DOCSLIB.ORG

Data Dictionary PSHU List SEP 2018

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) 20 Pharmaceutical Substance For Human Use Description (Multi-) Vitamin With Iron (Multi-) Vitamin Without Iron 11-Nor Tetrahydrocannabinol-9-Carboxylic Acid 1BZP 2C-B 2CD 2C-E 2C-I 2C-P 3, 4-Methylenedioxyamphetamine 3,4-Methylenedioxymethylamphetamine 4-Methoxyamphetamine 5,6-methylenedioxy-2-aminoindane 5F(x) 6-Monoacetyl Morphine 7-Aminoclonazepam 7-Aminoflunitrazepam 7-Aminonitrazepam 9Tetrahydrocannabinol (THC) 9Tetrahydrocannabinol-9-Carboxylic Acid Acetazolamide Acetylfentanyl Acne Preparation Adrenaline Alcohol Alcohol (Ethanol) Allopurinol Alprazolam AM drugs Amantadine Aminoclonazepam Aminoflunitrazepam Aminoindanes Aminonitrazepam Aminophylline Amiodarone Amisulpride Amitriptyline Amlodipine Amoxicillin Amoxil Amoxycillin Amphetamine Amphetamine, Methamphetamine, Methylamphetamine Ampicillin Amylobarbitone Anabolic steroids Antibacterial Agent Containing Aminoglycosides Antibacterial Agent Containing Cephalosporins and Other Beta-Lactam Antibiotics Antibacterial Agent Containing Macrolides NCIS Data Dictionary – Version 3(Revised), September 2018 Pharmaceutical Substance Codeset 1 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Antibacterial Agent Containing Penicillin Antibacterial Agent Containing Rifamycins Antibacterial Agent Containing Substance from Chloramphenicol Group Antibacterial Agent Containing Tetracycline Antigonadatrophin, Anti-oestrogen, Antiandrogen Preparation Antimycobacterial Drugs Anti-Parasitic Agent a-PVP Aripiprazole Aspirin Atenolol Atomoxetine Atorvastatin Atracurium Atropine Augmentin Azithromycin Baclofen Bactrim Barbitone Bathsalts Benzatropine Benzhexol Benzodiazepines, nec Benzoylecgonine Benztropine Benzylpenicillin Benzylpiperazine Beta Blocker Bisoprolol Black Mamba Bleomycin Boric Acid, Borate Bromazepam Bromo-Dragonfly Brompheniramine Bupivacaine Buprenorphine Bupropion Butobarbital Butobarbitone Butylone Caffeine Calamine Lotion Calcium Camphor/Methyl Salicylate Cannabinoids Cannabis Carbamazepine Carbidopa Carboplatin Carboxytetrahydrocannabinol C-drugs 2 Pharmaceutical Substance Codeset NCIS Data Dictionary – Version 3(Revised), September 2018 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Cefaclor Cefazolin Ceftriaxone Celecoxib Cephalexin Cephazolin Cetirizine Chloral Hydrate Chloroquine Chlorpheniramine Chlorpromazine CHMINACA Ciprofloxacin Citalopram Clarithromycin Clexane Clindamycin Clobazam Clockwork Orange Clomipramine Clonazepam Clonidine Clopidogrel Clozapine Cocaethylene Cocaine Codeine Codeine (Free) Codeine (Total) Codeine Glucuronide Codeine-6-Glucuronide Colchicine Corticosteroids Cotinine Cyclizine Cyproheptadine Delta-9-Tetrahydrocannabinol Delta-9-THC Desacetyldiltiazem Desipramine Desmethylcitalopram Desmethyldiazepam Desmethylsertraline Desmethyltramadol Desmethylvenlafaxine Detoxifying Agent, Antidote Dexamphetamine Dextroamphetamine Dextromethorphan Dextropropoxyphene Diamox Diazepam Diclofenac NCIS Data Dictionary – Version 3(Revised), September 2018 Pharmaceutical Substance Codeset 3 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Diet Aid Digoxin