DOCSLIB.ORG

Journal Video News Education

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Journal Video News Education Journal Video News Education ecancer.org is a free online platform for oncology Statistics since launch in 2007 professionals incorporating an open-access journal, news, video and education. 3.5 million visitors 183 international 11 million video from 196 countries conferences filmed views Nurses Other Medical Radiation Oncologists Professionals 1 2 3 4 5 - 6 Surgeons Who we are Statistics since Editorial Board Journal News Abstracts Industry launch and Scope 7 - 8 9 10 12 13 Medical Oncologists ecancer.tv Education Latin American ecancerpatient Supporters Research Scientists Edition 14,000 members Journal Video News Education Twitter Facebook LinkedIn iTunes U 8,000 1,600 6,200 23,000 1 *figures correct as of January 2016 2 Editorial Board “The journal has gone from strength to strength, it has become a platform which I consider to be Professor Claudio Basilico ecancermedicalscience is the open access cancer Pay what you can afford publishing model a first choice for submitting my NYU School of Medicine, New York, USA journal of the European Institute of Oncology, publications. The advantages of Milan (IEO) and the Organisation of European It’s been two years since we launched our ecancer include the very efficient, Professor Pier Paolo Di Fiore Cancer Institutes (OECI). pioneering “Pay what you can afford” publishing personal service, the wide variety of European Institute of Oncology, Milan, Italy model and so far it’s been a great success. We articles which are published and the Journal facts and figures ask authors who have received funding which is Professor Alexander Eggermont specifically provided for open access publication fact that they are shared so widely Institut Gustave Roussy, Paris, France • No article processing charge for those without (mandated by many governments and funders) to with a truly international focus.” funding pay towards an Article Processing Charge (APC) Dr Rachel Iredale, Director of Cancer Support, Professor Aaron Goldhirsch • No subscription charges upon acceptance after peer review. In this way we European Institute of Oncology, Milan, Italy Tenovus Cancer Care, and Reader in Public • Publication in two months ensure that authors with no funding are partially Engagement, University of South Wales • Rejection rate 50% supported by those who can afford to pay an APC. Professor Gordon McVie, Managing • Submissions accepted in English, Spanish and Editor Portuguese This publishing model is now being adopted European Institute of Oncology, Milan, Italy • Articles viewed 50,000 times a month by other publishers, evidence that where Special issues Professor Roberto Orecchia ecancermedicalscience innovates, others follow. University of Milan and European Institute of Oncology, It allies perfectly with our mission of breaking A minimum of four special issues a year are Milan, Italy Indexed in PubMed, PubMed Central, Scopus, down financial, geographic and linguistic barriers published in ecancermedicalscience on hot topics Embase, EBSCO and Google Scholar and to cancer communication. As a not-for-profit in a wide range of subject areas. We publish in Professor Pier Giuseppe Pelicci included in the core collection of Web of Science organisation, we make sure that all the funding we multiple languages wherever possible – recent European Institute of Oncology, Milan, Italy receive is re-invested in the community we serve. special issues include Cervical cancer prevention in Latin America (available in Spanish and English) Professor Richard Sullivan and Biomarkers, screening and prevention in Council for Emerging National Security Affairs and Kings The Founding Editors are highly respected and cancer. Upcoming topics to be reported on include College, London, UK authoritative leaders each representing a Novel technologies in breast cancer surgery and different field of cancer research. Pharmacoeconomics. Professor Umberto Veronesi, Founding Editor If you have any suggestions for potential special European Institute of Oncology, Milan, Italy Professor Gordon McVie issues, or are interested in becoming a guest editor is the Managing Editor of or author, please contact our scientific editor, Dr Professor Giuseppe Viale ecancermedicalscience. He is Linda Cairns at [email protected] University of Milan and European Institute of