 Gcne Exhibit Re- Alcssaodra Scaimati, and Martin Lipkin. duced Iumorig~niciD, Increased I mmunogenicit), and Decreased 6111) Detection of HemutoRenou~ Mierometasta~i~ in Patients with Prostate Cancer. Jo'~." G. Moreno. Carlo M. ('roce. Rainer 5913 The ]-Ceil Receptor V# Gone Usage in Tumor-infiltrating Lym- Metastatic Pmenlial. Craig A~ Mullen. Melissa M, Cl~alc, Anna Fischer, Maria Monoe. Pirkko Vihko, S. Grant Muihol/and. and phoc)te~ and Blond u( Patients with Itepatocellular Carcinoma. T. I,ev). ~ illiam G. Str Lance A. Liotta. Stephen Leonard G. (;omclla. Eckhart Weidmann. Theresa L. Whitcsidc, Roberto Giorda, Brandt, aud R Michael Blaese. Ronald B. Herbermam and Massimo Trucco. 6113 p53 Mutations in I"ormaldehyde-induced Nasal Squamous ('ell 6025 InhibitoD Effect nfSnmatostatin Anah~tue RC-16B on the Growth Carcinomas in Rats. I.eslie Recto, Susan Sisk, Linda Pluta, 5921 Cytotoxici~ of CD3-Ricin A Chain Immunotoxins in Relation to of Ilelmtie Nletostasos of Cnhm Cancer in Rats: A Stud) ~ith Edilberto Bermudcz. Elizabeth A. (;ross, Zhueho Chen, Kevin Cellular Uptake and Degradation Kinetics. Ypkc V. J. M. van Magnetic Resonance Imaging. Yunfcng Qin. Marc Van Caateren, Morgan. and ('her)l Walker. OosterhouL Frank ~. M. B. Preijers, Hans M. C. W'essels. and Michel Ostcaux, Andrew V Schall). and Gerard Willems. rhco de Witte. 6117 Nonlinkage of 16q Nlarkers In Familial Predisposition to V* liras" 6031 Gastrin Stimulates ('a 2 ~,,Iobilization and CIonal Growth 5926 Effects of 17$oEstradiol Metabolites on Cell (')~le Evenls in Tumor. Vicki Huff'. Anthony E. Reeve. Mark Leppert. Louise ('. in Small ('ell Lung Cancer ('ells. Tariq Scthi and Enrique Strong, Edwin ('. Douglass, Clementina F. Geiser, Frederick P. MCF-7 Cells. Mona-Liza Loitering, Marianne |fang, and Rozengurt. Li. Anna Meadows, David F. Callcn, Gilbert Lenoir, and Grady F. Johanna C. Scegers. Saundcrs. 5933 Phase I and Endocriue Study of Exemestane IFCE 24304k a Ne~ 6036 Targetedrherap) of Ath)mie Mice IkaringGW-3911umanCn- Aromatase Inhibitor. in Postmenopausal Womem T. R. ,lcffD ion/c Cancer Mierometasta sos t~ith ~-~ ~ 1-la br Monoclonal An- 6121 Haman Small ('ell I.ung Cuncer Expresse~ the Octamer I)NA- E~ans, Enrico Di Salle, Giorgio Ornati, Mercedcs Lassos, tihmlies. Rosal)n D. BlumenthaL Robert M. Sharked. Lcmuel binding and Nervous S)stem-specific Transcription Eactor N-Oct Margherita Strolin Benedetli, Elio Piancz~ola, and R. Charles Ha)wood. Ann M. Natalc. George Y. Wong, Jeffrey A. Siegel 3 (Brain-2). Edgar Schreiber. Andreas Himmelmann. Ursula Coombes. Stephen J. Kennel. and David M. Goldenberg. Malipiero, Andreas "lohler, Rolf Stahel, and Adriano Fontana.

5940 Phase I I Preclinical DraR ~%ereeniug iu Human Tumor Xenografts: 6125 Inherited WTI Mutation in Den)s-Drash S)ndromr Max J. 6045 Membraue Peroxidative Damage Enhancement b) the Ether A First European Multiceuter Collaborative Study. Epic Boron. Coppcs, Gcrril Jan Lie(ors, Mariko Higuchi, Arthur B. Zinn. Lipid Class of Anlineoplasfie Agents. Bruit A. Waguer. Garry R. Benlamin Winograd. Dietmar P. Burger, M. Patrick Dumoot, J. Williamson Balfc. and Bryan R G. Williams. 8no(trier. and C. Patrick Burns, Boudcwijn J. M. Braakhais, Oystein fodstad, Simon Langdon. and Hciner H. Fiebig. 6052 Identification of the ('rossd,ink between fiuman O*'-.'Methylgua- MEETING REPORT 5948 Identification of Immunogenic Human Melanoma Antigens in a nine-DNA Methyltransfera.ve and Chlornethylnitn)sourea-treated DNA. Pres~illa E+ Gonz~aga. Philip M. Potter, Tian-oi Niu. Dong 6129 ]he Role uf Cytnkines in the Regulation of Cell Eunetinn and in Polyvalent Melanoma Vaccine. Jean-('laude Bystryn, Milagros the Pathngenesis of I)iseaso: A Pathology A/Pathology B Study Ilenn. Joseph Li. and Susao Shroba. Yu. David B Ludlum, Joseph A~ RaBcrly, Geoffrey P. Margison. and Thomas P+ Brcnt+ ~a'tion 'r orkshop--$~,nrkiog Report from Ihe Division of Re- search Grants. Nationa! lostitutes of fteahh. Philip Farmat~ski. 59.r A Murine Model for Antibody-directed l'argeting of Vascular Eric G. Neilson. Jas~ant S. Bhorjee, and Martin Padarathsingh Endothelial Cells in Solid Tumors. Francis J. Burrows, Yoshihiko 6059 Interleukin 4 Receptor Expression and Growth Inhibition of Gas- Watanabc, and Philip E. Thorpe. tric Carcinomu ('ells b) Interleukin 4, Takashi Morisaki. Dale H. Yuzuki, Robert T. Lin. Lcland J. Foshag, Donald I-. Morion. and 6134 Anaonncements 5963 Receptors for Inlerleukin 2 on Human Squamous Cell Carcinoma Da~e S. B. Hoon. Eighty-Fourth Annual Meeting of the AACR Cell Lines and Tumor in Silo, Eekhart Weidmann. Manuela New Formal for Annual Meetings nf the AA('R Beginning Sacchi. Stephane Piaisaoce. Due Song Hen. Satoshi Yasumura. 6066 Magnetic Rc-s~nance Diffusbm ~maging Detects .Structural Dam- in ? 994 Wen-chang [in. Jonas T, Johnson. Ronald B, Herberman, Bruno age in Biological I issue~ upon I I)perthermia. Kwan Hon ('hung AA('R Special Conferences in Cancer Research Azzaronc. and Theresa L, Whiteside. and Marissa Hernandez. Recent Deaths ('alcndar of E~cnls 5971 Mucin Gone Expression in Colonic Tissues and Cell Lines, 6074 Somatostatin Reeeptor~ in Iluman Renal ('ell Carcinomas. S. Ogata, H. Uehara. A. Chcn, and S. H h,,kowitz. Jean-Claude Reabi and l.ar~ K~ols 6138 Author Index