Dihydrocodeine Diltiazem Dimethyltryptamine Diphenhydramine Diphenoxylate Dipyridamole Disopyramide Disulfiram DMT Dothiepin Doxepin Doxorubicin Doxycycline Doxylamine Duloxetine Ecstasy Electrolytes Enoxaparin Ephedrine Epinephrine Ergot Alkaloid Ertapenem Erythromycin Escitalopram Esomeprazole Ethanol Etizolam Felodipine Fentanyl Flakka Flecainide Flephedrone Flucloxacillin Fluconazole Flunitrazepam Fluoride Fluoxetine Flupenthixol Flupentixol Fluphenazine Fluticasone Fluvoxamine Fluxonazole Frusemide FUBINACA Furanyl fentanyl Gabapentin Gamma Hydroxybutrate Gentamicin GHB Gliclazide 4 Pharmaceutical Substance Codeset NCIS Data Dictionary – Version 3(Revised), September 2018 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Glucagon Glucocorticoids Guaifenesin Haloperidol Heparin Heroin and Metabolites Hydrochlorothiazide Hydrocodone Hydromorphone Hydroxyalprazolam Hydroxybupropion Hydroxychloroquine Hyoscine Ibogaine Ibuprofen Imipramine Immunomodulating Preparation Immunosuppressant Drugs Indapamide Indomethacin Influenza Drugs Insulin Iodine or Iodide Antiseptic Irbesartan Iron JWH drugs JWH-x K2 Kava Kavain Keflex Ketamine Ketoprofen Kronic Lamotrigine Lansoprazole Laudanosine L-dopa or Related Drug Lenalidomide Levamisole Levetiracetam Levodopa Levomepromazine Lignocaine Lithium Loperamide Loratadine Lorazepam Lozenges With or Without Local Anaesthetic for Throat LSD Lysergic acid diethylamide Magic Mushrooms Marijuana NCIS Data Dictionary – Version 3(Revised), September 2018 Pharmaceutical Substance Codeset 5 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Marijuana, Cannabis mCPP MDA MDAI MDEA MDMA MDPV Meloxicam Meow Meow Mephedrone Mesoridazine Metformin Methadone Methamphetamine Methanol Methlyendeioxymethylamphetamine Methorphan Methotrexate Methylamphetamine Methylecgonine Methylenedioxyamphetamine Methylenedioxymethylamphetamine Methylphenidate Metoclopramide Metoprolol Metronidazole Mianserin Midazolam Mirtazapine Moclobemide Modafinil Monoacetylmorphine Morphine (Free) Morphine and Metabolites Morphine Glucuronides Morphine Total Morphine-3-Glucuronide Morphine-6-Glucuronide MT-45 Naloxone Naltrexone Nandrolone Naproxen NBOMe Nefazodone Neomycin Nicotine Nifedipine Nitrazepam Nitroglycerin Nitrous Oxide N-methoxybenzyl Noradrenaline 6 Pharmaceutical Substance Codeset NCIS Data Dictionary – Version 3(Revised), September 2018 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Norbuprenorphine Norcitalopram Norclozapine Nordiazepam Nordoxepin Norephedrine Norepinephrine Norfentanyl Norfloxacin Norfluoxetine Norolanzapine Noroxycodone Norpethidine Norpropoxyphene Norpseudoephedrine Norsertraline Nortriptyline Norvenlafaxine O-Desmethyltramadol O-Desmethylvenlafaxine Olanzapine Omeprazole Ondansetron Opioid Opioids (not classified) Oral or Injectable Contraceptive Orphenadrine Other ACE Inhibitors Other Addictive Disorder Drugs Other Alpha Adrenergic Blockers Other Anaesthetics Other Analgesics Other Antacids, Antiflatulents, Drug for Treatment of Peptic Ulcers Other Antiangina Agents Other Antiarrhythmics Other Anticoagulants Other Anticonvulsants Other Antidepressant and Antipsychotics Other Antidiabetics Other