Poster Session Iituesday, December 09, 2014
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
NMDA Receptor Dynamics Dictate Neuronal Plasticity and Function
NMDA Receptor Dynamics Dictate Neuronal Plasticity and Function Tommy Weiss Sadan, Ph.D. and Melanie R. Grably, Ph.D. N-Methyl-D-Aspartate Receptor (NMDAR) are ubiquitously expressed along the central nervous system and are instrumental to various physiological processes such as synaptic plasticity and learning. Nevertheless, several mental disabilities including schizophrenia and Alzheimer’s disease are all related to NMDAR dysfunction. Here, we review many aspects of NMDAR function and regulation and describe their involvement in pathophysiological states using Alomone Labs products. Right: Cell surface detection of GluN2B in rat hippocampal neurons. Introduction Mechanism of Action Glutamate is a key neuro-transmitter in the central nervous system and NMDAR activation depends on sequential conformational changes to acts on a variety of cell surface receptors, collectively termed ionotropic relieve the magnesium blockade which is achieved by rapid membrane glutamate receptors (iGluRs)15. The N-Methyl-D-Aspartate receptors (NMDAR) depolarization and binding of both glycine and glutamate ligands6, 21. This in are members of the iGluR superfamily and are pivotal to many physiological turn removes the inhibitory electrostatic forces of magnesium and enables processes such as the formation of long term memory, synaptic plasticity calcium influx and transmission of long lasting signals (i.e. long-term and many other cognitive functions. Therefore, it is not surprising that potentiation), a key mechanism to learning and memory formation10. -
Abstract Book – Oral Sessions
Sunday, June 21, 2015 12:00 p.m. - 1:15 p.m. Latin American Psychopharmacology Update: INNOVATIVE TREATMENTS IN PSYCHIATRY INNOVATIVE TREATMENTS IN PSYCHIATRY Flavio Kapczinski, The University of Texas Health Science Center at Houston Overall Abstract In this panel, we will propose innovative treatments in psychiatry and recent literature findings will be summarized. The effective pharmacological treatment of psychiatric diseases and development of new therapeutic entities has been a long-standing challenge. Despite the complexity and heterogeneity of psychiatric disorders, basic and clinical research studies and technological advancements in genomics, biomarkers, and imaging have begun to elucidate the pathophysiology of etiological complexity of psychiatric diseases and to identify efficacious new agents (Tcheremissine et al. 2014). Many psychiatric illnesses are associated with neuronal atrophy, characterized by loss of synaptic connections, increase of inflammatory markers like TNF-α and DAMPS (damage-associate molecular patterns,- cell free (ccf) DNA, heat shock proteins HSP70, HSP90, and HSP60, and cytochrome C), decrease of neurotrophic factors, increase of oxidative stress, mitochondrial dysfunction and apoptosis (Fries et al., 2012; Pfaffenseller et al., 2014). Also, neurocognitive impairment and poor psychosocial functioning has been related to a psychiatric disease. Therefore, trying to discover new therapeutic targets that act in these pathways can help to develop new treatment or improve the treatment of these serious diseases. -
Enzymatic Encoding Methods for Efficient Synthesis Of
