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Home , Naphyrone, Sibutramine, Solriamfetol, Thiafentanil

MISSISSIPPI LEGISLATURE REGULAR SESSION 2021

By: Senator(s) Jordan, Jackson (11th), To: Drug Policy Thomas

SENATE BILL NO. 2278

1 AN ACT TO AMEND SECTION 41-29-113, MISSISSIPPI CODE OF 1972, 2 TO INCLUDE ISOTONITAZENE, FLUALPRAZOLAM, FLUBROMAZEPAM, 3 FLUBROMAZOLAM AND CLONAZOLAM TO SCHEDULE I BECAUSE THESE DRUGS 4 HAVE NO LEGITIMATE MEDICAL USE AND HAVE HIGH POTENCY WITH GREAT 5 POTENTIAL TO CAUSE HARM; TO AMEND SECTION 41-29-115, MISSISSIPPI 6 CODE OF 1972, TO REVISE THE CHEMICAL NAME OF THIAFENTANIL; TO 7 AMEND SECTION 41-29-119, MISSISSIPPI CODE OF 1972, TO INCLUDE 8 BREXANOLONE AND AS SCHEDULE IV CONTROLLED SUBSTANCES 9 BECAUSE THE FEDERAL DRUG ADMINISTRATION RECENTLY APPROVED THESE 10 DRUGS FOR MEDICAL USE; AND FOR RELATED PURPOSES. 11 BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF MISSISSIPPI:

12 SECTION 1. Section 41-29-113, Mississippi Code of 1972, is 13 amended as follows: 14 41-29-113.

15 SCHEDULE I 16 (a) Schedule I consists of the drugs and other substances, 17 by whatever official name, common or usual name, chemical name, or

18 brand name designated, that is listed in this section.

19 (b) Opiates. Unless specifically excepted or unless listed 20 in another schedule, any of the following opiates, including their 21 , esters, ethers, salts and salts of isomers, esters and

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ G1/2 21/SS26/R204.1 PAGE 1 (ens\tb) 22 ethers, whenever the existence of these isomers, esters, ethers 23 and salts is possible within the specific chemical designation: 24 (1) Acetyl-alpha-methylfentanyl; 25 (2) Acetyl 26 N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide; 27 (3) AH-7921 (3,4-dichloro-N-[(1-dimethylamino)

28 cyclohexylmethyl]benzamide); 29 (4) Acetylmethadol; 30 (5) Allylprodine; 31 (6) Alphacetylmethadol, except levo-alphacetylmethadol 32 (levo-alpha-acetylmethadol, levomethadyl acetate, or LAAM); 33 (7) Alphameprodine; 34 (8) Alphamethadol;

35 (9) Alpha-methylfentanyl; 36 (10) Alpha-methylthiofentanyl; 37 (11) Benzethidine; 38 (12) Betacetylmethadol; 39 (13) Beta-hydroxyfentanyl;

40 (14) Beta-hydroxy-3-methylfentanyl; 41 (15) Betameprodine;

42 (16) Betamethadol; 43 (17) Betaprodine; 44 (18) Butyrl fentanyl 45 (N-(1-phenethylpiperidin-4-yl)-N-phenylbutyramide); 46 (19) Clonitazene;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 2 (ens\tb) 47 (20) ; 48 (21) Diampromide; 49 (22) Diethylthiambutene; 50 (23) Difenoxin; 51 (24) ; 52 (25) Dimepheptanol;

53 (26) Dimethylthiambutene; 54 (27) Dioxaphetyl butyrate; 55 (28) ; 56 (29) Ethylmethylthiambutene; 57 (30) Etonitazene; 58 (31) Etoxeridine; 59 (32) Fentanyl-related substances, meaning any substance

60 not otherwise listed under another schedule and for which no 61 exemption or approval is in effect under Section 505 of the 62 Federal Food, Drug, and Cosmetic Act [21 USC 355] that is 63 structurally related to fentanyl by one or more of the following 64 modifications:

65 (A) Replacement of the phenyl portion of the 66 phenethyl group by any monocycle, whether or not further

67 substituted in or on the monocycle; 68 (B) Substitution in or on the phenethyl group with 69 alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino or nitro 70 groups;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 3 (ens\tb) 71 (C) Substitution in or on the ring with 72 alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, 73 amino or nitro groups; 74 (D) Replacement of the aniline ring with any 75 aromatic monocycle whether or not further substituted in or on the 76 aromatic monocycle; and/or