Oncology, widely regarded as a leading Milan, Italy international authority in the research and treatment of Views of ecancermedicalscience articles on PubMed Central Professor Luis Pinillos-Ashton cancer, having been CEO of Cancer Research National Cancer Institute of Peru (INEN), Lima, Peru UK. He is Visiting Professor in Cancer Studies at Kings College London and the University of Maria S Pombo-de-Oliveira Extra author services Research Center of Instituto Nacional de Câncer (INCA), Milan where he also advises the FIRC Institute Rio di Janeiro, Brazil of Molecular Oncology. We provide a free language editing service to all our authors, as well as free translation of Spanish and Professor Rajiv Sarin Portuguese articles. All ecancermedicalscience Advanced Centre for Treatment Research and Education Professor Umberto Veronesi articles have Article Level Metrics, so authors are over 2000 authors have in Cancer (ACTREC), Tata Memorial Centre, Mumbai, is the Founding Editor of able to monitor the impact of their articles and India published for free ecancermedicalscience. access statistics on how many people have read He is the Founder and their work in a variety of international repositories, Professor Cornelis J H van de Velde Emeritus Director of the Leiden University Medical Center, The Netherlands social media and online reference managers. European Institute of Oncology, Milan and is the pioneer of breast- conserving surgery. 533 articles from 57 countries 3 4 Abstracts Conference Report Clinical Study Special Issue Highlights from the 14th St Gallen Repurposing Drugs in Oncology (ReDO)— Barriers to preventive therapy for breast The following is a small selection of International Breast Cancer Conference nitroglycerin as an anti-cancer agent and other major cancers and strategies to ecancermedicalscience abstracts, all of these articles appear in PubMed Central and are freely available to 2015 in Vienna: Dealing with classification, improve uptake Vidula Sukhatme1, Gauthier Bouche2, Lydie Meheus2, view online. prognostication, and prediction refinement 1, 3 2, 4 Vikas P Sukhatme , Pan Pantziarka Andrea DeCensi1, 2, Mangesh A Thorat2, 3, Bernardo to personalize the treatment of patients with 1 GlobalCures, Inc, Newton MA 02459, USA Bonanni4, Samuel G Smith2, 5 and Jack Cuzick2 2 early breast cancer Anticancer Fund, Brussels, 1853 Strombeek-Bever, 1Division of Medical Oncology, E.O. Ospedali Galliera, Belgium Mura delle Cappuccine 14, Genoa 16128, Italy 3 Review Angela Esposito, Carmen Criscitiello and Giuseppe Beth Israel Deaconess Medical Center and Harvard 2Centre for Cancer Prevention, Wolfson Institute of The challenge of cancer in middle-income Curigliano Medical School, Boston, MA 02215, USA Preventive Medicine, Queen Mary University of London, 4 countries with an ageing population: Mexico Division of Experimental Cancer Medicine, Division The George Pantziarka TP53 Trust, London KT1 2JP, UK London EC1M 6BQ, UK of Radiotherapy and Division of Pathology, European Correspondence to: Pan Pantziarka 3 as a case study Breast Services, Division of Surgery and Interventional Institute of Oncology, Milan, Italy Email: [email protected] Science, Whittington Hospital, Magdala Avenue, Correspondence to: Giuseppe Curigliano London N19 5NF, UK Ajay Aggarwal1, 2, Karla Unger-Saldaña3, Grant Email: [email protected] DOI: 10.3332/ecancer.2015.568 ⁴Division of Cancer Prevention and Genetics, European Lewison1 and Richard Sullivan1, 4 Institute of Oncology, Via Ripamonti 435, Milan 20141, 1 Institute of Cancer Policy, Kings College London, DOI: 10.3332/ecancer.2015.518 Italy Guys Campus, Department of Research Oncology, Nitroglycerin (NTG), a drug that has been in clinical ⁵Health Behaviour Research Centre, University College Bermondsey Wing, London, SE1 9RT, UK use for more than a century, has a range of actions London, London WC1E 7HB, UK 2Department of Clinical Oncology, Guys and St Thomas’ The refinement of the classification, the risk of relapse which make it of particular interest in an oncological Correspondence to: Andrea DeCensi NHS Trust, London SE1 9RT, UK and the prediction of response to multidisciplinary setting. It is generally accepted that the main 3 Email: [email protected] Mexican National Cancer Institute (INCan), 14080 treatment for early breast cancer has been the major mechanism of action of NTG is via the production of México, D.F. theme of the 14th St Gallen International