(19) TZZ__T (11) EP 1 957 644 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C12N 15/10 (2006.01) C12Q 1/68 (2006.01) 01.12.2010 Bulletin 2010/48 C40B 40/06 (2006.01) C40B 50/06 (2006.01) (21) Application number: 06818144.5 (86) International application number: PCT/DK2006/000685 (22) Date of filing: 01.12.2006 (87) International publication number: WO 2007/062664 (07.06.2007 Gazette 2007/23) (54) ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES ENZYMVERMITTELNDE KODIERUNGSMETHODEN FÜR EINE EFFIZIENTE SYNTHESE VON GROSSEN BIBLIOTHEKEN PROCEDES DE CODAGE ENZYMATIQUE DESTINES A LA SYNTHESE EFFICACE DE BIBLIOTHEQUES IMPORTANTES (84) Designated Contracting States: • GOLDBECH, Anne AT BE BG CH CY CZ DE DK EE ES FI FR GB GR DK-2200 Copenhagen N (DK) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI • DE LEON, Daen SK TR DK-2300 Copenhagen S (DK) Designated Extension States: • KALDOR, Ditte Kievsmose AL BA HR MK RS DK-2880 Bagsvaerd (DK) • SLØK, Frank Abilgaard (30) Priority: 01.12.2005 DK 200501704 DK-3450 Allerød (DK) 02.12.2005 US 741490 P • HUSEMOEN, Birgitte Nystrup DK-2500 Valby (DK) (43) Date of publication of application: • DOLBERG, Johannes 20.08.2008 Bulletin 2008/34 DK-1674 Copenhagen V (DK) • JENSEN, Kim Birkebæk (73) Proprietor: Nuevolution A/S DK-2610 Rødovre (DK) 2100 Copenhagen 0 (DK) • PETERSEN, Lene DK-2100 Copenhagen Ø (DK) (72) Inventors: • NØRREGAARD-MADSEN, Mads • FRANCH, Thomas DK-3460 Birkerød (DK) DK-3070 Snekkersten (DK) • GODSKESEN, -
(12) United States Patent (10) Patent No.: US 8,748,131 B2 Ford (45) Date of Patent: Jun
USOO8748131B2 (12) United States Patent (10) Patent No.: US 8,748,131 B2 Ford (45) Date of Patent: Jun. 10, 2014 (54) CHIMERIC NEUREGULINS AND METHOD in Neuregulin-1/ErbB Signaling. The Journal of Biological Chemis OF MAKING AND USE THEREOF try vol. 285, No. 41, pp. 31388-31398, Oct. 8, 2010.* Veronese et al., PEGylation. Successful approach to drug delivery. (71) Applicant: Morehouse School of Medicine, Drug Discovery Today vol. 10, No. 21 Nov. 2005, 1451-1458.* Atlanta, GA (US) Carraway et al., Neuregulin-2, a new ligand ErbB3/ErbB4-receptor tyrosine kinases. Nature, vol. 387, May 29, 1997, 512-516.* (72) Inventor: Byron D. Ford, Atlanta, GA (US) Higashiyamaet al., ANovel Brain-Derived Member of the Epidermal Growth Factor Family That Interacts with ErbB3 and ErbB4. J. (73) Assignee: Morehouse School of Medicine, Biochem. 122,675-680 (1997).* Atlanta, GA (US) Fischbach et al., “ARIA: A Neuromuscular Junction Neuregulin.” Annual Review of Neuroscience, 1997, pp. 429–458, vol. 20. (*) Notice: Subject to any disclaimer, the term of this Buonanno et al., “Neuregulin and ErbB receptor signaling pathways patent is extended or adjusted under 35 in the nervous system.” Current Opinion in Neurobiology, 2001, pp. U.S.C. 154(b) by 0 days. 287-296, vol. 11. Burden et al., “Neuregulins and Their Receptors: A Versatile Signal Appl. No.: 13/627,555 ing Module in Organogenesis and Oncogenesis. Neuron, 1997, pp. (21) 847-855, vol. 18. Fu et al., “Cdk5 is involved in neuregulin-induced AChR expression (22) Filed: Sep. 26, 2012 at the neuromuscular junction.” Nature Neuroscience, Apr. -
JPET #82990 Identification of Subunit-Specific and Antagonist
JPET Fast Forward. Published on March 2, 2005 as DOI: 10.1124/jpet.104.082990 JPET ThisFast article Forward. has not been Published copyedited onand formatted.March 2, The 2005 final versionas DOI:10.1124/jpet.104.082990 may differ from this version. JPET #82990 Identification of subunit-specific and antagonist-specific amino acid residues in the NMDA receptor glutamate binding pocket Downloaded from Leo Kinarsky1, Bihua Feng1, Donald A. Skifter, Richard M. Morley, Simon Sherman, jpet.aspetjournals.org David E. Jane, and Daniel Monaghan. 1The Eppley Research Institute (L.K., S.S.) and the Department of Pharmacology (B.F., D.A.S., D.T.M.) University of Nebraska Medical Center; and Department of Pharmacology, University of Bristol, Bristol, U.K. (R.M.M., at ASPET Journals on September 26, 2021 D.E.J.). 