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November 15, Number 22

6139 Expression of c-kit Receplor in Normal and Transformed lluman 6248 An Improved Fhalrometric Assa) flit Dosimetr) of Benzo(a)p.~- 6348 Intrinsic Radiosensitivity of Normal Human Fibrobinsts and Nonl)mphoid Tissues. Pier Giorgio Natali. Maria Rita Nicolra, rune i)ioI-Epoxide-DN A Adduets in Smokers" Lung: Comparisons Lymphocytes after High- and Lon-Dose-Rate Irradiation. Fady B. Irmi Surcs. Eugenio Santoro, AIdo Bigotti. and Axel Llllrich. nilh Total Bulk) Adduets and Ar)l tl)drocarbon H)drox~lase Geara, Lester J. Peters, K. Klan Ang, Jennifer L. Wike, Susan S. Aelisily. Kroum Alcxandro~, Margarita Rajas. Oli~ier Geneste, Sivon, Roland Guttenberger, David L. CalIender, Edmond P. 6144 Retinuid Stalus and the Control of Keratin Expression and Adhe- Marcel Castegnaro, Anne-Marie Camus, Stcfano Petruzzelli, Malaise, and William A. Brock. sion during the It istogenesis of Squamous Metaplasia of Tracheal Carlo Giunlini, and Helmut Bart~-h. Epithelium. Francesca Lancil[otti. Nadine Dar~iche, Giulia Celli. 6353 In Vivo Effects of High-lntensity UItrasound on Prostatic Adeno- and Luigi M. De Luca. 6254 Eradicatinn of llepatic Metastases of Carcinoma H-59 b) Com- carcinoma Dunning R3327. J. Y. Chapelon, J. Margonari, F. 6153 Mouse Monoclonal Antibodies ~*l*hich Recognize a Human bination Chemnimmanotberaps ~ilh I.iposomal Mnramyl Tri- Vernier. F. Garry, R. Ecochard. and A. Gelet. (BI-4)Galactosyltraosferase Associated ~ith Tumor in Body pcptide. 5-Fluorouracil. and l.eucolorin. Taka) uki Asao, ttenr~ R. 6358 p53 Gene Mutation Spectrum in Hepatocellular Carcinoma. Fluids. Morito Llemura, Takashi Sakaguchi, Takao Uejima. Shibata, Gerald Balisl. and Pnina Brodt. Tatsuya Oda. Hitoshi Tsuda, Aldo Scarpa. Michiie Sakamoto, Shiro Nozawa. and Hisashi Narimatso. 6258 Endogenous Tumor Necrosis Eactor Functions as a Resistant and Setsuo Hirohashi. 6158 ('omplementar) DNA Cloning for Galactos)ltransferase Associ- Factor against II.~perthermic (')toloxicit). Yasushi Tsuji. Naoki ated with Tumor and Determination of Antigenic Epitopes Recog- gatanabe, Tetsuro Okamoto, Naoki Tsuji, Hiroyoshi Sasaki, 6365 Effects of Differentiating Agents on Cell Surface Expression of the nized b) Specific 31onuelonal Antibodies. Takao Uejima. Morito Shinichiru Aki)ama. Naofumi ~ amauchi, and h oshiro Niitso, Breast Carcinoma-associated DF3-P Epitope. Lucian Perey, Ucmura, Shiro Nozawa. and Hisashi Narimatsu. Daniel F. Hayes, and Donald Kufe. 6263 Membrane Lipid Modification and Seositiqt) of I,eukemic Cells 6164 Responses to Retinoic Acid of Tamoxifen-sensitive and -resistant to the Thioelher Lipid Analogue BM 41.440. Eric S. Pelersen. Interstitial Hypertension in Human Breast and Colorectal Tu- Sublines of ttuman Breast Cancer Cell Line MCF-7. W. Barkle) Eric E. Kclle). Edward J. Modest, and C. Patrick Burns. mars. Joanna R. Less, Mitchell C. Pusher, Yves Boucher, Dennis Butler and Joseph A. Fontana. Borochovitz, Norman Wolmark, and Rakesh K. Jain. 6168 I ntralhecal 4-H ydroperoxye}clophosphamide: Neurotoxicit), Ccre- 6270 Polentialion of the Activity ol I-B-n-Arabinofuranosylc)tosine b'. brospinal Fluid Pharmacokinetics, and Antitumor AetiviD in a the Protein Kinase C Activator Bryostatin I in HI,-60 Cells: As- Rabbit Model of VX2 Leptomeningeal Carcinsmatosis. Peter C. sociation aith Enhanced Fragmentation of Mature DNA. Stesen Phillips, Thuy T, Than, Linda C. Cork, John Hilton. Benjamin S. Gram, V~. David Jar*is. Paul S. Sv.erdlo~. Am) J. Turner, ADVANCES IN BRIEF Carson, O. Michael Calvin, and Louise B. Grocho~, Rebecca S. Tra)lor, Hugh J. 'O;allace, Peck-Sun Lin. George R. Petiil. and David A. Gewiriz. 6175 Reduced Intracelluiar Drug Accumulation in the Absence of 6375 Binding of Human Single-Stranded DNA Binding Protein to P-Glycoprotein (mdrl) O~erexpression in Mitoxantrone-resistant 6279 Renal Cell Carcinoma and Natural Killer Cells: Studies in a Novel DNA Damaged by the Anticancer Drug cis-Diamminedichioro- Human MCF-7 Breast Cancer ('ells. Masayuki Nakagawa, Ral Model in Vitro and in Viva. Billic K. \t, inter, Shuo '~Vu. Alan platinum (11). Carol K. Clugston, Karen McLaughlin, Mark K. Erasmus Schneider, Kalharine H. Dixon. Julie Hurrah, Kristin C. Nelson. and S~.hia B. Pollack. Kenny, and Robert Brown, Kelley, Charles Morrow, and Kenneth H. Cowan. 6287 Prolonged Survival of Th)moma-beariog Mice afler Vacciuation 6380 The Immune Response to p53 in Breast Cancer Patients Is 6182 Colocalization of Basal and Luminal Cell-t)pe C)tokeratins in '~ilh u Soluble Proleio Antigen Entrapped in Liposomes: A Model Directed against lmmunedominant Epitopes Unrelated to the Human Prostate Cancer. Anja P. M. Verhagen, Frans C. S. Stud). Fan Zhou, Bard T. Rouse, and Leaf Huang. Mutational Hot Spot. Beata Schliehtholz, Yann Legros, Daniel Ramaekers, Tilly W. Aalders. H. Ewout Schaafsma, Frans M. J. Gillet, Claire Galliard, Michel Marly, David Lane, Fabieu Cairo, Debru)ne, and Jack A. Schalken. 6292 Tumors Arising in SCID Mice Share Enhanced Radiation Sensi- and Thierry Soossi. ti~ily of SCID Normal Tissues. ~*~,ilfricd Budach. Alan Hartford, 6188 Comparison of Cellular Accumulation and Cyloloxicit) of Cis- 6385 Structural Requirements of Simple Organic Cations for Recogni- platin ~ilh That of Tetraplalin and Amminedibutyratodichloro- Daniene Gioioso, Jill Freeman. Alphonse Taghian. and Herman D, Suit. lion b) Multidrog-resistant Cells, Marc Dellinger, Berton C. (c~,clohexylamine)platinum(IV) (JM221) in Human Ovarian Car- Pressman. Cesar Calderon-Higginson. Niramol Savaraj, Haim cinoma Cell Lines. Prakash Mistrj, Lloyd R. Kelland, Swee Y. Tapiero, Despina Kolonias, and Theodore J. Lampidis. l_oh, George Abel. Barry A, Murrer, and Ked R. Harrap. 