77 (E) Replacement of the N-propionyl group by 78 another acyl group. 79 Fentanyl-related substances include, but are not limited to, 80 cyclopropyl fentanyl, 81 (N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopropanecarboxamide); 82 Furanyl-Fentanyl, 83 (N-(1-phenethylpiperidin-4-yl)-N-phenylfuran-2-carboxamide);

84 valeryl fentanyl, 85 (N-(1-phenethylpiperidin-4-yl)-N-phenylpentanamide); 86 para-fluorobutyryl fentanyl, 87 (N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)butyramide); 88 para-methoxybutyryl fentanyl,

89 (N-(4-methoxyphenyl)-N-(1-phenethylpiperidin-4-yl)butyramide); 90 para-chloroisobutyryl fentanyl,

91 (N-(4-chlorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide); 92 isobutyryl fentanyl, 93 (N-(1-phenethylpiperidin-4-yl)-N-phenylisobutyramide);

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 4 (ens\tb) 94 cyclopentyl fentanyl, 95 (N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopentanecarboxamide); 96 and 97 ocfentanil, 98 (N-(2-fluorophenyl)-2-methoxy-N-(1-phenethylpiperidin-4-yl)acetami 99 de);

100 (33) Furethidine; 101 (34) Hydroxypethidine; 102 (35) Isotonitazene (N,N-diethyl-2-(2-(4 103 isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-yl)ethan-1-);

104 ( * * *36) (including the optical and 105 geometric isomers);

106 ( * * *37) Levomoramide;

107 ( * * *38) Levophenacylmorphan; 108 ( * * *39) 3-methylfentanyl; 109 ( * * *40) 3-methylthiofentanyl; 110 ( * * *41) Morpheridine;

111 ( * * *42) MPPP 112 (1-methyl-4-phenyl-4-propionoxypiperidine);

113 ( * * *43)

114 N-[1-[2-hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylprop 115 ionamide, its isomers, esters, ethers, salts and salts of isomers, 116 esters and ethers (other names: beta-hydroxythiofentanyl);

117 ( * * *44) Noracymethadol; 118 ( * * *45) Norlevorphanol;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 5 (ens\tb) 119 ( * * *46) Normethadone; 120 ( * * *47) Norpipanone; 121 ( * * *48) Para-fluorofentanyl; 122 ( * * *49) PEPAP 123 (1-(-2-phenethyl)-4-phenyl-4-acetoxypiperidine);

124 ( * * *50) Phenadoxone;

125 ( * * *51) Phenampromide; 126 ( * * *52) Phenomorphan; 127 ( * * *53) Phenoperidine; 128 ( * * *54) ; 129 ( * * *55) Proheptazine; 130 ( * * *56) Properidine; 131 ( * * *57) ;

132 ( * * *58) Racemoramide; 133 ( * * *59) ; 134 ( * * *60) ; 135 ( * * *61) Trimeperidine;

136 ( * * *62) U-47700, 137 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide.

138 (c) derivatives. Unless specifically excepted or 139 unless listed in another schedule, any of the following opium 140 derivatives, their salts, isomers and salts of isomers, whenever 141 the existence of these salts, isomers and salts of isomers is 142 possible within the specific chemical designation: 143 (1) Acetorphine;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 6 (ens\tb) 144 (2) ; 145 (3) ; 146 (4) methylbromide; 147 (5) Codeine-N-Oxide; 148 (6) ; 149 (7) ;

150 (8) ; 151 (9) Drotebanol; 152 (10) (except hydrochloride salt); 153 (11) ; 154 (12) ; 155 (13) Methyldesorphine; 156 (14) Methyldihydromorphine;

157 (15) Monoacetylmorphine; 158 (16) methylbromide; 159 (17) Morphine methylsulfonate; 160 (18) Morphine-N-Oxide; 161 (19) Myrophine;

162 (20) ; 163 (21) ;

164 (22) Normorphine; 165 (23) Pholcodine; 166 (24) Thebacon.