Breast Cancer nitric oxide (NO), which improves cardiac oxygenation 4 DOI: 10.3332/ecancer.2015.595 International Prevention Research Institute (iPRI), Lyon Consensus Conference 2015. The meeting, held in via multiple mechanisms including improved blood 69006, France Vienna, assembled 3500–4000 participants from 134 flow (vasodilation), decreased platelet aggregation, Correspondence to: Ajay Aggarwal countries worldwide. It culminated, on the final day, increased erythrocyte O2 release and decreased The global cancer burden continues to rise and the Email: [email protected] with the International Consensus Session, delivered mitochondrial utilization of oxygen. Its vasoactive war on cancer can only be won if improvements by 40–50 of the world’s most experienced
Load more

Recommended publications
  • Download the OECI Magazine 1-2021 File
    Magazine Organisation of European Number 1 - Year 5 Cancer Institutes May 2021 In memory of Index Gordon McVie OECI MAGAZINE n. 1-2021 Message from OECI President 4 Thierry Philip It is with great sadness that the Organisation of European Cancer Institutes remembers the premature loss of Professor J. Gordon McVie, a symbolic figure of the fight Magazine OECI GENERAL Organisation of European Number 1 - Year 5 against cancer and an international authority in cancer research and care. Cancer Institutes May 2021 Europe’s Beating Cancer Plan: time to act 6 Stella Kyriakides Horizon Europe Cancer Mission: where OECI 8 and DIGICORE can support and contribute Simon Oberst and Piers Mahon European Research Infrastructure for cancer research 12 and innovation: new opportunities under Horizon Europe Roberta Zobbi Introducing the DIGital Institute for Cancer 14 Outcomes REsearch “DIGICORE” Digicore Board OECI ACCREDITATION AND DESIGNATION Analysing the hallmarks and data of OECI’s 20 A pioneering oncologist, Professor Mc Vie passed away aged 76, leaving behind a life full 40 accredited centres of achievements with more than 40 years of clinical research, over 350 peer-reviewed Simon Oberst papers and prominent positions in some of the world’s leading cancer organisations. OECI’s Vision and Standards for Comprehensive Cancer Networks 22 After serving for many years as Clinical Director first of the Cancer Research Campaign Simon Oberst and Thierry Philip and then of The Netherland Cancer Institute, Gordon joined the European Institute of Current events in the OECI Accreditation 24 Oncology as adviser to Umberto Veronesi. Alongside Prof. Veronesi, he also set up Editors: and Designation Programme Ecancermedicalscience, an open cancer journal.
    [Show full text]
  • Gordon Mcvie
    Gordon McVie Gordon McVie MD, currently Director of Cancer Intelligence, providing advisory services to the media, patients, pharmaceutical and biotechnology companies as well as founding editor and publisher of ecancermedicalscience, is clinical consultant of the Institute of Molecular Oncology (IFOM) and of the Cancer Studies of the Kings College. Author of over 300 peer-reviewed papers and editorials as well as contributing to numerous books, he currently serves on several committees including the American Association for Cancer Research and the American Society of Clinical Oncology. He also serves on the boards of the National Cancer Institutes of France, Italy and the Netherlands. In the UK, he has been on the boards of cancer institutes in Glasgow, Manchester and London. McVie is also Senior Consultant at the European Institute of Oncology, Visiting Professor at Glasgow University, in Scotland, and Honorary Consultant in Medical Oncology at the Welsh Cancer Institute, Cardiff, Wales. PhDs in science and medicine at Edinburgh University, he was appointed Foundation Senior Lecturer at the Cancer Research Campaign Unit at the University of Glasgow and during the 1980s, as a Consultant in Oncology at the Antoni van Leewenhoek hospital in Amsterdam and also Clinical Research Director at the National Cancer Institute of the Netherlands. From this position he helped to establish the drug development office of the European Organisation for Treatment and Research into Cancer (EORTC) whose was President setting up the present Drug Development Group in Brussels, and with NCI support, the European New Drug Development Network. He contributed to build the Cancer Trials Networks in Scotland, Wales, and England, and was a founding member of the National Cancer Research Institute.