6297 Chaoges io Growth and Tumorigenicity fnlloaing Recoostitution of Retinoblastoma Gene Function in Various Human Cancer Cell 6194 Mulalion Spectrum of the p53 Gene in Bone and Soft Tissue 6390 Mutations in the p53 Gene in Radiation-sensitive and -resistant Types b) Mierocell Transfer of Chromosome 13. Ashutosh Human Squamous Carcinoma Cells. Mira Jung, Vicente Notario, Sarcomas. Junya Toguehida, Toshikazu Yamaguchi. Bruce Banerjee. Hong-Ji Xu, Shi-Xue Hu, Diana Araujo, Rei and Analoly Dritsehilo. Ritchie. Roberta L. Beanchamp. Siri H. Dayton, Guillermo E. Takahashi. Eric J. Stanbridge, and William F. Benedict. Herrera, Takao Yamamuro, Yoshihiko Kotoura, Masao S. 6394 Induction of Sister Chromatid Exchanges by Extremely Los Sasaki. John B. Little, Ralph R. Weichselbaum, Kanji Ishizaki, 6305 Chrysotile Fiber Is a Strong Mutagen in Mammalian Cells. Tom Doses of a-Particles. Hatsumi Nagasawa and John B, Little. and David ~. YandelL K. Hei, Chang Q, Piao. Zhu Y. He, Diane Vannais, and Charles 6200 Effects of Genistein on the Growth and Cell Cycle Progression of A. Waldren. 6397 Accessibility to DNA in Carcinoma Chromatin Is Promoted hy Normal Human Lymphoc)tes and Human Leukemic MOI,T-4 Nanomolar Okadaic Acid: Effect on AT-Rich DNA Binding Pro- and HL-60 Cells. Frank Traganos, Barbara Ardeh, Nadine Haiku. 6310 Selectbe Inhibition of Tumor Cell Growth by a Recombinanl teins. Mary Strasberg Rieber and Manuel Rieber. Silvia Bruno, and Zbigniew Darzynkiewicz. Single-Chain Ant/body-Toxin Specific for the erbB-2 Receptor. Winfried Wels, lna-Maria Harwerth, Marcel Mueller, Bernd 6400 Carcinogen-specific Mulational Pattern in the p53 Gene in Ultra- 6209 pH in Human Tumor Xenografts and Transplanted Rat Tumors: Groner. and Nancy E. Hynes. violet B Radiation-induced Squamoos Cell Carcinomas of Mouse Effect of Insulin, Inorganic Phosphate, and m-lodobenzylguaoi- Skin. Stefan Kress, Christian Sutter, Paul T. Strickland, Hasan Mukhtar, Jiirgen Schweizer, and Michael Schwarz. dine. Eckhard J:ihde. Thomas Yolk, Anita Atema, Lou A. Smets, 6318 ldentificationofaNoveICD56 I,ymphokine-activatedKillerCell Karl-Heinz Glusenkamp, and Manfred F. Rajewsk~'. Precursor in Cancer Patients Receiving Recombinant Interleukin 6404 A Comparison of Human O6-Methylguanine-DNA Methyltrans- 2. R. Scott McKenzir Patricia E. Simms, Barbara A. Helfrich, ferase Promoter Activity in Met' and Met Cells. Linda C. Har- 6216 Intra- and Interindisidual Variabilily in Systemic Exposure in Richard I. Fisher, and Thomas M. Ellis. Humans to 2-Amino-3,8-dimelh) limidazo[4,~f]quinoxaline and ris, Philip M. Potter, Joanna S. Remack, and Thomas P. Brent. 2 -Amino- I -meth~ I-6-phenylimidazol4.5-blpyridine, Carcinogens 6323 Local Administration of Monuelonal Antibod) -Drug Conjugate: A Present in Cooked Beef. Amhony M. Lynch, Mark G. Knize, Alan 6407 Molecular Cloning of Rat Wilms' Tumor Complementary DNA Ne~ Strategy lo Reduce the Local Recurrence of Coloreetal Can- R. Boobis, Nigel J. Gooderham, Donald S. Davies, and Stephen and a Study of Messenger RNA Expression in the Urogenital Murray. cer. Kazuya Kitamara, Toshio Takahash/, Tatsuya Kotani. System and the Brain. Prem Mohini Sharma, Ximing Yang, Takuya Miyagaki, Nobuki Yamaoka, Hiroshi Tsurumi, Akinori Marianne Bowman, Veronica Roberts. and Saraswati Sukumar. 6224 CIonal Rearrangement of Chromosome Band 6p21 in the Mesen- Noguchi, and Toshiharu YamaguchL ch)mal Component of Pulmonar) Chondroid Humartoma. 6413 Differential Metabolic Patterns of lodinated versus Radiometal Jonathan A. Fletcher. Geraldine S. Pinkos, Kevin Donovan. 6329 Evidence That a Nmel Human Differentiation-inhibiting Protein Chelated Antiearcinoma Single-Chain Fv Molecules. Margaret E. Rizwan Naeem. David J. Sugarbaker, Stesen Menlzer. Jack L. Blocks the Dimethyl Sulfoxide-iodueed Differentiation of Eryth- Schott, Diane E. Milenic, Takashi Yokota, Marc Whitlow, James Pinkus, and Janina Longtine. roleukemia Cells by Inhibiting the Actisation of Membrane F. Wood. William A. Fordyce, Roberta C. Cheng, and Jeffrey Protein Kinase C. Jan P. Durkin, Bala Chakravarthy. Roger Schlom. 6229 Retroviral Vector-mediated Lymphokine Geue Transfer into Hu- Tremblay, Herve Jouishomme, James F. Whitfield, Jean-Michel man Renal Cancer Cells. Gueother Gastl, Connie L. Finstad. Biquard, and Valibor Krsmanovic. Anna Guarini. George Besl, Eli Gilboa, Nell H. Bander. and Bernd Gansbacher. 6335 Myelnpoiesis-associated lmmane Suppressor Cells in Mice Bear- 6418 Announcements 6237 Cylochrome P-450 3A4 (Nifedipine Oxidase) Is Responsible for log Metastalic Levtis Lung Carcinoma Tumors: "y Interferon plus Eighty-Fourth Annual Meeting of the AACR the C-oxidative Metabolism of I-Nitropyrene in Human Liver Tumor Necrosis Factor a S.vnergisticall.~ Reduces Immune Sup- New Format for Annual Meetings of the AACR Beginning Microsomal Samples. Kimberly J, Silvers, Tammy Chazinski, pressor and Tumor Growth-promoting Activities of Bone Marro~ in 1994 Michael E. McManus, Susan L. Bauer. Frank J. Gonzalez, HarD' Cells and Diminishes Tumor Recurrence and Metastasis. M. Rita AACR Special Conferences in Cancer Research V. Gelboin, Patrick Mantel and Paul C. Howard. I. Young and Mark A. Wright. Calendar of Events