Antidiarrhoeals, Intestinal Anti-inflammatories, Intestinal Anti-infective Agents Other Antidotes Other Anti-emetic, Anti-nauseant Preparations Other Antifungal Agents Other Anti-Haemorrhagics Other Anti-Helmintics Other Antihistamines Other Antihypertensive Other Anti-Malarial Drugs Other Antimicrobial, Anti-Infective Agents Other Anti-Neoplastic Agents Other Antiplatelet Drug Other Anti-Protozoal Drugs Other Antiretroviral Drugs NCIS Data Dictionary – Version 3(Revised), September 2018 Pharmaceutical Substance Codeset 7 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Other Antispasmodics, Propulsives Other Anti-Thrombotic Other Antituberculotic, Antileprotic Agents Other Antiviral Agent Other Aromatase Inhibitors Other Atypical Antipsychotics Other Barbiturates Other Beta-2 Antagonist Other Calcium Channel Blockers Other Cancer Medication Other Cannabinoids and Related Drugs Other Cardiovascular Drugs Other Chemotherapy Agents Other Cholinergic and anticholinergic agents Other Cholinesterase Inhibitors Other Coagulants Other Cold and Cough Decongestants Other Cold and Cough Expectorants Other Cold and Cough Preparations Other Dermatological Agents Other Diagnostic Agents Other Diuretics Other Drugs for Obstructive Airway Diseases Other Drugs of Systemic Effects Other Electrolytes or Minerals Other Eugeroics Other Eye/Ear/Nose/Throat Preparations Other Fibrates Other Gastric Reflux Medications Other Gastrointestinal Preparations Other Hormone Agents Other Hyperkinetic Treatments Other Inhalation Anaesthetics Other Intravenous Anaesthetics Other Laxatives Other Local and Topical Anaesthetics Other Migraine Analgesics Other Miscellaneous Drugs Of Concern Other Mood Stabilisers Other Muscle Relaxants and Anti-Spastics Other Nicotine Pharmaceutical Other Nitrates Other Nonsteroidal Anti-inflammatory Agents (NSAIDS) Other Novel Psychoactive Substances Other NRIs/SNRIs Other Organic Opioid Analgesics Other Respiratory Drugs Other RIMA Inhibitors Other Sedatives and Hypnotics Other Selective Serotonin Receptor Inhibitor (SSRI) Other Semisynthetic Opioid Analgesics Other Serotonin Modulators Other Serums, Toxoids, Vaccines 8 Pharmaceutical Substance Codeset NCIS Data Dictionary – Version 3(Revised), September 2018 NCIS Pharmaceutical Substance Codeset – Full Substance List (No Categories) Other Steroids Other Stimulants And Hallucinogens Other Sulfonylureas Other Synthetic Opioid Analgesics Other Therapeutic Gases Other Thienodiazepine Other Tricyclic Antidepressants Other Typical Antipsychotics Other Urological Agents Oxazepam Oxcarbazepine Oxybutynin Oxycodone Oxycontin Oxymorphone Paliperidone Panadeine Forte (Codeine) Panadeine Forte (Paracetamol) Pantoprazole Paracetamol Paramethoxyamphetamine Paramethoxymethamphetamine Paroxetine PCP Penicillin Pentamidine Pentobarbital Pentobarbitone Periciazine Pericyazine Perindopril Perindoprilat Pethidine Phencyclidine Pheniramine Phenobarbitone Phenothiazine Phentermine Phenylethylamines Phenytoin Pholcodine PINACA Piperazines Piroxicam Pizotifen PMA Podophyllin Polymyxin Poppy
Recommended publications
  • Guidelines for the Forensic Analysis of Drugs Facilitating Sexual Assault and Other Criminal Acts