1 Copyright 2005 by the American Society for Pharmacology and Experimental Therapeutics. JPET Fast Forward. Published on March 2, 2005 as DOI: 10.1124/jpet.104.082990 This article has not been copyedited and formatted. The final version may differ from this version. JPET #82990 Running title: NR2 glutamate binding site models Correspondence: Downloaded from Daniel T. Monaghan, Ph.D. Department of Pharmacology 985800 Nebraska Medical Center jpet.aspetjournals.org Omaha, NE 68198-5800 402-559-7196, FAX: 402-559-7495, e-mail: [email protected] at ASPET Journals on September 26, 2021 Pages: 19 Tables: 0 Figures: 6 References: 40 Number of words Abstract: 243 Introduction: 607 Discussion: 1369 2 JPET Fast Forward. Published on March 2, 2005 as DOI: 10.1124/jpet.104.082990 This article has not been copyedited and formatted. -
Gephyrin: a Scaffold That Builds a Phase at the Inhibitory Postsynapses
www.nature.com/cr www.cell-research.com RESEARCH HIGHLIGHT OPEN Gephyrin: a scaffold that builds a phase at the inhibitory postsynapses Christian Hoffmann 1 and Dragomir Milovanovic 1 Cell Research (2021) 31:245–246; https://doi.org/10.1038/s41422-020-00440-2 The scaffolding protein gephyrin is a core component of many GPHN-E. Besides GlyR-β, TM3–4 loops of GABAAR α3-subunit also inhibitory synapses. Bai and colleagues now show that phase phase separates with GPHN-E suggesting liquid condensation to separation of gephyrin with the subunits of both glycine and be a general feature of inhibitory synapses (Fig. 1). The phase GABA receptors underlies the formation of postsynaptic separation occurs at the equimolar ratio of receptors and scaffold sheets at the inhibitory synapses. proteins, a range similar to their physiological concentrations.8 To assure precise processing of information, contacts between There are several implications of this study. First, the observa- neurons require the alignment of the release sites, presynaptic tion that different regions of the same proteins (GlyR-β and GPHN- terminals, with the ionotropic transmitter receptors at the E) are important for phase separation or direct binding, suggests postsynaptic plasma membrane. Downstream of these receptors, that these two processes could be regulated separately. The scaffold molecules, kinases and cytoskeleton components all positively charged region of GlyR-β (a.a. 354–383) and negatively orchestrate the signaling cascade induced by the neurotransmitter charged surface at the subdomain II of GPHN-E are essential for fl 1234567890();,: binding and ion in ux. Each neuron in the mammalian central condensate formation, despite hydrophobic interactions being nervous system relies on both the excitatory and inhibitory inputs. -
And HPV18-Infected Early Stage Cervical Cancers and Normal
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Virology 331 (2005) 269–291 www.elsevier.com/locate/yviro Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy Alessandro D. Santina,*, Fenghuang Zhanb, Eliana Bignottia, Eric R. Siegelc, Stefania Cane´ a, Stefania Bellonea, Michela Palmieria, Simone Anfossia, Maria Thomasd, Alexander Burnetta, Helen H. Kaye, Juan J. Romana, Timothy J. O’Briena, Erming Tianb, Martin J. Cannonf, John Shaughnessy Jr.b, Sergio Pecorellig aDivision of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA bMyeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA cDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA dDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA eDepartment of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA fDepartment of Microbiology and Immunology, University of Arkansas, Little Rock, AR 72205, USA