6244 Elevated Uptake of Low Density Lipoproleins b) Human Lung 6341 Lipophilic Cisplatin Analogues Entrapped in Lipsomes: Role of 6421 Author Index Cancer Tissue in Viro. Sigurd Vitals, Curt Peterson, OIle lntraliposomal Drug Activation in Biological Activity. Roman Larsson, Peter Holm, and Bengt Aberg. Perez-Soler and Abdul R. Khokhar. 6422 Statement of Ownership, Management and Circulation

December 1, Number 23

6423 Inn'acellular Localization of Human DNA Repair Enzyme Meth- 6452 Effects of Cancer Immunotheropy with lndomethacin and Inter- 6487 Tumorigenic Suppression of a Human Cutaneous Sqanmous Cell ylguanine-DNA Methyltransferase by Antibodies and Its Impor- leukin-2 on Murine Hemopoletic Stem Cells. Mary Nel Saarloos, Carcinoma Cell Line in the Nude Mouse Skin Graft Assay. tance. Teck Choon Ayi, Kean Chang Loh, Rahmen B. All, and Nelson K. S. Khoo, and Peeyush K. Lala. Kathleen Conway, David Morgan, Karon K. Phillips, Stuart H. Benjamin F. L. Li, Yuspa, and Bernard E. Weissman.

6463 Tumor-associated M, 34,000 and M, 32,000 Membrane Glyco- 6496 A Retrovirm in Chinook Salmon (O~corhynckus tskawytscka) proteins That Are Serine Ph0spheq'lated Specif~allyin Bovine ~t~l Moa~lmal Andl~li~ to the M~0~enle Regeht0ff Protein with Plasmacyt0idLeukemia and Evidencefor the Etiologyof the MyoDI: Epitope Mapping and Dia4glnmstlc utnily. Peter Dins, Leukemia Vitl$-ind~ed L)amp~ Cells. Voko Aida, Disease. W. D. Eaton and M. L. Kent, David M. Parham, David N. Shapiro, Stephen J. Tapscott, and Kosuke Okada, M~hiro Ohtsuka, and Hi~shi Amanuma. Peter J. Houghton. 6501 Inhibition by ~-Fluorouraen of ci~-Diammincdichloroplatinum- Expression of the Endogenous Oe-Methylgoonine-DNA-methyl - (II)-induced DNA Interstrand Cross-Link Removal in a HST-I transferase Protects Chinese Hamster Ovary Cells from Sponta- Human Squamans Carcinoma Cell Line. Taito Esaki, Shuji 6440 Modulation of Subcellulat Dis~ibution of Doxorubicin in neous G:C to A:T Transitions. Gabriele Aquilina, Renato Biondo, Nakano, Takashi Tatsumoto, Mika Kuroki-Migita, Kenji Multidmg-resistani P388/ADR Mo~r Leukemia Cells by the Eugenia Dogliotti. Mark Mouth, and Margherita Bignami. Mitsugi, Minoru Nakamura, and Yoshiyuki Niho. Chemosensitizer { [2-1soprop)'bi-{ 4~3-N-methyl-N-(3,4-dimeth- T-Cell Subset AnalDis of Lewis Lung Carcinoma Tumor Rejec- oxy-~-phenethyl)amino]pr0pyl0x)" } Imu~.~d[myl } }ind0fim~. 6507 T~py with Unlabeled and t.~q-lal~lsl hn B.Cell M0n0d0ul Jean-Pierre Jaffr6zou. Thierry Levade, Pierre Chatelain, and Guy 6,Pl6 tion: Heterogeneity of Efft~'tors and Evidence for Negative Regu- Laurent. Antibodies in Nude Mice Bearing Raji Burkitt's Lymphoma latory Lymphocytes Co~elatlnu with Metastasis. Cohava GeIber, Xenonrafts. Donald J. B~hsbaum, Rich~d L. Wahl, Daniel P. Lea Eisenbach, Michael Feldman, and Robert S. Goodenow. Normolle, and Mark S, Kaminski. 6447 Inhibition of Cellular Proliferation by Peptide Analogues of Expression and CpG Methylation of the Insulin-like Growth Fac- Insulin-like Growth Factor I. Zbigniew Pietrzkowski, Dorothea Antitumar Effect of Interferon plus Cyclosporine A following Che- tor II Gone in Human Smooth Muscle Tumors. Ton Gloudemans, Wernicke, Pierluigi Porch, Bradford A. Jameson, and Renato motherapy for Disseminated Melanoma. Bishan S. Charak, Rita lna Pospiech. Leo T. M. Van Der Van, Cornelis J. M. Lips, Baserga, Marie Sadowski, and Amitabha Mazumder. H~l~ne Schneid, Willem Den Otter, and John S. Sussenbach.

