Children with Leukaemia Annual Review 2007
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CHILDREN with LEUKAEMIA, 51 Great Ormond Street, London WC1N 3JQ Registered Charity No. 298405 Tel: 020 7404 0808 Fax: 020 7404 3666 email: [email protected] This report is available on our website at www.leukaemia.org. 20 Dr Gordon Strathdee, University of Newcastle upon Tyne. Functional relevance of CHILDREN with LEUKAEMIA loss of HOX gene expression in childhood leukaemia. around Britain 21 Dr Richard Feltbower, University of Leeds. Does population mixing measure infectious exposure at the community level? KEY 22 Minimal residual disease study, Sheffield Research facilities Children’s Hospital. Research projects 23 Childhood Cancer and Leukaemia Group, Welfare projects Leicester. Clinical trial infrastructure support. 24 Leukaemia CARE, Paediatric Patient 1 Dr Rob Mairs, University of Conference, Birmingham Children’s Hospital. Glasgow. Determination of the mutagenicity in murine 16 25 Paul O’Gorman Patient Hotel, Great haemopoietic progenitors of Ormond Street Hospital for Children, London. extremely low frequency 26 Paul O’Gorman Leukaemia Research electromagnetic fields and Centre, Institute of Child Health, London. ionising radiation using 2 3 microsatellite analysis. 1 27 Institute of Cancer Sciences, Paul O’Gorman Building, University College London. 2 Paul O’Gorman Leukaemia Research Centre, University of Glasgow 28 Expansion of Haematology and Oncology (due to open 2008). Services, Great Ormond Street Hospital, 17 London. 3 Minimal residual disease study, Royal 18 20 Hospital for Sick Children, Glasgow. 19 29 Paul O’Gorman Laboratory of Cellular Therapeutics, Royal Free Hospital, London. 4 Young Oncology Unit, Christie Hospital, Manchester. 30 Dr Owen Williams. Paul O’Gorman Leukaemia Research Centre, Institute of Child Health, London. The role of MLL in the 5 Paul O’Gorman Blood Laboratory, Wolfson molecular pathogenesis of infant and childhood Molecular Imaging Centre, University of leukaemia. Manchester. 21 31 Minimal residual disease study, Barts and 6 Paul O’Gorman Molecular Diagnostic 4 Royal London Hospital, London. 6 7 22 Laboratory, The Paterson Institute, Christie 5 8 Hospital, Manchester. 32 Paul’s House, University College London Hospital (due 7 DNA sequencer, Cancer Immunogenetics to open in 2008). Laboratory, University of Manchester. 23 24 33 Professor Mel Greaves, 8 Dr Malcolm Taylor, University of Institute of Cancer Research, Manchester. The role of HLA genes in 10 9 London. Collateral DNA protection from childhood leukaemia. damage as an indicator of prior 9 Dr Ketal Patel, MRC Laboratory of aetiological exposures in infant Molecular Biology, Cambridge. leukaemia. 11 36 25 34 26 30 Identification and characterisation of novel 37 32 13 27 31 34 genes that function in the Fanconi anaemia 12 33 Professor Chris Boshoff, 14 28 29 tumour suppressor pathway. 15 35 University College London Cancer Institute. Childhood cancer 10 Alasdair Philips, Cambridge. An exploration programme funding: 1) Shoc2 in of the possible causes of childhood leukaemia Ras-driven leukomogenesis; 2) Micro- and other cancers. metastatic sarcoma models; and 3) High content cell screening for signaling pathways. 11 Paul O’Gorman Laboratory, Coghill Research Laboratories, Gwent. 35 The Variety Club of Great Britain, London. 16 Paediatric Nursing Award Scheme, training 12 Paul O’Gorman Building, Bristol Professor Eric Wright, University of Dundee Medical School. Investigations of microenviron- grants to 28 nurses across the UK. Royal Hospital for Children. mentally-mediated damage as a promotional factor in childhood leukaemia. 36 Dr Mike Murphy, Childhood Cancer 13 Professor Denis Henshaw, Human Radiation Research Group, University of Oxford. Effects Group, University of Bristol. Programme 17 Northern Institute of Cancer Research, Paul Programme funding - studies into risk factors funding – studies into environmental risk O’Gorman Building, University of Newcastle for childhood leukaemia. factors for childhood leukaemia. upon Tyne. Annual Report & Accounts 2007 37 Dr Mark Lowdell, Paul O’Gorman 14 Minimal residual disease study, University of 18 Dr Tevfik Dorak, University of Newcastle Bristol. upon Tyne. Genes influencing body iron Laboratory of Cellular Therapeutics, Royal Free content and childhood leukaemia risk. Hospital. Project funding. TaNK project. 