    Guidelines for the Forensic Analysis of Drugs Facilitating Sexual Assault and Other Criminal Acts

    Vienna International Centre, PO Box 500, 1400 Vienna, Austria Tel.: (+43-1) 26060-0, Fax: (+43-1) 26060-5866, www.unodc.org Guidelines for the Forensic analysis of drugs facilitating sexual assault and other criminal acts United Nations publication Printed in Austria ST/NAR/45 *1186331*V.11-86331—December 2011 —300 Photo credits: UNODC Photo Library, iStock.com/Abel Mitja Varela Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Guidelines for the forensic analysis of drugs facilitating sexual assault and other criminal acts UNITED NATIONS New York, 2011 ST/NAR/45 © United Nations, December 2011. All rights reserved. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. List of abbreviations . v Acknowledgements .......................................... vii 1. Introduction............................................. 1 1.1. Background ........................................ 1 1.2. Purpose and scope of the manual ...................... 2 2. Investigative and analytical challenges ....................... 5 3 Evidence collection ...................................... 9 3.1. Evidence collection kits .............................. 9 3.2. Sample transfer and storage........................... 10 3.3. Biological samples and sampling ...................... 11 3.4. Other samples ...................................... 12 4. Analytical considerations .................................. 13 4.1. Substances encountered in DFSA and other DFC cases .... 13 4.2. Procedures and analytical strategy...................... 14 4.3. Analytical methodology .............................. 15 4.4.
  • Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS

    Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS

    Clinical, Forensic & Toxicology Article “The Big Pain”: Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS By Sharon Lupo As the use of prescription and nonprescription drugs grows, the need for fast, accurate, and comprehensive methods is also rapidly increasing. Historically, drug testing has focused on forensic applications such as cause of death determinations or the detection of drug use in specific populations (military, workplace, probation/parole, sports doping). However, modern drug testing has expanded well into the clinical arena with a growing list of target analytes and testing purposes. Clinicians often request the analysis of large panels of drugs and metabolites that can be used to ensure compliance with prescribed pain medication regimens and to detect abuse or diversion of medications. With prescription drug abuse reaching epidemic levels [1], demand is growing for analytical methods that can ensure accurate results for comprehensive drug lists with reasonable analysis times. LC-MS/MS is an excellent technique for this work because it offers greater sensitivity and specificity than immunoassay and—with a highly selective and retentive Raptor™ Biphenyl column—can provide definitive results for a wide range of compounds. Typically, forensic and pain management drug testing consists of an initial screening analysis, which is qualitative, quick, and requires only minimal sample preparation. Samples that test positive during screening are then subjected to a quantitative confirmatory analysis. Whereas screening assays may cover a broad list of compounds and are generally less sensitive and specific, confirmation testing provides fast, targeted analysis using chromatographic conditions that are optimized for specific panels.
  • 2015-02 Toxicology Rapid Testing Panel

    2015-02 Toxicology Rapid Testing Panel

    SOUTH CAROLINA LAW ENFORCEMENT DIVISION NIKKI R. HALEY MARK A. KEEL Governor Chief FORENSIC SERVICES LABORATORY CUSTOMER NOTICE 2015-02 REGARDING TOXICOLOGY RAPID TESTING PANEL August 12, 2015 This notice is to inform the Coroners of South Carolina of a new testing panel available through the SLED Toxicology Department. On Monday, August 17th, the Toxicology Department will begin offering both a Rapid Testing Panel in addition to the already available Expanded Testing Panel. This Rapid Testing Panel is to be utilized in cases where the Expanded Testing Panel is not warranted, specifically where a cause of death has already been established. The Rapid Testing Panel will consist of volatiles analysis, to include, ethanol, acetone, isopropanol and methanol, drug screens, and drug confirmation/quantitation of positive screens. The cases assigned to the Rapid Testing Panel will have an expedited turnaround time. Targeted turn around times will be two weeks for negative cases and six weeks or less for positive cases. While every effort will be made to adhere to these time frames, additional time may be required on occasion due to the nature of postmortem samples. Submitters will be notified if there is a problem with a particular sample. Please see attachment regarding specifically which substances are covered by the Rapid Testing Panel and the Expanded Testing Panel. As always, a detailed case history and list of drugs suspected is appreciated. Rapid Panel and Expanded Panel will be choices available in iLAB. Please contact Lt. Dustin Smith (803-896-7385) with additional questions. ALI-359-T An Accredited Law Enforcement Agency P.O.
  • Properties and Units in Clinical Pharmacology and Toxicology