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6522 Induction of c-los Gene Expression b) Exposure to a Static Mag- T-Cell Receptor # Chain Gene Rearrangement in Acute M.~eluid ADVANCES IN BRIEF netic Field iu IleLaS3 Cells. Masahiro Iliraoka, Junji Mi~akoshi, I,eukemia Alwa?,s Occurs at the Allele That Contains Ihe Under- Yu P. Li. Bokshil Shung, Hiraku Takebe, and Milsuyuki Abe. melh)lated Jill Region. Junko H. Oh)ashiki, Kazuma Oh)ashiki, Ken Kawakubo, Tetsu?o Tauchi. Shinpei Nakazawa, Nobuhiro 6690 Identification of the Eleventh Complementation Group of UV- Kimura, and Keisuke To)area, sensitive Excision Repair~lefective Rodent Mutants. Roberta 6525 I,uss of Jteteruzygosi~ Involves Multiple Tumor Suppressor Riboni, Elena Botta, Miria Stefanini, Masayuki Nunlata, and Genes in Iluman Esophageal Cancers, Ying Huaug. Robert F. Akira Yasui. 6603 Loss of Keratin Expression in Anaplastic ('arcinuma Cells Due tu Boynton. Patricia L. Blount, Richard J. Silverstein, Jing Yin, Yi Pusllranscriptional Down-Regulatiun Acting in trans. M. L. Tong, Timoth) K. McDaniel, Carnell Newkirk, James H. Resau, 6692 A New Functional Role for P-Glycoprotein: Effiux Pump for Paine, J. R. Gibbins, K. E. Che'~, A. Demetriou. and R. F. Rajeshwari Sridhara, Brian J. Reid, and Stephen J. Mehzer, Benzo(a)pyrene in Human Breast Cancer MCF-7 Cells. Grace Kefford. Chao Yeh, Joanna Lopaczynska, C, M. Poore, and James M. Phang. 6531 Pregnancy-dependent to Ovarian-independent Progression in Human Glucocorticoid Receptur Gene Deletion following Expo- Mammary Tumors Delineated in Primary Culture: Changes in sure to Cancer Chemotherapeutic Drugs and Chemical Mutageas. 6696 Freqocnt somatic Mutations of the APC Geue in Human Pancre- Signal Transduction, Growth Factor Regulation, and Matrix In- Lisa A. Palmer, Bharati Hukku, and Jeffre) M. ltarmon. atic Cancer. Akira Horii, Shuichi Nakatsuru, Yasuo Miyoshi, teraction. Waher lmagawa, Gautam K. Bandyopadhyay, Martha Shigetoshi Ichii, Hiroki Nagase, Hiroshi Ando, Akin Yanagisawa, Garcia` Akin Matsuzawa, and Satyabrata Nandi. Eiju Tsuchiya, Yo Kato, and Yusuke Nakamura. Phase I Cliuical and Pharmacological Study of Chlorequinoxaline Sulfonamide. James R. Rigas, ".AiUiam P. Tong. Mark G. 6699 Urinary Excretion uf O6-Butylguaniue after t he Administratiun of 6539 Estrogenic Potential of Progestias in Oral Contraceptives to Stim- Kris. John P. Orazem, Charles W. Young, and Raymond P. N-Nitroso-N-butylurea in Rats. Luisa Airoldi, Alessandro Gallk ulate Human Breast Cancer Cell Proliferation. Meei-Huey Jeng, Warrell, Jr. Cinzia Magagnotti, Renzo Bagnati, Marco Lolli, and Roberto Chrislopher J, Parker, and V, Craig Jordan. Fauelli. Transcriptional Repression of the neu Prutooncogene by Estro- gen Stimulated Estrogen Receptor. Kerr) Strong Russell and 6547 Mapping Chromosomal Breakpoinls of Barkitt's t(8;14) Translo- 6702 Antiangiogenic Agents Potentiate Cytotuxic Cancer Therapies Mien-Chic Hung. cations Far Upstream of c-mj'c. Stefan Joos, Frank G. Haluska, against Primary and Metastatic Disease. Beverly A. Teicher, Martin H. Falk, Berthold Henglein, Hors! Hameister, Carlo M. Enrique AIvarez Sotomayor, and Zhen Dong Huang. Croce, and Georg W. Bornkamm. Sensitivity of Resistaut Human Tumor Cell lanes to Tumor Ne- crosis Factor and Adriamycin Used in Combination: Correlation 6705 Analysis of a Metastasizing Testicular Mixed Gonadal Stromal bevaeen Down-Regulation of Tumor Necrosis Factur-Mossenger Tumor with Osteosareoma Compoueuts Suggests That a Malig- 6553 Angiugeuesis. Micruvascular Architecture, Microhemodynamies, RNA Induction and Overcoming Resistance. Jeffre~ Taylor Safrit nant Tumor with the Histology of Osteosarcoma May Develop and Interstitial Fluid Pressure during Early Growth of Human and Benjamin Bonaqda. without Primary Involvement of RBI and TP53. Peter T. W. Adenocarcinuma LSI74T in SCID Mice. Michael Leunig, Fan Reuvekamp, Rein P. Stulp, Heimen Schraffordt Koops, J. Woher Yuan. Michael D. Menger, Yves Boucher, AIwin E. Goetz, Oosterhuis, Hans Scheffer, and Charles H. C. M. Buys. Konrad Messmer, and Rakesh K. Jain. 6638 Polyethylene-Glycol-mediated Deliveo of Liposome-entrapped Pigments into Fibroblasts: Experimental Pigment Cells as Models 6708 Cellular Localization of the Folate Receptor: Potential Role in for Mutator Phenotypes. Stefan Schmitz. Theresa M. Allen, and Drug Tuxicity and Fulate Homeostasis. Steven D. Weitman, 6561 HLA Associatiun with Response and Toxicity in Melanoma Kowichi Jimbow. Arthur G. Weinberg. Leslie R. Coney, Vincent R, Zurawski, Patients Treated with Interleukin 2-based lmmanotherapy. Debra S, Jenuings, and Barton A. Kamen. Francesco M. Marincola, David Venzon, Donald White, Joshua T. Rubin, Michael T. Lotze, Toni B. Simouis, Jaikrishna Deletion of Chromosome llp13-11p15.5 Sk~luences in Invasive Balkissoon, Steven A. Rosenberg, and David R Parkinson, Human Ovarian Cancer Is a Subclonal Progression Factor. 6712 Cytuehrome P45011EI Genetic Polymorphisms, Racial Variation, B. Vandamme, W. Lissens, K. Amfo, P. De Sutter, C. Bourgain. and Lung Cancer Risk. Shunji Kato, Peter G. Shields, Nell E. E. Vamos. and J. De Gr6~e. Caporaso, Robert N. Hoover, Benjamin F, Trump, Haruhiko 6567 Comparison of Mouse and Human Colon Tumurs a ith Regard to Sugimara, Ainsley Weston, and Curtis C. Harris. Phase I and Phase I I Drug-metabolizing Enzyme S) stems. Liliane Massaad, Isabelle de Wazicrs, Vincent Ribrag. Frauqois JanoL 6653 Reductiun of Systemic Exposure and Toxicity of Cisplatin by En- Philippe H. Beaune. Jackic Morizet. Alain Gouyette. and Guy G. capsulation in Pol)-lactide-eo-glycolide. Ruud Verrijk, lngrid 6716 Evidence for the Involvement of a Potential Second Tumor Chabot. J. H. Smolders. Nel Bosnie, and Adrian C. Begg. Suppressor Gene on Chromosome 17 Distinct from p53 in Malignant Astrocytomas. Abha Saxena, W. Craig Clark, James Inhibitory Effect uf Green Tea on the Growth uf Estliblished Skin T. Robertson, Barbara Ikejiri, Edward H. Oldfield, and Iqbal 6576 Ex I, Tvo Differentiation Therapy as a Method of Leukemic ('ell Unnisa All. Purging in Muriue Bone Marrow Expansion Cultures. Marcus O. Papillomas in Mice. Zhi Y. gang. Mou-Tuan Huang, Chi-Tang Muench, Ziba Guy, and Malcolm A. S. Moore, Ho. Richard Chang, Wet Ma, Thomas Ferraru, Kenneth R. ReuhL Chung S, Yang. and Allan H. ConneL