167 (d) Hallucinogenic substances. Unless specifically excepted 168 or unless listed in another schedule, any material, compound,

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 7 (ens\tb) 169 mixture or preparation which contains any quantity of the 170 following substances, their salts, isomers (whether optical, 171 positional, or geometric) and salts of isomers, whenever the 172 existence of these salts, isomers and salts of isomers is possible 173 within the specific chemical designation: 174 (1) Alpha-ethyltryptamine;

175 (2) 4-bromo-2,5-dimethoxy-; 176 (3) 4-bromo-2,5-dimethoxyphenethylamine; 177 (4) 2,5-; 178 (5) 2,5-dimethoxy-4-ethylamphetamine (DOET); 179 (6) 2,5-dimethoxy-4-(n)-propylthiophenethylamine 180 (-T-7); 181 (7) 4-methoxyamphetamine;

182 (8) 5-methoxy-3,4-methylenedioxy-amphetamine; 183 (9) 4-methyl-2,5-dimethoxy-amphetamine; 184 (10) 3,4-methylenedioxy amphetamine; 185 (11) 3,4-methylenedioxymethamphetamine (MDMA); 186 (12) 3,4-methylenedioxy-N-ethylamphetamine (also known

187 as N-ethyl-alpha-methyl-3,4(methylenedioxy), N-ethyl 188 MDA, MDE, MDEA);

189 (13) N-hydroxy-3,4-methylenedioxyamphetamine (also 190 known as N-hydroxy MDA, N-OHMDA, and 191 N-hydroxy-alpha-methyl-3,4(methylenedioxy)phenethylamine); 192 (14) 3,4,5-trimethoxy amphetamine; 193 (15) 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT);

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 8 (ens\tb) 194 (16) Alpha-methyltryptamine (also known as AMT); 195 (17) Bufotenine; 196 (18) Diethyltryptamine; 197 (19) Dimethyltryptamine; 198 (20) 5-methoxy-N,N- (5-MeO-DIPT); 199 (21) ;

200 (22) Lysergic acid diethylamide (LSD); 201 (23) (A) Marijuana (Hemp as defined and regulated 202 under Sections 69-25-201 through 69-25-221 and 203 contained in a legend drug product approved by the Federal Food 204 and Drug Administration or obtained under Section 41-29-136 are 205 exempt under Schedule I); 206 (B) Hashish;

207 (24) ; 208 (25) Parahexyl; 209 (26) Peyote; 210 (27) N-ethyl-3-piperidyl benzilate; 211 (28) N-methyl-3-piperidyl benzilate;

212 (29) Psilocybin; 213 (30) Psilocyn;

214 (31) , meaning 215 tetrahydrocannabinols contained in a plant of the genus Cannabis 216 (cannabis plant), as well as the synthetic equivalents of the 217 substances contained in the cannabis plant, or in the resinous 218 extractives of such plant, and/or synthetic substances,

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 9 (ens\tb) 219 derivatives, and their isomers with similar chemical structure and 220 pharmacological activity to those substances contained in the 221 plant such as the following: 222 (A) 1 cis or trans ; 223 (B) 6 cis or trans tetrahydrocannabinol; 224 (C) 3,4 cis or trans tetrahydrocannabinol.

225 (Since nomenclature of these substances is not 226 internationally standardized, compounds of these structures, 227 regardless of atomic positions, are covered.) 228 ("Tetrahydrocannabinols" excludes dronabinol and nabilone.) 229 For purposes of this paragraph, tetrahydrocannabinols do not 230 include hemp or hemp products regulated under Sections 69-25-201 231 through 69-25-221.

232 However, the following products are exempted from control: 233 (i) THC-containing industrial products made 234 from cannabis stalks (e.g., paper, rope and clothing); 235 (ii) Processed cannabis plant materials used 236 for industrial purposes, such as fiber retted from cannabis stalks

237 for use in manufacturing textiles or rope; 238 (iii) Animal feed mixtures that contain

239 sterilized cannabis seeds and other ingredients (not derived from 240 the cannabis plant) in a formula designed, marketed and 241 distributed for nonhuman consumption; 242 (iv) Personal care products that contain oil 243 from sterilized cannabis seeds, such as shampoos, soaps, and body

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 10 (ens\tb) 244 lotions (if the products do not cause THC to enter the human 245 body); 246 (v) Hemp as regulated under Sections 247 69-25-201 through 69-25-221; and 248 (vi) Any product derived from the hemp plant 249 designed for human ingestion and/or consumption that is approved