    [Show full text]
  • Contributors, Contents and Foreword
    Contributors Contents Rosita Accardi Maria Leon-Roux Foreword 9 4. Acting for Prevention 261 Clement Adebamowo 4.1 Tobacco Control 262 Bernard Levin 1. Global Cancer Control 11 Ben Anderson Ni Li 4.2 Prevention of Occupational Cancer 270 Philippe Autier Haifa Madi 1.1 Introduction: Needs and Prospects for Cancer Control 12 4.3 Vaccination 274 Robert Baan Patrick Maisonneuve 1.2 Cancer Nomenclature 40 4.4 Cancer Chemoprevention 280 Mariano Barbacid James McKay 1.3 Worldwide Cancer Burden 42 4.5 Screening for Cervical Cancer 288 Paolo Boffetta Kirsten McArdle 1.4 Cancer Control in Low-Resource Environments 56 4.6 Screening for Breast Cancer 296 Mathieu Boniol Gordon McVie 1.5 Principles of Cancer Therapy: Medical Oncology 62 4.7 Screening for Colorectal Cancer 302 Peter Boyle Richard Muwonge 1.6 Basics of Cancer Surgery 68 4.8 Screening for Oral Cancer 304 4.9 Screening for Stomach Cancer 308 Jo Brady Maria-Claudia Nascimento 1.7 Radiotherapy 72 4.10 Screening for Prostate Cancer 310 Anne Brédart Twalib Ngoma 1.8 Principles of Supportive and Palliative Care 76 Paul Brennan Hiroko Ohgaki 4.11 Screening for Ovarian Cancer 314 1.9 Psycho-Oncology 82 Jean-Benoît Burrion Shigeru Omi 4.12 Screening for Lung Cancer 316 1.10 Rehabilitation in Oncology 92 Elodie Caboux Claudio Pelucchi 4.13 Screening for Cutaneous Melanoma 318 Franco Cavalli Luis Pinillos Ashton 1.11 Modern Imaging in Oncology 96 4.14 Genetic Testing 320 Young-eun Cho 1.12 Breast Health Care Delivery in Low- and Middle-Income Countries 100 Samlee Plianbangchang 5.
    [Show full text]
  • P-MEDICINE NEWSLETTERISSUE NO 4 2 No 4 • February 2015 No 4 • February
    P-MEDICINE NEWSLETTERISSUE NO 4 2 no 4 • february 2015 no 4 • february contents Editorial 3 Latest Achievements in the p-medicine project 4 How to Ensure GCP-Compliance for p-medicine Tools 6 Predicting Drug Side Effects: Opportunities and Challenges 8 Browse-Directed Search: A Tool for Generating Hypotheses 9 Partners in Depth: Biovista 11 ECRIN and p-medicine 12 ALGA-BC: An interactive empowerment tool for breast cancer patients 14 MyHealthAvatar: A Demonstration of 4d Digital Avatar Infrastructure 15 VPH-Share Makes Impact at VPH2014 in Trondheim 15 Building Policy Recognition for VPH Research 16 p-medicine newsletter 3 editorial by Norbert Graf, p-medicine coordinator We are fast approaching the end of partner Biovista summarizes the platform will remain. The p-medicine our project now with only six more knowledge gained regarding the partners have agreed to support the months to go. The next half-year will close collaboration of p-medicine development of a legal entity called 2015 no 4 • february be focused on finalising an integrated partners and regulatory bodies, such STaRC: Study, Trial and Research scenario demonstrating all aspects as EMA and FDA. More of Biovista’s Centre that will guarantee that our of the project. All our efforts have interesting work on pages 8-11. fantastic work is continued beyond been put forth to develop tangible the lifetime of p-medicine. scenarios that will convince clinicians At the end of the project we have set to use the p-medicine infrastructure up an infrastructure that will facilitate Of course, these excellent results in their research and their clinical personalized medicine in all aspects, are only possible with a terrific practice.
