Journal Video News Education ecancer.org is a free online platform for oncology Statistics since launch in 2007 professionals incorporating an open-access journal, news, video and education. 3.5 million visitors 183 international 11 million video from 196 countries conferences filmed views Nurses Other Medical Radiation Oncologists Professionals 1 2 3 4 5 - 6 Surgeons Who we are Statistics since Editorial Board Journal News Abstracts Industry launch and Scope 7 - 8 9 10 12 13 Medical Oncologists ecancer.tv Education Latin American ecancerpatient Supporters Research Scientists Edition 14,000 members Journal Video News Education Twitter Facebook LinkedIn iTunes U 8,000 1,600 6,200 23,000 1 *figures correct as of January 2016 2 Editorial Board “The journal has gone from strength to strength, it has become a platform which I consider to be Professor Claudio Basilico ecancermedicalscience is the open access cancer Pay what you can afford publishing model a first choice for submitting my NYU School of Medicine, New York, USA journal of the European Institute of Oncology, publications. The advantages of Milan (IEO) and the Organisation of European It’s been two years since we launched our ecancer include the very efficient, Professor Pier Paolo Di Fiore Cancer Institutes (OECI). pioneering “Pay what you can afford” publishing personal service, the wide variety of European Institute of Oncology, Milan, Italy model and so far it’s been a great success. We articles which are published and the Journal facts and figures ask authors who have received funding which is Professor Alexander Eggermont specifically provided for open access publication fact that they are shared so widely Institut Gustave Roussy, Paris, France • No article processing charge for those without (mandated by many governments and funders) to with a truly international focus.” funding pay towards an Article Processing Charge (APC) Dr Rachel Iredale, Director of Cancer Support, Professor Aaron Goldhirsch • No subscription charges upon acceptance after peer review. In this way we European Institute of Oncology, Milan, Italy Tenovus Cancer Care, and Reader in Public • Publication in two months ensure that authors with no funding are partially Engagement, University of South Wales • Rejection rate 50% supported by those who can afford to pay an APC. Professor Gordon McVie, Managing • Submissions accepted in English, Spanish and Editor Portuguese This publishing model is now being adopted European Institute of Oncology, Milan, Italy • Articles viewed 50,000 times a month by other publishers, evidence that where Special issues Professor Roberto Orecchia ecancermedicalscience innovates, others follow. University of Milan and European Institute of Oncology, It allies perfectly with our mission of breaking A minimum of four special issues a year are Milan, Italy Indexed in PubMed, PubMed Central, Scopus, down financial, geographic and linguistic barriers published in ecancermedicalscience on hot topics Embase, EBSCO and Google Scholar and to cancer communication. As a not-for-profit in a wide range of subject areas. We publish in Professor Pier Giuseppe Pelicci included in the core collection of Web of Science organisation, we make sure that all the funding we multiple languages wherever possible – recent European Institute of Oncology, Milan, Italy receive is re-invested in the community we serve. special issues include Cervical cancer prevention in Latin America (available in Spanish and English) Professor Richard Sullivan and Biomarkers, screening and prevention in Council for Emerging National Security Affairs and Kings The Founding Editors are highly respected and cancer. Upcoming topics to be reported on include College, London, UK authoritative leaders each representing a Novel technologies in breast cancer surgery and different field of cancer research. Pharmacoeconomics. Professor Umberto Veronesi, Founding Editor If you have any suggestions for potential special European Institute of Oncology, Milan, Italy Professor Gordon McVie issues, or are interested in becoming a guest editor is the Managing Editor of or author, please contact our scientific editor, Dr Professor Giuseppe Viale ecancermedicalscience. He is Linda Cairns at [email protected] University of Milan and European Institute of Oncology, widely regarded as a leading Milan, Italy international authority in the research and treatment of Views of ecancermedicalscience articles on PubMed Central Professor Luis Pinillos-Ashton cancer, having been CEO of Cancer Research National Cancer Institute of Peru (INEN), Lima, Peru UK. He is Visiting Professor in Cancer Studies at Kings College London and the University of Maria S Pombo-de-Oliveira Extra author services Research Center of