    Properties and Units in Clinical Pharmacology and Toxicology

    Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible.
  • Big Pain Assays Aren't a Big Pain with the Raptor Biphenyl LC Column

    Big Pain Assays Aren't a Big Pain with the Raptor Biphenyl LC Column

    Featured Application: 231 Pain Management and Drugs of Abuse Compounds in under 10 Minutes by LC-MS/MS Big Pain Assays Aren’t a Big Pain with the Raptor Biphenyl LC Column • 231 compounds, 40+ isobars, 10 drug classes, 22 ESI- compounds in 10 minutes with 1 column. • A Raptor SPP LC column with time-tested Restek Biphenyl selectivity is the most versatile, multiclass-capable LC column available. • Achieve excellent separation of critical isobars with no tailing peaks. • Run fast and reliable high-throughput LC-MS/MS analyses with increased sensitivity using simple mobile phases. The use of pain management drugs is steadily increasing. As a result, hospital and reference labs are seeing an increase in patient samples that must be screened for a wide variety of pain management drugs to prevent drug abuse and to ensure patient safety and adherence to their medication regimen. Thera- peutic drug monitoring can be challenging due to the low cutoff levels, potential matrix interferences, and isobaric drug compounds. To address these chal- lenges, many drug testing facilities are turning to liquid chromatography coupled with mass spectrometry (LC-MS/MS) for its increased speed, sensitivity, and specificity. As shown in the analysis below, Restek’s Raptor Biphenyl column is ideal for developing successful LC-MS/MS pain medication screening methodologies. With its exceptionally high retention and unique selectivity, 231 multiclass drug compounds and metabolites—including over 40 isobars—can be analyzed in just 10 minutes. In addition, separate panels have been optimized on the Raptor Biphenyl column specifically for opioids, antianxiety drugs, barbiturates, NSAIDs and analgesics, antidepressants, antiepileptics, antipsychotics, hallucinogens, and stimulants for use during confirmation and quantitative analyses.
  • Pjp3'2001.Vp:Corelventura

    Pjp3'2001.Vp:Corelventura

    Copyright © 2001 by Institute of Pharmacology Polish Journal of Pharmacology Polish Academy of Sciences Pol. J. Pharmacol., 2001, 53, 253261 ISSN 1230-6002 INFLUENCE OF DOXEPIN USED IN PREEMPTIVE ANALGESIA ON THE NOCICEPTION IN THE PERIOPERATIVE PERIOD. EXPERIMENTAL AND CLINICAL STUDY Jerzy Wordliczek, Marcin Banach, Magdalena Dorazil, Barbara Przew³ocka*,# Department of Anaesthesiology and Intensive Care, 1st Chair of General Surgery of Collegium Medicum, Jagiellonian University, Kopernika 17, PL 31-501 Kraków, Poland, *Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smêtna 12, PL 31-343 Kraków, Poland Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study. J. WORDLI- CZEK, M. BANACH, M. DORAZIL, B. PRZEW£OCKA. Pol. J. Pharma- col., 2001, 53, 253–261. The aim of the present research was to assess in experimental and clini- cal study the influence of doxepin administered intraperitoneally (ip) as pre- emptive analgesia on the nociception in the perioperative period. The pain thresholds for mechanical stimuli were measured in rats. The objective of clinical investigation was to assess the influence of preemptive administra- tion of doxepin on postoperative pain intensity, analgesic requirement in the early postoperative period as well as an assessment of the quality of postope- rative analgesia by the patient. Doxepin injected ip (3–30 mg/kg) dose-dependently increased the pain threshold for mechanical stimuli measured in paw pressure test in rats. Do- xepin injected 30 min before formalin significantly increased the nociceptive threshold in the paw pressure test. In contrast, doxepin injected 240 min before formalin or 10 min after formalin did not change the nociceptive threshold.
  • A Textbook of Clinical Pharmacology and Therapeutics This Page Intentionally Left Blank a Textbook of Clinical Pharmacology and Therapeutics

