antioxidants Review Kidney Protection with the Radical Scavenger α1-Microglobulin (A1M) during Peptide Receptor Radionuclide and Radioligand Therapy Amanda Kristiansson 1,* , Anders Örbom 1, Oskar Vilhelmsson Timmermand 1, Jonas Ahlstedt 2, Sven-Erik Strand 1,3 and Bo Åkerström 4 1 Department of Clinical Sciences Lund, Oncology, Lund University, 221 00 Lund, Sweden;
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[email protected] (S.-E.S.) 2 Department of Clinical Sciences Lund, CIPA, Lund University, 221 84 Lund, Sweden;
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[email protected] Abstract: α1-Microglobulin (A1M) is an antioxidant found in all vertebrates, including humans. It has enzymatic reductase activity and can scavenge radicals and bind free heme groups. Infused recombinant A1M accumulates in the kidneys and has therefore been successful in protecting kidney injuries in different animal models. In this review, we focus on A1M as a radioprotector of the Citation: Kristiansson, A.; Örbom, kidneys during peptide receptor radionuclide/radioligand therapy (PRRT/RLT). Patients with, e.g., A.; Vilhelmsson Timmermand, O.; neuroendocrine tumors or castration resistant prostate cancer can be treated by administration of Ahlstedt, J.; Strand, S.-E.; Åkerström, radiolabeled small molecules which target and therefore enable the irradiation and killing of cancer B. Kidney Protection with the Radical cells through specific receptor interaction.