15 Dr Craig Donaldson, University of the West 19 of England. A study of human NKT cells in stem Professor Andrew Hall, University of cell transplant recipients. Newcastle upon Tyne. Drug resistance in children with acute lymphoblastic leukaemia. CHILDREN with LEUKAEMIA CHILDREN with LEUKAEMIA Registered Charity No. 298405. Inaugurated in 1988 by Diana, Princess of Wales in memory of Jean and Paul O’Gorman Registered Charity No. 298405. Inaugurated in 1988 by Diana, Princess of Wales in memory of Jean and Paul O’Gorman Introduction Foreword by the chairman 2007 was our 20th year. The past two decades have seen CHILDREN with LEUKAEMIA Annual total income vast growth and achievement for the charity, making huge progress in the £14 million fight against leukaemia. £12 million Since the beginning of the new £10 million millennium, much has changed. In 1999 we were still fighting the UK’s £8 million biggest child killer disease - today £6 million treatment has so advanced that more children than ever survive. £4 million But one thing hasn’t changed. We £2 million are still fighting the UK’s most £0 million common childhood cancer and 1999 2000 2001 2002 2003 2004 2005 2006 2007 Our commitment comes from the heart despite our best efforts we still do Year not understand what causes children to develop the disease. That’s why an increasing proportion of our expenditure will be focused The charity began in 1988 in Paul, pictured above, with his Despite the loss of their beloved on advancing our understanding of memory of Paul O’Gorman, who sister Jean, succumbed to the children, Eddie and Marion, the causes and the potential for the was 14 when he was diagnosed disease in February 1987, just along with family and friends, prevention of childhood leukaemia. Leukaemia deaths in children aged 0 to 14 years in England and Wales with leukaemia. nine weeks after his initial stayed committed to fulfilling Paul’s wish and continuing We receive no government funding diagnosis. His parents Eddie and Marion Jean’s work – to give children and rely on the public for support. 140 were shocked by the news. Before his death, Paul begged with leukaemia a better chance. We are no less determined today 120 They were told, however, that his parents to help other Just a week after Jean’s death, than we were 20 years ago. We want 100 his chances of survival were children with leukaemia in the Eddie and Marion met Diana, all children diagnosed with this killer excellent as a suitable donor hope that some day a cure 80 Princess of Wales. Saddened disease to be cured and for the cure had been found for a bone would be found. 60 and moved by their double to be effected with minimum marrow transplant. disruption to their lives. number of deaths 40 His sister Jean immediately tragedy, she personally helped While waiting for the operation, began a fundraising campaign Ultimately our aim is to understand 20 start this charity, which she Paul contracted a virus and his to honour the promise to Paul inaugurated in January 1988. what causes children to develop the 0 disease, so that the increasing 1999 2000 2001 2002 2003 2004 2005 condition deteriorated. but tragedy would strike the Princess Diana’s commitment incidence of childhood leukaemia Year In the hospital, Paul observed O’Gorman family again. did not stop there. She remained can be halted and reversed. the tremendous suffering other Just nine months after Paul’s supportive of our work until her Source: Office for National Statistics (ONS). own untimely death in 1997. Figures for 2006 and 2007 are not yet available and figures for children with leukaemia endured death, and only days after the Scotland and Northern Ireland are not available from the ONS. and how they managed to cope first major fundraising event, The positive caring spirit of Paul with great courage and Jean died, also of cancer, in and Jean and Princess Diana determination. November 1987, aged 29. continues to inspire our work. Eddie O’Gorman Chairman of the Trustees www.leukaemia.org/about-us 2 CHILDREN with LEUKAEMIA Registered Charity No. 298405. Inaugurated in 1988 by Diana, Princess of Wales in memory of Jean and Paul O’Gorman Review of the year The charity’s own programme of How we performed against our objectives fundraising events was also once again sold out, complemented by a growing body of individuals and organisations now fundraising year ago we set out goals for We prepared, as planned, to Welfare – pages 14 to 16 A on our behalf (see page 21). the following twelve months and launch the next grants round for The relief of children suffering on these pages we set out in research into causes and with leukaemia Beyond our main strands of summary how we have developed the content of the support, our new corporate performed against each of them. 2008 conference on causation partnership team rapidly These achievements are of childhood leukaemia, to be In 2007, we aimed to raise a expanded company support for organised into groups, each held at the Institute of Child further £1 million for the our work (see page 20) and by mid year we succeeded in our headed by the wording of the Health, with Professor Eric expansion of the cancer wards goal of appointing a dedicated relevant charitable