250 by the Food and Drug Administration; 251 (32) ; 252 (33) Ethylamine analog of phencyclidine (PCE); 253 (34) analog of phencyclidine (PHP, PCPy); 254 (35) Thiophene analog of phencyclidine; 255 (36) 1-[1-(2-thienyl)cyclohexyl] pyrrolidine (TCPy); 256 (37) 4-methylmethcathinone ();

257 (38) 3,4-methylenedioxypyrovalerone (MDPV); 258 (39) 2-(2,5-dimethoxy-4-ethylphenyl)ethanamine (2C-E); 259 (40) 2-(2,5-dimethoxy-4-methylphenyl)ethanamine (2C-D); 260 (41) 2-(4-chloro-2,5-dimethoxyphenyl)ethanamine (2C-C); 261 (42) 2-(4-iodo-2,5-dimethoxyphenyl)ethanamine (2C-I);

262 or 2,5-dimethoxy-4-iodophenethylamine; 263 (43) 2-[4-(ethylthio)-2,5-dimethoxyphenyl]ethanamine

264 (2C-T-2); 265 (44) 266 2-[4-(isopropylthio)-2,5-dimethoxyphenyl]ethanamine (2C-T-4); 267 (45) 2-(2,5-dimethoxyphenyl)ethanamine (2C-H); 268 (46) 2-(2,5-dimethoxy-4-nitro-phenyl)ethanamine (2C-N);

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 11 (ens\tb) 269 (47) 2-(2,5-dimethoxy-4-(n)-propylphenyl)ethanamine 270 (2C-P); 271 (48) 3,4-methylenedioxy-N-methylcathinone(); 272 (49) 273 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine 274 (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36);

275 (50) 276 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine 277 (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82); 278 (51) 279 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine or 280 N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; 281 Cimbi-5);

282 (52) 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1, 283 4-benzodiazepin-2-one (also known as Phenazepam); 284 (53) 7-(2-chlorophenyl)-4-ethyl-13-methyl-3-thia-1,8, 285 11,12-tetraazatricyclo[8.3.0.0]trideca-2(6),4,7,10,12-pentaene 286 (also known as Etizolam);

287 (54) ; 288 (55) Synthetic cannabinoids. Unless specifically

289 excepted or unless listed in another schedule, any material, 290 compound, mixture, or preparation which contains any quantity of a 291 synthetic cannabinoid found in any of the following chemical 292 groups, whether or not substituted to any extent, or any of those 293 groups which contain any synthetic cannabinoid salts, isomers, or

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 12 (ens\tb) 294 salts of isomers, whenever the existence of such salts, isomers, 295 or salts of isomers is possible within the specific chemical 296 designation, including all synthetic cannabinoid chemical 297 analogues in such groups: 298 (A) (6aR,10aR)-9-(hydroxymethyl)-6, 299 6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]

300 chromen-1-ol (also known as HU-210 or 301 1,1-dimethylheptyl-11-hydroxy-delta8-tetrahydrocannabinol); 302 (B) Naphthoylindoles and naphthylmethylindoles, 303 being any compound structurally derived from 3-(1-naphthoyl)indole 304 or 1H-indol-3-yl-(1-naphthyl)methane, whether or not substituted 305 in the indole ring to any extent, or in the naphthyl ring to any 306 extent;

307 (C) Naphthoylpyrroles, being any compound 308 structurally derived from 3-(1-naphthoyl)pyrrole, whether or not 309 substituted in the pyrrole ring to any extent, or in the naphthyl 310 ring to any extent; 311 (D) Naphthylmethylindenes, being any compound

312 structurally derived from 1-(1-naphthylmethyl)indene, whether or 313 not substituted in the indene ring to any extent or in the

314 naphthyl ring to any extent; 315 (E) Phenylacetylindoles, being any compound 316 structurally derived from 3-phenylacetylindole, whether or not 317 substituted in the indole ring to any extent or in the phenyl ring 318 to any extent;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 13 (ens\tb) 319 (F) Cyclohexylphenols, being any compound 320 structurally derived from 2-(3-hydroxycyclohexyl)phenol, whether

