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Rabbit Anti-QSOX2/FITC Conjugated antibody

SL19698R-FITC

Product Name: Anti-QSOX2/FITC Chinese Name: FITC标记的巯基氧化酶2抗体 DKFZp762A2013; Neuroblastoma-derived sulfhydryl oxidase; QSCN6L1; QSOX2; Alias: QSOX2_HUMAN; Quiescin Q6 like 1; Quiescin Q6 sulfhydryl oxidase 2; Quiescin Q6-like protein 1; SOXN; Sulfhydryl oxidase 2. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 76kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human QSOX2 Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01Mwww.sunlongbiotech.com TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied Product Detail: by OMIM, Jun 2009]

Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.

Subcellular Location: Membrane. Secreted. Cell membrane. Nucleus membrane. Seems to be predominantly targeted to the nuclear and outer plasma membrane.

Tissue Specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.

Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Contains 1 ERV/ALR sulfhydryl oxidase domain. Contains 1 thioredoxin domain.

Database links:

Entrez Gene: 788063 Cow

Entrez Gene: 607571 Dog

Entrez Gene: 101144374 Gorilla

Entrez Gene: 169714 Human

Entrez Gene: 227638 Mouse

Entrez Gene: 100020838 Opossum

Entrez Gene: 681023 Rat Omim:www.sunlongbiotech.com 612860 Human SwissProt: Q6ZRP7 Human

SwissProt: Q3TMX7 Mouse

Unigene: 657864 Human

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.