Instituto Nacional de Câncer (INCA), Milan where he also advises the FIRC Institute Rio di Janeiro, Brazil of Molecular Oncology. We provide a free language editing service to all our authors, as well as free translation of Spanish and Professor Rajiv Sarin Portuguese articles. All ecancermedicalscience Advanced Centre for Treatment Research and Education Professor Umberto Veronesi articles have Article Level Metrics, so authors are over 2000 authors have in Cancer (ACTREC), Tata Memorial Centre, Mumbai, is the Founding Editor of able to monitor the impact of their articles and India published for free ecancermedicalscience. access statistics on how many people have read He is the Founder and their work in a variety of international repositories, Professor Cornelis J H van de Velde Emeritus Director of the Leiden University Medical Center, The Netherlands social media and online reference managers. European Institute of Oncology, Milan and is the pioneer of breast- conserving surgery. 533 articles from 57 countries 3 4 Abstracts Conference Report Clinical Study Special Issue Highlights from the 14th St Gallen Repurposing Drugs in Oncology (ReDO)— Barriers to preventive therapy for breast The following is a small selection of International Breast Cancer Conference nitroglycerin as an anti-cancer agent and other major cancers and strategies to ecancermedicalscience abstracts, all of these articles appear in PubMed Central and are freely available to 2015 in Vienna: Dealing with classification, improve uptake Vidula Sukhatme1, Gauthier Bouche2, Lydie Meheus2, view online. prognostication, and prediction refinement 1, 3 2, 4 Vikas P Sukhatme , Pan Pantziarka Andrea DeCensi1, 2, Mangesh A Thorat2, 3, Bernardo to personalize the treatment of patients with 1 GlobalCures, Inc, Newton MA 02459, USA Bonanni4, Samuel G Smith2, 5 and Jack Cuzick2 2 early breast cancer Anticancer Fund, Brussels, 1853 Strombeek-Bever, 1Division of Medical Oncology, E.O. Ospedali Galliera, Belgium Mura delle Cappuccine 14, Genoa 16128, Italy 3 Review Angela Esposito, Carmen Criscitiello and Giuseppe Beth Israel Deaconess Medical Center and Harvard 2Centre for Cancer Prevention, Wolfson Institute of The challenge of cancer in middle-income Curigliano Medical School, Boston, MA 02215, USA Preventive Medicine, Queen Mary University of London, 4 countries with an ageing population: Mexico Division of Experimental Cancer Medicine, Division The George Pantziarka TP53 Trust, London KT1 2JP, UK London EC1M 6BQ, UK of Radiotherapy and Division of Pathology, European Correspondence to: Pan Pantziarka 3 as a case study Breast Services, Division of Surgery and Interventional Institute of Oncology, Milan, Italy Email: [email protected] Science, Whittington Hospital, Magdala Avenue, Correspondence to: Giuseppe Curigliano London N19 5NF, UK Ajay Aggarwal1, 2, Karla Unger-Saldaña3, Grant Email: [email protected] DOI: 10.3332/ecancer.2015.568 ⁴Division of Cancer Prevention and Genetics, European Lewison1 and Richard Sullivan1, 4 Institute of Oncology, Via Ripamonti 435, Milan 20141, 1 Institute of Cancer Policy, Kings College London, DOI: 10.3332/ecancer.2015.518 Italy Guys Campus, Department of Research Oncology, Nitroglycerin (NTG), a drug that has been in clinical ⁵Health Behaviour Research Centre, University College Bermondsey Wing, London, SE1 9RT, UK use for more than a century, has a range of actions London, London WC1E 7HB, UK 2Department of Clinical Oncology, Guys and St Thomas’ The refinement of the classification, the risk of relapse which make it of particular interest in an oncological Correspondence to: Andrea DeCensi NHS Trust, London SE1 9RT, UK and the prediction of response to multidisciplinary setting. It is generally accepted that the main 3 Email: [email protected] Mexican National Cancer Institute (INCan), 14080 treatment for early breast cancer has been the major mechanism of action of NTG is via the production of México, D.F. theme of the 14th St Gallen International Breast Cancer nitric oxide (NO), which improves cardiac oxygenation 4 DOI: 10.3332/ecancer.2015.595 International Prevention Research Institute (iPRI), Lyon Consensus Conference 2015. The meeting, held in via multiple mechanisms including improved blood 69006, France Vienna, assembled 3500–4000 participants from 134 flow (vasodilation), decreased platelet aggregation, Correspondence to: Ajay Aggarwal countries worldwide. It culminated, on the final day, increased erythrocyte O2 release and decreased The global cancer burden continues to rise and the Email: [email protected] with the International Consensus Session, delivered mitochondrial utilization of oxygen. Its vasoactive war on cancer can only be won if improvements by 40–50 of the world’s most experienced