321 or not substituted in the cyclohexyl ring to any extent or in the 322 phenolic ring to any extent; 323 (G) Benzoylindoles, whether or not substituted in 324 the indole ring to any extent or in the phenyl ring to any extent;

325 (H) Adamantoylindoles, whether or not substituted 326 in the indole ring to any extent or in the adamantoyl ring system 327 to any extent; 328 (I) Tetrahydro derivatives of cannabinol and 329 3-alkyl homologues of cannabinol or of its tetrahydro derivatives, 330 except where contained in cannabis or cannabis resin; 331 (J) 3-Cyclopropylmethanone indole or

332 3-Cyclobutylmethanone indole or 3-Cyclopentylmethanone indole by 333 substitution at the nitrogen atom of the indole ring, whether or 334 not further substituted in the indole ring to any extent, whether 335 or not substituted on the cyclopropyl, cyclobutyl or cyclopentyl 336 rings to any extent;

337 (K) Quinolinyl ester indoles, being any compound 338 structurally derived from 1H-indole-3carboxylic acid-8-quinolinyl

339 ester, whether or not substituted in the indole ring to any extent 340 or the quinolone ring to any extent; 341 (L) 3-carboxamide-1H-indazoles, whether or not 342 substituted in the indazole ring to any extent and substituted to 343 any degree on the carboxamide nitrogen and

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 14 (ens\tb) 344 3-carboxamide-1H-indoles, whether or not substituted in the indole 345 ring to any extent and substituted to any degree on the 346 carboxamide nitrogen; 347 (M) Cycloalkanemethanone Indoles, whether or not 348 substituted at the nitrogen atom on the indole ring, whether or 349 not further substituted in the indole ring to any extent, whether

350 or not substituted on the cycloalkane ring to any extent.

351 (e) Depressants. Unless specifically excepted or unless 352 listed in another schedule, any material, compound, mixture, or 353 preparation which contains any quantity of the following 354 substances having a depressant effect on the central nervous 355 system, including their salts, isomers, and salts of isomers, 356 whenever the existence of such salts, isomers, and salts of

357 isomers is possible within the specific chemical designation: 358 (1) Clonazolam, 359 6-(2-chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4] 360 benzodiazepine; 361 (2) Flualprazolam,

362 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4 363 ]benzodiazepine;

364 (3) Flubromazepam, 365 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 366 (4) Flubromazolam, 367 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4] 368 benzodiazepin;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 15 (ens\tb) 369 ( * * *5) Gamma-hydroxybutyric acid (other names 370 include: GHB, gamma-hydroxybutyrate; 4-hydroxybutyrate; 371 4-hydroxybutanoic acid; ; sodium oxybutyrate);

372 ( * * *6) Mecloqualone; 373 ( * * *7) Methaqualone. 374 (f) . Any material, compound, mixture or 375 preparation which contains any quantity of the following central 376 nervous system stimulants including optical salts, isomers and 377 salts of isomers unless specifically excepted or unless listed in 378 another schedule: 379 (1) ; 380 (2) N- (also known as BZP and 381 1-benzylpiperazine);

382 (3) ; 383 (4) ; 384 (5) ; 385 (6) 4-methylaminorex (also known as 386 2-amino-4-methyl-5-phenyl-2-);

387 (7) N-ethylamphetamine; 388 (8) Any material, compound, mixture or preparation

389 which contains any quantity of N,N-. (Other 390 names include: N,N,-alpha-trimethyl-benzeneethanamine and 391 N,N-alpha-trimethylphenethylamine);

392 (9) Synthetic . (A) Unless listed in 393 another schedule, any compound other than that is

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 16 (ens\tb) 394 structurally derived from 2-Amino-1-phenyl-1-propanone by 395 modification in any of the following ways: 396 (i) By substitution in the phenyl ring to any 397 extent with alkyl, alkoxy, alkylenedioxy, haloalkyl or halide 398 substituents, whether or not further substituted in the phenyl 399 ring by one or more other univalent substituents;

400 (ii) By substitution at the 3-position with 401 an alkyl substituent; 402 (iii) By substitution at the nitrogen atom 403 with alkyl or dialkyl groups, or by inclusion of the nitrogen atom 404 in a cyclic structure. 405 (B) The compounds covered in this paragraph (9) 406 include, but are not limited to, any material, compound, mixture

