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Namenverzeichnis. Author Index Kursiv gedruckte Seitenzahlen beziehen sich auf Literaturverzeichnisse Page numbers printed in italies refer to References Abdel-Kader, M. M. 148 Aota, K. 373 Abdurahman, N. 518 Applegate, H. E. 54 Abe, J. 53 Arakawa, H. 206 Abel, H. 462 Archer, R. A. 53 Abeles, R. H. 624,625,626,627 Ardenne,M.von 394,406,466 Abraham, E. P. 53 Arigoni, D. 458,469,624,628 Abrahamsson, S. 114 Arima, K. 117 Achilladelis, B. 109, 114 Aritomi, M. 187,189,206 Achini, R. 114 Armuth, V. 458 Acker, T. E. 274 Arndt, F. 274 Aczel, St. 216 Arndt, H. G. 210 Adams, M. H. 529,578 Arnold, N. H. 280 Adams, P. M. 114 Aron, E. 274 Adams, R. 219,280 Arroyo, E. R. 408, 448, 458, 466 Adamska, M. 184, 189,206 Arth, G. E. 60 Adinarayana 188 Asao, T. 148 Ager, I. 53 Asen, S. 187, 190 Aichner, F. X. 191,209 Ashbrook, C. W. 57 Alberty, R. A. 623 Asselin, A. 372 Alburn, H. E. 56 Atherton, D. R. 576 Alderweireldt, F. C. 458 Aurnhammer, G. 206,211, 214, 215 Aldrich, P. 518 Algar, J. 199,206 Babel, R. B. 56 Allan, J. 201, 206 Babior, B. M. 623,625 Allen, B. 579 Bader, F. E. 518 Allen, S. H. G. 627 Baeyer, A. 275 Allport, D. C. 274,575 Bagnara, J. D. 575 Alston, R. E. 177, 186,206,212,215 Bailar, J. C. 149 Amos 148 Baird, D. B. 570,575 Andersen, N. H. 283,287,293,304,328,346, Baird, R. 299,372 371, 372, 374 Baird, W. M. 455,458 Anderson, E. L. 518 Baker, P. M. 271,275 Ando, K. 117 Baldwin, J. E. 57 Ando, T. 212 Balenovic, K. 275 Andrews, S. I. 59 Balmain, A. 458 Ang, S. K. 518 Baltimore, B. G. 626 Aoki, Y. 211 Bamberg, P. 53 630 Namenverzeichni,. Author Index Bamburg,1. R. 83, 112,114,148 Bhatia, V. K. 188, 189,206 Ban, Y. 473,518 Bhutani, S. P. 188,206 Barb, M. S. 187 Bickel, H. 55.60.518 Barbesgard, P. 277 Bied-Charreton, C. 629 Barczai-Beke, M. 473,518 Bielka, H. 461 Barczai-Martos, M. 191,206 Bieri, 1. G. 629 Barden, H. 575 Binns, F. 546, 547, 567, 570, 575 BargelJini, G. 195 Biol, M. C. 206 Barger, B. 188,206 Biollatz, M. 148 Barger, G. 148 Birch, A. J. 218,222,223,224,225,226,238, Barker, H. A. 622,623,626,627,628 244,246,250,252,275.372 Barrett, H. C. 314,372 Birkhofer, L. 175,206 Barton, D. H. R. 28,53 Birkinshaw,1. H. 148 Barton, J. E. D. 518 Birnbaum, G. I. 464 Bartosinski, B. 624 Birnbaum, J. 622 Bartsch, H. 458,459,462,463 Black, D. R. 151 Barz, W. 210 Blackley, R. L. 625.626,629 Bassett, C. 148 Bloch, B. 528,530,559,575 Bassett, R. N. 61 Bloch, K. 222,281 Batchelor, F. R. 53 Blois, M. S. 559, 563, 564, 575, 576. 582 Bates, R. B. 374 Blois, M. S. Jr. 575. 