6583 Potent Preventive Action of a-Carotene against Carcinogenesis: Spontaneous Liver Carcinogenesis and Promoting Stage of Lung Effect of Buthionine Sulfuximlne and Ethacrynic Acid on Cyto- and Skin Carcinogenesis in Mice Are Suppressed More Effec- toxic Activity uf Mitomycin C Analogues BMY 25282 and BMY tisel) b~ a-Carotene Than by B-Carotene. Michiaki Murakoshi, 25067. Bing H. Xu and Shivendra V. Singh, 6722 Announcements Hoyoku Nishino, Yoshiko Satomi, Junko Takayasu, Teiku Eighty-Fourth Annual Meeting of the AACR Hasegawa, Harukuni Tokuda. Akin Iwashima, Junichi Okuzumi, 6671 Elev~ed Expression of the Ornithiue Decarboxylase Gene in Hu- New Format for Annual Meetings of the AACR Beginning Hidetoshi Okabe, Hirokazu Kitano, and Ryuzo Iwasaki. man Esophageal Cancer. Masami Yoshida, Haruyuki HayashL Masanori Taira, and Kaichi Isono. in 1994 AACR Special Conferences in Cancer Research 6588 Frequent p53 Gene Mutations in Blast Crisis of Chronic Myelug- Recent Deaths enuus Leukemia, Especiall) in M~.eloid Crisis Harboring Loss of 6676 Qucrcetin Arrests Human Leukemic T-Cells in Late G I Phase of Calendar of Events a Chromosome 17p. Hiroyuki Nakai, Shinichi Misawa, Junya the Cell Cycle. Mitsunori Yoshida, Masuji Yamamoto, and Toguchida` David W. Yandell, and Kanji lshiraki. Toshiu Nikaido. 6725 Employment Register uf the AACR 6594 Clonal Analysis of Human Breast Cancer by Means uf the 6682 Fibroblasts Transformed b.~ Differeut ras Oncogenes Show Dis- Polymerase Chain Reaction. Shinzaburo Noguchi, Kazuyoshi similar Patterns of Protease Gene Expression and Regulation. Motomara, Hideu Inaji, Shingi Imauka` and Hiroki Koyama. Jian-Yi Zbang and Richard M. Schuhz. 6733 Author Index

December 15. Number 24

6790 Modulation of Cisplatin Resistance in Human Malignant Mela- 6848 Tamoxifen Stimulates Human Papillomavirus Type 16 Gene Ex- SPECIAL LECTURE noma Cells. Edward F. McCiay, Kathlcen D. Albright, Jeffrey A. pression and Cell Proliferation in a Cervical Cancer Cell Line. Jones, Alan Eastman, Randolph Christen, and Stephen B. Jin-Yun Hwang, Bi-Yu Lin, Fen-Met Tang, and Winston C. Y. Howell. Yu. 6735 Human Gastric Carcinogenesis: A Multistep and Multifactorial Prueess--First American Cancer Society Award Lecture on Can- 6853 Overexpression of Metaliothinuein in Chinese Hamster Ovary cer Epidemiulogy and Prevention. Peiayo Correa. 6797 Resistance of Marine Lung Tumors to Xenobiotic-indnced Cyto- Cells and Its Effect on Nitrogen Mustard-induced Cytotuxicity: toxicity. P. Gek Forkert, Andrew Parkinson, Larry G. Thaete, and Role of Gene-specific Damage and Repair. Karsten Wassermann, Alvin M. Malkinson. Mirosiav Pir~el, and Vilhelm A. Bohr. 6741 Down-Rogulation of c-MYC Antigen Expression in Lymphocytes 6860 Identification of a Protein Factor Secreted by 3T3-LI Preadipo- of Eu-c-myc Transgenic Mice Treated with Anti-c-rove DNA Me- 6804 Ailelic Loss from Chromosome 11 in Parathyroid Tumors. Eitan cytes Inhibitory for the Human MCF-7 Breast Cancer Cell Line. thylphasphonates. Eric Wiekstrnm, Thomas A. Bacon, and Erica Friedman, Luiz De Marco, Pablo V. Gejman, Jeffrey A. Norton, Patrick G. Johnston, Christina M. Rondinoue, Donna Voeller, L. Wickstrnm. Allen E. Bale, Gerald D. Aurbach, Allen M. Spiegel, and Stephen and Carmen J. Allegro. J. Marx. 6746 Phase I and Pbarmacokiuetie Study uf the Novel Platinum 6866 lanbiUty of Leocovorin to Rescue a Naturally Methotrexate-resis- Analogue CI-9'73 on a 5-Daily Dose Schedule. Peter J. O'Dwyer, 6810 Clonal Growth of Hepatitis B Virus-integrated Hep~ttocytes in taut Human Soft Tissue Sarcoma Cell Line from Trimetrexate Gary R. Hudes, Judy Walczak, Russell Schilder, Frank LaCreta, Cirrhotic Liver Nodules. Hideaki Yasui, Okio Hino, Keiko Cytotoxicity. Wet-Wet Li and Joseph R. Bertinu. Barbara Rogers, Ira Cohen, Charles Kowal, Lloyd Whitfield, and Ohtake, Rikuo Machinami, and Tomoyuki Kitagawa. Rebecca A. Boy& 6871 Developmental Regulation of Aanexin I1 (Lipocortin 2) in Human 6815 Lower Heat Shock Factor Activation and Binding and Faster Rate Brain and Expression in High Grade Glioma. Steven A. Reeves, 6754 Invasion of Connective Tissue by Human Carcinoma Cell Lines: of HSP-70A Messenger RNA Turnover in Heat Sensitive Human Cindy Chavez-Kappel, Richard Davis, Mark Rosenblum, and Requirement for Urokianse, Urokinase Receptor, and Interstitial Leukemias. Nahid F. Mivechi, Honghai Ouyang. and George M. Mark A. Israel. Collageanse. Liliana Ossowski. Hahn. 6877 Regulation of Smooth Muscle a-Actin Promoter in ras-trans- 6761 Biological and Immunological Features of Humanized MI95 formed Cells: Usefulness for Setting Up Reporter Gen~based (Anti42'D33) Munoclonal Antibodies. Philip C. Caron. Man Sung 6823 Histogenetic Analysis of Ovarian Germ Cell Tumors by DNA Assay System for Dru n Screening. C. Chandra Kumar, Pierre Co, Marcia K. Bull, Nevenka M. Avd~lovic. Cary Queen, and Fingerprinting. Masaki Inoue, Masami Fujita~ Chihiro AzUma. BusOel, Sheela Mohan Petersola, and Ferrlando Ramirez. David A. Scheinberg. Fumitaka Sail, and Osamu Tanizawa. 6885 Relationship of Cellular GlutathJone to the Cytotoxicity and Re- 6768 High Molecular Weight Transforming Growth Factor ~' ls Ex- 6827 Effects of Ketocoanzole on the Proliferation and Cell Cycle sistance of Seven Platinum Compounds. Coby Meijec, Nanno creted in the Urine in Active Nodular Sclerosing Hodgkin's Dis- of Human Cancer Cell Lines. Marie-Elisabeth Forgue-Lafitte, H. Mulder, Hetty Timmer-Bosscha, Wire J. Sluiter, Gert Jan ease. Samuel R. Newcom and Krishna K. Tagra. Anue-Marie Coodray, Dominique Fagot, and Jan Mester. Meersma, and Elisabeth G. E. de Vries.