gDivision of Gynecologic Oncology, University of Brescia, Brescia, Italy Received 2 July 2004; returned to author for revision 18 August 2004; accepted 9 September 2004 Available online 21 November 2004 Abstract With the goal of identifying genes with a differential pattern of expression between invasive cervical carcinomas (CVX) and normal cervical keratinocytes (NCK), we used oligonucleotide microarrays to interrogate the expression of 14,500 known genes in 11 primary HPV16 and HPV18-infected stage IB–IIA cervical cancers and four primary normal cervical keratinocyte cultures. -
Supplementary Table S4. FGA Co-Expressed Gene List in LUAD
Supplementary Table S4. FGA co-expressed gene list in LUAD tumors Symbol R Locus Description FGG 0.919 4q28 fibrinogen gamma chain FGL1 0.635 8p22 fibrinogen-like 1 SLC7A2 0.536 8p22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 DUSP4 0.521 8p12-p11 dual specificity phosphatase 4 HAL 0.51 12q22-q24.1histidine ammonia-lyase PDE4D 0.499 5q12 phosphodiesterase 4D, cAMP-specific FURIN 0.497 15q26.1 furin (paired basic amino acid cleaving enzyme) CPS1 0.49 2q35 carbamoyl-phosphate synthase 1, mitochondrial TESC 0.478 12q24.22 tescalcin INHA 0.465 2q35 inhibin, alpha S100P 0.461 4p16 S100 calcium binding protein P VPS37A 0.447 8p22 vacuolar protein sorting 37 homolog A (S. cerevisiae) SLC16A14 0.447 2q36.3 solute carrier family 16, member 14 PPARGC1A 0.443 4p15.1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha SIK1 0.435 21q22.3 salt-inducible kinase 1 IRS2 0.434 13q34 insulin receptor substrate 2 RND1 0.433 12q12 Rho family GTPase 1 HGD 0.433 3q13.33 homogentisate 1,2-dioxygenase PTP4A1 0.432 6q12 protein tyrosine phosphatase type IVA, member 1 C8orf4 0.428 8p11.2 chromosome 8 open reading frame 4 DDC 0.427 7p12.2 dopa decarboxylase (aromatic L-amino acid decarboxylase) TACC2 0.427 10q26 transforming, acidic coiled-coil containing protein 2 MUC13 0.422 3q21.2 mucin 13, cell surface associated C5 0.412 9q33-q34 complement component 5 NR4A2 0.412 2q22-q23 nuclear receptor subfamily 4, group A, member 2 EYS 0.411 6q12 eyes shut homolog (Drosophila) GPX2 0.406 14q24.1 glutathione peroxidase -
Germanic Surname Lexikon
Germanic Surname Lexikon Most Popular German Last Names with English Meanings German for Beginners: Contents - Free online German course Introduction German Vocabulary: English-German Glossaries For each Germanic surname in this databank we have provided the English Free Online Translation To or From German meaning, which may or may not be a surname in English. This is not a list of German for Beginners: equivalent names, but rather a sampling of English translations of German names. Das Abc German for Beginners: In many cases, there may be several possible origins or translations for a Lektion 1 surname. The translation shown for a surname may not be the only possibility. Some names are derived from Old German and may have a different meaning from What's Hot that in modern German. Name research is not always an exact science. German Word of the Day - 25. August German Glossary of Abbreviations: OHG (Old High German) Words to Avoid - T German Words to Avoid - Glossary Warning German Glossary of Germanic Last Names (A-K) Words to Avoid - With English Meanings Feindbilder German Words to Avoid - Nachname Last Name English Meaning A Special Glossary Close Ad A Dictionary of German Aachen/Aix-la-Chapelle Names Aachen/Achen (German city) Hans Bahlow, Edda ... Best Price $16.95 Abend/Abendroth evening/dusk or Buy New $19.90 Abt abbott Privacy Information Ackerman(n) farmer Adler eagle Amsel blackbird B Finding Your German Ancestors Bach brook Kevan M Hansen Best Price $4.40 Bachmeier farmer by the brook or Buy New $9.13 Bader/Baader bath, spa keeper Privacy Information Baecker/Becker baker Baer/Bar bear Barth beard Bauer farmer, peasant In Search of Your German Roots. -