407 or preparation which contains any quantity of a synthetic 408 cathinone found in any of the following compounds, whether or not 409 substituted to any extent, or any of these compounds which contain 410 any synthetic cathinone, or salts, isomers, or salts of isomers, 411 whenever the existence of such salts, isomers or salts of isomers

412 is possible, unless specifically excepted or listed in another 413 schedule:

414 (i) 4-methyl-N-ethylcathinone ("4-MEC"); 415 (ii) 4-methyl-alpha-pyrrolidinopropiophenone 416 ("4-MePPP"); 417 (iii) Alpha-pyrrolidinopentiophenone 418 ("α-PVP");

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 17 (ens\tb) 419 (iv) 420 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one (""); 421 (v) 2-(methylamino)-1-phenylpentan-1-one 422 (""); 423 (vi) 424 1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one

425 (""); 426 (vii) 4-fluoro-N-methylcathinone ("4-FMC"); 427 (viii) 3-fluoro-N-methylcathinone ("3-FMC"); 428 (ix) 429 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one (""); 430 (x) Alpha-pyrrolidinobutiophenone ("α-PBP"); 431 and

432 (xi) 433 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-pentan-1-one 434 (N-ethylpentylone, ephylone).

435 SECTION 2. Section 41-29-115, Mississippi Code of 1972, is 436 amended as follows:

437 41-29-115. (a) The controlled substances listed in this 438 section, by whatever official name, common or usual name, chemical

439 name, or brand name designated, are included in Schedule II.

440 SCHEDULE II 441 (b) Substances, vegetable origin or chemical synthesis. 442 Unless specifically excepted or unless listed in other schedules, 443 any of the following substances, whether produced directly or

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 18 (ens\tb) 444 indirectly by extraction from substances of vegetable origin, or 445 independently by means of chemical synthesis, or by combination of 446 extraction and chemical synthesis: 447 (1) Opium and opiate, and any salt, compound, 448 derivative, or preparation of opium or opiate, excluding 449 apomorphine, -derived , ,

450 , , , , and 451 , but including the following: 452 (i) Codeine; 453 (ii) ; 454 (iii) ; 455 (iv) Etorphine hydrochloride; 456 (v) Granulated opium;

457 (vi) , whether alone or in combination 458 with any material, compound, mixture or preparation; 459 (vii) ; 460 (viii) ; 461 (ix) Morphine;

462 (x) Opium extracts; 463 (xi) Opium fluid extracts;

464 (xii) ; 465 (xiii) ; 466 (xiv) ; 467 (xv) Powdered opium; 468 (xvi) Raw opium;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 19 (ens\tb) 469 (xvii) Thebaine; 470 (xviii) Tincture of opium; 471 (2) Any salt, compound, , derivative, or 472 preparation thereof which is chemically equivalent or identical 473 with any of the substances referred to in paragraph (1), but not 474 including the isoquinoline alkaloids of opium;

475 (3) Opium poppy and poppy straw; 476 (4) leaves and any salt, compound, derivative, or 477 preparation of or coca leaves, including cocaine and 478 ecgonine and any salt, compound, derivative, isomer, or 479 preparation thereof which is chemically equivalent or identical 480 with any of these substances, but not including: 481 (i) Decocainized coca leaves or extraction of coca

482 leaves, which extractions do not contain cocaine or ecgonine; or 483 (ii) ; 484 (5) Concentrate of poppy straw (the crude extract of 485 poppy straw in either liquid, solid or powder form which contains 486 the phenanthrene alkaloids of the opium poppy).

487 (c) Opiates. Any of the following opiates, including their 488 isomers, esters, ethers, salts, and salts of isomers, whenever the

489 existence of these isomers, esters, ethers and salts is possible 490 within the specified chemical designation, dextrorphan and 491 levopropoxyphene excepted: 492 (1) ; 493 (2) Alphaprodine;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 20 (ens\tb) 494 (3) ; 495 (4) ; 496 (5) Bulk (nondosage forms); 497 (6) ; 498 (7) ; 499 (8) ;

500 (9) Fentanyl; 501 (10) ; 502 (11) Levo-alphacetylmethadol 503 (levo-alpha-acetylmethadol, levomethadyl acetate, LAAM); 504 (12) ; 505 (13) ; 506 (14) ;