    A Textbook of Clinical Pharmacology and Therapeutics This Page Intentionally Left Blank a Textbook of Clinical Pharmacology and Therapeutics

    A Textbook of Clinical Pharmacology and Therapeutics This page intentionally left blank A Textbook of Clinical Pharmacology and Therapeutics FIFTH EDITION JAMES M RITTER MA DPHIL FRCP FMedSci FBPHARMACOLS Professor of Clinical Pharmacology at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK LIONEL D LEWIS MA MB BCH MD FRCP Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School and the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA TIMOTHY GK MANT BSC FFPM FRCP Senior Medical Advisor, Quintiles, Guy's Drug Research Unit, and Visiting Professor at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK ALBERT FERRO PHD FRCP FBPHARMACOLS Reader in Clinical Pharmacology and Honorary Consultant Physician at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK PART OF HACHETTE LIVRE UK First published in Great Britain in 1981 Second edition 1986 Third edition 1995 Fourth edition 1999 This fifth edition published in Great Britain in 2008 by Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK, 338 Euston Road, London NW1 3BH http://www.hoddereducation.com ©2008 James M Ritter, Lionel D Lewis, Timothy GK Mant and Albert Ferro All rights reserved. Apart from any use permitted under UK copyright law, this publication may only be reproduced, stored or transmitted, in any form, or by any means with prior permission in writing of the publishers or in the case of reprographic production in accordance with the terms of licences issued by the Copyright Licensing Agency.
  • LZI Buprenorphine Enzyme Immunoassay for in Vitro Diagnostic Use Only 8ºC 0270 (100/37.5 Ml R1/R2 Kit) 0271 (1000/375 Ml R1/R2 Kit) 2ºC

    LZI Buprenorphine Enzyme Immunoassay for in Vitro Diagnostic Use Only 8ºC 0270 (100/37.5 Ml R1/R2 Kit) 0271 (1000/375 Ml R1/R2 Kit) 2ºC

    LZI Buprenorphine Enzyme Immunoassay For In Vitro Diagnostic Use Only 8ºC 0270 (100/37.5 mL R1/R2 Kit) 0271 (1000/375 mL R1/R2 Kit) 2ºC Lin-Zhi International, Inc. Intended Use Calibrators and Controls* The Lin-Zhi International (LZI) Buprenorphine Enzyme Immunoassay is *Calibrators and controls are sold separately and contain negative human intended for the qualitative and semi-quantitative determination of urine with sodium azide as a preservative. norbuprenorphine (a buprenorphine metabolite) in human urine at a cutoff value NORBUPRENORPHINE Calibrators/Controls REF of 5 ng/mL and 10 ng/mL. The assay is designed for prescription use with a Negative Calibrator 0001 number of automated clinical chemistry analyzers. Control: Contains 3 ng/mL norbuprenorphine 0272 The assay provides only a preliminary analytical result. A more specific Cutoff/Calibrator: Contains 5 ng/mL norbuprenorphine 0273 alternative analytical chemistry method must be used in order to obtain a Control: Contains 7 ng/mL norbuprenorphine 0274 confirmed analytical result. Gas or Liquid Chromatography/Mass Cutoff/Calibrator: Contains 10 ng/mL norbuprenorphine 0275 Control: Contains 13 ng/mL norbuprenorphine 0276 Spectrometry (GC/MS or LC/MS) are the preferred confirmatory methods Calibrator: Contains 20 ng/mL norbuprenorphine 0277 (1, 2). Clinical consideration and professional judgment should be exercised Calibrator: Contains 40 ng/mL norbuprenorphine 0278 with any drug of abuse test result, particularly when the preliminary test Calibrator: Contains 75 ng/mL norbuprenorphine 0279 result is positive. Precautions and Warning Summary and Explanation of Test • This test is for in vitro diagnostic use only. Harmful if swallowed. Buprenorphine is a semi-synthetic opioid derived from thebaine, an alkaloid of • Reagents used in the assay contain sodium azide as a preservative, which the poppy plant, Papaver somniferum.
  • US EPA, Pesticide Product Label, A335.06,09/21/2020