(12) Patent Application Publication (10) Pub. No.: US 2006/0178307 A1 Bartlett Et Al
US 2006O1783 07A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0178307 A1 Bartlett et al. (43) Pub. Date: Aug. 10, 2006 (54) MODULATION OF NMDA RECEPTOR Publication Classification CURRENTS VIA OREXN RECEPTOR AND/OR CRF RECEPTOR (51) Int. Cl. A6II 38/22 (2006.01) (75) Inventors: Selena Bartlett, Berkeley, CA (US); A6II 3L/495 (2006.01) Antonello Bonci, San Francisco, CA A61K 31/4745 (2006.01) (US); Stephanie Borgland, San A61K 31/4706 (2006.01) Francisco, CA (US); Howard Fields, A6II 3/17 (2006.01) Berkeley, CA (US); Sharif Taha, (52) U.S. Cl. ...................... 514/12: 514/255.01: 514/300; Berkeley, CA (US) 514/313; 514/585; 514/595 (57) ABSTRACT Correspondence Address: QUINE INTELLECTUAL PROPERTY LAW This invention pertains to the discoveries that orexin and/or GROUP, PC. CRF increase NMDAR (N-methyl-D-aspartate receptor)- PO BOX 458 mediated currents at excitatory synapses onto a Subset of dopamine cells in the ventral tegmental area (VTA) in the ALAMEDA, CA 94501 (US) mammalian brain. The orexin effect can be blocked by an (73) Assignee: The Regents of the University of Cali orexin receptor type 1 (OXR1). The CRF effect can be blocked by a CRF receptor 2 (CRF-R2) antagonist or by an fornia inhibitor of the CRF-binding protein (CRF-BP). Methods (21) Appl. No.: 11/343,259 are provided that exploit these discoveries to modulate NMDAR-mediated currents in vivo and in vitro and to (22) Filed: Jan. 25, 2006 screen for modulators (upregulators or downregulators) of NMDA-mediated currents. In vivo methods include the use Related U.S. -
Brain Metabolic Profile After Intranasal Vs. Intraperitoneal Clomipramine
International Journal of Molecular Sciences Article Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression Olga Abramova 1,2, Yana Zorkina 1,2,* , Timur Syunyakov 2,3 , Eugene Zubkov 1, Valeria Ushakova 1,2, Artemiy Silantyev 1, Kristina Soloveva 2, Olga Gurina 1, Alexander Majouga 4, Anna Morozova 1,2 and Vladimir Chekhonin 1,5 1 V. Serbsky National Medical Research Centre of Psychiatry and Narcology, 119034 Moscow, Russia; [email protected] (O.A.); [email protected] (E.Z.); [email protected] (V.U.); [email protected] (A.S.); [email protected] (O.G.); [email protected] (A.M.); [email protected] (V.C.) 2 Mental-Health Clinic No. 1 Named after N.A. Alekseev, 117152 Moscow, Russia; [email protected] (T.S.); [email protected] (K.S.) 3 Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, 125315 Moscow, Russia 4 Drug Delivery Systems Laboratory, D. Mendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, 125047 Moscow, Russia; [email protected] 5 Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia * Correspondence: [email protected]; Tel.: +7-916-588-4851 Citation: Abramova, O.; Zorkina, Y.; Abstract: Background: Molecular mechanisms of depression remain unclear. The brain metabolome Syunyakov, T.; Zubkov, E.; Ushakova, after antidepressant therapy is poorly understood and had not been performed for different routes V.; Silantyev, A.; Soloveva, K.; Gurina, of drug administration before the present study. Rats were exposed to chronic ultrasound stress O.; Majouga, A.; Morozova, A.; et al. and treated with intranasal and intraperitoneal clomipramine. -
Generate Metabolic Map Poster
Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000702945Cyc: Clostridium sp. KNHs205 Cellular Overview Connections between pathways are omitted for legibility.