576 Battacharyya, S. C. 284,309,313,314,374,376 Blumental, G. 580 Battersby, A. R. 469 Bocian, G. E. 56 Batyuk, V. S. 206 Bodenstein, C. K. 275 Baxter, I. 570, 575 Boehm, R. 380,411,455,459 Bayse, G. S. 532,575 Bogmlr, R. 166, 193, 194, 207, 215. 216 Bear, C. A. 148 Böhme, E. H. W. 54 Beattie, T. R. 54 Böhner, B. 114,115.117 Beck, J. 518 Bollenback, G. N. 191,207 Beck, K. 210 Boltze, K.-H. 275 Beck, W. S. 626 Bonner, T. G. 576 Becker, F. 206 Boole, L. E. 380, 460 Becker, S. W. Jr. 529,577 Borchert, P. 416,418,420 Beckham, T. M. 623,628 Borer, C. 372 Bedford, C. T. 275 Borg, D. C. 565, 577. 582 Beer, R. J. S. 526, 542, 575 Borsche, W. 275 .Beerthuis, R. K. 149 Bose, A. K. 2, 58 Belanger, A. 374 Bouchez, M. P. 169,212 Bell, M. R. 53. 54 Bouchilloux, S. 527, 554,576,579 Benjamin, D. G. 207 Bouillant, M. L. 207.212 Bennet, G. B. 518 Bourquelot, E. 524 Bentley, R. 255,275 Boutard, B. 207 Benzing, E. 279 Boutwell, R. K. 455, 458. 459. 465 Berenblum, I. 379, 380, 384,457,458,459 Bowden, J. P. 64,115 Berger, F. 459 Bowness, J. M. 576 Bergmann, M. 208 Brachmann, I. 462 Bernhard, K. 459 Brackman, W. 576 Bernhauer, K. 624 Bradbeer, C. 625 Bertrand, G. 524 Brady, St. F. 283,374 Bertrand, J. A. 373 Brain, E. G. 54 Bethell, J. R. 244, 275 Bram, G. 229,232,252,275 Beton, J. L. 154,214 Brandl, F. 463 Beyersdorff. P. 2!O Brandt, K. G. 60 Namenverzeichnis. Author Index 631 Braunschweiger, H. 165,209 Carlson, 1. A. 53 Brechbühler, S. 148 Carnaghan, R. B. A. 151 Bredereck, H. 192, 193,209 Carnduff, J. 259,276 Brenneisen, P. E. 274 Carney, R. L. 278 Bresch, H. 458,459,462,463 Carter, L. 190 Brian, P. W. 64,115 Carty, D. J. 625 Bridger, R. F. 151 Casnati, G. 236,276 Bright, H. J. 576 Cathou, R. E. 629 Broadhurst, T. 526,542,575 Cava, M. P. 519 Brown, D. G. 625 Cederbaum, S. 627 Brown, H. W. 576 Chabannes, B. 207 Brown, K. S. 275 Chadenson, M. 207 Brown, L. D. 54 Chan, J. K. 279 Brown, R. T. 518 Chandler, B. V. 175,207 Brownson, C. 625, 626 Chaney, M. O. 58 Brück, D. 465 Chang, C. F. 214 Bruenger, F. W. 576 Chang, S. B. 148 Bruice, T. C. 276 Chapman, R. F. 547,570,575,576 Brunwin, D. M. 54 Chari, V. M. 215 Buchanan, J. M. 629 Chaumont, 1. P. 209 Buchanan, M. 148 Chauvelier, 1. 276 Buchheim, R. 427,459 Chauvette, R. R. 54,57 Büchi, G. 128, 134, 135, 136, 144, 148, 314, Chavin, W. 554, 576 372,491,502,510,513,519 Chen, Y. M. 554,576 Bucourt, R. 410,459 Cheney, L. C. 55,56,59 Budweg, W. 21J, 215 Cheng, F. C. 243,268,276 Bullock, E. 148 Cheng, J. C. 55 Bullot, J. 279 Cherbuliez, E. 380, 460 Bu'Lock, J. D. 274. 276. 