4529 Review Article Pneumothorax in otherwise healthy non-intubated patients suffering from COVID-19 pneumonia: a systematic review Apostolos C. Agrafiotis1^, Peter Rummens2, Ines Lardinois1 1Department of Thoracic Surgery, Saint-Pierre University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium; 2Department of Respiratory Medicine, Saint-Pierre University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium Contributions: (I) Conception and design: AC Agrafiotis; (II) Administrative support: P Rummens, I Lardinois; (III) Provision of study materials or patients: AC Agrafiotis, P Rummens; (IV) Collection and assembly of data: AC Agrafiotis, P Rummens; (V) Data analysis and interpretation: AC Agrafiotis, P Rummens; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Dr. Apostolos C. Agrafiotis. Department of Thoracic Surgery, Saint-Pierre University Hospital, Rue Haute 322, 1000 Brussels, Belgium. Email:
[email protected]. Background: Cases of spontaneous pneumothorax have been described in patients suffering from coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study is to systematically review all the cases of spontaneous pneumothorax that occurred in healthy patients with no underlying lung disease and who did not receive invasive mechanical ventilation. Methods: A PubMed research was conducted. The following data were collected: age, sex, side of the pneumothorax, smoking habit, time form onset of symptoms to the diagnosis of pneumothorax, the development of new bullous lesions on computed tomography and the type of treatment. In order to analyze the most homogeneous population possible, intubated patients were deliberately excluded. In total, 44 cases of spontaneous pneumothorax in otherwise healthy patients were taken into account.