6774 Pharmcokinetics and Therapeutics 0f Sterically Stabilized Lipo- 6832 IR Vitro C.vtot0xic Targeting by Human .M0mNdear Cdls tad 6890 Inhibitionof 12-0-Tetradecanoylph0rboM3-acetate-causedTu- somes in Mice Bearing ('-26 Colon Carcinoma. Shi Kun Huang, Rispecific Antibody 2BI, Recognizing c-erbEb2 Protooecngene mor Promotion in 7A2-Dimethylbenz[alanthracene-initiared Erle Mayhew, Syed GilanL Danilo D. Laslc. Frank J. Martin, and Product and Fc'y Reoeptor III. Sylvia T. Hsieh-Ma. Audrey M. SENC'AR Mouse Skin by a Polyphenolic FraCtion Isolated from I)emetrios papahadjopoulos. Eaton, Tim Shi, and David B. Ring. Green Tea. ~antosh K. Katiyar, Rajesh Agarwal, Gary S. Wood, and Hasan Mukhtar. 6782 ~-Difluoromethylornithine Alters Calcium Signaling in Platelet- 6840 Isolation and Characterization of a Highly Malignant Variant of derived Growth Factor-stimulated AI72 Brain Tumor Cells in the SW480 Human Colon Cancer Cell Line. Naohiru Tomita, Wet 6898 Association of Bovine Papillomavirus Type 2 and Bracken Fern Culture. Burt G. Feuerstein, Jlknos Szoll6si, Hirak S. Basu, and Jiang, Hanina Hibshoosh, Dorothy Warburton, Scott M, Kahn, with Bladder Cancer in CuRie. M. Saveria Campo, William F. H. Laurence J. Morton. and [. Bernard Weinstein. Jarrett, Run Bah'on, Brian W. O'Neil, and Kenneth T. Smith. Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. CONTENTS OF VOLUME 52

6~ NovelExpmsiou ol Guuriu (Cbok,cystokim-B) IbeX0. 6945 Comisgml Dbroptio~ 0fine AMLJ ~ Oco=rs witbia 9Single 6969 Expressien aM Functiomd Activity of P-Glye0pr0tein in Cultored ~=~,.t,~--b=he~dt~t Ptm~ Cmlnom:R~ Detemb Inl~ in tk 1(&21) Ch~em~ Trta~e~. Kimik0 CtlrebraJ Capilh=ry Endothelial Cells. Erik J, Hegmann, H. C. ~ a~l Cl~mrmct(~Izml~n. Weigong Zhou, Stephen p. Povoski. Shimiz~t+ Hiroyuki Miyo~hi. Tomoko Kozu. Jtmko NagaeL Rauer, and Ro~rt S, Kef0d. Daniel S, Lortgr~ker. and Richard i~[, Bell, Jr. Keii~hiro Enomoto. Nol~t~ Maseki. Ya~uhiko Kerteko. and Misa00hki. 69"/6 A F,~ Screen fmrGer~ Llae~$JMutatlons Ba~tl o, Tra~n- 6912 M=Idtti~ 0fc.jn ~ljla-B Mmetl~ P.NAml idil~lm of scriptiomd AetiyJt~. T~ien'y F~bom'g, N0ele Bexbicr, Jaynr IDNA Synthesh by Pl~n~Sbtndi~ E~ in Syri=m I-[ll~tt-r Embryo Karl, YinoShan Ng, Pel;SY Romero, and Stephen H. Friend. (~|l~, Matthew S. Cowlen =*rid Thorr~s E. Eling. 6949 Imu~mmoh~tod~emk~ Stai~lQ 9foe Tr,m~lfOtelmtm~ Growth F~cto~r #, A~t.te. wlth ~se=s~ Pr,=.~.~,~a.,,mi;,,, Hum=aR,~t C=ecer. 69"79 L~erk of T~eH ll~mu~il~ in ~l~r w~b ~ex~t~l~ A~ti-Moo~ S(r M, Gomh,Vincenl A. Memoli,Tl~sr A. ~tukc~~-s)~r cb~eExpl~sla I the CarcinoembryonicAntigen C,eue ta 9Noahla- I. Gold. and ~radk-y A, Attn. ,nd ~.ll~n F. LoBu~li0. man P~mat.. J. Kaotor, K. |rvine. S. Abrams. P. Sttoy. R. Olsen, J. Grr H. Kaufman, D. ESgensl~rger, and J. S~h|om. Disruption of Mitocho~r~d Fttgtctlo~ by Sttn~min M~sl~l by gbO~ 123 RelenOmml Ox)leu c=~=w~ +, mu~ LETI'ER TO THE EDI[TOR 6926 Pogent gud Sl~r162 Inhibition of 1=60"~ IPre~,4n ~ t~ Vi~ it~ im P'it~ by R.adk*k~. Ho Jeon 8 Kwon. Minoru Yoshida. Yasuhisa Fokui, Sueharu Horinotwhi. and Teruhiko Br~. and George Wildin$. 6983 Coeresl~mde,cere: S. M. Brom~ei=~~t aL Emcie~tIRe==~ of O~- ]gthylg~mnlne,~at not O'-Eth~tt~ymme or OZ-Etbyttt=ym~ne,is ~. Deptqldtnt lll~ (?S-A|kyllWanine'-DNA A|kyltya~sferase and C~,tl, ~ Mditml by Tnt~f~ 0f p53 i. N=de~le ExcisionReI~ Activitiesiu H.=~ Cells.Cm'. 6931 Card=ml~nldt3~ Studies of Fl~>xett~ Hy~'e~lm'k~ tn Ra~ tad Hm292DM Hmmm Lm~ C==r162 Cells Exlwe~=lr Eaek~t~ ]~+ 52: 200S-:mlt, tg~Z. Victor g. CmldmK~r. Reply by S. Mite. R~ymond A. Se~dele. Elizabeth R. Adams. Wherly P. ou~ Wild.Type p~3 Pro~in+ Jeatt-F~-~o~s CajoI, Michae) J. Maynard Bronstein, Thomas R. Skopek, and James A. Swenberg. Hoffman, Christian L. Grie~ and Douglas M. Morton_ Ander~3n. Teresa A. Lehman. H~rls Shapiro. Aticia A. ~r;4~g~. and EricJ, Stanbfidge. 6986 Alaaeo~-emer ADVANCES IN BRIEF 6961 Exl~'essionud Rqpdatioe of tl~ Leukemia Inhibitory Factor/ Eight~-Founh Annual Meetingof the AACR D Ftct0f Geae |~ Haman T-Celt Leukemia Virus Type I Infected New Formatfor Annual Meetingsof tb.eAACR Beginning T,Cdl ~ T0m0~0 Umemi~-Obd~ T~i~J ~,tm~, in 1994 Met=bolbtm by Dk-mmtreL Daniel L. Gus~ffson and Chris A. ~CR S~ial Conferena~i. C~=r a.c=r=~ Pfitsos. yoshiuo&m Nakao. Calendar of Events