507 (15) ; 508 (16) Methadone-intermediate, 509 4-cyano-2-dimethylamino-4,4-diphenyl butane; 510 (17) Moramide-intermediate, 511 2-methyl-3-morpholino-1,1-diphenylpropane-carboxylic acid;

512 (18) (meperidine); 513 (19) Pethidine-Intermediate-A,

514 4-cyano-1-methyl-4-phenylpiperidine; 515 (20) Pethidine-Intermediate-B, 516 ethyl-4-phenylpiperidine-4-carboxylate; 517 (21) Pethidine-Intermediate-C, 518 1-methyl-4-phenylpiperidine-4-carboxylic acid;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 21 (ens\tb) 519 (22) ; 520 (23) ; 521 (24) Racemethorphan; 522 (25) ; 523 (26) ; 524 (27) ;

525 (28) ;

526 (29) Thiafentanil, * * * methyl 527 4-(2-methoxy-N-phenylacetamido)-1-(2-(thiophen-2-yl)ethyl)piperidi 528 ne-4-carboxylate).

529 (d) Stimulants. Any material, compound, mixture, or 530 preparation which contains any quantity of the following 531 substances:

532 (1) Amphetamine, its salts, optical isomers, and salts 533 of its optical isomers; 534 (2) and its salts; 535 (3) Any substance which contains any quantity of 536 , including its salts, isomers, and salts of

537 isomers; 538 (4) and its salts;

539 (5) , its salts, isomers and salts of 540 isomers.

541 (e) Depressants. Unless specifically exempted or unless 542 listed in another schedule, any material, compound, mixture, or

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 22 (ens\tb) 543 preparation which contains any quantity of the following 544 substances: 545 (1) Amobarbital; 546 (2) Secobarbital; 547 (3) Pentobarbital; 548 (4) Glutethimide.

549 (f) Hallucinogenic substances. 550 (1) Dronabinol oral solution 551 [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)]; 552 (2) Nabilone [other names include: 553 (+/-)-trans-3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a- 554 hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo(b,d)pyran-9-one].

555 (g) Immediate precursors. Unless specifically excepted or 556 unless listed in another schedule, any material, compound, 557 mixture, or preparation which contains any quantity of the 558 following substances: 559 (1) Amphetamine and methamphetamine immediate 560 precursor: Phenylacetone (other names include:

561 phenyl-2-propanone; P2P; benzyl methyl ketone; and methyl benzyl 562 ketone);

563 (2) Phencyclidine immediate precursors: 564 (i) 1-phenylcyclohexylamine; 565 (ii) 1-piperidinocyclohexanecarbonitrile (PCC); 566 (3) Fentanyl immediate precursor: 567 4-anilino-N-phenethyl-4-piperidine (ANPP).

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 23 (ens\tb) 568 (h) Any material, compound, mixture or preparation which 569 contains any quantity of a Schedule II controlled substance and is 570 listed as an exempt substance in 21 CFR, Section 1308.24 or 571 1308.32, shall be exempted from the provisions of the Uniform 572 Controlled Substances Law.

573 SECTION 3. Section 41-29-119, Mississippi Code of 1972, is 574 amended as follows: 575 41-29-119. (A) The controlled substances listed in this 576 section are included in Schedule IV.

577 SCHEDULE IV 578 (a) Narcotic drugs. Unless specifically excepted or 579 unless listed in another schedule, any material, compound, mixture 580 or preparation which contains limited quantities of the following

581 narcotic drugs, or any salts thereof: 582 (1) Not more than one (1) milligram of difenoxin 583 and not less than twenty-five (25) micrograms of atropine sulfate 584 per dosage unit; 585 (2) Dextropropoxyphene, including its salts

586 (Darvon, Darvon-N; also found in Darvon compound and Darvocet-N, 587 etc.);

588 (3) 589 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol, its 590 salts, optical and geometric isomers and salts of these isomers 591 (including ).