    US EPA, Pesticide Product Label, A335.06,09/21/2020

    [Note to reviewer: [Text] in brackets denotes optional or explanatory language [Note to reviewer: {Text} in braces denotes where in the final label text will appear {BOOKLET FRONT PANEL LANGUAGE} S-METOLACHLOR GROUP 15 HERBICIDE METRIBUZIN GROUP 5 HERBICIDE FOMESAFEN GROUP 14 HERBICIDE A335.06[™] [Alternate Brand Name: Statler] [Herbicide for preemergent control of certain grasses and broadleaf weeds in Soybeans] ACTIVE INGREDIENTS: (% by weight) S-Metolachlor*………………………………………….……………………………………………………………………………..…………………… 36.29% Metribuzin**………………………………………….……………………………………………………………………………..………………………. 8.05% Fomesafen***………………………………………….……………………………………………………………………………..……………………... 7.16% OTHER INGREDIENTS: ……………………………………………………..…………………………………………………………………………….. 48.5% TOTAL …………………………………………………………………………………………………………….……………………………………………. 100.0% *contains 3.39 Ib of S-metolachlor per gallon **contains 0.75 Ib of metribuzin per gallon ***contains 0.67 Ib of fomesafen acid per gallon KEEP OUT OF REACH OF CHILDREN CAUTION Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you do not understand the label, find someone to explain it to you in detail.) See [below] [inside label booklet] for [additional] [First Aid,] [Precautionary Statements] and [Directions for Use]. EPA Reg. No.: 91234-201 EPA Est. No.: Net Weight: Manufactured for: Atticus, LLC 5000 CentreGreen Way, Suite 100 Cary, NC 27513 1 {LANGUAGE INSIDE BOOKLET} FIRST AID If on skin or Take off contaminated clothing. clothing: Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice. If swallowed: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor.
  • A Generic LC-MS Method for the Analysis of Multiple of Drug of Abuse Classes with the Thermo Scientific Exactive TM System

    A Generic LC-MS Method for the Analysis of Multiple of Drug of Abuse Classes with the Thermo Scientific Exactive TM System

    A Generic LC-MS Method for the Analysis of Multiple of Drug of Abuse Classes with the Thermo Scientific Exactive TM System Kent Johnson Fortes lab, Wilsonville Oregon Forensic Toxicology Use Only List of drug of abuse candidates for LC-MS analysis Sample matrix: urine and blood Benzodiazepines Opiates Other drugs group 1 Other drugs group 2 7-Aminonitrazepam Morphine Ketamine Methylphenidate 7-Aminoclonazepam Hydromorphone Norketamine Ritalinic Acid 7-Aminoflunitrazepam Oxymorphone Butorphanol Dextromethorphan 2-Hydroxy-ethyl-flurazepam Codeine Fentanyl Dextrophan Desalkylflurazepam Dihydrocodeine Norfentanyl Propoxyphene Diazepam Hydrocodone Nalbuphine Norpropoxyphene Hydroxy-alprazolam Oxycodone Alfentanil 6-MAM Hydroxy-triazolam Meperidine Sulfentanil Nordiazepam Normeperidine Zolpidem Lorazepam Trazodone Oxazepam Venlafaxine Temazepam Zopiclone Forensic Toxicology Use Only 2 Methods Employed Prior to LC-MS • Benzodiazepines GC-MS • Opiates GC-MS • Other drugs of abuse group 1 ELISA • Other drugs of abuse group 2 not analyzed before Forensic Toxicology Use Only 3 Why switch to LC-MS method? Benefits of replacing GC-MS • Faster less need for chromatographic separation • Less sample prep no derivatization • No thermal instability benzodiazepines analysis • No volatility limitations Benefits of replacing immunoassay • Lower consumables cost • More specific More cost efficient and analytically more universal Forensic Toxicology Use Only 4 Goal • Develop fast, easy to use, generic LC-MS method to analyze multiple classes of drugs
  • Fatal Toxicity of Antidepressant Drugs in Overdose