    [Show full text]
  • UNITED STATES SECURITIES and EXCHANGE COMMISSION Washington, D.C
    UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) [ X ] Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 OR Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the Transition Period from ________ to ________ For the fiscal year ended Commission File number 0-50626 December 31, 2005 CYCLACEL PHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 91-1707622 (State or other jurisdiction (I.R.S. Employer of incorporation or organization) Identification No.) 150 John F. Kennedy Parkway, Suite 100 Short Hills, NJ 07078 (Address of principal executive office) Registrant’s telephone number, including area code (732) 225-8910 Securities registered pursuant to Section 12(b) of the Act: NONE Securities registered pursuant to Section 12(g) of the Act: Common Stock, par value $0.001 per share 6% Convertible Exchangeable Preferred Stock, par value $0.001 per share (Title of class) Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Exchange Act of 1934. Yes No Indicate by check mark if the registrant is not required to file reports required to be filed by Section 13 or Section 15(d) of the Act. Yes No Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
    [Show full text]
  • Cancer Research in Switzerland (Edition 2020)
    2020 Cancer Research in Switzerland Cancer Research in Switzerland A publication of the Swiss Cancer Research foundation, the Swiss Cancer League and the cantonal cancer leagues on their funded research projects 2019 Imprint © Swiss Cancer Research foundation (SCR) and Swiss Cancer League (SCL) All rights reserved by the Research, Innovation & Development department, including the right to reproduce this publication or portions in any form. Publisher and information: Swiss Cancer League Effingerstrasse 40 P. O. Box 8219 CH-3001 Bern Tel. +41 (0)31 389 91 16 [email protected] www.swisscancer.ch /research Article number: 04 1034 02 4121 Publication date: November 2020 English edition: 300 Ex. German edition: 3800 Ex. French edition: 1200 Ex. Responsible: Rolf Marti, PhD Head of Research, Innovation & Development department, Swiss Cancer League Project management and editing: Ori Schipper, PhD Science Writer in Bern, [email protected] English translation: Ellen Russon, East Sandwich, Massachusetts, USA, www.ellenrusson.com Images: Ester Vonplon, Castrisch Design: atelierrichner.ch Print: Ast & Fischer AG, Wabern This edition of the report as well as all previous editions can be downloaded as PDF files at www.swisscancer.ch /researchreport Ester Vonplon (*1980 in Schlieren) lives in Castrisch in the Grisons’ Surselva. Her artistic projects are often inspired by the landscape and nature there. Thus, many of the pictures in this report were taken on hikes during which Ester Vonplon laid plants by the wayside on photographic paper more than a hundred years old. The often blurred shadows (white in the brown negative, dark blue in the inverted positive) bear witness to the wind that moved the fine plants, while the stains in the background are due to ageing processes that bring unexpected disturbing effects to light.
    [Show full text]
  • ANNUAL REPORT 2019 Annual Report 2019 the Future of Cancer Therapy Table of Content
    ANNUAL REPORT 2019 Annual Report 2019 The future of cancer therapy Table of content Message from EORTC Director General 4 State of cancer 6 EORTC network 10 EORTC tumour & cross-discipline groups 13 EORTC infrastructure projects 49 Our partners 53 Engaging patients 54 Fellowships 58 Events & campaigns 59 EORTC general assembly, board & committees 63 Financials 64 The EORTC cancer research fund (ECRF) 66 Publications and clinical trials 2019 77 3 MESSAGE FROM EORTC DIRECTOR GENERAL Driving practice-changing clinical research professionals to become future leaders. The that improves survival and quality of life for Early Career Investigator Leadership Programme cancer patients. This is our mission at the is designed to do just that. In 2019, we engaged EORTC, and one that our community that over 30 young clinical investigators to lead EORTC stretches across Europe and indeed around into an even more audacious future in the fight the world are dedicated to achieve. In 2019, against cancer. we reached major milestones to advance our mission that I am proud to share in this After 50 years leading clinical cancer research, annual report. we have observed weaknesses in European healthcare systems that we strongly believe Our scientific output in 2019 was truly phenom- must be addressed to improve patient treatment enal. EORTC enrolled 2 583 patients in trials and survival. This requires political engagement and screened 3 332 more. We opened 10 trials at European levels, which we officially for enrollment, and continued progressing the embarked on in 2019 with the publication of a 57 ongoing trials from our Brussels headquarters.