526, 527, 540, Chernobrovaya, N. V. 206 541, 543, 545, 553, 566~ 575, 576, Cheung, K. K. 148 578 Chibber, S. S. 206 Bundgaard, H. 54 Chiurdog1u, G. 372 Bundy, G. 372 Chivers, B. R. 465 Burgstahler, A. W. 518 Chopin, J. 177, 179, 184, 189, 191, 197,204, Burkhardt, H. J. 148 205,206,207,212,214 Burnett, J. 580 Chow, A. W. 54 Busch, H. 462 Chow, J. H. S. 214 Bushnell, A. J. 214 Chow, W. Z. 372, 374 Butcher, B. T. 54 Christensen, B. G. 54,56,57 Butenandt, A. 377 Chumbalov, T. K. 187 Butler, T. C. 54 Ciegler, A. 149 Butler, W. H. 148 Cignarella, G. 54 Bycroft, B. W. 271, 275, 276 C1aes, P. 61 By1sma, F. 518,519 Claesen, M. 55 C1ark, D. E. 56 Caine, D. 340,372 Clark, J. M. Jr. 627 Caldwell, S. M. 61 C1arke, E. 460 Cama, L. D. 54 Clarke, H. T. 54 Cameron, D. W. 275 C1ayton, J. P. 54 CampelI, A. D. 151 C1emans, S. D. 54 Canter, F. W. 207 Clements, F. E. 115 Capon, B. 459 Clemo, G. R. 543,576 Carle, A. 181. 209 Coates, R. M. 372 632 Namenverzeichnis. Author Index Cockle, S. A. 623 D'Arcy, A. D. 207 Codner, R. C. 280 Dave, K. D. 519 Coffen, D. L. 519 Davies, J. E. 149 Cole, R. J. 148 Davies, S. P. 623 Coleman, G. H. 193,212 Davis, W. W. 61 Collie, J. N. 218,219,220,221,222,230,244, Dawson, C. R. 533, 535, 536, 544,577 246,276 Dawson, J. B. 340,372 Colvin, E. W. 99,115 Dean, F. M. 244,277 Combs, C. S. Jr. 278 De Boer, Th. J. 416,465 Corner, F. 53 Decot, J. 372 Corner, F. W. 276, 280 De J~ng, K. 149 Commoner, B. 563,576 Dekker, E. E. 627 Conia, J. M. 304,372 Delaroff, V. 459 Connellan, J. 625 Delaveau, P. 213 Co oper, C. M. 53 Dellamonica, G. 197,207 Co oper, R. D. G. 53, 54, 55, 56, 58 Della Porta, G. 577, 578, 581 Corey, E. J. 372 De Marco, P. V. 53, 55, 58 Corey, H. S. 280 De Mayo, P. 373 Cornelius, H. 276 Demoie, E. 301,372 Cornforth,1. W. 115 Dennen, D. W. 55 Cornforth, R. H. 115 Deshapande, S. S. 277 Coronelli, C. 55 Deslongchamps, P. 331,372,374 Costa, G. 623 Detroy, R. W. 149 Costilow, R. N. 627 Deutsch, E. 622 Costin, C. R. 371 Dewdney, J. M. 60 Craig, L. C. 460, 465 De Weck, A. L. 60, 61 Crandall, T. G. 300,372 Dickens, F. 149 Crast, L. B. 56,59 Dickermann, H. W. 629 Crescenzi, S. 581 Dieckmann, H. 115 Cressman, W. A. 55 Diedrichs, H. H. 207 Cretney, W. J. 518 Dilworth, M. J. 629 Cromartie, R. 1. T. 526, 542, 577 Dingankar, Y. V. 277 Crombie, L. 243,255,269,276,277,404,435, DirscherI, R. 207,210,215 438,440,460,464 Dix, P. A. 282 Crowden, R. K. 187 Djerassi, C. 280,376,460 Crowfoot Hodgkin, D. 622 Dobson, R. L. 581 Crürös, Z. 216 Dobson, T. A. 276 Curd, F. H. 207 Dockner, T. 55 Curtis, P. J. 115 Doi, S. 116 Curtis, R. F. 148 Dolfini, J. E. 54,519 Curtis, R.