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 24 (ens\tb) 592 (b) Depressants. Any material, compound, mixture or 593 preparation which contains any quantity of the following 594 substances: 595 (1) Alfaxalone; 596 (2) Alprazolam; 597 (3) Barbital;

598 (4) Brexanolone;

599 ( * * *5) Bromazepam; 600 ( * * *6) Camazepam; 601 ( * * *7) Carisoprodol; 602 ( * * *8) Chloral betaine; 603 ( * * *9) Chloral hydrate; 604 ( * * *10) Chlordiazepoxide and its salts, but 605 does not include chlordiazepoxide hydrochloride and clidinium 606 bromide or chlordiazepoxide and esterified estrogens;

607 ( * * *11) Clobazam; 608 ( * * *12) Clonazepam;

609 ( * * *13) Clorazepate;

610 ( * * *14) Clotiazepam; 611 ( * * *15) Cloxazolam;

612 ( * * *16) Delorazepam; 613 ( * * *17) Diazepam; 614 ( * * *18) Dichloralphenazone; 615 ( * * *19) Estazolam; 616 ( * * *20) Ethchlorvynol;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 25 (ens\tb) 617 ( * * *21) Ethinamate; 618 ( * * *22) Ethyl loflazepate; 619 ( * * *23) Fludiazepam; 620 ( * * *24) Flunitrazepam; 621 ( * * *25) Flurazepam; 622 ( * * *26) Fospropofol;

623 ( * * *27) Halazepam; 624 ( * * *28) Haloxazolam; 625 ( * * *29) Ketazolam; 626 ( * * *30) Loprazolam; 627 ( * * *31) Lorazepam; 628 ( * * *32) Lormetazepam; 629 ( * * *33) Mebutamate;

630 ( * * *34) Medazepam; 631 ( * * *35) Meprobamate; 632 ( * * *36) Methohexital; 633 ( * * *37) Methylphenobarbital;

634 ( * * *38) Midazolam;

635 ( * * *39) Nimetazepam; 636 ( * * *40) Nitrazepam;

637 ( * * *41) Nordiazepam; 638 ( * * *42) Oxazepam; 639 ( * * *43) Oxazolam; 640 ( * * *44) Paraldehyde; 641 ( * * *45) Petrichloral;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 26 (ens\tb) 642 ( * * *46) Phenobarbital; 643 ( * * *47) Pinazepam; 644 ( * * *48) Prazepam; 645 ( * * *49) Quazepam; 646 ( * * *50) Suvorexant; 647 ( * * *51) Temazepam;

648 ( * * *52) Tetrazepam; 649 ( * * *53) Triazolam; 650 ( * * *54) Zaleplon; 651 ( * * *55) Zolpidem; 652 ( * * *56) Zopiclone. 653 (c) .

654 (d) . Any material, compound, mixture, or 655 preparation which contains any quantity of Lorcaserin, including 656 its salts, isomers, and salts of such isomers, whenever the 657 existence of such salts, isomers, and salts of isomers is 658 possible.

659 (e) Stimulants. Any material, compound, mixture or 660 preparation which contains any quantity of the following 661 substances:

662 (1) ((+/-) Norpseudoephedrine); 663 (2) Diethylpropion; 664 (3) ; 665 (4) ; 666 (5) ;

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 PAGE 27 (ens\tb) 667 (6) ; 668 (7) ; 669 (8) (including any organometallic 670 complexes and chelates thereof); 671 (9) ; 672 (10) ;

673 (11) ; 674 (12) Solriamfetol;

675 ( * * *13) SPA 676 ((-)-1-dimethylamino-1,2-diphenylethane).

677 (f) Other substances. 678 (1) ; 679 (2) Butorphanol (including its optical isomers);

680 (3) 681 (5-[[[(2S)-2-amino-3-[4-aminocarbonyl)-2,6-dimethylphenyl]-1-oxopr 682 opyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-meth 683 oxybenzoic acid); (including its optical isomers) and its salts, 684 isomers, and salts of isomers.

685 (B) Any material, compound, mixture or preparation which 686 contains any quantity of a Schedule IV controlled substance and is

687 listed as an exempt substance in 21 CFR, Section 1308.22, 1308.24, 688 1308.26, 1308.32 or 1308.34, shall be exempted from the provisions 689 of the Uniform Controlled Substances Law.

690 SECTION 4. This act shall take effect and be in force from 691 and after July 1, 2021.

S. B. No. 2278 *SS26/R204.1* ~ OFFICIAL ~ 21/SS26/R204.1 ST: Uniform Controlled Substances Act; revise PAGE 28 (ens\tb) schedules.