    [Show full text]
  • Ca Rcer Research VOLUME 52 9NUMBER 24 9INDEX ISSUE 9CNREA8 ~ PP 6999-7074
    Ca rcer Research VOLUME 52 9NUMBER 24 9INDEX ISSUE 9CNREA8 ~ PP 6999-7074 CONTENTS INDEX TO VOLUME 52 6999 Author Index 7019 Subject Index i Contents of Volume 52 xxi Cover Illustrations for Volume 52 AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC. Officers President, Lee W. Wattenberg President-Elect, Margaret L. Kripke Treasurer, Thomas J. King Executive Director, Margaret Foti Board of Directors Until 1993 June L. Biedler Nancy H. Colburn John Mendelsohn Peter C. Nowell Until 1994 John S. Lazo Lance A. Liotta Sharon B. Murphy Eric J. Stanbridge Until 1995 Curtis C. Harris Victor Ling John D. Minna Kenneth Olden Ex Officio Carlo M. Croee Margaret Foti Thomas J. King Margaret L. Kripke Harold L. Moses Lee W. Wattenberg I. Bernard Weinstein We are pleased to acknowledge the work of Diana F. Certo, who prepared the author index. Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. Contents of Volume 52 January 1, Number 1 1 Relationship of Prediagnostic Serum Levels of Dehydroepiandres- 95 Identification of the Major Protein Components in Breast Secre- 173 ras Transformation of Simian Virus 40-immortalized Rat Hepa- terone and Dehydroepiandrosterone Sulfate to the Risk of Devel- tions from Women with Benign and Malignant Breast Diseases. tocytes: An in Vitro Model of Hepatnearcinogenesis. Xian-Jun oping Premenopausal Breast Cancer. Kathy J. Hclzlsouer, Gary B. Luis M. S~inchez. Francisco Vizoso, Irene Diez-ltzm and Carlos Fang, Michele Flowers, Armand Keating, Ross Cameron, and Gordon, Anthony J. Alberg, Trudy L. Bush, and George W. Lfpez-Otin. Morris Sherman. Comstock.
    [Show full text]
  • Delivering Affordable Cancer Care in High-Income Countries
    The Lancet Oncology Commission Delivering aff ordable cancer care in high-income countries Richard Sullivan, Jeff rey Peppercorn, Karol Sikora, John Zalcberg, Neal J Meropol, Eitan Amir, David Khayat, Peter Boyle, Philippe Autier, Ian F Tannock, Tito Fojo, Jim Siderov, Steve Williamson, Silvia Camporesi, J Gordon McVie, Arnie D Purushotham, Peter Naredi, Alexander Eggermont, Murray F Brennan, Michael L Steinberg, Mark De Ridder, Susan A McCloskey, Dirk Verellen, Terence Roberts, Guy Storme, Rodney J Hicks, Peter J Ell, Bradford R Hirsch, David P Carbone, Kevin A Schulman, Paul Catchpole, David Taylor, Jan Geissler, Nancy G Brinker, David Meltzer, David Kerr, Matti Aapro The burden of cancer is growing, and the disease is becoming a major economic expenditure for all developed Lancet Oncol 2011; 12: 933–80 countries. In 2008, the worldwide cost of cancer due to premature death and disability (not including direct medical See Comment pages 923–32 costs) was estimated to be US$895 billion. This is not simply due to an increase in absolute numbers, but also the Kings Health Partners, King’s rate of increase of expenditure on cancer. What are the drivers and solutions to the so-called cancer-cost curve in College, Integrated Cancer developed countries? How are we going to aff ord to deliver high quality and equitable care? Here, expert opinion Centre, Guy’s Hospital Campus, London, UK from health-care professionals, policy makers, and cancer survivors has been gathered to address the barriers and (Prof R Sullivan MD); Duke solutions to delivering aff ordable cancer care. Although many of the drivers and themes are specifi c to a particular Cancer Institute, Duke fi eld—eg, the huge development costs for cancer medicines—there is strong concordance running through each University Medical Center, contribution.
    [Show full text]
  • A Rationale for Carboplatin Treatment and Abdominal Hyperthermia in Cancers Restricted to the Peritoneal Cavity1
    (CANCER RESEARCH 52, 1252-1258, March 1, 1992] A Rationale for Carboplatin Treatment and Abdominal Hyperthermia in Cancers Restricted to the Peritoneal Cavity1 Gerrit Los,2 Oskar A. G. Smals, Marianne J. H. van Vugt, Martin van der Vlist, Leo den Engelse, J. Gordon McVie, and H. M. Pinedo Divisions of Experimental Therapy [G. L., M. J. H. v. V., M. v. d. V., H. M. P.] and Chemical Carcinogenesis [L. d. E.J, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, and Department of Radiotherapy, University of Amsterdam, Academic Medical Center, Amsterdam [O. A. G. S.J, The Netherlands, and Cancer Research Campaign, London, England [J. G. M.J ABSTRACT cDDP3 is one of the most effective drugs available for i.p. treatment of ovarian carcinoma (9). Trials of single agent cDDP The purpose of this study was to optimize the treatment of cancers restricted to the peritoneal cavity by combining i.p. chemotherapy with or cDDP based combination therapy ¡.p.,in patients with abdominal hyperthermia. In vitro experiments demonstrated that the residual small volume ovarian cancer who had failed to respond uptake of carboplatin into CC531 tumor cells was increased at tempera to i.v. cDDP treatment, have demonstrated beneficial clinical tures higher than 41.5°Catdose levels of 5 and 50% cell kill. Carboplatin- results; 30% complete remissions after single agent cDDP DNA adduct formation and cytotoxicity, however, were already increased treatment (10) and 65% clinically free of disease after cDDP at temperatures of about 40°C,indicating that carboplatin-DNA adduct based combination therapy (11).