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    EVALUATION OF ANTICANCER ACTIVITIES OF PHENOLIC COMPOUNDS IN BLUEBERRIES AND MUSCADINE GRAPES by WEIGUANG YI (Under the Direction of CASIMIR C. AKOH) ABSTRACT Research has shown that diets rich in phenolic compounds may be associated with lower risk of several chronic diseases including cancer. This study systematically evaluated the bioactivities of phenolic compounds in blueberries and muscadine grapes, and assessed their potential cell growth inhibition and apoptosis induction effects using two colon cancer cell lines (HT-29 and Caco-2), and one liver cancer cell line (HepG2). In addition, the absorption of blueberry anthocyanin extracts was evaluated using Caco-2 human intestinal cell monolayers. Polyphenols in three blueberry cultivars (Briteblue, Tifblue and Powderblue), and four cultivars of muscadine (Carlos, Ison, Noble, and Supreme) were extracted and freeze dried. The extracts were further separated into phenolic acids, tannins, flavonols, and anthocyanins using a HLB cartridge and LH20 column. In both blueberries and muscadine grapes, some individual phenolic acids and flavonoids were identified by HPLC with more than 90% purity in anthocyanin fractions. The dried extracts and fractions were added to the cell culture medium to test for cell growth inhibition and induction of apoptosis. Polyphenols from both blueberries and muscadine grapes had significant inhibitory effects on cancer cell growth. The phenolic acid fraction showed relatively lower bioactivities with 50% inhibition at 0.5-3 µg/mL. The intermediate bioactivities were observed in the flavonol and tannin fractions. The greatest inhibitory effect among all four fractions was from the anthocyanin fractions in the three cell lines. Cell growth was significantly inhibited more than 50% by the anthocyanin fractions at concentrations of 15-300 µg/mL.
  • Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens

    Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens

    International Journal of Molecular Sciences Review Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens Anna Helena Mazurek 1 , Łukasz Szeleszczuk 1,* , Thomas Simonson 2 and Dariusz Maciej Pisklak 1 1 Chair and Department of Physical Pharmacy and Bioanalysis, Department of Physical Chemistry, Medical Faculty of Pharmacy, University of Warsaw, Banacha 1 str., 02-093 Warsaw Poland; [email protected] (A.H.M.); [email protected] (D.M.P.) 2 Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, 91-120 Palaiseau, France; [email protected] * Correspondence: [email protected]; Tel.: +48-501-255-121 Received: 21 July 2020; Accepted: 1 September 2020; Published: 3 September 2020 Abstract: In this review, applications of various molecular modelling methods in the study of estrogens and xenoestrogens are summarized. Selected biomolecules that are the most commonly chosen as molecular modelling objects in this field are presented. In most of the reviewed works, ligand docking using solely force field methods was performed, employing various molecular targets involved in metabolism and action of estrogens. Other molecular modelling methods such as molecular dynamics and combined quantum mechanics with molecular mechanics have also been successfully used to predict the properties of estrogens and xenoestrogens. Among published works, a great number also focused on the application of different types of quantitative structure–activity relationship (QSAR) analyses to examine estrogen’s structures and activities. Although the interactions between estrogens and xenoestrogens with various proteins are the most commonly studied, other aspects such as penetration of estrogens through lipid bilayers or their ability to adsorb on different materials are also explored using theoretical calculations.
  • Assembly of a Novel Biosynthetic Pathway for Production of the Plant Flavonoid Fisetin in Escherichia Coli

    Assembly of a Novel Biosynthetic Pathway for Production of the Plant Flavonoid Fisetin in Escherichia Coli

    Downloaded from orbit.dtu.dk on: Oct 06, 2021 Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli Stahlhut, Steen Gustav; Siedler, Solvej; Malla, Sailesh; Harrison, Scott James; Maury, Jerome; Neves, Ana Rute; Förster, Jochen Published in: Metabolic Engineering Link to article, DOI: 10.1016/j.ymben.2015.07.002 Publication date: 2015 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Stahlhut, S. G., Siedler, S., Malla, S., Harrison, S. J., Maury, J., Neves, A. R., & Förster, J. (2015). Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli. Metabolic Engineering, 31, 84-93. https://doi.org/10.1016/j.ymben.2015.07.002 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Metabolic Engineering 31 (2015) 84–93 Contents lists available at ScienceDirect Metabolic Engineering journal homepage: www.elsevier.com/locate/ymben Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli Steen G.