    Fatal Toxicity of Antidepressant Drugs in Overdose

    BRITISH MEDICAL JOURNAL VOLUME 295 24 OCTOBER 1987 1021 Br Med J (Clin Res Ed): first published as 10.1136/bmj.295.6605.1021 on 24 October 1987. Downloaded from PAPERS AND SHORT REPORTS Fatal toxicity of antidepressant drugs in overdose SIMON CASSIDY, JOHN HENRY Abstract dangerous in overdose, thus meriting investigation of their toxic properties and closer consideration of the circumstances in which A fatal toxicity index (deaths per million National Health Service they are prescribed. Recommendations may thus be made that prescriptions) was calculated for antidepressant drugs on sale might reduce the number offatalities. during the years 1975-84 in England, Wales, and Scotland. The We used national mortality statistics and prescription data tricyclic drugs introduced before 1970 had a higher index than the to compile fatal toxicity indices for the currently available anti- mean for all the drugs studied (p<0-001). In this group the depressant drugs to assess the comparative safety of the different toxicity ofamitriptyline, dibenzepin, desipramine, and dothiepin antidepressant drugs from an epidemiological standpoint. Owing to was significantly higher, while that ofclomipramine, imipramine, the nature of the disease these drugs are particularly likely to be iprindole, protriptyline, and trimipramine was lower. The mono- taken in overdose and often cause death. amine oxidase inhibitors had intermediate toxicity, and the antidepressants introduced since 1973, considered as a group, had significantly lower toxicity than the mean (p<0-001). Ofthese newer drugs, maprotiline had a fatal toxicity index similar to that Sources ofinformation and methods of the older tricyclic antidepressants, while the other newly The statistical sources used list drugs under their generic and proprietary http://www.bmj.com/ introduced drugs had lower toxicity indices, with those for names.
  • Aust Pres 27-2 for Pdfs.Indd

    Aust Pres 27-2 for Pdfs.Indd

    Does pethidine still have a place in the management of labour pain? Richard W. Watts, Rural General Practitioner, Port Lincoln, South Australia Summary between the median or mean visual analogue pain scores in the pethidine and placebo groups. Pethidine significantly increased Pethidine can provide short-term relief of acute the sedation scores, dizziness, nausea and vomiting.4 pain, but it is not effective for everyone. During labour, intramuscular or intravenous pethidine Comparison with other analgesics sedates women, but may not give them adequate In a randomised controlled trial involving 20 patients in labour, analgesia. Pethidine and its active metabolite, pethidine (up to 1.5 mg/kg) and morphine (up to 0.15 mg/kg) given intravenously produced no significant change in pain norpethidine, can have adverse effects on the scores over time with three doses. Following treatment with neonate as well as the mother, especially if opioids 15 of the patients requested an epidural. Nausea was repeated doses are given during labour. There more common with pethidine (6/10) than with morphine (1/10). is little evidence to show that other drugs have Patients receiving pethidine were calmer and more euphoric, greater efficacy than pethidine, so epidural but both drugs caused similar significant sedation (mean analgesia may be a more effective option. sedation scores 8/10 after three doses). The patients were therefore all significantly sedated and fell asleep during labour, Key words: analgesia, breastfeeding, epidural. but were awakened by pain during contractions. The researchers (Aust Prescr 2004;27:34–5) concluded that labour pain was not sensitive to systemically administered pethidine or morphine and that it was unethical to Introduction treat requests for pain relief by giving sedation.5 Many women prefer to experience birth actively and as naturally Pethidine has also been compared with intravenous fentanyl6, as possible.