    [Show full text]
  • New Clues to Causes of Cachexia
    10 New Clues to Causes of Cachexia ecent research has provided new tumors and cachexia. In one, a poly- “clinicians would probably first want clues to the causes of cachexia. clonal antibody that specifically neu- to find out if the protein is elevated in In one, an animal study now tralizes PTHrP almost completely certain cancers, and determine which online ahead of print in Nature prevented cachexia, while untreated patients would be good candidates for oncology-times.com R(doi:10.1038/nature13528), symptoms animals became mildly cachexic. a clinical trial.” • of cachexia improved or were prevented In the second experiment, the an- The first author of the study is when mice were given an antibody that tibody treatment prevented the loss Serkan Kir, PhD, of the Spiegelman lab blocked the effects of the parathyroid hor- of muscle mass and improved muscle and Robert Black Fellow at the Damon mone-related protein (PTHrP), known to function, while control animals devel- Runyon Cancer Research Foundation. be secreted by tumor cells. oped severe muscle-wasting. Barrett Rollins, MD, PhD, Dana- The researchers, led by Bruce “You would have expected, based Farber’s Chief Scientific Officer, said Spiegelman, PhD, the Stanley J. on our first experiments in cell culture, the report “provides a new roadmap August 10, 2014 Korsmeyer Professor of Cell Biology and that blocking PTHrP in the mice would for developing a rational, mechanisti- • Medicine at Harvard Medical School reduce browning of the fat,” Spiegelman cally based treatment for this incred- and Dana-Farber Cancer Institute, said said in a news release.
    [Show full text]
  • Annual Report
    ANNUAL REPORT 2020 ANNUAL Table of contents REPORT 2020 2020 01 Introduction p5 02 COVID-19 – Impact on cancer clinical trials p10 03 EORTC: In a nutshell p17 04 Changing EORTC Governance p26 05 Spotlight on our members p30 06 EORTC tumour & cross-discipline groups in 2020 p36 07 Infrastructure projects p74 08 EORTC ecosystem p80 09 Patient involvement in clinical research p82 TABLE OF 10 Our policy actions in 2020 p87 11 Fellowships p92 12 Events & campaigns p96 CONTENTS 13 2020 Financial overview p104 14 The EORTC Cancer Research Fund (ECRF) p106 15 Publications 2020 p120 16 Clinical Trials 2020 p132 ANNUAL REPORT 2020 INTRODUCTION 5 Introduction FOREWORD BY DR DENIS LACOMBE, EORTC DIRECTOR GENERAL Covid-19 made 2020 an especially to these challenges. Through collaboration, we can challenging year for the EORTC, but ensure that clinically relevant questions can work it also showcased our organisation’s to optimise treatments and define therapeutic strategies free of commercial interest. remarkable resilience in the face of adversity. Whilst we celebrated the launch of the EU’s Beating Cancer Plan, we made sure to highlight In relatively short time, we managed to transform the absence of treatment optimisation that is our entire organisation to a remote and vital to innovation in oncology. We are continuing virtual workforce still able to carry out research our efforts with policymakers to rectify this in the operations. Although we had to suspend patient Plan. The role of EORTC is being acknowledged recruitment into trials early in the pandemic, as it now appears in the Porto Resolution by the our network innovated and found Covid-safe EU Portugal presidency, as a solution for clinical ways to restart that improve patient survival research infrastructure in Europe.
    [Show full text]