ASsor with ~ of Ail~lro~le~t ~ro~gltte 6989 Ada0~Idl~ at to ~e~=rs Career, Timothy J. McDonnell. Pgtri,~ Tronr Sha~wn M. H~t~ e~t C= N~-,,am Mmmm-y Epltltel~ Ce~L Pen~ B~Y, C[Ir~t0plter LogothetL~Lr w, K. Chun8,J~-T~ Liang, Lidla A~r Khm~dml Keyo~i. Ruth S~ger, l~nd Arthur B, Pardr162 H~h, Shi-MinllT~, tmi Mm'tinL Campbell.

Cover Illustrations for Volume52 Jiinuil~ 1: Her Imperial Highness, Pnncess TaXamatsu, of duly 1; J. Michael McGinnis, Director of the Office of Disease the Royal Family of Japan, founder of the Princ~S Taka- Prevention ~ Health Promotion, Unitecl States Depart- matsu (~aRoer Research Fund. rnent of Health and Human Services, with the covers Of several recent key publications of the Department of Health January 15: Logo for the Second Joint Meeting of the Amer- and Human Services. ican Association for Cancer Research and the Japanese Cancer Association, Honolulu, Hawaii, February 10-14, July 15: Charles S. Lieber, Helmut Kad Seitz, and Albert 1992. Tuyns, researchers working on defining the links between consumption of alcoholic beverages and cancer. February 1: Hans-Gunter Neumann, Ruggero Montesano, Steven R. Tannenbeum, and Miriam C. Poiher, with the August 1: A depiction of the accumulation of cyclins during structure of 4-aminobiphenyl~emoglobin adducts and a the cell cycle and their abrupt destruction at mitosis. ~l'~0h glOW~ the reationship between the aclduct level of r~og~b~n and sn~kino ~lU~l~. Al~gllt 15; Steven A, R0sen~rg, Chief of Surgery, National February 15: Bemadine P. Mealy, Director ot the National Cancer Institute, developer of t~nlqu~ t0 wid~ the appiiC~Dility of tumor-infiltrating lymphooytes to cencer Institutes of Health. treatment. Mlr 1: Slmuel Brown, JP., CaromReed Ash, C. Michael ~ber 1: Lawrence F. Einhom, Brian MacMahon, and Brooks, and John L. Currle. th(~ O~fg of t~ Association for Cancer Education. Ch~stlaneNu~10in.V01hard, reci~ents of the 1992 General Motors Cancer Research Foundation awards. March 15: A depiction of a DNA chain to highlight the work of the Human Genome Project, coordinated by James September 15: Wilfred D. Stein, with graphs illustrating W~lt,~n, heacl 0f the National Center for Human Genome growth models for bladder cancer, multiple myeloma, and S|onlacl3 cancer and the effect of smoking cessation on Research. lung cancer risk. April 1: Gianni Bonadonna, Louis Sullivan, and T. C. Hsu, re~l~M~t~ Of ~ 1001 Am~ Cancer ~ Meom 0f Ooto41~r 1; E. L. Kennawau and J. W. Cook, investigators Hol~or. who ~d I~c~z0(a)0yreneas the ~r0n0gen o, major potency in coal tar. ~=r. Is: Ch=~esM. gauoh, C. L. Krumdi~'x,arid Ma0~van G. Nair, with a depiction of the structure of an antifolate is: R~hard J O'floilly. Pr~ident, Cleon T, K~0p, pOly-7-91utamate. Chairman of the Board. and Rebecca R. Kry, Executive Director, of the Cancer Research Fund of the Damon May 1: June L. Biedler, Michael M. Gottesman, 611zabe~ J. ~uw~W~ Wimt~l F0unclat~, ancl Damon Runyon Robert~n, Pelayo Correa, and Susan Band Horwitz, win- with Walter WinOhell. nets of the 1992 scientific awards of the American Associ- ation for Cancer Research. November 1: George F. Vande Woude, Editor-in-Chief of Ce// Growth & Differentiation, the molecular biology journal of May 1w Thomas A. Waldmann, recipient of the 1992 Bristol- the American Association for Cancer Research. Myers Squibb Award for Distinguished Achievement in Cancer Research. November 15: Lee W. Wattenberg, 1992-1993 President of the American Association for Cancer Research. June 1: Cover of Diet, Life-style and Mortality in China, a monograp~ by Chen Junshi, T. Colin Campbell, Li Junyao, December 1: Lloyd W. Law, pioneering researcher in the field RiCt~Cl Pet0 cletallirg;jsome of the findings of a series of carcinogenesis, whose work led to the development of of Dm'tioulady large studies of the effects ott environment the L1210 ~1 line. and be~av~ on mortality rates in China. Dweml0~r 15: Theodore S. Hauschka, eady investigator into June 15: Judah Folkman, winner of the 1992 Wolf Award in the cytogenetics and immunogenetics of cancer who de- meclicine and the 3M Life Sciences Award from the Fecler- fined cytogenetic parameters in cancer and developmental s,~ ot Ae~i~n ~ for Expenmental Biology. disorders in mice and humans.

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Cancer Res 1992;52:6999-7074.

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